NSAID-induced toxicity

Name	AC	CK
Vitamin C	5	28
Ginsenosides	12	23
Flavonoids	10	21
Curcumin	11	20
Dandelion	8	16
NAC (N-acetyl-L-cysteine)	9	16
Sulforaphane	5	14
Banana	4	12
Nigella sativa (aka Black Seed)	6	12
Vitamin E	4	12
Enterococcus faecium	1	10
Lactobacillus gasseri	1	10
Lactobacillus rhamnosus	1	10
Yoghurt	1	10
Fucoidan	5	9
Berberine	4	8
Cinnamon	4	8
Fisetin	4	8
Palm Tree	2	8
Silymarin	4	8
Apigenin	3	6
Astaxanthin	3	6
Cardamom	2	6
Chrysin	3	6
Hydrogen Water	3	6
Mululuza	3	6
Pomegranate	2	6
Pterostilbene	3	6
Tanshinone IIA	4	6
Thymoquinone	3	6
Burdock	3	5
Citrus naringin	3	5
Lemon	3	5
Licorice	3	5
Resveratrol	3	5
Allicin	2	4
Alpha-Lipoic Acid	2	4
Artichoke	2	4
Astragaloside	2	4
Baccharis trimera	2	4
Basil	2	4
EGCG (Epigallocatechin gallate)	2	4
Echinacea	2	4
Frankincense	2	4
Fructose	1	4
Ginkgo biloba	2	4
Glucose	1	4
Grape Seed Extract	2	4
Honey	1	4
Honokiol	2	4
Lycopene	2	4
Maltose	1	4
Moringa oleifera	2	4
Mulberry	2	4
Mussel: Green-lipped (Perna canaliculus)	1	4
Paeoniflorin	2	4
Panax Ginseng	2	4
Passion Flower	2	4
Polyphenols	2	4
Poria cocos	2	4
Prickly Pear Cactus	2	4
Quercetin	2	4
Rosemary	2	4
Rosmarinic acid	2	4
Schisandra	2	4
Selenium	2	4
Silibinin	2	4
Sinomenine	2	4
Spirulina	2	4
Sucrose	1	4
White Clover	2	4
Zataria multiflora	2	4
Carvacrol	2	3
Diallyl sulfide	2	3
Ferulic acid	1	3
Goji	2	3
Honeysuckle	2	3
Naringenin	2	3
Rose	2	3
Saffron	2	3
Salvia miltiorrhiza	1	3
Shikonin	2	3
Thymol	2	3
Turmeric	2	3
6-Shogaol	1	2
Acacia catechu	1	2
Achiote	1	2
Aloe Vera	1	2
Amygdalin	1	2
Andrographis	1	2
Andrographolide	1	2
Anthocyanins	1	2
Apple Polyphenols	1	2
Apples	1	2
Artesunate	1	2
Bael	1	2
Bamboo	1	2
Bee Propolis	1	2
Bergamot	1	2
Beta-glucan	1	2
Betanin	1	2
Bitter Apple	1	2
Bixin	1	2
Black Tea	1	2
Broccoli Sprouts	1	2
Butterfly Pea	1	2
Carbon 60	1	2
Carnosic Acid	1	2
Carnosine	1	2
Carotenoids	1	2
Catechols	1	2
Celery	1	2
Chamomile	1	2
Chives	1	2
Chlorella (Algae)	1	2
Citrus Triterpenoids	1	2
Coconut Water	1	2
Coenzyme Q10	1	2
Corn Silk	1	2
Cumin	1	2
D-Limonene	1	2
Date Seeds	1	2
Emodin	1	2
Eriodictyol	1	2
Garden Cress (Lepidium sativum)	1	2
Garlic	1	2
Gastrodin	1	2
Genistein	1	2
Geranium	1	2
Germanium	1	2
Ginger	1	2
Gingerol	1	2
Ginseng (American)	1	2
Glycyrrhizin	1	2
Gold (nanoparticles)	1	2
Goldenseal	1	2
Gotu Kola	1	2
Guava	1	2
Hesperidin	1	2
Histidine	1	2
Horse Chestnut	1	2
Isoflavones	1	2
Jujube	1	2
Juniper	1	2
Kombucha Tea	1	2
Lactobacillus casei	1	2
Lignans	1	2
Liquiritigenin	1	2
Loquat	1	2
Loquat Seeds	1	2
Luteolin	1	2
MSM (Methylsulfonylmethane)	1	2
Mangiferin	1	2
Mango	1	2
Melatonin	1	2
Methionine	1	2
Milk Thistle	1	2
Nicotinamide	1	2
Nobiletin	1	2
Nutmeg	1	2
Olive Oil	1	2
Omega-3 Fatty Acids	1	2
Organosulfur Compounds	1	2
P-Coumaric Acid	1	2
Paeonol	1	2
Panax Notoginseng	1	2
Papaya	1	2
Parsley	1	2
Peony	1	2
Phellinus Linteus	1	2
Phosphatidylcholine	1	2
Phyllanthus urinaria	1	2
Piperine	1	2
Plantago major	1	2
Pomegranate Peel	1	2
Probiotics	1	2
Propolis: Brazillian	1	2
Prunella vulgaris	1	2
Pumpkin Seed Oil/Meal	1	2
Pycnogenol (Pine Bark)	1	2
Rosemaric Acid	1	2
Safflower	1	2
Sage	1	2
Satsuma	1	2
Seaweed	1	2
Sembung Leaf	1	2
Sesamol	1	2
Shiitake Mushroom	1	2
Silver (nanoparticles)	1	2
St. Johns Wort	1	2
Tea	1	2
Terminalia chebula	1	2
Thyme	1	2
Tocotrienols	1	2
Tongkat Ali	1	2
Toona sinensis	1	2
Tribulus	1	2
Urolithin A	1	2
Vitamin B-12	1	2
Vitamin D	1	2
Water: Deep Sea	1	2
Watercress	1	2
Wheat Grass	1	2
Wogonin	1	2
Woodfordia fruticosa	1	2
Xanthohumol	1	2
Yellow Sweet Clover (Melilotus officinalis)	1	2
Zerumbone	1	2
Zucchini	1	2
Cannabinoids	1	1
Citrus Peel	1	1
Curcuminoids	1	1
Ginseng	1	1
Ginseng (Korean)	1	1
Kaempferol	1	1
Lactobacillus fermentum	1	1
Lotus	1	1
Purslane	1	1
Reishi Mushroom	1	1
Tangeretin	1	1
Tetrahydrocurcumin	1	1
Tryptophan	1	1

