Pulmonary Fibrosis

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35 Substances Researched for Pulmonary Fibrosis
NameACCKFocus
Curcumin1223Locked
Ginkgo biloba314Locked
Fiber110Locked
Fruit: All110Locked
Sulforaphane110Locked
Resveratrol47Locked
Fish Oil24Locked
Taurine24Locked
EGCG (Epigallocatechin gallate)23Locked
Alpha-Lipoic Acid12Locked
Angelica12Locked
Borage Oil12Locked
Carnitine12Locked
Chinese Herbal Formula: Decoction for Strengthening Qi and Replenishing Lung (DSQRL)12Locked
Cordyceps sinensis12Locked
EPA (Eicosapentaenoic Acid)12Locked
Garlic12Locked
Grape Seed Extract12Locked
Gymnadenia conopsea12Locked
Hu Zhang (Polygonum cuspidatum)12Locked
Lecithin12Locked
Mangiferin12Locked
Naringenin 12Locked
Niacin12Locked
Orange: Mandarin12Locked
Panax Notoginseng12Locked
Quercetin12Locked
St. Johns Wort12Locked
Superoxide dismutase12Locked
Thymoquinone12Locked
Vitamin E12Locked
Catechin 11Locked
Green Tea11Locked
Ligusticum wallichii 11Locked
Red Sage11Locked
2 Problem Substances Researched for Pulmonary Fibrosis
NameACCKFocus
Perchlorate12Locked
Pesticides12Locked
4 Therapeutic Actions Researched for Pulmonary Fibrosis
NameACCKFocus
Dietary Modification: Low Fat Diet110Locked
Dietary Modification: Vegetarian110Locked
Exercise: Inspiratory Muscle Training110Locked
Moxibustion110Locked

View the Evidence:
77 Abstracts with Pulmonary Fibrosis Research

[+]

Breathing exercises complements exercise training towards improved dyspnea and health-related quality of life in patients with Idiopathic pulmonary fibrosis.Feb 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Thorac Dis. 2020 Mar ;12(3):1041-1055. PMID: 32274173
Article Published Date : Feb 29, 2020
Study Type : Meta Analysis, Review
Additional Links
Diseases : Pulmonary Fibrosis
Therapeutic Actions : Exercise: Aerobic, Therapeutic Breathing
[+]

Adding inspiratory muscle training increases effectiveness of pulmonary rehabilitation in idiopathic pulmonary fibrosis patients.Jan 01, 2008

Pubmed Data : Pneumonol Alergol Pol. 2008;76(3):131-41. PMID: 18843927
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Diseases : Pulmonary Fibrosis
Therapeutic Actions : Exercise: Inspiratory Muscle Training
[+]

Dietary fat and meat intake are correlated with increased risk for idiopathic pulmonary fibrosis. Mar 01, 2006

Pubmed Data : Int J Tuberc Lung Dis. 2006 Mar;10(3):333-9. PMID: 16562716
Article Published Date : Mar 01, 2006
Study Type : Human Study
Additional Links
Diseases : Pulmonary Fibrosis
Therapeutic Actions : Dietary Modification: Low Fat Diet, Dietary Modification: Vegetarian
[+]

Ginkgo is effective in treating pulmonary interstitial fibrosis.Mar 01, 2005

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005 Mar;25(3):222-4. PMID: 15842142
Article Published Date : Mar 01, 2005
Study Type : Human Study
Additional Links
Substances : Ginkgo biloba
Diseases : Interstitial Lung Diseases, Pulmonary Fibrosis
Pharmacological Actions : Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Natural Substances Versus Drugs
[+]

Moxibustion can significantly suppress the expression of TGF-beta1mRNA in the pulmonary tissue in the rat of bleomycin-induced pulmonary fibrosis.Nov 01, 2005

Pubmed Data : Zhongguo Zhen Jiu. 2005 Nov;25(11):790-2. PMID: 16335208
Article Published Date : Nov 01, 2005
Study Type : Human Study
Additional Links
Diseases : Pulmonary Fibrosis
Therapeutic Actions : Moxibustion
Pharmacological Actions : Transforming growth factor beta (TGF-β) inhibitor
[+]

