Sjogren's Syndrome

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17 Substances Researched for Sjogren's Syndrome
NameACCKFocus
Peony525Locked
Essential Fatty Acids211Locked
Cardamonin110Locked
Colostrum110Locked
DHA (Docosahexaenoic Acid)110Locked
DHEA (Dehydroepiandrosterone)110Locked
Pycnogenol (Pine Bark)110Locked
EGCG (Epigallocatechin gallate)57Locked
Paeoniflorin27Locked
Curcumin23Locked
Blueberry12Locked
Goji12Locked
Green Tea12Locked
Lactobacillus Acidophilus12Locked
Turmeric12Locked
Verbascoside12Locked
Melatonin11Locked
7 Problem Substances Researched for Sjogren's Syndrome
NameACCKFocus
Wheat330Locked
Gliadin220Locked
Gluten110Locked
Vaccine Adjuvants23Locked
Aluminum12Locked
Bisphenol A 11Locked
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)11Locked
7 Therapeutic Actions Researched for Sjogren's Syndrome
NameACCKFocus
Photobiomodulation110Locked
Dietary Modification: Allergen Free Diet13Locked
Dietary Modification: Beef Free13Locked
Dietary Modification: Cow's Milk/Casein Free13Locked
Dietary Modification: Elimination Diet13Locked
Dietary Modification: Nightshade Free13Locked
Dietary Modification: Wheat/Gluten Free13Locked
2 Problematic Actions Researched for Sjogren's Syndrome
NameACCKFocus
Vaccination: All26Locked
Vaccination: Hepatitis B13Locked
Related Topics

Sjogren's Syndrome is a Sub of the following Topic

View the Evidence:
38 Abstracts with Sjogren's Syndrome Research

[+]

An adverse immune reaction to wheat proteins is more commonly apparent (anti-tTG) in Sjögren's syndrome. Dec 01, 2003

Pubmed Data : J Rheumatol. 2003 Dec ;30(12):2613-9. PMID: 14719202
Article Published Date : Dec 01, 2003
Study Type : Human Study
Additional Links
Diseases : Sjogren's Syndrome
Additional Keywords : Anti-tissue Transglutaminase Antibodies
Problem Substances : Gluten, Wheat
Adverse Pharmacological Actions : Immunoreactive
[+]

Bovine Colostrum has beneficial effects in Sjogren's syndrome and oral lichen planus.Mar 01, 2002

Pubmed Data : Clin Oral Investig. 2002 Mar;6(1):11-20. PMID: 11996158
Article Published Date : Mar 01, 2002
Study Type : Human Study
Additional Links
Substances : Colostrum
Diseases : Oral Lichen Planus, Sjogren's Syndrome
[+]

Cardamonin is a potential candidate for controlling inflammation during primary Sjögren's syndrome.Mar 31, 2018

Pubmed Data : Immunopharmacol Immunotoxicol. 2018 Apr ;40(2):126-133. Epub 2018 Jan 5. PMID: 29303022
Article Published Date : Mar 31, 2018
Study Type : Human Study
Additional Links
Substances : Cardamonin
Diseases : Inflammation, Sjogren's Syndrome
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Celiac disease prevalance is significantly higher in those diagnosed with Sjogren's syndrome.Sep 01, 2004

Pubmed Data : Rheumatol Int. 2004 Sep;24(5):278-82. Epub 2003 Sep 17. PMID: 13680146
Article Published Date : Sep 01, 2004
Study Type : Human Study
Additional Links
Diseases : Celiac Disease, Sjogren's Syndrome
Additional Keywords : Diseases that are Linked
Problem Substances : Gliadin, Wheat
[+]

Data support pro- and anti-inflammatory roles within EFA metabolismSep 30, 1998

Pubmed Data : Prostaglandins Leukot Essent Fatty Acids. 1998 Oct ;59(4):239-45. PMID: 9849649
Article Published Date : Sep 30, 1998
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid), Essential Fatty Acids
Diseases : Sjogren's Syndrome
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Cell Membranes, Essential Fatty Acids, Sjogrens Syndrome
[+]

DHEA restores concentrations of sex steroids in primary Sjogren's syndrome. Jun 01, 2009

Pubmed Data : J Clin Endocrinol Metab. 2009 Jun;94(6):2044-51. Epub 2009 Mar 24. PMID: 19318446
Article Published Date : Jun 01, 2009
Study Type : Human Study
Additional Links
Substances : DHEA (Dehydroepiandrosterone)
Diseases : Sjogren's Syndrome
[+]

Effect of laser acupuncture on salivary flow rate in patients with Sjögren's syndrome.Jul 31, 2015

