Motor Neuron Disease: Amyotrophic Lateral Sclerosis

Name	AC	CK
Vitamin E	6	43
Coenzyme Q10	4	23
Vitamin B-12	3	21
Vitamin B12: methylcobalamin	3	21
Progesterone	4	16
Testosterone	3	14
Antioxidant formulas	3	13
Vitamin D	2	12
Cannabinoids	7	11
Estradiol (E(2))	7	11
Glutathione	2	11
B-complex	1	10
Capsaicin	1	10
Copper	1	10
Fruit: All	1	10
Polyunsaturated Fatty Acids (PUFAs)	1	10
Selenium	1	10
Superoxide dismutase	1	10
Vegetables: All	1	10
Whey	1	10
Zinc	1	10
Cannabis	5	9
Glycoaminoglycans	4	8
Insulin-like Growth Factor (IGF-1)	4	7
Curcumin	5	6
Catechin	1	5
EGCG (Epigallocatechin gallate)	3	5
Resveratrol	4	5
Melatonin	4	4
Polyphenols	4	4
Alpha-Lipoic Acid	2	3
Ginkgo biloba	2	3
Palmitoylethanolamide	1	3
Stilbenes	2	3
5-HTP (5-Hydroxytryptophan)	1	2
Amino Acids: Branched Chain	1	2
Arginine	1	2
Astragalus	1	2
Bee Venom	1	2
Caprylic Acid	1	2
Coconut Oil	1	2
EPA (Eicosapentaenoic Acid)	1	2
Fisetin	1	2
Flavonoids	2	2
Galactooligosaccharides	1	2
Genistein	1	2
Ginseng	1	2
Glycyrrhiza uralensis	1	2
Prebiotics	1	2
Pyruvate	1	2
Red Wine Extract	2	2
Rosemaric Acid	1	2
Rosemary	1	2
S-Adenosylmethionine (SAMe)	1	2
Scolopendra subspinipes mutilans	1	2
Wen Pi Tang	1	2
phytoestrogens	1	2
Ashwagandha	1	1
Astragaloside	1	1
Caffeic acid phenethyl ester	1	1
Carnitine	1	1
Carotenoids	1	1
Folic Acid	1	1
Herbal Therapies (Unspecified in Abstracts)	1	1
Hesperidin	1	1
Lemon	1	1
Olive	1	1
Wine	1	1
acetyl-11-keto-beta-boswellic acid	1	1

Name	AC	CK
Pesticides	4	31
Lead	4	25
Statin Drugs	2	20
Tobacco	2	20
Agricultural Chemicals	1	10
L-glutamic Acid	1	10
Monosodium Glutamate (MSG)	1	10
Nicotine	1	10
Persistent organic pollutants (POPs)	1	10
Lyme's Disease (Borrelia burgdorferi)	3	9
Aluminum	3	3
Mercury	2	3
Excitotoxins	1	1
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	1

Name	AC	CK
Exercise	4	16
Stem Cell Related Therapy	4	15
Acupuncture	1	10
Meditation	1	10
Spiritual/Religious Practice	1	10
Therapeutic Breathing	1	10
Electroacupuncture	1	2
Exercise: Running	1	2
Exercise: Swimming	1	2
Intermittent Hypoxia (low oxygen)	1	2
Dietary Modification: High-Fat/Low-Carbohydrate	1	1
Dietary Modification: Low Carbohydrate/Ketogenic	1	1
Dietary Modification: Mediterranean Diet	1	1

Name	AC	CK
Electromagnetic Field Harms	4	55
Electromagnetic Radiation	3	35
Vaccination: All	3	3

Adverse Pharmacological Actions : Neurotoxic

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Coenzyme Q10 levels as high as 3,000 mg a day are safe and well-tolerated in ALS patients. Dec 13, 2005

Click here to read the entire abstract

Pubmed Data : Neurology. 2005 Dec 13;65(11):1834-6. PMID: 16344537

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Epidemiol. 2011 Mar 15 ;173(6):595-602. Epub 2011 Feb 18. PMID: 21335424

