Spinal Cord Injuries

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92 Substances Researched for Spinal Cord Injuries
NameACCKFocus
Vitamin E230Locked
Curcumin924Locked
Vitamin C324Locked
Cannabidiol415Locked
Ginsenosides915Locked
Coenzyme Q10414Locked
Caffeic acid phenethyl ester212Locked
DHA (Docosahexaenoic Acid)212Locked
Selenium212Locked
Cannabis110Locked
Chlorella (Algae)110Locked
Creatine110Locked
Delta-tetrahydrocannabinol (THC)110Locked
EPA (Eicosapentaenoic Acid)110Locked
Honey110Locked
Marijuana110Locked
Melatonin510Locked
Vitamin B-12110Locked
Vitamin D110Locked
Whey110Locked
Puerarin48Locked
Resveratrol47Locked
Astaxanthin36Locked
Tanshinone IIA36Locked
Alpha-Lipoic Acid24Locked
Asiatic Acid24Locked
Bee Venom24Locked
Beta-Elemene24Locked
Catechin 24Locked
Folic Acid 24Locked
Geraniol 24Locked
Lycopene24Locked
Spirulina24Locked
Sulforaphane24Locked
Thymoquinone24Locked
Ayurvedic Formulations13Locked
Berberine23Locked
Daidzein23Locked
Green Tea23Locked
Palmitoylethanolamide 23Locked
Progesterone23Locked
Allicin12Locked
Apocynin12Locked
Arginine12Locked
Carnosol12Locked
Celastrol12Locked
Chinese Skullcap 12Locked
Chlorogenic Acid12Locked
Crocetin12Locked
Delphinidin12Locked
Echinacea12Locked
Epicatechin12Locked
Folate12Locked
Garlic: Aged12Locked
Gastrodin12Locked
Ginseng (American)12Locked
Hesperidin12Locked
Huperzine12Locked
Kaempferol12Locked
Licorice12Locked
Ligustrazine12Locked
Lutein12Locked
Luteolin12Locked
Magnesium12Locked
Magnesium Sulfate12Locked
Naringenin 12Locked
Nicotinamide adenine dinucleotide (NADH) 12Locked
Nigella sativa (aka Black Seed)12Locked
Oleanolic acid12Locked
Paeoniflorin12Locked
Panax Notoginseng12Locked
Propolis: Bee12Locked
Pycnogenol (Pine Bark)12Locked
Quercetin12Locked
Salvia miltiorrhiza12Locked
Shikonin12Locked
Taurine12Locked
Tetrahydrocurcumin12Locked
Theanine12Locked
Ursolic Acid12Locked
Vanillin12Locked
Zinc12Locked
Angelica11Locked
Citrus naringin11Locked
EGCG (Epigallocatechin gallate)11Locked
Estradiol (E(2))11Locked
Fisetin11Locked
Goji11Locked
Isoflavones11Locked
Pterostilbene11Locked
Rosemaric Acid11Locked
Rutin11Locked
2 Problem Substances Researched for Spinal Cord Injuries
NameACCKFocus
Simvastatin12Locked
Statin Drugs12Locked
9 Therapeutic Actions Researched for Spinal Cord Injuries
NameACCKFocus
Hyperbaric Treatment518Locked
Electroacupuncture815Locked
Acupuncture314Locked
Exercise: Aerobic110Locked
Yoga110Locked
Dietary Modification: Low Carbohydrate/Ketogenic23Locked
Laser Treatment: Low-Level12Locked
Light Therapy12Locked
Oxygen Therapy 12Locked
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View the Evidence:
218 Abstracts with Spinal Cord Injuries Research

[+]

Administration of vitamin C and vitamin E in animal models of spinal cord injury significantly improves the recovery of motor function.Dec 03, 2019

Pubmed Data : Nutr Rev. 2019 Dec 4. Epub 2019 Dec 4. PMID: 31800057
Article Published Date : Dec 03, 2019
Study Type : Meta Analysis, Review
Additional Links
Substances : Vitamin C, Vitamin E
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Electroacupuncture for spinal cord injury: a systematic review and meta-analysis.Dec 31, 2021

Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:8040555. Epub 2022 Mar 4. PMID: 35280510
Article Published Date : Dec 31, 2021
Study Type : Meta Analysis, Review
Additional Links
Diseases : Spinal Cord Injuries
Therapeutic Actions : Electroacupuncture
[+]

The potential of curcumin for treating spinal cord injury.May 03, 2022

Pubmed Data : Nutr Neurosci. 2022 May 4:1-12. Epub 2022 May 4. PMID: 35507337
Article Published Date : May 03, 2022
Study Type : Meta Analysis
Additional Links
Substances : Curcumin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Acupuncture may have therapeutic value in treating urinary incontinence associated with spinal cord injuries. Jan 01, 2000

Pubmed Data : Urol Int. 2000;65(4):190-5. PMID: 11112867
Article Published Date : Jan 01, 2000
Study Type : Human Study
Additional Links
Diseases : Incontinence: Urinary, Spinal Cord Injuries
Therapeutic Actions : Acupuncture
[+]

Cannabis extracts can be considered an alternative in patients with spasticity associated with chronic spinal cord injury.Sep 30, 2017

Pubmed Data : Rev Neurol. 2017 Oct 1 ;65(7):295-302. PMID: 28929471
Article Published Date : Sep 30, 2017
Study Type : Human Study
Additional Links
Substances : Cannabidiol, Cannabis, Delta-tetrahydrocannabinol (THC)
Diseases : Spinal Cord Injuries
Additional Keywords : Plant Extracts
[+]

Capsaicin 8% patch for spinal cord injury focal neuropathic pain.Jul 06, 2022

Pubmed Data : Pain Med. 2022 Jul 7. Epub 2022 Jul 7. PMID: 35799365
Article Published Date : Jul 06, 2022
Study Type : Human Study
Additional Links
Substances : Capsaicin
Diseases : Neuropathic Pain, Spinal Cord Injuries
Pharmacological Actions : Analgesics
[+]

