Osteosarcoma

Name	AC	CK
Mistletoe	2	20
Berberine	6	11
Flavonoids	10	11
Naringenin	2	11
Bitter Orange	1	10
Melatonin	6	10
Tanshinone IIA	6	9
Formononetin	5	8
Piperine	2	8
Curcumin	7	7
Ginsenosides	7	7
Apigenin	2	6
Horse Chestnut	4	6
EGCG (Epigallocatechin gallate)	4	5
Honokiol	4	5
Organosulfur Compounds	4	5
Resveratrol	4	5
Salvia miltiorrhiza	5	5
Thymoquinone	5	5
Beta-Elemene	3	4
Bufalin	3	4
Cinnamaldehyde	2	4
Diosgenin	4	4
Fisetin	4	4
Fucoidan	4	4
Isoliquiritigenin	3	4
Oridonin	4	4
Shikonin	4	4
Cucurbitacin B	3	3
Garlic	3	3
Genistein	3	3
Huaier (Trametes robiniophila murr)	2	3
Licorice	2	3
Mululuza	1	3
Panax Notoginseng	2	3
Piperlongumine	3	3
Polyphenols	3	3
Punicalagin	3	3
Quercetin	3	3
Sulforaphane	2	3
Ursolic Acid	3	3
Wogonin	3	3
Allicin	2	2
Aloe Vera	2	2
Andrographis	2	2
Ashwagandha	2	2
Asiatic Acid	2	2
Biochanin A	2	2
Bisdemethoxycurcumin	2	2
Black Tea	2	2
Cannabidiol	2	2
Chlorogenic Acid	2	2
Chrysanthemum Indicum	2	2
Cordyceps Militaris	1	2
Cucurbitacin E	1	2
Curcumol	2	2
Delphinidin	2	2
Hesperidin	1	2
Kaempferol	1	2
Lupeol	2	2
Magnolol	2	2
Mangosteen	2	2
Oleanolic acid	2	2
Phenethyl isothiocyanate	2	2
Psychedelics:All	1	2
Reishi Mushroom	2	2
Shiitake Mushroom	2	2
Shilajit	1	2
Sinomenine	1	2
Toona sinensis	1	2
Vitamin C	1	2
Vitamin D	2	2
Alpha Linolenic Acid	1	1
Amygdalin	1	1
Arctigenin	1	1
Artemisinin	1	1
Baicalein	1	1
Bamboo	1	1
Bee Propolis	1	1
Beta-Caryophyllene	1	1
Caffeic acid phenethyl ester	1	1
Carnosol	1	1
Catechin	1	1
Celastrol	1	1
Chaga Mushroom (Inonotus obliquus)	1	1
Chinese Skullcap	1	1
Chrysin	1	1
Citrus naringin	1	1
Deguelin	1	1
Demethoxycurcumin	1	1
EPA (Eicosapentaenoic Acid)	1	1
Elecampane	1	1
Emodin	1	1
False Black Pepper	1	1
Fish Oil	1	1
Germanium	1	1
Ginkgo biloba	1	1
Gold (nanoparticles)	1	1
Hemp Seed	1	1
Indian Mulberry	1	1
Indole-3-Carbinol	1	1
Isoflavones	1	1
Krill	1	1
Lactoferrin	1	1
Lotus	1	1
Luteolin	1	1
Mangiferin	1	1
Mulberry	1	1
Nexrutine (Phellodendrom)	1	1
Nobiletin	1	1
Oleuropein	1	1
Olive	1	1
Onion	1	1
Ox Bile Extract	1	1
Paeoniflorin	1	1
Parthenolide	1	1
Peony	1	1
Phlorotannins	1	1
Phyllanthus urinaria	1	1
Piceatannol	1	1
Plantago	1	1
Plantago asiatica	1	1
Pterostilbene	1	1
Pumpkin Seeds	1	1
Red Sage	1	1
Rhubarb	1	1
Rosemaric Acid	1	1
Safflower	1	1
Saffron	1	1
Saikosaponin	1	1
Seaweed: Brown	1	1
Senna	1	1
Tetrahydrocurcumin	1	1
Tomatidine	1	1
Tualang Honey	1	1
Turmeric	1	1
Venom: Toad	1	1
White Mulberry	1	1
Wormwood	1	1