Oral sulforaphane safely and effectively induces mucosal Phase II enzyme expression in the upper airway of human subjects. Mar 01, 2009

Pubmed Data : Clin Immunol. 2009 Mar;130(3):244-51. Epub 2008 Nov 22. PMID: 19028145
Article Published Date : Mar 01, 2009
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : COPD, Cystic Fibrosis, Glutathione Deficiency , Lung Diseases, Pulmonary Fibrosis, Respiratory Diseases
Pharmacological Actions : Antioxidants, Glutathione Upregulation , Phase II Detoxification Enzyme Inducer
Additional Keywords : Isothiocyanates
[+]

Soluble fiber and fruit intake may confer protection against the development of idiopathic pulmonary fibrosis (IPF).Nov 01, 2004

Pubmed Data : Ann Nutr Metab. 2004 Nov-Dec;48(6):390-7. Epub 2004 Nov 30. PMID: 15583467
Article Published Date : Nov 01, 2004
Study Type : Human Study
Additional Links
Substances : Fiber, Fruit: All
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Antioxidants
Additional Keywords : Risk Reduction
[+]

A case report of idiopathic pulmonary fibrosis after the H1N1 influenza vaccine.Jan 01, 2010

Pubmed Data : Intern Med. 2010 ;49(21):2333-6. Epub 2010 Nov 1. PMID: 21048370
Article Published Date : Jan 01, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Pulmonary Fibrosis
Anti Therapeutic Actions : Vaccination: All, Vaccination: Influenza
[+]

Alpha lipoic acid attenuates bleomycin-induced pulmonary fibrosis in mice. Jun 01, 2007

Pubmed Data : Int J Mol Med. 2007 Jun;19(6):865-73. PMID: 17487418
Article Published Date : Jun 01, 2007
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
[+]

An extract of Mandarin Orange demonstrates anti-pulmonary fibrosis effects. Oct 29, 2009

Pubmed Data : J Ethnopharmacol. 2009 Oct 29;126(1):143-8. Epub 2009 Jul 28. PMID: 19643175
Article Published Date : Oct 29, 2009
Study Type : Animal Study
Additional Links
Substances : Orange: Mandarin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
[+]

Angelica sinesis inhibits the progress of radiation-induced pulmonary fibrosis. Mar 01, 2007

Pubmed Data : Zhonghua Yu Fang Yi Xue Za Zhi. 2007 Mar;41(2):105-9. PMID: 17605235
Article Published Date : Mar 01, 2007
Study Type : Animal Study
Additional Links
Substances : Angelica
Diseases : Pulmonary Fibrosis, Radiation Induced Illness: Thoracic
[+]

Beta-sitosterol can be used to attenuate pulmonary fibrosis through suppression of EMT by inhibiting the TGF-β1/Snail pathway.Sep 03, 2019

Pubmed Data : J Agric Food Chem. 2019 Sep 4 ;67(35):9789-9795. Epub 2019 Aug 19. PMID: 31373816
Article Published Date : Sep 03, 2019
Study Type : Animal Study
Additional Links
Substances : Beta Sitosterol, Corn Silk
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor
Additional Keywords : Plant Extracts
[+]

Biochanin-A ameliorates pulmonary fibrosis.Jul 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Phytomedicine. 2020 Aug 1 ;78:153298. Epub 2020 Aug 1. PMID: 32781391
Article Published Date : Jul 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor
[+]

Cigarette smoke exposure combined with lipopolysaccharides induced pulmonary fibrosis in mice.Jul 31, 2019

Pubmed Data : Respir Physiol Neurobiol. 2019 Aug ;266:9-17. Epub 2019 Apr 22. PMID: 31022471
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Diseases : Lipopolysaccharide-Induced Toxicity, Pulmonary Fibrosis
Problem Substances : Electronic Cigarettes
[+]

