NSAID-induced toxicity

Name	AC	CK
Vitamin C	5	28
Flavonoids	13	27
Curcumin	14	24
Ginsenosides	12	23
NAC (N-acetyl-L-cysteine)	10	18
Dandelion	8	16
Vitamin E	6	16
Sulforaphane	5	14
Banana	4	12
Cinnamon	6	12
Nigella sativa (aka Black Seed)	6	12
Berberine	5	10
Enterococcus faecium	1	10
Lactobacillus gasseri	1	10
Lactobacillus rhamnosus	1	10
Yoghurt	1	10
Fucoidan	5	9
Resveratrol	5	9
Fisetin	4	8
Palm Tree	2	8
Polyphenols	4	8
Silymarin	4	8
Apigenin	3	6
Astaxanthin	3	6
Cardamom	2	6
Chrysin	3	6
Hydrogen Water	3	6
Moringa oleifera	3	6
Mululuza	3	6
Pomegranate	2	6
Pterostilbene	3	6
Rosmarinic acid	3	6
Selenium	3	6
Tanshinone IIA	4	6
Thymoquinone	3	6
Burdock	3	5
Citrus naringin	3	5
Lemon	3	5
Licorice	3	5
Allicin	2	4
Alpha-Lipoic Acid	2	4
Artichoke	2	4
Astragaloside	2	4
Baccharis trimera	2	4
Basil	2	4
Caffeic Acid	2	4
Carotenoids	2	4
Chlorogenic Acid	2	4
EGCG (Epigallocatechin gallate)	2	4
Echinacea	2	4
Frankincense	2	4
Fructose	1	4
Fucoxanthin	2	4
Ginkgo biloba	2	4
Glucose	1	4
Glycyrrhizin	2	4
Grape Seed Extract	2	4
Hesperidin	2	4
Honey	1	4
Honokiol	2	4
Lycopene	2	4
Maltose	1	4
Milk Thistle	2	4
Mulberry	2	4
Mussel: Green-lipped (Perna canaliculus)	1	4
Orchid	2	4
Paeoniflorin	2	4
Panax Ginseng	2	4
Passion Flower	2	4
Poria cocos	2	4
Prickly Pear Cactus	2	4
Quercetin	2	4
Rosemary	2	4
Schisandra	2	4
Silibinin	2	4
Sinomenine	2	4
Sophora Flavescens	2	4
Soursop	2	4
Spirulina	2	4
Sucrose	1	4
White Clover	2	4
Zataria multiflora	2	4
Carvacrol	2	3
Diallyl sulfide	2	3
Ferulic acid	1	3
Goji	2	3
Honeysuckle	2	3
Kaempferol	2	3
Naringenin	2	3
Rose	2	3
Saffron	2	3
Salvia miltiorrhiza	1	3
Shikonin	2	3
Thymol	2	3
Turmeric	2	3
6-Shogaol	1	2
Acacia catechu	1	2
Achiote	1	2
Algae	1	2
Aloe Vera	1	2
Amygdalin	1	2
Andrographis	1	2
Andrographolide	1	2
Anthocyanins	1	2
Apple Polyphenols	1	2
Apples	1	2
Artesunate	1	2
Avocado	1	2
Bael	1	2
Bamboo	1	2
Bee Propolis	1	2
Bergamot	1	2
Beta-glucan	1	2
Betanin	1	2
Bifidobacterium Longum	1	2
Bitter Apple	1	2
Bixin	1	2
Black Tea	1	2
Boswellic Acid	1	2
Broccoli Sprouts	1	2
Butterfly Pea	1	2
Carbon 60	1	2
Carnosic Acid	1	2
Carnosine	1	2
Catechols	1	2
Celery	1	2
Chamomile	1	2
Chives	1	2
Chlorella (Algae)	1	2
Citrus Triterpenoids	1	2
Coconut Water	1	2
Coenzyme Q10	1	2
Corn Silk	1	2
Cumin	1	2
D-Limonene	1	2
Date Seeds	1	2
Dates	1	2
Emodin	1	2
Eriodictyol	1	2
Folic Acid	1	2
Garden Cress (Lepidium sativum)	1	2
Garlic	1	2
Gastrodin	1	2
Genistein	1	2
Geranium	1	2
Germanium	1	2
Ginger	1	2
Gingerol	1	2
Ginseng (American)	1	2
Gold (nanoparticles)	1	2
Goldenseal	1	2
Gotu Kola	1	2
Guava	1	2
Histidine	1	2
Horse Chestnut	1	2
Isoflavones	1	2
Jujube	1	2
Juniper	1	2
Kombucha Tea	1	2
Lactobacillus casei	1	2
Lactococcus lactis	1	2
Leonurine	1	2
Lignans	1	2
Liquiritigenin	1	2
Loquat	1	2
Loquat Seeds	1	2
Luteolin	1	2
MSM (Methylsulfonylmethane)	1	2
Magnesium	1	2
Mangiferin	1	2
Mango	1	2
Melatonin	1	2
Methionine	1	2
Mucuna pruriens (aka Velvet Beans)	1	2
Neem	1	2
Nicotinamide	1	2
Nicotinamide adenine dinucleotide (NADH)	1	2
Nobiletin	1	2
Nutmeg	1	2
Olive Oil	1	2
Omega-3 Fatty Acids	1	2
Orange: Mandarin	1	2
Organosulfur Compounds	1	2
P-Coumaric Acid	1	2
Paeonol	1	2
Panax Notoginseng	1	2
Papaya	1	2
Parsley	1	2
Peony	1	2
Phellinus Linteus	1	2
Phosphatidylcholine	1	2
Phyllanthus urinaria	1	2
Piperine	1	2
Plantago major	1	2
Pomegranate Peel	1	2
Probiotics	1	2
Propolis: Brazillian	1	2
Prunella vulgaris	1	2
Pumpkin Seed Oil/Meal	1	2
Pycnogenol (Pine Bark)	1	2
Radish	1	2
Rosemaric Acid	1	2
Rubia Cordifolia	1	2
Rutin	1	2
Safflower	1	2
Sage	1	2
Satsuma	1	2
Scopoletin	1	2
Seaweed	1	2
Sembung Leaf	1	2
Sesamin	1	2
Sesamol	1	2
Shiitake Mushroom	1	2
Silver (nanoparticles)	1	2
St. Johns Wort	1	2
Syringic Acid	1	2
Tea	1	2
Terminalia	1	2
Terminalia chebula	1	2
Testosterone	1	2
Thyme	1	2
Tocotrienols	1	2
Tongkat Ali	1	2
Toona sinensis	1	2
Tribulus	1	2
Turkey Tail Mushroom	1	2
Urolithin A	1	2
Vitamin B-12	1	2
Vitamin D	1	2
Vitamin K	1	2
Walnut	1	2
Water: Deep Sea	1	2
Watercress	1	2
Wheat Grass	1	2
Wogonin	1	2
Woodfordia fruticosa	1	2
Xanthohumol	1	2
Yellow Sweet Clover (Melilotus officinalis)	1	2
Zerumbone	1	2
Zucchini	1	2
beta-Carotene	1	2
Cannabinoids	1	1
Citrus Peel	1	1
Curcuminoids	1	1
Ginseng	1	1
Ginseng (Korean)	1	1
Lactobacillus fermentum	1	1
Lotus	1	1
Purslane	1	1
Reishi Mushroom	1	1
Tangeretin	1	1
Tetrahydrocurcumin	1	1
Tryptophan	1	1