Clinical meditation and imagery is feasible and acceptable to implement with people with SCI and chronic pain.Oct 05, 2021

Pubmed Data : J Spinal Cord Med. 2021 Oct 6:1-15. Epub 2021 Oct 6. PMID: 34612802
Article Published Date : Oct 05, 2021
Study Type : Human Study
Additional Links
Diseases : Chronic Pain, Spinal Cord Injuries
Therapeutic Actions : Meditation
Pharmacological Actions : Antinoceceptive
[+]

Cranberry extract prevents urinary tract infections in spinal cord injured patients with neurogenic bladder. Sep 01, 2008

Pubmed Data : Spinal Cord. 2008 Sep;46(9):622-6. Epub 2008 Apr 8. PMID: 18392039
Article Published Date : Sep 01, 2008
Study Type : Human Study
Additional Links
Diseases : Neurogenic Bladder, Spinal Cord Injuries, Urinary Tract Infections
Additional Keywords : Plant Extracts, Proanthocyanidins
[+]

Hyperbaric oxygen therapy regulated the inflammatory reaction in secondary spinal cord injury.Oct 31, 2018

Pubmed Data : Neurosci Lett. 2018 Nov 1 ;692:47-52. Epub 2018 Nov 1. PMID: 30391318
Article Published Date : Oct 31, 2018
Study Type : Human Study
Additional Links
Diseases : Spinal Cord Injuries
Therapeutic Actions : Hyperbaric Treatment
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Intrathecal CAPE following spinal cord injury decreases tissue and serum IL-6 levels as well as decreases spinal cord edema and microhemorrhage.Dec 31, 2017

Pubmed Data : Turk Neurosurg. 2018 ;28(4):625-629. PMID: 30192364
Article Published Date : Dec 31, 2017
Study Type : Human Study
Additional Links
Substances : Caffeic acid phenethyl ester
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Patients with spinal cord injuries and chronic pressure ulcers were treated with Medihoney with significant wound healing and infection control with soft and elastic scars. Jan 31, 2012

Pubmed Data : Spinal Cord. 2012 Feb ;50(2):165-9. Epub 2011 Sep 20. PMID: 21931331
Article Published Date : Jan 31, 2012
Study Type : Human Study
Additional Links
Substances : Honey
Diseases : Pressure Ulcer, Spinal Cord Injuries
[+]

Supplementation with creatine may improve muscle strength parameters in individuals with spinal cord injury.Sep 12, 2017

Pubmed Data : J Spinal Cord Med. 2017 Sep 13:1-8. Epub 2017 Sep 13. PMID: 28901216
Article Published Date : Sep 12, 2017
Study Type : Human Study
Additional Links
Substances : Creatine, Vitamin D
Diseases : Spinal Cord Injuries, Vitamin D Deficiency
Additional Keywords : Risk Reduction
[+]

Targeting inflammation through diet in patients after spinal cord injury could help with depressive symptoms. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neuroinflammation. 2015 ;12(1):204. Epub 2015 Nov 6. PMID: 26545369
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Substances : Chlorella (Algae), Coenzyme Q10, Curcumin, DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid), Selenium, Vitamin E
Diseases : Depression, Spinal Cord Inflammation, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents
Additional Keywords : Dietary Modification, Diseases that are Linked, Supplementation
[+]

The effects of acute aerobic exercise on mood and inflammation in individuals with multiple sclerosis and incomplete spinal cord injury.Aug 18, 2019

Pubmed Data : NeuroRehabilitation. 2019 Aug 19. Epub 2019 Aug 19. PMID: 31450521
Article Published Date : Aug 18, 2019
Study Type : Human Study
Additional Links
Diseases : Inflammation, Multiple Sclerosis, Spinal Cord Injuries
Therapeutic Actions : Exercise: Aerobic
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Vitamin B12 deficiency may aggravate spinal cord injuries. Jan 01, 2003

Pubmed Data : J Spinal Cord Med. 2003;26(2):116-21. PMID: 12828286
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Substances : Vitamin B-12
Diseases : Spinal Cord Injuries, Vitamin B 12 Deficiency
Additional Keywords : Diseases that are Linked
[+]

Whey protein may have therapeutic value in persons with incomplete spinal cord injuries.Feb 01, 2007

Pubmed Data : Arch Phys Med Rehabil. 2007 Feb;88(2):228-33. PMID: 17270521
Article Published Date : Feb 01, 2007
Study Type : Human Study
Additional Links
Substances : Whey
Diseases : Spinal Cord Injuries
[+]

Whole-plant cannabis extract can improve intractable neurogenic symptoms. Feb 01, 2003

Pubmed Data : Clin Rehabil. 2003 Feb;17(1):21-9. PMID: 12617376
Article Published Date : Feb 01, 2003
Study Type : Human Study
Additional Links
Substances : Marijuana
Diseases : Brachial Plexus Neuropathies, Multiple Sclerosis, Neurogenic Bladder, Phantom Limb, Spinal Cord Injuries
[+]

Yoga intervention reduced depressive symptoms and increased self-compassion in individuals with spinal cord injury.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pain Res. 2017 ;10:999-1017. Epub 2017 May 3. PMID: 28496356
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Diseases : Depression, Spinal Cord Injuries
Therapeutic Actions : Yoga
Pharmacological Actions : Antidepressive Agents
[+]

Immediate therapeutic hypothermia and hyperbaric oxygen therapy could reverse spinal ischemia injury. Dec 31, 2016

Pubmed Data : Vasc Endovascular Surg. 2017 Jan 1:1538574417725238. Epub 2017 Jan 1. PMID: 28820047
Article Published Date : Dec 31, 2016
Study Type : Human: Case Report
Additional Links
Diseases : Ischemia, Spinal Cord Injuries
Therapeutic Actions : Hyperbaric Treatment
[+]

