Pulmonary Fibrosis

Name	AC	CK
Curcumin	13	25
Ginkgo biloba	3	14
Fiber	1	10
Fruit: All	1	10
Sulforaphane	1	10
Resveratrol	4	7
Fish Oil	2	4
Taurine	2	4
EGCG (Epigallocatechin gallate)	2	3
NAC (N-acetyl-L-cysteine)	2	3
Alpha-Lipoic Acid	1	2
Angelica	1	2
Beta Sitosterol	1	2
Biochanin A	1	2
Borage Oil	1	2
Carnitine	1	2
Chinese Herbal Formula: Decoction for Strengthening Qi and Replenishing Lung (DSQRL)	1	2
Cordyceps sinensis	1	2
Corn Silk	1	2
EPA (Eicosapentaenoic Acid)	1	2
Flavonoids	1	2
Garlic	1	2
Grape Seed Extract	1	2
Gymnadenia conopsea	1	2
Honokiol	1	2
Hu Zhang (Polygonum cuspidatum)	1	2
Kaempferol	1	2
Lecithin	1	2
Mangiferin	1	2
Naringenin	1	2
Niacin	1	2
Orange: Mandarin	1	2
Panax Notoginseng	1	2
Pterostilbene	1	2
Quercetin	1	2
Red Sage	2	2
St. Johns Wort	1	2
Superoxide dismutase	1	2
Tanshinone IIA	2	2
Thymoquinone	1	2
Vitamin D	1	2
Vitamin E	1	2
Arctigenin	1	1
Artesunate	1	1
Astaxanthin	1	1
Astragaloside	1	1
Berberine	1	1
Catechin	1	1
Green Tea	1	1
Ligusticum wallichii	1	1
Melatonin	1	1
Puerarin	1	1
Salvia miltiorrhiza	1	1

Name	AC	CK
Paraquat	3	4
Electronic Cigarettes	1	2
Perchlorate	1	2
Pesticides	1	2

Name	AC	CK
Exercise: Aerobic	1	20
Therapeutic Breathing	1	20
Dietary Modification: Low Fat Diet	1	10
Dietary Modification: Vegetarian	1	10
Exercise: Inspiratory Muscle Training	1	10
Moxibustion	1	10
Laser Treatment: Low-Level	1	2

Name	AC	CK	Focus
Vaccination: All	1	3
Vaccination: Influenza	1	3

[+]

Dietary fat and meat intake are correlated with increased risk for idiopathic pulmonary fibrosis. Mar 01, 2006

Click here to read the entire abstract

Pubmed Data : Int J Tuberc Lung Dis. 2006 Mar;10(3):333-9. PMID: 16562716

Article Published Date : Mar 01, 2006

Study Type : Human Study

Additional Links

Diseases : Pulmonary Fibrosis

Therapeutic Actions : Dietary Modification: Low Fat Diet, Dietary Modification: Vegetarian

[+]

Ginkgo is effective in treating pulmonary interstitial fibrosis.Mar 01, 2005

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005 Mar;25(3):222-4. PMID: 15842142

Article Published Date : Mar 01, 2005

Study Type : Human Study

Additional Links

Substances : Ginkgo biloba

Diseases : Interstitial Lung Diseases, Pulmonary Fibrosis

Pharmacological Actions : Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substances Versus Drugs

[+]

Moxibustion can significantly suppress the expression of TGF-beta1mRNA in the pulmonary tissue in the rat of bleomycin-induced pulmonary fibrosis.Nov 01, 2005

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhen Jiu. 2005 Nov;25(11):790-2. PMID: 16335208

Article Published Date : Nov 01, 2005

Study Type : Human Study

Additional Links

Diseases : Pulmonary Fibrosis

Therapeutic Actions : Moxibustion

Pharmacological Actions : Transforming growth factor beta (TGF-β) inhibitor

[+]

NAC could ameliorate COPD-induced pulmonary fibrosis by promoting immune response.Jan 02, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Med. 2021 09 3 ;27(1):97. Epub 2021 Sep 3. PMID: 34479474

Article Published Date : Jan 02, 2021

Study Type : Human Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Chronic Obstructive Pulmonary Disease, Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic, Immunomodulatory

[+]

Oral sulforaphane safely and effectively induces mucosal Phase II enzyme expression in the upper airway of human subjects. Mar 01, 2009

Click here to read the entire abstract

Pubmed Data : Clin Immunol. 2009 Mar;130(3):244-51. Epub 2008 Nov 22. PMID: 19028145

Article Published Date : Mar 01, 2009

Study Type : Human Study

Additional Links

Substances : Sulforaphane

Diseases : COPD, Cystic Fibrosis, Glutathione Deficiency , Lung Diseases, Pulmonary Fibrosis, Respiratory Diseases

Pharmacological Actions : Antioxidants, Glutathione Upregulation , Phase II Detoxification Enzyme Inducer

Additional Keywords : Isothiocyanates

[+]

Pycnogenol®-Centellicum® supplementation improves lung fibrosis and Post-Covid-19 lung healing.Jun 27, 2021

Click here to read the entire abstract

Pubmed Data : Minerva Med. 2021 Jun 28. Epub 2021 Jun 28. PMID: 34180638

Article Published Date : Jun 27, 2021

Study Type : Human Study

Additional Links

Substances : Pycnogenol (Pine Bark)

Diseases : Coronavirus Infection, Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic

[+]

Soluble fiber and fruit intake may confer protection against the development of idiopathic pulmonary fibrosis (IPF).Nov 01, 2004

Click here to read the entire abstract

Pubmed Data : Ann Nutr Metab. 2004 Nov-Dec;48(6):390-7. Epub 2004 Nov 30. PMID: 15583467

Article Published Date : Nov 01, 2004

Study Type : Human Study

Additional Links

Substances : Fiber, Fruit: All

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Antioxidants

Additional Keywords : Risk Reduction

[+]

A case report of idiopathic pulmonary fibrosis after the H1N1 influenza vaccine.Jan 01, 2010

Click here to read the entire abstract

Pubmed Data : Intern Med. 2010 ;49(21):2333-6. Epub 2010 Nov 1. PMID: 21048370

Article Published Date : Jan 01, 2010

Study Type : Human: Case Report

Additional Links

Diseases : Pulmonary Fibrosis

Anti Therapeutic Actions : Vaccination: All, Vaccination: Influenza

[+]

Low molecular weight fucoidan inhibits pulmonary fibrosis.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:7038834. Epub 2022 Mar 2. PMID: 35281460

Article Published Date : Dec 31, 2021

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Fucoidan

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic, Antioxidants

[+]