Name	AC	CK
Simian virus 40 (SV40)	5	19
Forteo	3	14
Dexamethasone	1	3
Sodium Fluoride	1	1
Uranium: Depleted	1	1

Name	AC	CK
Hyperbaric Treatment	1	10
Photobiomodulation	5	5
Photodynamic therapy	3	3
Electroacupuncture	1	2
Infrared Light	1	1
Integrative Medicine	1	1
Light Therapy	1	1

Name	AC	CK	Focus
Radiotherapy	1	10

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After 12 years from the start of the trial, the patients in the Viscum arm continue to show a considerably longer PRDFS compared to oral etoposide.Dec 31, 2019

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Pubmed Data : Mol Med Rep. 2014 Oct ;10(4):1734-8. Epub 2014 Jul 21. PMID: 25050485

Article Published Date : Sep 30, 2014

Study Type : Human In Vitro

Additional Links

Substances : Berberine

Diseases : Osteosarcoma

Pharmacological Actions : Antineoplastic Agents, Apoptotic

[+]

Inhibition of ERK1/2 signalling pathway is involved in melatonin's antiproliferative effect on human MG-63 osteosarcoma cells.Nov 06, 2016

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Pubmed Data : Pan Afr Med J. 2022 ;42:222. Epub 2022 Jul 21. PMID: 36845227

Article Published Date : Dec 31, 2021

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Pubmed Data : J Orthop Surg Res. 2023 Mar 9 ;18(1):180. Epub 2023 Mar 9. PMID: 36895009

Article Published Date : Mar 08, 2023

Study Type : Animal Study, In Vitro Study

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Substances : Piperine

Diseases : Osteosarcoma

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

[+]

A polysaccharide from Trametes robiniophila inhibits human osteosarcoma xenograft tumor growth in vivo.Jun 24, 2015

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Pubmed Data : Carbohydr Polym. 2015 Jun 25 ;124:157-63. Epub 2015 Feb 20. PMID: 25839806

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Pubmed Data : Oncol Rep. 2013 Feb ;29(2):571-8. Epub 2012 Dec 4. PMID: 23232982

Article Published Date : Jan 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Thymoquinone

Diseases : Osteosarcoma

Pharmacological Actions : Anti-Angiogenic, NF-kappaB Inhibitor

[+]

"Genistein inhibits cell invasion and motility by inducing cell differentiation in murine osteosarcoma cell line LM8."Dec 31, 2011

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Pubmed Data : BMC Cell Biol. 2012 ;13(1):24. Epub 2012 Sep 26. PMID: 23013480

Article Published Date : Dec 31, 2011

Study Type : In Vitro Study

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Substances : Genistein

Diseases : Osteosarcoma

Pharmacological Actions : Cell Differentiation Inducer

[+]

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Pubmed Data : Cell Physiol Biochem. 2015 ;36(2):763-72. Epub 2015 May 22. PMID: 26021264

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Nexrutine (Phellodendrom)

Diseases : Cervical Cancer, Colon Cancer, Osteosarcoma

Pharmacological Actions : Antiproliferative , P21 Activation

Additional Keywords : Plant Extracts

[+]

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Pubmed Data : Molecules. 2017 Mar 10 ;22(3). Epub 2017 Mar 10. PMID: 28287444

Article Published Date : Mar 09, 2017

Study Type : In Vitro Study

Additional Links

Substances : Bufalin

Diseases : Osteosarcoma

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation

[+]

Bufalin inhibits cell proliferation and induces mitochondria-dependent apoptosis in osteosarcoma cells.Dec 31, 2015