Substantial clinical improvement was reported after 2 months of the Ayurvedic treatment in existing neurological deficits and in quality of life.Mar 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anc Sci Life. 2015 Apr-Jun;34(4):230-4. PMID: 26283809
Article Published Date : Mar 31, 2015
Study Type : Human: Case Report
Additional Links
Substances : Ayurvedic Formulations
Diseases : Quality of Life: Poor, Spinal Cord Injuries
[+]

Improved spinal cord gray matter morphology induced by Spirulina platensis following spinal cord injury in rat models.Jul 19, 2020

Pubmed Data : Ultrastruct Pathol. 2020 Jul 20:1-13. Epub 2020 Jul 20. PMID: 32686973
Article Published Date : Jul 19, 2020
Study Type : Animal Study
Additional Links
Substances : Spirulina
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Pycnogenol achieves neuroprotective effects in rats with spinal cord injury by stabilizing the mitochondrial membrane potential.Jun 30, 2020

Pubmed Data : Neurol Res. 2020 Jul ;42(7):597-604. Epub 2020 Jun 4. PMID: 32497471
Article Published Date : Jun 30, 2020
Study Type : Animal Study
Additional Links
Substances : Pycnogenol (Pine Bark)
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Resveratrol promotes axonal regeneration after spinal cord injury through activating Wnt/β-catenin signaling pathway.Oct 13, 2021

Pubmed Data : Aging (Albany NY). 2021 Oct 14 ;13(undefined). Epub 2021 Oct 14. PMID: 34647904
Article Published Date : Oct 13, 2021
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Nerve Regeneration
[+]

"Neuroprotective effects of sulforaphane after contusive spinal cord injury."Oct 31, 2012

Pubmed Data : J Neurotrauma. 2012 Nov 1 ;29(16):2576-86. Epub 2012 Sep 20. PMID: 22853439
Article Published Date : Oct 31, 2012
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

5-HT 7 receptor is involved in electroacupuncture inhibition of chronic pain in the spinal cord.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurosci. 2021 ;15:733779. Epub 2021 Sep 17. PMID: 34602973
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Diseases : Chronic Pain, Spinal Cord Injuries
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Analgesics
[+]

A green tea polyphenol epigallocatechin-3-gallate enhances neuroregeneration after spinal cord injury by altering levels of inflammatory cytokines.Nov 29, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2018 Nov 29 ;19(12). Epub 2018 Nov 29. PMID: 30501071
Article Published Date : Nov 29, 2018
Study Type : Animal Study
Additional Links
Substances : Catechin , Green Tea
Diseases : Brain Damage, Neurodegenerative Diseases, Spinal Cord Injuries
Pharmacological Actions : Regenerative
[+]

Acteoside improves muscle atrophy and motor function.Jan 14, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neurotrauma. 2019 06 15 ;36(12):1935-1948. Epub 2019 Jan 10. PMID: 30318996
Article Published Date : Jan 14, 2019
Study Type : Animal Study
Additional Links
Substances : Verbascoside
Diseases : Muscle Atrophy , Spinal Cord Injuries
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Administration of chlorogenic acid alleviates spinal cord injury.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2018 Jan ;17(1):1340-1346. Epub 2017 Nov 6. PMID: 29115619
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Chlorogenic Acid
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents, NF-kappaB Inhibitor
[+]

Aged garlic extract attenuates neuronal injury in a rat model of spinal cord ischemia/reperfusion injury.May 31, 2016

Pubmed Data : J Med Food. 2016 Jun ;19(6):601-6. Epub 2016 May 16. PMID: 27183321
Article Published Date : May 31, 2016
Study Type : Animal Study
Additional Links
Substances : Garlic: Aged
Diseases : Ischemia, Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Plant Extracts
[+]

Allicin could be used in protection in traumatic spinal cord injury.Sep 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2016 Oct ;14(4):3086-92. Epub 2016 Aug 19. PMID: 27573340
Article Published Date : Sep 30, 2016
Study Type : Animal Study
Additional Links
Substances : Allicin
Diseases : Oxidative Stress, Spinal Cord Injuries
Pharmacological Actions : Antioxidants, Heat Shock Protein Inducer, Neuroprotective Agents
Additional Keywords : Allicin, Antioxidants, Heat Shock Protein Inducer, Neuroprotective Agents, oxidative stress, Spinal Cord Injuries
[+]

Alpha lipoic acid has a beneficial effect in improving the bladder tonus following spinal cord injury.Aug 03, 2016

Pubmed Data : Neurourol Urodyn. 2016 Aug 4. Epub 2016 Aug 4. PMID: 27490041
Article Published Date : Aug 03, 2016
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Malondialdehyde Down-regulation
[+]

Ameliorative effects of echinacoside against spinal cord injury.Nov 14, 2019

Pubmed Data : Life Sci. 2019 Nov 15 ;237:116978. Epub 2019 Oct 20. PMID: 31644893
Article Published Date : Nov 14, 2019
Study Type : Animal Study
Additional Links
Substances : Echinacea
Diseases : Inflammation, Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Anti-inflammatory and antioxidant effects of astaxanthin following spinal cord injury.Oct 20, 2021

Pubmed Data : Brain Res Bull. 2021 Oct 21. Epub 2021 Oct 21. PMID: 34688832
Article Published Date : Oct 20, 2021
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Antioxidative effects of alpha-lipoic acid in spinal cord injury.Dec 31, 2020

Pubmed Data : Ann Ital Chir. 2021 ;92:98-102. PMID: 33746123
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Spinal Cord Injuries
Pharmacological Actions : Antioxidants
[+]

