Pulmonary Fibrosis

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53 Substances Researched for Pulmonary Fibrosis
NameACCKFocus
Curcumin1325Locked
Ginkgo biloba314Locked
Fiber110Locked
Fruit: All110Locked
Sulforaphane110Locked
Resveratrol47Locked
Fish Oil24Locked
Taurine24Locked
EGCG (Epigallocatechin gallate)23Locked
NAC (N-acetyl-L-cysteine)23Locked
Alpha-Lipoic Acid12Locked
Angelica12Locked
Beta Sitosterol12Locked
Biochanin A12Locked
Borage Oil12Locked
Carnitine12Locked
Chinese Herbal Formula: Decoction for Strengthening Qi and Replenishing Lung (DSQRL)12Locked
Cordyceps sinensis12Locked
Corn Silk12Locked
EPA (Eicosapentaenoic Acid)12Locked
Flavonoids12Locked
Garlic12Locked
Grape Seed Extract12Locked
Gymnadenia conopsea12Locked
Honokiol12Locked
Hu Zhang (Polygonum cuspidatum)12Locked
Kaempferol12Locked
Lecithin12Locked
Mangiferin12Locked
Naringenin 12Locked
Niacin12Locked
Orange: Mandarin12Locked
Panax Notoginseng12Locked
Pterostilbene12Locked
Quercetin12Locked
Red Sage22Locked
St. Johns Wort12Locked
Superoxide dismutase12Locked
Tanshinone IIA22Locked
Thymoquinone12Locked
Vitamin D12Locked
Vitamin E12Locked
Arctigenin11Locked
Artesunate11Locked
Astaxanthin11Locked
Astragaloside11Locked
Berberine11Locked
Catechin 11Locked
Green Tea11Locked
Ligusticum wallichii 11Locked
Melatonin11Locked
Puerarin11Locked
Salvia miltiorrhiza11Locked
4 Problem Substances Researched for Pulmonary Fibrosis
NameACCKFocus
Paraquat34Locked
Electronic Cigarettes12Locked
Perchlorate12Locked
Pesticides12Locked
7 Therapeutic Actions Researched for Pulmonary Fibrosis
NameACCKFocus
Exercise: Aerobic120Locked
Therapeutic Breathing120Locked
Dietary Modification: Low Fat Diet110Locked
Dietary Modification: Vegetarian110Locked
Exercise: Inspiratory Muscle Training110Locked
Moxibustion110Locked
Laser Treatment: Low-Level12Locked
2 Problematic Actions Researched for Pulmonary Fibrosis
NameACCKFocus
Vaccination: All13Locked
Vaccination: Influenza13Locked

View the Evidence:
88 Abstracts with Pulmonary Fibrosis Research

[+]

Breathing exercises complements exercise training towards improved dyspnea and health-related quality of life in patients with Idiopathic pulmonary fibrosis.Feb 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Thorac Dis. 2020 Mar ;12(3):1041-1055. PMID: 32274173
Article Published Date : Feb 29, 2020
Study Type : Meta Analysis, Review
Additional Links
Diseases : Pulmonary Fibrosis
Therapeutic Actions : Exercise: Aerobic, Therapeutic Breathing
[+]

Adding inspiratory muscle training increases effectiveness of pulmonary rehabilitation in idiopathic pulmonary fibrosis patients.Jan 01, 2008

Pubmed Data : Pneumonol Alergol Pol. 2008;76(3):131-41. PMID: 18843927
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Diseases : Pulmonary Fibrosis
Therapeutic Actions : Exercise: Inspiratory Muscle Training
[+]

Dietary fat and meat intake are correlated with increased risk for idiopathic pulmonary fibrosis. Mar 01, 2006

Pubmed Data : Int J Tuberc Lung Dis. 2006 Mar;10(3):333-9. PMID: 16562716
Article Published Date : Mar 01, 2006
Study Type : Human Study
Additional Links
Diseases : Pulmonary Fibrosis
Therapeutic Actions : Dietary Modification: Low Fat Diet, Dietary Modification: Vegetarian
[+]

Ginkgo is effective in treating pulmonary interstitial fibrosis.Mar 01, 2005

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005 Mar;25(3):222-4. PMID: 15842142
Article Published Date : Mar 01, 2005
Study Type : Human Study
Additional Links
Substances : Ginkgo biloba
Diseases : Interstitial Lung Diseases, Pulmonary Fibrosis
Pharmacological Actions : Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Natural Substances Versus Drugs
[+]

