Pulmonary Fibrosis: Bleomycin-Induced

Name	AC	CK
Chamomile	2	4
Crocin	2	4
Mangiferin	2	4
Nigella sativa (aka Black Seed)	2	4
Safflower	2	4
Tanshinone IIA	2	4
Thymoquinone	2	4
Resveratrol	2	3
Astragaloside	1	2
Babchi	1	2
Bee Propolis	1	2
Betulinic acid	1	2
Carnosic Acid	1	2
Celastrol	1	2
Chrysin	1	2
Curcumin	1	2
Fisetin	1	2
Flaxseed	1	2
Fucoidan	1	2
Fucoxanthin	1	2
Garlic: Aged	1	2
Ginsenosides	1	2
Gotu Kola	1	2
Grape Seed Extract	1	2
Hesperidin	1	2
Licorice	1	2
Ligustrazine	1	2
Magnolol	1	2
Myricetin	1	2
Myrtle	1	2
Oridonin	1	2
Paeoniflorin	1	2
Paeonol	1	2
Parthenolide	1	2
Quercetin	1	2
Reishi Mushroom	1	2
Rosemary	1	2
Royal Jelly	1	2
Sage	1	2
Salvia miltiorrhiza	1	2
Spermidine	1	2
Walnut	1	2
neohesperidin	1	2
Kaempferol	1	1
Mangosteen	1	1

Name	AC	CK	Focus
Bleomycin	2	4

[+]

Asiaticoside attenuates bleomycin-induced pulmonary fibrosis.Jun 29, 2020

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Pubmed Data : Biochem Biophys Res Commun. 2020 Jun 30 ;527(3):662-667. Epub 2020 May 15. PMID: 32423816

Article Published Date : Jun 29, 2020

Study Type : Animal Study

Additional Links

Substances : Gotu Kola

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents

[+]

Astragaloside IV improves bleomycin-induced pulmonary fibrosis.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2017 ;8:513. Epub 2017 Aug 8. PMID: 28848434

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents

[+]

Astragaloside IV modulates TGF‐β1‐dependent epithelial‐mesenchymal transition in bleomycin‐induced pulmonary fibrosisAug 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Cell Mol Med. 2018 Sep ;22(9):4354-4365. Epub 2018 Jul 4. PMID: 29971947

Article Published Date : Aug 31, 2018

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic

[+]

Berberine regulates pulmonary inflammatory microenvironment and decreases collagen deposition in response to bleomycin-induced pulmonary fibrosis.Nov 25, 2022

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Pubmed Data : Basic Clin Pharmacol Toxicol. 2022 Nov 26. Epub 2022 Nov 26. PMID: 36433932

Article Published Date : Nov 25, 2022

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Betulinic acid attenuated bleomycin-induced pulmonary fibrosis by effectively intervening Wnt/β-catenin signaling.Dec 31, 2020

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Pubmed Data : Phytomedicine. 2021 Jan ;81:153428. Epub 2020 Dec 1. PMID: 33341025

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Betulinic acid

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents, Wnt/β-catenin signaling pathway modulation

[+]

Both rosemary extracts administrated alone or in combination alleviated synergistically lung fibrosis.Oct 15, 2020

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Pubmed Data : Nutr Cancer. 2020 Oct 16:1-12. Epub 2020 Oct 16. PMID: 33059466

Article Published Date : Oct 15, 2020

Study Type : Animal Study

Additional Links

Substances : Carnosic Acid, Rosemary

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents

Additional Keywords : Natural Substance Synergy

[+]

Celastrol is a novel selective agonist of cannabinoid receptor 2 with anti-inflammatory and anti-fibrotic activity in a mouse model of systemic sclerosis.Jan 31, 2020

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Pubmed Data : Phytomedicine. 2020 Feb ;67:153160. Epub 2019 Dec 26. PMID: 31901889

Article Published Date : Jan 31, 2020

Study Type : Animal Study

Additional Links

Substances : Celastrol

Diseases : Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents

[+]

Chamomile hydroalcoholic extract may be able to diminish the toxic effects of bleomycin on the lung tissues.Sep 30, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Tanaffos. 2018 Oct ;17(4):264-271. PMID: 31143217