Astaxanthin attenuates neuroinflammation contributed to the neuropathic pain and motor dysfunction following compression spinal cord injury.Sep 18, 2018

Pubmed Data : Brain Res Bull. 2018 Sep 19. Epub 2018 Sep 19. PMID: 30243665
Article Published Date : Sep 18, 2018
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Brain Inflammation , Spinal Cord Inflammation, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Astaxanthin can inhibit the lipid peroxidation, reduce the apoptosis, reduce the spinal cord edema.Apr 30, 2018

Pubmed Data : Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2018 May 1 ;32(5):548-553. PMID: 29806341
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Hypolipidemic, Neuroprotective Agents
[+]

Astaxanthin modulates autophagy, apoptosis, and neuronal oxidative stress in a rat model of compression spinal cord injury.Apr 17, 2022

Pubmed Data : Neurochem Res. 2022 Apr 18. Epub 2022 Apr 18. PMID: 35435619
Article Published Date : Apr 17, 2022
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Astaxanthin reduces neuronal apoptosis, diminishes pathological tissue damage and improves functional recovery after spinal cord injury.Apr 21, 2017

Pubmed Data : Behav Brain Res. 2017 Apr 22. Epub 2017 Apr 22. PMID: 28442361
Article Published Date : Apr 21, 2017
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Astaxanthin significantly improved the motor function of rats with spinal cord injury.Nov 30, 2021

Pubmed Data : Ann Transl Med. 2021 Dec ;9(24):1796. PMID: 35071490
Article Published Date : Nov 30, 2021
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Baicalin attenuates blood-spinal cord barrier disruption and apoptosis through PI3K/Akt signaling pathway after spinal cord injury.Apr 30, 2022

Pubmed Data : Neural Regen Res. 2022 May ;17(5):1080-1087. PMID: 34558536
Article Published Date : Apr 30, 2022
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Bee venom acupuncture can reduce neuroinflammation and induce recovery in the spinal cord injuries compression model.May 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Acupunct Meridian Stud. 2017 Jun ;10(3):204-210. Epub 2017 Apr 21. PMID: 28712480
Article Published Date : May 31, 2017
Study Type : Animal Study
Additional Links
Substances : Bee Venom
Diseases : Spinal Cord Injuries
Therapeutic Actions : Acupuncture
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation
[+]

Berberine-loaded M2 macrophage-derived exosomes for spinal cord injury therapy.Mar 11, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Biomater. 2021 Mar 12. Epub 2021 Mar 12. PMID: 33722788
Article Published Date : Mar 11, 2021
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Exosomes
[+]

Beta-elemene reduces neuronal apoptosis by alleviating endoplasmic reticulum stress in vitro and in vivo.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2018 ;49(2):595-609. Epub 2018 Aug 30. PMID: 30165357
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Beta-Elemene
Diseases : Spinal Cord Injuries
Pharmacological Actions : Apoptotic
[+]

Better neuroprotective profile of caffeic acid phenyl ester over resveratrol in non-traumatic ischemia-reperfusion injury of the spinal cord.Dec 08, 2021

Pubmed Data : Br J Neurosurg. 2021 Dec 9:1-7. Epub 2021 Dec 9. PMID: 34879774
Article Published Date : Dec 08, 2021
Study Type : Animal Study
Additional Links
Substances : Caffeic acid phenethyl ester
Diseases : Ischemia, Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Cannabidiol attenuates hypersensitivity and oxidative stress after traumatic spinal cord injury.Jan 24, 2022

Pubmed Data : Neurosci Lett. 2022 09 25 ;788:136855. Epub 2022 Aug 23. PMID: 36028005
Article Published Date : Jan 24, 2022
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Oxidative Stress, Spinal Cord Injuries
Pharmacological Actions : Analgesics, Antioxidants
[+]

Carnosol protects against spinal cord injury through Nrf-2 upregulation.Dec 31, 2015

Pubmed Data : J Recept Signal Transduct Res. 2016 ;36(1):72-8. Epub 2015 Jul 6. PMID: 26791582
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Carnosol
Diseases : Oxidative Stress, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Nrf2 activation
[+]

CBD administration attenuated spinal cord injury induced sublesional cancellous bone loss.May 03, 2017

Pubmed Data : Eur J Pharmacol. 2017 May 4. Epub 2017 May 4. PMID: 28479140
Article Published Date : May 03, 2017
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Spinal Cord Injuries
Pharmacological Actions : Osteoprotective
[+]

CBD treatment attenuated the development of thermal sensitivity following spinal cord injury.Mar 07, 2018

Pubmed Data : Cell Immunol. 2018 Mar 8. Epub 2018 Mar 8. PMID: 29784129
Article Published Date : Mar 07, 2018
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Spinal Cord Inflammation, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Celastrol inhibits microglial pyroptosis and attenuates inflammatory reaction in acute spinal cord injury rats.Dec 31, 2018

Pubmed Data : Int Immunopharmacol. 2019 Jan ;66:215-223. Epub 2018 Nov 22. PMID: 30472522
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Celastrol
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Chinese skullcap (Scutellaria baicalensis) significantly improves functional recovery from spinal cord injury in rats by inhibiting inflammation and oxidative stress after injury.Aug 01, 2009

Pubmed Data : J Neurochem. 2009 Aug;110(4):1276-87. Epub 2009 Jun 10. PMID: 19519665
Article Published Date : Aug 01, 2009
Study Type : Animal Study
Additional Links
Substances : Chinese Skullcap
Diseases : Brain: Microglial Activation, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Apoptotic, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Nitric Oxide Inhibitor
Additional Keywords : Plant Extracts
[+]

Co-ultramicronized palmitoylethanolamide and luteolin promotes neuronal regeneration after spinal cord injury.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2016 ;7:47. Epub 2016 Mar 8. PMID: 27014061
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Luteolin, Palmitoylethanolamide
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents, Regenerative
Additional Keywords : regen
[+]

