Oral Submucous Fibrosis

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17 Substances Researched for Oral Submucous Fibrosis
NameACCKFocus
Curcumin965Locked
Aloe Vera532Locked
Turmeric330Locked
Astaxanthin110Locked
Holy Basil110Locked
Lycopene110Locked
Triphala110Locked
Turmeric: Volatile Oils110Locked
Thymoquinone12Locked
Capsaicin11Locked
Honokiol11Locked
Isoflavones11Locked
Mangiferin11Locked
Spirulina11Locked
Vitamin A11Locked
Vitamin C11Locked
Vitamin E11Locked
2 Therapeutic Actions Researched for Oral Submucous Fibrosis
NameACCKFocus
Photobiomodulation212Locked
Integrative Medicine110Locked

View the Evidence:
26 Abstracts with Oral Submucous Fibrosis Research

[+]

Comparing efficacy of curcumin with other treatment modalities in oral submucous fibrosis management.Dec 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ayurveda Integr Med. 2024 ;15(4):100950. Epub 2024 Jul 9. PMID: 38986267
Article Published Date : Dec 31, 2023
Study Type : Meta Analysis, Review
Additional Links
Substances : Curcumin
Diseases : Oral Submucous Fibrosis
Pharmacological Actions : Chemopreventive
[+]

Aloe vera can be an alternative, safe, and effective treatment regime in the management of oral submucous fibrosis.Jun 16, 2016

Pubmed Data : J Oral Pathol Med. 2016 Jun 17. Epub 2016 Jun 17. PMID: 27314762
Article Published Date : Jun 16, 2016
Study Type : Human Study
Additional Links
Substances : Aloe Vera
Diseases : Oral Submucous Fibrosis
Additional Keywords : Significant Treatment Outcome
[+]

Astaxanthin may have a positive impact on mouth opening and burning sensation in individuals with oral submucous fibrosis.Jan 31, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cureus. 2024 Feb ;16(2):e54667. Epub 2024 Feb 22. PMID: 38524025
Article Published Date : Jan 31, 2024
Study Type : Human Study
Additional Links
Substances : Astaxanthin
Diseases : Oral Submucous Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Black turmeric and Aloe vera in the management of oral submucous fibrosis.Nov 30, 2021

Pubmed Data : Asian Pac J Cancer Prev. 2021 Dec 1 ;22(12):3941-3947. Epub 2021 Dec 1. PMID: 34967575
Article Published Date : Nov 30, 2021
Study Type : Human Study
Additional Links
Substances : Curcumin, Turmeric
Diseases : Oral Submucous Fibrosis
Pharmacological Actions : Anti-Fibrotic
Additional Keywords : Plant Extracts
[+]

Curcumin and lycopene treatment led to significant improvements in patients suffering from oral submucous fibrosis.Jul 29, 2018

Pubmed Data : Oral Dis. 2018 Jul 30. Epub 2018 Jul 30. PMID: 30059188
Article Published Date : Jul 29, 2018
Study Type : Human Study
Additional Links
Substances : Curcumin, Lycopene
Diseases : Oral Submucous Fibrosis
Additional Keywords : Significant Treatment Outcome
[+]

Curcumin gel and Aloe Vera gel are effective in improving oral submucous fibrosis symptoms.Jan 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2021 Feb 1 ;22(S1):107-112. Epub 2021 Feb 1. PMID: 33576219
Article Published Date : Jan 31, 2021
Study Type : Human Study
Additional Links
Substances : Curcumin
Diseases : Oral Submucous Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Determination of effectiveness of photobiomodulation in the treatment of oral submucous fibrosis.Jun 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharm Bioallied Sci. 2022 Jul ;14(Suppl 1):S475-S478. Epub 2022 Jul 13. PMID: 36110778
Article Published Date : Jun 30, 2022
Study Type : Human Study
Additional Links
Diseases : Oral Submucous Fibrosis
Therapeutic Actions : Photobiomodulation
[+]

Early human safety study of turmeric oil (Curcuma longa oil) administered orally in healthy volunteers.Oct 31, 2003