Click here to read the entire abstract

Pubmed Data : Int J Radiat Biol. 2019 03 ;95(3):368-377. Epub 2019 Jan 4. PMID: 30513241

Article Published Date : Jan 01, 2019

Study Type : Human In Vitro

Additional Links

Diseases : Amyotrophic Lateral Sclerosis

Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation

Adverse Pharmacological Actions : Oxidant

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Fungal infection in neural tissue of patients with amyotrophic lateral sclerosis.Nov 30, 2017

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Pubmed Data : Neurobiol Dis. 2017 Dec ;108:249-260. Epub 2017 Sep 6. PMID: 28888971

Article Published Date : Nov 30, 2017

Study Type : Human In Vitro

Additional Links

Diseases : Amyotrophic Lateral Sclerosis, Fungus Diseases

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Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG.Sep 01, 2007

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Pubmed Data : Curr Alzheimer Res. 2007 Sep ;4(4):403-11. PMID: 17908043

Article Published Date : Sep 01, 2007

Study Type : Human In Vitro

Additional Links

Substances : Catechin

Diseases : Amyotrophic Lateral Sclerosis, Huntington Disease, Neurodegenerative Diseases, Parkinson's Disease

Pharmacological Actions : Antioxidants, Neuroprotective Agents, Regenerative

Additional Keywords : Nerve Regeneration

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Resveratrol's neural protective effects for the injured embryoid body and cerebral organoid.Jul 11, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Pharmacol Toxicol. 2022 Jul 12 ;23(1):47. Epub 2022 Jul 12. PMID: 35820950

Click here to read the entire abstract

Pubmed Data : CNS Neurol Disord Drug Targets. 2012 Nov 1 ;11(7):933-6. PMID: 22998138

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Pubmed Data : Eur J Pharmacol. 2006 Aug 7;542(1-3):100-5. Epub 2006 May 20. PMID: 16781706

Article Published Date : Aug 07, 2006

Study Type : Animal Study

Additional Links

Substances : Cannabinoids

Diseases : Amyotrophic Lateral Sclerosis

Pharmacological Actions : Neuroprotective Agents

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Anti-inflammatory effects of a novel herbal extract in the muscle and spinal cord of an Amyotrophic lateral sclerosis.Dec 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Neurosci. 2021 ;15:743705. Epub 2021 Nov 11. PMID: 34858128

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Pubmed Data : PLoS One. 2012 ;7(11):e49191. Epub 2012 Nov 7. PMID: 23145119

Article Published Date : Dec 31, 2011

Study Type : Animal Study

Additional Links

Substances : Caprylic Acid

Diseases : Amyotrophic Lateral Sclerosis

Pharmacological Actions : Superoxide Dismutase Up-regulation

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Co-administration of IGF-I and glycosaminoglycans greatly delays motor neuron disease in the mouse model.Apr 01, 2002

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Pubmed Data : J Neurochem. 2002 Apr;81(1):194-202. PMID: 12067233

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Pubmed Data : Neuromolecular Med. 2010 Mar ;12(1):86-97. Epub 2009 Sep 16. PMID: 19757209

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2013 ;8(2):e30243. Epub 2013 Feb 6. PMID: 23405058

Article Published Date : Dec 31, 2012

Study Type : Animal Study

Additional Links

Substances : Vitamin D

Diseases : Amyotrophic Lateral Sclerosis

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Female sex hormones such as estradiol and exercise have a possible neuroprotective role in female patients with ALS. Apr 01, 2009

Click here to read the entire abstract

Pubmed Data : Med Hypotheses. 2009 Apr;72(4):434-43. Epub 2009 Jan 19. PMID: 14561497

Article Published Date : Apr 01, 2009

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Pubmed Data : Neuroscience. 1999;93(2):565-72. PMID: 10465440

