Skin Cancer

Name	AC	CK
Coffee	9	160
Curcumin	58	86
Vitamin D	16	45
Caffeine	3	40
Chlorogenic Acid	1	40
Sulforaphane	13	29
Vitamin C	21	29
Ginsenosides	15	24
Solasodine glycoalkaloids	2	24
Resveratrol	18	23
Black Tea	1	20
Citrus Peel	1	20
Mistletoe	5	20
Flavonoids	9	15
Turmeric	4	15
Apigenin	6	14
Ashwagandha	8	14
Green Tea	10	14
Quercetin	10	14
Cannabinoids	7	13
EGCG (Epigallocatechin gallate)	10	13
Carrot	4	12
Antioxidants: Fat Soluble	1	10
Broccoli Sprouts	1	10
Euphorbia peplus	1	10
Indole-3-Carbinol	7	10
St. Johns Wort	1	10
Tocopherols	1	10
Berberine	8	9
Lichens	5	9
Naringenin	4	9
Olive leaf extract	3	9
Phloretin	4	9
Pterostilbene	6	9
Rosemary	4	9
Chaga Mushroom (Inonotus obliquus)	5	8
Fisetin	6	8
Polyphenols	7	8
Shikonin	5	8
Anthocyanins	5	7
Betulinic acid	4	7
Emodin	5	7
Fucoidan	6	7
Homeopathic Medicine: All	4	7
Licorice	5	7
Parthenolide	5	7
Phellinus Linteus	5	7
Tocotrienol: Delta	3	7
Tocotrienols	2	7
Carnosol	4	6
Catechin	4	6
Chrysin	4	6
Grape Seed Extract	2	6
Nexrutine (Phellodendrom)	2	6
Nicotinamide	3	6
Thymoquinone	5	6
Zerumbone	2	6
Beta-Elemene	4	5
Cinnamon	3	5
Ellagic Acid	3	5
Genistein	5	5
Honokiol	4	5
Isoliquiritigenin	4	5
Lithospermum erythrorhizon	2	5
Luteolin	3	5
Lycopene	3	5
Oleuropein	3	5
Pomegranate	3	5
Reishi Mushroom	3	5
Sage	4	5
Sandalwood	3	5
Silibinin	3	5
Tanshinone IIA	2	5
Aloe Vera	3	4
Apple	2	4
Bacopa	2	4
Bael	2	4
Bee Venom	4	4
Bromelain	3	4
Cannabinoids: Synthetic	2	4
Cannabis	3	4
Cinnamaldehyde	2	4
D-Limonene	2	4
Delphinidin	2	4
Delta-tetrahydrocannabinol (THC)	2	4
Essential Oils: Unspecified	3	4
Flaxseed	1	4
Gymnema Sylvestre	2	4
Honeybush	3	4
Milk Thistle	2	4
Moringa oleifera	4	4
Oleanolic acid	1	4
Prickly Pear Cactus	2	4
Protandim	2	4
Rooibos	3	4
Stilbenes	2	4
Ursolic Acid	3	4
Vitamin A	3	4
Wheat Grass	2	4
Antrodia camphorata	2	3
Astaxanthin	2	3
Bamboo	2	3
Bee Propolis	2	3
Cannabidiol	2	3
Cashew	2	3
Collagen	2	3
Crocin	2	3
Cucurbitacin B	2	3
Dandelion	2	3
Demethoxycurcumin	3	3
Diosmin	2	3
Eucalyptus	2	3
Fermented Foods and Beverages	2	3
Gallic Acid	2	3
Ginger	3	3
Ginkgo biloba	2	3
Grape	2	3
Hesperidin	2	3
Mangosteen	2	3
Phyllanthus amarus	2	3
Phyllanthus niruri (Stonebreaker)	2	3
Phyllanthus urinaria	2	3
Raspberry	2	3
Rutin	2	3
Sesamol	2	3
Spirulina	2	3
Turkey Tail Mushroom	2	3
Vitamin E: Gamma-tocotrienol	2	3
Whey	2	3
Xanthohumol	2	3
beta-Carotene	2	3
Acai	1	2
Achiote	1	2
Alpha-Carotene	1	2
Angelica	1	2
Baicalein	2	2
