Rhinosinusitis

Name	AC	CK
Vitamin D	3	40
Pelargonium sidoides	2	30
Nigella sativa (aka Black Seed)	3	22
Manuka Honey	3	21
Chamomile	1	10
Homeopathic Medicine: All	1	10
Nattokinase	1	10
Vitamin C	1	10
Xylitol	1	10
Apigenin	1	5
Colloidal Silver	1	2
Elderberry	1	2
Flavonoids	1	2
Lactobacillus casei	1	2
NAC (N-acetyl-L-cysteine)	1	2
Savory	1	2
Ginseng (Korean)	1	1
Hydrogen Peroxide	1	1

Name	AC	CK	Focus
Antibiotics	1	10

Name	AC	CK
Nasal Irrigation	4	41
Homeopathic Treatment	1	10
Integrative Medicine	1	10
Reflexology	1	10
Yogic Breathing	1	10
Photodynamic therapy	2	6

[+]

Association between serum vitamin D and chronic rhinosinusitis: a meta-analysis.Oct 02, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Braz J Otorhinolaryngol. 2019 Oct 3. Epub 2019 Oct 3. PMID: 31653607

Article Published Date : Oct 02, 2019

Study Type : Meta Analysis

Additional Links

Substances : Vitamin D

Diseases : Rhinosinusitis, Vitamin D Deficiency

Additional Keywords : Risk Factors

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Nasal saline irrigations for the symptoms of chronic rhinosinusitis are well tolerated and beneficial.Jan 01, 2007

Click here to read the entire abstract

Pubmed Data : Cochrane Database Syst Rev. 2007(3):CD006394. Epub 2007 Jul 18. PMID: 17636843

Article Published Date : Jan 01, 2007

Study Type : Meta Analysis

Additional Links

Diseases : Rhinosinusitis

Therapeutic Actions : Nasal Irrigation

[+]

P. sidoides might offer symptom relief in acute bronchitis, rhinosinusitis and the common cold.Oct 21, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cochrane Database Syst Rev. 2013 Oct 22(10):CD006323. Epub 2013 Oct 22. PMID: 24146345

Article Published Date : Oct 21, 2013

Study Type : Meta Analysis, Review

Additional Links

Substances : Pelargonium sidoides

Diseases : Bronchitis, Common Cold, Rhinosinusitis, Upper Respiratory Infections

Pharmacological Actions : Anti-Bacterial Agents, Antiviral Agents

Additional Keywords : Phytotherapy, Plant Extracts

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A homeopathic remedy appears effective and tolerable treatment of acute rhinosinusitis.Apr 01, 2007

Click here to read the entire abstract

Pubmed Data : HNO. 2007 Apr;55(4):271-7. PMID: 17180695

Article Published Date : Apr 01, 2007

Study Type : Human Study

Additional Links

Substances : Homeopathic Medicine: All

Diseases : Rhinosinusitis

Therapeutic Actions : Homeopathic Treatment

[+]

Antibiotics have only modest efficacy (1 in 8) in treating persistent nasal discharge (rhinosinusitis) in children.Jan 01, 2008

Click here to read the entire abstract

Pubmed Data : Cochrane Database Syst Rev. 2008(2):CD001094. Epub 2008 Apr 16. PMID: 18425867

Article Published Date : Jan 01, 2008

Study Type : Human Study

Additional Links

Diseases : Childhood Infections, Rhinosinusitis

Problem Substances : Antibiotics

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Chamomile extract is effective in further reducing the clinical symptoms and improving the quality of life of chronic rhinosinusitis patients.Sep 27, 2020

Click here to read the entire abstract

Pubmed Data : Am J Otolaryngol. 2020 Sep 28 ;42(1):102743. Epub 2020 Sep 28. PMID: 33038782

Article Published Date : Sep 27, 2020

Study Type : Human Study

Additional Links

Substances : Chamomile

Diseases : Rhinosinusitis

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Effects of Nigella sativa extract on chronic rhinosinusitis.Nov 30, 2021