6-Gingerol, a functional polyphenol of ginger, reduces pulmonary fibrosis by activating Sirtuin1.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Allergol Immunopathol (Madr). 2022 ;50(2):104-114. Epub 2022 Mar 1. PMID: 35257553

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Gingerol

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic, SIRT1 Activator

[+]

Alpha lipoic acid attenuates bleomycin-induced pulmonary fibrosis in mice. Jun 01, 2007

Click here to read the entire abstract

Pubmed Data : Int J Mol Med. 2007 Jun;19(6):865-73. PMID: 17487418

Article Published Date : Jun 01, 2007

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis

[+]

An extract of Mandarin Orange demonstrates anti-pulmonary fibrosis effects. Oct 29, 2009

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2009 Oct 29;126(1):143-8. Epub 2009 Jul 28. PMID: 19643175

Article Published Date : Oct 29, 2009

Study Type : Animal Study

Additional Links

Substances : Orange: Mandarin

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis

[+]

Angelica sinesis inhibits the progress of radiation-induced pulmonary fibrosis. Mar 01, 2007

Click here to read the entire abstract

Pubmed Data : Zhonghua Yu Fang Yi Xue Za Zhi. 2007 Mar;41(2):105-9. PMID: 17605235

Article Published Date : Mar 01, 2007

Study Type : Animal Study

Additional Links

Substances : Angelica

Diseases : Pulmonary Fibrosis, Radiation Induced Illness: Thoracic

[+]

Beta-sitosterol can be used to attenuate pulmonary fibrosis through suppression of EMT by inhibiting the TGF-β1/Snail pathway.Sep 03, 2019

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2019 Sep 4 ;67(35):9789-9795. Epub 2019 Aug 19. PMID: 31373816

Article Published Date : Sep 03, 2019

Study Type : Animal Study

Additional Links

Substances : Beta Sitosterol, Corn Silk

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor

Additional Keywords : Plant Extracts

[+]

Biochanin-A ameliorates pulmonary fibrosis.Jul 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Phytomedicine. 2020 Aug 1 ;78:153298. Epub 2020 Aug 1. PMID: 32781391

Article Published Date : Jul 31, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Biochanin A

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor

[+]

Cigarette smoke exposure combined with lipopolysaccharides induced pulmonary fibrosis in mice.Jul 31, 2019

Click here to read the entire abstract

Pubmed Data : Respir Physiol Neurobiol. 2019 Aug ;266:9-17. Epub 2019 Apr 22. PMID: 31022471

Article Published Date : Jul 31, 2019

Study Type : Animal Study

Additional Links

Diseases : Lipopolysaccharide-Induced Toxicity, Pulmonary Fibrosis

Problem Substances : Electronic Cigarettes

[+]

Cordyceps alleviates bleomycin-induced alveolitis and fibrosis. Dec 01, 2007

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2007 Dec;32(24):2623-7. PMID: 18338602

Article Published Date : Dec 01, 2007

Study Type : Animal Study

Additional Links

Substances : Cordyceps sinensis

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis

[+]

Curcumin (from Turmeric) reduces oxidative injury associated with idiopathic pulmonary fibrosis.Apr 01, 2006

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2006 Apr;31(8):669-72. PMID: 16830828

Article Published Date : Apr 01, 2006

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Pulmonary Fibrosis

[+]

Curcumin can alleviate alveolitis and pulmonary fibrosis induced by bleomycin in rats.Mar 01, 2007

Click here to read the entire abstract

Pubmed Data : Zhonghua Jie He He Hu Xi Za Zhi. 2007 Mar;30(3):197-201. PMID: 17572999

Article Published Date : Mar 01, 2007

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Alveolitis: Fibrosing, Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis

[+]

Curcumin can induce apoptosis of pulmonary fibroblasts in rats with bleomycin-induced pulmonary fibrosis.Jan 01, 2009

Click here to read the entire abstract

Pubmed Data : Zhonghua Jie He He Hu Xi Za Zhi. 2009 Jan;32(1):37-41. PMID: 19484960

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Apoptotic

[+]

Curcumin has a similar effect to hydrocortisone in preventing bleomycin-induced pulmonary fibrosis. Jun 13, 2007

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2007 Jun 13;112(2):292-9. Epub 2007 Mar 13. PMID: 17434272

Article Published Date : Jun 13, 2007

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis

Additional Keywords : Superiority of Natural Substances versus Drugs

[+]

Curcumin inhibits bleomycin-induced pulmonary fibrosis in rats.Sep 01, 2000

Click here to read the entire abstract

Pubmed Data : Br J Pharmacol. 2000 Sep;131(2):169-72. PMID: 10991907

Article Published Date : Sep 01, 2000

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis

Pharmacological Actions : Anti-Bacterial Agents

[+]

Curcumin inhibits fibrosis-related effects in IPF fibroblasts and in mice following bleomycin-induced lung injury.Jan 08, 2010

Click here to read the entire abstract

Pubmed Data : Am J Physiol Lung Cell Mol Physiol. 2010 Jan 8. Epub 2010 Jan 8. PMID: 20061443

Article Published Date : Jan 08, 2010

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis

Pharmacological Actions : Transforming growth factor beta (TGF-β) inhibitor

Additional Keywords : Drug Side Effect Attenuation

[+]

Curcumin is more effective than prednisone at suppressing bleomycin-induced pulmonary fibrosis in rats. May 01, 2008

Click here to read the entire abstract

Pubmed Data : Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2008 May;26(5):257-61. PMID: 18727865

Article Published Date : May 01, 2008

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis

Pharmacological Actions : Transforming growth factor beta (TGF-β) inhibitor

Additional Keywords : Superiority of Natural Substances versus Drugs

[+]

Curcumin may play its therapetuic role by leveling down the content of extracellular matrix in rats with pulmonary fibrosis induced by bleomycin.Apr 01, 2006

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2006 Apr;31(7):570-3. PMID: 16780161

Article Published Date : Apr 01, 2006

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis

[+]

Curcumin protects against amiodarone-induced pulmonary fibrosis in rats.Aug 01, 2003

Click here to read the entire abstract

Pubmed Data : Br J Pharmacol. 2003 Aug;139(7):1342-50. PMID: 12890714

Article Published Date : Aug 01, 2003

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Curcumin protects against bleomycin-induced damages in pulmonary functions in ratsJun 01, 2008

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2008 Jun;33(12):1434-8. PMID: 18837350

Article Published Date : Jun 01, 2008

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis

[+]