Name	AC	CK
Acetaminophen	447	1295
Paracetamol	402	1180
Aspirin	41	157
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	13	77
Tylenol	9	57
Ibuprofen	7	40
Diclofenac	5	34
Analgesic: Non-opioid	2	12
Antibiotics	3	12
Celecoxib	1	10
Diphenhydramine	1	10
Naproxen	1	10
Rofecoxib	1	10
Indomethacin	3	8
Endocrine Disruptors	2	7
Atorvastatin	1	2
Endocrine Disrupting Chemicals (EDCs)	1	2
High Fructose Corn Syrup	1	2
Plutonium 238	1	2
Statin Drugs	1	2
Uranium	1	2
Allopurinol	1	1
Bisphenol A	1	1
Cadmium	1	1
Cisplatin	1	1
Dioxins	1	1
Doxorubicin	1	1
Gentamicin	1	1
Glyphosate	1	1
Lead	1	1
Pesticides	1	1
Phthalates	1	1

Name	AC	CK
Acupuncture	1	10
Ozone Therapy	2	4
Exercise	1	2
Hyperbaric Treatment	1	2
Photobiomodulation	1	2

Name	AC	CK	Focus
Vaccination: All	2	7

[+]

Acetaminophen use and the risk of asthma in children and adults.Oct 31, 2009

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Pubmed Data : Chest. 2009 Nov ;136(5):1316-1323. Epub 2009 Aug 20. PMID: 19696122

Article Published Date : Oct 31, 2009

Study Type : Meta Analysis, Review

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Prenatal paracetamol use and asthma in childhood: A systematic review and meta-analysis.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Autism. 2008 May;12(3):293-307. PMID: 18445737

Article Published Date : May 01, 2008

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Autism Spectrum Disorders

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Tylenol

[+]