Benzyl isothiocyanate	2	2
Broccoli	1	2
Burdock	1	2
Carnosic Acid	2	2
Carotenoids	1	2
Celery	1	2
Clove	1	2
Cordyceps sinensis	1	2
Cruciferous Vegetables	2	2
Ferulic acid	1	2
Feverfew	2	2
Frankincense	1	2
Fucoxanthin	1	2
Garlic	2	2
Geraniol	2	2
Ginseng	1	2
Ginseng (American)	1	2
Goldenseal	1	2
Henna	1	2
Hibiscus sabdariffa	2	2
Holy Basil	1	2
Isothiocyanates	2	2
Kaempferol	1	2
Lactoferrin	2	2
Lemon Peel	1	2
Loquat Leaves	2	2
Lupeol	1	2
Magnolol	2	2
Melatonin	2	2
Myricetin	2	2
Nobiletin	1	2
Olive Oil	2	2
Orange: Mandarin	1	2
Paeonol	1	2
Papaya: Fermented	1	2
Phenethyl isothiocyanate	2	2
Piceatannol	2	2
Pycnogenol (Pine Bark)	1	2
Red Wine	1	2
Red Wine Extract	1	2
Rye	1	2
Saffron	2	2
Secale cornutum	1	2
Sesame Seed Oil	1	2
Shiitake Mushroom	1	2
Soursop	1	2
Soy Protein	1	2
Syrian rue	2	2
Tea Tree	2	2
Thyme	2	2
Tocotrienol: Alpha	1	2
Tocotrienol: Gamma	1	2
Triptolide	1	2
Viruses: Beneficial	1	2
Zeaxanthin	2	2
Zedoary	1	2
Adlay	1	1
African Basil	1	1
Allicin	1	1
Amygdalin	1	1
Andrographis	1	1
Asiatic Acid	1	1
Babchi	1	1
Bai Zhu	1	1
Banana Peel	1	1
Basil	1	1
Bay leaf	1	1
Beta Sitosterol	1	1
Biochanin A	1	1
Bloodroot	1	1
Blueberry	1	1
Caffeic Acid	1	1
Caffeic acid phenethyl ester	1	1
Catechols	1	1
Chokeberry	1	1
Citral	1	1
Curcuma Longa	1	1
Curcumol	1	1
Daidzein	1	1
Damnacanthal	1	1
Deuterium (heavy water)	1	1
Diosgenin	1	1
Diosmetin	1	1
Endocannabinoids	1	1
Evening Primrose Oil	1	1
Folic Acid	1	1
Geum japonicum	1	1
Ginseng (Korean)	1	1
Glycyrrhizin	1	1
Goji	1	1
Gotu Kola	1	1
Grapefruit	1	1
Graviola	1	1
Hazelnut	1	1
Hibiscus rosa-sinensis	1	1
Huaier (Trametes robiniophila murr)	1	1
Hydroxytyrosol	1	1
Inositol Hexaphosphate	1	1
Kefir	1	1
Kiwifruit	1	1
Lotus	1	1
Lutein	1	1
Marigold	1	1
Medicinal Mushrooms	1	1
Modified Citrus Pectin	1	1
Nettle	1	1
Nordihydroguaiaretic acid (NDGA)	1	1
Okra	1	1
Oleocanthal	1	1
Omega-3 Fatty Acids	1	1
Oridonin	1	1
P-Coumaric Acid	1	1
Passion Flower	1	1
Pea	1	1
Pear	1	1
Piperidines	1	1
Piperlongumine	1	1
Polygonatum cyrtonema	1	1
Potato	1	1
Psychedelics:All	1	1
Punicalagin	1	1
Rice Bran	1	1
Roseoside	1	1
S-Adenosylmethionine (SAMe)	1	1
Seaweed: Brown	1	1
Sophora Flavescens	1	1
Squash: Butternut	1	1
Sugar-apple	1	1
Tansy	1	1
Theaflavins	1	1
Vanillin	1	1
Venom: Snake	1	1
Verbascoside	1	1
Vitamin B-3 (Niacin)	1	1
Vitamin E	1	1
Vitamin K	1	1
Walnut	1	1
Wasabi	1	1
Water Mint	1	1
Wheat Germ	1	1
White Button Mushroom	1	1
Wormwood	1	1

