Myocardial Fibrosis

Name	AC	CK
Puerarin	6	15
Curcumin	7	13
Modified Citrus Pectin	2	12
Coenzyme Q10	1	10
Ginsenosides	6	10
Resveratrol	1	10
Selenium	1	10
Tanshinone IIA	6	9
Astragaloside	4	8
EGCG (Epigallocatechin gallate)	4	8
Flavonoids	4	8
Fucoxanthin	4	7
Salvia miltiorrhiza	3	7
Astaxanthin	1	5
Biochanin A	2	5
Cinnamaldehyde	1	5
Leonurine	4	5
Emodin	2	4
Licorice	2	4
Mangiferin	2	4
Rosmarinic acid	2	4
Safflower	2	4
Xanthones	2	4
Zerumbone	2	4
Apigenin	2	3
Asiatic Acid	2	3
Diosgenin	1	3
Lotus	2	3
Piperine	2	3
Piperlongumine	2	3
Berberine	1	2
Black Currant	1	2
Cafestol	1	2
Cannabidiol	1	2
Celastrol	1	2
Chlorogenic Acid	1	2
Cocoa	1	2
Crocin	1	2
Daidzein	1	2
Epicatechin	1	2
Fisetin	1	2
Fucoidan	1	2
Gallic Acid	1	2
Gastrodin	1	2
Ginger	1	2
Ginkgo biloba	1	2
Icariin	1	2
Liquiritigenin	1	2
Nicotinamide Mononucleotide	1	2
Nigella sativa (aka Black Seed)	1	2
Olive leaf extract	1	2
Paeoniflorin	1	2
Probiotics	1	2
Procyanidin B2	1	2
Pterostilbene	1	2
Quercetin	2	2
Red Sage	1	2
Rutin	1	2
Syringic Acid	1	2
Terminalia	1	2
Thymoquinone	1	2
Urolithin A	1	2
Ursolic Acid	1	2
Xanthohumol	2	2
Betulinic acid	1	1
Evodiamine	1	1
Gingerol	1	1
Magnolol	1	1
Naringenin	1	1
Plantago asiatica	1	1

Name	AC	CK
Isoproterenol	4	6
Arsenic Trioxide	1	3
Bisphenol S	1	2
Fructose	1	2
Polychlorinated biphenyls (PCBs)	1	2
Polystyrene nanoparticles	1	2
Nano Plastic-and Micro-Particles	1	1

Name	AC	CK	Focus
Traditional Chinese Medicine	1	2

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Pubmed Data : Phytomedicine. 2024 Jul 25 ;132:155891. Epub 2024 Jul 25. PMID: 39059093

Article Published Date : Jul 24, 2024

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Diosgenin

Diseases : Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective, Interleukin-6 Downregulation

Problem Substances : Arsenic Trioxide

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Salvianolic acid B ameliorates myocardial fibrosis in diabetic cardiomyopathy.Dec 09, 2023

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Pubmed Data : Int Immunopharmacol. 2019 Jun 26 ;74:105712. Epub 2019 Jun 26. PMID: 31254954

Article Published Date : Jun 25, 2019

Study Type : Animal Study

Additional Links

Substances : Asiatic Acid

Diseases : Hypertension, Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation

[+]

Astragaloside IV ameliorates isoprenaline-induced cardiac fibrosis.Dec 31, 2021

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Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:6841276. Epub 2022 May 9. PMID: 35586685

Article Published Date : Dec 31, 2021

Study Type : Animal Study

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Substances : Xanthones

Diseases : Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic, Cardioprotective

[+]

Berberine might become a new strategy for treating cardiac fibrosis in the future.Dec 31, 2014

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Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:4503747. Epub 2020 Dec 31. PMID: 33488743

Article Published Date : Dec 31, 2019

Study Type : Animal Study

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Substances : Cafestol

Diseases : Diabetes Mellitus: Type 1, Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic, Cardioprotective

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Cannabidiol alleviates right ventricular fibrosis by inhibiting the transforming growth factor β pathway.Jul 31, 2023

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Emodin alleviates cardiac fibrosis by suppressing activation of cardiac fibroblasts.Jun 30, 2019

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Pubmed Data : Acta Pharm Sin B. 2019 Jul ;9(4):724-733. Epub 2019 Apr 22. PMID: 31384533