Pubmed Data : Lasers Med Sci. 2015 Aug ;30(6):1805-9. Epub 2014 May 13. PMID: 24820476
Article Published Date : Jul 31, 2015
Study Type : Human Study
Additional Links
Diseases : Sjogren's Syndrome
Therapeutic Actions : Photobiomodulation
[+]

Gut dysbiosis is prevailing in Sjögren's syndrome and is related to dry eye severity.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2020 ;15(2):e0229029. Epub 2020 Feb 14. PMID: 32059038
Article Published Date : Dec 31, 2019
Study Type : Human Study
Additional Links
Diseases : Dry Eye Syndromes, Dysbiosis, Sjogren's Syndrome
Additional Keywords : Risk Factors
[+]

Peony extract is equivalent to that of hydroxychloroquine sulfate but with higher safety in the treatment of Sjogren syndrome. Jul 01, 2007

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Jul;27(7):596-8. PMID: 17717915
Article Published Date : Jul 01, 2007
Study Type : Human Study
Additional Links
Substances : Peony
Diseases : Sjogren's Syndrome
[+]

Pycnogenol supplementation in patients with Sjogren syndromein a remission phase may be effective to control inflammation and reduce symptoms.Sep 30, 2018

Pubmed Data : Minerva Cardioangiol. 2018 Oct ;66(5):543-546. PMID: 30328688
Article Published Date : Sep 30, 2018
Study Type : Human Study
Additional Links
Substances : Pycnogenol (Pine Bark)
Diseases : Sjogren's Syndrome
Pharmacological Actions : Anti-Inflammatory Agents
[+]

There is a close association between Sjögren's syndrome and celiac disease. Even among nonceliac patients with primary Sjögren's syndrome, an ongoing inflammation is often present in the small bowel mucosa.Apr 01, 1999

Pubmed Data : Am J Gastroenterol. 1999 Apr;94(4):1042-6. PMID: 10201480
Article Published Date : Apr 01, 1999
Study Type : Human Study
Additional Links
Diseases : Celiac Disease, Sjogren's Syndrome
Additional Keywords : Diseases that are Linked
Problem Substances : Gliadin, Wheat
[+]

Total glucosides of paeony appears to improve the glandular secreting function and decrease the level of inflammatory cytokines.Sep 30, 2016

Pubmed Data : Int Immunopharmacol. 2016 Oct ;39:314-319. Epub 2016 Aug 11. PMID: 27517517
Article Published Date : Sep 30, 2016
Study Type : Human Study
Additional Links
Substances : Peony
Diseases : Sjogren's Syndrome
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Plant Extracts
[+]

Paeoniflorin may provide a new therapeutic approach to regulate P2X7R-mediated pathologic responses of primary Sjögren's syndrome.Aug 31, 2015

Pubmed Data : Int Immunopharmacol. 2015 Sep ;28(1):115-20. Epub 2015 Jun 3. PMID: 26049028
Article Published Date : Aug 31, 2015
Study Type : Human In Vitro
Additional Links
Substances : Paeoniflorin
Diseases : Sjogren's Syndrome
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

A case report of Non-Hodgkin's lymphoma of the thyroid after many years of immunizations.Aug 01, 2008

Pubmed Data : Pol Merkur Lekarski. 2008 Aug ;25(146):155-7. PMID: 18942337
Article Published Date : Aug 01, 2008
Study Type : Human: Case Report
Additional Links
Diseases : Hashimoto's thyroiditis, Lymphoma, Sjogren's Syndrome, Thyroid Cancer, Vaccine-induced Toxicity
Anti Therapeutic Actions : Vaccination: All
[+]

A case report of Sjogren's syndrome after hepatitis B vaccination.Sep 01, 2000

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arthritis Rheum. 2000 Sep ;43(9):2139-40. PMID: 11014366
Article Published Date : Sep 01, 2000
Study Type : Human: Case Report
Additional Links
Diseases : Sjogren's Syndrome, Vaccine-induced Toxicity
Anti Therapeutic Actions : Vaccination: All, Vaccination: Hepatitis B
[+]

Reversal of premature ovarian failure in a patient with Sjögren syndrome using an elimination diet protocol has been reported. Jul 01, 2010

Pubmed Data : J Altern Complement Med. 2010 Jul;16(7):807-9. PMID: 20618099
Article Published Date : Jul 01, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Ovarian Diseases, Ovarian Failure, Sjogren's Syndrome
Therapeutic Actions : Dietary Modification: Allergen Free Diet, Dietary Modification: Beef Free, Dietary Modification: Cow's Milk/Casein Free, Dietary Modification: Elimination Diet, Dietary Modification: Nightshade Free, Dietary Modification: Wheat/Gluten Free
Additional Keywords : Disease Reversal
[+]

Acteoside promotes B cell-derived IL-10 production and ameliorates autoimmunity.Sep 30, 2022