Article Published Date : Jan 01, 1999

Study Type : Animal Study

Additional Links

Substances : Glycoaminoglycans, Insulin-like Growth Factor (IGF-1)

Diseases : Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Peripheral Neuropathies

Pharmacological Actions : Apoptotic, Neuroprotective Agents

Additional Keywords : Drug Synergy

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Glycosaminoglycans co-administration enhance insulin-like growth factor-I neuroprotective and neuroregenerative activity in traumatic and genetic models of motor neuron disease.Jul 01, 2000

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Pubmed Data : Int J Dev Neurosci. 2000 Jul-Aug;18(4-5):339-46. PMID: 10817918

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Stem Cells Transl Med. 2013 Mar ;2(3):167-74. Epub 2013 Feb 14. PMID: 23413376

Article Published Date : Feb 28, 2013

Study Type : Animal Study

Additional Links

Diseases : Amyotrophic Lateral Sclerosis

Therapeutic Actions : Stem Cell Related Therapy

Pharmacological Actions : Superoxide Dismutase Up-regulation

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Non-invasive assessment of disease progression and neuroprotective effects of dietary coconut oil supplementation in the Amyotrophic lateral sclerosis.Sep 18, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Altern Complement Med. 2008 Nov;14(9):1159-64. PMID: 18973429

Article Published Date : Nov 01, 2008

Study Type : Commentary

Additional Links

Substances : Glutathione

Diseases : Amyotrophic Lateral Sclerosis

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A review of experimental research on herbal compounds in amyotrophic lateral sclerosis.Dec 31, 2013

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Pubmed Data : Phytother Res. 2014 Jan ;28(1):9-21. Epub 2013 Mar 21. PMID: 23519768

Article Published Date : Dec 31, 2013

Study Type : Review

Additional Links

Substances : Herbal Therapies (Unspecified in Abstracts)

Diseases : Amyotrophic Lateral Sclerosis

Additional Keywords : Plant Extracts

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Acetyl-11-keto-beta boswellic acid mediated neuroprotection in methyl mercury-induced experimental model of ALS.May 31, 2021

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Pubmed Data : Neurochem Res. 2021 Jun 1. Epub 2021 Jun 1. PMID: 34075522

Article Published Date : May 31, 2021

Curcumins promote monocytic gene expression related toβ-amyloid and superoxide dismutase clearance.Dec 31, 2011

Click here to read the entire abstract

Pubmed Data : Neurodegener Dis. 2012 ;10(1-4):274-6. Epub 2011 Dec 7. PMID: 22156608

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Respir Crit Care Med. 2013 Mar 1 ;187(5):535-42. Epub 2012 Dec 6. PMID: 23220913

Article Published Date : Feb 28, 2013

Study Type : Review

Additional Links

Diseases : Amyotrophic Lateral Sclerosis

Therapeutic Actions : Stem Cell Related Therapy

Pharmacological Actions : Superoxide Dismutase Up-regulation

[+]

It has been suggested that where it is legal to do so, marijuana should be considered in the pharmacological management of ALS.Jul 01, 2001

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Pubmed Data : Curr Pharm Des. 2022 ;28(10):806-828. PMID: 34781865

Click here to read the entire abstract

Pubmed Data : Curr Pharm Des. 2008;14(23):2306-16. PMID: 18781981

View the Evidence: 137 Abstracts with Motor Neuron Disease: Amyotrophic Lateral Sclerosis Research

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In this meta-analysis, there was an observed increased risk of amytrophic lateral sclerosis in workers occupationally exposed to extremely low frequency electromagnetic fields. Feb 01, 2018

There is an association between occupational exposure to power frequency electromagnetic fields and amyotrophic lateral sclerosis.Feb 01, 2003

A high intake of poluunsaturated fatty acids and vitamin E is associated with a 50-60% decreased risk of developing ALS. Apr 01, 2007

A higher intake of food rich in antioxidants such as fruit and vegetables confer protection against the development of ALS.Dec 19, 2003

