Peripheral Neuropathies

Name	AC	CK
Alpha-Lipoic Acid	3	30
Vitamin D	3	22
Capsaicin	2	20
Curcumin	3	14
Vitamin C	3	14
Vitamin B-12	2	12
Ascorbyl Palmitate	1	10
Biotin	1	10
Flavonoids	1	10
Quercetin	1	10
Salt	1	10
Vitamin B-6	1	10
Berberine	3	5
Acetyl-l-carnitine	3	4
Resveratrol	2	3
Artesunate	1	2
Astragaloside	1	2
Carnitine	1	2
Fennel	1	2
Fish Oil	1	2
Flaxseed Oil	1	2
Ginkgo biloba	1	2
Glycoaminoglycans	1	2
Glycyrrhizin	1	2
Goldenthread	1	2
Hydrogen Water	1	2
Insulin-like Growth Factor (IGF-1)	1	2
Magnolol	1	2
NAC (N-acetyl-L-cysteine)	1	2
Omega-3 Fatty Acids	1	2
Sesamol	1	2
Sophora Flavescens	1	2
Tanshinone IIA	1	2
Velvet antler	1	2
Vitamin E	1	2
Benfotiamine	1	1
Cannabinoids	1	1
Cannabis	1	1
Emodin	1	1
Lotus	1	1
Nobiletin	1	1
Piceatannol	1	1
Puerarin	1	1

Name	AC	CK
Statin Drugs	8	66
Simvastatin	3	16
Cholesterol Lowering Drugs	2	13
Fenofibrates	1	10
Gliadin	1	10
Gluten	1	10
Lovastatin	2	6
Pravastatin	2	6
Atorvastatin	1	3
Infliximab	1	3
Aluminum oxide	1	2

Name	AC	CK
Acupuncture	3	31
Transcutaneous electrical nerve stimulation (TENS)	1	20
Exercise: Cycling	1	10
Photobiomodulation	3	4
Laser Treatment	2	3
Exercise	1	2
Ultrasound	1	2

Name	AC	CK	Focus
Vaccination: All	1	1
Vaccination: Influenza	1	1

[+]

Acupuncture is beneficial in some peripheral neuropathies.Feb 28, 2017

Click here to read the entire abstract

Pubmed Data : J Altern Complement Med. 2017 Mar ;23(3):164-179. Epub 2017 Jan 23. PMID: 28112552

Article Published Date : Feb 28, 2017

Study Type : Meta Analysis, Review

Additional Links

Diseases : Peripheral Neuropathies

Therapeutic Actions : Acupuncture

[+]

TENS therapy may be an effective and safe strategy in treatment of symptomatic diabetic peripheral neuropathy.Jul 01, 2010

Click here to read the entire abstract

Pubmed Data : Diabetes Res Clin Pract. 2010 Jul;89(1):10-5. Epub 2010 May 26. PMID: 20510476

Article Published Date : Jul 01, 2010

Study Type : Meta Analysis

Additional Links

Diseases : Diabetic Neuropathies, Peripheral Neuropathies

Therapeutic Actions : Transcutaneous electrical nerve stimulation (TENS)

[+]

A capsaicin 8% patch provided non-inferior pain relief to an optimized dose of pregabalin in peripheral neuropathic pain.Nov 18, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Eur J Pain. 2015 Nov 19. Epub 2015 Nov 19. PMID: 26581442

Article Published Date : Nov 18, 2015

Study Type : Human Study

Additional Links

Substances : Capsaicin

Diseases : Neuropathic Pain, Peripheral Neuropathies

Pharmacological Actions : Analgesics

Additional Keywords : Superiority of Natural Substances versus Drugs

[+]

A combination of quercetin, ascorbyl palmitate and vitamin D appears to safely offer relief of symptomatic diabetic neuropathy.Sep 01, 2005

Click here to read the entire abstract

Pubmed Data : J Diabetes Complications. 2005 Sep-Oct;19(5):247-53. PMID: 16112498

Article Published Date : Sep 01, 2005

Study Type : Human Study

Additional Links

Substances : Ascorbyl Palmitate, Quercetin, Vitamin C, Vitamin D

Diseases : Diabetes Mellitus: Type 2, Diabetic Neuropathies, Peripheral Neuropathies

Pharmacological Actions : Enzyme Inhibitors

[+]

Acetyl-l-carnitine shows promise in the treatment of diabetic peripheral neuropathy. Jan 01, 2007

Click here to read the entire abstract

Pubmed Data : CNS Drugs. 2007;21 Suppl 1:13-23; discussion 45-6. PMID: 17696589

Article Published Date : Jan 01, 2007

Study Type : Human Study

Additional Links

Diseases : Diabetic Neuropathies, Peripheral Neuropathies

Pharmacological Actions : Neuritogenic

Additional Keywords : Nerve Regeneration

[+]

Acupuncture has therapeutic value in the treatment of diabetic peripheral neuropathy. Jun 01, 2010

Click here to read the entire abstract

Pubmed Data : J Acupunct Meridian Stud. 2010 Jun;3(2):95-103. PMID: 20633522

Article Published Date : Jun 01, 2010

Study Type : Human Study

Additional Links

Diseases : Diabetic Neuropathies, Peripheral Neuropathies

Therapeutic Actions : Acupuncture

[+]

Application of a specific Abzan (salt water bath) may significantly decrease the pain of diabetic peripheral neuropathypatients.Feb 29, 2020

Click here to read the entire abstract

Pubmed Data : Complement Ther Med. 2020 Mar ;49:102325. Epub 2020 Jan 23. PMID: 32147053

