Phthalate Toxicity

Name	AC	CK
Celery Oil	3	6
Curcumin	3	6
Antioxidant formulas	1	2
Celery seed	1	2
Garcinia kola	1	2
Quercetin	1	2
Resveratrol	1	2
Vitamin E	1	2

Name	AC	CK
Phthalates	14	65
Bisphenol A	4	22
Endocrine Disrupting Chemicals (EDCs)	1	10
Perfluorinated compounds	1	10
Triclosan	1	10

Name	AC	CK	Focus
Sweating	1	10

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Association of phthalate exposure with precocious and delayed pubertal timing in girls and boys.Feb 23, 2020

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Pubmed Data : Environ Sci Process Impacts. 2020 Feb 24. Epub 2020 Feb 24. PMID: 32091510

Article Published Date : Feb 23, 2020

Study Type : Meta Analysis, Review

Additional Links

Diseases : Phthalate Toxicity , Puberty: Delayed, Puberty: Precocious

Additional Keywords : Increased Risk

Problem Substances : Phthalates

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Prenatal phthalate exposure and altered patterns of DNA methylation in cord blood.Jun 30, 2017

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Pubmed Data : Environ Mol Mutagen. 2017 Jul ;58(6):398-410. Epub 2017 May 28. PMID: 28556291

Article Published Date : Jun 30, 2017

Study Type : Meta Analysis

Additional Links

Diseases : Phthalate Toxicity , Prenatal Chemical Exposures

Additional Keywords : DNA Methylation, Hypomethylation

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Click here to read the entire abstract

Pubmed Data : Environ Res. 2021 Mar 7 ;197:110981. Epub 2021 Mar 7. PMID: 33691158

Article Published Date : Mar 06, 2021

Study Type : Human Study

Additional Links

Diseases : Asthma, Phthalate Toxicity

Additional Keywords : Risk Factors

Problem Substances : Phthalates

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Early-life DEHP exposure alter gut microbiota of newborns and may change their immune responses in later life.Jul 25, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Food Chem Toxicol. 2019 Jul 26:110700. Epub 2019 Jul 26. PMID: 31356917

Article Published Date : Jul 25, 2019

Study Type : Human Study

Additional Links

Diseases : Phthalate Toxicity

Additional Keywords : Microbiota

Problem Substances : Phthalates

Adverse Pharmacological Actions : Immunoreactive

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Early-life phthalate exposure was found to be associated with the behavioural characteristics of children.Jan 09, 2020

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Pubmed Data : Sci Total Environ. 2020 Jan 10 ;699:134053. Epub 2019 Aug 29. PMID: 31678884

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Pubmed Data : Environ Res. 2017 Oct 10 ;160:239-246. Epub 2017 Oct 10. PMID: 29028488

Article Published Date : Oct 09, 2017

Study Type : Human Study

Additional Links

Diseases : Phthalate Toxicity , Placental Insufficiency, Prenatal Chemical Exposures

Problem Substances : Phthalates

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Exposure to environmental phthalates have the potential to alter circulating levels of thyroid hormones in pregnant women.Oct 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Environ Health Perspect. 2016 Nov ;124(11):1808-1815. Epub 2016 Aug 6. PMID: 27152641

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Environ Sci Technol. 2022 Jun 21 ;56(12):8416-8427. Epub 2022 May 18. PMID: 35584204

Article Published Date : Jun 20, 2022

Study Type : Human Study

Additional Links

Diseases : Inflammation, Phthalate Toxicity

Problem Substances : Phthalates

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Induced perspiration may be useful to facilitate elimination of some potentially toxic phthalate compounds including DEHP and MEHP.Dec 31, 2011

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : ScientificWorldJournal. 2012 ;2012:615068. Epub 2012 Oct 31. PMID: 23213291

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Immunol. 2021 ;12:599345. Epub 2021 Feb 15. PMID: 33659001

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Pubmed Data : Environ Res. 2019 Dec ;179(Pt B):108829. Epub 2019 Oct 18. PMID: 31677502