Moxibustion can significantly suppress the expression of TGF-beta1mRNA in the pulmonary tissue in the rat of bleomycin-induced pulmonary fibrosis.Nov 01, 2005

Pubmed Data : Zhongguo Zhen Jiu. 2005 Nov;25(11):790-2. PMID: 16335208
Article Published Date : Nov 01, 2005
Study Type : Human Study
Additional Links
Diseases : Pulmonary Fibrosis
Therapeutic Actions : Moxibustion
Pharmacological Actions : Transforming growth factor beta (TGF-β) inhibitor
[+]

NAC could ameliorate COPD-induced pulmonary fibrosis by promoting immune response.Jan 02, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med. 2021 09 3 ;27(1):97. Epub 2021 Sep 3. PMID: 34479474
Article Published Date : Jan 02, 2021
Study Type : Human Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Chronic Obstructive Pulmonary Disease, Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Immunomodulatory
[+]

Oral sulforaphane safely and effectively induces mucosal Phase II enzyme expression in the upper airway of human subjects. Mar 01, 2009

Pubmed Data : Clin Immunol. 2009 Mar;130(3):244-51. Epub 2008 Nov 22. PMID: 19028145
Article Published Date : Mar 01, 2009
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : COPD, Cystic Fibrosis, Glutathione Deficiency , Lung Diseases, Pulmonary Fibrosis, Respiratory Diseases
Pharmacological Actions : Antioxidants, Glutathione Upregulation , Phase II Detoxification Enzyme Inducer
Additional Keywords : Isothiocyanates
[+]

Pycnogenol®-Centellicum® supplementation improves lung fibrosis and Post-Covid-19 lung healing.Jun 27, 2021

Pubmed Data : Minerva Med. 2021 Jun 28. Epub 2021 Jun 28. PMID: 34180638
Article Published Date : Jun 27, 2021
Study Type : Human Study
Additional Links
Substances : Pycnogenol (Pine Bark)
Diseases : Coronavirus Infection, Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Soluble fiber and fruit intake may confer protection against the development of idiopathic pulmonary fibrosis (IPF).Nov 01, 2004

Pubmed Data : Ann Nutr Metab. 2004 Nov-Dec;48(6):390-7. Epub 2004 Nov 30. PMID: 15583467
Article Published Date : Nov 01, 2004
Study Type : Human Study
Additional Links
Substances : Fiber, Fruit: All
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Antioxidants
Additional Keywords : Risk Reduction
[+]

A case report of idiopathic pulmonary fibrosis after the H1N1 influenza vaccine.Jan 01, 2010

Pubmed Data : Intern Med. 2010 ;49(21):2333-6. Epub 2010 Nov 1. PMID: 21048370
Article Published Date : Jan 01, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Pulmonary Fibrosis
Anti Therapeutic Actions : Vaccination: All, Vaccination: Influenza
[+]

Alpha lipoic acid attenuates bleomycin-induced pulmonary fibrosis in mice. Jun 01, 2007

Pubmed Data : Int J Mol Med. 2007 Jun;19(6):865-73. PMID: 17487418
Article Published Date : Jun 01, 2007
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
[+]

An extract of Mandarin Orange demonstrates anti-pulmonary fibrosis effects. Oct 29, 2009

Pubmed Data : J Ethnopharmacol. 2009 Oct 29;126(1):143-8. Epub 2009 Jul 28. PMID: 19643175
Article Published Date : Oct 29, 2009
Study Type : Animal Study
Additional Links
Substances : Orange: Mandarin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
[+]

Angelica sinesis inhibits the progress of radiation-induced pulmonary fibrosis. Mar 01, 2007

Pubmed Data : Zhonghua Yu Fang Yi Xue Za Zhi. 2007 Mar;41(2):105-9. PMID: 17605235
Article Published Date : Mar 01, 2007
Study Type : Animal Study
Additional Links
Substances : Angelica
Diseases : Pulmonary Fibrosis, Radiation Induced Illness: Thoracic
[+]

Beta-sitosterol can be used to attenuate pulmonary fibrosis through suppression of EMT by inhibiting the TGF-β1/Snail pathway.Sep 03, 2019

Pubmed Data : J Agric Food Chem. 2019 Sep 4 ;67(35):9789-9795. Epub 2019 Aug 19. PMID: 31373816
Article Published Date : Sep 03, 2019
Study Type : Animal Study
Additional Links
Substances : Beta Sitosterol, Corn Silk
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor
Additional Keywords : Plant Extracts
[+]

Biochanin-A ameliorates pulmonary fibrosis.Jul 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Phytomedicine. 2020 Aug 1 ;78:153298. Epub 2020 Aug 1. PMID: 32781391
Article Published Date : Jul 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor
[+]