Cordyceps alleviates bleomycin-induced alveolitis and fibrosis. Dec 01, 2007

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2007 Dec;32(24):2623-7. PMID: 18338602
Article Published Date : Dec 01, 2007
Study Type : Animal Study
Additional Links
Substances : Cordyceps sinensis
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
[+]

Curcumin (from Turmeric) reduces oxidative injury associated with idiopathic pulmonary fibrosis.Apr 01, 2006

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2006 Apr;31(8):669-72. PMID: 16830828
Article Published Date : Apr 01, 2006
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Pulmonary Fibrosis
[+]

Curcumin can alleviate alveolitis and pulmonary fibrosis induced by bleomycin in rats.Mar 01, 2007

Pubmed Data : Zhonghua Jie He He Hu Xi Za Zhi. 2007 Mar;30(3):197-201. PMID: 17572999
Article Published Date : Mar 01, 2007
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Alveolitis: Fibrosing, Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
[+]

Curcumin can induce apoptosis of pulmonary fibroblasts in rats with bleomycin-induced pulmonary fibrosis.Jan 01, 2009

Pubmed Data : Zhonghua Jie He He Hu Xi Za Zhi. 2009 Jan;32(1):37-41. PMID: 19484960
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Apoptotic
[+]

Curcumin has a similar effect to hydrocortisone in preventing bleomycin-induced pulmonary fibrosis. Jun 13, 2007

Pubmed Data : J Ethnopharmacol. 2007 Jun 13;112(2):292-9. Epub 2007 Mar 13. PMID: 17434272
Article Published Date : Jun 13, 2007
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Curcumin inhibits bleomycin-induced pulmonary fibrosis in rats.Sep 01, 2000

Pubmed Data : Br J Pharmacol. 2000 Sep;131(2):169-72. PMID: 10991907
Article Published Date : Sep 01, 2000
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Pharmacological Actions : Anti-Bacterial Agents
[+]

Curcumin inhibits fibrosis-related effects in IPF fibroblasts and in mice following bleomycin-induced lung injury.Jan 08, 2010

Pubmed Data : Am J Physiol Lung Cell Mol Physiol. 2010 Jan 8. Epub 2010 Jan 8. PMID: 20061443
Article Published Date : Jan 08, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Pharmacological Actions : Transforming growth factor beta (TGF-β) inhibitor
Additional Keywords : Drug Side Effect Attenuation
[+]

Curcumin is more effective than prednisone at suppressing bleomycin-induced pulmonary fibrosis in rats. May 01, 2008

Pubmed Data : Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2008 May;26(5):257-61. PMID: 18727865
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Pharmacological Actions : Transforming growth factor beta (TGF-β) inhibitor
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Curcumin may play its therapetuic role by leveling down the content of extracellular matrix in rats with pulmonary fibrosis induced by bleomycin.Apr 01, 2006

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2006 Apr;31(7):570-3. PMID: 16780161
Article Published Date : Apr 01, 2006
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
[+]

Curcumin protects against amiodarone-induced pulmonary fibrosis in rats.Aug 01, 2003

Pubmed Data : Br J Pharmacol. 2003 Aug;139(7):1342-50. PMID: 12890714
Article Published Date : Aug 01, 2003
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin protects against bleomycin-induced damages in pulmonary functions in ratsJun 01, 2008

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2008 Jun;33(12):1434-8. PMID: 18837350
Article Published Date : Jun 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
[+]

Curcumin was beneficial in acute lung injury and lung fibrosis.Aug 22, 2019

Pubmed Data : Endocr Metab Immune Disord Drug Targets. 2019 Aug 23. Epub 2019 Aug 23. PMID: 31441735
Article Published Date : Aug 22, 2019
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Lung Injury: Acute, Pulmonary Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic
[+]

Diallyl sulfide reduced the bleomycin-induced activation of inducible nitric oxide synthase (iNOS) and nuclear factor kappa-B (NF-kappaB) and decreased the augmented levels of the early inflammatory cytokines, tumour necrosis factor-alpha (TNF-alpha) and Jun 06, 2008

