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16 Substances Researched for Sciatica
NameACCKFocus
Alpha-Lipoic Acid110Locked
Carnitine, Acetyl-L-110Locked
Citrus naringin23Locked
Aloe Vera12Locked
Basil12Locked
Chinese Herbal Formula: Qichu Fujin Recipe12Locked
Curcumin12Locked
EGCG (Epigallocatechin gallate)12Locked
Fermented Foods and Beverages12Locked
Genistein12Locked
Ginsenosides12Locked
Holy Basil12Locked
Natto 12Locked
Quercetin12Locked
Ursolic Acid12Locked
Naringenin 11Locked
4 Therapeutic Actions Researched for Sciatica
NameACCKFocus
Acupuncture230Locked
Chiropractic treatment220Locked
Massage/Therapeutic Touch110Locked
Laser Treatment: Low-Level12Locked
1 Problematic Actions Researched for Sciatica
NameACCKFocus
Surgical Procedures110Locked

View the Evidence:
26 Abstracts with Sciatica Research

[+]

Acupuncture treatment was significantly effective and safe compared to analgesics in sciatica.Aug 15, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Complement Ther Med. 2022 Aug 16:102872. Epub 2022 Aug 16. PMID: 35985442
Article Published Date : Aug 15, 2022
Study Type : Meta Analysis, Review
Additional Links
Diseases : Sciatica
Therapeutic Actions : Acupuncture
Pharmacological Actions : Antinoceceptive
[+]

Acupuncture may be effective in treating the pain associated with sciatica.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:192808. Epub 2015 Sep 6. PMID: 26425130
Article Published Date : Dec 31, 2014
Study Type : Meta Analysis, Review
Additional Links
Diseases : Sciatica
Therapeutic Actions : Acupuncture
Pharmacological Actions : Antinoceceptive
[+]

Chiropractic manipulation has a therapeutic effect on pain relief for acute back pain and sciatica with disc protrusion. Mar 01, 2006

Pubmed Data : Spine J. 2006 Mar-Apr;6(2):131-7. Epub 2006 Feb 3. PMID: 16517383
Article Published Date : Mar 01, 2006
Study Type : Human Study
Additional Links
Diseases : Herniated Disc, Low Back Pain, Sciatica
Therapeutic Actions : Chiropractic treatment
[+]

Massage therapy may have a therapeutic role in alleviating symptoms of sciatica and low back pain. Jul 01, 2008

Pubmed Data : J Bodyw Mov Ther. 2008 Jul;12(3):281-9. Epub 2008 Apr 10. PMID: 19083683
Article Published Date : Jul 01, 2008
Study Type : Human Study
Additional Links
Diseases : Low Back Pain, Sciatica
Therapeutic Actions : Massage/Therapeutic Touch
[+]

Sixty percent of patients with sciatica who had failed other medical management benefited from spinal manipulation to the same degree as if they underwent surgical intervention.Oct 01, 2010

Pubmed Data : J Manipulative Physiol Ther. 2010 Oct ;33(8):576-84. PMID: 21036279
Article Published Date : Oct 01, 2010
Study Type : Human Study
Additional Links
Diseases : Disc Herniation, Low Back Pain, Sciatica
Therapeutic Actions : Chiropractic treatment
Anti Therapeutic Actions : Surgical Procedures
[+]

Thiocitic (syn. Lipoic acid) and Acetyl-L-carnitine reduce sciatic pain caused by a herniated disc. Jan 01, 2008

Pubmed Data : Clin Drug Investig. 2008;28(8):495-500. PMID: 18598095
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Substances : Alpha-Lipoic Acid, Carnitine, Acetyl-L-
Diseases : Herniated Disc, Sciatic Neuralgia, Sciatica, Slipped Disk
[+]

Warming acupuncture effectively relieves symptoms of sciatica. Mar 01, 2009

Pubmed Data : J Tradit Chin Med. 2009 Mar;29(1):50-3. PMID: 19514189
Article Published Date : Mar 01, 2009
Study Type : Human Study
Additional Links
Diseases : Sciatica
Therapeutic Actions : Acupuncture
[+]