Name	AC	CK
Acetaminophen	303	731
Paracetamol	268	634
Aspirin	38	152
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	12	75
Tylenol	9	57
Diclofenac	5	34
Ibuprofen	4	26
Analgesic: Non-opioid	2	12
Celecoxib	1	10
Diphenhydramine	1	10
Naproxen	1	10
Rofecoxib	1	10
Indomethacin	3	8
Endocrine Disruptors	2	7
Antibiotics	2	2
Atorvastatin	1	2
High Fructose Corn Syrup	1	2
Plutonium 238	1	2
Statin Drugs	1	2
Uranium	1	2
Allopurinol	1	1
Cadmium	1	1
Cisplatin	1	1
Doxorubicin	1	1
Gentamicin	1	1
Glyphosate	1	1
Lead	1	1
Pesticides	1	1

Name	AC	CK
Acupuncture	1	10
Hyperbaric Treatment	1	2
Ozone Therapy	1	2
Photobiomodulation	1	2

Name	AC	CK	Focus
Vaccination: All	2	7

[+]

Prevalence of hypersensitivity reactions in children associated with acetaminophen.Dec 31, 2017

Click here to read the entire abstract

Pubmed Data : Int Arch Allergy Immunol. 2018 ;176(2):106-114. Epub 2018 Apr 3. PMID: 29614487

Article Published Date : Dec 31, 2017

Study Type : Meta Analysis, Review

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Hypersensitivity

Problem Substances : Acetaminophen, Paracetamol

[+]

This analysis suggests Helicobacter pylori increases the risk of low-dose aspirin ulcers.Nov 07, 2018

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Pubmed Data : J Gastroenterol Hepatol. 2018 Nov 8. Epub 2018 Nov 8. PMID: 30408229

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Autism Open Access. 2016 Apr ;6(2). Epub 2016 Mar 28. PMID: 27695658

Article Published Date : Mar 31, 2016

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Autism Spectrum Disorders

Additional Keywords : Endocannabinoid System

Problem Substances : Acetaminophen, Paracetamol

[+]

Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers.Nov 30, 1990

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Pubmed Data : J Infect Dis. 1990 Dec ;162(6):1277-82. PMID: 2172402

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Pubmed Data : Am J Emerg Med. 2015 Jun ;33(6):749-53. Epub 2015 Feb 25. PMID: 25827597

Click here to read the entire abstract

Pubmed Data : Scand J Gastroenterol. 2022 May 9:1-7. Epub 2022 May 9. PMID: 35534443

Article Published Date : May 08, 2022

Study Type : Human Study

Additional Links

Substances : Enterococcus faecium, Lactobacillus rhamnosus

Diseases : Aspirin-Induced Toxicity

Pharmacological Actions : Gastroprotective

Problem Substances : Aspirin

[+]