A majority of patients with amyotrophic lateral sclerosis had signs of intestinal inflammation.Aug 31, 2017

An ALS-specific meditation programme is beneficial for the quality of life and psychological well-being of people with ALS.Mar 31, 2017

Autologous bone marrow-derived stem cell therapy is safe and feasible in patients of ALS.Aug 31, 2012

Capsaicin may improve swallowing impairment in patients with amyotrophic lateral sclerosis.Mar 31, 2022

Cigarette smoking is associated with increased risk for ALS. Jan 01, 1999

Coenzyme Q10 levels as high as 3,000 mg a day are safe and well-tolerated in ALS patients. Dec 13, 2005

Diaphragm training has value in amyotrophic lateral sclerosis.Nov 30, 2008

Existential well-being, as well as spirituality issues, perceived by SALS patients seems to be directly related with quality of life, severity of mood disturbance and burden experienced by their caregivers.Feb 28, 2011

Free testosterone is significantly decreased in ALS, indicating that supplementation with testosterone may have a therapeutic role in ALS treatment. Mar 15, 2002

Glutamate levels may contribute to the pathogenesis of ALS.Feb 01, 2010

High homocysteine levels are associated with neurodegenerative conditions such as Parkinson's disease, ALS and progressive supranuclear palsy.Jul 01, 2010

High homocysteine levels may be associated with the pathogenesis of neurological disorders.Jan 01, 2010

High plasma concentrations of organic pollutants negatively impact survival in amyotrophic lateral sclerosis.Feb 12, 2019

It is possible that lesions suggestive of Amyotrophic Lateral Sclerosis may be attributed to celiac disease. Mar 01, 2007

Lead exposure is a risk factor for amyotrophic lateral sclerosis.Jan 01, 2005

Methylcobalamin may prevent muscle wasting in amyotrophic lateral sclerosis.Dec 01, 1998

Occupational exposures to agricultural chemicals is associated with increased risk for ALS. Jun 15, 1997

Pesticide exposure is associated with an increased risk of amyotrophic lateral sclerosis.Jan 01, 2010

Progesterone levels correlate positively with survival and prognosis in ALS patients.Jan 01, 2011

Selenium, glutathione, copper/zinc and superoxide dismutase may have therapeutic value in ALS. Jan 01, 1995

Serum vitamin E levels have a protective effect on ALS risk.Apr 30, 2013

Significant neurological improvement in two patients with amyotrophic lateral sclerosis after 4 weeks of treatment with acupuncture injection point therapy using enercel.Nov 30, 2011

Statin drug use may be linked to neuromuscular diseases and an amyotrophic lateral sclerosis-like syndrome. Jan 01, 2007

Statin drugs may cause ALS-like neurodegeneration in susceptible individuals.Jan 01, 2009

Suboptimal vitamin D levels are frequently found in ALS patients (81%). Oct 31, 2013

There is an association between blood lead and the risk of amyotrophic lateral sclerosis.May 15, 2010

There is increased mitochondrial oxidative damage in patients with sporadic amyotrophic lateral sclerosisApr 15, 2008

These results strengthen the positive association between amyotrophic lateral sclerosis and extremely-low electromagnetic field exposure.Jan 01, 2017

This data provides new evidence that exposure to short-term air pollution may increase the risk of acute exacerbation of ALS.Dec 31, 2018

Tobacco consumption is associated with increased risk for ALS. Jan 15, 2000

Treadmill ambulation is feasible, tolerated and safe for patients for amyotrophic lateral sclerosis.Dec 01, 2010

Vitamin B12 as methylcobalamin significantly prolongs survival time in Amyotrophic Lateral Sclerosis. Oct 01, 2007

Vitamin E intake decreases the risk of amyotrophic lateral sclerosis: a pooled analysis of data from 5 prospective cohort studies..Mar 14, 2011

Vitamin E supplementation may contribute to preventing amyotrophic lateral sclerosis. Jan 01, 2005

Whey protein improves the condition of patients with amyotrophic lateral sclerosis.Apr 01, 2010