Curcumin was beneficial in acute lung injury and lung fibrosis.Aug 22, 2019

Click here to read the entire abstract

Pubmed Data : Endocr Metab Immune Disord Drug Targets. 2019 Aug 23. Epub 2019 Aug 23. PMID: 31441735

Article Published Date : Aug 22, 2019

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Lung Injury: Acute, Pulmonary Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic

[+]

Diallyl sulfide reduced the bleomycin-induced activation of inducible nitric oxide synthase (iNOS) and nuclear factor kappa-B (NF-kappaB) and decreased the augmented levels of the early inflammatory cytokines, tumour necrosis factor-alpha (TNF-alpha) and Jun 06, 2008

Click here to read the entire abstract

Pubmed Data : Life Sci. 2008 Jun 6;82(23-24):1142-53. Epub 2008 Apr 4. PMID: 18462759

Article Published Date : Jun 06, 2008

Study Type : Animal Study

Additional Links

Substances : Garlic

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice.May 01, 2010

Click here to read the entire abstract

Pubmed Data : Radiat Res. 2010 May;173(5):590-601. PMID: 20426658

Article Published Date : May 01, 2010

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Lung Cancer, Pulmonary Fibrosis, Radiation Induced Illness

Pharmacological Actions : Antioxidants, Radioprotective

[+]

Dietary fish oil and fish and borage oil suppress intrapulmonary inflammation and attenuate pulmonary neutrophil accumulation in endotoxic rats.Jul 01, 1997

Click here to read the entire abstract

Pubmed Data : Crit Care Med. 1997 Jul;25(7):1198-206. PMID: 9233748

Article Published Date : Jul 01, 1997

Study Type : Animal Study

Additional Links

Substances : Borage Oil, EPA (Eicosapentaenoic Acid), Fish Oil

Diseases : Endotoxemia, Pulmonary Fibrosis

[+]

Effect of baicalin on expression of fibrogenic factors TGF-β1, mmp2 and timp2 in tissue of mice with pulmonary fibrosis.Nov 30, 2020

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2020 Dec ;45(23):5738-5744. PMID: 33496114

Article Published Date : Nov 30, 2020

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic

[+]

EGCG exhibits anti-fibrotic effects in a rat model of pulmonary fibrosis. Jul 15, 2009

Click here to read the entire abstract

Pubmed Data : Chem Biol Interact. 2009 Jul 15;180(2):271-80. Epub 2009 Mar 20. PMID: 19497426

Article Published Date : Jul 15, 2009

Study Type : Animal Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis

[+]

Exploring the mechanism whereby sinensetin delays the progression of pulmonary fibrosis.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2021 ;12:693061. Epub 2021 Jun 18. PMID: 34220517

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation

[+]

Ferulic acid combined with astragaloside IV reduced the degree of pulmonary fibrosis.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:8845798. Epub 2021 Mar 2. PMID: 33763150

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Astragaloside, Ferulic acid

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic

Additional Keywords : Natural Substance Synergy

[+]

Fish oil protects against inflammation and fibrosis in the lung and liver. Jun 14, 2002

Click here to read the entire abstract

Pubmed Data : Toxicology. 2002 Jun 14;175(1-3):1-13. PMID: 12049831

Article Published Date : Jun 14, 2002

Study Type : Animal Study

Additional Links

Substances : Fish Oil

Diseases : Liver Fibrosis, Pulmonary Fibrosis

[+]

Galangin ameliorated pulmonary fibrosis in vivo and in vitro by regulating epithelial-mesenchymal transition.Sep 30, 2020

Click here to read the entire abstract

Pubmed Data : Bioorg Med Chem. 2020 Oct 1 ;28(19):115663. Epub 2020 Jul 28. PMID: 32912432

Article Published Date : Sep 30, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Flavonoids

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic

[+]

Ginkgo biloba has a positive effect on pulmonary interstitial fibrosis in ratsJun 01, 2000

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000 Jun;20(6):441-3. PMID: 11789230

Article Published Date : Jun 01, 2000

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis

Pharmacological Actions : NF-kappaB Inhibitor, Transforming growth factor beta (TGF-β) inhibitor

[+]

Grape seed extract attenuates silica-induced pulmonary fibrosis in rats. Aug 01, 2009

Click here to read the entire abstract

Pubmed Data : Reproduction. 2009 Aug;138(2):279-87. Epub 2009 Jun 3. PMID: 18547852

Article Published Date : Aug 01, 2009

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Pulmonary Fibrosis

[+]

Gymnadenia conopsea can ameliorate the silica-induced pulmonary fibrosis by increasing the activities of antioxidase and alleviating the damage of lipid peroxidation to the lungs.Jan 01, 2007

Click here to read the entire abstract

Pubmed Data : Zhong Xi Yi Jie He Xue Bao. 2007 Jan;5(1):50-5. PMID: 17214936

Article Published Date : Jan 01, 2007

Study Type : Animal Study

Additional Links

Substances : Gymnadenia conopsea

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Antioxidants

Additional Keywords : Plant Extracts

[+]

Honokiol ameliorates pulmonary fibrosis.Feb 03, 2020

Click here to read the entire abstract

Pubmed Data : Toxicol Appl Pharmacol. 2020 Feb 4:114913. Epub 2020 Feb 4. PMID: 32032644

Article Published Date : Feb 03, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Honokiol

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation

[+]

Hu Zhang (Polygonum cuspidatum), a rich source of resveratrol, inhibits the expression of inflammation in lung fibroblasts and reduces alveolitis and pulmonary fibrosis. Jun 01, 2009

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2009 Jun;34(12):1574-7. PMID: 19777850

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Hu Zhang (Polygonum cuspidatum), Resveratrol

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis

Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor

[+]

Hyperforin, a compound found within St. John's wort, has powerful anti-inflammatory therapeutic potential in reducing lung fibrosis. May 01, 2007

Click here to read the entire abstract

Pubmed Data : J Pharmacol Exp Ther. 2007 May;321(2):492-500. Epub 2007 Feb 8. PMID: 17289834

Article Published Date : May 01, 2007

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Cystic Fibrosis, Pulmonary Fibrosis

Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor

[+]

Kaempferol inhibits the progression of silica-induced pulmonary fibrosis.Sep 26, 2019

Click here to read the entire abstract

Pubmed Data : DNA Cell Biol. 2019 Sep 27. Epub 2019 Sep 27. PMID: 31560574

Article Published Date : Sep 26, 2019

Study Type : Animal Study

Additional Links

Substances : Kaempferol

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic

[+]

L-carnitine and ginkgo biloba extract exhibits a protective agent in an animal model of bleomycin-induced lung fibrosis Jun 01, 2002