Name	AC	CK
Eszopiclone	1	40
Hypnotic Drugs	1	40
Ramelteon	1	40
Zaleplon	1	40
Zolpidem (trade name Ambien)	1	40
Glyphosate	3	22
Pesticides	2	22
Statin Drugs	2	21
Arsenic	1	20
Mineral Oil	2	12
Dl-alpha-tocopherol acetate	1	10
Fingolimod	1	10
Meat	1	10
Prednisone	1	10
Tumor Necrosis Factor (TNF) Inhibitor Drugs	1	10
Cisplatin	1	6
Doxorubicin	1	6
Paclitaxel	1	6
Croton oil	2	3
Acetaminophen	1	2
Benzo(a)pyrene	1	2
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	2
Roundup (herbicide)	2	2
Tobacco	1	2
Glyphosate formulations	1	1
Nanoparticles	1	1
Nicotine	1	1
Parabens	1	1
Sodium lauryl sulfate	1	1
Sunscreen	1	1
Titanium Dioxide	1	1

Name	AC	CK
Dietary Modification: Mediterranean Diet	1	30
Sunlight exposure	8	19
Doing Nothing	1	10
Gerson Therapy	1	10
Light-Emitting Diodes (LEDs) Therapy	1	5
Light Therapy	3	4
Photodynamic therapy	3	4
Dietary Modification: Low Carbohydrate	1	2
Homeopathic Treatment	1	2
Cryotherapy	1	1
Heat Therapy	1	1
Laser Treatment: Low-Level	1	1
Sunlight Exposure: UVB Light	1	1

Name	AC	CK
Electromagnetic Field Harms	1	20
Electromagnetic Radiation	1	20
Vaccination: Smallpox	2	6
Vaccination: BCG (Tuberculosis)	1	3
Biopsy Procedure: Sentinel Lymph-Node	1	1
Biopsy: Various Tissue	1	1
Nanotechnology	1	1

[+]

Coffee intake appears to exert a moderate protective effect against basal cell cancer development.Jul 06, 2016

Click here to read the entire abstract

Pubmed Data : Eur J Nutr. 2016 Jul 7. Epub 2016 Jul 7. PMID: 27388462

Article Published Date : Jul 06, 2016

Study Type : Meta Analysis, Review

Additional Links

Substances : Caffeine, Coffee

Diseases : Basal Cell Carcinoma

Pharmacological Actions : Chemopreventive

[+]

Coffee intake was associated with reduced risk of oral, pharynx, liver, colon, prostate, endometrial cancer and melanoma, but increased lung cancer risk.Sep 25, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2016 Sep 26 ;6:33711. Epub 2016 Sep 26. PMID: 27665923

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2016 ;11(1):e0147056. Epub 2016 Jan 27. PMID: 26816289

Article Published Date : Dec 31, 2015

Study Type : Meta Analysis

Additional Links

Substances : Coffee

Diseases : Malignant Melanoma

Pharmacological Actions : Chemopreventive

Additional Keywords : Risk Reduction

[+]

This meta-analysis suggested that caffeinated coffee might have chemopreventive effects against basal cell carcinoma.Nov 28, 2016

Click here to read the entire abstract

Pubmed Data : Eur J Cancer Prev. 2016 Nov 29. Epub 2016 Nov 29. PMID: 27902644

Pubmed Data : BMC Dermatol. 2001;1:3. Epub 2001 Aug 1. PMID: 11527506

Article Published Date : Jan 01, 2001

Study Type : Human Study

Additional Links

Substances : Black Tea, Citrus Peel

Diseases : Skin Cancer, Skin Cancer: Squamous Cell

[+]

consumption of caffeinated coffee was inversely associated with melanoma risk among men.Feb 19, 2017

Click here to read the entire abstract

Pubmed Data : Int J Cancer. 2017 Feb 20. Epub 2017 Feb 20. PMID: 28218395

Article Published Date : Feb 19, 2017

Study Type : Human Study

Additional Links

Substances : Caffeine, Coffee

Diseases : Melanoma

Additional Keywords : Risk Reduction

[+]

Decreased vitamin D serum levels at melanoma diagnosis are associated with tumor ulceration and high tumor mitotic rate.Aug 27, 2019

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Pubmed Data : Melanoma Res. 2019 Aug 28. Epub 2019 Aug 28. PMID: 31469708

Click here to read the entire abstract

Pubmed Data : Int J Dermatol. 2008 Jan ;47(1):78-82. PMID: 18173610

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Cancer. 2016 Jul 29 ;16:562. Epub 2016 Jul 29. PMID: 27473841

Click here to read the entire abstract

Pubmed Data : J Dermatol. 2015 Aug 18. Epub 2015 Aug 18. PMID: 26283637

Click here to read the entire abstract

Pubmed Data : Cancer Immunol Immunother. 2016 Jan ;65(1):83-92. Epub 2015 Dec 8. PMID: 26646850

Article Published Date : Dec 31, 2015

Study Type : Human In Vitro, In Vitro Study

Additional Links

Substances : Phloretin

Diseases : Melanoma

Pharmacological Actions : Chemotherapeutic

[+]