Article Published Date : Sep 30, 2018

Study Type : Animal Study

Additional Links

Substances : Chamomile

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic

[+]

Chrysin mitigates bleomycin-induced pulmonary fibrosis.Oct 08, 2020

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Pubmed Data : Int Immunopharmacol. 2020 Oct 9 ;89(Pt A):107011. Epub 2020 Oct 9. PMID: 33045575

Article Published Date : Oct 08, 2020

Study Type : Animal Study

Additional Links

Substances : Chrysin

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Crocin attenuates lung inflammation and pulmonary vascular dysfunction in a rat model of bleomycin-induced pulmonary fibrosis.Aug 25, 2019

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Pubmed Data : Life Sci. 2019 Aug 26:116794. Epub 2019 Aug 26. PMID: 31465731

Article Published Date : Aug 25, 2019

Study Type : Animal Study

Additional Links

Substances : Crocin

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Crocin: a protective natural antioxidant against pulmonary fibrosis induced by bleomycin.Jan 28, 2020

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Pubmed Data : Pharmacol Rep. 2020 Jan 29. Epub 2020 Jan 29. PMID: 31997260

Article Published Date : Jan 28, 2020

Study Type : Animal Study

Additional Links

Substances : Crocin

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Chemoprotective Agents

[+]

Curcumin was beneficial in acute lung injury and lung fibrosis.Aug 22, 2019

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Pubmed Data : Endocr Metab Immune Disord Drug Targets. 2019 Aug 23. Epub 2019 Aug 23. PMID: 31441735

Article Published Date : Aug 22, 2019

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Lung Injury: Acute, Pulmonary Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic

[+]

Danshensu alleviates bleomycin-induced pulmonary fibrosis.Nov 30, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Bioengineered. 2021 Dec ;12(1):3113-3124. PMID: 34187349

Article Published Date : Nov 30, 2021

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Salvia miltiorrhiza

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic

[+]

Dietary flaxseed oil protects against bleomycin-induced pulmonary fibrosis in rats.Dec 31, 2011

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Pubmed Data : Pulm Med. 2012 ;2012:457031. Epub 2012 Aug 8. PMID: 22919480

Article Published Date : Dec 31, 2011

Study Type : Animal Study

Additional Links

Substances : Flaxseed

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis: Bleomycin-Induced

Problem Substances : Bleomycin

[+]

Fisetin alleviated bleomycin-induced pulmonary fibrosis.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2020 ;11:553690. Epub 2020 Dec 14. PMID: 33381023

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Fisetin

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents

[+]

Fucoxanthin inhibits profibrotic protein expression in vitro and attenuates bleomycin-induced lung fibrosis in vivo.Sep 14, 2017

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Pubmed Data : Eur J Pharmacol. 2017 Sep 15 ;811:199-207. Epub 2017 Jun 19. PMID: 28642129

Article Published Date : Sep 14, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Fucoxanthin

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic

[+]

G. glabra may be suggested for the prevention and treatment of pulmonary fibrosis and inflammation.May 08, 2019

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Pubmed Data : Drug Chem Toxicol. 2019 May 9:1-7. Epub 2019 May 9. PMID: 31072167

Article Published Date : May 08, 2019

Study Type : Animal Study

Additional Links

Substances : Licorice

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Malondialdehyde Down-regulation

[+]

Glycyrrhizic acid inhibits core fucosylation modification modulated EMT and attenuates bleomycin-induced pulmonary fibrosis.Dec 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:5943322. Epub 2022 Jul 6. PMID: 35845568

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Glycyrrhizin

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents

[+]

Grape seed extracts may improve the quality of life of lung fibrosis patients by inhibiting MMP-9 and TGF-β1 expression in the lungs.Mar 11, 2017

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Pubmed Data : Toxicol Lett. 2017 Mar 12 ;273:1-9. Epub 2017 Mar 12. PMID: 28300665

Article Published Date : Mar 11, 2017

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Hesperidin ameliorates bleomycin-induced experimental pulmonary fibrosis.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : EXCLI J. 2019 ;18:723-745. Epub 2019 Aug 29. PMID: 31611754

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Hydroxysafflor yellow A attenuates bleomycin-induced pulmonary fibrosis.Mar 31, 2016