Article Published Date : Feb 29, 2020

Study Type : Human Study

Additional Links

Substances : Salt

Diseases : Diabetic Ulcer, Peripheral Neuropathies

Pharmacological Actions : Analgesics

[+]

Baicalin capsules combined with α-lipoic acid are effective in treating patients with diabetic peripheral neuropathy.Dec 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Transl Res. 2021 ;13(4):2774-2783. Epub 2021 Apr 15. PMID: 34017440

Article Published Date : Dec 31, 2020

Study Type : Human Study

Additional Links

Substances : Alpha-Lipoic Acid, Flavonoids

Diseases : Peripheral Neuropathies

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Biotin improves diabetic peripheral neuropathy. Jan 01, 1990

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 1990;44(10):511-4. PMID: 2085665

Article Published Date : Jan 01, 1990

Study Type : Human Study

Additional Links

Substances : Biotin

Diseases : Diabetic Neuropathies, Peripheral Neuropathies

[+]

Capsaicin 8% for peripheral neuropathic pain treatment.Dec 31, 2021

Click here to read the entire abstract

Pubmed Data : Pain Physician. 2022 07 ;25(4):E641-E647. PMID: 35793188

Article Published Date : Dec 31, 2021

Study Type : Human Study

Additional Links

Substances : Capsaicin

Diseases : Peripheral Neuropathies

Pharmacological Actions : Analgesics

[+]

Cycle Training improves vascular function and neuropathic symptoms in patients with type 2 diabetes and peripheral neuropathy.Dec 30, 2019

Click here to read the entire abstract

Pubmed Data : Exp Gerontol. 2019 Dec 31 ;131:110799. Epub 2019 Dec 31. PMID: 31899340

Article Published Date : Dec 30, 2019

Study Type : Human Study

Additional Links

Diseases : Diabetes Mellitus: Type 2, Peripheral Neuropathies

Therapeutic Actions : Exercise: Cycling

Pharmacological Actions : Hypoglycemic Agents

[+]

Impact of vitamin B6 deficiency on the severity of diabetic peripheral neuropathy.Apr 30, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Saudi Pharm J. 2023 May ;31(5):655-658. Epub 2023 Mar 10. PMID: 37181142

Article Published Date : Apr 30, 2023

Study Type : Human Study

Additional Links

Substances : Vitamin B-6

Diseases : Diabetic Neuropathy, Peripheral Neuropathies, Vitamin B Deficiency

Pharmacological Actions : Antioxidants

[+]

Lipid lowering drugs increase the risk of peripheral neuropathy.Dec 01, 2004

Click here to read the entire abstract

Pubmed Data : J Epidemiol Community Health. 2004 Dec ;58(12):1047-51. PMID: 15547071

Article Published Date : Dec 01, 2004

Study Type : Human Study

Additional Links

Diseases : Peripheral Neuropathies, Statin-Induced Pathologies

Problem Substances : Cholesterol Lowering Drugs, Fenofibrates, Statin Drugs

Adverse Pharmacological Actions : Neurotoxic

[+]

Long-term treatment with statins caused a clinically silent but still definite damage to peripheral nerves when the treatment lasts longer than 2 years.Sep 03, 2011

Click here to read the entire abstract

Pubmed Data : Neuro Endocrinol Lett. 2011 Sep 3 ;32(5):688-690. Epub 2011 Sep 3. PMID: 22167150

Article Published Date : Sep 03, 2011

Study Type : Human Study

Additional Links

Diseases : Peripheral Neuropathies, Statin-Induced Pathologies

Problem Substances : Simvastatin, Statin Drugs

Adverse Pharmacological Actions : Neurotoxic

[+]

Long-term treatment with statins might cause a clinically silent but still electrophysiologically definite damage to peripheral nerves.Dec 01, 2007

Click here to read the entire abstract

Pubmed Data : Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2007 Dec ;151(2):307-10. PMID: 18345269

Article Published Date : Dec 01, 2007

Study Type : Human Study

Additional Links

Diseases : Peripheral Neuropathies, Statin-Induced Pathologies

Problem Substances : Statin Drugs

Adverse Pharmacological Actions : Neurotoxic

[+]

Nano-curcumin supplementation for 8 weeks was effective in reducing depression and anxiety scores in patients with diabetic polyneuropathy.Mar 31, 2020

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2020 Apr ;34(4):896-903. Epub 2019 Dec 1. PMID: 31788880

Article Published Date : Mar 31, 2020

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Anxiety, Depression, Peripheral Neuropathies

Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents

[+]

Neuropathy associated with gluten sensitivity.Mar 15, 2010

Click here to read the entire abstract

Pubmed Data : Free Radic Biol Med. 2010 Mar 15;48(6):831-838. Epub 2010 Jan 11. PMID: 16835287

Article Published Date : Mar 15, 2010

Study Type : Human Study

Additional Links

Diseases : Celiac Disease, Gluten Sensitivity, Neuropathic Pain, Peripheral Nervous System Diseases, Peripheral Neuropathies

[+]

Oral 600mg alpha-lipoic acid twice daily treatment for diabetic peripheral neuropathy over 6 months is effective, safe and tolerable.May 04, 2020

Click here to read the entire abstract

Pubmed Data : Endocr Metab Immune Disord Drug Targets. 2020 May 5. Epub 2020 May 5. PMID: 32370731

Article Published Date : May 04, 2020

Study Type : Human Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Diabetic Neuropathy, Peripheral Neuropathies

Pharmacological Actions : Neuroprotective Agents

[+]