Click here to read the entire abstract

Pubmed Data : Indian J Otolaryngol Head Neck Surg. 2021 Dec ;73(4):455-460. Epub 2021 Jan 2. PMID: 34722227

Article Published Date : Nov 30, 2021

Study Type : Human Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Rhinosinusitis

Pharmacological Actions : Anti-Bacterial Agents

[+]

Integrating regular Bhramari pranayama along with the conventional treatment of chronic rhinosinusitis is more effective than conventional treatment alone.Apr 30, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Yoga. 2019 May-Aug;12(2):120-123. PMID: 31143019

Article Published Date : Apr 30, 2019

Study Type : Human Study

Additional Links

Diseases : Rhinosinusitis

Therapeutic Actions : Integrative Medicine, Yogic Breathing

[+]

L-ascorbate may offer potential as a therapeutic agent for the improvement of chronic rhinosinusitis in patients with cystic fibrosis. May 01, 2009

Click here to read the entire abstract

Pubmed Data : Am J Rhinol Allergy. 2009 May-Jun;23(3):294-9. PMID: 19490804

Article Published Date : May 01, 2009

Study Type : Human Study

Additional Links

Substances : Vitamin C

Diseases : Cystic Fibrosis, Rhinosinusitis

[+]

Manuka honey may be effective for acute exacerbations of chronic rhinosinusitis.Dec 08, 2016

Click here to read the entire abstract

Pubmed Data : Int Forum Allergy Rhinol. 2016 Dec 9. Epub 2016 Dec 9. PMID: 27935259

Article Published Date : Dec 08, 2016

Study Type : Human Study

Additional Links

Substances : Manuka Honey

Diseases : Rhinosinusitis

[+]

Manuka honey versus saline sinus irrigation in the treatment of cystic fibrosis-associated chronic rhinosinusitis.Aug 26, 2020

Click here to read the entire abstract

Pubmed Data : Clin Otolaryngol. 2020 Aug 27. Epub 2020 Aug 27. PMID: 32852889

Article Published Date : Aug 26, 2020

Study Type : Human Study

Additional Links

Substances : Manuka Honey

Diseases : Cystic Fibrosis, Rhinosinusitis

[+]

Nattokinase effectively shrinks the nasal polyp tissue through fibrin degradation.Sep 30, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Allergol Int. 2017 Oct ;66(4):594-602. Epub 2017 Apr 4. PMID: 28389065

Article Published Date : Sep 30, 2017

Study Type : Human Study

Additional Links

Substances : Nattokinase

Diseases : Rhinosinusitis

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Pelargonium sidoides (umka) is well-tolerated and effective in the treatment of acute rhinosinusitis of presumably bacterial origin. Feb 01, 1985

Click here to read the entire abstract

Pubmed Data : Br J Exp Pathol. 1985 Feb;66(1):35-46. PMID: 19382496

Article Published Date : Feb 01, 1985

Study Type : Human Study

Additional Links

Substances : Pelargonium sidoides

Diseases : Rhinosinusitis, Sinusitis

[+]

Reflexology for acute rhinosinusitis.Dec 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Explore (NY). 2023 ;19(1):36-41. Epub 2022 Aug 6. PMID: 35961842

Article Published Date : Dec 31, 2022

Study Type : Human Study

Additional Links

Diseases : Rhinosinusitis, Sinusitis

Therapeutic Actions : Reflexology

[+]

Saline nasal irrigation is efficacious for chronic sinonasal symptoms.Jul 01, 2005

Click here to read the entire abstract

Pubmed Data : Otolaryngol Head Neck Surg. 2005 Jul;133(1):3-8. PMID: 16025044

Article Published Date : Jul 01, 2005

Study Type : Human Study

Additional Links

Diseases : Rhinosinusitis, Sinusitis

Therapeutic Actions : Nasal Irrigation

[+]

The role of oral vitamin D3 supplementation in the treatment of Chronic Rhinosinusitis in adults with Vitamin D deficiency.May 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Family Med Prim Care. 2020 Jun ;9(6):2877-2879. Epub 2020 Jun 30. PMID: 32984142