Coenzyme Q10 influences on the levels of TNF-α and IL-10 and the ratio of Bax/Bcl2 in a menopausal rat model following lumbar spinal cord injury.May 31, 2018

Pubmed Data : J Mol Neurosci. 2018 Jun ;65(2):255-264. Epub 2018 Jun 14. PMID: 29948851
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Coenzyme Q10
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Bax/Bcl2 Ratio: Decrease, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Combing sinomenine and gabapentin or ligustrazine hydrochloride could be highly beneficial in neuropathic pain therapies.Jul 04, 2019

Pubmed Data : Eur J Pharmacol. 2019 Jul 5 ;854:101-108. Epub 2019 Apr 4. PMID: 30954565
Article Published Date : Jul 04, 2019
Study Type : Animal Study
Additional Links
Substances : Sinomenine
Diseases : Neuropathic Pain, Sciatica, Spinal Cord Injuries
Pharmacological Actions : Analgesics
Additional Keywords : Natural Substance/Drug Synergy
[+]

Crocetin promotes neurite growth and facilitates the recovery of motor and sensorimotor functions after spinal cord injury.Aug 01, 2017

Pubmed Data : Neurosci Bull. 2017 Aug 2. Epub 2017 Aug 2. PMID: 28770439
Article Published Date : Aug 01, 2017
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuritogenic
[+]

Curcumin can attenuate the downregulation of CISD2 in spinal cord injuries and LPS-treated astrocytes.Aug 07, 2015

Pubmed Data : Injury. 2015 Aug 8. Epub 2015 Aug 8. PMID: 26387034
Article Published Date : Aug 07, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Brain Inflammation , Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, MicroRNA modulator, Neuroprotective Agents
[+]

Curcumin could have a role in promoting neural function recovery after SCI by the joint inhibition of the intracellular and extracellular components of glial scar.Apr 30, 2015

Pubmed Data : J Surg Res. 2015 May 1 ;195(1):235-45. Epub 2015 Jan 7. PMID: 25661742
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Curcumin has a profound anti-inflammatory therapeutic potential in the treatment of spinal cord injury.Dec 31, 2015

Pubmed Data : Int J Mol Sci. 2016 ;17(1). Epub 2015 Dec 31. PMID: 26729105
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-2 Downregulation, NF-kappaB Inhibitor
[+]

Curcumin has a protective effect after spinal cord injury. Aug 05, 2009

Pubmed Data : J Surg Res. 2009 Aug 5. Epub 2009 Aug 5. PMID: 20018302
Article Published Date : Aug 05, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Curcumin improves early functional results after experimental spinal cord injury.Sep 01, 2010

Pubmed Data : Acta Neurochir (Wien). 2010 Sep;152(9):1583-90; discussion 1590. Epub 2010 Jun 10. PMID: 20535508
Article Published Date : Sep 01, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Curcumin may stimulate recovery from spinal cord injury. Feb 10, 2012

Pubmed Data : J Neurosurg Spine. 2012 Feb 10. Epub 2012 Feb 10. PMID: 22324804
Article Published Date : Feb 10, 2012
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Regenerative Substances
[+]

Daidzein ameliorates spinal cord ischemia/reperfusion injury-induced neurological function deficits.Oct 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2017 Nov ;14(5):4878-4886. Epub 2017 Sep 21. PMID: 29201192
Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Daidzein
Diseases : Ischemia, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Dl-3-n-butylphthalide attenuates spinal cord injury.Aug 31, 2021

Pubmed Data : Neurochem Res. 2021 Sep ;46(9):2297-2306. Epub 2021 Jun 4. PMID: 34086144
Article Published Date : Aug 31, 2021
Study Type : Animal Study
Additional Links
Substances : Celery Oil
Diseases : Hypoxia, Spinal Cord Injuries
Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Neuroprotective Agents
[+]

Effect of propolis on neurological recovery after experimental spinal cord injury.Dec 31, 2020

Pubmed Data : Turk Neurosurg. 2021 ;31(1):93-98. PMID: 33491171
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Propolis: Bee
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Effects of electroacupuncture on motor function and calpain expression in rats with acute spinal cord injury.Dec 24, 2020

Pubmed Data : Zhen Ci Yan Jiu. 2020 Dec 25 ;45(12):968-72. PMID: 33415854
Article Published Date : Dec 24, 2020
Study Type : Animal Study
Additional Links
Diseases : Spinal Cord Injuries
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Neuroprotective Agents
[+]

Efficacy of Annona muricata in experimental spinal cord injury.Feb 28, 2022

Pubmed Data : Ulus Travma Acil Cerrahi Derg. 2022 Mar ;28(3):233-241. PMID: 35485570
Article Published Date : Feb 28, 2022
Study Type : Animal Study
Additional Links
Substances : Soursop
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

EGCG, the green tea polyphenol, has a protective effecto spinal cord injuries and improves functional recovery. Jan 08, 2010

Pubmed Data : Brain Res. 2010 Jan 8;1306:168-75. Epub 2009 Oct 6. PMID: 19815005
Article Published Date : Jan 08, 2010
Study Type : Animal Study
Additional Links
Substances : Catechin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Electro-acupuncture promotes differentiation of mesenchymal stem cells, regeneration of nerve fibers and partial functional recovery after spinal cord injury.Dec 10, 2009

Pubmed Data : Exp Toxicol Pathol. 2009 Dec 10. PMID: 20005688
Article Published Date : Dec 10, 2009
Study Type : Animal Study
Additional Links
Diseases : Spinal Cord Injuries
Therapeutic Actions : Electroacupuncture
[+]

Electro-acupuncture promotes survival, differentiation of the bone marrow mesenchymal stem cells as well as functional recovery in the spinal cord-transected rats.Jan 01, 2009