50-Hz magnetic field affects iron homeostasis in vitro.Jan 01, 2019

Fungal infection in neural tissue of patients with amyotrophic lateral sclerosis.Nov 30, 2017

Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG.Sep 01, 2007

Resveratrol's neural protective effects for the injured embryoid body and cerebral organoid.Jul 11, 2022

ALS untangled No. 17:"when ALS is lyme".Aug 31, 2012

Cannabis use is not uncommon in ALS patients who reported significant benefits from its use.Mar 01, 2004

Immunologic reactivity against Borrelia burgdorferi in patients with motor neuron disease.Apr 30, 1990

Lead toxicitity may be associated with ALS. May 01, 1998

Palmitoylethanolamide treatment led to an improved clinical picture.Oct 31, 2012

[ALS-like sequelae in chronic neuroborreliosis].Dec 31, 1994

"Galactooligosaccharide improves the animal survival and alleviates motor neuron death in SOD1G93A mouse model of amyotrophic lateral sclerosis."Aug 28, 2013

A cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis.Aug 07, 2006

Anti-inflammatory effects of a novel herbal extract in the muscle and spinal cord of an Amyotrophic lateral sclerosis.Dec 31, 2020

Bee venom attenuates neuroinflammatory events and extends survival in amyotrophic lateral sclerosis models.Dec 31, 2009

Branched chain amino acids may have a therapeutic role in ALS. Mar 31, 2011

Cannabinol may have therapeutic value in ameliorating symptoms in ALS. Sep 01, 2005

Cannabis contains a number of compounds which may have therapeutic value in delaying the progression of ALS. Mar 01, 2004

Caprylic triglyceride as a novel therapeutic approach to effectively improve the performance and attenuate the symptoms due to the motor neuron loss in ALS disease.Dec 31, 2011

Co-administration of IGF-I and glycosaminoglycans greatly delays motor neuron disease in the mouse model.Apr 01, 2002

Coenzyme Q10 demonstrated significant therapeutic effects in transgenic mouse model of ALS and Huntington's disease. Apr 01, 2002

Curcumin has anti-apoptotic properties in a transgenic amyotrophic lateral sclerosis mice.May 31, 2005

Dietary supplementation with S-adenosyl methionine delays the onset of motor neuron pathology in a murine model of amyotrophic lateral sclerosis.Feb 28, 2010

EGCG has multifunctional therapeutic effects in the mouse model of ALSOct 01, 2006

EGCG may provide a potential therapeutic candidate for ALS as a disease-modifying agent. Oct 01, 2007

Electroacupuncture reduces neuroinflammatory responses in symptomatic amyotrophic lateral sclerosis model.May 31, 2010

Estradiol slows neurodegeneration in a female mouse experimental model of amyotrophic lateral sclerosis.May 15, 2008

Extremely high dose vitamin D attenuates a feature of ALS, but not disease outcomes; also toxic to female mice. Dec 31, 2012

Female sex hormones such as estradiol and exercise have a possible neuroprotective role in female patients with ALS. Apr 01, 2009

Fisetin exerts antioxidant and neuroprotective effects in multiple mutant hsod1 models of amyotrophic lateral sclerosis.Mar 16, 2018

Genistein is neuroprotective in murine models of familial amyotrophic lateral sclerosis and stroke.May 19, 1999

Gingko biloba has a gender-specific neuroprotective effect in a transgenic mouse model of ALS. Aug 01, 2001

Glycoaminoglycans have neurotrophic and neuroregenerative effects in a mouse model of motor neuron disease.Mar 01, 1998

Glycosaminoglycans boost insulin-like growth factor-I-promoted neuroprotection, indicating their potential value in motor neuron disease and peripheral neuropathies.Jan 01, 1999

Motor Neuron Disease: Amyotrophic Lateral Sclerosis

View the Evidence:
137 Abstracts with Motor Neuron Disease: Amyotrophic Lateral Sclerosis Research