Sensory ganglionopathy may be a manifestation of gluten sensitivity.Sep 14, 2010

Click here to read the entire abstract

Pubmed Data : Neurology. 2010 Sep 14;75(11):1003-8. PMID: 20837968

Article Published Date : Sep 14, 2010

Study Type : Human Study

Additional Links

Diseases : Celiac Disease, Gluten Sensitivity, Peripheral Neuropathies, Sensory Neuropathies

Problem Substances : Gliadin, Gluten

Adverse Pharmacological Actions : Neurotoxic

[+]

Statin drugs have been linked to neurotoxicity. Oct 01, 2006

Click here to read the entire abstract

Pubmed Data : Neth J Med. 2006 Oct ;64(9):334-8. PMID: 17057271

Article Published Date : Oct 01, 2006

Study Type : Human Study

Additional Links

Diseases : Neuropathies, Neurotoxicity, Peripheral Neuropathies, Statin-Induced Pathologies

Problem Substances : Statin Drugs

Adverse Pharmacological Actions : Neurotoxic

[+]

Statin-associated peripheral neuropathy has been recorded in the biomedical literature. Sep 01, 2004

Click here to read the entire abstract

Pubmed Data : Pharmacotherapy. 2004 Sep ;24(9):1194-203. PMID: 15460180

Article Published Date : Sep 01, 2004

Study Type : Human Study

Additional Links

Diseases : Peripheral Neuropathies, Statin-Induced Pathologies

Problem Substances : Statin Drugs

Adverse Pharmacological Actions : Neurotoxic

[+]

Tai chi chuan exercise improves fasting blood glucose and peripheral nerve conduction velocities in type 2 diabetic patients. Nov 01, 2009

Click here to read the entire abstract

Pubmed Data : J Rehabil Med. 2009 Nov;41(11):924-9. PMID: 19841845

Article Published Date : Nov 01, 2009

Study Type : Human Study

Additional Links

Diseases : Diabetes Mellitus: Type 2, Peripheral Nerve Diseases, Peripheral Neuropathies

[+]

The effect of alpha-lipoic acid on diabetic peripheral neuropathy and the upcoming depressive disorders of type II diabetics.Jan 17, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cureus. 2021 Jan 18 ;13(1):e12773. Epub 2021 Jan 18. PMID: 33614362

Article Published Date : Jan 17, 2021

Study Type : Human Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Depression, Diabetes Mellitus: Type 2, Peripheral Neuropathies

Pharmacological Actions : Antioxidants

[+]

The prevalence of peripheral neuropathy is significantly higher among those who used statins.Oct 31, 2012

Click here to read the entire abstract

Pubmed Data : J Diabetes. 2012 Nov 1. Epub 2012 Nov 1. PMID: 23121724

Article Published Date : Oct 31, 2012

Study Type : Human Study

Additional Links

Diseases : Peripheral Neuropathies

Problem Substances : Statin Drugs

Adverse Pharmacological Actions : Neurotoxic

[+]

The severity of peripheral neuropathy is associated with lower vitamin D levels.Feb 22, 2016

Click here to read the entire abstract

Pubmed Data : Support Care Cancer. 2016 Feb 23. Epub 2016 Feb 23. PMID: 26902977

Article Published Date : Feb 22, 2016

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Multiple Myeloma, Peripheral Neuropathies, Vitamin D Deficiency

Additional Keywords : 25-hydroxyvitamin D

[+]

Vitamin B12 is superior to the drug Nortriptyline in the treatment of diabetic neuropathy.Jan 01, 2009

Click here to read the entire abstract

Pubmed Data : Int J Food Sci Nutr. 2009;60 Suppl 5:71-6. Epub 2009 Feb 11. PMID: 19212856

Article Published Date : Jan 01, 2009

Study Type : Human Study

Additional Links

Substances : Vitamin B-12

Diseases : Diabetic Neuropathies, Peripheral Neuropathies

Pharmacological Actions : Anticonvulsants

Additional Keywords : Drug: Nortriptyline, Superiority of Natural Substances versus Drugs

[+]

Multiple mononeuropathy caused by treatment with pravastatin has been reporeted. Dec 01, 2006

Click here to read the entire abstract

Pubmed Data : Rev Neurol. 2006 Dec 1-15;43(11):659-61. PMID: 17133326

Article Published Date : Dec 01, 2006

Study Type : Human: Case Report

Additional Links

Diseases : Multiple Mononeuropathy, Peripheral Neuropathies

Problem Substances : Pravastatin , Statin Drugs

[+]

Peripheral neuropathy associated with simvastatin has been reported.May 01, 1995

Click here to read the entire abstract

Pubmed Data : J Neurol Neurosurg Psychiatry. 1995 May ;58(5):625-8. PMID: 7745415

Article Published Date : May 01, 1995

Study Type : Human: Case Report

Additional Links

Diseases : Peripheral Neuropathies, Statin-Induced Pathologies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Lovastatin, Simvastatin

Adverse Pharmacological Actions : Neurotoxic

[+]

Peripheral neuropathy in two patients with rheumatoid arthritis receiving infliximab treatment has been reported.Feb 01, 2007

Click here to read the entire abstract

Pubmed Data : Clin Rheumatol. 2007 Feb;26(2):258-60. Epub 2006 Jul 6. PMID: 16683176

Article Published Date : Feb 01, 2007

Study Type : Human: Case Report

Additional Links

Diseases : Peripheral Neuropathies

Problem Substances : Infliximab

Adverse Pharmacological Actions : Neurotoxic

[+]

Peripheral neuropathy induced by lipid-lowering therapy has been reported. Jul 01, 1998