Article Published Date : Nov 30, 2019

Study Type : Human Study

Additional Links

Diseases : Neurodevelopmental Disorders, Phthalate Toxicity

Problem Substances : Phthalates

Adverse Pharmacological Actions : Neurotoxic

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Phthalate exposure enhances incidence of urinary incontinence.Apr 26, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Allergy Asthma Immunol Res. 2022 May ;14(3):339-343. PMID: 35557498

Article Published Date : Apr 30, 2022

Study Type : Human Study

Additional Links

Diseases : Asthma, Phthalate Toxicity , Urticaria

Additional Keywords : Increased Risk

Problem Substances : Phthalates

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There was an association between total phthalate concentration and non-communicable diseases and chronic inflammation in men.Jul 03, 2017

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Pubmed Data : Environ Res. 2017 Jul 4 ;158:366-372. Epub 2017 Jul 4. PMID: 28686951

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Article Publish Status : This is a free article. Click here to read the complete article.

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Antoxidants can protect the testes from phthalate induced toxicity. Apr 01, 2000

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Pubmed Data : Int J Androl. 2000 Apr;23(2):85-94. PMID: 10762434

Article Published Date : Apr 01, 2000

Study Type : Animal Study

Additional Links

Substances : Antioxidant formulas

Diseases : Phthalate Toxicity

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Ascorbic acid ameliorates dysregulated folliculogenesis induced by mono-(2-ethylhexyl)phthalate in neonatal mouse ovaries.Aug 02, 2020

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Pubmed Data : Reprod Domest Anim. 2020 Aug 3. Epub 2020 Aug 3. PMID: 32744352

Article Published Date : Aug 02, 2020

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Phthalate Toxicity

Pharmacological Actions : Antioxidants

Problem Substances : Phthalates

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Celery oil seed extract ameliorated the toxicological effects of DEHP in rats.Mar 31, 2015

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Pubmed Data : Toxicol Ind Health. 2015 Apr ;31(4):355-66. Epub 2013 Feb 1. PMID: 23377116

Article Published Date : Mar 31, 2015

Study Type : Animal Study

Additional Links

Substances : Celery Oil, Celery seed

Diseases : Phthalate Toxicity

Pharmacological Actions : Hepatoprotective, Hypolipidemic

Additional Keywords : Plant Extracts

Problem Substances : Phthalates

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Curcumin (from Turmeric) and kolaviron (a compound from the seeds of Garcinia kola) ameliorate phthalate-induced testicular damage in rats. Jan 01, 2007

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Pubmed Data : Basic Clin Pharmacol Toxicol. 2007 Jan;100(1):43-8. PMID: 17214610

Article Published Date : Jan 01, 2007

Study Type : Animal Study

Additional Links

Substances : Curcumin, Garcinia kola

Diseases : Phthalate Toxicity

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Effects of Lycium barbarum glycopeptide on renal and testicular injury induced by di(2-ethylhexyl) phthalate.Mar 31, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell Stress Chaperones. 2022 Apr 1. Epub 2022 Apr 1. PMID: 35362893

Article Published Date : Mar 31, 2022

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Long-term dietary administration of diethyl phthalate triggers loss of insulin sensitivity in two key insulin target tissues of mice.Mar 03, 2020

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Pubmed Data : Hum Exp Toxicol. 2020 Mar 4:960327120909526. Epub 2020 Mar 4. PMID: 32129097

Article Published Date : Mar 03, 2020

Study Type : Animal Study

Additional Links

Diseases : Diabetes Mellitus: Type 2, Insulin Resistance, Metabolic Diseases, Phthalate Toxicity

Additional Keywords : Risk Factors

Problem Substances : Phthalates

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Low dose of genistein alleviates phthalate-induced fetal testis disorder.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:4569268. Epub 2020 May 27. PMID: 32566080

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Phthalate Toxicity , Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Antioxidants