Article Published Date : Jun 30, 2019

Study Type : Animal Study

Additional Links

Substances : Emodin

Diseases : Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic, Cardioprotective

[+]

Emodin ameliorates myocardial fibrosis.Dec 30, 2024

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Pubmed Data : Front Pharmacol. 2020 ;11:585163. Epub 2020 Nov 30. PMID: 33328989

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Inflammation, Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective

Problem Substances : Isoproterenol

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Gallic acid has therapeutic potential for the treatment of heart failure-induced pulmonary fibrosis.Nov 30, 2017

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Pubmed Data : Vascul Pharmacol. 2017 Dec ;99:74-82. Epub 2017 Oct 31. PMID: 29097327

Article Published Date : Nov 30, 2017

Study Type : Animal Study

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Substances : Gallic Acid

Diseases : Heart Failure, Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic

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Pubmed Data : Biomed Pharmacother. 2020 Jun ;126:110071. Epub 2020 Mar 12. PMID: 32172066

Article Published Date : May 31, 2020

Study Type : Animal Study

Additional Links

Substances : Modified Citrus Pectin

Diseases : Inflammation, Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective

[+]

Neferine may have antifibrogenic effects in diabetes-related cardiac fibrosis.Sep 19, 2016

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Pubmed Data : Oncotarget. 2016 Sep 20 ;7(38):61703-61715. PMID: 27533252

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Pubmed Data : Int J Med Sci. 2016 ;13(4):277-85. Epub 2016 Mar 30. PMID: 27076784

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Probiotics

Diseases : High Fat Diet, Myocardial Fibrosis

Pharmacological Actions : Autophagy Up-regulation, Cardioprotective

[+]

Paeoniflorin improves pressure overload-induced cardiac remodelling by modulating the MAPK signalling pathway in spontaneously hypertensive rats.Feb 28, 2019

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Pubmed Data : Phytomedicine. 2021 Feb ;82:153461. Epub 2021 Jan 6. PMID: 33497927

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Pubmed Data : Eur J Pharmacol. 2018 Aug 15 ;833:545-554. Epub 2018 Jun 18. PMID: 29913124

Article Published Date : Aug 14, 2018

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic, Cardioprotective

[+]

Pterostilbene attenuates fructose-induced myocardial fibrosis. Dec 31, 2018

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Pubmed Data : Shock. 2024 May 1 ;61(5):748-757. Epub 2024 Apr 15. PMID: 38662612

[+]

Treatment by Nigella sativa reduced myocardial fibrosis in inflammation-induced fibrosis.Jan 31, 2017

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Pubmed Data : Res Pharm Sci. 2017 Feb ;12(1):74-81. PMID: 28255317

Article Published Date : Jan 31, 2017

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic

Additional Keywords : Anti-Fibrotic, Inflammation, Lipopolysaccharide-Induced Toxicity, Myocardial Fibrosis, Nigella sativa (aka Black Seed)

[+]

Troxerutin reverses fibrotic changes in the myocardium of high-fat high-fructose diet-fed mice.Sep 01, 2015

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Pubmed Data : Mol Cell Biochem. 2015 Sep ;407(1-2):263-79. Epub 2015 Jun 16. PMID: 26077659

Article Published Date : Sep 01, 2015

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Int Med Res. 2019 Feb ;47(2):884-892. Epub 2019 Jan 11. PMID: 30632430

Article Published Date : Feb 01, 2019

Study Type : Animal Study

Additional Links

Diseases : Myocardial Fibrosis

Therapeutic Actions : Traditional Chinese Medicine

Pharmacological Actions : Anti-Fibrotic

Additional Keywords : Bodily Tissue Regeneration

[+]

6-gingerol ameliorates isoproterenol -induced myocardial fibrosis.Jun 30, 2020

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Pubmed Data : Mol Nutr Food Res. 2020 Jul ;64(13):e2000003. Epub 2020 Jun 8. PMID: 32438504

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Pubmed Data : Mol Med Rep. 2017 Nov ;16(5):6320-6325. Epub 2017 Aug 22. PMID: 28849070

Article Published Date : Oct 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Betulinic acid

Diseases : Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic, Cardioprotective

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Pubmed Data : Biomed Pharmacother. 2021 Jul ;139:111630. Epub 2021 May 1. PMID: 33945912