Click here to read the entire abstract

Pubmed Data : South Med J. 1998 Jul ;91(7):667-8. PMID: 9671841

Article Published Date : Jul 01, 1998

Study Type : Human: Case Report

Additional Links

Diseases : Peripheral Neuropathies

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Atorvastatin, Cholesterol Lowering Drugs, Lovastatin, Pravastatin , Simvastatin, Statin Drugs

Adverse Pharmacological Actions : Neurotoxic

[+]

A polysaccharide from Sophora flavescens roots could be used safely to attenuate both inflammatory and peripheral neuropathic pain.Aug 22, 2016

Click here to read the entire abstract

Pubmed Data : Int J Biol Macromol. 2016 Aug 23. Epub 2016 Aug 23. PMID: 27565290

Article Published Date : Aug 22, 2016

Study Type : Animal Study

Additional Links

Substances : Sophora Flavescens

Diseases : Neuropathic Pain, Peripheral Neuropathies

Pharmacological Actions : Antinoceceptive

Additional Keywords : Dose Response

[+]

Acetyl-l-carnitine and resveratrol has a protective effect against chemically-induced peripheral neuropathy in rats.Aug 16, 2010

Click here to read the entire abstract

Pubmed Data : Neurosci Lett. 2010 Aug 16;480(2):117-21. Epub 2010 Jun 11. PMID: 20542088

Article Published Date : Aug 16, 2010

Study Type : Animal Study

Additional Links

Substances : Acetyl-l-carnitine, Resveratrol

Diseases : Peripheral Neuropathies

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Additional Keywords : Stilbenes

[+]

Administration of vitamins C and E in combination may exert synergistic antinociceptive effects.Dec 31, 2010

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2011 ;6(12):e29240. Epub 2011 Dec 14. PMID: 22195029

Article Published Date : Dec 31, 2010

Study Type : Animal Study

Additional Links

Substances : Vitamin C, Vitamin E

Diseases : Hyperalgesia, Inflammation, Peripheral Neuropathies

Pharmacological Actions : Analgesics, Antinoceceptive

Additional Keywords : Natural Substance Synergy

[+]

Artesunate mitigated hyperglycemia-induced nerve injury.Dec 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biol Pharm Bull. 2023 ;46(6):764-772. PMID: 37258141

Article Published Date : Dec 31, 2022

Study Type : Animal Study

Additional Links

Substances : Artesunate

Diseases : Peripheral Neuropathies

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

[+]

Astragaloside IV inhibits mitochondrial-dependent apoptosis of the dorsal root ganglion in diabetic peripheral neuropathy.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Diabetes Metab Syndr Obes. 2021 ;14:1647-1661. Epub 2021 Apr 14. PMID: 33883914

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Peripheral Neuropathies

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

[+]

Berberine promotes neurite extension and axonal regeneration in injured nerves of the peripheral nervous systemApr 01, 2012

Click here to read the entire abstract

Pubmed Data : J Med Food. 2012 Apr ;15(4):413-7. Epub 2012 Feb 8. PMID: 22316297

Article Published Date : Apr 01, 2012

Study Type : Animal Study

Additional Links

Substances : Berberine, Goldenthread

Diseases : Demyelinating Diseases, Peripheral Nerve Diseases, Peripheral Neuropathies

Pharmacological Actions : Neuritogenic

Additional Keywords : Nerve Regeneration, Remyelination, Sciatic Nerve

[+]

Carnitine can be used to increase regeneration following peripheral nerve damage.Dec 29, 2016

Click here to read the entire abstract

Pubmed Data : J Craniofac Surg. 2016 Dec 30. Epub 2016 Dec 30. PMID: 28045825

Article Published Date : Dec 29, 2016

Study Type : Animal Study

Additional Links

Substances : Carnitine

Diseases : Peripheral Neuropathies

Pharmacological Actions : Regenerative

Additional Keywords : Nerve Regeneration

[+]

Chitosan nanoparticles loaded with Foeniculum vulgare extract regulate retrieval of sensory and motor functions in mice.Feb 14, 2024

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Heliyon. 2024 Feb 15 ;10(3):e25414. Epub 2024 Jan 29. PMID: 38352784

Article Published Date : Feb 14, 2024

Study Type : Animal Study

Additional Links

Substances : Fennel

Diseases : Peripheral Neuropathies

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Nerve Regeneration

[+]

Curcumin treatment may have a therapeutic role in treating selected forms of inherited peripheral neuropathies.Nov 01, 2005

Click here to read the entire abstract

Pubmed Data : Am J Hum Genet. 2005 Nov;77(5):841-50. Epub 2005 Sep 30. PMID: 16252242

Article Published Date : Nov 01, 2005

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Charcot-Marie-Tooth Disease, Dejerine-Sottas Disease, Peripheral Neuropathies

Pharmacological Actions : Apoptotic

[+]

Cyanocobalamin and cholecalciferol synergistically improve functional and histopathological nerve healing.Mar 29, 2020

Click here to read the entire abstract

Pubmed Data : Ideggyogy Sz. 2020 Mar 30 ;73(3-4):113-120. PMID: 32364338

Article Published Date : Mar 29, 2020

Study Type : Animal Study

Additional Links

Substances : Vitamin B-12, Vitamin D

Diseases : Peripheral Neuropathies

Pharmacological Actions : Regenerative

Additional Keywords : Natural Substance Synergy, Nerve Regeneration

[+]

Effect of bilobalide on peripheral nerve regeneration.Jan 31, 2004

Click here to read the entire abstract

Pubmed Data : Biomaterials. 2004 Feb ;25(3):509-14. PMID: 14585700

Article Published Date : Jan 31, 2004

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Peripheral Neuropathies

Pharmacological Actions : Neuroprotective Agents, Regenerative

Additional Keywords : Nerve Regeneration

[+]