Click here to read the entire abstract

Pubmed Data : Pharmacol Res. 2002 Jun;45(6):461-7. PMID: 12162946

Article Published Date : Jun 01, 2002

Study Type : Animal Study

Additional Links

Substances : Carnitine, Ginkgo biloba

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis

Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

Lecithinized superoxide dismutase has protective activity against bleomycin-induced pulmonary fibrosis. Dec 24, 2009

Click here to read the entire abstract

Pubmed Data : Am J Physiol Lung Cell Mol Physiol. 2009 Dec 24. Epub 2009 Dec 24. PMID: 20034962

Article Published Date : Dec 24, 2009

Study Type : Animal Study

Additional Links

Substances : Lecithin, Superoxide dismutase

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis

Additional Keywords : Drug Side Effect Attenuation

[+]

Low molecular weight fucoidan attenuating pulmonary fibrosis.Nov 30, 2021

Click here to read the entire abstract

Pubmed Data : Carbohydr Polym. 2021 Dec 1 ;273:118567. Epub 2021 Aug 19. PMID: 34560978

Article Published Date : Nov 30, 2021

Study Type : Animal Study

Additional Links

Substances : Fucoidan

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic, Interleukin-6 Downregulation, Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Low-level laser therapy attenuates lung inflammation and airway remodeling in a murine model of idiopathic pulmonary fibrosis.Dec 31, 2019

Click here to read the entire abstract

Pubmed Data : J Photochem Photobiol B. 2020 Jan ;203:111731. Epub 2019 Dec 4. PMID: 31935633

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Diseases : Lung Inflammation, Pulmonary Fibrosis

Therapeutic Actions : Laser Treatment: Low-Level

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents

[+]

N-Acetylcysteine decreases lung inflammation and fibrosis by modulating ROS and Nrf2 in mice model exposed to particulate matter.Jun 02, 2022

Click here to read the entire abstract

Pubmed Data : Immunopharmacol Immunotoxicol. 2022 Jun 3:1-8. Epub 2022 Jun 3. PMID: 35657279

Article Published Date : Jun 02, 2022

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Air Pollution Linked Toxicity, Asthma, Lung Inflammation, Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Nrf2 activation

[+]

N-acetylcysteine therapeutically protects against pulmonary fibrosis in a mouse model of silicosis.Jul 30, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biosci Rep. 2019 Jul 31 ;39(7). Epub 2019 Jul 18. PMID: 31273057

Article Published Date : Jul 30, 2019

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Pulmonary Fibrosis, Silicosis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Naringenin significantly reduces lung metastases in mice with pulmonary fibrosis and increases their survival by improving immune function. Apr 01, 2009

Click here to read the entire abstract

Pubmed Data : Cancer Res. 2009 Apr 1;69(7):3205-12. Epub 2009 Mar 24. PMID: 19318568

Article Published Date : Apr 01, 2009

Study Type : Animal Study

Additional Links

Substances : Naringenin

Diseases : Lung Cancer, Pulmonary Fibrosis

[+]

Niacin could effectively attenuate the over expression of nitric oxide synthase in the rat lung induced by silica particles. May 01, 2004

Click here to read the entire abstract

Pubmed Data : Zhonghua Yu Fang Yi Xue Za Zhi. 2004 May;38(3):186-9. PMID: 15182488

Article Published Date : May 01, 2004

Study Type : Animal Study

Additional Links

Substances : Niacin

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Nitric Oxide Inhibitor

[+]

Panax notoginside compares favorably with methylprednisolone in a rat model of pulmonary fibrosisSep 01, 2002

Click here to read the entire abstract

Pubmed Data : Zhonghua Jie He He Hu Xi Za Zhi. 2002 Sep;25(9):520-3. PMID: 12423557

Article Published Date : Sep 01, 2002

Study Type : Animal Study

Additional Links

Substances : Panax Notoginseng

Diseases : Pulmonary Fibrosis

Additional Keywords : Natural Substances Versus Drugs

[+]

Paraquat induces pulmonary fibrosis through Wnt/β-catenin signaling pathway and myofibroblast differentiation.Oct 14, 2020

Click here to read the entire abstract

Pubmed Data : Toxicol Lett. 2020 Oct 15 ;333:170-183. Epub 2020 Aug 11. PMID: 32795487

Article Published Date : Oct 14, 2020

Study Type : Animal Study

Additional Links

Diseases : Herbicide Toxicity, Pulmonary Fibrosis

Problem Substances : Paraquat

[+]

Perchlorate can induce pulmonary fibrosis in the rabbit lung.Oct 12, 2010

Click here to read the entire abstract

Pubmed Data : Toxicol Ind Health. 2010 Oct 12. Epub 2010 Oct 12. PMID: 20937628

Article Published Date : Oct 12, 2010

Study Type : Animal Study

Additional Links

Diseases : Pulmonary Fibrosis

Problem Substances : Perchlorate

Adverse Pharmacological Actions : Inflammatory

[+]

Pterostilbene prevents LPS-induced early pulmonary fibrosis by suppressing oxidative stress, inflammation and apoptosis in vivo.May 06, 2020

Click here to read the entire abstract

Pubmed Data : Food Funct. 2020 May 7. Epub 2020 May 7. PMID: 32377661

Article Published Date : May 06, 2020

Study Type : Animal Study

Additional Links

Substances : Pterostilbene

Diseases : Lipopolysaccharide-Induced Toxicity, Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

[+]

Pycnogenol can be used to treat pulmonary fibrosis as it hinders fibrosis progression.Oct 11, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Respir Physiol Neurobiol. 2021 Oct 12 ;296:103802. Epub 2021 Oct 12. PMID: 34653662

Article Published Date : Oct 11, 2021

Study Type : Animal Study

Additional Links

Substances : Pycnogenol (Pine Bark)

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents

[+]

Resveratrol alleviates chemotherapy-induced (bleomycin) lung injury in rats. Jan 01, 2007

Click here to read the entire abstract

Pubmed Data : : Pulm Pharmacol Ther. 2007;20(6):642-9. Epub 2006 Sep 3. PMID: 17035056

Article Published Date : Jan 01, 2007

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Chemotherapy-Induced Toxicity, Chemotherapy-Induced Toxicity: Adriamycin, Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis

Additional Keywords : Drug-Plant-Vitamin Synergies

[+]

Role of the Hippo signaling pathway in safflower yellow pigment treatment of paraquat-induced pulmonary fibrosis.Aug 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Int Med Res. 2020 Sep ;48(9):300060520905425. PMID: 32940100