Pubmed Data : J Assoc Physicians India. 2003 Nov ;51:1055-60. PMID: 15260388
Article Published Date : Oct 31, 2003
Study Type : Human Study
Additional Links
Substances : Turmeric, Turmeric: Volatile Oils
Diseases : Oral Cancer, Oral Submucous Fibrosis
Additional Keywords : Curcumin Safety, Plant Extracts
[+]

Early human safety study of turmeric oil (Curcuma longa oil) administered orally in healthy volunteers.Oct 31, 2003

Pubmed Data : J Assoc Physicians India. 2003 Nov ;51:1055-60. PMID: 15260388
Article Published Date : Oct 31, 2003
Study Type : Human Study
Additional Links
Substances : Curcumin
Diseases : Oral Cancer, Oral Submucous Fibrosis
Additional Keywords : Curcumin Safety, Plant Extracts
[+]

Efficacy of topical tulsi paste for the management of oral submucous fibrosis.Mar 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Indian J Dent Res. 2022 Apr-Jun;33(2):146-151. PMID: 36254950
Article Published Date : Mar 31, 2022
Study Type : Human Study
Additional Links
Substances : Holy Basil
Diseases : Oral Submucous Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants
[+]

Efficiency of turmeric, triphala and aloe vera in the treatment of oral submucous fibrosis.Dec 31, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Bioinformation. 2025 ;21(4):630-634. Epub 2025 Apr 30. PMID: 40636208
Article Published Date : Dec 31, 2024
Study Type : Human Study
Additional Links
Substances : Aloe Vera, Triphala, Turmeric
Diseases : Oral Submucous Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Improvement in all the parameters was seen with the individuals receiving Aloe vera gel in comparison to antioxidants.Dec 31, 2015

Pubmed Data : J Contemp Dent Pract. 2016 ;17(1):78-84. Epub 2016 Jan 1. PMID: 27084867
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Substances : Aloe Vera
Diseases : Oral Submucous Fibrosis
Therapeutic Actions : Integrative Medicine
Pharmacological Actions : Analgesics
[+]

Evaluation of the anti-fibrotic effect of thymoquinone in the management of oral submucous fibrosis.Sep 26, 2025

Pubmed Data : Odontology. 2025 Sep 27. Epub 2025 Sep 27. PMID: 41014439
Article Published Date : Sep 26, 2025
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Oral Submucous Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Photobiomodulation therapy inhibits oral submucous fibrosis.Sep 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oral Dis. 2020 Oct ;26(7):1474-1482. Epub 2020 Jun 3. PMID: 32391600
Article Published Date : Sep 30, 2020
Study Type : Animal Study
Additional Links
Diseases : Oral Submucous Fibrosis
Therapeutic Actions : Photobiomodulation
Pharmacological Actions : Anti-Fibrotic
[+]

Aloe barbadensis can play a significant role in dentistry in treatment of lichen planus, oral submucous fibrosis, recurrent aphthous stomatitis, alveolar osteitis, periodontitis.Mar 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharm Bioallied Sci. 2015 Apr ;7(Suppl 1):S255-9. PMID: 26015726
Article Published Date : Mar 31, 2015
Study Type : Review
Additional Links
Substances : Aloe Vera
Diseases : Gingivitis, Lichen Planus, Oral Submucous Fibrosis, Periodontal Diseases, Radiation Induced Illness: Mucositis, Stomatitis: Aphthous
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Immunomodulatory, Radioprotective
Additional Keywords : Aloe Barbadensis
[+]

Curcumin alleviates arecoline-induced oral submucous fibrosis.Dec 14, 2024

Pubmed Data : Cell Biochem Biophys. 2024 Dec 15. Epub 2024 Dec 15. PMID: 39674970
Article Published Date : Dec 14, 2024
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Oral Submucous Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Curcumin suppresses EMT to alleviate oral submucous fibrosis progression.Oct 29, 2025