Pubmed Data : Life Sci. 2008 Jun 6;82(23-24):1142-53. Epub 2008 Apr 4. PMID: 18462759
Article Published Date : Jun 06, 2008
Study Type : Animal Study
Additional Links
Substances : Garlic
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice.May 01, 2010

Pubmed Data : Radiat Res. 2010 May;173(5):590-601. PMID: 20426658
Article Published Date : May 01, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Lung Cancer, Pulmonary Fibrosis, Radiation Induced Illness
Pharmacological Actions : Antioxidants, Radioprotective
[+]

Dietary fish oil and fish and borage oil suppress intrapulmonary inflammation and attenuate pulmonary neutrophil accumulation in endotoxic rats.Jul 01, 1997

Pubmed Data : Crit Care Med. 1997 Jul;25(7):1198-206. PMID: 9233748
Article Published Date : Jul 01, 1997
Study Type : Animal Study
Additional Links
Substances : Borage Oil, EPA (Eicosapentaenoic Acid), Fish Oil
Diseases : Endotoxemia, Pulmonary Fibrosis
[+]

EGCG exhibits anti-fibrotic effects in a rat model of pulmonary fibrosis. Jul 15, 2009

Pubmed Data : Chem Biol Interact. 2009 Jul 15;180(2):271-80. Epub 2009 Mar 20. PMID: 19497426
Article Published Date : Jul 15, 2009
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
[+]

Fish oil protects against inflammation and fibrosis in the lung and liver. Jun 14, 2002

Pubmed Data : Toxicology. 2002 Jun 14;175(1-3):1-13. PMID: 12049831
Article Published Date : Jun 14, 2002
Study Type : Animal Study
Additional Links
Substances : Fish Oil
Diseases : Liver Fibrosis, Pulmonary Fibrosis
[+]

Galangin ameliorated pulmonary fibrosis in vivo and in vitro by regulating epithelial-mesenchymal transition.Sep 30, 2020

Pubmed Data : Bioorg Med Chem. 2020 Oct 1 ;28(19):115663. Epub 2020 Jul 28. PMID: 32912432
Article Published Date : Sep 30, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Ginkgo biloba has a positive effect on pulmonary interstitial fibrosis in ratsJun 01, 2000

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000 Jun;20(6):441-3. PMID: 11789230
Article Published Date : Jun 01, 2000
Study Type : Animal Study
Additional Links
Substances : Ginkgo biloba
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Pharmacological Actions : NF-kappaB Inhibitor, Transforming growth factor beta (TGF-β) inhibitor
[+]

Grape seed extract attenuates silica-induced pulmonary fibrosis in rats. Aug 01, 2009

Pubmed Data : Reproduction. 2009 Aug;138(2):279-87. Epub 2009 Jun 3. PMID: 18547852
Article Published Date : Aug 01, 2009
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Pulmonary Fibrosis
[+]

Gymnadenia conopsea can ameliorate the silica-induced pulmonary fibrosis by increasing the activities of antioxidase and alleviating the damage of lipid peroxidation to the lungs.Jan 01, 2007

Pubmed Data : Zhong Xi Yi Jie He Xue Bao. 2007 Jan;5(1):50-5. PMID: 17214936
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Substances : Gymnadenia conopsea
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts
[+]

Honokiol ameliorates pulmonary fibrosis.Feb 03, 2020

Pubmed Data : Toxicol Appl Pharmacol. 2020 Feb 4:114913. Epub 2020 Feb 4. PMID: 32032644
Article Published Date : Feb 03, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Honokiol
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation
[+]

Hu Zhang (Polygonum cuspidatum), a rich source of resveratrol, inhibits the expression of inflammation in lung fibroblasts and reduces alveolitis and pulmonary fibrosis. Jun 01, 2009

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2009 Jun;34(12):1574-7. PMID: 19777850
Article Published Date : Jun 01, 2009
Study Type : Animal Study
Additional Links
Substances : Hu Zhang (Polygonum cuspidatum), Resveratrol
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]