Cigarette smoke exposure combined with lipopolysaccharides induced pulmonary fibrosis in mice.Jul 31, 2019

Pubmed Data : Respir Physiol Neurobiol. 2019 Aug ;266:9-17. Epub 2019 Apr 22. PMID: 31022471
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Diseases : Lipopolysaccharide-Induced Toxicity, Pulmonary Fibrosis
Problem Substances : Electronic Cigarettes
[+]

Cordyceps alleviates bleomycin-induced alveolitis and fibrosis. Dec 01, 2007

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2007 Dec;32(24):2623-7. PMID: 18338602
Article Published Date : Dec 01, 2007
Study Type : Animal Study
Additional Links
Substances : Cordyceps sinensis
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
[+]

Curcumin (from Turmeric) reduces oxidative injury associated with idiopathic pulmonary fibrosis.Apr 01, 2006

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2006 Apr;31(8):669-72. PMID: 16830828
Article Published Date : Apr 01, 2006
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Pulmonary Fibrosis
[+]

Curcumin can alleviate alveolitis and pulmonary fibrosis induced by bleomycin in rats.Mar 01, 2007

Pubmed Data : Zhonghua Jie He He Hu Xi Za Zhi. 2007 Mar;30(3):197-201. PMID: 17572999
Article Published Date : Mar 01, 2007
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Alveolitis: Fibrosing, Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
[+]

Curcumin can induce apoptosis of pulmonary fibroblasts in rats with bleomycin-induced pulmonary fibrosis.Jan 01, 2009

Pubmed Data : Zhonghua Jie He He Hu Xi Za Zhi. 2009 Jan;32(1):37-41. PMID: 19484960
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Apoptotic
[+]

Curcumin has a similar effect to hydrocortisone in preventing bleomycin-induced pulmonary fibrosis. Jun 13, 2007

Pubmed Data : J Ethnopharmacol. 2007 Jun 13;112(2):292-9. Epub 2007 Mar 13. PMID: 17434272
Article Published Date : Jun 13, 2007
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Curcumin inhibits bleomycin-induced pulmonary fibrosis in rats.Sep 01, 2000

Pubmed Data : Br J Pharmacol. 2000 Sep;131(2):169-72. PMID: 10991907
Article Published Date : Sep 01, 2000
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Pharmacological Actions : Anti-Bacterial Agents
[+]

Curcumin inhibits fibrosis-related effects in IPF fibroblasts and in mice following bleomycin-induced lung injury.Jan 08, 2010

Pubmed Data : Am J Physiol Lung Cell Mol Physiol. 2010 Jan 8. Epub 2010 Jan 8. PMID: 20061443
Article Published Date : Jan 08, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Pharmacological Actions : Transforming growth factor beta (TGF-β) inhibitor
Additional Keywords : Drug Side Effect Attenuation
[+]

Curcumin is more effective than prednisone at suppressing bleomycin-induced pulmonary fibrosis in rats. May 01, 2008

Pubmed Data : Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2008 May;26(5):257-61. PMID: 18727865
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Pharmacological Actions : Transforming growth factor beta (TGF-β) inhibitor
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Curcumin may play its therapetuic role by leveling down the content of extracellular matrix in rats with pulmonary fibrosis induced by bleomycin.Apr 01, 2006

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2006 Apr;31(7):570-3. PMID: 16780161
Article Published Date : Apr 01, 2006
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
[+]

Curcumin protects against amiodarone-induced pulmonary fibrosis in rats.Aug 01, 2003

Pubmed Data : Br J Pharmacol. 2003 Aug;139(7):1342-50. PMID: 12890714
Article Published Date : Aug 01, 2003
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin protects against bleomycin-induced damages in pulmonary functions in ratsJun 01, 2008

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2008 Jun;33(12):1434-8. PMID: 18837350
Article Published Date : Jun 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
[+]

Curcumin was beneficial in acute lung injury and lung fibrosis.Aug 22, 2019

Pubmed Data : Endocr Metab Immune Disord Drug Targets. 2019 Aug 23. Epub 2019 Aug 23. PMID: 31441735
Article Published Date : Aug 22, 2019
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Lung Injury: Acute, Pulmonary Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic
[+]

Diallyl sulfide reduced the bleomycin-induced activation of inducible nitric oxide synthase (iNOS) and nuclear factor kappa-B (NF-kappaB) and decreased the augmented levels of the early inflammatory cytokines, tumour necrosis factor-alpha (TNF-alpha) and Jun 06, 2008