[+]

Capsaicin exerts therapeutic effects by targeting tNOX-SIRT1 axis and augmenting ROS-dependent autophagy in melanoma cancer cells.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Cancer Res. 2021 ;11(9):4199-4219. Epub 2021 Sep 15. PMID: 34659883

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Otol Neurotol. 2021 Sep 30. Epub 2021 Sep 30. PMID: 34607999

Article Published Date : Sep 29, 2021

Study Type : Human: Case Report

Additional Links

Diseases : Melanoma

Additional Keywords : Spontaneous Tumor Regression

[+]

Squamous cell carcinoma in ulcer after bacille Calmette-Guérin vaccination.Oct 12, 2014

Pubmed Data : Medicine (Baltimore). 2017 Nov ;96(46):e8731. PMID: 29145317

Article Published Date : Oct 31, 2017

Study Type : Human: Case Report

Additional Links

Substances : Mistletoe

Diseases : Melanoma, Skin Cancer

Pharmacological Actions : Chemopreventive, Immunomodulatory

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Restoration of ascorbate from adequate to optimal physiological levels reduced tumor growth rates and moderated HIF-1 pathway activityJan 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Cancer Res. 2015 May 6. Epub 2015 May 6. PMID: 25948588

Article Published Date : May 05, 2015

Study Type : Animal Study

Additional Links

Substances : Cinnamon

Diseases : Leukemia, Skin Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemopreventive

[+]

A lipid-soluble ginseng extract potently inhibited invasion and migration of B16F10 mouse melanoma cells in a dose-dependent manner.Dec 31, 2014

Click here to read the entire abstract

Pubmed Data : J Med Food. 2015 Jan ;18(1):102-8. PMID: 25354136

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Clin Invest. 2003 Jan ;111(1):43-50. PMID: 12511587

Click here to read the entire abstract

Pubmed Data : Cancer Lett. 2005 Mar 18;220(1):21-8. PMID: 15737684

Article Published Date : Mar 18, 2005

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Skin Cancer

Pharmacological Actions : Apoptotic, Cell cycle arrest

Additional Keywords : Antiproliferative, Selective Cytotoxicity

[+]

An isocaloric carbohydrate restriction diet and natural AMPK activating agents induce synergistic anticancer effects.Mar 18, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Eur J Cancer Prev. 2015 Mar 19. Epub 2015 Mar 19. PMID: 25747515

Article Published Date : Mar 18, 2015

Study Type : In Vitro Study, Transgenic Animal Study

Pubmed Data : Anticancer Res. 2010 Jan;30(1):111-8. PMID: 20150624

Article Published Date : Jan 01, 2010

Study Type : Animal Study

Additional Links

Substances : Bamboo

Diseases : Melanoma

Pharmacological Actions : Anti-Tumor, Antioxidants, Immunomodulatory

[+]

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancers (Basel). 2020 Jan 29 ;12(2). Epub 2020 Jan 29. PMID: 32013122

Article Published Date : Jan 28, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cinnamaldehyde

Diseases : Melanoma

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Additional Keywords : Natural Substances Versus Drugs

[+]

Cordyceps has significant therapeutic action against melanoma cell growth in mice with no adverse side effects.Dec 01, 2004

Click here to read the entire abstract

Pubmed Data : Clin Exp Pharmacol Physiol. 2004 Dec;31 Suppl 2:S51-3 PMID: 15649290

Article Published Date : Dec 01, 2004

Study Type : Animal Study

Additional Links

Substances : Cordyceps sinensis

Diseases : Melanoma

[+]

Coupling to a cancer cell-specific antibody potentiates tumoricidal properties of curcumin.Aug 14, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Cancer. 2012 Aug 15 ;131(4):E569-78. Epub 2012 Jan 3. PMID: 21989768

Article Published Date : Aug 14, 2012

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Melanoma

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Crocin may exhibit significant melanoma tumor remission properties by positively modulating tumor growth related parameters.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Oncol Rep. 2015 Nov 12. Epub 2015 Nov 12. PMID: 26573768

Article Published Date : Nov 11, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Melanoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Autophagy Up-regulation, Cell cycle arrest

[+]

Curcumin exerts its in vitro anti-angiogenic and in vivo anti-tumour properties through combined PDE2 and PDE4 inhibition.Jan 31, 2015

Click here to read the entire abstract

Pubmed Data : Thromb Haemost. 2015 Feb ;113(2):319-28. Epub 2014 Sep 18. PMID: 25230992