Problem Substances : Acetaminophen, Paracetamol

[+]

Associations between cord blood acetaminophen biomarkers and childhood asthma with and without allergic comorbidities.May 31, 2024

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Ann Allergy Asthma Immunol. 2024 Jun ;132(6):705-712.e5. Epub 2024 Mar 12. PMID: 38484838

Article Published Date : May 31, 2024

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Asthma

Problem Substances : Acetaminophen, Paracetamol

[+]

Associations of acetaminophen use during pregnancy and the first year of life with neurodevelopment in early childhood.Apr 30, 2020

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Pubmed Data : Am J Emerg Med. 2015 Jun ;33(6):749-53. Epub 2015 Feb 25. PMID: 25827597

Pubmed Data : Scand J Gastroenterol. 2022 May 9:1-7. Epub 2022 May 9. PMID: 35534443

Article Published Date : May 08, 2022

Study Type : Human Study

Additional Links

Substances : Enterococcus faecium, Lactobacillus rhamnosus

Diseases : Aspirin-Induced Toxicity

Pharmacological Actions : Gastroprotective

Problem Substances : Aspirin

[+]

Long-term prenatal exposure to paracetamol is associated with DNA methylation differences in children diagnosed with ADHD.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Maternal use of acetaminophen during pregnancy and neurobehavioral problems in offspring at 3 years.Dec 31, 2021

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Pubmed Data : PLoS One. 2022 ;17(9):e0272593. Epub 2022 Sep 28. PMID: 36170224

Article Published Date : Dec 31, 2021

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Disorder with Hyperactivity, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sonsDec 31, 2016

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Pubmed Data : Hum Reprod. 2017 Jan ;32(1):223-231. Epub 2016 Nov 16. PMID: 27852690

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Brain Behav. 2015 Aug ;5(8):e00338. Epub 2015 May 29. PMID: 26357585

Article Published Date : Jul 31, 2015

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Cardiac Mortality , Inflammation

Additional Keywords : Increased Risk, Mortality, Synergistic Toxicity

Problem Substances : Acetaminophen, Diclofenac, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Paracetamol

[+]

Patients with RA appear to have less capacity for excreting paracetamol as non-toxic conjugates and may be more susceptible to paracetamol toxicity.Apr 30, 1991

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Pubmed Data : Xenobiotica. 1991 May ;21(5):689-93. PMID: 1949902

Article Published Date : Apr 30, 1991

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Rheumatoid Arthritis

Problem Substances : Acetaminophen, Paracetamol

[+]

Prenatal acetaminophen exposure was associated with a greater number of autism spectrum symptoms in males.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Epidemiol. 2016 12 1 ;45(6):1987-1996. PMID: 27353198

Article Published Date : Dec 31, 2015

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Autism Spectrum Disorders, Prenatal Chemical Exposures

Additional Keywords : Risk Factors

Problem Substances : Acetaminophen, Paracetamol

[+]

Prenatal acetaminophen was associated with adverse birth outcomes.Dec 31, 2021

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Pubmed Data : Int J Epidemiol. 2013 Dec ;42(6):1702-13. Epub 2013 Oct 24. PMID: 24163279

Pubmed Data : Eur Heart J Cardiovasc Pharmacother. 2016 Dec 26. Epub 2016 Dec 26. PMID: 28025218

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Pubmed Data : Int J Biochem Cell Biol. 2005 Aug ;37(8):1727-37. Epub 2005 Apr 26. PMID: 15878691

Article Published Date : Aug 01, 2005

Study Type : Human In Vitro

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Enzyme Inhibitors

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Acetaminophen

[+]

Acetaminophen toxicity induces mitochondrial complex I inhibition in human liver tissue.Aug 11, 2019

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Pubmed Data : Basic Clin Pharmacol Toxicol. 2019 Aug 12. Epub 2019 Aug 12. PMID: 31403256

Article Published Date : Aug 11, 2019

Study Type : Animal Study, Human In Vitro

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Problem Substances : Acetaminophen

[+]

The results of this in vitro study suggested that high doses of acetaminophen may cause serious damage towards human mesenchymal stem cells.Jun 18, 2015

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Pubmed Data : Int J Mol Med. 2015 Jun 19. Epub 2015 Jun 19. PMID: 26096646

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Pubmed Data : Cureus. 2019 Nov 27 ;11(11):e6251. Epub 2019 Nov 27. PMID: 31890447

Article Published Date : Nov 26, 2019

Study Type : Human: Case Report

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Protection of taraxasterol against acetaminophen-induced liver injury.Jul 24, 2023

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Pubmed Data : Phytomedicine. 2023 Jul 25 ;116:154872. Epub 2023 May 13. PMID: 37209606