Pubmed Data : BMC Neurosci. 2009;10:35. Epub 2009 Apr 20. PMID: 19374777
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Diseases : Spinal Cord Injuries
Therapeutic Actions : Electroacupuncture
Additional Keywords : Regenerative Actions
[+]

Electroacupuncture improves locomotor function by regulating expression of inflammation and oxidative stress-related proteins in mice with spinal cord injury.Nov 24, 2019

Pubmed Data : Zhen Ci Yan Jiu. 2019 Nov 25 ;44(11):781-6. PMID: 31777225
Article Published Date : Nov 24, 2019
Study Type : Animal Study
Additional Links
Diseases : Inflammation, Oxidative Stress, Spinal Cord Injuries
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Electroacupuncture in promoting neural repair after spinal cord injury.Oct 31, 2021

Pubmed Data : Anat Rec (Hoboken). 2021 Nov ;304(11):2494-2505. Epub 2021 Oct 12. PMID: 34636492
Article Published Date : Oct 31, 2021
Study Type : Animal Study
Additional Links
Diseases : Spinal Cord Injuries
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Nerve Regeneration
[+]

Electroacupuncture inhibits NLRP3 activation by regulating CMPK2 after spinal cord injury.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2022 ;13:788556. Epub 2022 Mar 24. PMID: 35401582
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Diseases : Spinal Cord Injuries
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
[+]

Electroacupuncture promoted axonal regeneration in spinal cord injury.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neuropsychiatr Dis Treat. 2019 ;15:3429-3442. Epub 2019 Dec 13. PMID: 31997879
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Diseases : Spinal Cord Injuries
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Nerve Regeneration
[+]

Epicatechin reduces muscle waste after complete spinal cord transection.Nov 04, 2020

Pubmed Data : Mol Biol Rep. 2020 Nov 5. Epub 2020 Nov 5. PMID: 33151476
Article Published Date : Nov 04, 2020
Study Type : Animal Study
Additional Links
Substances : Epicatechin
Diseases : Muscle Atrophy , Spinal Cord Injuries
[+]

Eriodictyol corrects functional recovery and myelin loss in spinal cord injuries.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Transl Neurosci. 2020 ;11(1):439-446. Epub 2020 Dec 31. PMID: 33680506
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Eriodictyol
Diseases : Spinal Cord Injuries
Pharmacological Actions : Brain-derived neurotrophic factor modulator, Neuroprotective Agents
[+]

Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation.Apr 30, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Invest. 2010 May ;120(5):1603-16. Epub 2010 Apr 26. PMID: 20424322
Article Published Date : Apr 30, 2010
Study Type : Animal Study
Additional Links
Substances : Folate, Folic Acid
Diseases : Brain Injury: Traumatic, Spinal Cord Injuries
Pharmacological Actions : Regenerative
Additional Keywords : DNA Methylation, Nerve Regeneration
[+]

Folic acid modulates matrix metalloproteinase-9 expression following spinal cord injury.Mar 31, 2019

Pubmed Data : Ann Neurosci. 2019 Apr ;26(2):60-65. Epub 2019 Apr 1. PMID: 31975775
Article Published Date : Mar 31, 2019
Study Type : Animal Study
Additional Links
Substances : Folic Acid
Diseases : Spinal Cord Injuries
Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Gastrodin ameliorates spinal cord injury via antioxidant and anti-inflammatory effects.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Biochim Pol. 2016 ;63(3):589-93. Epub 2016 Jul 30. PMID: 27474401
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Oxidative Stress, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Genistein protects against spinal cord injury.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Appl Bionics Biomech. 2022 ;2022:4790344. Epub 2022 Apr 22. PMID: 35498148
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Genistein
Diseases : Brain Inflammation , Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Geraniol has a protective effect in traumatic injury of the spinal cord. Nov 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2016 Dec ;12(6):3607-3613. Epub 2016 Oct 27. PMID: 28105094
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Geraniol
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants
[+]

Geraniol significantly promoted the recovery of neuronal function and attenuated neuropathic pain after spinal cord injury.Nov 30, 2017

Pubmed Data : Can J Physiol Pharmacol. 2017 Dec ;95(12):1389-1395. Epub 2017 Mar 23. PMID: 28334550
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Geraniol
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ginsenoside GRb1 could reduce the cell apoptosis induced by spinal cord ischemia-reperfusion through inhibiting oxidative stress.Aug 13, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Orthop Surg Res. 2019 Aug 14 ;14(1):259. Epub 2019 Aug 14. PMID: 31412899
Article Published Date : Aug 13, 2019
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Ischemia, Spinal Cord Injuries
Pharmacological Actions : Antioxidants
[+]

Ginsenoside Rb1 has beneficial effects on oxidative stress injury in rat spinal cords.Jul 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2018 Aug ;16(2):1079-1086. Epub 2018 Jun 12. PMID: 30116359
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Spinal Cord Injuries
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Ginsenoside Rb1 protects against spinal cord ischemia-reperfusion injury.Sep 01, 2018

Pubmed Data : Exp Mol Pathol. 2018 Sep 2 ;105(3):229-235. Epub 2018 Sep 2. PMID: 30184471
Article Published Date : Sep 01, 2018
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Ischemia, Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic
[+]

Ginsenoside Rd inhibits apoptosis following spinal cord ischemia/reperfusion injury.Sep 14, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Regen Res. 2014 Sep 15 ;9(18):1678-87. PMID: 25374589
Article Published Date : Sep 14, 2014
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Ischemia, Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Ginsenoside Rg1 inhibits oxidative stress and inflammation in rats with spinal cord injury.Jan 18, 2022

Pubmed Data : Neuroreport. 2022 01 19 ;33(2):81-89. PMID: 34954769
Article Published Date : Jan 18, 2022
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Inflammation, Oxidative Stress, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation
[+]