Pubmed Data : J Exp Clin Cancer Res. 2003 Sep;22(3):419-24. PMID: 14582701

Article Published Date : Sep 01, 2003

Study Type : Animal Study

Additional Links

Substances : D-Limonene

Diseases : Malignant Melanoma, Melanoma: Metastatic

[+]

D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.Jul 31, 2012

Click here to read the entire abstract

Pubmed Data : Hum Exp Toxicol. 2012 Aug ;31(8):798-811. Epub 2012 Feb 8. PMID: 22318307

Article Published Date : Jul 31, 2012

Study Type : Animal Study

Additional Links

Substances : D-Limonene

Diseases : Inflammation, Oxidative Stress, Skin Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive

[+]

Dandelion prevents chemical carcinogenesis.Jan 01, 2008

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Pubmed Data : J Exp Ther Oncol. 2008;7(4):275-84. PMID: 10408234

Exposure to cancer exosomes altered the gene expression in the normal cells of mice. Dec 31, 2008

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2009 ;4(4):e5219. Epub 2009 Apr 17. PMID: 19381331

Article Published Date : Dec 31, 2008

Study Type : Animal Study

Additional Links

Diseases : Melanoma

Additional Keywords : Disease Progression, Exosomes, Tumor Associated Antigens

[+]

Henna positively modulates phase I and II enzymes in a mouse model of skin adn forestomach cancer. Mar 01, 2003

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Pubmed Data : Mol Cell Biochem. 2003 Mar;245(1-2):11-22. PMID: 12708740

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Carcinog. 2016 Jan ;55(1):3-14. Epub 2014 Dec 9. PMID: 25492239

Pubmed Data : Photochem Photobiol. 2010 Nov-Dec;86(6):1318-26. Epub 2010 Oct 14. PMID: 20946358

Article Published Date : Nov 01, 2010

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : Antioxid Redox Signal. 2015 Dec 9. Epub 2015 Dec 9. PMID: 26651028

Article Published Date : Dec 08, 2015

Study Type : Animal Study

Additional Links

Substances : Pterostilbene

Diseases : Melanoma, Pancreatic Cancer

Pharmacological Actions : Antiproliferative

[+]

Punica granatum pericarp extract suppressed tumor proliferation and angiogenesis in a model of melanoma.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Cancer Prev Res (Phila). 2010 Feb;3(2):170-8. Epub 2010 Jan 26. PMID: 20103723

Article Published Date : Feb 01, 2010

Study Type : Animal Study

Additional Links

Substances : Ellagic Acid, Resveratrol, Stilbenes

Diseases : Skin Cancer

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Chemopreventive

Additional Keywords : Drug Synergy

[+]

Additional Keywords : Plant Extracts

[+]

Shikonin suppressed chemically induced skin carcinogenesis in this animal study. Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2015 ;10(5):e0126459. Epub 2015 May 11. PMID: 25961580

Click here to read the entire abstract

Pubmed Data : Free Radic Biol Med. 2015 Dec ;89:690-700. Epub 2015 Nov 4. PMID: 26456052

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2013 ;8(4):e62168. Epub 2013 Apr 17. PMID: 23614029

Article Published Date : Dec 31, 2012

Study Type : Animal Study

Additional Links

Substances : Mistletoe, Oleanolic acid

Diseases : Cancers: All, Malignant Melanoma, Melanoma

Pharmacological Actions : Anti-Angiogenic, Anti-Tumor, Antineoplastic Agents, Apoptotic

Additional Keywords : Natural Substance Synergy, Phytotherapy, Plant Extracts, Significant Treatment Outcome , Solubilized Triterpenoids

[+]

The combination of pterostilbene and lupeol was more effective in prevention of skin cancer as compared to either of the phytochemical alone.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2017 Jan ;99:182-189. Epub 2016 Nov 9. PMID: 27836749

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Cancer. 2011 Apr 15 ;128(8):1955-65. PMID: 20568104

Article Published Date : Apr 14, 2011

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Diseases : Chemotherapy-Induced Toxicity, Malignant Melanoma, Melanoma, Skin Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Chemotherapeutic

Additional Keywords : Natural Substance/Drug Antagonism, Natural Substance/Drug Synergy, Plant Leaves, Temozolomide

Problem Substances : Cisplatin, Doxorubicin, Paclitaxel

[+]

[+]

These results support use of the Malus sp. extract and rutin as skin photochemopreventive agents for topical application. May 17, 2020