Problem Substances : Phthalates

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Lycium barbarum polysaccharides and Wolfberry juice prevent DEHP-induced hepatotoxicity.Feb 05, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2021 Feb 6 ;26(4). Epub 2021 Feb 6. PMID: 33562043

Pubmed Data : Sci Total Environ. 2022 May 9:155813. Epub 2022 May 9. PMID: 35550907

Article Published Date : May 08, 2022

Study Type : Animal Study

Additional Links

Diseases : Inflammation, Oxidative Stress, Phthalate Toxicity

Problem Substances : Phthalates

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Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture.Jul 05, 2020

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Pubmed Data : Food Chem Toxicol. 2020 Jul 6:111540. Epub 2020 Jul 6. PMID: 32645469

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Reprod Biol Endocrinol. 2021 Sep 18 ;19(1):146. Epub 2021 Sep 18. PMID: 34537068

Article Published Date : Sep 17, 2021

Vitamin E and curcumin can alleviate dibutyl phthalate-induced splenic injury.Nov 07, 2019

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Pubmed Data : Food Chem Toxicol. 2019 Nov 8:110955. Epub 2019 Nov 8. PMID: 31712109

Article Published Date : Nov 07, 2019

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Pubmed Data : Oncol Lett. 2016 Feb ;11(2):1035-1042. Epub 2015 Dec 7. PMID: 26893687

Article Published Date : Jan 31, 2016

Study Type : In Vitro Study

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Pubmed Data : Toxicol Appl Pharmacol. 2017 Aug 15 ;329:158-164. PMID: 28595985

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2020 Mar 20 ;21(6). Epub 2020 Mar 20. PMID: 32244920

Article Published Date : Mar 19, 2020

Study Type : In Vitro Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus)

Diseases : Phthalate Toxicity

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents, Nrf2 activation

Problem Substances : Phthalates

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Lycopene prevents DEHP-induced hepatic oxidative stress damage by crosstalk between AHR-Nrf2 pathway.Sep 14, 2021

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Pubmed Data : Environ Pollut. 2021 Sep 15 ;285:117080. Epub 2021 Apr 7. PMID: 33965855

Protective effects of polyphenols against endocrine disrupting chemicals.Jun 30, 2022

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Pubmed Data : Food Sci Biotechnol. 2022 Jul ;31(8):905-934. Epub 2022 Jul 12. PMID: 35873371

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Pubmed Data : Environ Sci Pollut Res Int. 2017 Oct ;24(30):23903-23914. Epub 2017 Sep 5. PMID: 28875446

Article Published Date : Sep 30, 2017

Study Type : In Vitro Study

Additional Links

Diseases : DNA damage, Phthalate Toxicity

Additional Keywords : Risk Factors

Problem Substances : Perfume: Synthetic, Phthalates

Adverse Pharmacological Actions : Genotoxic

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Worldwide bottled water occurrence of emerging contaminants.Jan 14, 2020

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Pubmed Data : J Hazard Mater. 2020 06 15 ;392:122271. Epub 2020 Feb 14. PMID: 32311916

Article Published Date : Jan 14, 2020

Study Type : Review

Additional Links

Diseases : Bisphenol Toxicity, Phthalate Toxicity

Additional Keywords : Bottled Water, Microplastic, Plastic Bottle

Problem Substances : Bisphenol A , Phthalates

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View the Evidence: 144 Abstracts with Phthalate Toxicity Research

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Association of phthalate exposure with precocious and delayed pubertal timing in girls and boys.Feb 23, 2020

Prenatal phthalate exposure and altered patterns of DNA methylation in cord blood.Jun 30, 2017

This study suggested a positive association between DEHP and BBzP exposure and childhood asthma.Jul 06, 2017

Association between phthalate exposure and blood pressure during pregnancy.Nov 19, 2019

Associations between exposure to phthalates and subclinical hypothyroidism in pregnant women during early pregnancy.Jan 11, 2023

Associations of phthalates with prostate cancer among the US population.Jan 12, 2023