Article Published Date : Jul 24, 2023

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Dandelion

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen

[+]

Rosemary extract protects liver mitochondria from oxidative damage and prevents acetaminophen-induced hepatotoxicity.Mar 02, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antioxidants (Basel). 2023 Mar 3 ;12(3). Epub 2023 Mar 3. PMID: 36978874

Article Published Date : Mar 02, 2023

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Rosemary

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen

[+]

Salvianolic acid A protects against acetaminophen-induced hepatotoxicity.Apr 02, 2023

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Pubmed Data : Antioxidants (Basel). 2023 Apr 3 ;12(4). Epub 2023 Apr 3. PMID: 37107244

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Pubmed Data : J Ayub Med Coll Abbottabad. 2020 Jan- Mar;32(1):28-32. PMID: 32468750

Problem Substances : Acetaminophen, Paracetamol

[+]

A. lappa could protect the liver cells from carbon tetrachloride or acetaminophen-induced liver damages.Dec 31, 1999

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Pubmed Data : Am J Chin Med. 2000 ;28(2):163-73. PMID: 10999435

Article Published Date : Dec 31, 1999

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Pubmed Data : Pharmacol Biochem Behav. 2018 Dec ;175:146-151. Epub 2018 Oct 22. PMID: 30359628

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Pubmed Data : J Clin Endocrinol Metab. 2022 May 17 ;107(6):1647-1661. PMID: 35147701

Article Published Date : May 16, 2022

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Acetaminophen toxicity is substantially reduced by beta-carotene in mice.Dec 31, 1994

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Pubmed Data : Int J Vitam Nutr Res. 1995 ;65(3):175-80. PMID: 8829996

Article Published Date : Dec 31, 1994

Study Type : Animal Study

Additional Links

Substances : beta-Carotene, Carotenoids

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Acetaminophen toxicity to cultured rat embryos.Dec 31, 1989

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Pubmed Data : Teratog Carcinog Mutagen. 1990 ;10(5):361-71. PMID: 1981948

Allicin and omega-3 fatty acids attenuates acetaminophen mediated renal toxicity.Jul 11, 2023

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Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2023 Jul 12. Epub 2023 Jul 12. PMID: 37436496

Article Published Date : Jul 11, 2023

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Pubmed Data : Open Vet J. 2024 Jan ;14(1):292-303. Epub 2024 Jan 31. PMID: 38633147

Article Published Date : Dec 31, 2023

Study Type : Animal Study

Additional Links

Substances : Berberine, Selenium

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen

[+]

Ameliorative effects of corn silk extract on acetaminophen-induced renal toxicity.Dec 31, 2020

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Pubmed Data : Environ Sci Pollut Res Int. 2021 Jan ;28(2):1762-1774. Epub 2020 Aug 27. PMID: 32856245

Article Published Date : Dec 31, 2020

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Pubmed Data : J Food Drug Anal. 2017 Oct ;25(4):862-871. Epub 2016 Nov 5. PMID: 28987363

Article Published Date : Sep 30, 2017

Study Type : Animal Study

Additional Links

Substances : Mulberry

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents

Problem Substances : Acetaminophen, Paracetamol

[+]

An isoflavonoid from seeds of Lepidium sativum L. has a protective effect on hepatotoxicity induced by paracetamol.Dec 31, 2013

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Pubmed Data : Molecules. 2014 ;19(10):15440-51. Epub 2014 Sep 26. PMID: 25264831

Article Published Date : Dec 31, 2013

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Pubmed Data : Mar Drugs. 2023 Nov 14 ;21(11). Epub 2023 Nov 14. PMID: 37999416

Article Published Date : Nov 13, 2023

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Pubmed Data : Phytother Res. 2011 Dec 14. Epub 2011 Dec 14. PMID: 22170791

Article Published Date : Dec 14, 2011

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Alcohol Toxicity , Aspirin-Induced Toxicity , Gastric Ulcer

Pharmacological Actions : Anti-Ulcer Agents, Gastroprotective

[+]

Astaxanthin provided protection for the liver against acetaminophen hepatotoxicity.Jan 29, 2017

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Pubmed Data : Int Immunopharmacol. 2017 Jan 30 ;45:26-33. Epub 2017 Jan 30. PMID: 28152447

Article Published Date : Jan 29, 2017

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Bixin loaded solid lipid nanoparticles for enhanced hepatoprotection--preparation, characterisation and in vivo evaluation.Sep 30, 2014

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Pubmed Data : Int J Pharm. 2014 Oct 1 ;473(1-2):485-92. Epub 2014 Jul 24. PMID: 25066077