Hyperforin, a compound found within St. John's wort, has powerful anti-inflammatory therapeutic potential in reducing lung fibrosis. May 01, 2007

Pubmed Data : J Pharmacol Exp Ther. 2007 May;321(2):492-500. Epub 2007 Feb 8. PMID: 17289834
Article Published Date : May 01, 2007
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Cystic Fibrosis, Pulmonary Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]

Kaempferol inhibits the progression of silica-induced pulmonary fibrosis.Sep 26, 2019

Pubmed Data : DNA Cell Biol. 2019 Sep 27. Epub 2019 Sep 27. PMID: 31560574
Article Published Date : Sep 26, 2019
Study Type : Animal Study
Additional Links
Substances : Kaempferol
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

L-carnitine and ginkgo biloba extract exhibits a protective agent in an animal model of bleomycin-induced lung fibrosis Jun 01, 2002

Pubmed Data : Pharmacol Res. 2002 Jun;45(6):461-7. PMID: 12162946
Article Published Date : Jun 01, 2002
Study Type : Animal Study
Additional Links
Substances : Carnitine, Ginkgo biloba
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Lecithinized superoxide dismutase has protective activity against bleomycin-induced pulmonary fibrosis. Dec 24, 2009

Pubmed Data : Am J Physiol Lung Cell Mol Physiol. 2009 Dec 24. Epub 2009 Dec 24. PMID: 20034962
Article Published Date : Dec 24, 2009
Study Type : Animal Study
Additional Links
Substances : Lecithin, Superoxide dismutase
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Additional Keywords : Drug Side Effect Attenuation
[+]

Low-level laser therapy attenuates lung inflammation and airway remodeling in a murine model of idiopathic pulmonary fibrosis.Dec 31, 2019

Pubmed Data : J Photochem Photobiol B. 2020 Jan ;203:111731. Epub 2019 Dec 4. PMID: 31935633
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Diseases : Lung Inflammation, Pulmonary Fibrosis
Therapeutic Actions : Laser Treatment: Low-Level
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

N-acetylcysteine therapeutically protects against pulmonary fibrosis in a mouse model of silicosis.Jul 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biosci Rep. 2019 Jul 31 ;39(7). Epub 2019 Jul 18. PMID: 31273057
Article Published Date : Jul 30, 2019
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Pulmonary Fibrosis, Silicosis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Naringenin significantly reduces lung metastases in mice with pulmonary fibrosis and increases their survival by improving immune function. Apr 01, 2009

Pubmed Data : Cancer Res. 2009 Apr 1;69(7):3205-12. Epub 2009 Mar 24. PMID: 19318568
Article Published Date : Apr 01, 2009
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Lung Cancer, Pulmonary Fibrosis
[+]

Niacin could effectively attenuate the over expression of nitric oxide synthase in the rat lung induced by silica particles. May 01, 2004

Pubmed Data : Zhonghua Yu Fang Yi Xue Za Zhi. 2004 May;38(3):186-9. PMID: 15182488
Article Published Date : May 01, 2004
Study Type : Animal Study
Additional Links
Substances : Niacin
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Nitric Oxide Inhibitor
[+]

Panax notoginside compares favorably with methylprednisolone in a rat model of pulmonary fibrosisSep 01, 2002

Pubmed Data : Zhonghua Jie He He Hu Xi Za Zhi. 2002 Sep;25(9):520-3. PMID: 12423557
Article Published Date : Sep 01, 2002
Study Type : Animal Study
Additional Links
Substances : Panax Notoginseng
Diseases : Pulmonary Fibrosis
Additional Keywords : Natural Substances Versus Drugs
[+]

Paraquat induces pulmonary fibrosis through Wnt/β-catenin signaling pathway and myofibroblast differentiation.Oct 14, 2020