Maternal acetaminophen biomarkers were specifically associated with increased risk of ADHD diagnosis in offspring. Jul 02, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Eur Heart J Cardiovasc Pharmacother. 2016 Dec 26. Epub 2016 Dec 26. PMID: 28025218

Click here to read the entire abstract

Pubmed Data : Int J Biochem Cell Biol. 2005 Aug ;37(8):1727-37. Epub 2005 Apr 26. PMID: 15878691

Article Published Date : Aug 01, 2005

Study Type : Human In Vitro

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Enzyme Inhibitors

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Acetaminophen

[+]

Acetaminophen toxicity induces mitochondrial complex I inhibition in human liver tissue.Aug 11, 2019

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Pubmed Data : Basic Clin Pharmacol Toxicol. 2019 Aug 12. Epub 2019 Aug 12. PMID: 31403256

Article Published Date : Aug 11, 2019

Study Type : Animal Study, Human In Vitro

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Problem Substances : Acetaminophen

[+]

The results of this in vitro study suggested that high doses of acetaminophen may cause serious damage towards human mesenchymal stem cells.Jun 18, 2015

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Pubmed Data : Int J Mol Med. 2015 Jun 19. Epub 2015 Jun 19. PMID: 26096646

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Pubmed Data : Cureus. 2019 Nov 27 ;11(11):e6251. Epub 2019 Nov 27. PMID: 31890447

Article Published Date : Nov 26, 2019

Study Type : Human: Case Report

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Protection of taraxasterol against acetaminophen-induced liver injury.Jul 24, 2023

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Pubmed Data : Phytomedicine. 2023 Jul 25 ;116:154872. Epub 2023 May 13. PMID: 37209606

Article Published Date : Jul 24, 2023

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Dandelion

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen

[+]

Rosemary extract protects liver mitochondria from oxidative damage and prevents acetaminophen-induced hepatotoxicity.Mar 02, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antioxidants (Basel). 2023 Mar 3 ;12(3). Epub 2023 Mar 3. PMID: 36978874

Article Published Date : Mar 02, 2023

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Rosemary

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen

[+]

Salvianolic acid A protects against acetaminophen-induced hepatotoxicity.Apr 02, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antioxidants (Basel). 2023 Apr 3 ;12(4). Epub 2023 Apr 3. PMID: 37107244

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Pubmed Data : J Ayub Med Coll Abbottabad. 2020 Jan- Mar;32(1):28-32. PMID: 32468750

A natural flavonoid present in unripe plantain banana pulp (Musa sapientum L. var. paradisiaca) protects the gastric mucosa from aspirin-induced erosions.Jun 01, 1999

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Pubmed Data : J Ethnopharmacol. 1999 Jun;65(3):283-8. PMID: 10404428

Article Published Date : Jun 01, 1999

Study Type : Animal Study

Additional Links

Substances : Banana, Flavonoids

Diseases : Aspirin-Induced Toxicity , NSAID-induced toxicity

Pharmacological Actions : Anti-Ulcer Agents

[+]

A. catechu seed extract is a promising agent for protecting liver from acetaminophen induced hepatotoxicity.Nov 30, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2018 Dec ;108:838-844. Epub 2018 Sep 24. PMID: 30372895

Article Published Date : Nov 30, 2018

Study Type : Animal Study

Additional Links

Substances : Acacia catechu

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Superoxide Dismutase Up-regulation

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

A. lappa could protect the liver cells from carbon tetrachloride or acetaminophen-induced liver damages.Dec 31, 1999

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Pubmed Data : Am J Chin Med. 2000 ;28(2):163-73. PMID: 10999435

Article Published Date : Dec 31, 1999

Study Type : Animal Study

Additional Links

Substances : Burdock

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Acetaminophen (Tylenol) includes the toxicity associated with chronic exposure to depleted uranium. Jan 05, 2007

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Pubmed Data : Toxicology. 2007 Jan 5;229(1-2):62-72. Epub 2006 Oct 17. PMID: 17126469

Article Published Date : Jan 05, 2007

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Uranium Poisoning

Additional Keywords : Toxic Substance Synergy

Problem Substances : Tylenol, Uranium

Adverse Pharmacological Actions : Hepatotoxic, Nephrotoxic

[+]

Problem Substances : Acetaminophen

[+]

Alpha lipoic acid protects against acetaminophen-induced liver and kidney damage. Jan 20, 2008

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Pubmed Data : Toxicology. 2008 Jan 20;243(3):261-70. Epub 2007 Oct 23. PMID: 18068886

Article Published Date : Jan 20, 2008

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Acetaminophen (Tylenol) Toxicity

[+]

Ameliorative effects of berberine and selenium against paracetamol-induced hepatic toxicity in rats.Dec 31, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Open Vet J. 2024 Jan ;14(1):292-303. Epub 2024 Jan 31. PMID: 38633147