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Pubmed Data : Oncol Lett. 2018 Aug ;16(2):2143-2150. Epub 2018 Jun 6. PMID: 30008912

Article Published Date : Jul 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Beta-Elemene

Diseases : Bone Cancer

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Cucurbitacin B alone or in combination with methotrexate shows promising antiproliferative activity against human osteosarcoma.Jul 27, 2011

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Pubmed Data : Cancer Lett. 2011 Jul 28 ;306(2):161-70. Epub 2011 Mar 26. PMID: 21440986

Pubmed Data : Environ Toxicol. 2018 Jun ;33(6):640-649. Epub 2018 Feb 16. PMID: 29451351

Article Published Date : May 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Delphinidin

Diseases : Osteosarcoma

Pharmacological Actions : Anti-metastatic, Apoptotic

[+]

Delphinidin may play a critical role as a chemotherapeutic agent by preventing the development and progression of osteosarcoma cells.Dec 27, 2017

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Diosgenin may exhibit utility as an auxiliary treatment for the clinical reduction of metastasis in patients with osteosarcoma.Sep 30, 2019

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Pubmed Data : Oncol Lett. 2019 Mar ;17(3):3305-3313. Epub 2019 Feb 1. PMID: 30867764

Article Published Date : Feb 28, 2019

Study Type : In Vitro Study

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Substances : Celastrol

Diseases : Osteosarcoma

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

[+]

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Pubmed Data : Mol Med Rep. 2018 Feb ;17(2):2719-2723. Epub 2017 Nov 21. PMID: 29207060

Article Published Date : Jan 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Honokiol

Diseases : Osteosarcoma

Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation, Tumor Suppressor Protein p53 Upregulation

[+]

Honokiol suppresses proliferation and induces apoptosis in human osteosarcoma cells.Mar 31, 2018

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Pubmed Data : Int J Mol Med. 2018 Apr ;41(4):1845-1854. Epub 2018 Jan 29. PMID: 29393336

Article Published Date : Mar 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Honokiol

Diseases : Osteosarcoma

Pharmacological Actions : Antiproliferative , Apoptotic, MicroRNA modulator

[+]

Honokiol targets mitochondria to halt cancer progression and metastasis.May 31, 2016

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Pubmed Data : Chemotherapy. 2018 ;63(3):155-161. Epub 2018 Jun 22. PMID: 29936511

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Isoliquiritigenin

Diseases : Osteosarcoma

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation

[+]

Lentinan up-regulates microRNA-340 to promote apoptosis and autophagy of human osteosarcoma cells.Dec 31, 2017

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Pubmed Data : J Pineal Res. 2010 Jan;48(1):72-80. PMID: 20025643

Naringenin induces ROS-mediated ER stress, autophagy, and apoptosis in human osteosarcoma cell lines.Jan 06, 2022

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Pubmed Data : Molecules. 2022 Jan 7 ;27(2). Epub 2022 Jan 7. PMID: 35056691

Article Published Date : Jan 06, 2022

Study Type : In Vitro Study

Additional Links

Substances : Naringenin

Diseases : Osteosarcoma

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

[+]

Naringin targets Zeb1 to suppress osteosarcoma cell proliferation and metastasis.Dec 21, 2018

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Pubmed Data : Antioxidants (Basel). 2021 May 7 ;10(5). Epub 2021 May 7. PMID: 34067035

Article Published Date : May 06, 2021

Study Type : In Vitro Study

Additional Links

Substances : Cannabidiol, Hemp Seed

Diseases : Osteosarcoma

Pharmacological Actions : Antioxidants, Apoptotic, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Selective Cytotoxicity

[+]

Nobiletin has the potential to serve as an anti-metastatic agent for treating osteosarcoma.Jun 06, 2016

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Pubmed Data : Chem Biol Interact. 2022 Feb 25 ;354:109832. Epub 2022 Jan 24. PMID: 35085581