Article Published Date : Sep 30, 2014

Study Type : Animal Study

Additional Links

Substances : Bixin

Diseases : Acetaminophen (Tylenol) Toxicity , Lipid Peroxidation, Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Black ginseng has ameliorative effects against acetaminophen induced hepatotoxicity.Apr 20, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2017 Apr 21 ;22(4). Epub 2017 Apr 21. PMID: 28430162

Article Published Date : Apr 20, 2017

Study Type : Animal Study

Additional Links

Substances : Ginsenosides, Panax Ginseng

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Additional Keywords : Phytotherapy

Problem Substances : Acetaminophen, Paracetamol

[+]

Both the lower and higher dose exposures resulted in measurable changes in lung morphometrics, with the lower dose exposure causing alveolar wall thinning.Oct 31, 2021

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Pubmed Data : Am J Physiol Lung Cell Mol Physiol. 2021 Nov 1 ;321(5):L941-L953. Epub 2021 Sep 29. PMID: 34585971

Article Published Date : Oct 31, 2021

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Lung Damage

Problem Substances : Acetaminophen, Paracetamol

[+]

Brazilian green propolis suppresses acetaminophen-induced hepatocellular necrosis.Sep 30, 2018

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Pubmed Data : J Toxicol Pathol. 2018 Oct ;31(4):275-282. Epub 2018 Jul 1. PMID: 30393431

Article Published Date : Sep 30, 2018

Study Type : Animal Study

Additional Links

Substances : Propolis: Brazillian

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Broccoli sprout extract protected the liver from various types of xenobiotic substances through induction of detoxification enzymes and glutathione synthesis.Sep 20, 2015

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Pubmed Data : World J Gastroenterol. 2015 Sep 21 ;21(35):10091-103. PMID: 26401074

Article Published Date : Sep 20, 2015

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Corylin exhibited favorable safety profiles and significant hepatoprotective effects in mice with APAP-induced liver injury.Dec 14, 2025

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Pubmed Data : Bioorg Med Chem. 2025 Dec 15 ;131:118433. Epub 2025 Oct 6. PMID: 41066958

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Pubmed Data : BMC Complement Altern Med. 2014 Mar 3 ;14:81. Epub 2014 Mar 3. PMID: 24589018

Article Published Date : Mar 02, 2014

Study Type : Animal Study

Additional Links

Substances : Hydrogen Water

Diseases : Aspirin-Induced Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Gastroprotective

Problem Substances : Aspirin

[+]

Dual anti-inflammatory effects of curcumin and berberine on acetaminophen-induced liver injury.Nov 18, 2024

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Pubmed Data : Biochem Biophys Res Commun. 2024 Nov 19 ;734:150772. Epub 2024 Sep 30. PMID: 39362031

Article Published Date : Nov 18, 2024

Study Type : Animal Study

Additional Links

Substances : Berberine, Curcumin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Early exposure to paracetamol reduces level of testicular testosterone and changes gonadal expression of genes relevant for steroidogenesis in rats offspring.Jun 30, 2022

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Pubmed Data : Drug Chem Toxicol. 2022 Jul ;45(4):1862-1869. Epub 2021 Mar 3. PMID: 33657953

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Pubmed Data : Int J Dev Neurosci. 2015 Dec ;47(Pt B):133-9. Epub 2015 Sep 25. PMID: 26390956

Article Published Date : Nov 30, 2015

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

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Problem Substances : Aspirin

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Elderly mice with history of acetaminophen intoxication display worsened cognitive impairment and persistent elevation of astrocyte and microglia burden.Jun 19, 2024

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Pubmed Data : Sci Rep. 2024 Jun 20 ;14(1):14205. Epub 2024 Jun 20. PMID: 38902507

Article Published Date : Jun 19, 2024

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Aging, Cognitive Decline/Dysfunction

Problem Substances : Acetaminophen, Paracetamol

[+]

Emodin attenuates acetaminophen-induced hepatotoxicity via the cGAS-STING pathway.Aug 17, 2021

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Pubmed Data : Inflammation. 2021 Aug 18. Epub 2021 Aug 18. PMID: 34409550

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Pubmed Data : An Acad Bras Cienc. 2018 Aug ;90(2 suppl 1):2347-2358. Epub 2018 Jun 25. PMID: 29947676

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Pubmed Data : Drug Deliv. 2022 Dec ;29(1):3256-3269. PMID: 36321805

Article Published Date : Nov 30, 2022

Study Type : Animal Study

Additional Links

Substances : Naringenin

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Evaluation of the reparative effect of sinomenine in an acetaminophen-induced liver injury model.Jan 20, 2024

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Pubmed Data : Curr Issues Mol Biol. 2024 Jan 21 ;46(1):923-933. Epub 2024 Jan 21. PMID: 38275673