Pubmed Data : Toxicol Lett. 2020 Oct 15 ;333:170-183. Epub 2020 Aug 11. PMID: 32795487
Article Published Date : Oct 14, 2020
Study Type : Animal Study
Additional Links
Diseases : Herbicide Toxicity, Pulmonary Fibrosis
Problem Substances : Paraquat
[+]

Perchlorate can induce pulmonary fibrosis in the rabbit lung.Oct 12, 2010

Pubmed Data : Toxicol Ind Health. 2010 Oct 12. Epub 2010 Oct 12. PMID: 20937628
Article Published Date : Oct 12, 2010
Study Type : Animal Study
Additional Links
Diseases : Pulmonary Fibrosis
Problem Substances : Perchlorate
Adverse Pharmacological Actions : Inflammatory
[+]

Pterostilbene prevents LPS-induced early pulmonary fibrosis by suppressing oxidative stress, inflammation and apoptosis in vivo.May 06, 2020

Pubmed Data : Food Funct. 2020 May 7. Epub 2020 May 7. PMID: 32377661
Article Published Date : May 06, 2020
Study Type : Animal Study
Additional Links
Substances : Pterostilbene
Diseases : Lipopolysaccharide-Induced Toxicity, Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Resveratrol alleviates chemotherapy-induced (bleomycin) lung injury in rats. Jan 01, 2007

Pubmed Data : : Pulm Pharmacol Ther. 2007;20(6):642-9. Epub 2006 Sep 3. PMID: 17035056
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Chemotherapy-Induced Toxicity, Chemotherapy-Induced Toxicity: Adriamycin, Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Taurine can effectively attenuate type I and III collagen expression in the rat lung induced by silica particles. Sep 01, 2006

Pubmed Data : Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 Sep;24(9):544-6. PMID: 17034730
Article Published Date : Sep 01, 2006
Study Type : Animal Study
Additional Links
Substances : Taurine
Diseases : Pulmonary Fibrosis
[+]

The Chinese medicine DSQRL is superior to prednisone in treating experimental pulmonary fibrosis. Mar 05, 2008

Pubmed Data : J Ethnopharmacol. 2008 Mar 5;116(2):318-24. Epub 2007 Dec 4. PMID: 18191351
Article Published Date : Mar 05, 2008
Study Type : Animal Study
Additional Links
Substances : Chinese Herbal Formula: Decoction for Strengthening Qi and Replenishing Lung (DSQRL)
Diseases : Pulmonary Fibrosis
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

These findings confirmed the anti-inflammatory effects of resveratrol and quercetin in BLM-induced lung damage.Aug 31, 2015

Pubmed Data : Br J Nutr. 2015 Sep ;114(6):853-865. PMID: 26334388
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Substances : Mangiferin, Quercetin, Resveratrol
Diseases : Pulmonary Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

Thymoquinone has the preventive and therapeutic potentials for the treatment of lung fibrosis.Jun 17, 2016

Pubmed Data : Environ Toxicol Pharmacol. 2016 Jun 18 ;45:340-345. Epub 2016 Jun 18. PMID: 27375216
Article Published Date : Jun 17, 2016
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Antioxidants
Additional Keywords : Gene Expression Regulation
Problem Substances : Pesticides
[+]

Treatment with taurine can effectively attenuate the pathological expression of TNF-alpha protein of lung in rats induced by silica.May 01, 2007

Pubmed Data : Wei Sheng Yan Jiu. 2007 May;36(3):364-6. PMID: 17712964
Article Published Date : May 01, 2007
Study Type : Animal Study
Additional Links
Substances : Taurine
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Vitamin D prevents experimental lung fibrosis and predicts survival in patients with idiopathic pulmonary fibrosis.Dec 31, 2018

Pubmed Data : Pulm Pharmacol Ther. 2019 04 ;55:17-24. Epub 2019 Jan 16. PMID: 30659895
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Vitamin D
Diseases : Pulmonary Fibrosis, Vitamin D Deficiency
Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator
[+]

Vtamin E is superior to pentoxifylline in protecting against radiation-induced pulmonary fibrosis in rats. May 01, 2007

