Septic Shock

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15 Substances Researched for Septic Shock
NameACCKFocus
Vitamin C1064Locked
Thiamine (B-1) 431Locked
Melatonin211Locked
NAC (N-acetyl-L-cysteine)211Locked
Folic Acid 110Locked
Vitamin B-12110Locked
Riboflavin (Vitamin B-2)24Locked
Cardamonin12Locked
Gastrodin12Locked
Genistein12Locked
Paeoniflorin12Locked
Resveratrol12Locked
Salvia miltiorrhiza12Locked
Colostrum11Locked
Blackberry10Locked

View the Evidence:
26 Abstracts with Septic Shock Research

[+]

A pilot study on the melatonin treatment in patients with early septic shock.Jul 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ir J Med Sci. 2022 Aug ;191(4):1913-1924. Epub 2021 Sep 1. PMID: 34468959
Article Published Date : Jul 31, 2022
Study Type : Human Study
Additional Links
Substances : Melatonin
Diseases : Septic Shock
[+]

Effect of high-dose intravenous ascorbic acid on microcirculation and endothelial glycocalyx during sepsis and septic shock.Sep 11, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Anesthesiol. 2023 Sep 12 ;23(1):309. Epub 2023 Sep 12. PMID: 37700249
Article Published Date : Sep 11, 2023
Study Type : Human Study
Additional Links
Substances : Vitamin C
Diseases : Septic Shock
[+]

Effects of hydrocortisone combined with vitamin C and vitamin B1 versus hydrocortisone alone on microcirculation in septic shock.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Hemorheol Microcirc. 2023 ;84(2):111-123. PMID: 36911931
Article Published Date : Dec 31, 2022
Study Type : Human Study
Additional Links
Substances : Thiamine (B-1) , Vitamin C
Diseases : Septic Shock
Additional Keywords : Natural Substances Versus Drugs
[+]

Folic acid and vitamin B12 as biomarkers of morbidity and mortality in patients with septic shock.Feb 13, 2022

Pubmed Data : Nutr Hosp. 2022 Feb 14. Epub 2022 Feb 14. PMID: 35156379
Article Published Date : Feb 13, 2022
Study Type : Human Study
Additional Links
Substances : Folic Acid , Vitamin B-12
Diseases : Septic Shock
[+]

High-dose ascorbic acid may be considered as an effective and safe adjuvant therapy in surgical critically ill patients with septic shock.Mar 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Res Pharm Pract. 2016 Apr-Jun;5(2):94-100. PMID: 27162802
Article Published Date : Mar 31, 2016
Study Type : Human Study
Additional Links
Substances : Vitamin C
Diseases : Sepsis, Septic Shock
Additional Keywords : Mortality, Risk Reduction
[+]

High-dose vitamin C improves norepinephrine level in patients with septic shock.Apr 11, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicine (Baltimore). 2024 Apr 12 ;103(15):e37838. PMID: 38608046
Article Published Date : Apr 11, 2024
Study Type : Human Study
Additional Links
Substances : Vitamin C
Diseases : Septic Shock
[+]

Hydrocortisone, vitamin C and thiamine for the treatment of sepsis and septic shock following cardiac surgery.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Indian J Anaesth. 2018 Dec ;62(12):934-939. PMID: 30636793
Article Published Date : Nov 30, 2018
Study Type : Human Study
Additional Links
Substances : Thiamine (B-1) , Vitamin C
Diseases : Cardiac Surgery, Sepsis, Septic Shock
[+]

NAC plus antibiotics might reduce the 30-day mortality rate in ICU patients with CR-Kp and CR-Ab septic shock.Mar 07, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antibiotics (Basel). 2021 Mar 8 ;10(3). Epub 2021 Mar 8. PMID: 33800296
Article Published Date : Mar 07, 2021
Study Type : Human Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Klebsiella Infections, Sepsis, Septic Shock
Additional Keywords : Risk Reduction
[+]

Thiamine administration has beneficial effects on lactate clearance and mortality in patients with septic shock.Jul 17, 2018

Pubmed Data : Crit Care Med. 2018 Jul 18. Epub 2018 Jul 18. PMID: 30028362
Article Published Date : Jul 17, 2018
Study Type : Human Study
Additional Links
Substances : Thiamine (B-1)
Diseases : Septic Shock
Additional Keywords : Mortality, Risk Reduction
[+]

Vitamin C improves microvascular reactivity and peripheral tissue perfusion in septic shock patients.Jan 20, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Crit Care. 2022 01 21 ;26(1):25. Epub 2022 Jan 21. PMID: 35062987
Article Published Date : Jan 20, 2022
Study Type : Human Study
Additional Links
Substances : Vitamin C
Diseases : Septic Shock
[+]

Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome.Jun 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Pharm Sin B. 2019 Jul ;9(4):734-744. Epub 2019 Feb 14. PMID: 31384534
Article Published Date : Jun 30, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Cardamonin
Diseases : Lipopolysaccharide-Induced Toxicity, Septic Shock
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Dihydrotanshinone I specifically inhibits NLRP3 inflammasome activation and protects against septic shock.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:750815. Epub 2021 Oct 14. PMID: 34721038
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Salvia miltiorrhiza
Diseases : Inflammation, Septic Shock
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Gastrodin alleviates inflammatory injury of cardiomyocytes in septic shock.Apr 30, 2021

Pubmed Data : In Vitro Cell Dev Biol Anim. 2021 May ;57(5):571-581. Epub 2021 Jun 9. PMID: 34106415
Article Published Date : Apr 30, 2021
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Septic Shock
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation
[+]