Effect of sesamol on damaged peripheral nerves: Evaluation of functional, histological, molecular, and oxidative stress parameters.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Avicenna J Phytomed. 2022 ;12(6):602-613. PMID: 36583179

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Sesamol

Diseases : Nerve Entrapments, Peripheral Neuropathies

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

Glycosaminoglycans boost insulin-like growth factor-I-promoted neuroprotection, indicating their potential value in motor neuron disease and peripheral neuropathies.Jan 01, 1999

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Pubmed Data : Neuroscience. 1999;93(2):565-72. PMID: 10465440

Article Published Date : Jan 01, 1999

Study Type : Animal Study

Additional Links

Substances : Glycoaminoglycans, Insulin-like Growth Factor (IGF-1)

Diseases : Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Peripheral Neuropathies

Pharmacological Actions : Apoptotic, Neuroprotective Agents

Additional Keywords : Drug Synergy

[+]

Glycyrrhizic acid promotes sciatic nerves recovery in type 1 diabetic rats and protects Schwann cells from high glucose-induced cytotoxicity.May 14, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Biomed Res. 2022 May 15 ;36(3):181-194. PMID: 35578754

Article Published Date : May 14, 2022

Study Type : Animal Study

Additional Links

Substances : Glycyrrhizin

Diseases : Diabetic Nephropathy, Peripheral Neuropathies

Pharmacological Actions : Neuroprotective Agents

[+]

Hydrogen-rich saline promotes motor functional recovery following peripheral nerve autografting in rats.Jul 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Ther Med. 2015 Aug ;10(2):727-732. Epub 2015 May 26. PMID: 26622383

Article Published Date : Jul 31, 2015

Study Type : Animal Study

Additional Links

Substances : Hydrogen Water

Diseases : Peripheral Neuropathies

Pharmacological Actions : Neuroprotective Agents

[+]

Laser treatment induces peripheral nerve regeneration.Jun 01, 2007

Click here to read the entire abstract

Pubmed Data : Photomed Laser Surg. 2007 Jun;25(3):137-43. PMID: 17603852

Article Published Date : Jun 01, 2007

Study Type : Animal Study

Additional Links

Diseases : Peripheral Nerve Diseases, Peripheral Neuropathies

Therapeutic Actions : Laser Treatment

Additional Keywords : Remyelination

[+]

Low-level laser therapy is more safe and effective than gabapentin in the management of neuropathy in diabetic rats.Mar 11, 2018

Click here to read the entire abstract

Pubmed Data : Appl Biochem Biotechnol. 2018 Mar 12. Epub 2018 Mar 12. PMID: 29527628

Article Published Date : Mar 11, 2018

Study Type : Animal Study

Additional Links

Diseases : Peripheral Neuropathies

Therapeutic Actions : Photobiomodulation

Additional Keywords : Superiority of Natural Substances versus Drugs

[+]

Magnolol effectively ameliorates diabetic peripheral neuropathy in mice.Sep 04, 2022

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2022 Sep 5 ;107:154434. Epub 2022 Sep 5. PMID: 36122436

Article Published Date : Sep 04, 2022

Study Type : Animal Study

Additional Links

Substances : Magnolol

Diseases : Diabetic Nephropathy, Peripheral Neuropathies

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, NF-kappaB Inhibitor

[+]

NAC could improve the peripheral neuropathy in cirrhotic rat through suppression of MEG3/PAR2 expression.Nov 17, 2019

Click here to read the entire abstract

Pubmed Data : Neurochem Int. 2019 Nov 18:104602. Epub 2019 Nov 18. PMID: 31751619

Article Published Date : Nov 17, 2019

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Liver Cirrhosis, Peripheral Neuropathies

Pharmacological Actions : Hepatoprotective, Neuroprotective Agents

[+]

Omega-3 polyunsaturated fatty acids derived from fish oil could be an effective treatment for neural and vascular complications associated with obesity.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Diabetes Metab Syndr Obes. 2018 ;11:117-127. Epub 2018 Apr 9. PMID: 29674850

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Fish Oil, Flaxseed Oil, Omega-3 Fatty Acids

Diseases : Obesity, Peripheral Neuropathies

[+]

Oral curcumin may have therapeutic activity in treating inherited peripheral neuropathies.Sep 01, 2007

Click here to read the entire abstract

Pubmed Data : Am J Hum Genet. 2007 Sep;81(3):438-53. Epub 2007 Aug 3. PMID: 17701891

Article Published Date : Sep 01, 2007

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Charcot-Marie-Tooth Disease, Dejerine-Sottas Disease, Demyelinating Diseases, Peripheral Neuropathies

Pharmacological Actions : Apoptotic

[+]

Tanshinone II A affects diabetic peripheral neuropathic pain.Jul 10, 2019

Click here to read the entire abstract

Pubmed Data : Exp Clin Endocrinol Diabetes. 2019 Jul 11. Epub 2019 Jul 11. PMID: 31295750

Article Published Date : Jul 10, 2019

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Diabetic Nephropathy, Peripheral Neuropathies

Pharmacological Actions : Analgesics

[+]

The antiviral alkaloid berberine ameliorates neuropathic pain in rats with peripheral nerve injury.Aug 29, 2018

Click here to read the entire abstract

Pubmed Data : Acta Neurol Belg. 2018 Aug 30. Epub 2018 Aug 30. PMID: 30168114

Article Published Date : Aug 29, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Neuropathic Pain, Peripheral Neuropathies