Article Published Date : May 31, 2020

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Rhinosinusitis, Vitamin C Deficiency

Pharmacological Actions : Immunomodulatory

[+]

The use of N. sativa nasal spray has symptom reliever effect with no adverse effects in patients.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Allergy Rhinol (Providence). 2018 Jan-Dec;9:2152656718800059. Epub 2018 Oct 4. PMID: 30370173

Article Published Date : Dec 31, 2017

Study Type : Human Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Rhinosinusitis

Additional Keywords : Significant Treatment Outcome

[+]

These results demonstrated better clinical and antimicrobial efficacy of EPs 7630 than amoxicillin.Sep 30, 2020

Click here to read the entire abstract

Pubmed Data : Ann Otol Rhinol Laryngol. 2020 Oct ;129(10):969-976. Epub 2020 May 26. PMID: 32456442

Article Published Date : Sep 30, 2020

Study Type : Human Study

Additional Links

Diseases : Rhinosinusitis

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Superiority of Natural Substances versus Drugs

[+]

These results suggest an important mechanism of susceptibility to rhinitis and rhinosinusitis in highly PM2.5-polluted areas.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Allergy Asthma Immunol Res. 2020 Jan ;12(1):56-71. PMID: 31743964

Article Published Date : Dec 31, 2019

Study Type : Human Study

Additional Links

Diseases : Air Pollution Linked Toxicity, Rhinitis, Rhinosinusitis

Additional Keywords : Risk Factors

[+]

Vitamin D has a protective effect against developing sinusitis.Aug 31, 2017

Click here to read the entire abstract

Pubmed Data : Eur Arch Otorhinolaryngol. 2017 Sep ;274(9):3391-3395. Epub 2017 Jun 12. PMID: 28608241

Article Published Date : Aug 31, 2017

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Rhinosinusitis, Sinusitis, Vitamin D Deficiency

Additional Keywords : Increased Risk

[+]

Xylitol nasal irrigation is effective and superior to saline irrigation in the management of chronic rhinosinusitisNov 01, 2011

Click here to read the entire abstract

Pubmed Data : Laryngoscope. 2011 Nov ;121(11):2468-72. Epub 2011 Oct 12. PMID: 21994147

Article Published Date : Nov 01, 2011

Study Type : Human Study

Additional Links

Substances : Xylitol

Diseases : Rhinosinusitis

Therapeutic Actions : Nasal Irrigation

[+]

5-Aminolevulinic acid mediated PDT on multi-antibiotic-resistant S. aureus and S. epidermidis from CRS patients was effective in vitro.Mar 06, 2016

Click here to read the entire abstract

Pubmed Data : Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Mar 7 ;51(3):164-8. PMID: 27033568

Article Published Date : Mar 06, 2016

Study Type : Human In Vitro

Additional Links

Diseases : Infection: Antibiotic Resistant, Rhinosinusitis, Staphylococcus aureus infection, Staphylococcus epidermidis

Therapeutic Actions : Photodynamic therapy

Pharmacological Actions : Anti-Bacterial Agents

[+]

These results suggests the possible use of apigenin as a chronic rhinosinusitis therapeutic agent which can suppress tissue remodelling in nasal mucosa.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2018 ;13(8):e0201595. Epub 2018 Aug 30. PMID: 30161164

Article Published Date : Dec 31, 2017

Study Type : Human In Vitro

Additional Links

Substances : Apigenin

Diseases : Rhinosinusitis

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Baicalin ameliorates inflammatory response in a mouse model of rhinosinusitis.Jan 27, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Ear Nose Throat J. 2021 Jan 28:145561320986058. Epub 2021 Jan 28. PMID: 33507111

Article Published Date : Jan 27, 2021

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Rhinosinusitis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory

[+]

Intranasal application of NAC can decrease the inflammatory findings in murine acute rhinosinusitis.Jun 02, 2022