Associations of prenatal exposure to phthalates with measures of cognition in 7.5-month-old infants.Mar 07, 2021

Butyl-benzyl-phthalate has a critical impact on the etiology of major depressive disorder disorder in Mexican patients.Feb 01, 2022

Child exposure to phthalates may contribute to ADHD, ODD and externalizing and internalizing behaviour problems.Sep 30, 2017

Combined phthalates influence on glucose and lipid metabolism may increase the possibility for NAFLD and insulin resistance development.Dec 05, 2019

Consumer practices represent the substantial source of phthalate exposure in Slovak children.Feb 28, 2017

Cumulative risk assessment of phthalates associated with birth outcomes in pregnant Chinese women.Feb 28, 2017

DEHP and DBP could be risk factors for asthma.Mar 31, 2017

Early life exposure to phthalates and the development of childhood asthma among Canadian children.Mar 06, 2021

Early-life DEHP exposure alter gut microbiota of newborns and may change their immune responses in later life.Jul 25, 2019

Early-life phthalate exposure was found to be associated with the behavioural characteristics of children.Jan 09, 2020

Exposure to Bisphenol A and phthalates metabolites in the third trimester of pregnancy and BMI trajectories.Apr 25, 2018

Exposure to bisphenols and phthalates is associated with oxidant stress, insulin resistance, and endothelial dysfunction in children.May 31, 2017

Exposure to certain phthalates may cause the placenta to become thicker and more circular.Oct 09, 2017

Exposure to environmental phthalates have the potential to alter circulating levels of thyroid hormones in pregnant women.Oct 31, 2016

Exposure to phthalates and bisphenol A is associated with higher risk of cardiometabolic impairment in normal weight children.May 03, 2019

Exposure to phthalates may possibly impair control of blood glucose and thereby predispose to pre-diabetes.Jan 14, 2018

Exposure to some phthalates at 5-7 years of age might interfere with thyroid hormones and growth.Nov 20, 2016

Fetal exposure to bisphenols and phthalates and childhood bone mass.Jun 30, 2020

High levels of prenatal exposure to phthalates are significantly associated with decreased skeletal muscle index among girls.Dec 11, 2019

High-level dibutyl phthalate exposure was associated with an approximately two-fold increase in the rate of estrogen receptor-positive breast cancer.Apr 16, 2019

High-temperature soup foods in plastic packaging are associated with phthalate body burden and expression of inflammatory mRNAs.Jun 20, 2022

Induced perspiration may be useful to facilitate elimination of some potentially toxic phthalate compounds including DEHP and MEHP.Dec 31, 2011

Internal body concentrations of endocrine disrupting chemicals are associated with an increased risk of subfertility together with alterations in hormone levels.Aug 16, 2015

Maternal bisphenol and phthalate urine concentrations and weight gain during pregnancy.Dec 17, 2019

Maternal phthalate and bisphenol urine concentrations during pregnancy and early markers of arterial health in children.Dec 31, 2021

MEHP exposure was concurrently associated with lower testosterone levels in young, male adults.Mar 26, 2017

Micromolar sums of the oxidative metabolites of DEHP were all significantly related to diabetes mellitus in males.Jun 04, 2017

Mono-(2-ethylhexyl) phthalate promotes dengue virus infection by decreasing IL-23-mediated antiviral responses.Dec 31, 2020

Monocarboxyisooctyl phthalate was associated with lower respiratory health after controlling for related chemical exposureOct 17, 2018

Nail technicians are occupationally exposed to certain phthalates, phthalate alternatives, and organophosphate esters.Dec 16, 2019

Occurrence of eczema in early childhood may be influenced by prenatal exposure to certain phthalates in boys.Feb 01, 2018

Phthalate exposure and neurodevelopmental outcomes in early school age children from Poland.Nov 30, 2019

Phthalate exposure enhances incidence of urinary incontinence.Apr 26, 2022

Phthalate exposure increased the risk of early renal impairment in Taiwanese without type 2 diabetes mellitus.Nov 25, 2019