Pubmed Data : Life Sci. 2008 Jun 6;82(23-24):1142-53. Epub 2008 Apr 4. PMID: 18462759
Article Published Date : Jun 06, 2008
Study Type : Animal Study
Additional Links
Substances : Garlic
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice.May 01, 2010

Pubmed Data : Radiat Res. 2010 May;173(5):590-601. PMID: 20426658
Article Published Date : May 01, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Lung Cancer, Pulmonary Fibrosis, Radiation Induced Illness
Pharmacological Actions : Antioxidants, Radioprotective
[+]

Dietary fish oil and fish and borage oil suppress intrapulmonary inflammation and attenuate pulmonary neutrophil accumulation in endotoxic rats.Jul 01, 1997

Pubmed Data : Crit Care Med. 1997 Jul;25(7):1198-206. PMID: 9233748
Article Published Date : Jul 01, 1997
Study Type : Animal Study
Additional Links
Substances : Borage Oil, EPA (Eicosapentaenoic Acid), Fish Oil
Diseases : Endotoxemia, Pulmonary Fibrosis
[+]

EGCG exhibits anti-fibrotic effects in a rat model of pulmonary fibrosis. Jul 15, 2009

Pubmed Data : Chem Biol Interact. 2009 Jul 15;180(2):271-80. Epub 2009 Mar 20. PMID: 19497426
Article Published Date : Jul 15, 2009
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
[+]

Ferulic acid combined with astragaloside IV reduced the degree of pulmonary fibrosis.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:8845798. Epub 2021 Mar 2. PMID: 33763150
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Astragaloside, Ferulic acid
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic
Additional Keywords : Natural Substance Synergy
[+]

Fish oil protects against inflammation and fibrosis in the lung and liver. Jun 14, 2002

Pubmed Data : Toxicology. 2002 Jun 14;175(1-3):1-13. PMID: 12049831
Article Published Date : Jun 14, 2002
Study Type : Animal Study
Additional Links
Substances : Fish Oil
Diseases : Liver Fibrosis, Pulmonary Fibrosis
[+]

Galangin ameliorated pulmonary fibrosis in vivo and in vitro by regulating epithelial-mesenchymal transition.Sep 30, 2020

Pubmed Data : Bioorg Med Chem. 2020 Oct 1 ;28(19):115663. Epub 2020 Jul 28. PMID: 32912432
Article Published Date : Sep 30, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Ginkgo biloba has a positive effect on pulmonary interstitial fibrosis in ratsJun 01, 2000

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000 Jun;20(6):441-3. PMID: 11789230
Article Published Date : Jun 01, 2000
Study Type : Animal Study
Additional Links
Substances : Ginkgo biloba
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Pharmacological Actions : NF-kappaB Inhibitor, Transforming growth factor beta (TGF-β) inhibitor
[+]

Grape seed extract attenuates silica-induced pulmonary fibrosis in rats. Aug 01, 2009

Pubmed Data : Reproduction. 2009 Aug;138(2):279-87. Epub 2009 Jun 3. PMID: 18547852
Article Published Date : Aug 01, 2009
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Pulmonary Fibrosis
[+]

Gymnadenia conopsea can ameliorate the silica-induced pulmonary fibrosis by increasing the activities of antioxidase and alleviating the damage of lipid peroxidation to the lungs.Jan 01, 2007

Pubmed Data : Zhong Xi Yi Jie He Xue Bao. 2007 Jan;5(1):50-5. PMID: 17214936
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Substances : Gymnadenia conopsea
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts
[+]

Honokiol ameliorates pulmonary fibrosis.Feb 03, 2020

Pubmed Data : Toxicol Appl Pharmacol. 2020 Feb 4:114913. Epub 2020 Feb 4. PMID: 32032644
Article Published Date : Feb 03, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Honokiol
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation
[+]

Hu Zhang (Polygonum cuspidatum), a rich source of resveratrol, inhibits the expression of inflammation in lung fibroblasts and reduces alveolitis and pulmonary fibrosis. Jun 01, 2009

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2009 Jun;34(12):1574-7. PMID: 19777850
Article Published Date : Jun 01, 2009
Study Type : Animal Study
Additional Links
Substances : Hu Zhang (Polygonum cuspidatum), Resveratrol
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]

Hyperforin, a compound found within St. John's wort, has powerful anti-inflammatory therapeutic potential in reducing lung fibrosis. May 01, 2007