Article Published Date : Jan 20, 2024

Study Type : Animal Study

Additional Links

Substances : Sinomenine

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Even when taken in small doses, paracetamol causes changes in liver metabolism when taken for an extended period of time.Sep 30, 2007

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Pubmed Data : Exp Toxicol Pathol. 2007 Oct ;59(2):139-41. Epub 2007 Jun 29. PMID: 17601712

Article Published Date : Sep 30, 2007

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Problem Substances : Acetaminophen, Paracetamol

[+]

Exploration of the protective mechanism of naringin in the acetaminophen-induced hepatic injury by metabolomics.Dec 31, 2021

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Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:7138194. Epub 2022 Sep 16. PMID: 36160708

Article Published Date : Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biology (Basel). 2021 Oct 14 ;10(10). Epub 2021 Oct 14. PMID: 34681141

Article Published Date : Oct 13, 2021

Study Type : Animal Study

Additional Links

Substances : Olive Oil

Diseases : Acetaminophen (Tylenol) Toxicity , Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Antioxidants

Problem Substances : Acetaminophen, Paracetamol

[+]

Extract of Triticum aestivum sprouts suppresses acetaminophen-induced hepatotoxicity in mice.Oct 19, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2021 Oct 20 ;26(21). Epub 2021 Oct 20. PMID: 34770745

Article Published Date : Oct 19, 2021

Study Type : Animal Study

Additional Links

Substances : Wheat Grass

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Extracts of J. communis leaves was found to be potent antioxidant and hepatoprotective without any cytotoxicity.Dec 31, 2016

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Fucoidan alleviates acetaminophen-induced hepatotoxicity.Dec 13, 2018

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Pubmed Data : Int J Mol Sci. 2018 Dec 14 ;19(12). Epub 2018 Dec 14. PMID: 30558169

Article Published Date : Dec 13, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Fucoidan

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen

[+]

Fucoidan exhibits a gastro-protective effect against aspirin-induced ulceration in rats.Jan 31, 2011

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Pubmed Data : Int Immunopharmacol. 2011 Feb ;11(2):157-63. Epub 2010 Nov 26. PMID: 21084063

Article Published Date : Jan 31, 2011

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Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:4619064. Epub 2022 Aug 10. PMID: 35990838

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen

[+]

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Pubmed Data : Biochem Biophys Res Commun. 2020 Jun 18 ;527(1):90-97. Epub 2020 Apr 27. PMID: 32446397

Ginsenoside Rg1 prevents acetaminophen-induced oxidative stress and apoptosis.Jan 03, 2019

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Pubmed Data : J Asian Nat Prod Res. 2019 Jan 4:1-16. Epub 2019 Jan 4. PMID: 30608002

Article Published Date : Jan 03, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenoside Rg1 protects against acetaminophen-induced liver injury.Jul 16, 2018

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Pubmed Data : Regul Toxicol Pharmacol. 2018 Jul 17 ;98:58-68. Epub 2018 Jul 17. PMID: 30030101

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Pubmed Data : J Agric Food Chem. 2017 Oct 25 ;65(42):9226-9236. Epub 2017 Oct 16. PMID: 28965396

Article Published Date : Oct 24, 2017

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Hepatoprotective, Malondialdehyde Down-regulation

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenoside Rk1 ameliorates paracetamol-induced hepatotoxicity.Dec 31, 2018

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Pubmed Data : Arch Biochem Biophys. 1999 Sep 1;369(1):42-58. PMID: 10462439

Article Published Date : Sep 01, 1999

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Apoptotic, Antioxidants

Additional Keywords : Proanthocyanidins

[+]

Grape seeds extract provided biochemical and histo-pathological improvement in paracetamol induced renal cortical toxicity. Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Bratisl Lek Listy. 2017 ;118(4):233-242. PMID: 28471235

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Medicina (Kaunas). 2019 May 21 ;55(5). Epub 2019 May 21. PMID: 31117289

Article Published Date : May 20, 2019

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid, Silibinin, Vitamin C

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidant, Hepatoprotective

Additional Keywords : Natural Substance Synergy

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective activity and nephroprotective activity of peel extract from three varieties of the passion fruit.Feb 27, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Med Food. 2006 ;9(4):524-30. PMID: 17201640

Article Published Date : Dec 31, 2005

Study Type : Animal Study

Additional Links

Substances : Mululuza

Diseases : Acetaminophen (Tylenol) Toxicity , Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Baganda Traditional Medicine, Phytotherapy, Plant Extracts

Problem Substances : Acetaminophen

[+]

Hepatoprotective and antioxidant activity of watercress extract on acetaminophen-induced hepatotoxicity.Jun 30, 2019