Phthalate exposure were associated with prostate cancer occurrence in abdominally obese men.Nov 07, 2019

Phthalate exposures and MicroRNA expression in uterine fibroids.Dec 31, 2019

Prenatal concentrations of certain phthalates and outcomes at birth were modestly associated with molecular changes in fetal placental tissue during pregnancy.Apr 04, 2017

Relationships among phthalate exposure, oxidative stress, and insulin resistance in young military soldiers.May 22, 2022

The effects of phthalate exposure on metabolic parameters in polycystic ovary syndrome.Jan 06, 2023

The phthalate exposure in the first trimester might be associated with the fasting blood glucose level in the third trimesterMar 09, 2017

The present study suggests that dimethyl phthalate exposure increases the risk of high blood pressure.Jul 16, 2020

The role of Di(2-ethylhexyl) phthalate as an exacerbating factor in chronic spontaneous urticaria.Apr 30, 2022

There was an association between total phthalate concentration and non-communicable diseases and chronic inflammation in men.Jul 03, 2017

These results also suggested that serum levels of phthalate metabolites are a good predictor for male infertility.Jul 10, 2020

These results are consistent with the hypothesis that exposure to phthalates influences thyroid function and growth hormone homeostasis.Jan 31, 2017

These results may provide evidence for the hypothesis that reductions in thyroid hormones mediate associations between early life phthalate exposures.Aug 31, 2017

This study reveals a more elevated occupational intake of phthalate and non-phthalate plasticizers through the indoor dust at salons than at homes.Jul 16, 2017

Time course of phthalate cumulative risks to male developmental health over a 27-year period.Feb 04, 2020

Ultra-processed food consumption may increase exposure to currently used phthalates.Jan 09, 2019

Urinary phthalate exposures and risk of breast cancer: the Multiethnic Cohort study.Apr 05, 2021

β-carotene could protect against di-2-ethylhexyl phthalate induced insulin resistance.Oct 31, 2019

The present study demonstrates preliminary information regarding the low dose proliferative effects of phthalates in prostate cancer in vitro.Dec 31, 2016

Bisphenol A and Di(2-Ethylhexyl) Phthalate promote pulmonary carcinoma.Jan 14, 2023

Administration of celery oil protected the testis against DEHP induced toxicity.Aug 31, 2014

Antoxidants can protect the testes from phthalate induced toxicity. Apr 01, 2000

Ascorbic acid ameliorates dysregulated folliculogenesis induced by mono-(2-ethylhexyl)phthalate in neonatal mouse ovaries.Aug 02, 2020

Celery oil seed extract ameliorated the toxicological effects of DEHP in rats.Mar 31, 2015

Curcumin (from Turmeric) and kolaviron (a compound from the seeds of Garcinia kola) ameliorate phthalate-induced testicular damage in rats. Jan 01, 2007

Curcumin and resveratrol may be useful potential agents in combating DEHP-induced testicular dysfunction.Sep 07, 2015

Curcumin decreases dibutyl phthalate-induced renal dysfunction in Kunming mice via inhibiting oxidative stress and apoptosis.Mar 16, 2021

Curcumin suppressed phthalate-induced cell migration, invasion and epithelial-mesenchymal transition, decreased the proportion of CSC-like cells.Nov 19, 2015

Di-(2-ethylhexyl) phthalate aggravates fine particulate matter-induced asthma.Jan 14, 2023

Di-(2-ethylhexyl) phthalate exposure impairs cortical development in hESC-derived cerebral organoids.Dec 28, 2022

Di-(2-ethylhexyl) phthalate exposure induces female reproductive toxicity.Mar 03, 2021

Di-2-ethylhexyl phthalate (DEHP) induced lipid metabolism disorder in liver.May 06, 2022

Di-2-ethylhexyl phthalate imposes acute and profound damage to spermatozoaDec 31, 2019

Phthalate Toxicity

View the Evidence:
144 Abstracts with Phthalate Toxicity Research