Ginsenoside Rg1 may represent a novel treatment target for spinal cord injury.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2017 ;40(10):1630-1637. PMID: 28966235
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Spinal Cord Injuries
Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Glycyrrhizin extract reduces the development of inflammation and tissue injury events associated with spinal cord trauma.Apr 01, 2009

Pubmed Data : Shock. 2009 Apr;31(4):367-75. PMID: 18665052
Article Published Date : Apr 01, 2009
Study Type : Animal Study
Additional Links
Substances : Licorice
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Grape seed proanthocyanidins exert a neuroprotective effect by regulating microglial M1/M2 polarisation in rats with spinal cord injury.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mediators Inflamm. 2022 ;2022:2579003. Epub 2022 Aug 4. PMID: 35966334
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents, NF-kappaB Inhibitor
Additional Keywords : Proanthocyanidins
[+]

Gut dysbiosis could impair recovery after spinal cord injury.Oct 16, 2016

Pubmed Data : J Exp Med. 2016 Oct 17. Epub 2016 Aug 17. PMID: 27810921
Article Published Date : Oct 16, 2016
Study Type : Animal Study
Additional Links
Diseases : Dysbiosis, Spinal Cord Injuries
Additional Keywords : Microbiota, Risk Factors
[+]

Hesperidin improves motor disability in rat spinal cord injury.Jan 09, 2020

Pubmed Data : Neurosci Lett. 2020 Jan 10 ;715:134619. Epub 2019 Nov 9. PMID: 31715292
Article Published Date : Jan 09, 2020
Study Type : Animal Study
Additional Links
Substances : Hesperidin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Honokiol exerts protective effects on neural myelin sheaths after compressed spinal cord injury.Apr 07, 2021

Pubmed Data : J Spinal Cord Med. 2021 Apr 8:1-10. Epub 2021 Apr 8. PMID: 33830903
Article Published Date : Apr 07, 2021
Study Type : Animal Study
Additional Links
Substances : Honokiol
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Huperzine A treatment demonstrates a significant reduction in the number of apoptotic cells in a model of spinal cord injury.Mar 31, 2018

Pubmed Data : J Neurosurg Sci. 2018 Apr ;62(2):128-139. Epub 2015 Oct 16. PMID: 26472141
Article Published Date : Mar 31, 2018
Study Type : Animal Study
Additional Links
Substances : Huperzine
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Hyperbaric oxygen therapy after acute thoracic spinal cord injury leads to improvement of locomotor recovery in rats.Aug 22, 2017

Pubmed Data : Spine (Phila Pa 1976). 2017 Aug 23. Epub 2017 Aug 23. PMID: 28837532
Article Published Date : Aug 22, 2017
Study Type : Animal Study
Additional Links
Diseases : Spinal Cord Injuries
Therapeutic Actions : Hyperbaric Treatment
[+]

Intrathecal CAPE administration following SCI decreases tissue and serum IL-6 levels as well as decreases spinal cord edema and microhemorrage.Apr 26, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Turk Neurosurg. 2017 Apr 27. Epub 2017 Apr 27. PMID: 28585671
Article Published Date : Apr 26, 2017
Study Type : Animal Study
Additional Links
Substances : Caffeic acid phenethyl ester
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation
[+]

Intravenous infusion of magnesium reduced potentially neurotoxic glutamate levels.Aug 07, 2016

Pubmed Data : J Neurotrauma. 2016 Aug 8. Epub 2016 Aug 8. PMID: 27503053
Article Published Date : Aug 07, 2016
Study Type : Animal Study
Additional Links
Substances : Magnesium
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Investigation of the effects of berberine on bortezomib-induced sciatic nerve and spinal cord damage.Jan 31, 2022

Pubmed Data : Neurotoxicology. 2022 Feb 1 ;89:127-139. Epub 2022 Feb 1. PMID: 35121005
Article Published Date : Jan 31, 2022
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Kaempferol might be a novel promising therapeutic agent for spinal cord injury.Apr 02, 2021

Pubmed Data : Free Radic Biol Med. 2021 Apr 3 ;168:142-154. Epub 2021 Apr 3. PMID: 33823244
Article Published Date : Apr 02, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Kaempferol
Diseases : Inflammation, Oxidative Stress, Spinal Cord Injuries
Pharmacological Actions : Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Neuroprotective Agents, NF-kappaB Inhibitor
[+]

Ketogenic metabolism inhibits histone deacetylase and reduces oxidative stress after spinal cord injury.Dec 15, 2017

Pubmed Data : Neuroscience. 2017 Dec 16 ;366:36-43. Epub 2017 Oct 9. PMID: 29024787
Article Published Date : Dec 15, 2017
Study Type : Animal Study
Additional Links
Diseases : Spinal Cord Injuries
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Malondialdehyde Down-regulation, Neuroprotective Agents
[+]

L-arginine reverses alterations in drug disposition induced by spinal cord injury by increasing hepatic blood flow.Dec 01, 2007

Pubmed Data : J Neurotrauma. 2007 Dec;24(12):1855-62. PMID: 18159997
Article Published Date : Dec 01, 2007
Study Type : Animal Study
Additional Links
Substances : Arginine
Diseases : Spinal Cord Injuries
Pharmacological Actions : Nitric Oxide Enhancer, Vasodilator Agents
[+]

l-Theanine improves functional recovery after traumatic spinal cord injury in rats.Dec 04, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Formos Med Assoc. 2019 Dec 5. Epub 2019 Dec 5. PMID: 31812333
Article Published Date : Dec 04, 2019
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Malondialdehyde Down-regulation, Neuroprotective Agents, Nitric Oxide Inhibitor
[+]

Low-level laser therapy at higher doses was effective in promoting functional recovery in the spinal cord of rats after spinal cord injury.Jan 31, 2017