Pubmed Data : J Leukoc Biol. 2022 Oct ;112(4):875-885. Epub 2022 May 31. PMID: 35638582
Article Published Date : Sep 30, 2022
Study Type : Animal Study
Additional Links
Substances : Verbascoside
Diseases : Autoimmune Diseases, Rheumatoid Arthritis, Sjogren's Syndrome
Pharmacological Actions : Interleukin-10 upregulation, Interleukin-17 downregulation
[+]

Alum induces a Sjögren’s syndrome-like disorder in mice.Feb 28, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Exp Rheumatol. 2014 Mar-Apr;32(2):251-5. Epub 2014 Apr 9. PMID: 24739520
Article Published Date : Feb 28, 2014
Study Type : Animal Study
Additional Links
Diseases : Sjogren's Syndrome, Vaccine-induced Toxicity
Problem Substances : Aluminum, Vaccine Adjuvants
[+]

Blueberry stem extract prevents lacrimal hyposecretion. Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : In Vivo. 2023 ;37(3):1003-1015. PMID: 37103112
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Blueberry
Diseases : Dry Eye Syndromes, Sjogren's Syndrome
Additional Keywords : Plant Extracts
[+]

Green tea polyphenols reduce autoimmune symptoms in a mouse model for human Sjogren's syndrome. Mar 01, 2007

Pubmed Data : Autoimmunity. 2007 Mar;40(2):138-47. PMID: 17364504
Article Published Date : Mar 01, 2007
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Green Tea
Diseases : Sjogren's Syndrome
[+]

Induction of p21 by EGCG could provide clinically useful normalization of salivary glands by promoting differentiation and reducing PCNA levels.Jan 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Inflamm Allergy Drug Targets. 2014 Feb ;13(1):15-24. PMID: 24329914
Article Published Date : Jan 31, 2014
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Autoimmune Diseases, Diabetes Mellitus: Type 1: Prevention, Sjogren's Syndrome
Pharmacological Actions : Anticarcinogenic Agents, P21 Activation, Tumor Suppressor Protein p53 Upregulation
[+]

Lactobacillus acidophilus and propionate attenuate Sjögren's syndrome.Jun 13, 2023

Pubmed Data : Cell Commun Signal. 2023 Jun 14 ;21(1):135. Epub 2023 Jun 14. PMID: 37316856
Article Published Date : Jun 13, 2023
Study Type : Animal Study
Additional Links
Substances : Lactobacillus Acidophilus
Diseases : Inflammation, Sjogren's Syndrome
Additional Keywords : Gene Expression Regulation
[+]

Lycium barbarum polysaccharide ameliorates Sjögren's syndrome.Dec 31, 2020

Pubmed Data : Mol Nutr Food Res. 2021 06 ;65(11):e2001118. Epub 2021 May 5. PMID: 33825332
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Goji
Diseases : Sjogren's Syndrome
Pharmacological Actions : Immunomodulatory
Additional Keywords : Polysaccharides
[+]

Oral consumption of the green tea polyphenol EGCG improves disease paramaters in a mouse model of human Sjogren's syndrome. Oct 24, 2008

Pubmed Data : Life Sci. 2008 Oct 24;83(17-18):581-8. Epub 2008 Sep 6. PMID: 18809413
Article Published Date : Oct 24, 2008
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Sjogren's Syndrome
[+]

Paeoniflorin ameliorates symptoms of experimental Sjogren's syndrome associated with down-regulating Cyr61 expression.Dec 31, 2015

Pubmed Data : Int Immunopharmacol. 2016 Jan ;30:27-35. Epub 2015 Nov 26. PMID: 26630293
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Sjogren's Syndrome
Pharmacological Actions : Anti-Inflammatory Agents
[+]

The effect of total glucoside of paeony on gut microbiota in NOD mice with Sjögren's syndrome.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Chin Med. 2020 ;15:61. Epub 2020 Jun 11. PMID: 32536964
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Peony
Diseases : Sjogren's Syndrome
Pharmacological Actions : Gastrointestinal Agents
[+]

These studies show that ultrasoluble curcumin and turmeric could prove useful as a therapeutic intervention in systemic lupus erythematosus and Sjogren's syndrome.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Lupus Sci Med. 2015 ;2(1):e000114. Epub 2015 Sep 8. PMID: 26380101
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Curcumin, Turmeric
Diseases : Lupus Erythematosus: Systemic, Lymphadenopathy, Oxidative Stress, Proteinuria, Sjogren's Syndrome
Pharmacological Actions : Antioxidants, Renoprotective
Additional Keywords : Plant Extracts
[+]