Article Published Date : Dec 31, 2023

Study Type : Animal Study

Additional Links

Substances : Berberine, Selenium

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen

[+]

Ameliorative effects of corn silk extract on acetaminophen-induced renal toxicity.Dec 31, 2020

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Pubmed Data : Environ Sci Pollut Res Int. 2021 Jan ;28(2):1762-1774. Epub 2020 Aug 27. PMID: 32856245

Article Published Date : Dec 31, 2020

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Pubmed Data : J Food Drug Anal. 2017 Oct ;25(4):862-871. Epub 2016 Nov 5. PMID: 28987363

Article Published Date : Sep 30, 2017

Study Type : Animal Study

Additional Links

Substances : Mulberry

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents

Problem Substances : Acetaminophen, Paracetamol

[+]

An isoflavonoid from seeds of Lepidium sativum L. has a protective effect on hepatotoxicity induced by paracetamol.Dec 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2014 ;19(10):15440-51. Epub 2014 Sep 26. PMID: 25264831

Article Published Date : Dec 31, 2013

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Pubmed Data : Front Pharmacol. 2020 ;11:549057. Epub 2020 Nov 20. PMID: 33658919

Article Published Date : Dec 31, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Apigenin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Apigenin prevents acetaminophen-induced liver injury by activating the SIRT1 pathway.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Bixin loaded solid lipid nanoparticles for enhanced hepatoprotection--preparation, characterisation and in vivo evaluation.Sep 30, 2014

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Pubmed Data : Int J Pharm. 2014 Oct 1 ;473(1-2):485-92. Epub 2014 Jul 24. PMID: 25066077

Article Published Date : Sep 30, 2014

Study Type : Animal Study

Additional Links

Substances : Bixin

Diseases : Acetaminophen (Tylenol) Toxicity , Lipid Peroxidation, Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Black ginseng has ameliorative effects against acetaminophen induced hepatotoxicity.Apr 20, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Drug Chem Toxicol. 2022 Mar ;45(2):633-640. Epub 2020 Apr 5. PMID: 32249599

Article Published Date : Feb 28, 2022

Study Type : Animal Study

Additional Links

Substances : Cinnamon

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Problem Substances : Acetaminophen, Paracetamol

[+]

Co-administration of fresh grape fruit juice and bergamottin prevented paracetamol induced hepatotoxicity.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Toxicol Rep. 2015 ;2:677-684. Epub 2015 May 8. PMID: 28962403

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Bergamot

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Coconut water vinegar ameliorates recovery of acetaminophen induced liver damage in mice.Jun 24, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : BMC Complement Altern Med. 2014 Mar 3 ;14:81. Epub 2014 Mar 3. PMID: 24589018

Article Published Date : Mar 02, 2014

Study Type : Animal Study

Additional Links

Substances : Hydrogen Water

Diseases : Aspirin-Induced Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Gastroprotective

Problem Substances : Aspirin

[+]

Early paracetamol exposure produces major changes in serotonergic and dopaminergic neurotransmission in the prefrontal cortex and striatum.Apr 13, 2017

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Pubmed Data : Behav Brain Res. 2017 Apr 14 ;323:162-171. Epub 2017 Feb 3. PMID: 28163096

Article Published Date : Apr 13, 2017

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Additional Keywords : Acetaminophen, Acetaminophen (Tylenol) Toxicity, paracetamol, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Echinacoside alleviates acetaminophen-induced liver injury.Dec 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Anim. 2023 Nov 9 ;72(4):513-519. Epub 2023 Jun 19. PMID: 37331803

Article Published Date : Nov 08, 2023

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Aspirin-Induced Toxicity

Pharmacological Actions : Antioxidants, Gastrointestinal Agents, Gastroprotective

Additional Keywords : Superiority of Natural Substances versus Drugs

Problem Substances : Aspirin

[+]

Emodin attenuates acetaminophen-induced hepatotoxicity via the cGAS-STING pathway.Aug 17, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Inflammation. 2021 Aug 18. Epub 2021 Aug 18. PMID: 34409550

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Pubmed Data : Arch Toxicol. 2019 Apr 24. Epub 2019 Apr 24. PMID: 31020376

Article Published Date : Apr 23, 2019

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Problem Substances : Acetaminophen, Paracetamol

[+]

Extra virgin olive oil protects the testis and blood from the toxicity of paracetamol.Oct 13, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biology (Basel). 2021 Oct 14 ;10(10). Epub 2021 Oct 14. PMID: 34681141

Article Published Date : Oct 13, 2021

Study Type : Animal Study

Additional Links

Substances : Olive Oil

Diseases : Acetaminophen (Tylenol) Toxicity , Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Antioxidants

Problem Substances : Acetaminophen, Paracetamol

[+]