Click here to read the entire abstract

Pubmed Data : Rejuvenation Res. 2020 May 18. Epub 2020 May 18. PMID: 32242497

Article Published Date : May 17, 2020

Study Type : Animal Study

Additional Links

Substances : Apple, Rutin

Diseases : Skin Cancer, Ultraviolet Radiation Induced Damage

Pharmacological Actions : Chemopreventive, Photoprotective

[+]

This animal study found that vitamin C depletion increased the growth and metastasis of melanoma cells. Nov 30, 2011

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Oncol. 2011 Dec ;33(4):226-30. PMID: 22217712

Article Published Date : Nov 30, 2011

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Melanoma: Metastasis, Skin Cancer, Vitamin C Deficiency

Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Antiproliferative , Interleukin-1 beta downregulation, Interleukin-6 Downregulation

Additional Keywords : Risk Factors

[+]

This preclinical study provides the biological and clinical rationale for using vitamin D in melanoma adjuvant therapy.Jan 10, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2017 Jan 11 ;7:40370. Epub 2017 Jan 11. PMID: 28074906

Click here to read the entire abstract

Pubmed Data : Photochem Photobiol. 2004 Feb;79(2):193-8. PMID: 15068032

Article Published Date : Feb 01, 2004

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Pycnogenol (Pine Bark)

Diseases : Skin Cancer: Prevention, Sunburn

Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Immunomodulatory

[+]

Topically applied bidi tobacco extract exhibits skin-promoting activity in mice.Jan 01, 1994

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Pubmed Data : J Cancer Res Clin Oncol. 1994;120(8):485-9. PMID: 8207047

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Pubmed Data : Environ Toxicol. 2015 Sep 29. Epub 2015 Sep 29. PMID: 26420756

Article Published Date : Sep 28, 2015

Study Type : Animal Study

Additional Links

Substances : Triptolide

Diseases : Melanoma

Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor

[+]

Tumor bearing mice treated five times with photodynamic therapy using acai oil in nanoemulsion showed tumor volume reduction of 82%.Dec 31, 2016

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Pubmed Data : J Photochem Photobiol B. 2017 Jan ;166:301-310. Epub 2016 Dec 9. PMID: 28024281

Article Published Date : Dec 31, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Acai

Diseases : Melanoma

Therapeutic Actions : Photodynamic therapy

Pharmacological Actions : Antiproliferative , Photosensitizing Agents

Additional Keywords : Plant Oils

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Vitamin C at high concentrations induces cytotoxicity in malignant melanoma but promotes tumor growth at low concentrations.Mar 29, 2017

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Pubmed Data : Mol Carcinog. 2017 Mar 30. Epub 2017 Mar 30. PMID: 28370562

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Pubmed Data : Pharm Biol. 2011 Sep ;49(9):955-61. Epub 2011 Jul 21. PMID: 21777042

Article Published Date : Aug 31, 2011

Study Type : Animal Study

Additional Links

Substances : Carrot

Diseases : Skin Cancer, Skin Cancer: Prevention

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive

Additional Keywords : Phytotherapy, Plant Extracts, Significant Treatment Outcome

[+]

Xanthohumol as a promising novel agent for the treatment of hepatic melanoma metastasis.Jan 28, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Shikonin inhibits proliferation of melanoma cells by MAPK pathway-mediated induction of apoptosis Jan 28, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biosci Rep. 2021 Jan 29 ;41(1). PMID: 33403388

Article Published Date : Jan 28, 2021

Study Type : In Vitro Study

Additional Links

Substances : Shikonin

Diseases : Melanoma

Pharmacological Actions : Antiproliferative , Apoptotic

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These findings suggest that high-dose ascorbate has an anticancer effect on canine melanoma cell lines in vitro.Nov 30, 2018

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Pubmed Data : Vet Comp Oncol. 2018 Dec ;16(4):616-621. Epub 2018 Sep 6. PMID: 30188000

Article Published Date : Nov 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Vitamin C

Diseases : Animal Cancers, Melanoma

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

"Curcumin targets fibroblast-tumor cell interactions in oral squamous cell carcinoma."Dec 12, 2012

Click here to read the entire abstract

Pubmed Data : Exp Cell Res. 2012 Dec 13. Epub 2012 Dec 13. PMID: 23247073

Article Published Date : Dec 12, 2012

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Skin Cancer: Squamous Cell

[+]

"Fucoidan from Sargassum sp. and Fucus vesiculosus reduces cell viability of lung carcinoma and melanoma cells in vitro and activates natural killer cells in mice in vivo."Sep 30, 2011