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Pubmed Data : Malays J Med Sci. 2018 Mar ;25(2):64-71. Epub 2018 Apr 27. PMID: 30918456

Article Published Date : Feb 28, 2018

Study Type : Animal Study

Additional Links

Substances : Zerumbone

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective potential of Clitoria ternatea leaf extract against paracetamol induced damage in mice.Dec 05, 2011

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2011 Dec 6 ;16(12):10134-45. Epub 2011 Dec 6. PMID: 22146374

Article Published Date : Apr 23, 2021

Study Type : Animal Study

Additional Links

Substances : Safflower

Diseases : Acetaminophen (Tylenol) Toxicity , Thrombosis

Pharmacological Actions : Detoxifier

Problem Substances : Acetaminophen

[+]

Hyperbaric oxygen treatment and N-acetylcysteine ameliorate acetaminophen-induced liver injury in a rat model. Sep 30, 2013

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Pubmed Data : Hum Exp Toxicol. 2013 Oct ;32(10):1107-16. Epub 2013 Aug 7. PMID: 23925941

Article Published Date : Sep 30, 2013

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Therapeutic Actions : Hyperbaric Treatment

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

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The Following are Sub-Topics of NSAID-induced toxicity

View the Evidence: 567 Abstracts with NSAID-induced toxicity Research

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Acetaminophen use and the risk of asthma in children and adults.Oct 31, 2009

Prenatal paracetamol use and asthma in childhood: A systematic review and meta-analysis.Dec 31, 2016

The use of paracetamol during pregnancy is associated with an increased risk of childhood asthma.Mar 31, 2011

Prevalence of hypersensitivity reactions in children associated with acetaminophen.Dec 31, 2017

This analysis suggests Helicobacter pylori increases the risk of low-dose aspirin ulcers.Nov 07, 2018

Paracetamol metabolism by endothelial cells - Potential mechanism underlying intravenous paracetamol-induced hypotension.Dec 31, 2024

Acetaminophen and diphenhydramine premedication for for allergic and febrile nonhemolytic transfusion reactions may be ineffective and unsafe. Jan 01, 2007

Acetaminophen changes Mu rhythm power related to pain empathy.Jun 05, 2023

Acetaminophen elevates unbound bilirubin levels by the glucose oxidase-peroxidase method.Aug 31, 2021

Acetaminophen exposure during pregnancy was associated with childhood asthmatic symptoms among vulnerable subgroups in this cohort.Sep 25, 2021

Acetaminophen use after measles-mumps-rubella vaccination is associated with autistic disorder.May 01, 2008

Acetaminophen use during pregnancy and DNA methylation in the placenta of the extremely low gestational age newborn.Mar 31, 2019

Acetaminophen use during pregnancy is associated with an increased risk for ADHD, ASD, and hyperactivity symptoms.Jul 31, 2018

Acetaminophen use for fever in children associated with autism spectrum disorder.Mar 31, 2016

Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers.Nov 30, 1990

Aspirin use is associated with a higher rate of vitamin B12 deficiency in patients hospitalized with cardiovascular disease.Oct 01, 2004

Association of acetaminophen use during pregnancy with behavioural problems in childhood.Sep 30, 2016

Association of prenatal acetaminophen exposure measured in meconium with risk of attention-deficit/hyperactivity disorder.Oct 31, 2020

Association of prenatal acetaminophen use and acetaminophen metabolites with DNA methylation of newborns.Dec 31, 2021

Associations between cord blood acetaminophen biomarkers and childhood asthma with and without allergic comorbidities.May 31, 2024

Associations of acetaminophen use during pregnancy and the first year of life with neurodevelopment in early childhood.Apr 30, 2020

Autism may be associated with the use of acetaminophen in children. Dec 01, 2009

Chronic tylenol use is associated wtih an almost two-fold increased risk of blood cancer.May 09, 2011

Comparison of the efficacy of diclofenac, acupuncture, and acetaminophen in the treatment of renal colic.May 31, 2015

Decline of aspirin use is associated with a decreased incidence of Reye's syndrome.Jun 01, 1987

Drug-induced liver toxicity (particularly acetaminophen-induced liver toxicity) has replaced viral hepatitis as the most single frequent cause of acute liver failutre in ubran Sep 01, 2009

Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults.May 31, 2000

Exposure to paracetamol in utero was associated with increased risks of motor milestone delay and impaired communication skills in children at 18 months.Nov 30, 2016

Gestational exposure to acetaminophen was associated with a small increased risk of ADHD.Sep 29, 2025

Harmful effects of NSAIDs among patients with hypertension and coronary artery disease include increased cardiac mortality. Jul 01, 2011