Pubmed Data : J Pharmacol Exp Ther. 2007 May;321(2):492-500. Epub 2007 Feb 8. PMID: 17289834
Article Published Date : May 01, 2007
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Cystic Fibrosis, Pulmonary Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]

Kaempferol inhibits the progression of silica-induced pulmonary fibrosis.Sep 26, 2019

Pubmed Data : DNA Cell Biol. 2019 Sep 27. Epub 2019 Sep 27. PMID: 31560574
Article Published Date : Sep 26, 2019
Study Type : Animal Study
Additional Links
Substances : Kaempferol
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

L-carnitine and ginkgo biloba extract exhibits a protective agent in an animal model of bleomycin-induced lung fibrosis Jun 01, 2002

Pubmed Data : Pharmacol Res. 2002 Jun;45(6):461-7. PMID: 12162946
Article Published Date : Jun 01, 2002
Study Type : Animal Study
Additional Links
Substances : Carnitine, Ginkgo biloba
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Lecithinized superoxide dismutase has protective activity against bleomycin-induced pulmonary fibrosis. Dec 24, 2009

Pubmed Data : Am J Physiol Lung Cell Mol Physiol. 2009 Dec 24. Epub 2009 Dec 24. PMID: 20034962
Article Published Date : Dec 24, 2009
Study Type : Animal Study
Additional Links
Substances : Lecithin, Superoxide dismutase
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Additional Keywords : Drug Side Effect Attenuation
[+]

Low-level laser therapy attenuates lung inflammation and airway remodeling in a murine model of idiopathic pulmonary fibrosis.Dec 31, 2019

Pubmed Data : J Photochem Photobiol B. 2020 Jan ;203:111731. Epub 2019 Dec 4. PMID: 31935633
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Diseases : Lung Inflammation, Pulmonary Fibrosis
Therapeutic Actions : Laser Treatment: Low-Level
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

N-acetylcysteine therapeutically protects against pulmonary fibrosis in a mouse model of silicosis.Jul 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biosci Rep. 2019 Jul 31 ;39(7). Epub 2019 Jul 18. PMID: 31273057
Article Published Date : Jul 30, 2019
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Pulmonary Fibrosis, Silicosis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Naringenin significantly reduces lung metastases in mice with pulmonary fibrosis and increases their survival by improving immune function. Apr 01, 2009

Pubmed Data : Cancer Res. 2009 Apr 1;69(7):3205-12. Epub 2009 Mar 24. PMID: 19318568
Article Published Date : Apr 01, 2009
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Lung Cancer, Pulmonary Fibrosis
[+]

Niacin could effectively attenuate the over expression of nitric oxide synthase in the rat lung induced by silica particles. May 01, 2004

Pubmed Data : Zhonghua Yu Fang Yi Xue Za Zhi. 2004 May;38(3):186-9. PMID: 15182488
Article Published Date : May 01, 2004
Study Type : Animal Study
Additional Links
Substances : Niacin
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Nitric Oxide Inhibitor
[+]

Panax notoginside compares favorably with methylprednisolone in a rat model of pulmonary fibrosisSep 01, 2002

Pubmed Data : Zhonghua Jie He He Hu Xi Za Zhi. 2002 Sep;25(9):520-3. PMID: 12423557
Article Published Date : Sep 01, 2002
Study Type : Animal Study
Additional Links
Substances : Panax Notoginseng
Diseases : Pulmonary Fibrosis
Additional Keywords : Natural Substances Versus Drugs
[+]

Paraquat induces pulmonary fibrosis through Wnt/β-catenin signaling pathway and myofibroblast differentiation.Oct 14, 2020

Pubmed Data : Toxicol Lett. 2020 Oct 15 ;333:170-183. Epub 2020 Aug 11. PMID: 32795487
Article Published Date : Oct 14, 2020
Study Type : Animal Study
Additional Links
Diseases : Herbicide Toxicity, Pulmonary Fibrosis
Problem Substances : Paraquat
[+]

Perchlorate can induce pulmonary fibrosis in the rabbit lung.Oct 12, 2010

Pubmed Data : Toxicol Ind Health. 2010 Oct 12. Epub 2010 Oct 12. PMID: 20937628
Article Published Date : Oct 12, 2010
Study Type : Animal Study
Additional Links
Diseases : Pulmonary Fibrosis
Problem Substances : Perchlorate
Adverse Pharmacological Actions : Inflammatory
[+]

Pterostilbene prevents LPS-induced early pulmonary fibrosis by suppressing oxidative stress, inflammation and apoptosis in vivo.May 06, 2020