Article Published Date : Jun 30, 2021

Study Type : In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Heart Failure, Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic, Cardioprotective

[+]

Naringenin may become a novel strategy for treating cardiac fibrosis.Oct 31, 2017

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View the Evidence: 125 Abstracts with Myocardial Fibrosis Research

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Effects of resveratrol supplementation on cardiac remodeling in hypertensive patients.Feb 27, 2023

Galectin-3 inhibition with modified citrus pectin in hypertension. Dec 31, 2020

There was less fibrosis in elderly subjects supplemented with selenium and coenzyme Q10.Dec 07, 2017

Astaxanthin may be useful as a preventive/therapeutic agent for cardiac dysfunction and myocardial fibrosis.Mar 11, 2017

Cinnamaldehyde may be able to slow down the progression of cardiac fibrosis.Mar 20, 2017

Puerarin attenuates the endothelial-mesenchymal transition induced by oxidative stress in human coronary artery endothelial cells.Nov 04, 2020

Biochanin A inhibits cardiac hypertrophy and fibrosis in vivo and in vitro.Dec 31, 2023

Diosgenin alleviates arsenic trioxide induced cardiac fibrosis.Jul 24, 2024

Salvianolic acid B ameliorates myocardial fibrosis in diabetic cardiomyopathy.Dec 09, 2023

Acacetin inhibits the hypertension-associated cardiac fibrotic processes.Jun 21, 2023

Anti-fibrotic effects of curcumin and some of its analogues in the heart.Sep 10, 2019

Apigenin inhibits isoproterenol-induced myocardial fibrosis.Mar 10, 2022

Arjunolic acid, a peroxisome proliferator-activated receptor α agonist, regresses cardiac fibrosis by inhibiting non-canonical TGF-β signaling.Jan 05, 2017

Asiatic acid attenuates pressure overload-induced cardiac fibrosis.Jun 25, 2019

Astragaloside IV ameliorates isoprenaline-induced cardiac fibrosis.Dec 31, 2021

Astragaloside IV inhibits cardiac fibrosis via miR-135a-TRPM7-TGF-β/Smads pathway.Nov 14, 2019

AstragalosideⅣ was beneficial against cardiac fibrosis.Jun 30, 2017

Bellidifolin ameliorates isoprenaline-induced myocardial fibrosis.Dec 31, 2020

Bellidifolin ameliorates myocardial fibrosis.Dec 31, 2021

Berberine might become a new strategy for treating cardiac fibrosis in the future.Dec 31, 2014

Biochanin-A alleviates fibrosis and inflammation in cardiac injury.Jun 30, 2023

Bisphenol S exposure induces cardiac remodeling and aggravates high-fat diet-induced cardiac hypertrophy in mice.Nov 14, 2024

Blackcurrant improves diabetic cardiovascular dysfunction by reducing inflammatory cytokines.Nov 21, 2021

Cafestol inhibits high-glucose-induced cardiac fibrosis in cardiac fibroblasts and type 1-like diabetic rats.Dec 31, 2019

Cannabidiol alleviates right ventricular fibrosis by inhibiting the transforming growth factor β pathway.Jul 31, 2023

Cardiac hypertrophy and fibrosis were attenuated by olive leaf extract treatment in a rat model of diabetes.Nov 01, 2022

Cardioprotective effect of icariin against myocardial fibrosis and its molecular mechanism in diabetic cardiomyopathy.Sep 30, 2021

Celastrol relieves myocardial infarction-induced cardiac fibrosis.Jul 31, 2023

Chlorogenic acid alleviates hyperglycemia-induced cardiac fibrosis.Nov 16, 2020

Crocin attenuates isoprenaline-induced myocardial fibrosis.Aug 06, 2019

Curcumin attenuates cardiac fibrosis in spontaneously hypertensive rats through PPAR-γ activation.Sep 30, 2014

Curcumin improves cardiac fibrosis by inhibiting endothelial-mesenchymal transition through NRF2-DDAH-ADMA-NO pathway.Jan 31, 2022

Curcumin improves cardiac function and reduces cardiac fibrosis after myocardial infarction.Dec 31, 2020

Curcumin may have therapeutic value in treating aortic stenosis, left ventricular dysfunction and myocardial fibrosis. Mar 01, 2009

Curcumin protects against myocardial infarction-induced cardiac fibrosis.Dec 31, 2015