Article Published Date : Aug 31, 2020

Study Type : Animal Study

Additional Links

Substances : Safflower

Diseases : Paraquat Toxicity, Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic

Problem Substances : Paraquat

[+]

Taurine can effectively attenuate type I and III collagen expression in the rat lung induced by silica particles. Sep 01, 2006

Click here to read the entire abstract

Pubmed Data : Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 Sep;24(9):544-6. PMID: 17034730

Article Published Date : Sep 01, 2006

Study Type : Animal Study

Additional Links

Substances : Taurine

Diseases : Pulmonary Fibrosis

[+]

The Chinese medicine DSQRL is superior to prednisone in treating experimental pulmonary fibrosis. Mar 05, 2008

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2008 Mar 5;116(2):318-24. Epub 2007 Dec 4. PMID: 18191351

Article Published Date : Mar 05, 2008

Study Type : Animal Study

Additional Links

Substances : Chinese Herbal Formula: Decoction for Strengthening Qi and Replenishing Lung (DSQRL)

Diseases : Pulmonary Fibrosis

Additional Keywords : Superiority of Natural Substances versus Drugs

[+]

The inhibitory effect of icariin nanoparticles on angiogenesis in pulmonary fibrosis.Dec 31, 2020

Click here to read the entire abstract

Pubmed Data : J Nanosci Nanotechnol. 2021 11 1 ;21(11):5429-5435. PMID: 33980352

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Icariin

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Fibrotic

[+]

These findings confirmed the anti-inflammatory effects of resveratrol and quercetin in BLM-induced lung damage.Aug 31, 2015

Click here to read the entire abstract

Pubmed Data : Br J Nutr. 2015 Sep ;114(6):853-865. PMID: 26334388

Article Published Date : Aug 31, 2015

Study Type : Animal Study

Additional Links

Substances : Mangiferin, Quercetin, Resveratrol

Diseases : Pulmonary Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors

[+]

These results showed engeletin remedies pulmonary fibrogenesis.Nov 30, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharm Biol. 2020 Dec ;58(1):1105-1114. PMID: 33181025

Article Published Date : Nov 30, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Flavonoids

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic

[+]

This study demonstrates the anti-fibrotic effect of tannic acid in vitro and in vivo.Jul 28, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Respir Res. 2019 Jul 29 ;20(1):168. Epub 2019 Jul 29. PMID: 31358001

Article Published Date : Jul 28, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Tannic Acid

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic

[+]

Thymoquinone has the preventive and therapeutic potentials for the treatment of lung fibrosis.Jun 17, 2016

Click here to read the entire abstract

Pubmed Data : Environ Toxicol Pharmacol. 2016 Jun 18 ;45:340-345. Epub 2016 Jun 18. PMID: 27375216

Article Published Date : Jun 17, 2016

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Antioxidants

Additional Keywords : Gene Expression Regulation

Problem Substances : Pesticides

[+]

Treatment with taurine can effectively attenuate the pathological expression of TNF-alpha protein of lung in rats induced by silica.May 01, 2007

Click here to read the entire abstract

Pubmed Data : Wei Sheng Yan Jiu. 2007 May;36(3):364-6. PMID: 17712964

Article Published Date : May 01, 2007

Study Type : Animal Study

Additional Links

Substances : Taurine

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Vitamin D prevents experimental lung fibrosis and predicts survival in patients with idiopathic pulmonary fibrosis.Dec 31, 2018

Click here to read the entire abstract

Pubmed Data : Pulm Pharmacol Ther. 2019 04 ;55:17-24. Epub 2019 Jan 16. PMID: 30659895

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Vitamin D

Diseases : Pulmonary Fibrosis, Vitamin D Deficiency

Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator

[+]

Vtamin E is superior to pentoxifylline in protecting against radiation-induced pulmonary fibrosis in rats. May 01, 2007

Click here to read the entire abstract

Pubmed Data : Clin Oncol (R Coll Radiol). 2007 May;19(4):260-4. Epub 2007 Jan 12. PMID: 17433970

Article Published Date : May 01, 2007

Study Type : Animal Study

Additional Links

Substances : Vitamin E

Diseases : Pulmonary Fibrosis, Radiation Induced Illness: Thoracic

Additional Keywords : Superiority of Natural Substances versus Drugs

[+]

The herbicide paraquat-induced molecular mechanisms in the development of acute lung injury and lung fibrosis.Dec 31, 2020

Click here to read the entire abstract

Pubmed Data : Crit Rev Toxicol. 2021 Jan ;51(1):36-64. Epub 2021 Feb 2. PMID: 33528289

Article Published Date : Dec 31, 2020

Study Type : Review

Additional Links

Diseases : Herbicide Toxicity, Lung Injury: Acute, Pulmonary Fibrosis

[+]

A fundamental treatment goal of pulmonary fibrosis is alhpa(v)beta6-mediated Transforming growth factor (TGF)-beta suppression. Jan 01, 2008

Click here to read the entire abstract

Pubmed Data : Am J Respir Crit Care Med. 2008 Jan 1;177(1):56-65. Epub 2007 Oct 4. PMID: 17916809

Article Published Date : Jan 01, 2008

Study Type : Commentary

Additional Links

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Transforming growth factor beta (TGF-β) inhibitor

[+]

A review of carnosine and lung disease.Jul 11, 2019

Click here to read the entire abstract

Pubmed Data : Curr Med Chem. 2019 Jul 12. Epub 2019 Jul 12. PMID: 31309876

Article Published Date : Jul 11, 2019

Study Type : Review

Additional Links

Diseases : Lipopolysaccharide-Induced Toxicity, Lung Diseases, Oxidative Stress, Pulmonary Fibrosis

Pharmacological Actions : Antioxidants

[+]

An in silico study on pulmonary fibrosis inhibitors from Tinospora cordifolia and Curcuma longa targeting TGF-β RI.Jan 23, 2022

Click here to read the entire abstract

Pubmed Data : J Biomol Struct Dyn. 2022 Jan 24:1-17. Epub 2022 Jan 24. PMID: 35068362

Article Published Date : Jan 23, 2022

Study Type : In Vitro Study

Additional Links

Substances : Guduchi , Turmeric

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic

[+]

Arctigenin suppressed epithelial-mesenchymal transition through Wnt3a/β-catenin pathway in PQ-Induced pulmonary fibrosis Dec 31, 2019

Click here to read the entire abstract

Pubmed Data : Front Pharmacol. 2020 ;11:584098. Epub 2020 Dec 16. PMID: 33390951

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Arctigenin

Diseases : Pesticide Toxicity , Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic