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Pubmed Data : Genet Mol Res. 2016;15(2). Epub 2016 Jun 10. PMID: 27323159

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

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Diseases : Advanced Glycation End products (AGE), Cancer Metastasis, Osteosarcoma

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[+]

Resveratrol suppressed the MG 63 cells by inhibiting the canonical Wnt signaling pathway.Sep 20, 2015

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Pubmed Data : Tumour Biol. 2015 Jun 24. Epub 2015 Jun 24. PMID: 26104765

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Pubmed Data : BMC Complement Med Ther. 2020 Mar 3 ;20(1):68. Epub 2020 Mar 3. PMID: 32126993

[+]

Thymoquinone potentiates methotrexate mediated-apoptosis in Saos-2 osteosarcoma cell line.Jun 26, 2022

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Pubmed Data : Drug Res (Stuttg). 2022 Jun 27. Epub 2022 Jun 27. PMID: 35760336

Article Published Date : Jun 26, 2022

Study Type : In Vitro Study

Additional Links

Substances : Thymoquinone

Diseases : Osteosarcoma

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation

Additional Keywords : Natural Substance/Drug Synergy

[+]

Tomatidine represses invasion and migration of human osteosarcoma U2OS and HOS cells.Jan 12, 2020

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Pubmed Data : Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2017 Nov 1 ;31(11):1371-1376. PMID: 29798594

Article Published Date : Oct 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Ursolic Acid

Diseases : Osteosarcoma

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation

[+]

Ursolic acid had inhibitory effects on the growth and metastatic ability of osteosarcoma cells.Aug 31, 2019

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Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2006 Sep;26(9):1293-6. PMID: 16982438

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Pubmed Data : Pharmacogn Mag. 2017 Jul-Sep;13(51):523-527. Epub 2017 Jul 19. PMID: 28839383

Article Published Date : Jun 30, 2017

Study Type : In Vitro Study

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Substances : Ashwagandha

Diseases : Osteosarcoma

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Wogonin induces apoptosis of human osteosarcoma cancer stem cells.Jun 11, 2017

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Pubmed Data : BMC Complement Altern Med. 2017 Jun 12 ;17(1):304. Epub 2017 Jun 12. PMID: 28606135

Article Published Date : Jun 11, 2017

Study Type : In Vitro Study

Additional Links

Substances : Wogonin

Diseases : Osteosarcoma

Pharmacological Actions : Apoptotic, Matrix metalloproteinase-9 (MMP-9) inhibitor

Additional Keywords : Cancer Stem Cells

[+]

Wogonin may be a promising candidate for successful clinical management of osteosarcoma.Apr 30, 2020

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Pubmed Data : RSC Adv. 2018 Aug 20 ;8(52):29637-29644. Epub 2018 Aug 21. PMID: 35547316

Article Published Date : Aug 19, 2018

Study Type : In Vitro Study

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Substances : Horse Chestnut

Diseases : Osteosarcoma

Pharmacological Actions : Antiproliferative

[+]

β-phenethyl isothiocyanate induces cell death in human osteosarcoma.Dec 31, 2019

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Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:5021983. Epub 2020 Apr 4. PMID: 32322335

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

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View the Evidence: 288 Abstracts with Osteosarcoma Research

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After 12 years from the start of the trial, the patients in the Viscum arm continue to show a considerably longer PRDFS compared to oral etoposide.Dec 31, 2019

Hyperbaric oxygen therapy may be an appropriate therapeutic regimen for the treatment of patients with osteosarcoma.Nov 01, 2009

Naringenin from Citrus aurantium inhibits osteosarcoma progression.Dec 31, 2017

Radiotherapy may result in a wide range of destructive effects in the skeletal system. Sep 01, 1998

Safety of high-dose intravenous mistletoe therapy in pediatric cancer patients: A case series.Sep 30, 2018

Several cases of osteosarcoma induced by Forteo (teriparatide) have been identified. Jul 14, 2009