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2016 Apr ;30(4):577-87. Epub 2016 Jan 18. PMID: 26777519

Article Published Date : Mar 31, 2016

Study Type : Animal Study

Additional Links

Substances : Safflower

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents

[+]

Hyperoside attenuates bleomycin-induced pulmonary fibrosis development.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2020 ;11:550955. Epub 2020 Oct 22. PMID: 33192501

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Chemoprotective Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Icariin attenuates bleomycin-induced pulmonary fibrosis by targeting Hippo/YAP pathway.Oct 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2021 Nov ;143:112152. Epub 2021 Sep 15. PMID: 34536758

Article Published Date : Oct 31, 2021

Study Type : Animal Study

Additional Links

Substances : Icariin

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents

[+]

Inhibitory effects of total ginsenoside on bleomycin-induced pulmonary fibrosis in mice.May 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2019 Jun ;114:108851. Epub 2019 Apr 6. PMID: 30965234

Article Published Date : May 31, 2019

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents

[+]

Juglanin alleviates bleomycin-induced lung injury.Jun 30, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2020 Jul ;127:110119. Epub 2020 Apr 7. PMID: 32276127

Article Published Date : Jun 30, 2020

Study Type : Animal Study

Additional Links

Substances : Walnut

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents

[+]

Low-molecular-weight fucoidan attenuates bleomycin-induced pulmonary fibrosis.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Transl Res. 2019 ;11(4):2590-2602. Epub 2019 Apr 15. PMID: 31105865

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Fucoidan

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents

[+]

Magnolol might be a potent anti-inflammatory and anti-fibrotic agent against bleomycin-induced lung fibrosis.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Clin Exp Med. 2015 ;8(9):15450-7. Epub 2015 Sep 15. PMID: 26629034

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Magnolol

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Mangiferin attenuates bleomycin-induced pulmonary fibrosis.Mar 06, 2019

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Pubmed Data : J Pharm Pharmacol. 2019 Mar 7. Epub 2019 Mar 7. PMID: 30847938

Article Published Date : Mar 06, 2019

Study Type : Animal Study

Additional Links

Substances : Mangiferin

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic

[+]

Myrtle extract effectively inhibited the inflammation and fibrosis of lung parenchyma in both preventive and therapeutic methods.Sep 30, 2018

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Pubmed Data : Drug Chem Toxicol. 2018 Oct ;41(4):408-414. Epub 2018 May 11. PMID: 29747538

Article Published Date : Sep 30, 2018

Study Type : Animal Study

Additional Links

Substances : Myrtle

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Prophylactic Agents

[+]

N. Sativa extract is effective for early and late prevention of pulmonary fibrosis and inflammation. Apr 30, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Avicenna J Phytomed. 2018 May-Jun;8(3):263-275. PMID: 29881712

Article Published Date : Apr 30, 2018

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic

[+]

Neohesperidin inhibits TGF-β1/Smad3 signaling and alleviates bleomycin-induced pulmonary fibrosis in mice.Nov 30, 2019

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2019 Dec 1 ;864:172712. Epub 2019 Oct 2. PMID: 31586469

Article Published Date : Nov 30, 2019

Study Type : Animal Study

Additional Links

Substances : neohesperidin

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents, Transforming growth factor beta (TGF-β) inhibitor

[+]

Nigella sativa oil treatment attenuated the effects of bleomycin induced pulmonary fibrosis.Apr 12, 2017

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Pubmed Data : Biomed Pharmacother. 2017 Apr 13 ;90:626-637. Epub 2017 Apr 13. PMID: 28412654

Article Published Date : Apr 12, 2017

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents

[+]

Oridonin inhibits myofibroblast differentiation and bleomycin-induced pulmonary fibrosis.Oct 21, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Med Sci Monit. 2018 Oct 22 ;24:7548-7555. Epub 2018 Oct 22. PMID: 30347408

Article Published Date : Oct 21, 2018

Study Type : Animal Study

Additional Links

Substances : Oridonin

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor

[+]

Paeoniflorin attenuates pulmonary fibrosis by suppressing type I collagen synthesis.Oct 06, 2013