Total glucosides of peony ameliorates Sjögren's syndrome by affecting the Th1/Th2 cytokine balance.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2016 Mar ;11(3):1135-1141. Epub 2016 Jan 22. PMID: 26998049
Article Published Date : Feb 29, 2016
Study Type : Animal Study
Additional Links
Substances : Peony
Diseases : Sjogren's Syndrome
Pharmacological Actions : Immunomodulatory, Interferon Gamma Reducer, Interleukin-4 downregulation
[+]

A comprehensive review of the influence of Epigallocatechin gallate on Sjögren's syndrome associated molecular regulators of exocytosis.Oct 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Rep. 2021 Nov ;15(5):95. Epub 2021 Sep 21. PMID: 34631050
Article Published Date : Oct 31, 2021
Study Type : Review
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Sjogren's Syndrome
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents
[+]

BPA accelerated the progression and further deterioration of primary Sjögren's syndrome.Dec 25, 2019

Pubmed Data : Immunopharmacol Immunotoxicol. 2019 Dec 26:1-9. Epub 2019 Dec 26. PMID: 31876196
Article Published Date : Dec 25, 2019
Study Type : In Vitro Study
Additional Links
Diseases : Bisphenol Toxicity, Sjogren's Syndrome
Additional Keywords : Increased Risk
Problem Substances : Bisphenol A
[+]

Combined use of total glucosides of paeony and hydroxychloroquine in primary Sjögren's syndrome.Sep 30, 2023

Pubmed Data : Immun Inflamm Dis. 2023 Oct ;11(10):e1044. PMID: 37904705
Article Published Date : Sep 30, 2023
Study Type : Review
Additional Links
Diseases : Sjogren's Syndrome
Additional Keywords : Natural Substance/Drug Synergy
[+]

Essential fatty acid supplementation may be beneficial in treating Sjogren's syndrome.Jul 01, 1984

Pubmed Data : Med Hypotheses. 1984 Jul;14(3):233-47. PMID: 6088955
Article Published Date : Jul 01, 1984
Study Type : Commentary
Additional Links
Substances : Essential Fatty Acids
Diseases : Sjogren's Syndrome
[+]

Heat-solubilized curry spice curcumin inhibits antibody-antigen interaction in in vitro studies indicating it may help to alleviate autoimmune diseases.Aug 01, 2010

Pubmed Data : Mol Nutr Food Res. 2010 Aug;54(8):1202-9. PMID: 20146265
Article Published Date : Aug 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Autoimmune Diseases, Lupus Erythematosus: Systemic, Sjogren's Syndrome
Additional Keywords : Plant Extracts
[+]

Melatonin relieves Th17/CD4 - CD8 - T cells inflammatory responses via nuclear-receptor dependent manner in peripheral blood of primary Sjögren's syndrome.May 06, 2022

Pubmed Data : Int Immunopharmacol. 2022 May 7 ;109:108778. Epub 2022 May 7. PMID: 35537347
Article Published Date : May 06, 2022
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Sjogren's Syndrome
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation
[+]

Review of studies showing various EFAs as treatments for rheumatologic conditions.Dec 31, 1999

Pubmed Data : Am J Clin Nutr. 2000 Jan ;71(1 Suppl):352S-6S. PMID: 10617996
Article Published Date : Dec 31, 1999
Study Type : Review
Additional Links
Diseases : Rheumatoid Arthritis, Sjogren's Syndrome
Additional Keywords : Evening Primrose Oil; Rheumatoid Arthritis
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Targets of total glucosides of paeony in the treatment of Sjogren syndrome.Mar 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Chin Med Assoc. 2023 Apr 1 ;86(4):375-380. Epub 2023 Jan 19. PMID: 36653917
Article Published Date : Mar 31, 2023
Study Type : In Vitro Study
Additional Links
Substances : Peony
Diseases : Sjogren's Syndrome
Pharmacological Actions : Anti-Apoptotic, Antioxidants
[+]

The aim of this review was to focus on Sjogren's Syndrome and its possible development following vaccine or silicone exposure.May 31, 2014

Pubmed Data : J Autoimmun. 2014 Jun ;51:10-6. Epub 2014 Apr 26. PMID: 24774584
Article Published Date : May 31, 2014
Study Type : Review
Additional Links
Diseases : Autoimmune/inflammatory syndrome induced by adjuvants (ASIA), Inflammation, Sjogren's Syndrome, vaccine injury
Problem Substances : Vaccine Adjuvants
[+]

EGCG inhibits autoantigen expression in a way relevant to the treatment of Sjogen's syndrome.Nov 01, 2005

Pubmed Data : J Pharmacol Exp Ther. 2005 Nov;315(2):805-11. Epub 2005 Jul 26. PMID:16046615
Article Published Date : Nov 01, 2005
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Sjogren's Syndrome

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