SV40 is associated significantly with brain tumors, bone cancers, malignant mesothelioma, and non-Hodgkin's lymphoma.Jun 01, 2003

The data from the current study indicate an association between osteosarcoma and SV40.Feb 28, 2015

There was a significantly higher prevalence of antibodies against SV40 T antigen epitopes in serum samples from osteosarcoma patients.Dec 31, 2017

Apigenin is a promising chemotherapeutic agent that may be used in the treatment of human osteosarcoma.Jul 31, 2015

Berberine induced apoptosis and DNA damage in human osteosarcoma lines that were treated.Sep 30, 2014

Inhibition of ERK1/2 signalling pathway is involved in melatonin's antiproliferative effect on human MG-63 osteosarcoma cells.Nov 06, 2016

Piperine inhibits the proliferation of human osteosarcoma cells via G2/M phase arrest and prevents metastasis.Dec 31, 2014

SV40-like sequences are commonly found in human mesotheliomas and osteosarcomas.Jan 01, 1998

Antihyperglycemic effect of Vernonia amygdalina and in vitro evaluation of its antiproliferative activity on human osteosarcoma MG-63.Dec 31, 2021

Cinnamaldehyde decreases the invasion and u-PA expression of osteosarcoma by down-regulating the FAK signalling pathway.Jun 19, 2022

Escin induces caspase-dependent apoptosis and autophagy through the ROS/p38 MAPK signalling pathway in human osteosarcoma cells.Oct 11, 2017

Piperine improves the sensitivity of osteosarcoma cells to doxorubicin.Mar 08, 2023

A polysaccharide from Trametes robiniophila inhibits human osteosarcoma xenograft tumor growth in vivo.Jun 24, 2015

Anti-angiogenic and anti-tumor activity of Bavachinin by targeting hypoxia-inducible factor-1α.Sep 14, 2012

Anti-colorectal cancer mechanisms of formononetin identified by network pharmacological approach.Apr 30, 2019

Berberine could generate an anti-osteosarcoma property through downregulating caspase-1/IL-1β inflammatory signaling axis.Jan 31, 2017

Bufalin relieves cancer-induced pain and bone destruction.Nov 30, 2017

Cucurbitacin E can be considered to be a promising anti-cancer agent for osteosarcoma.Sep 20, 2016

Diallyl trisulfide regulates cell apoptosis and invasion in human osteosarcoma U2OS cells.Nov 30, 2020

Electroacupuncture intervention can relieve pain and morphine tolerance in bone cancer pain.Mar 24, 2019

Formononetin has inhibitory effects on the proliferation of U2SO cells.Dec 31, 2014

Forteo (teriparatide) is associated with bone cancer in rats. Jul 01, 2004

Forteo is associated with bone cancer in rats. May 01, 2002

Harmines inhibit cancer cell growth through coordinated activation of apoptosis and inhibition of autophagy.Jan 24, 2018

Hesperidin exhibits in vitro and in vivo antitumor effects in human osteosarcoma MG-63 cells and xenograft mice models.Oct 31, 2018

Honokiol induces apoptosis and autophagy in human osteosarcoma cells in vitro and in vivo.Feb 05, 2018

In vitro and in vivo studies of antiosteosarcoma activities of formononetin.Jul 31, 2019

Isoliquiritigenin inhibits mouse S180 tumors with a new mechanism that regulates autophagy by GSK-3β/TNF-α pathway.Nov 04, 2018

Kaempferol induces programmed cell death in human osteosarcoma cells.Nov 01, 2010

Licochalcone A has antitumor activities against human osteosarcoma cells.Nov 13, 2019

Shilajit potentiates the effect of chemotherapeutic drugs and mitigates metastasis induced liver and kidney damages in osteosarcoma.Aug 31, 2022

Simian virus 40 can induce cancers in hamstersJan 01, 1998

Sinomenine attenuates cancer-induced bone pain.Dec 31, 2017

Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo.Nov 01, 2007

Suppressing interleukin-6 inhibited in vivo tumour growth and metastasis.Nov 08, 2015