Pharmacological Actions : MicroRNA modulator

[+]

Therapeutic ultrasound in combination with treadmill training reduces neuropathic pain more than either modality alone.Apr 27, 2016

Click here to read the entire abstract

Pubmed Data : Phys Ther. 2016 Apr 28. Epub 2016 Apr 28. PMID: 27126126

Article Published Date : Apr 27, 2016

Study Type : Animal Study

Additional Links

Diseases : Peripheral Neuropathies

Therapeutic Actions : Exercise, Ultrasound

Pharmacological Actions : Analgesics, Interleukin-10 upregulation, Interleukin-6 Downregulation

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These findings suggest that aluminium may be considered toxic for the peripheral nervous system.Aug 24, 2017

Click here to read the entire abstract

Pubmed Data : J Inorg Biochem. 2017 Aug 25. Epub 2017 Aug 25. PMID: 28865725

Article Published Date : Aug 24, 2017

Study Type : Animal Study

Additional Links

Diseases : Aluminum Toxicity , Peripheral Neuropathies

Additional Keywords : aluminum, aluminum toxicity, Peripheral Neuropathies, Risk Factors

Problem Substances : Aluminum oxide

[+]

Velvet antler polypeptide induce peripheral nerve regeneration.Dec 01, 2008

Click here to read the entire abstract

Pubmed Data : Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2008 Dec;22(12):1458-61. PMID: 19137890

Article Published Date : Dec 01, 2008

Study Type : Animal Study

Additional Links

Substances : Velvet antler

Diseases : Peripheral Nerve Diseases, Peripheral Neuropathies

Pharmacological Actions : Neuritogenic

Additional Keywords : Nerve Regeneration

[+]

Vitamin C regulates Schwann cell myelination by promoting DNA demethylation of pro-myelinating genes.Mar 25, 2020

Click here to read the entire abstract

Pubmed Data : J Neurochem. 2020 Mar 26. Epub 2020 Mar 26. PMID: 32219848

Article Published Date : Mar 25, 2020

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Peripheral Neuropathies

Pharmacological Actions : Remyelination

Additional Keywords : Gene Expression Regulation

[+]

A review of cannabis and cannabinoids and their benefits in many health conditions. May 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Clin Pharmacol Ther. 2015 Jun ;97(6):575-86. Epub 2015 Apr 17. PMID: 25777363

Article Published Date : May 31, 2015

Study Type : Review

Additional Links

Substances : Cannabinoids , Cannabis

Diseases : AIDS, Cachexia: Cancer, Cancer: Pain , Cancers: All, Peripheral Neuropathies

Pharmacological Actions : Analgesics, Antiproliferative , Apoptotic, Appetite Stimulants, Chemopreventive

Additional Keywords : Natural Substance/Drug Synergy

[+]

A review on recent advances on nobiletin in central and peripheral nervous system diseases.Nov 05, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Eur J Med Res. 2023 Nov 6 ;28(1):485. Epub 2023 Nov 6. PMID: 37932838

Article Published Date : Nov 05, 2023

Study Type : Review

Additional Links

Substances : Nobiletin

Diseases : Central Nervous System Diseases, Oxidative Stress, Peripheral Neuropathies

Pharmacological Actions : Antioxidants, Neuroprotective Agents

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Acetyl-l-carnitine has significant therapeutic value in the treatment of neuropathic pain. Jan 01, 2007

Click here to read the entire abstract

Pubmed Data : CNS Drugs.2007;21 Suppl 1:31-8; discussion 45-6. PMID: 17696591

Article Published Date : Jan 01, 2007

Study Type : Review

Additional Links

Substances : Acetyl-l-carnitine

Diseases : Neuropathic Pain, Peripheral Neuropathies

Pharmacological Actions : Antinoceceptive

[+]

Acetyl-l-carnitine has therapeutic activity in treating chemotherapy-induced peripheral neuropathy. Jan 01, 2007

Click here to read the entire abstract

Pubmed Data : CNS Drugs. 2007;21 Suppl 1:39-43; discussion 45-6. PMID: 17696592

Article Published Date : Jan 01, 2007

Study Type : Review

Additional Links

Substances : Acetyl-l-carnitine

Diseases : Chemotherapy-Induced Toxicity: Peripheral Neuropathy, Peripheral Neuropathies

[+]

Acupuncture appears to have an effect on diabetic peripheral neuropathy.Jan 27, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Clin Pharm Ther. 2021 Jan 28. Epub 2021 Jan 28. PMID: 33511675

Article Published Date : Jan 27, 2021

Study Type : Review

Additional Links

Diseases : Peripheral Neuropathies

Therapeutic Actions : Acupuncture

Pharmacological Actions : Neuroprotective Agents

[+]

Benfotiamine has antioxidant activity and may protect DNA.Jul 01, 2008

Click here to read the entire abstract

Pubmed Data : Diabetes Metab Res Rev. 2008 Jul;24(5):371-7. PMID: 18384109

Article Published Date : Jul 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Benfotiamine

Diseases : DNA damage, Peripheral Neuropathies

Pharmacological Actions : Antioxidants

[+]

Effects of low-energy He-Ne laser irradiation on posttraumatic degeneration of adult rabbit optic nerve.Dec 31, 1986

Click here to read the entire abstract

Pubmed Data : Lasers Surg Med. 1987 ;7(1):51-5. PMID: 3573936

Article Published Date : Dec 31, 1986

Study Type : In Vitro Study

Additional Links

Diseases : Optic Nerve Diseases, Peripheral Neuropathies

Therapeutic Actions : Photobiomodulation

Pharmacological Actions : Neuroprotective Agents

[+]