Daidzein suppresses TGF-β1-induced cardiac fibroblast activation.Mar 14, 2022

EGCG alleviates obesity-induced myocardial fibrosis.Dec 31, 2021

Emodin alleviates cardiac fibrosis by suppressing activation of cardiac fibroblasts.Jun 30, 2019

Emodin ameliorates myocardial fibrosis.Dec 30, 2024

Epicatechin ameliorates cardiac fibrosis in a female rat model of pre-heart failure with preserved ejection fraction.Jul 31, 2022

Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway.Nov 30, 2021

Epigallocatechin-3-gallate attenuates myocardial fibrosis in diabetic rats by activating autophagy.Jul 13, 2022

Epigallocatechin-3-O-gallate attenuated the endoglin expression and myocardial fibrosis in vitro and in vivo.Jun 15, 2016

Fisetin alleviates atrial inflammation, remodelling, and vulnerability to atrial fibrillation after myocardial infarction.Nov 29, 2019

Fucoidan and fucoxanthin in combination can potentially reduce cardiac hypertrophy, cardiac fibrosis, ROS level,Jan 20, 2019

Fucoxanthin ameliorated myocardial fibrosis in STZ-induced diabetic rats.Sep 21, 2022

Fucoxanthin regulates Nrf2/Keap1 signaling to alleviate myocardial hypertrophy in diabetes.May 19, 2022

Galangin attenuates isoproterenol-induced inflammation and fibrosis in the cardiac tissue.Dec 31, 2019

Gallic acid has therapeutic potential for the treatment of heart failure-induced pulmonary fibrosis.Nov 30, 2017

Gastrodin protects against cardiac hypertrophy and fibrosis.Dec 31, 2011

Ginger extract protects the heart against inflammation and fibrosis in diabetes.Sep 01, 2020

Ginsenoside Re inhibits myocardial fibrosis.Feb 28, 2023

Ginsenoside Rg2 alleviates myocardial fibrosis.Nov 30, 2021

Ginsenoside Rh2 is suitable to develop as an alternative remedy for cardiac fibrosis.Jun 25, 2017

Ginsenoside RH4 inhibits Ang II-induced myocardial remodeling by interfering with NFIL3.Feb 29, 2024

Gut bacterial metabolite Urolithin A inhibits myocardial fibrosis.Jan 07, 2022

Hydroxysafflor yellow A mitigates myocardial fibrosis induced by isoproterenol and angiotensin II.Dec 31, 2021

Leonurine attenuates myocardial fibrosis through upregulation of miR-29a-3p in mice post-myocardial infarction.Jan 31, 2021

Liquiritigenin attenuates isoprenaline‑induced myocardial fibrosisSep 30, 2021

Liquiritin protects against cardiac fibrosis after myocardial infarction.Dec 31, 2021

Low-dose PCB126 exposure disrupts cardiac metabolism and causes hypertrophy and fibrosis.Aug 30, 2021

Mangiferin activates Nrf2 to attenuate cardiac fibrosis via redistributing glutaminolysis-derived glutamate.Apr 26, 2020

Mangiferin ameliorates cardiac fibrosis in D-galactose-induced aging.Feb 28, 2021

Modified citrus pectin ameliorates myocardial fibrosis and inflammation.May 31, 2020

Neferine may have antifibrogenic effects in diabetes-related cardiac fibrosis.Sep 19, 2016

Nicotinamide mononucleotide attenuates isoproterenol-induced cardiac fibrosis.May 31, 2021

Nrf2 Is a key regulator on puerarin preventing cardiac fibrosis.Dec 31, 2017

Oral administration of probiotics may attenuate cardiomyocyte fibrosis and cardiac hypertrophy.Dec 31, 2015

Paeoniflorin improves pressure overload-induced cardiac remodelling by modulating the MAPK signalling pathway in spontaneously hypertensive rats.Feb 28, 2019

Pharmacological inhibition of SUMO-1 with ginkgolic acid alleviates cardiac fibrosis induced by myocardial infarction.Apr 14, 2018

Piperine attenuated cardiac fibrosis in mice.Mar 31, 2017

Piperlongumine attenuates angiotensin-II-induced cardiac hypertrophy and fibrosis.Jan 31, 2021

Myocardial Fibrosis

View the Evidence:
125 Abstracts with Myocardial Fibrosis Research