Higher paracetamol levels are associated with elevated glucocorticoid concentrations in hair.Jun 30, 2024

Lactobacillus complex capsules ameliorate aspirin-related small intestinal mucosal injury: a prospective, randomized, controlled clinical trial.May 08, 2022

Long-term prenatal exposure to paracetamol is associated with DNA methylation differences in children diagnosed with ADHD.Dec 31, 2016

Male urinary paracetamol and semen quality.Oct 31, 2017

Maternal acetaminophen biomarkers were specifically associated with increased risk of ADHD diagnosis in offspring. Jul 02, 2018

Maternal acetaminophen use and cognitive development at 4 years.Feb 28, 2023

Maternal acetaminophen use during pregnancy is associated with a higher risk for hyperkinetic disorders and ADHD-like behaviors in children.Mar 31, 2014

Maternal acetaminophen use during pregnancy was associated with lower performance IQ in 5-year olds.Oct 31, 2016

Maternal exposure to paracetamol is associated with disadvantages to the offspring in scholastic abilities such as mathematics and reading at secondary school ages.Dec 31, 2022

Maternal paracetamol use during pregnancy could be associated with poorer attention and executive function in 5-year-olds.Nov 30, 2016

Maternal paracetamol use in pregnancy is associated with an enhanced risk of asthma and wheezing in their children.Feb 23, 2023

Maternal use of acetaminophen during pregnancy and neurobehavioral problems in offspring at 3 years.Dec 31, 2021

Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sonsDec 31, 2016

More than half of patients who present at the hospital with acetaminophen-induced liver damage or liver failure have undetectable levels of acetaminophen.Feb 04, 2019

Paracetamol use during pregnancy was associated with an increased risk of asthma and wheezing in childhood.May 31, 2008

Paracetamol was associated with increased mortality, especially cardiovascular.Jul 31, 2015

Patients with RA appear to have less capacity for excreting paracetamol as non-toxic conjugates and may be more susceptible to paracetamol toxicity.Apr 30, 1991

Prenatal acetaminophen exposure was associated with a greater number of autism spectrum symptoms in males.Dec 31, 2015

Prenatal acetaminophen was associated with adverse birth outcomes.Dec 31, 2021

Prenatal and early-life antibiotic exposure and the risk of atopic dermatitis in children.Apr 30, 2023

Prenatal and infant paracetamol exposure and development of asthma.Mar 31, 2016

Prenatal exposure to acetaminophen and children's language development at 30 months.May 31, 2018

Prenatal exposure to acetaminophen increases the risk of atopic dermatitis in children.Jun 30, 2021

Prenatal paracetamol exposure and child neurodevelopment.Nov 30, 2013

Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood.Dec 31, 2004

Prenatal paracetamol exposure and risk of wheeze at preschool age.Nov 30, 2011

Prenatal paracetamol exposure is associated with shorter anogenital distance in male infants.Oct 31, 2016

Prepregnancy acetaminophen use may be associated with higher risk of adverse birth outcomes.Dec 17, 2019

Role of combined prenatal and postnatal paracetamol exposure on asthma development: the Czech ELSPAC study.Mar 31, 2018

Short-term administration of low-dose aspirin is associated with small bowel injuries and blood flow.Jan 14, 2011

The relationship of prenatal acetaminophen exposure and attention-related behavior in early childhood.Dec 31, 2023

This study suggests that use of acetaminophen in middle to late but not early pregnancy may be related to respiratory symptoms in the first year of life.Aug 31, 2008

This suggests that acetaminophen may not be as safe in pregnancy as is widely believed.Feb 29, 2016

Tylenol use has been linked to unexplained dyspepsia.Jun 01, 1988

Under hypoxic conditions, the presence of aspirin would not help to inhibit further platelet activation.May 01, 1999

Use of non-selective NSAIDs was associated with an increased early risk of out-of-hospital cardiac arrest.Dec 25, 2016

Vitamin C attenuates aspirin-induced gastric damage. May 01, 2009

Yogurt containing Lactobacillus gasseri mitigates aspirin-induced small bowel injuries.Dec 31, 2016

Acetaminophen reduces glutathione in human tissues which is necessary to detoxify residual formaldehyde present in childhood vaccines.Aug 01, 2005

Acetaminophen toxicity induces mitochondrial complex I inhibition in human liver tissue.Aug 11, 2019

The results of this in vitro study suggested that high doses of acetaminophen may cause serious damage towards human mesenchymal stem cells.Jun 18, 2015

This study highlights the potential for acetaminophen to interfere with hormone regulation during pregnancy.Jan 05, 2021

NSAID-induced toxicity

View the Evidence:
567 Abstracts with NSAID-induced toxicity Research