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Pubmed Data : J Ethnopharmacol. 2013 Oct 7 ;149(3):825-32. Epub 2013 Aug 22. PMID: 23973787

Article Published Date : Oct 06, 2013

Study Type : Animal Study

Additional Links

Substances : Paeoniflorin

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents

[+]

Parthenolide attenuated bleomycin-induced pulmonary fibrosis.Jan 04, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Respir Res. 2018 06 5 ;19(1):111. Epub 2018 Jun 5. PMID: 29871641

Article Published Date : Jan 04, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Parthenolide

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Polysaccharides from Ganoderma lucidum played a positive protective role in the pulmonary fibrosis.Oct 31, 2016

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Pubmed Data : Int J Biol Macromol. 2016 Nov ;92:278-281. Epub 2016 Aug 2. PMID: 27381587

Article Published Date : Oct 31, 2016

Study Type : Animal Study

Additional Links

Substances : Reishi Mushroom

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Glutathione Upregulation , Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation

Additional Keywords : Polysaccharides

[+]

Prevention of bleomycin-induced pulmonary inflammation and fibrosis in mice by paeonol.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Physiol. 2017 ;8:193. Epub 2017 Mar 31. PMID: 28408888

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Paeonol

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants

[+]

Propolis has protective effects against bleomycin induced pulmonary fibrosis.Feb 29, 2016

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Pubmed Data : Biotech Histochem. 2016 Mar ;91(3):195-203. Epub 2016 Mar 9. PMID: 26960158

Article Published Date : Feb 29, 2016

Study Type : Animal Study

Additional Links

Substances : Bee Propolis

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents

[+]

Protective and therapeutic effects of ethanolic extract of watercress and vitamin E against bleomycin-induced pulmonary fibrosis.Jan 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Res Pharm Sci. 2021 Feb ;16(1):94-102. Epub 2020 Dec 30. PMID: 33953778

Article Published Date : Jan 31, 2021

Study Type : Animal Study

Additional Links

Substances : Garden Cress (Lepidium sativum) , Vitamin E, Watercress

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents

[+]

Protective effect of Eucalyptus globulus extracts against bleomycin-induced pulmonary fibrosis.Jun 30, 2022

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Pubmed Data : J Med Food. 2022 Jul ;25(7):741-750. PMID: 35834630

Article Published Date : Jun 30, 2022

Study Type : Animal Study

Additional Links

Substances : Eucalyptus

Diseases : Oxidative Stress, Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Catalase Up-Regulation, Chemoprotective Agents, Superoxide Dismutase Up-regulation

[+]

Protective effect of hydroxysafflor yellow A on bleomycin- induced pulmonary inflammation and fibrosis.Dec 31, 2017

Click here to read the entire abstract

Pubmed Data : Chin J Integr Med. 2018 Jan ;24(1):32-39. Epub 2018 Jan 3. PMID: 29294256

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Safflower

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Protective effects of lotus plumule ethanol extracts on bleomycin-induced pulmonary fibrosis.Nov 01, 2021

Click here to read the entire abstract

Pubmed Data : Drug Chem Toxicol. 2021 Nov 2:1-10. Epub 2021 Nov 2. PMID: 34724865

Article Published Date : Nov 01, 2021

Study Type : Animal Study

Additional Links

Substances : Lotus

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic

[+]

Psoralen attenuates bleomycin-induced pulmonary fibrosis.Jul 21, 2019

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Pubmed Data : Cell Biol Int. 2019 Jul 22. Epub 2019 Jul 22. PMID: 31329322

Article Published Date : Jul 21, 2019

Study Type : Animal Study

Additional Links

Substances : Babchi

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents

[+]

Royal jelly attenuates oxidative damage and fibrosis induced by bleomycin.Jul 20, 2016

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Pubmed Data : Can J Physiol Pharmacol. 2016 Jul 21:1-9. Epub 2016 Jul 21. PMID: 27841941

Article Published Date : Jul 20, 2016

Study Type : Animal Study

Additional Links

Substances : Royal Jelly

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

Problem Substances : Bleomycin

[+]

S-allyl cysteine may be useful for the prevention or treatment of pulmonary fibrosis.Mar 28, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2017 Mar 29 ;22(4). Epub 2017 Mar 29. PMID: 28353632