Tanshinone IIA enhances bystander cell killing of cancer cells.Aug 31, 2015

Tanshinone IIA induces intrinsic apoptosis in osteosarcoma cells both in vivo and in vitro.Jan 19, 2017

The anti-osteosarcoma effect from panax notoginseng saponins.Dec 31, 2020

These results suggest tanshinone IIA as a promising therapeutic agent for the treatment of osteosarcoma cancer.Sep 25, 2018

This study provides comprehensive evidence that cordycepin inhibits osteosarcoma cell growth and invasion.Dec 24, 2021

This study reveals an anti-nociceptive role for EGCG in the progression of pain caused by tumor bone metastasis. Sep 08, 2015

Toona sinensis leaf has potential to be a promising anti-osteosarcoma treatment.Aug 31, 2017

Vitamin C enhances the sensitivity of osteosarcoma to arsenic trioxide via inhibiting aerobic glycolysis.Dec 31, 2023

β-elemene enhances anticancer and anti-metastatic effects of osteosarcoma of ligustrazine in vitro and in vivo.Feb 28, 2018

Oridonin exerts anticancer effect on osteosarcoma by activating PPAR-γ and inhibiting Nrf2 pathway.Jan 10, 2018

Oridonin prevents epithelial-mesenchymal transition and TGF-β1-induced epithelial-mesenchymal transition by inhibiting TGF-β1/Smad2/3 in osteosarcoma.Dec 24, 2018

Oridonin synergizes with Nutlin-3 in osteosarcoma cells by modulating the levels of multiple Bcl-2 family proteins.May 31, 2017

"Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-κB pathway."Jan 31, 2013

"Genistein inhibits cell invasion and motility by inducing cell differentiation in murine osteosarcoma cell line LM8."Dec 31, 2011

15,16-dihydrotanshinone I induces apoptosis and inhibits the proliferation, migration of human osteosarcoma cell line 143B.Dec 31, 2016

7,8-Dihydroxyflavone suppresses proliferation and induces apoptosis of human osteosarcoma cells.Jul 04, 2021

A carotenoid extract from a cultivar of pumpkin triggers nonprotective autophagy in malignant cells.Dec 31, 2016

A crude extract of Rheum palmatum has anticancer effects in vitro against Osteosarcoma cells.Feb 16, 2015

A garlic derivative has significant anti-proliferative activity against osteosarcoma cells.Sep 01, 2009

A homogeneous polysaccharide from Huaier inhibited the proliferation of human osteosarcoma cancer cells by promoting apoptosis.Jun 30, 2015

Acacetin induces apoptosis in human osteosarcoma cells.Dec 31, 2019

Activation of the antitumor immune system by onionin A1 might be an effective adjuvant therapy for patients with malignant tumors.Dec 31, 2016

Alantolactone suppresses human osteosarcoma through the PI3K/AKT signaling pathway.Dec 31, 2019

Allicin affects immunoreactivity of osteosarcoma cells through lncRNA CBR3-AS1.Jun 14, 2024

Allicin inhibits osteosarcoma growth by promoting oxidative stress and autophagy.Dec 31, 2021

Aloe emodin and photodynamic therapy induced autophagy and apoptosis of human osteosarcoma cell line MG-63.Mar 23, 2016

Aloin induced apoptosis by enhancing autophagic flux through the PI3K/AKT axis in osteosarcoma.Nov 23, 2021

Alpha-mangostin induces apoptosis in human osteosarcoma cells.Dec 31, 2020

Andrographolide inhibits the growth of human osteosarcoma cells.Sep 24, 2022

Anti-cancer properties of quercetin in osteosarcoma.Jul 04, 2021

Anti-proliferative activity of biochanin A in human osteosarcoma cells via mitochondrial-involved apoptosis.Jan 31, 2018

Osteosarcoma

View the Evidence:
288 Abstracts with Osteosarcoma Research