Improving sciatic nerve regeneration by using alginate/chitosan hydrogel containing berberine.Oct 08, 2020

Click here to read the entire abstract

Pubmed Data : Drug Deliv Transl Res. 2020 Oct 9. Epub 2020 Oct 9. PMID: 33034886

Article Published Date : Oct 08, 2020

Study Type : In Vitro Study

Additional Links

Substances : Berberine

Diseases : Peripheral Neuropathies

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Nerve Regeneration

[+]

Influenza vaccines may induce hepatitis-B virus-related vasculitis and severe neuropathy.Sep 01, 2003

Click here to read the entire abstract

Pubmed Data : J Cardiovasc Pharmacol. 2003 Sep;42(3):329-38. PMID: 18579284

Article Published Date : Sep 01, 2003

Study Type : Commentary

Additional Links

Diseases : Peripheral Neuropathies, Vasculitis

Anti Therapeutic Actions : Vaccination: All, Vaccination: Influenza

[+]

Laser phototherapy accelerates and enhances axonal growth and regeneration after injury or a reconstructive peripheral nerve procedure. Feb 01, 2009

Click here to read the entire abstract

Pubmed Data : Neurosurg Focus. 2009 Feb;26(2):E8. PMID: 19199510

Article Published Date : Feb 01, 2009

Study Type : Review

Additional Links

Diseases : Neurologic Disorders, Peripheral Nerve Diseases, Peripheral Neuropathies

Therapeutic Actions : Laser Treatment

[+]

Lotus essential oil improves neurite elongation and facilitates functional recovery after peripheral nerve injury.Mar 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Rep. 2022 Apr ;16(4):30. Epub 2022 Feb 18. PMID: 35251617

Article Published Date : Mar 31, 2022

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Peripheral Neuropathies

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Essential Oils

[+]

Low level laser therapy has a positive effect in controlling diabetic neuropathic pain.Jul 31, 2019

Click here to read the entire abstract

Pubmed Data : Diabetes Metab Syndr. 2019 Jul - Aug;13(4):2667-2670. Epub 2019 Jul 13. PMID: 31405692

Article Published Date : Jul 31, 2019

Study Type : Review

Additional Links

Diseases : Peripheral Neuropathies

Therapeutic Actions : Photobiomodulation

[+]

Natural compounds acting at P2 receptors alleviate peripheral neuropathy.Dec 28, 2018

Click here to read the entire abstract

Pubmed Data : Brain Res Bull. 2018 Dec 29. Epub 2018 Dec 29. PMID: 30599217

Article Published Date : Dec 28, 2018

Study Type : Review

Additional Links

Substances : Emodin, Puerarin, Resveratrol

Diseases : Peripheral Neuropathies

Pharmacological Actions : Antinoceceptive

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View the Evidence: 71 Abstracts with Peripheral Neuropathies Research

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Acupuncture is beneficial in some peripheral neuropathies.Feb 28, 2017

TENS therapy may be an effective and safe strategy in treatment of symptomatic diabetic peripheral neuropathy.Jul 01, 2010

A capsaicin 8% patch provided non-inferior pain relief to an optimized dose of pregabalin in peripheral neuropathic pain.Nov 18, 2015

A combination of quercetin, ascorbyl palmitate and vitamin D appears to safely offer relief of symptomatic diabetic neuropathy.Sep 01, 2005

Acetyl-l-carnitine shows promise in the treatment of diabetic peripheral neuropathy. Jan 01, 2007

Acupuncture has therapeutic value in the treatment of diabetic peripheral neuropathy. Jun 01, 2010

Application of a specific Abzan (salt water bath) may significantly decrease the pain of diabetic peripheral neuropathypatients.Feb 29, 2020

Baicalin capsules combined with α-lipoic acid are effective in treating patients with diabetic peripheral neuropathy.Dec 31, 2020

Biotin improves diabetic peripheral neuropathy. Jan 01, 1990

Capsaicin 8% for peripheral neuropathic pain treatment.Dec 31, 2021

Cycle Training improves vascular function and neuropathic symptoms in patients with type 2 diabetes and peripheral neuropathy.Dec 30, 2019

Impact of vitamin B6 deficiency on the severity of diabetic peripheral neuropathy.Apr 30, 2023

Lipid lowering drugs increase the risk of peripheral neuropathy.Dec 01, 2004

Long-term treatment with statins caused a clinically silent but still definite damage to peripheral nerves when the treatment lasts longer than 2 years.Sep 03, 2011

Long-term treatment with statins might cause a clinically silent but still electrophysiologically definite damage to peripheral nerves.Dec 01, 2007

Nano-curcumin supplementation for 8 weeks was effective in reducing depression and anxiety scores in patients with diabetic polyneuropathy.Mar 31, 2020

Neuropathy associated with gluten sensitivity.Mar 15, 2010

Oral 600mg alpha-lipoic acid twice daily treatment for diabetic peripheral neuropathy over 6 months is effective, safe and tolerable.May 04, 2020

Sensory ganglionopathy may be a manifestation of gluten sensitivity.Sep 14, 2010

Statin drugs have been linked to neurotoxicity. Oct 01, 2006

Statin-associated peripheral neuropathy has been recorded in the biomedical literature. Sep 01, 2004

Tai chi chuan exercise improves fasting blood glucose and peripheral nerve conduction velocities in type 2 diabetic patients. Nov 01, 2009

The effect of alpha-lipoic acid on diabetic peripheral neuropathy and the upcoming depressive disorders of type II diabetics.Jan 17, 2021