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2019 Apr 16 ;11(4). Epub 2019 Apr 16. PMID: 30995771

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2018 Feb-Mar;70(2):164-175. Epub 2018 Jan 4. PMID: 29300102

Article Published Date : Jan 31, 2018

Study Type : Review

Additional Links

Substances : Curcumin

Diseases : Melanoma

Pharmacological Actions : Chemopreventive

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View the Evidence: 763 Abstracts with Skin Cancer Research

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Coffee intake appears to exert a moderate protective effect against basal cell cancer development.Jul 06, 2016

Coffee intake was associated with reduced risk of oral, pharynx, liver, colon, prostate, endometrial cancer and melanoma, but increased lung cancer risk.Sep 25, 2016

Hypnotic drugs increase the risk of skin cancer.Sep 01, 2008

There is some evidence for the beneficial effects of regular coffee consumption on melanoma.Mar 31, 2016

This meta-analysis suggested that caffeinated coffee might have chemo-preventive effects against malignant melanoma.Dec 31, 2015

This meta-analysis suggested that caffeinated coffee might have chemopreventive effects against basal cell carcinoma.Nov 28, 2016

Mineral oil exposures also contribute to the incidence and mortality of lung, melanoma, and possibly esophageal and stomach cancers and of non-Hodgkin's lymphoma in aerospace workers.Oct 01, 2005

A Euphorbia peplus extract demonstrated it was beneficial in patients with non-melanoma skin cancers.Feb 28, 2011

A high vitamin D status may benefit prognosis in patients diagnosed with primary melanoma.Mar 22, 2017

Assessment of oxidative stress in tumors and histologically normal mucosa from patients with head and neck squamous cell carcinoma: a preliminary study.Mar 11, 2013

Citrus peel use and black tea intake reduce the risk of squamous cell carcinoma of the skin. Jan 01, 2001

consumption of caffeinated coffee was inversely associated with melanoma risk among men.Feb 19, 2017

Decreased vitamin D serum levels at melanoma diagnosis are associated with tumor ulceration and high tumor mitotic rate.Aug 27, 2019

Dl-alpha-tocopherol acetate does not protect against chemotherapy-induced chromosome damage and reduces the level of plasma gamma tocopherol.Feb 01, 2002

Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients.Apr 23, 2018

Fingolimod has been linked to a wide variety of side effects, including fatal viral infection.Feb 04, 2010

Gerson therapy may have therapeutic efficacy in the treatment of melanoma patients.Sep 01, 1995

Increased UVA exposures (indoor light) and decreased cutaneous Vitamin D(3) levels may be responsible for the increasing incidence of melanoma.Apr 01, 2009

Increasing caffeine intake and caffeinated coffee consumption is associated with decreased risk of cutaneous malignant melanomas.Jul 09, 2015

Low-grade squamous intra-epithelial cervical lesions spontaneously regress in 61% of females within 12 months and 91% within 36 months. Dec 13, 1901

Melanoma skin cancer rates increased with decreased levels of vitamin D.Apr 30, 2017

Photodynamic therapy for superficial basal cell carcinomas.Jan 14, 2022

Red and processed meat intake was inversely associated with melanoma risk in these two cohorts.Apr 22, 2018

Selaginella may induce radiosensitization on nasopharyngeal carcinoma and may reduce acute toxicity to healthy tissue..Feb 01, 2006

Solasodine glycoside cream is a safe therapy for basal cell carcinoma, with a cure rate of 66% at 8 weeks and 78% at 1 year follow-up.Jan 01, 2008

St. John's Wort in combination with photodynamic therapy demonstrates therapeutic effects in Actinic Keratosis, Basal Cell Carcinoma and Bowen's disease. May 01, 2008

Statin drug use is associated with increased incidence of melanoma and non-melanoma skin cancers. Oct 01, 2008

The authors of this study concluded that melanoma is associated with exposure to FM broadcasting.Jan 01, 2002

The data from the NOWAC Study indicate that a moderate intake of filtered coffee could reduce the risk of malignant melanoma.Jul 28, 2016

The Mediterranean Diet is associated with lower risk of skin cancer, Aug 05, 2019

The study suggests an augmented risk of cutaneous melanoma among subjects with exposure to pesticides.Mar 31, 2016

The use of prednisone and TNF inhibitor drugs in the treatment of rheumatoid arthritis is associated with an increased rate of non-melanoma skin cancer. Nov 01, 2005

The use of sildenafil may be associated with a higher risk of melanoma in men.May 31, 2014