Pubmed Data : Food Funct. 2020 May 7. Epub 2020 May 7. PMID: 32377661
Article Published Date : May 06, 2020
Study Type : Animal Study
Additional Links
Substances : Pterostilbene
Diseases : Lipopolysaccharide-Induced Toxicity, Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Resveratrol alleviates chemotherapy-induced (bleomycin) lung injury in rats. Jan 01, 2007

Pubmed Data : : Pulm Pharmacol Ther. 2007;20(6):642-9. Epub 2006 Sep 3. PMID: 17035056
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Chemotherapy-Induced Toxicity, Chemotherapy-Induced Toxicity: Adriamycin, Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Role of the Hippo signaling pathway in safflower yellow pigment treatment of paraquat-induced pulmonary fibrosis.Aug 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Int Med Res. 2020 Sep ;48(9):300060520905425. PMID: 32940100
Article Published Date : Aug 31, 2020
Study Type : Animal Study
Additional Links
Substances : Safflower
Diseases : Paraquat Toxicity, Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic
Problem Substances : Paraquat
[+]

Taurine can effectively attenuate type I and III collagen expression in the rat lung induced by silica particles. Sep 01, 2006

Pubmed Data : Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 Sep;24(9):544-6. PMID: 17034730
Article Published Date : Sep 01, 2006
Study Type : Animal Study
Additional Links
Substances : Taurine
Diseases : Pulmonary Fibrosis
[+]

The Chinese medicine DSQRL is superior to prednisone in treating experimental pulmonary fibrosis. Mar 05, 2008

Pubmed Data : J Ethnopharmacol. 2008 Mar 5;116(2):318-24. Epub 2007 Dec 4. PMID: 18191351
Article Published Date : Mar 05, 2008
Study Type : Animal Study
Additional Links
Substances : Chinese Herbal Formula: Decoction for Strengthening Qi and Replenishing Lung (DSQRL)
Diseases : Pulmonary Fibrosis
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

These findings confirmed the anti-inflammatory effects of resveratrol and quercetin in BLM-induced lung damage.Aug 31, 2015

Pubmed Data : Br J Nutr. 2015 Sep ;114(6):853-865. PMID: 26334388
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Substances : Mangiferin, Quercetin, Resveratrol
Diseases : Pulmonary Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

These results showed engeletin remedies pulmonary fibrogenesis.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2020 Dec ;58(1):1105-1114. PMID: 33181025
Article Published Date : Nov 30, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Thymoquinone has the preventive and therapeutic potentials for the treatment of lung fibrosis.Jun 17, 2016

Pubmed Data : Environ Toxicol Pharmacol. 2016 Jun 18 ;45:340-345. Epub 2016 Jun 18. PMID: 27375216
Article Published Date : Jun 17, 2016
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Antioxidants
Additional Keywords : Gene Expression Regulation
Problem Substances : Pesticides
[+]

Treatment with taurine can effectively attenuate the pathological expression of TNF-alpha protein of lung in rats induced by silica.May 01, 2007

Pubmed Data : Wei Sheng Yan Jiu. 2007 May;36(3):364-6. PMID: 17712964
Article Published Date : May 01, 2007
Study Type : Animal Study
Additional Links
Substances : Taurine
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Vitamin D prevents experimental lung fibrosis and predicts survival in patients with idiopathic pulmonary fibrosis.Dec 31, 2018

Pubmed Data : Pulm Pharmacol Ther. 2019 04 ;55:17-24. Epub 2019 Jan 16. PMID: 30659895
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Vitamin D
Diseases : Pulmonary Fibrosis, Vitamin D Deficiency
Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator
[+]

Vtamin E is superior to pentoxifylline in protecting against radiation-induced pulmonary fibrosis in rats. May 01, 2007

Pubmed Data : Clin Oncol (R Coll Radiol). 2007 May;19(4):260-4. Epub 2007 Jan 12. PMID: 17433970
Article Published Date : May 01, 2007
Study Type : Animal Study
Additional Links
Substances : Vitamin E
Diseases : Pulmonary Fibrosis, Radiation Induced Illness: Thoracic
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

The herbicide paraquat-induced molecular mechanisms in the development of acute lung injury and lung fibrosis.Dec 31, 2020

Pubmed Data : Crit Rev Toxicol. 2021 Jan ;51(1):36-64. Epub 2021 Feb 2. PMID: 33528289
Article Published Date : Dec 31, 2020
Study Type : Review
Additional Links
Diseases : Herbicide Toxicity, Lung Injury: Acute, Pulmonary Fibrosis
[+]