Genistein protects against septic shock in a rat model. Oct 01, 2010

Pubmed Data : J Nutr Biochem. 2010 Oct;21(10):935-40. Epub 2009 Sep 29. PMID: 12960677
Article Published Date : Oct 01, 2010
Study Type : Animal Study
Additional Links
Substances : Genistein
Diseases : Endotoxemia, Septic Shock, Shock: Septic
Additional Keywords : Lipopolysaccharide-Induced Damage
[+]

Paeoniflorin effectively improved cardiac function during endotoxemia.Apr 30, 2016

Pubmed Data : Biomed Pharmacother. 2016 May ;80:200-206. Epub 2016 Mar 28. PMID: 27133057
Article Published Date : Apr 30, 2016
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Endotoxemia, Lipopolysaccharide-Induced Toxicity, Sepsis, Septic Shock
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-12 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Resveratrol was beneficial for vasodilatation function in rats with septic shockAug 04, 2019

Pubmed Data : J Trauma Acute Care Surg. 2019 Aug 5. Epub 2019 Aug 5. PMID: 31389921
Article Published Date : Aug 04, 2019
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Septic Shock
Pharmacological Actions : Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Vasodilator Agents
[+]

Riboflavin represents a promising strategy for the treatment of sepsis and septic shock. May 25, 2004

Pubmed Data : Eur J Pharmacol. 2004 May 25;492(2-3):273-80. PMID: 15178375
Article Published Date : May 25, 2004
Study Type : Animal Study
Additional Links
Substances : Riboflavin (Vitamin B-2)
Diseases : Lipopolysaccharide-Induced Toxicity, Sepsis, Septic Shock
[+]

Riboflavin shows therapeutic effects in sepsis and septic shock. Mar 01, 2004

Pubmed Data : Infect Immun. 2004 Mar;72(3):1820-3. PMID: 14977995
Article Published Date : Mar 01, 2004
Study Type : Animal Study
Additional Links
Substances : Riboflavin (Vitamin B-2)
Diseases : Sepsis, Septic Shock
[+]

Ascorbate could act as an adjuvant therapy for severe sepsis and septic shock.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Crit Care. 2015 ;19(1):418. Epub 2015 Nov 27. PMID: 26612352
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : Vitamin C
Diseases : Sepsis, Septic Shock, Vitamin C Deficiency
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Ascorbic acid and N-acetylcysteine improve in vitro the function of lymphocytes from mice with endotoxin-induced oxidative stress.Jun 30, 2001

Pubmed Data : Free Radic Res. 2001 Jul ;35(1):73-84. PMID: 11697119
Article Published Date : Jun 30, 2001
Study Type : In Vitro Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine), Vitamin C
Diseases : Lipopolysaccharide-Induced Toxicity, Oxidative Stress, Septic Shock
Pharmacological Actions : Antioxidants, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Bovine colostrum protects against lipopolysaccharides secreted by Gram-negative bacterial pathogens. May 01, 2008

Pubmed Data : Int J Clin Pharmacol Ther. 2008 May;46(5):211-25. PMID: 18538107
Article Published Date : May 01, 2008
Study Type : Review
Additional Links
Substances : Colostrum
Diseases : Bacterial Infections and Mycoses, Endotoxemia, Septic Shock
[+]

Emerging evidence provides data in support of the administration of vitamin C in addition to standard therapy to ameliorate sepsis and septic shock.Sep 17, 2017

Pubmed Data : J Crit Care. 2017 Sep 18 ;43:230-234. Epub 2017 Sep 18. PMID: 28934705
Article Published Date : Sep 17, 2017
Study Type : Review
Additional Links
Substances : Vitamin C
Diseases : Sepsis, Septic Shock
[+]

Melatonin could be a useful treatment aid in ebola infections. Mar 31, 2015

Pubmed Data : J Med Virol. 2015 Apr ;87(4):537-43. Epub 2015 Jan 21. PMID: 25611054
Article Published Date : Mar 31, 2015
Study Type : Review
Additional Links
Substances : Melatonin
Diseases : Ebola Virus Infections, Inflammation, Septic Shock
Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents, Heme oxygenase-1 up-regulation
Additional Keywords : Cytokines
[+]

Parenteral administration of high-dose vitamin C and thiamine may be a beneficial adjuvant therapy of severe sepsis and septic shock.Aug 31, 2018

Pubmed Data : Crit Care Nurs Clin North Am. 2018 Sep ;30(3):343-351. Epub 2018 Jun 28. PMID: 30098738
Article Published Date : Aug 31, 2018
Study Type : Review
Additional Links
Substances : Vitamin C
Diseases : Sepsis, Septic Shock
[+]

Thiamine (vitamin B1) in septic shock: a targeted therapy.Jan 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Thorac Dis. 2020 Feb ;12(Suppl 1):S78-S83. PMID: 32148929
Article Published Date : Jan 31, 2020
Study Type : Review
Additional Links
Substances : Thiamine (B-1)
Diseases : Septic Shock
Additional Keywords : Risk Reduction
[+]

Blackberry extract exerts multiple protective effects in endotoxic shock.Aug 01, 2004

Pubmed Data : Planta Med. 2004 Aug;70(8):745-52. PMID: 15368665
Article Published Date : Aug 01, 2004
Additional Links
Substances : Blackberry
Diseases : Endotoxemia, Septic Shock

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