These results suggest that coffee drinking may protect against liver, ovarian, thyroid and endometrial cancers and melanoma.May 17, 2018

This population based study that shows the relationship between arsenic intoxication and non-melanoma skin cancers.Aug 17, 2015

Turmeric and curcumin are therapeutic as topical agents in cancer therapy. Feb 28, 1987

Vitamin D deficiency in melanoma patients is associated with worse overall survival.Dec 31, 2021

A water extract of Withania somnifera has potent cytotoxic effect on human malignant melanoma A375 cells.Dec 31, 2014

An extract of Rosmarinus officinals L. was able to efficiently reduce the proliferation of the human melanoma A375 cells.Dec 31, 2014

Antiproliferative and proapoptotic effects of erucin, a diet-derived H2S donor, on human melanoma cells.Dec 25, 2022

Apigenin is a novel therapeutic candidate for melanoma.Feb 13, 2017

Blue LED irradiation induces apoptotic cell death by activating the mitochondria-mediated pathway and reduces the early growth rate of melanoma cells.Dec 31, 2014

Delta tocotrienol might represent an effective option for chemopreventive strategies for melanoma.Dec 31, 2015

The combination of HSP70 with phloretin could be a novel treatment for efficient immunotherapy of intractable cancers such as skin melanoma.Dec 31, 2015

The present study shows that lichen compounds demonstrated strong antioxidant, antimicrobial, and anticancer properties.Oct 14, 2012

This paper describes a tocotrienol nano emulsion with enhanced effectiveness against skin carcinomas.Jun 01, 2016

Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer.Jan 09, 2017

Zerumbone has chemotherapeutic effects on human melanoma cells by altering mitochondrial function.Mar 31, 2017

3,3'-Diindolylmethane improves antitumor immune responses of PD-1 blockade via inhibiting myeloid-derived suppressor cells.Jun 29, 2022

A patient with basal-cell epithelioma occurring in a smallpox vaccination site is reported.Apr 30, 1976

Basocellular carcinoma in a smallpox vaccination scar.Dec 31, 1987

Blue light promotes vitamin C-mediated ferroptosis of melanoma through specifically upregulating transporter SVCT2 and generating Fe2.May 30, 2023

Capsaicin exerts therapeutic effects by targeting tNOX-SIRT1 axis and augmenting ROS-dependent autophagy in melanoma cancer cells.Dec 31, 2020

Case of probable spontaneous regression of Merkel cell carcinoma combined with squamous cell carcinoma without surgical intervention.Jun 30, 2018

Complete spontaneous regression of multiple basal cell carcinomas in the basal cell nevus syndrome.Oct 31, 1990

Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells.Sep 30, 2022

Ginsenoside Re inhibits melanogenesis and melanoma growth.Aug 31, 2023

Long-term survival and spontaneous tumor regression in stage IV melanoma.May 31, 2010

Olive leaf extract inhibits metastatic melanoma spread through suppression of epithelial to mesenchymal transition.Sep 30, 2022

Regression of periocular basal cell carcinoma.Feb 29, 2020

Spontaneous regression of a middle ear melanoma. Sep 29, 2021

Squamous cell carcinoma in ulcer after bacille Calmette-Guérin vaccination.Oct 12, 2014

The presented case shows long-time survival in a patient with Merkel cell carcinoma treated with surgery and Viscum album injections.May 31, 2018

The use of Iscador as the sole modality for the adjuvant treatment of metastatic melanoma was extremely effective and very well tolerated achieving complete response and absence of all complaints.Apr 30, 2007

Viscum album extracts seems to have a positive potential in malignant cutaneous melanoma.Oct 31, 2017

Restoration of ascorbate from adequate to optimal physiological levels reduced tumor growth rates and moderated HIF-1 pathway activityJan 31, 2015

"Sulforaphane induces phase II detoxication enzymes in mouse skin and prevents mutagenesis induced by a mustard gas analog."Nov 29, 2012

1,8-cineole prevents UVB-induced skin carcinogenesis by targeting the aryl hydrocarbon receptor.Nov 30, 2017

2'-HCA potently suppressed the growth of mouse xenografts representing human leukemia or skin cancer.May 05, 2015

A lipid-soluble ginseng extract potently inhibited invasion and migration of B16F10 mouse melanoma cells in a dose-dependent manner.Dec 31, 2014

A multi-herbal product called Protandim exhibits chemopreventive properties in a mouse model of skin cancer. Jan 01, 2010

Skin Cancer

View the Evidence:
763 Abstracts with Skin Cancer Research