Pubmed Data : Clin Oncol (R Coll Radiol). 2007 May;19(4):260-4. Epub 2007 Jan 12. PMID: 17433970
Article Published Date : May 01, 2007
Study Type : Animal Study
Additional Links
Substances : Vitamin E
Diseases : Pulmonary Fibrosis, Radiation Induced Illness: Thoracic
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

The herbicide paraquat-induced molecular mechanisms in the development of acute lung injury and lung fibrosis.Dec 31, 2020

Pubmed Data : Crit Rev Toxicol. 2021 Jan ;51(1):36-64. Epub 2021 Feb 2. PMID: 33528289
Article Published Date : Dec 31, 2020
Study Type : Review
Additional Links
Diseases : Herbicide Toxicity, Lung Injury: Acute, Pulmonary Fibrosis
[+]

A fundamental treatment goal of pulmonary fibrosis is alhpa(v)beta6-mediated Transforming growth factor (TGF)-beta suppression. Jan 01, 2008

Pubmed Data : Am J Respir Crit Care Med. 2008 Jan 1;177(1):56-65. Epub 2007 Oct 4. PMID: 17916809
Article Published Date : Jan 01, 2008
Study Type : Commentary
Additional Links
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Transforming growth factor beta (TGF-β) inhibitor
[+]

A review of carnosine and lung disease.Jul 11, 2019

Pubmed Data : Curr Med Chem. 2019 Jul 12. Epub 2019 Jul 12. PMID: 31309876
Article Published Date : Jul 11, 2019
Study Type : Review
Additional Links
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Diseases, Oxidative Stress, Pulmonary Fibrosis
Pharmacological Actions : Antioxidants
[+]

Arctigenin suppressed epithelial-mesenchymal transition through Wnt3a/β-catenin pathway in PQ-Induced pulmonary fibrosis Dec 31, 2019

Pubmed Data : Front Pharmacol. 2020 ;11:584098. Epub 2020 Dec 16. PMID: 33390951
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Arctigenin
Diseases : Pesticide Toxicity , Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic
Problem Substances : Paraquat
[+]

Artesunate restraining MAPK passage by smad7 to resist pulmonary fibrosis.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur Rev Med Pharmacol Sci. 2014 ;18(21):3199-204. PMID: 25487928
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Artesunate
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Astaxanthin attenuates pulmonary fibrosis through lncITPF and mitochondria‐mediated signal pathways.Aug 18, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2020 Aug 19. Epub 2020 Aug 19. PMID: 32813323
Article Published Date : Aug 18, 2020
Study Type : In Vitro Study
Additional Links
Substances : Astaxanthin
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Astragaloside IV alleviates silica‑induced pulmonary fibrosis.Feb 28, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2021 Mar ;47(3). Epub 2021 Jan 15. PMID: 33448318
Article Published Date : Feb 28, 2021
Study Type : In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Pulmonary Fibrosis, Silicosis
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor
[+]

Curcumin not only could inhibit TGF-β2 induced proliferation of lung fibroblasts, but also could inhibit the synthesis of collagens.Sep 30, 2015

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2015 Oct ;35(10):1249-54. PMID: 26677679
Article Published Date : Sep 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Pulmonary Fibrosis
[+]

Efficacy and safety of N-acetylcysteine therapy for idiopathic pulmonary fibrosis.Jun 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2019 Jul ;18(1):802-816. Epub 2019 May 15. PMID: 31258714
Article Published Date : Jun 30, 2019
Study Type : Review
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

EGCG inhibits neutrophil-associated damage in a pulmonary inflammation model, significantly reducing fibrosis. Apr 15, 2003

Pubmed Data : J Immunol. 2003 Apr 15;170(8):4335-41. PMID: 12682270
Article Published Date : Apr 15, 2003
Study Type : Review
Additional Links
Substances : Catechin , EGCG (Epigallocatechin gallate), Green Tea
Diseases : Inflammation, Pulmonary Fibrosis
Pharmacological Actions : Anti-Angiogenic, Anti-Inflammatory Agents
Additional Keywords : Plant Extracts
[+]

Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases.Jan 19, 2020

Pubmed Data : Chem Biol Interact. 2020 Jan 20 ;317:108947. Epub 2020 Jan 20. PMID: 31968208
Article Published Date : Jan 19, 2020
Study Type : Review
Additional Links
Substances : Berberine
Diseases : Asthma, Chronic Obstructive Pulmonary Disease, Inflammation, Lung Cancer, Pulmonary Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Ligustrazine, an alkaloid found within Ligusticum, and Red Sage (saliva m.) are more effective than hydrocortisone in reducing collagengene expression in rat pulmonary fibrosis. Jan 01, 1999

Pubmed Data : Zhonghua Jie He He Hu Xi Za Zhi. 1999 Jan;22(1):43-5. PMID: 11812356
Article Published Date : Jan 01, 1999
Study Type : In Vitro Study
Additional Links
Substances : Ligusticum wallichii , Red Sage
Diseases : Pulmonary Fibrosis
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Progress in the study of pulmonary fibrosis signaling pathways caused by paraquat poisoning.Feb 28, 2021

Pubmed Data : Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2021 Mar ;33(3):377-380. PMID: 33834986
Article Published Date : Feb 28, 2021
Study Type : Review
Additional Links
Diseases : Herbicide Toxicity, Pulmonary Fibrosis
Problem Substances : Paraquat
[+]

Puerarin regulated the proliferation and apoptosis of pulmonary fibrosis cells.Aug 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2019 Aug 31 ;25:6523-6531. Epub 2019 Aug 31. PMID: 31471534
Article Published Date : Aug 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Puerarin
Diseases : Acute Respiratory Distress Syndrome, Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Interleukin-2 Downregulation, Interleukin-4 downregulation, Transforming growth factor beta (TGF-β) inhibitor
[+]

Resveratrol may have therapeutic value in pulmonary fibrosis. Jan 26, 2011

Pubmed Data : Exp Lung Res. 2011 Jan 26. Epub 2011 Jan 26. PMID: 21269063
Article Published Date : Jan 26, 2011
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Transforming growth factor beta (TGF-β) inhibitor
[+]

Review: Molecular basis of lung tissue regeneration.Apr 01, 2011

Pubmed Data : Gen Thorac Cardiovasc Surg. 2011 Apr;59(4):231-44. Epub 2011 Apr 12. PMID: 21484549
Article Published Date : Apr 01, 2011
Study Type : Review
Additional Links
Diseases : Pulmonary Fibrosis
[+]

Salvianolic acid B and sodium tanshinone II A sulfonate prevent pulmonary fibrosis through anti-inflammatory and anti-fibrotic process.Jul 05, 2020

Pubmed Data : Eur J Pharmacol. 2020 Jul 6 ;883:173352. Epub 2020 Jul 6. PMID: 32645333
Article Published Date : Jul 05, 2020
Study Type : In Vitro Study
Additional Links
Substances : Salvia miltiorrhiza, Tanshinone IIA
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis.Dec 31, 2017

Pubmed Data : Biochem Biophys Res Commun. 2018 01 1 ;495(1):325-331. Epub 2017 Nov 4. PMID: 29108993
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Tanshinone IIA attenuates silica-induced pulmonary fibrosis.Feb 29, 2020

Pubmed Data : Chem Biol Interact. 2020 Mar 1 ;319:109024. Epub 2020 Feb 22. PMID: 32097614
Article Published Date : Feb 29, 2020
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Nrf2 activation, Transforming growth factor beta (TGF-β) inhibitor
[+]

The present study is the first to demonstrate that melatonin can protect human alveolar epithelial cells against oxidative stress.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 Dec ;132:110827. Epub 2020 Oct 13. PMID: 33065391
Article Published Date : Nov 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Lipopolysaccharide-Induced Toxicity, Pulmonary Fibrosis
Pharmacological Actions : Antioxidants, Nrf2 activation

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