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int Dent J. 2025 Oct 30 ;76(1):103975. Epub 2025 Oct 30. PMID: 41172676
Article Published Date : Oct 29, 2025
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Oral Submucous Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Glabridin inhibits the activation of myofibroblasts in human fibrotic buccal mucosal fibroblasts.Jan 31, 2018

Pubmed Data : Environ Toxicol. 2018 Feb ;33(2):248-255. Epub 2017 Nov 9. PMID: 29119715
Article Published Date : Jan 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Isoflavones
Diseases : Oral Submucous Fibrosis
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor
[+]

Honokiol may be a promising compound to alleviate the progression of oral fibrogenesis.May 08, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Formos Med Assoc. 2021 May 9. Epub 2021 May 9. PMID: 33980461
Article Published Date : May 08, 2021
Study Type : In Vitro Study
Additional Links
Substances : Honokiol
Diseases : Oral Cancer, Oral Submucous Fibrosis
Pharmacological Actions : Chemopreventive, Transforming growth factor beta (TGF-β) inhibitor
[+]

Mechanism of curcumin in the prevention and treatment of oral submucosal fibrosis.Oct 24, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BDJ Open. 2024 Oct 25 ;10(1):82. Epub 2024 Oct 25. PMID: 39455570
Article Published Date : Oct 24, 2024
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Oral Submucous Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Mechanism of mangiferin in the treatment of oral submucous fibrosis.Jul 31, 2024

Pubmed Data : Hua Xi Kou Qiang Yi Xue Za Zhi. 2024 Aug 1 ;42(4):444-451. PMID: 39049631
Article Published Date : Jul 31, 2024
Study Type : In Vitro Study
Additional Links
Substances : Mangiferin
Diseases : Oral Submucous Fibrosis
Pharmacological Actions : Anti-Fibrotic
Additional Keywords : Xanthones
[+]

Most studies showed statistically significant result demonstrating the effectiveness of Aloe vera in treatment of oral diseases.Jul 31, 2016

Pubmed Data : J Clin Diagn Res. 2016 Aug ;10(8):ZE01-7. Epub 2016 Aug 1. PMID: 27656587
Article Published Date : Jul 31, 2016
Study Type : Review
Additional Links
Substances : Aloe Vera
Diseases : Burning Mouth Syndrome, Oral Lichen Planus, Oral Mucositis, Oral Submucous Fibrosis, Radiation Induced Illness: Mucositis
[+]

Role of antioxidant vitamins in oral submucous fibrosis.Apr 30, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cureus. 2024 May ;16(5):e59596. Epub 2024 May 3. PMID: 38832153
Article Published Date : Apr 30, 2024
Study Type : Review
Additional Links
Substances : Vitamin A, Vitamin C, Vitamin E
Diseases : Oral Submucous Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants
[+]

The antifibrotic and the anticarcinogenic activity of capsaicin in hot chili pepper in relation to oral submucous fibrosis.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:888280. Epub 2022 May 4. PMID: 35600864
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Capsaicin
Diseases : Oral Submucous Fibrosis
Pharmacological Actions : Angiogenesis Inhibitors, Anti-Fibrotic, Anticarcinogenic Agents, Apoptotic
[+]

This review provides new insight into the potential therapeutic applications of Spirulina.Jul 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Toxicol. 2016 Aug ;90(8):1817-40. Epub 2016 Jun 3. PMID: 27259333
Article Published Date : Jul 31, 2016
Study Type : Review
Additional Links
Substances : Spirulina
Diseases : Allergic Rhinitis, Anemia, Chronic Obstructive Pulmonary Disease, Diabetes Mellitus: Type 2, DNA damage, HIV Infections, Lipid Peroxidation, Oral Submucous Fibrosis, Oxidative Stress, Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Genoprotective, Immunomodulatory
[+]

This reviews the pharmacological action of curcumin and its use in treating oral submucous fibrosis. Sep 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Diagn Res. 2015 Oct ;9(10):ZE01-3. Epub 2015 Oct 1. PMID: 26557633
Article Published Date : Sep 30, 2015
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Oral Cancer: Prevention, Oral Submucous Fibrosis
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

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