A fundamental treatment goal of pulmonary fibrosis is alhpa(v)beta6-mediated Transforming growth factor (TGF)-beta suppression. Jan 01, 2008

Pubmed Data : Am J Respir Crit Care Med. 2008 Jan 1;177(1):56-65. Epub 2007 Oct 4. PMID: 17916809
Article Published Date : Jan 01, 2008
Study Type : Commentary
Additional Links
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Transforming growth factor beta (TGF-β) inhibitor
[+]

A review of carnosine and lung disease.Jul 11, 2019

Pubmed Data : Curr Med Chem. 2019 Jul 12. Epub 2019 Jul 12. PMID: 31309876
Article Published Date : Jul 11, 2019
Study Type : Review
Additional Links
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Diseases, Oxidative Stress, Pulmonary Fibrosis
Pharmacological Actions : Antioxidants
[+]

Arctigenin suppressed epithelial-mesenchymal transition through Wnt3a/β-catenin pathway in PQ-Induced pulmonary fibrosis Dec 31, 2019

Pubmed Data : Front Pharmacol. 2020 ;11:584098. Epub 2020 Dec 16. PMID: 33390951
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Arctigenin
Diseases : Pesticide Toxicity , Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic
Problem Substances : Paraquat
[+]

Artesunate restraining MAPK passage by smad7 to resist pulmonary fibrosis.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur Rev Med Pharmacol Sci. 2014 ;18(21):3199-204. PMID: 25487928
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Artesunate
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Astaxanthin attenuates pulmonary fibrosis through lncITPF and mitochondria‐mediated signal pathways.Aug 18, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2020 Aug 19. Epub 2020 Aug 19. PMID: 32813323
Article Published Date : Aug 18, 2020
Study Type : In Vitro Study
Additional Links
Substances : Astaxanthin
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Astragaloside IV alleviates silica‑induced pulmonary fibrosis.Feb 28, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2021 Mar ;47(3). Epub 2021 Jan 15. PMID: 33448318
Article Published Date : Feb 28, 2021
Study Type : In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Pulmonary Fibrosis, Silicosis
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor
[+]

Astragaloside IV attenuates TGF-β-mediated epithelial-mesenchymal transition of pulmonary fibrosis.Feb 24, 2021

Pubmed Data : Pharmazie. 2021 Feb 25 ;76(2):97-102. PMID: 33714286
Article Published Date : Feb 24, 2021
Study Type : In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Combination therapy of tanshinone IIA and puerarin for pulmonary fibrosis.Aug 23, 2021

Pubmed Data : Phytother Res. 2021 Aug 24. Epub 2021 Aug 24. PMID: 34427348
Article Published Date : Aug 23, 2021
Study Type : In Vitro Study
Additional Links
Substances : Puerarin, Tanshinone IIA
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation
[+]

Curcumin not only could inhibit TGF-β2 induced proliferation of lung fibroblasts, but also could inhibit the synthesis of collagens.Sep 30, 2015

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2015 Oct ;35(10):1249-54. PMID: 26677679
Article Published Date : Sep 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Pulmonary Fibrosis
[+]

Efficacy and safety of N-acetylcysteine therapy for idiopathic pulmonary fibrosis.Jun 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2019 Jul ;18(1):802-816. Epub 2019 May 15. PMID: 31258714
Article Published Date : Jun 30, 2019
Study Type : Review
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

EGCG inhibits neutrophil-associated damage in a pulmonary inflammation model, significantly reducing fibrosis. Apr 15, 2003

Pubmed Data : J Immunol. 2003 Apr 15;170(8):4335-41. PMID: 12682270
Article Published Date : Apr 15, 2003
Study Type : Review
Additional Links
Substances : Catechin , EGCG (Epigallocatechin gallate), Green Tea
Diseases : Inflammation, Pulmonary Fibrosis
Pharmacological Actions : Anti-Angiogenic, Anti-Inflammatory Agents
Additional Keywords : Plant Extracts
[+]

Ginsenoside Rg3 inhibits pulmonary fibrosis by preventing HIF-1α nuclear localisation.Feb 26, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Pulm Med. 2021 Feb 27 ;21(1):70. Epub 2021 Feb 27. PMID: 33639908
Article Published Date : Feb 26, 2021
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hypoxia-inducible factor-1 (HIF-1) inhibitor
[+]

Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases.Jan 19, 2020

Pubmed Data : Chem Biol Interact. 2020 Jan 20 ;317:108947. Epub 2020 Jan 20. PMID: 31968208
Article Published Date : Jan 19, 2020
Study Type : Review
Additional Links
Substances : Berberine
Diseases : Asthma, Chronic Obstructive Pulmonary Disease, Inflammation, Lung Cancer, Pulmonary Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Ligustrazine, an alkaloid found within Ligusticum, and Red Sage (saliva m.) are more effective than hydrocortisone in reducing collagengene expression in rat pulmonary fibrosis. Jan 01, 1999

Pubmed Data : Zhonghua Jie He He Hu Xi Za Zhi. 1999 Jan;22(1):43-5. PMID: 11812356
Article Published Date : Jan 01, 1999
Study Type : In Vitro Study
Additional Links
Substances : Ligusticum wallichii , Red Sage
Diseases : Pulmonary Fibrosis
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Nimbolide as a potent anti-fibrotic agent.Sep 30, 2019

Pubmed Data : Int Immunopharmacol. 2019 Oct ;75:105755. Epub 2019 Aug 1. PMID: 31377591
Article Published Date : Sep 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Pulmonary Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Progress in the study of pulmonary fibrosis signaling pathways caused by paraquat poisoning.Feb 28, 2021

Pubmed Data : Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2021 Mar ;33(3):377-380. PMID: 33834986
Article Published Date : Feb 28, 2021
Study Type : Review
Additional Links
Diseases : Herbicide Toxicity, Pulmonary Fibrosis
Problem Substances : Paraquat
[+]

Pterostilbene alleviates pulmonary fibrosis by regulating ASIC2.Jul 27, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Chin Med. 2021 Jul 28 ;16(1):66. Epub 2021 Jul 28. PMID: 34321072
Article Published Date : Jul 27, 2021
Study Type : In Vitro Study
Additional Links
Substances : Pterostilbene
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic
[+]

Puerarin regulated the proliferation and apoptosis of pulmonary fibrosis cells.Aug 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2019 Aug 31 ;25:6523-6531. Epub 2019 Aug 31. PMID: 31471534
Article Published Date : Aug 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Puerarin
Diseases : Acute Respiratory Distress Syndrome, Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Interleukin-2 Downregulation, Interleukin-4 downregulation, Transforming growth factor beta (TGF-β) inhibitor
[+]

Resveratrol may have therapeutic value in pulmonary fibrosis. Jan 26, 2011

Pubmed Data : Exp Lung Res. 2011 Jan 26. Epub 2011 Jan 26. PMID: 21269063
Article Published Date : Jan 26, 2011
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Transforming growth factor beta (TGF-β) inhibitor
[+]

Review: Molecular basis of lung tissue regeneration.Apr 01, 2011

Pubmed Data : Gen Thorac Cardiovasc Surg. 2011 Apr;59(4):231-44. Epub 2011 Apr 12. PMID: 21484549
Article Published Date : Apr 01, 2011
Study Type : Review
Additional Links
Diseases : Pulmonary Fibrosis
[+]

Saikosaponin D plays an important role in anti-pulmonary fibrosis by regulating TGF-β1/Smads signalling pathway.Feb 28, 2019

Pubmed Data : Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2019 Mar ;35(3):256-261. PMID: 31030720
Article Published Date : Feb 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic
Additional Keywords : Dose Response
[+]

Salvianolic acid B and sodium tanshinone II A sulfonate prevent pulmonary fibrosis through anti-inflammatory and anti-fibrotic process.Jul 05, 2020

Pubmed Data : Eur J Pharmacol. 2020 Jul 6 ;883:173352. Epub 2020 Jul 6. PMID: 32645333
Article Published Date : Jul 05, 2020
Study Type : In Vitro Study
Additional Links
Substances : Salvia miltiorrhiza, Tanshinone IIA
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis.Dec 31, 2017

Pubmed Data : Biochem Biophys Res Commun. 2018 01 1 ;495(1):325-331. Epub 2017 Nov 4. PMID: 29108993
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Tanshinone IIA attenuates silica-induced pulmonary fibrosis.Feb 29, 2020

Pubmed Data : Chem Biol Interact. 2020 Mar 1 ;319:109024. Epub 2020 Feb 22. PMID: 32097614
Article Published Date : Feb 29, 2020
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Nrf2 activation, Transforming growth factor beta (TGF-β) inhibitor
[+]

The present study is the first to demonstrate that melatonin can protect human alveolar epithelial cells against oxidative stress.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 Dec ;132:110827. Epub 2020 Oct 13. PMID: 33065391
Article Published Date : Nov 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Lipopolysaccharide-Induced Toxicity, Pulmonary Fibrosis
Pharmacological Actions : Antioxidants, Nrf2 activation

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