Problem Substances : Paraquat

[+]

Artesunate restraining MAPK passage by smad7 to resist pulmonary fibrosis.Dec 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Eur Rev Med Pharmacol Sci. 2014 ;18(21):3199-204. PMID: 25487928

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Artesunate

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic

[+]

Astaxanthin attenuates pulmonary fibrosis through lncITPF and mitochondria‐mediated signal pathways.Aug 18, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Cell Mol Med. 2020 Aug 19. Epub 2020 Aug 19. PMID: 32813323

Article Published Date : Aug 18, 2020

Study Type : In Vitro Study

Additional Links

Substances : Astaxanthin

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic

[+]

Astragaloside IV alleviates silica‑induced pulmonary fibrosis.Feb 28, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Med. 2021 Mar ;47(3). Epub 2021 Jan 15. PMID: 33448318

Article Published Date : Feb 28, 2021

Study Type : In Vitro Study

Additional Links

Substances : Astragaloside

Diseases : Pulmonary Fibrosis, Silicosis

Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor

[+]

Astragaloside IV attenuates TGF-β-mediated epithelial-mesenchymal transition of pulmonary fibrosis.Feb 24, 2021

Click here to read the entire abstract

Pubmed Data : Pharmazie. 2021 Feb 25 ;76(2):97-102. PMID: 33714286

Article Published Date : Feb 24, 2021

Study Type : In Vitro Study

Additional Links

Substances : Astragaloside

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents

[+]

Blueberry juice attenuates pulmonary fibrosis via blocking the TGF-β1/Smad signaling pathway.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2022 ;13:825915. Epub 2022 Mar 28. PMID: 35418869

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Blueberry

Diseases : Pulmonary Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Transforming growth factor beta (TGF-β) inhibitor

[+]

Combination therapy of tanshinone IIA and puerarin for pulmonary fibrosis.Aug 23, 2021

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2021 Aug 24. Epub 2021 Aug 24. PMID: 34427348

Article Published Date : Aug 23, 2021

Study Type : In Vitro Study

Additional Links

Substances : Puerarin, Tanshinone IIA

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation

[+]

Curcumin not only could inhibit TGF-β2 induced proliferation of lung fibroblasts, but also could inhibit the synthesis of collagens.Sep 30, 2015

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2015 Oct ;35(10):1249-54. PMID: 26677679

Article Published Date : Sep 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Pulmonary Fibrosis

[+]

Efficacy and safety of N-acetylcysteine therapy for idiopathic pulmonary fibrosis.Jun 30, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Ther Med. 2019 Jul ;18(1):802-816. Epub 2019 May 15. PMID: 31258714

Article Published Date : Jun 30, 2019

Study Type : Review

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic

[+]

EGCG inhibits neutrophil-associated damage in a pulmonary inflammation model, significantly reducing fibrosis. Apr 15, 2003

Click here to read the entire abstract

Pubmed Data : J Immunol. 2003 Apr 15;170(8):4335-41. PMID: 12682270

Article Published Date : Apr 15, 2003

Study Type : Review

Additional Links

Substances : Catechin , EGCG (Epigallocatechin gallate), Green Tea

Diseases : Inflammation, Pulmonary Fibrosis

Pharmacological Actions : Anti-Angiogenic, Anti-Inflammatory Agents

Additional Keywords : Plant Extracts

[+]

Ginsenoside Rg3 inhibits pulmonary fibrosis by preventing HIF-1α nuclear localisation.Feb 26, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Pulm Med. 2021 Feb 27 ;21(1):70. Epub 2021 Feb 27. PMID: 33639908

Article Published Date : Feb 26, 2021

Study Type : In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic, Hypoxia-inducible factor-1 (HIF-1) inhibitor

[+]

Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases.Jan 19, 2020

Click here to read the entire abstract

Pubmed Data : Chem Biol Interact. 2020 Jan 20 ;317:108947. Epub 2020 Jan 20. PMID: 31968208

Article Published Date : Jan 19, 2020

Study Type : Review

Additional Links

Substances : Berberine

Diseases : Asthma, Chronic Obstructive Pulmonary Disease, Inflammation, Lung Cancer, Pulmonary Fibrosis

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Ligustrazine, an alkaloid found within Ligusticum, and Red Sage (saliva m.) are more effective than hydrocortisone in reducing collagengene expression in rat pulmonary fibrosis. Jan 01, 1999

Click here to read the entire abstract

Pubmed Data : Zhonghua Jie He He Hu Xi Za Zhi. 1999 Jan;22(1):43-5. PMID: 11812356

Article Published Date : Jan 01, 1999

Study Type : In Vitro Study

Additional Links

Substances : Ligusticum wallichii , Red Sage

Diseases : Pulmonary Fibrosis

Additional Keywords : Superiority of Natural Substances versus Drugs

[+]

Nimbolide as a potent anti-fibrotic agent.Sep 30, 2019

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2019 Oct ;75:105755. Epub 2019 Aug 1. PMID: 31377591

Article Published Date : Sep 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Neem

Diseases : Pulmonary Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents

[+]

Polystyrene nanoplastics induce EMT in A549 cells through multiple mechanisms.Jan 14, 2022

Click here to read the entire abstract

Pubmed Data : J Hazard Mater. 2022 05 15 ;430:128485. Epub 2022 Feb 15. PMID: 35739668

Article Published Date : Jan 14, 2022

Study Type : In Vitro Study

Additional Links

Diseases : Air Pollution Linked Toxicity, Pulmonary Fibrosis

Additional Keywords : Microplastic

Problem Substances : Polystyrene nanoparticles

[+]

Progress in the study of pulmonary fibrosis signaling pathways caused by paraquat poisoning.Feb 28, 2021

Click here to read the entire abstract

Pubmed Data : Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2021 Mar ;33(3):377-380. PMID: 33834986

Article Published Date : Feb 28, 2021

Study Type : Review

Additional Links

Diseases : Herbicide Toxicity, Pulmonary Fibrosis

Problem Substances : Paraquat

[+]

Pterostilbene alleviates pulmonary fibrosis by regulating ASIC2.Jul 27, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Chin Med. 2021 Jul 28 ;16(1):66. Epub 2021 Jul 28. PMID: 34321072

Article Published Date : Jul 27, 2021

Study Type : In Vitro Study

Additional Links

Substances : Pterostilbene

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic

[+]

Puerarin regulated the proliferation and apoptosis of pulmonary fibrosis cells.Aug 30, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Med Sci Monit. 2019 Aug 31 ;25:6523-6531. Epub 2019 Aug 31. PMID: 31471534