The prevalence of peripheral neuropathy is significantly higher among those who used statins.Oct 31, 2012

The severity of peripheral neuropathy is associated with lower vitamin D levels.Feb 22, 2016

Vitamin B12 is superior to the drug Nortriptyline in the treatment of diabetic neuropathy.Jan 01, 2009

Multiple mononeuropathy caused by treatment with pravastatin has been reporeted. Dec 01, 2006

Peripheral neuropathy associated with simvastatin has been reported.May 01, 1995

Peripheral neuropathy in two patients with rheumatoid arthritis receiving infliximab treatment has been reported.Feb 01, 2007

Peripheral neuropathy induced by lipid-lowering therapy has been reported. Jul 01, 1998

A polysaccharide from Sophora flavescens roots could be used safely to attenuate both inflammatory and peripheral neuropathic pain.Aug 22, 2016

Acetyl-l-carnitine and resveratrol has a protective effect against chemically-induced peripheral neuropathy in rats.Aug 16, 2010

Administration of vitamins C and E in combination may exert synergistic antinociceptive effects.Dec 31, 2010

Artesunate mitigated hyperglycemia-induced nerve injury.Dec 31, 2022

Astragaloside IV inhibits mitochondrial-dependent apoptosis of the dorsal root ganglion in diabetic peripheral neuropathy.Dec 31, 2020

Berberine promotes neurite extension and axonal regeneration in injured nerves of the peripheral nervous systemApr 01, 2012

Carnitine can be used to increase regeneration following peripheral nerve damage.Dec 29, 2016

Chitosan nanoparticles loaded with Foeniculum vulgare extract regulate retrieval of sensory and motor functions in mice.Feb 14, 2024

Curcumin treatment may have a therapeutic role in treating selected forms of inherited peripheral neuropathies.Nov 01, 2005

Cyanocobalamin and cholecalciferol synergistically improve functional and histopathological nerve healing.Mar 29, 2020

Effect of bilobalide on peripheral nerve regeneration.Jan 31, 2004

Effect of sesamol on damaged peripheral nerves: Evaluation of functional, histological, molecular, and oxidative stress parameters.Dec 31, 2021

Glycosaminoglycans boost insulin-like growth factor-I-promoted neuroprotection, indicating their potential value in motor neuron disease and peripheral neuropathies.Jan 01, 1999

Glycyrrhizic acid promotes sciatic nerves recovery in type 1 diabetic rats and protects Schwann cells from high glucose-induced cytotoxicity.May 14, 2022

Hydrogen-rich saline promotes motor functional recovery following peripheral nerve autografting in rats.Jul 31, 2015

Laser treatment induces peripheral nerve regeneration.Jun 01, 2007

Low-level laser therapy is more safe and effective than gabapentin in the management of neuropathy in diabetic rats.Mar 11, 2018

Magnolol effectively ameliorates diabetic peripheral neuropathy in mice.Sep 04, 2022

NAC could improve the peripheral neuropathy in cirrhotic rat through suppression of MEG3/PAR2 expression.Nov 17, 2019

Omega-3 polyunsaturated fatty acids derived from fish oil could be an effective treatment for neural and vascular complications associated with obesity.Dec 31, 2017

Oral curcumin may have therapeutic activity in treating inherited peripheral neuropathies.Sep 01, 2007

Tanshinone II A affects diabetic peripheral neuropathic pain.Jul 10, 2019

The antiviral alkaloid berberine ameliorates neuropathic pain in rats with peripheral nerve injury.Aug 29, 2018

Therapeutic ultrasound in combination with treadmill training reduces neuropathic pain more than either modality alone.Apr 27, 2016

These findings suggest that aluminium may be considered toxic for the peripheral nervous system.Aug 24, 2017

Velvet antler polypeptide induce peripheral nerve regeneration.Dec 01, 2008

Vitamin C regulates Schwann cell myelination by promoting DNA demethylation of pro-myelinating genes.Mar 25, 2020

A review of cannabis and cannabinoids and their benefits in many health conditions. May 31, 2015

A review on recent advances on nobiletin in central and peripheral nervous system diseases.Nov 05, 2023

Acetyl-l-carnitine has significant therapeutic value in the treatment of neuropathic pain. Jan 01, 2007

Acetyl-l-carnitine has therapeutic activity in treating chemotherapy-induced peripheral neuropathy. Jan 01, 2007

Acupuncture appears to have an effect on diabetic peripheral neuropathy.Jan 27, 2021

Benfotiamine has antioxidant activity and may protect DNA.Jul 01, 2008

Effects of low-energy He-Ne laser irradiation on posttraumatic degeneration of adult rabbit optic nerve.Dec 31, 1986

Improving sciatic nerve regeneration by using alginate/chitosan hydrogel containing berberine.Oct 08, 2020

Influenza vaccines may induce hepatitis-B virus-related vasculitis and severe neuropathy.Sep 01, 2003

Laser phototherapy accelerates and enhances axonal growth and regeneration after injury or a reconstructive peripheral nerve procedure. Feb 01, 2009

Lotus essential oil improves neurite elongation and facilitates functional recovery after peripheral nerve injury.Mar 31, 2022

Low level laser therapy has a positive effect in controlling diabetic neuropathic pain.Jul 31, 2019

Natural compounds acting at P2 receptors alleviate peripheral neuropathy.Dec 28, 2018

Piceatannol promotes neuroprotection in experimental diabetic peripheral neuropathy and hyperglycemia-induced neurotoxicity.Feb 28, 2023

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Peripheral Neuropathies

View the Evidence:
71 Abstracts with Peripheral Neuropathies Research