Aloe vera is an effective neuroprotective against sciatic nerve ischemia/reperfusion injury and was found to be as effective as methylprednisolone.Mar 31, 2016

Pubmed Data : Biomed Pharmacother. 2016 Apr ;79:201-7. Epub 2016 Mar 10. PMID: 27044829
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Aloe Vera
Diseases : Ischemia, Sciatica
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
Additional Keywords : Natural Substances Versus Drugs
[+]

Antinociceptive effect of isoorientin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve.Sep 30, 2019

Pubmed Data : Int Immunopharmacol. 2019 Oct ;75:105753. Epub 2019 Jul 20. PMID: 31336334
Article Published Date : Sep 30, 2019
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Sciatica
Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive , Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Basil essential oil inhibited the excitability of peripheral nervous system.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2016 ;2016:9012605. Epub 2016 Jun 30. PMID: 27446227
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Basil
Diseases : Sciatica
Additional Keywords : Essential Oils
[+]

Combing sinomenine and gabapentin or ligustrazine hydrochloride could be highly beneficial in neuropathic pain therapies.Jul 04, 2019

Pubmed Data : Eur J Pharmacol. 2019 Jul 5 ;854:101-108. Epub 2019 Apr 4. PMID: 30954565
Article Published Date : Jul 04, 2019
Study Type : Animal Study
Additional Links
Substances : Sinomenine
Diseases : Neuropathic Pain, Sciatica, Spinal Cord Injuries
Pharmacological Actions : Analgesics
Additional Keywords : Natural Substance/Drug Synergy
[+]

Comparison of the effects of electroacupuncture and melatonin on nerve regeneration in experimentally nerve-damage.Oct 30, 2021

Pubmed Data : J Acupunct Meridian Stud. 2021 Oct 31 ;14(5):176-182. PMID: 35770586
Article Published Date : Oct 30, 2021
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Sciatica
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Neuroprotective Agents, Regenerative
Additional Keywords : Nerve Regeneration
[+]

Curcumin and biodegradable membrane promote nerve regeneration and functional recovery after sciatic nerve transection.Dec 31, 2017

Pubmed Data : Ann Plast Surg. 2018 09 ;81(3):335-339. PMID: 30028754
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Peripheral Nerve Diseases, Sciatica
Pharmacological Actions : Neuroprotective Agents, Regenerative
Additional Keywords : Nerve Regeneration
[+]

Daily consumption of EGCG might be effective in the prevention and treatment of secondary damage related to peripheral nerve injury.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Turk Neurosurg. 2015 ;25(3):453-60. PMID: 26037187
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Lipid Peroxidation, Peripheral Nerve Diseases, Sciatica
Pharmacological Actions : Antioxidants
[+]

Genistein relieves neuropathic pain following chronic sciatic nerve injury in mice. Oct 01, 2008

Pubmed Data : J Neurochem. 2008 Oct;107(1):230-40. Epub 2008 Aug 8. PMID: 18691380
Article Published Date : Oct 01, 2008
Study Type : Animal Study
Additional Links
Substances : Genistein
Diseases : Diabetic Neuropathies, Sciatica
[+]

Ginsenoside Rg1 could effectively promote the regenerative repair of peripheral nerve injuryOct 31, 2014

Pubmed Data : Pak J Pharm Sci. 2014 Nov ;27(6 Suppl):2035-40. PMID: 25410069
Article Published Date : Oct 31, 2014
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Sciatica
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
Additional Keywords : Nerve Regeneration
[+]

Holy basil (O. sanctum) ameliorates sciatic nerve transection-induced neuropathy in rats. Oct 30, 2008

Pubmed Data : J Ethnopharmacol. 2008 Oct 30;120(1):56-62. Epub 2008 Aug 9. PMID: 18762236
Article Published Date : Oct 30, 2008
Study Type : Animal Study
Additional Links
Substances : Holy Basil
Diseases : Neuropathic Pain, Sciatica
[+]