Article Published Date : Aug 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Puerarin

Diseases : Acute Respiratory Distress Syndrome, Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic, Interleukin-2 Downregulation, Interleukin-4 downregulation, Transforming growth factor beta (TGF-β) inhibitor

[+]

Resveratrol may have therapeutic value in pulmonary fibrosis. Jan 26, 2011

Click here to read the entire abstract

Pubmed Data : Exp Lung Res. 2011 Jan 26. Epub 2011 Jan 26. PMID: 21269063

Article Published Date : Jan 26, 2011

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Transforming growth factor beta (TGF-β) inhibitor

[+]

Review: Molecular basis of lung tissue regeneration.Apr 01, 2011

Click here to read the entire abstract

Pubmed Data : Gen Thorac Cardiovasc Surg. 2011 Apr;59(4):231-44. Epub 2011 Apr 12. PMID: 21484549

Article Published Date : Apr 01, 2011

Study Type : Review

Additional Links

Diseases : Pulmonary Fibrosis

[+]

Saikosaponin D plays an important role in anti-pulmonary fibrosis by regulating TGF-β1/Smads signalling pathway.Feb 28, 2019

Click here to read the entire abstract

Pubmed Data : Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2019 Mar ;35(3):256-261. PMID: 31030720

Article Published Date : Feb 28, 2019

Study Type : In Vitro Study

Additional Links

Substances : Saikosaponin

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic

Additional Keywords : Dose Response

[+]

Salvianolic acid B and sodium tanshinone II A sulfonate prevent pulmonary fibrosis through anti-inflammatory and anti-fibrotic process.Jul 05, 2020

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2020 Jul 6 ;883:173352. Epub 2020 Jul 6. PMID: 32645333

Article Published Date : Jul 05, 2020

Study Type : In Vitro Study

Additional Links

Substances : Salvia miltiorrhiza, Tanshinone IIA

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents

[+]

Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis.Dec 31, 2017

Click here to read the entire abstract

Pubmed Data : Biochem Biophys Res Commun. 2018 01 1 ;495(1):325-331. Epub 2017 Nov 4. PMID: 29108993

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Red Sage

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Antioxidants, Nrf2 activation

[+]

Tanshinone IIA attenuates silica-induced pulmonary fibrosis.Feb 29, 2020

Click here to read the entire abstract

Pubmed Data : Chem Biol Interact. 2020 Mar 1 ;319:109024. Epub 2020 Feb 22. PMID: 32097614

Article Published Date : Feb 29, 2020

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Nrf2 activation, Transforming growth factor beta (TGF-β) inhibitor

[+]

The ameliorative effects of arctiin and arctigenin on the oxidative injury of lung induced by silica.Dec 31, 2020

Click here to read the entire abstract

Pubmed Data : Oxid Med Cell Longev. 2021 ;2021:5598980. Epub 2021 Jul 17. PMID: 34336106

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Arctigenin

Diseases : Lung Injury: Acute, Oxidative Stress, Pulmonary Fibrosis, Silicosis

Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor

[+]

The effect of Ocimum basilicum L. and its main ingredients on respiratory disorders.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2021 ;12:805391. Epub 2022 Jan 3. PMID: 35046828

Article Published Date : Dec 31, 2020

Study Type : Review

Additional Links

Substances : Basil

Diseases : Asthma, Bronchitis, Chronic Obstructive Pulmonary Disease, Lung Cancer, Pulmonary Fibrosis, Respiratory Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Immunomodulatory

[+]

The present study is the first to demonstrate that melatonin can protect human alveolar epithelial cells against oxidative stress.Nov 30, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2020 Dec ;132:110827. Epub 2020 Oct 13. PMID: 33065391

Article Published Date : Nov 30, 2020

Study Type : In Vitro Study

Additional Links

Substances : Melatonin

Diseases : Lipopolysaccharide-Induced Toxicity, Pulmonary Fibrosis

Pharmacological Actions : Antioxidants, Nrf2 activation

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Breathing exercises complements exercise training towards improved dyspnea and health-related quality of life in patients with Idiopathic pulmonary fibrosis.Feb 29, 2020

Adding inspiratory muscle training increases effectiveness of pulmonary rehabilitation in idiopathic pulmonary fibrosis patients.Jan 01, 2008

Dietary fat and meat intake are correlated with increased risk for idiopathic pulmonary fibrosis. Mar 01, 2006

Ginkgo is effective in treating pulmonary interstitial fibrosis.Mar 01, 2005

Moxibustion can significantly suppress the expression of TGF-beta1mRNA in the pulmonary tissue in the rat of bleomycin-induced pulmonary fibrosis.Nov 01, 2005

NAC could ameliorate COPD-induced pulmonary fibrosis by promoting immune response.Jan 02, 2021

Oral sulforaphane safely and effectively induces mucosal Phase II enzyme expression in the upper airway of human subjects. Mar 01, 2009

Pycnogenol®-Centellicum® supplementation improves lung fibrosis and Post-Covid-19 lung healing.Jun 27, 2021

Soluble fiber and fruit intake may confer protection against the development of idiopathic pulmonary fibrosis (IPF).Nov 01, 2004

A case report of idiopathic pulmonary fibrosis after the H1N1 influenza vaccine.Jan 01, 2010

Low molecular weight fucoidan inhibits pulmonary fibrosis.Dec 31, 2021

6-Gingerol, a functional polyphenol of ginger, reduces pulmonary fibrosis by activating Sirtuin1.Dec 31, 2021

Alpha lipoic acid attenuates bleomycin-induced pulmonary fibrosis in mice. Jun 01, 2007

An extract of Mandarin Orange demonstrates anti-pulmonary fibrosis effects. Oct 29, 2009

Angelica sinesis inhibits the progress of radiation-induced pulmonary fibrosis. Mar 01, 2007

Beta-sitosterol can be used to attenuate pulmonary fibrosis through suppression of EMT by inhibiting the TGF-β1/Snail pathway.Sep 03, 2019

Biochanin-A ameliorates pulmonary fibrosis.Jul 31, 2020

Cigarette smoke exposure combined with lipopolysaccharides induced pulmonary fibrosis in mice.Jul 31, 2019

Cordyceps alleviates bleomycin-induced alveolitis and fibrosis. Dec 01, 2007

Curcumin (from Turmeric) reduces oxidative injury associated with idiopathic pulmonary fibrosis.Apr 01, 2006

Curcumin can alleviate alveolitis and pulmonary fibrosis induced by bleomycin in rats.Mar 01, 2007