Extract of Triticum aestivum sprouts suppresses acetaminophen-induced hepatotoxicity in mice.Oct 19, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2021 Oct 20 ;26(21). Epub 2021 Oct 20. PMID: 34770745

Article Published Date : Oct 19, 2021

Study Type : Animal Study

Additional Links

Substances : Wheat Grass

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Extracts of J. communis leaves was found to be potent antioxidant and hepatoprotective without any cytotoxicity.Dec 31, 2016

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Fucoidan alleviates acetaminophen-induced hepatotoxicity.Dec 13, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2018 Dec 14 ;19(12). Epub 2018 Dec 14. PMID: 30558169

Article Published Date : Dec 13, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Fucoidan

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen

[+]

Fucoidan exhibits a gastro-protective effect against aspirin-induced ulceration in rats.Jan 31, 2011

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Pubmed Data : Int Immunopharmacol. 2011 Feb ;11(2):157-63. Epub 2010 Nov 26. PMID: 21084063

Article Published Date : Jan 31, 2011

[+]

Ginsenoside Rg1 prevents acetaminophen-induced oxidative stress and apoptosis.Jan 03, 2019

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Pubmed Data : J Asian Nat Prod Res. 2019 Jan 4:1-16. Epub 2019 Jan 4. PMID: 30608002

Article Published Date : Jan 03, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenoside Rg1 protects against acetaminophen-induced liver injury.Jul 16, 2018

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Pubmed Data : Regul Toxicol Pharmacol. 2018 Jul 17 ;98:58-68. Epub 2018 Jul 17. PMID: 30030101

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Pubmed Data : J Agric Food Chem. 2017 Oct 25 ;65(42):9226-9236. Epub 2017 Oct 16. PMID: 28965396

Article Published Date : Oct 24, 2017

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Hepatoprotective, Malondialdehyde Down-regulation

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenoside Rk1 ameliorates paracetamol-induced hepatotoxicity.Dec 31, 2018

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Pubmed Data : Arch Biochem Biophys. 1999 Sep 1;369(1):42-58. PMID: 10462439

Article Published Date : Sep 01, 1999

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Apoptotic, Antioxidants

Additional Keywords : Proanthocyanidins

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Grape seeds extract provided biochemical and histo-pathological improvement in paracetamol induced renal cortical toxicity. Dec 31, 2016

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Pubmed Data : Bratisl Lek Listy. 2017 ;118(4):233-242. PMID: 28471235

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Pubmed Data : Medicina (Kaunas). 2019 May 21 ;55(5). Epub 2019 May 21. PMID: 31117289

Article Published Date : May 20, 2019

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid, Silibinin, Vitamin C

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidant, Hepatoprotective

Additional Keywords : Natural Substance Synergy

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective activity and nephroprotective activity of peel extract from three varieties of the passion fruit.Feb 27, 2019

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Pubmed Data : J Med Food. 2006 ;9(4):524-30. PMID: 17201640

Article Published Date : Dec 31, 2005

Study Type : Animal Study

Additional Links

Substances : Mululuza

Diseases : Acetaminophen (Tylenol) Toxicity , Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Baganda Traditional Medicine, Phytotherapy, Plant Extracts

Problem Substances : Acetaminophen

[+]

Hepatoprotective and antioxidant activity of watercress extract on acetaminophen-induced hepatotoxicity.Jun 30, 2019

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Pubmed Data : Malays J Med Sci. 2018 Mar ;25(2):64-71. Epub 2018 Apr 27. PMID: 30918456

Article Published Date : Feb 28, 2018

Study Type : Animal Study

Additional Links

Substances : Zerumbone

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective potential of Clitoria ternatea leaf extract against paracetamol induced damage in mice.Dec 05, 2011

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Pubmed Data : Molecules. 2011 Dec 6 ;16(12):10134-45. Epub 2011 Dec 6. PMID: 22146374

Article Published Date : Dec 05, 2011

Study Type : Animal Study

Additional Links

Substances : Butterfly Pea, Flavonoids

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective property of oral silymarin is comparable to N-Acetyl cysteine in acetaminophen poisoning. Sep 30, 2012

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Pubmed Data : Gastroenterology Res. 2012 Oct ;5(5):190-194. Epub 2012 Sep 20. PMID: 27785204

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Pubmed Data : Phytother Res. 2015 Jul ;29(7):1097-101. Epub 2015 Apr 8. PMID: 25851311

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Pubmed Data : Mol Biol Rep. 2020 Jan 25. Epub 2020 Jan 25. PMID: 31983015

Article Published Date : Jan 24, 2020

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Pubmed Data : Life Sci. 2016 May 1 ;152:180-9. Epub 2016 Apr 3. PMID: 27049115