Article Published Date : Mar 28, 2017

Study Type : Animal Study

Additional Links

Substances : Garlic: Aged

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic

[+]

Salvia miltiorrhiza and ligustrazine is safe and effective in repressing BLM-induced pulmonary fibrosis.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Chin Med. 2018 ;13:36. Epub 2018 Jul 4. PMID: 29997685

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Ligustrazine, Salvia miltiorrhiza

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Salvia officinalis attenuates bleomycin-induced oxidative stress and lung fibrosis in rats.Oct 11, 2019

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2019 Oct 12:1-11. Epub 2019 Oct 12. PMID: 31608667

Article Published Date : Oct 11, 2019

Study Type : Animal Study

Additional Links

Substances : Sage

Diseases : Oxidative Stress, Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Antioxidants

[+]

Spermidine attenuates bleomycin-induced lung fibrosis.Nov 30, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Mol Med. 2020 Dec ;52(12):2034-2045. Epub 2020 Dec 14. PMID: 33318630

Article Published Date : Nov 30, 2020

Study Type : Animal Study

Additional Links

Substances : Spermidine

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Autophagy Up-regulation, Chemoprotective Agents

[+]

Tanshinone IIA ameliorates the bleomycin-induced endothelial-to-mesenchymal transition.Nov 30, 2019

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Pubmed Data : Int Immunopharmacol. 2019 Dec ;77:105968. Epub 2019 Nov 6. PMID: 31704290

Article Published Date : Nov 30, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Pulmonary Fibrosis: Bleomycin-Induced, Scleroderma: Systemic

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents

[+]

Tanshinone IIA attenuates bleomycin-induced pulmonary fibrosis.Dec 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Med Sci. 2014 ;11(6):578-86. Epub 2014 Apr 7. PMID: 24782646

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Inflammation, Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic

[+]

These findings confirmed the anti-inflammatory effects of resveratrol and quercetin in BLM-induced lung damage.Aug 31, 2015

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Pubmed Data : Br J Nutr. 2015 Sep ;114(6):853-865. PMID: 26334388

Article Published Date : Aug 31, 2015

Study Type : Animal Study

Additional Links

Substances : Mangiferin, Quercetin, Resveratrol

Diseases : Pulmonary Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors

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Thymoquinone can be developed as a potential therapeutic modularity in bleomycin-induced lung fibrosis for human use.Feb 12, 2020

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Pubmed Data : Exp Lung Res. 2020 Feb 13:1-11. Epub 2020 Feb 13. PMID: 32053036

Article Published Date : Feb 12, 2020

Study Type : Animal Study

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Substances : Thymoquinone

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation

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Thymoquinone-PLGA-PVA nanoparticles ameliorate bleomycin-induced pulmonary fibrosis.Nov 10, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Animals (Basel). 2019 Nov 11 ;9(11). Epub 2019 Nov 11. PMID: 31717986

Article Published Date : Nov 10, 2019

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

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Alpha-mangostin ameliorates bleomycin-induced pulmonary fibrosis.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2019 ;10:1305. Epub 2019 Nov 13. PMID: 31798444

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Mangosteen

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Antioxidants

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Andrographolide can reduce bleomycin-induced pulmonary ﬁbrosis.Apr 30, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Ann Transl Med. 2021 May ;9(9):764. PMID: 34268377

Article Published Date : Apr 30, 2021

Study Type : In Vitro Study

Additional Links

Substances : Andrographolide

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Chemoprotective Agents

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Blueberry juice attenuates pulmonary fibrosis via blocking the TGF-β1/Smad signaling pathway.Dec 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2022 ;13:825915. Epub 2022 Mar 28. PMID: 35418869

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Blueberry

Diseases : Pulmonary Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Transforming growth factor beta (TGF-β) inhibitor

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Kaempferol might improve bleomycin-induced fibrosis by reducing oxidative stress, inflammation, and oxidative cellular damage.Sep 30, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Dermatol Sci. 2019 Oct ;96(1):8-17. Epub 2019 Aug 16. PMID: 31447184

Article Published Date : Sep 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Kaempferol

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Nimbolide as a potent anti-fibrotic agent.Sep 30, 2019