Click here to read the entire abstract

Pubmed Data : ORL J Otorhinolaryngol Relat Spec. 2022 Jun 3:1-6. Epub 2022 Jun 3. PMID: 35661091

Article Published Date : Jun 02, 2022

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Rhinosinusitis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation

[+]

Lacticaseibacillus casei AMBR2 restores airway epithelial integrity in chronic rhinosinusitis.Jun 30, 2021

Click here to read the entire abstract

Pubmed Data : Allergy Asthma Immunol Res. 2021 Jul ;13(4):560-575. PMID: 34212544

Article Published Date : Jun 30, 2021

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Lactobacillus casei

Diseases : Rhinosinusitis

Pharmacological Actions : Anti-Inflammatory Agents

[+]

N. sativa could be used in the treatment of rhinosinusitis diseases.Jan 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Acta Otorhinolaryngol Ital. 2017 Feb ;37(1):32-37. PMID: 28374868

Article Published Date : Jan 31, 2017

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Rhinosinusitis

Pharmacological Actions : Nitric Oxide Inhibitor

[+]

Sheep treated with silver showed a significant decrease in biofilm biomass.Mar 31, 2015

Click here to read the entire abstract

Pubmed Data : Int Forum Allergy Rhinol. 2015 Apr ;5(4):283-8. Epub 2015 Jan 30. PMID: 25643830

Article Published Date : Mar 31, 2015

Study Type : Animal Study

Additional Links

Substances : Colloidal Silver

Diseases : Rhinosinusitis, Staphylococcus aureus infection

Pharmacological Actions : Anti-Bacterial Agents

[+]

The impact of Sambucus nigra L. extract on inflammation, oxidative stress and tissue remodeling in a rat model of lipopolysaccharide-induced subacute rhinosinusitis.Apr 20, 2021

Click here to read the entire abstract

Pubmed Data : Inflammopharmacology. 2021 Apr 21. Epub 2021 Apr 21. PMID: 33881685

Article Published Date : Apr 20, 2021

Study Type : Animal Study

Additional Links

Substances : Elderberry

Diseases : Lipopolysaccharide-Induced Toxicity, Rhinosinusitis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

The water extract of savory may serve as a potential anti-inflammation agent in the treatment of rhinosinusitis disease.Oct 01, 2003

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2003 Oct;88(2-3):225- PMID: 12963147

Article Published Date : Oct 01, 2003

Study Type : Animal Study

Additional Links

Substances : Savory

Diseases : Rhinosinusitis, Sinusitis

[+]

Korean red ginseng and ginsenoside Rg3 suppress asian sand dust-induced epithelial-mesenchymal transition in nasal epithelial cells.Apr 19, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2022 Apr 20 ;27(9). Epub 2022 Apr 20. PMID: 35565992

Article Published Date : Apr 19, 2022

Study Type : In Vitro Study

Additional Links

Substances : Ginseng (Korean)

Diseases : Inflammation, Rhinosinusitis

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Nasal irrigation is effective in improving symptoms and the health status of patients with sinonasal disease.Jul 01, 2000

Click here to read the entire abstract

Pubmed Data : Laryngoscope. 2000 Jul;110(7):1189-93. PMID: 10892694

Article Published Date : Jul 01, 2000

Study Type : Review

Additional Links

Diseases : Allergic Rhinitis, Rhinosinusitis

Therapeutic Actions : Nasal Irrigation

[+]

Optimal management of allergic fungal rhinosinusitis.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Asthma Allergy. 2020 ;13:323-332. Epub 2020 Sep 11. PMID: 32982320

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Hydrogen Peroxide, Manuka Honey

Diseases : Rhinosinusitis

Therapeutic Actions : Photodynamic therapy

Pharmacological Actions : Anti-Bacterial Agents

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View the Evidence: 33 Abstracts with Rhinosinusitis Research

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Association between serum vitamin D and chronic rhinosinusitis: a meta-analysis.Oct 02, 2019