Article Published Date : Apr 30, 2016

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Kaempferol sophoroside glucoside mitigates acetaminophen-induced hepatotoxicity.May 29, 2024

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Pubmed Data : Heliyon. 2024 May 30 ;10(10):e31448. Epub 2024 May 17. PMID: 38813141

Article Published Date : May 29, 2024

Study Type : Animal Study

Additional Links

Substances : Kaempferol

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-10 upregulation, NF-kappaB Inhibitor

Problem Substances : Acetaminophen

[+]

Lactobacillus casei protects against aspirin-induced small bowel injury. May 10, 2011

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Pubmed Data : J Gastroenterol. 2011 May 10. Epub 2011 May 10. PMID: 21556830

Article Published Date : May 10, 2011

Study Type : Animal Study

Additional Links

Substances : Lactobacillus casei

Diseases : Aspirin-Induced Toxicity

[+]

Licochalcone A upregulates Nrf2 antioxidant pathway and thereby alleviates acetaminophen-induced hepatotoxicity.Dec 31, 2017

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Pubmed Data : Bioorg Med Chem. 2017 Feb 1 ;25(3):1057-1065. Epub 2016 Dec 18. PMID: 28031152

Article Published Date : Jan 31, 2017

Study Type : Animal Study

Additional Links

Substances : Lycopene

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Matrix metalloproteinase-2 (MMP-2) inhibitor

Additional Keywords : Acetaminophen (Tylenol) Toxicity, Anti-Inflammatory Agents, Hepatoprotective, Liver Damage: Drug-Induced, lycopene

Problem Substances : Acetaminophen, Paracetamol

[+]

Mangiferin ameliorates acetaminophen-induced hepatotoxicity.Jun 14, 2019

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Pubmed Data : Biomed Pharmacother. 2019 Jun 15 ;117:109097. Epub 2019 Jun 15. PMID: 31212128

Article Published Date : Jun 14, 2019

Study Type : Animal Study

Additional Links

Substances : Mangiferin

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Melatonin prevents acetaminophen-induced kidney injury in rats. Jan 01, 2009

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Pubmed Data : Int Urol Nephrol. 2009;41(3):695-702. Epub 2009 Jan 1. PMID: 19117117

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Acetaminophen (Tylenol) Toxicity

[+]

Melilotus officinali has strong hepatoprotective activity against paracetamol and carbon tetrachloride induced hepatotoxicity.Apr 30, 2017

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Pubmed Data : Acta Pol Pharm. 2017 May ;74(3):903-909. PMID: 29513960

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Pubmed Data : PeerJ. 2016 ;4:e2127. Epub 2016 Jul 7. PMID: 27441110

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Moringa oleifera

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Moringa oleifera prevents acetaminophen induced liver injury through restoration of glutathione level. Aug 01, 2008

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Pubmed Data : Food Chem Toxicol. 2008 Aug;46(8):2611-5. Epub 2008 Apr 25. PMID: 18514995

Article Published Date : Aug 01, 2008

Study Type : Animal Study

Additional Links

Substances : Moringa oleifera

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Glutathione Upregulation

[+]

Myristica fragrans kernels prevent paracetamol-induced hepatotoxicity.Feb 24, 2019

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Pubmed Data : Int J Mol Sci. 2019 Feb 25 ;20(4). Epub 2019 Feb 25. PMID: 30823534

Article Published Date : Feb 24, 2019

Study Type : Animal Study

Additional Links

Substances : Nutmeg

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

N-acetylcysteine and glycyrrhizin combination: Benefit outcome in a murine model of acetaminophen-induced liver failure.Sep 26, 2020

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Pubmed Data : Food Funct. 2022 Sep 2. Epub 2022 Sep 2. PMID: 36052647

Article Published Date : Sep 01, 2022

Study Type : Animal Study

Additional Links

Substances : Pterostilbene

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Opuntia extracts are hepatoprotective and can be used as a nutraceutical to prevent acute liver failure.Oct 03, 2016

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Pubmed Data : Nutrients. 2016 Oct 4 ;8(10). Epub 2016 Oct 4. PMID: 27782042

Article Published Date : Oct 03, 2016

Study Type : Animal Study

Additional Links

Substances : Prickly Pear Cactus

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Oral administration of rosmarinic acid dose-dependently elicited significant hepatoprotective effects.Nov 30, 2017

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Pubmed Data : Pharm Biol. 2017 Dec ;55(1):1809-1816. PMID: 28545313

Article Published Date : Nov 30, 2017

Study Type : Animal Study

Additional Links

Substances : Rosemaric Acid

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective

[+]

Click here to read the entire abstract

Pubmed Data : Molecules. 2022 Dec 4 ;27(23). Epub 2022 Dec 4. PMID: 36500627

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Pharmacol Rep. 2016 Dec ;68(6):1159-1164. Epub 2016 Sep 7. PMID: 27611980