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Pubmed Data : Int Immunopharmacol. 2019 Oct ;75:105755. Epub 2019 Aug 1. PMID: 31377591

Article Published Date : Sep 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Neem

Diseases : Pulmonary Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents

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Resveratrol inhibits pulmonary fibrosis by regulating miR-21 through MAPK/AP-1 pathways.May 25, 2018

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Pubmed Data : Biomed Pharmacother. 2018 May 26 ;105:37-44. Epub 2018 May 26. PMID: 29843043

Article Published Date : May 25, 2018

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator

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View the Evidence: 62 Abstracts with Pulmonary Fibrosis: Bleomycin-Induced Research

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Myricetin ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-β signaling via targeting HSP90β.Jun 10, 2020

A combination of Chamomile and Anthocyanoside lead to a significant reduction in Bleomycin-induced MDA.Jul 31, 2015

Ameliorative effects of arctigenin on pulmonary fibrosis induced by bleomycin via the antioxidant activity.Dec 31, 2021

Asiaticoside attenuates bleomycin-induced pulmonary fibrosis.Jun 29, 2020

Astragaloside IV improves bleomycin-induced pulmonary fibrosis.Dec 31, 2016

Astragaloside IV modulates TGF‐β1‐dependent epithelial‐mesenchymal transition in bleomycin‐induced pulmonary fibrosisAug 31, 2018

Berberine regulates pulmonary inflammatory microenvironment and decreases collagen deposition in response to bleomycin-induced pulmonary fibrosis.Nov 25, 2022

Betulinic acid attenuated bleomycin-induced pulmonary fibrosis by effectively intervening Wnt/β-catenin signaling.Dec 31, 2020

Both rosemary extracts administrated alone or in combination alleviated synergistically lung fibrosis.Oct 15, 2020

Celastrol is a novel selective agonist of cannabinoid receptor 2 with anti-inflammatory and anti-fibrotic activity in a mouse model of systemic sclerosis.Jan 31, 2020

Chamomile hydroalcoholic extract may be able to diminish the toxic effects of bleomycin on the lung tissues.Sep 30, 2018

Chrysin mitigates bleomycin-induced pulmonary fibrosis.Oct 08, 2020

Crocin attenuates lung inflammation and pulmonary vascular dysfunction in a rat model of bleomycin-induced pulmonary fibrosis.Aug 25, 2019

Crocin: a protective natural antioxidant against pulmonary fibrosis induced by bleomycin.Jan 28, 2020

Curcumin was beneficial in acute lung injury and lung fibrosis.Aug 22, 2019

Danshensu alleviates bleomycin-induced pulmonary fibrosis.Nov 30, 2021

Dietary flaxseed oil protects against bleomycin-induced pulmonary fibrosis in rats.Dec 31, 2011

Fisetin alleviated bleomycin-induced pulmonary fibrosis.Dec 31, 2019

Fucoxanthin inhibits profibrotic protein expression in vitro and attenuates bleomycin-induced lung fibrosis in vivo.Sep 14, 2017

G. glabra may be suggested for the prevention and treatment of pulmonary fibrosis and inflammation.May 08, 2019

Glycyrrhizic acid inhibits core fucosylation modification modulated EMT and attenuates bleomycin-induced pulmonary fibrosis.Dec 31, 2021

Grape seed extracts may improve the quality of life of lung fibrosis patients by inhibiting MMP-9 and TGF-β1 expression in the lungs.Mar 11, 2017

Hesperidin ameliorates bleomycin-induced experimental pulmonary fibrosis.Dec 31, 2018

Hydroxysafflor yellow A attenuates bleomycin-induced pulmonary fibrosis.Mar 31, 2016

Hyperoside attenuates bleomycin-induced pulmonary fibrosis development.Dec 31, 2019

Icariin attenuates bleomycin-induced pulmonary fibrosis by targeting Hippo/YAP pathway.Oct 31, 2021

Inhibitory effects of total ginsenoside on bleomycin-induced pulmonary fibrosis in mice.May 31, 2019

Juglanin alleviates bleomycin-induced lung injury.Jun 30, 2020

Low-molecular-weight fucoidan attenuates bleomycin-induced pulmonary fibrosis.Dec 31, 2018