Piperine treating sciatica through regulating inflammation and MiR-520a/P65 pathway.May 31, 2021

Pubmed Data : Chin J Nat Med. 2021 Jun ;19(6):412-421. PMID: 34092292
Article Published Date : May 31, 2021
Study Type : Animal Study
Additional Links
Substances : Piperine
Diseases : Inflammation, Sciatica
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-1 beta downregulation, MicroRNA modulator, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Quercetin was significantly superior to Gabapentine and morphine in terms of alleviating mechanical and thermal hypersensitivity.Mar 08, 2016

Pubmed Data : Acta Neurochir (Wien). 2016 Mar 9. Epub 2016 Mar 9. PMID: 26960544
Article Published Date : Mar 08, 2016
Study Type : Animal Study
Additional Links
Substances : Quercetin
Diseases : Neuropathic Pain, Sciatica
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Sciatic nerve regeneration by using collagen type I hydrogel containing naringin.Sep 10, 2019

Pubmed Data : J Mater Sci Mater Med. 2019 Sep 11 ;30(9):107. Epub 2019 Sep 11. PMID: 31512084
Article Published Date : Sep 10, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Peripheral Nerve Diseases, Sciatica
Additional Keywords : Nerve Regeneration
[+]

The Chinese herbal formula: Qichu Fujin Recipe stimulates regeneration and repair of injured sciatic nerve in rats. Sep 01, 2009

Pubmed Data : Zhong Xi Yi Jie He Xue Bao. 2009 Sep;7(9):848-54. PMID: 19747441
Article Published Date : Sep 01, 2009
Study Type : Animal Study
Additional Links
Substances : Chinese Herbal Formula: Qichu Fujin Recipe
Diseases : Demyelinating Diseases, Nerve Injuries, Sciatica
[+]

The fermented soy product natto improves neurobehavioral deficits after sciatic nerve injury in rats. May 01, 2007

Pubmed Data : Phytother Res. 2007 May;21(5):401-5. PMID: 19309538
Article Published Date : May 01, 2007
Study Type : Animal Study
Additional Links
Substances : Fermented Foods and Beverages, Natto
Diseases : Peripheral Nerve Diseases, Sciatica
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Therapeutic effect of paeoniflorin on chronic constriction injury of the sciatic nerve via the inhibition of Schwann cell apoptosis.May 01, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Phytother Res. 2022 May 2. Epub 2022 May 2. PMID: 35499270
Article Published Date : May 01, 2022
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Sciatica
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Nerve Regeneration
[+]

Ursolic acid induced neural regeneration after sciatic nerve injury in mice. Sep 24, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Regen Res. 2013 Sep 25 ;8(27):2510-9. PMID: 25206561
Article Published Date : Sep 24, 2013
Study Type : Animal Study
Additional Links
Substances : Ursolic Acid
Diseases : Sciatic Nerve Crush Injury, Sciatica
Pharmacological Actions : Enzyme Activators, MicroRNA modulator
Additional Keywords : Traditional Chinese Medicine
[+]

Use of low-power He-Ne laser therapy to accelerate regeneration processes of injured sciatic nerve in rabbit.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Egypt J Neurol Psychiatr Neurosurg. 2019 ;55(1):1. Epub 2019 Jan 5. PMID: 30679899
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Diseases : Sciatica
Therapeutic Actions : Laser Treatment: Low-Level
Additional Keywords : Nerve Regeneration
[+]

Naringin and naringenin could serve as anti-inflammatory agents in the treatment of low back pain and sciatica.Oct 03, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Spine J. 2019 Oct 4. Epub 2019 Oct 4. PMID: 31575107
Article Published Date : Oct 03, 2019
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin, Naringenin
Diseases : Low Back Pain, Sciatica
Pharmacological Actions : Anti-Inflammatory Agents, Regenerative
Additional Keywords : Nerve Regeneration

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