Article Published Date : Nov 30, 2016

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Additional Keywords : Acetaminophen, Acetaminophen (Tylenol) Toxicity, paracetamol, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

Adverse Pharmacological Actions : Neurotoxic

[+]

Prenatal exposure to acetaminophen may impair male sexual behaviour in adulthood by disrupting the sexual neurobehavioral programming.Jul 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2022 May 31 ;68(5):24-33. Epub 2022 May 31. PMID: 36029509

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Pubmed Data : Iran J Kidney Dis. 2022 Mar ;16(2):108-114. PMID: 35489079

Article Published Date : Feb 28, 2022

Study Type : Animal Study

Additional Links

Substances : Germanium

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Renoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

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The Following are Sub-Topics of NSAID-induced toxicity

View the Evidence: 418 Abstracts with NSAID-induced toxicity Research

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Prevalence of hypersensitivity reactions in children associated with acetaminophen.Dec 31, 2017

This analysis suggests Helicobacter pylori increases the risk of low-dose aspirin ulcers.Nov 07, 2018

Acetaminophen and diphenhydramine premedication for for allergic and febrile nonhemolytic transfusion reactions may be ineffective and unsafe. Jan 01, 2007

Acetaminophen changes Mu rhythm power related to pain empathy.Jun 05, 2023

Acetaminophen elevates unbound bilirubin levels by the glucose oxidase-peroxidase method.Aug 31, 2021

Acetaminophen use after measles-mumps-rubella vaccination is associated with autistic disorder.May 01, 2008

Acetaminophen use for fever in children associated with autism spectrum disorder.Mar 31, 2016

Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers.Nov 30, 1990

Aspirin use is associated with a higher rate of vitamin B12 deficiency in patients hospitalized with cardiovascular disease.Oct 01, 2004

Association of acetaminophen use during pregnancy with behavioural problems in childhood.Sep 30, 2016

Autism may be associated with the use of acetaminophen in children. Dec 01, 2009

Chronic tylenol use is associated wtih an almost two-fold increased risk of blood cancer.May 09, 2011

Comparison of the efficacy of diclofenac, acupuncture, and acetaminophen in the treatment of renal colic.May 31, 2015

Decline of aspirin use is associated with a decreased incidence of Reye's syndrome.Jun 01, 1987

Drug-induced liver toxicity (particularly acetaminophen-induced liver toxicity) has replaced viral hepatitis as the most single frequent cause of acute liver failutre in ubran Sep 01, 2009

Exposure to paracetamol in utero was associated with increased risks of motor milestone delay and impaired communication skills in children at 18 months.Nov 30, 2016

Harmful effects of NSAIDs among patients with hypertension and coronary artery disease include increased cardiac mortality. Jul 01, 2011

Lactobacillus complex capsules ameliorate aspirin-related small intestinal mucosal injury: a prospective, randomized, controlled clinical trial.May 08, 2022

Maternal acetaminophen biomarkers were specifically associated with increased risk of ADHD diagnosis in offspring. Jul 02, 2018

Maternal acetaminophen use during pregnancy is associated with a higher risk for hyperkinetic disorders and ADHD-like behaviors in children.Mar 31, 2014

Maternal acetaminophen use during pregnancy was associated with lower performance IQ in 5-year olds.Oct 31, 2016

Maternal paracetamol use during pregnancy could be associated with poorer attention and executive function in 5-year-olds.Nov 30, 2016

Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sonsDec 31, 2016

More than half of patients who present at the hospital with acetaminophen-induced liver damage or liver failure have undetectable levels of acetaminophen.Feb 04, 2019

Paracetamol was associated with increased mortality, especially cardiovascular.Jul 31, 2015

Prenatal acetaminophen exposure was associated with a greater number of autism spectrum symptoms in males.Dec 31, 2015

Prenatal paracetamol exposure and child neurodevelopment.Nov 30, 2013

Prepregnancy acetaminophen use may be associated with higher risk of adverse birth outcomes.Dec 17, 2019

Short-term administration of low-dose aspirin is associated with small bowel injuries and blood flow.Jan 14, 2011

This suggests that acetaminophen may not be as safe in pregnancy as is widely believed.Feb 29, 2016

Tylenol use has been linked to unexplained dyspepsia.Jun 01, 1988

Under hypoxic conditions, the presence of aspirin would not help to inhibit further platelet activation.May 01, 1999

Use of non-selective NSAIDs was associated with an increased early risk of out-of-hospital cardiac arrest.Dec 25, 2016

Vitamin C attenuates aspirin-induced gastric damage. May 01, 2009

Yogurt containing Lactobacillus gasseri mitigates aspirin-induced small bowel injuries.Dec 31, 2016