Magnolol might be a potent anti-inflammatory and anti-fibrotic agent against bleomycin-induced lung fibrosis.Dec 31, 2014

Mangiferin attenuates bleomycin-induced pulmonary fibrosis.Mar 06, 2019

Myrtle extract effectively inhibited the inflammation and fibrosis of lung parenchyma in both preventive and therapeutic methods.Sep 30, 2018

N. Sativa extract is effective for early and late prevention of pulmonary fibrosis and inflammation. Apr 30, 2018

Neohesperidin inhibits TGF-β1/Smad3 signaling and alleviates bleomycin-induced pulmonary fibrosis in mice.Nov 30, 2019

Nigella sativa oil treatment attenuated the effects of bleomycin induced pulmonary fibrosis.Apr 12, 2017

Oridonin inhibits myofibroblast differentiation and bleomycin-induced pulmonary fibrosis.Oct 21, 2018

Paeoniflorin attenuates pulmonary fibrosis by suppressing type I collagen synthesis.Oct 06, 2013

Parthenolide attenuated bleomycin-induced pulmonary fibrosis.Jan 04, 2018

Polysaccharides from Ganoderma lucidum played a positive protective role in the pulmonary fibrosis.Oct 31, 2016

Prevention of bleomycin-induced pulmonary inflammation and fibrosis in mice by paeonol.Dec 31, 2016

Propolis has protective effects against bleomycin induced pulmonary fibrosis.Feb 29, 2016

Protective and therapeutic effects of ethanolic extract of watercress and vitamin E against bleomycin-induced pulmonary fibrosis.Jan 31, 2021

Protective effect of Eucalyptus globulus extracts against bleomycin-induced pulmonary fibrosis.Jun 30, 2022

Protective effect of hydroxysafflor yellow A on bleomycin- induced pulmonary inflammation and fibrosis.Dec 31, 2017

Protective effects of lotus plumule ethanol extracts on bleomycin-induced pulmonary fibrosis.Nov 01, 2021

Psoralen attenuates bleomycin-induced pulmonary fibrosis.Jul 21, 2019

Royal jelly attenuates oxidative damage and fibrosis induced by bleomycin.Jul 20, 2016

S-allyl cysteine may be useful for the prevention or treatment of pulmonary fibrosis.Mar 28, 2017

Salvia miltiorrhiza and ligustrazine is safe and effective in repressing BLM-induced pulmonary fibrosis.Dec 31, 2017

Salvia officinalis attenuates bleomycin-induced oxidative stress and lung fibrosis in rats.Oct 11, 2019

Spermidine attenuates bleomycin-induced lung fibrosis.Nov 30, 2020

Tanshinone IIA ameliorates the bleomycin-induced endothelial-to-mesenchymal transition.Nov 30, 2019

Tanshinone IIA attenuates bleomycin-induced pulmonary fibrosis.Dec 31, 2013

These findings confirmed the anti-inflammatory effects of resveratrol and quercetin in BLM-induced lung damage.Aug 31, 2015

Thymoquinone can be developed as a potential therapeutic modularity in bleomycin-induced lung fibrosis for human use.Feb 12, 2020

Thymoquinone-PLGA-PVA nanoparticles ameliorate bleomycin-induced pulmonary fibrosis.Nov 10, 2019

Alpha-mangostin ameliorates bleomycin-induced pulmonary fibrosis.Dec 31, 2018

Andrographolide can reduce bleomycin-induced pulmonary ﬁbrosis.Apr 30, 2021

Blueberry juice attenuates pulmonary fibrosis via blocking the TGF-β1/Smad signaling pathway.Dec 31, 2021

Kaempferol might improve bleomycin-induced fibrosis by reducing oxidative stress, inflammation, and oxidative cellular damage.Sep 30, 2019

Nimbolide as a potent anti-fibrotic agent.Sep 30, 2019

Resveratrol inhibits pulmonary fibrosis by regulating miR-21 through MAPK/AP-1 pathways.May 25, 2018

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Pulmonary Fibrosis: Bleomycin-Induced

View the Evidence:
62 Abstracts with Pulmonary Fibrosis: Bleomycin-Induced Research