Nasal saline irrigations for the symptoms of chronic rhinosinusitis are well tolerated and beneficial.Jan 01, 2007

P. sidoides might offer symptom relief in acute bronchitis, rhinosinusitis and the common cold.Oct 21, 2013

A homeopathic remedy appears effective and tolerable treatment of acute rhinosinusitis.Apr 01, 2007

Antibiotics have only modest efficacy (1 in 8) in treating persistent nasal discharge (rhinosinusitis) in children.Jan 01, 2008

Chamomile extract is effective in further reducing the clinical symptoms and improving the quality of life of chronic rhinosinusitis patients.Sep 27, 2020

Effects of Nigella sativa extract on chronic rhinosinusitis.Nov 30, 2021

Integrating regular Bhramari pranayama along with the conventional treatment of chronic rhinosinusitis is more effective than conventional treatment alone.Apr 30, 2019

L-ascorbate may offer potential as a therapeutic agent for the improvement of chronic rhinosinusitis in patients with cystic fibrosis. May 01, 2009

Manuka honey may be effective for acute exacerbations of chronic rhinosinusitis.Dec 08, 2016

Manuka honey versus saline sinus irrigation in the treatment of cystic fibrosis-associated chronic rhinosinusitis.Aug 26, 2020

Nattokinase effectively shrinks the nasal polyp tissue through fibrin degradation.Sep 30, 2017

Pelargonium sidoides (umka) is well-tolerated and effective in the treatment of acute rhinosinusitis of presumably bacterial origin. Feb 01, 1985

Reflexology for acute rhinosinusitis.Dec 31, 2022

Saline nasal irrigation is efficacious for chronic sinonasal symptoms.Jul 01, 2005

The role of oral vitamin D3 supplementation in the treatment of Chronic Rhinosinusitis in adults with Vitamin D deficiency.May 31, 2020

The use of N. sativa nasal spray has symptom reliever effect with no adverse effects in patients.Dec 31, 2017

These results demonstrated better clinical and antimicrobial efficacy of EPs 7630 than amoxicillin.Sep 30, 2020

These results suggest an important mechanism of susceptibility to rhinitis and rhinosinusitis in highly PM2.5-polluted areas.Dec 31, 2019

Vitamin D has a protective effect against developing sinusitis.Aug 31, 2017

Xylitol nasal irrigation is effective and superior to saline irrigation in the management of chronic rhinosinusitisNov 01, 2011

5-Aminolevulinic acid mediated PDT on multi-antibiotic-resistant S. aureus and S. epidermidis from CRS patients was effective in vitro.Mar 06, 2016

These results suggests the possible use of apigenin as a chronic rhinosinusitis therapeutic agent which can suppress tissue remodelling in nasal mucosa.Dec 31, 2017

Baicalin ameliorates inflammatory response in a mouse model of rhinosinusitis.Jan 27, 2021

Intranasal application of NAC can decrease the inflammatory findings in murine acute rhinosinusitis.Jun 02, 2022

Lacticaseibacillus casei AMBR2 restores airway epithelial integrity in chronic rhinosinusitis.Jun 30, 2021

N. sativa could be used in the treatment of rhinosinusitis diseases.Jan 31, 2017

Sheep treated with silver showed a significant decrease in biofilm biomass.Mar 31, 2015

The impact of Sambucus nigra L. extract on inflammation, oxidative stress and tissue remodeling in a rat model of lipopolysaccharide-induced subacute rhinosinusitis.Apr 20, 2021

The water extract of savory may serve as a potential anti-inflammation agent in the treatment of rhinosinusitis disease.Oct 01, 2003

Korean red ginseng and ginsenoside Rg3 suppress asian sand dust-induced epithelial-mesenchymal transition in nasal epithelial cells.Apr 19, 2022

Nasal irrigation is effective in improving symptoms and the health status of patients with sinonasal disease.Jul 01, 2000

Optimal management of allergic fungal rhinosinusitis.Dec 31, 2019

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Rhinosinusitis

View the Evidence:
33 Abstracts with Rhinosinusitis Research