Curcumin can induce apoptosis of pulmonary fibroblasts in rats with bleomycin-induced pulmonary fibrosis.Jan 01, 2009

Curcumin has a similar effect to hydrocortisone in preventing bleomycin-induced pulmonary fibrosis. Jun 13, 2007

Curcumin inhibits bleomycin-induced pulmonary fibrosis in rats.Sep 01, 2000

Curcumin inhibits fibrosis-related effects in IPF fibroblasts and in mice following bleomycin-induced lung injury.Jan 08, 2010

Curcumin is more effective than prednisone at suppressing bleomycin-induced pulmonary fibrosis in rats. May 01, 2008

Curcumin may play its therapetuic role by leveling down the content of extracellular matrix in rats with pulmonary fibrosis induced by bleomycin.Apr 01, 2006

Curcumin protects against amiodarone-induced pulmonary fibrosis in rats.Aug 01, 2003

Curcumin protects against bleomycin-induced damages in pulmonary functions in ratsJun 01, 2008

Curcumin was beneficial in acute lung injury and lung fibrosis.Aug 22, 2019

Diallyl sulfide reduced the bleomycin-induced activation of inducible nitric oxide synthase (iNOS) and nuclear factor kappa-B (NF-kappaB) and decreased the augmented levels of the early inflammatory cytokines, tumour necrosis factor-alpha (TNF-alpha) and Jun 06, 2008

Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice.May 01, 2010

Dietary fish oil and fish and borage oil suppress intrapulmonary inflammation and attenuate pulmonary neutrophil accumulation in endotoxic rats.Jul 01, 1997

Effect of baicalin on expression of fibrogenic factors TGF-β1, mmp2 and timp2 in tissue of mice with pulmonary fibrosis.Nov 30, 2020

EGCG exhibits anti-fibrotic effects in a rat model of pulmonary fibrosis. Jul 15, 2009

Exploring the mechanism whereby sinensetin delays the progression of pulmonary fibrosis.Dec 31, 2020

Ferulic acid combined with astragaloside IV reduced the degree of pulmonary fibrosis.Dec 31, 2020

Fish oil protects against inflammation and fibrosis in the lung and liver. Jun 14, 2002

Galangin ameliorated pulmonary fibrosis in vivo and in vitro by regulating epithelial-mesenchymal transition.Sep 30, 2020

Ginkgo biloba has a positive effect on pulmonary interstitial fibrosis in ratsJun 01, 2000

Grape seed extract attenuates silica-induced pulmonary fibrosis in rats. Aug 01, 2009

Gymnadenia conopsea can ameliorate the silica-induced pulmonary fibrosis by increasing the activities of antioxidase and alleviating the damage of lipid peroxidation to the lungs.Jan 01, 2007

Honokiol ameliorates pulmonary fibrosis.Feb 03, 2020

Hu Zhang (Polygonum cuspidatum), a rich source of resveratrol, inhibits the expression of inflammation in lung fibroblasts and reduces alveolitis and pulmonary fibrosis. Jun 01, 2009

Hyperforin, a compound found within St. John's wort, has powerful anti-inflammatory therapeutic potential in reducing lung fibrosis. May 01, 2007

Kaempferol inhibits the progression of silica-induced pulmonary fibrosis.Sep 26, 2019

L-carnitine and ginkgo biloba extract exhibits a protective agent in an animal model of bleomycin-induced lung fibrosis Jun 01, 2002

Lecithinized superoxide dismutase has protective activity against bleomycin-induced pulmonary fibrosis. Dec 24, 2009

Low molecular weight fucoidan attenuating pulmonary fibrosis.Nov 30, 2021

Low-level laser therapy attenuates lung inflammation and airway remodeling in a murine model of idiopathic pulmonary fibrosis.Dec 31, 2019

N-Acetylcysteine decreases lung inflammation and fibrosis by modulating ROS and Nrf2 in mice model exposed to particulate matter.Jun 02, 2022

N-acetylcysteine therapeutically protects against pulmonary fibrosis in a mouse model of silicosis.Jul 30, 2019

Naringenin significantly reduces lung metastases in mice with pulmonary fibrosis and increases their survival by improving immune function. Apr 01, 2009

Niacin could effectively attenuate the over expression of nitric oxide synthase in the rat lung induced by silica particles. May 01, 2004

Panax notoginside compares favorably with methylprednisolone in a rat model of pulmonary fibrosisSep 01, 2002

Paraquat induces pulmonary fibrosis through Wnt/β-catenin signaling pathway and myofibroblast differentiation.Oct 14, 2020

Perchlorate can induce pulmonary fibrosis in the rabbit lung.Oct 12, 2010

Pterostilbene prevents LPS-induced early pulmonary fibrosis by suppressing oxidative stress, inflammation and apoptosis in vivo.May 06, 2020

Pycnogenol can be used to treat pulmonary fibrosis as it hinders fibrosis progression.Oct 11, 2021

Resveratrol alleviates chemotherapy-induced (bleomycin) lung injury in rats. Jan 01, 2007

Role of the Hippo signaling pathway in safflower yellow pigment treatment of paraquat-induced pulmonary fibrosis.Aug 31, 2020

Taurine can effectively attenuate type I and III collagen expression in the rat lung induced by silica particles. Sep 01, 2006

The Chinese medicine DSQRL is superior to prednisone in treating experimental pulmonary fibrosis. Mar 05, 2008

The inhibitory effect of icariin nanoparticles on angiogenesis in pulmonary fibrosis.Dec 31, 2020

These findings confirmed the anti-inflammatory effects of resveratrol and quercetin in BLM-induced lung damage.Aug 31, 2015

These results showed engeletin remedies pulmonary fibrogenesis.Nov 30, 2020

This study demonstrates the anti-fibrotic effect of tannic acid in vitro and in vivo.Jul 28, 2019

Thymoquinone has the preventive and therapeutic potentials for the treatment of lung fibrosis.Jun 17, 2016

Treatment with taurine can effectively attenuate the pathological expression of TNF-alpha protein of lung in rats induced by silica.May 01, 2007

Vitamin D prevents experimental lung fibrosis and predicts survival in patients with idiopathic pulmonary fibrosis.Dec 31, 2018

Vtamin E is superior to pentoxifylline in protecting against radiation-induced pulmonary fibrosis in rats. May 01, 2007

The herbicide paraquat-induced molecular mechanisms in the development of acute lung injury and lung fibrosis.Dec 31, 2020

Pulmonary Fibrosis

View the Evidence:
102 Abstracts with Pulmonary Fibrosis Research