Acetaminophen reduces glutathione in human tissues which is necessary to detoxify residual formaldehyde present in childhood vaccines.Aug 01, 2005

Acetaminophen toxicity induces mitochondrial complex I inhibition in human liver tissue.Aug 11, 2019

The results of this in vitro study suggested that high doses of acetaminophen may cause serious damage towards human mesenchymal stem cells.Jun 18, 2015

This study highlights the potential for acetaminophen to interfere with hormone regulation during pregnancy.Jan 05, 2021

Farrerol ameliorates acetaminophen-induced hepatotoxicity.Dec 31, 2018

Ferulic acid ameliorates acetaminophen-induced acute liver injury.May 04, 2022

Novel use of N-acetylcysteine in management of tyrosine kinase inhibitor induced acute liver injury.Nov 26, 2019

Protection of taraxasterol against acetaminophen-induced liver injury.Jul 24, 2023

Rosemary extract protects liver mitochondria from oxidative damage and prevents acetaminophen-induced hepatotoxicity.Mar 02, 2023

Salvianolic acid A protects against acetaminophen-induced hepatotoxicity.Apr 02, 2023

Anti-inflammatory and antioxidant effects of Apium graveolens L. extracts mitigate against fatal acetaminophen-induced acute liver toxicity.Jul 25, 2020

Co-administration of N-Acetylcysteine and Acetaminophen efficiently blocks Acetaminophen toxicity.Jul 31, 2015

Pterostilbene-loaded soluplus/poloxamer 188 mixed micelles for protection against acetaminophen-induced acute liver injury.Feb 05, 2023

Sasa veitchii extracts suppress acetaminophen-induced hepatotoxicity in mice Jun 11, 2017

The hepatoprotective effect of prazosin is comparable to N- acetylcysteine against acetaminophen induced hepatotoxicity.Feb 29, 2020

"Aspirin's ability to induce intestinal injury in rats is dependent on bile and can be reversed if pre-associated with phosphatidylcholine."Aug 01, 2011

"ulforaphane Protects Small Intestinal Mucosa From Aspirin/NSAID-Induced Injury by Enhancing Host Defense Systems Against Oxidative Stress and by Inhibiting Mucosal Invasion of Anaerobic Enterobacteria."Aug 22, 2012

6-gingerol, an active ingredient of ginger, protects acetaminophen-induced liver damage in mice.Nov 01, 2011

A combination of resveratrol and quercetin suppressed glomerular damage and apoptosis induced by acetaminophen in the kidney.Feb 02, 2020

A combination strategy of thymoquinone and curcumin might be considered as a potential antidote in combating liver injury induced by acetaminophen.Mar 04, 2019

A crude aqueous leafy extract of M. indica possesses hepatoprotective effects.Jun 30, 2022

A methanolic extract of pomegranate peel ameliorated the hepatic damage caused by acetaminophen.Jun 30, 2016

A natural flavonoid present in unripe plantain banana pulp (Musa sapientum L. var. paradisiaca) protects the gastric mucosa from aspirin-induced erosions.Jun 01, 1999

A. catechu seed extract is a promising agent for protecting liver from acetaminophen induced hepatotoxicity.Nov 30, 2018

A. lappa could protect the liver cells from carbon tetrachloride or acetaminophen-induced liver damages.Dec 31, 1999

Acetaminophen (Tylenol) includes the toxicity associated with chronic exposure to depleted uranium. Jan 05, 2007

Acetaminophen affects empathy-like behavior in rats.Nov 30, 2018

Acetaminophen could cause transient mitochondrial dysfunction that may synergize with other stresses to promote liver damage and steatosis.Dec 30, 2015

Acetaminophen-induced liver injury: Molecular mechanism and treatments from natural products.Dec 31, 2022

Allicin and omega-3 fatty acids attenuates acetaminophen mediated renal toxicity.Jul 11, 2023

Alpha lipoic acid protects against acetaminophen-induced liver and kidney damage. Jan 20, 2008

Ameliorative effects of berberine and selenium against paracetamol-induced hepatic toxicity in rats.Dec 31, 2023

Ameliorative effects of corn silk extract on acetaminophen-induced renal toxicity.Dec 31, 2020

Amygdalin protects against acetaminophen-induced acute liver failure.Apr 29, 2022

An aqueous extract of white clover was protective against the hepatotoxicity induced by acetaminophen.Aug 31, 2019

An extract from Mulberry leaf decelerates acetaminophen induced hepatic inflammation.Sep 30, 2017

An isoflavonoid from seeds of Lepidium sativum L. has a protective effect on hepatotoxicity induced by paracetamol.Dec 31, 2013

NSAID-induced toxicity

View the Evidence:
418 Abstracts with NSAID-induced toxicity Research