Pubmed Data : Lasers Med Sci. 2017 Feb ;32(2):343-349. Epub 2016 Dec 1. PMID: 27909916
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Diseases : Spinal Cord Injuries
Therapeutic Actions : Laser Treatment: Low-Level
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Luteolin modulates the NF-E2-related factor 2/glutamate-cysteine ligase pathway in rats with spinal cord injury.Feb 28, 2021

Pubmed Data : J Med Food. 2021 Mar ;24(3):218-225. PMID: 33739882
Article Published Date : Feb 28, 2021
Study Type : Animal Study
Additional Links
Substances : Luteolin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Lycopene administration could improve total antioxidant status and might have neuroprotective effects on spinal cord injury.Mar 05, 2017

Pubmed Data : Neurosci Lett. 2017 Mar 6 ;642:107-112. Epub 2017 Feb 3. PMID: 28163080
Article Published Date : Mar 05, 2017
Study Type : Animal Study
Additional Links
Substances : Lycopene
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents
[+]

Lycopene exerted neuroprotective functions in Spinal cord ischemia/reperfusion injury and inhibited its elicited neuroinflammation via COX-2 suppression.Dec 31, 2018

Pubmed Data : Neuroimmunomodulation. 2019 ;26(2):84-92. Epub 2019 Jan 9. PMID: 30625493
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Lycopene
Diseases : Ischemia, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents
[+]

Melatonin has neuroprotective properties superior to methyprednisone in experimental spinal cord injury. Oct 01, 2005

Pubmed Data : Surg Neurol. 2005 Oct;64(4):355-61. PMID: 16231427
Article Published Date : Oct 01, 2005
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Lipid Peroxidation, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
Additional Keywords : Cortisone Alternatives, Superiority of Natural Substances versus Drugs
[+]

Melatonin improves functional recovery as effectively as methylpredisolone in experimental spinal cord injury. Dec 01, 2004

Pubmed Data : Eur Spine J. 2004 Dec;13(8):724-32. Epub 2004 Jul 1. PMID: 15232723
Article Published Date : Dec 01, 2004
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Additional Keywords : Cortisone Alternatives, Natural Substances Versus Drugs
[+]

Melatonin is superior to methylprednisolone in experimental spinal cord injury. Jul 01, 2000

Pubmed Data : J Neurosurg. 2000 Jul;93(1 Suppl):77-84. PMID: 10879762
Article Published Date : Jul 01, 2000
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Additional Keywords : Cortisone Alternatives, Drug: Methylprednisolone, Superiority of Natural Substances versus Drugs
[+]

Melatonin may be a promising therapeutic candidate for acute spinal cord injury.Dec 24, 2019

Pubmed Data : Neuropeptides. 2019 Dec 25:102002. Epub 2019 Dec 25. PMID: 31902595
Article Published Date : Dec 24, 2019
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Melatonin treatment alleviates spinal cord injury-induced gut dysbiosis in mice.Mar 27, 2019

Pubmed Data : J Neurotrauma. 2019 Mar 28. Epub 2019 Mar 28. PMID: 30693824
Article Published Date : Mar 27, 2019
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Dysbiosis, Spinal Cord Injuries
Pharmacological Actions : Gastrointestinal Agents
Additional Keywords : Risk Reduction
[+]

Mulberrin reduces spinal cord injury (SCI)-induced apoptosis, inflammation and oxidative stress.Oct 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Nov ;107:1480-1487. Epub 2018 Sep 4. PMID: 30257365
Article Published Date : Oct 31, 2018
Study Type : Animal Study
Additional Links
Substances : Mulberry
Diseases : Inflammation, Oxidative Stress, Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants
[+]

Myricitrin decreases traumatic injury of the spinal cord and exhibits antioxidant and anti‑inflammatory activities.Oct 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2017 Nov ;16(5):7699-7705. Epub 2017 Sep 21. PMID: 28944905
Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents, Transforming growth factor beta (TGF-β) inhibitor
[+]

Neuroprotective effect of asiatic acid against spinal cord injury in rats.Jul 14, 2016

Pubmed Data : Life Sci. 2016 Jul 15 ;157:45-51. Epub 2016 May 3. PMID: 27153777
Article Published Date : Jul 14, 2016
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Oxidative Stress, Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Neuroprotective effect of combining tanshinone IIA with low-dose methylprednisolone following acute spinal cord injury.Apr 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2017 May ;13(5):2193-2202. Epub 2017 Mar 28. PMID: 28565827
Article Published Date : Apr 30, 2017
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Neuroprotective effects and mechanism of saikosaponin A on acute spinal cord injury.Jan 14, 2017

Pubmed Data : Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2017 07 15 ;31(7):825-829. PMID: 29798527
Article Published Date : Jan 14, 2017
Study Type : Animal Study
Additional Links
Substances : Saikosaponin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Neuroprotective potential of Spirulina platensis on lesioned spinal cord corticospinal tract under experimental conditions.Dec 31, 2018

Pubmed Data : Ultrastruct Pathol. 2019 ;43(6):273-289. Epub 2019 Nov 28. PMID: 31779507
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Spirulina
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Nigella sativa treatment might be beneficial in spinal cord tissue damage.Feb 28, 2006

Pubmed Data : Hum Exp Toxicol. 2006 Mar ;25(3):127-33. PMID: 16634331
Article Published Date : Feb 28, 2006
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Lipid Peroxidation, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation
[+]

Notoginsenoside R1 alleviates spinal cord injury.Jun 27, 2022

Pubmed Data : Neuroreport. 2022 Jun 28 ;33(11). Epub 2022 Jun 28. PMID: 35776939
Article Published Date : Jun 27, 2022
Study Type : Animal Study
Additional Links
Substances : Ginsenosides, Panax Notoginseng
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Oleanolic acid inhibits mouse spinal cord injury through suppressing inflammation and apoptosis Feb 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 Mar ;123:109752. Epub 2020 Jan 8. PMID: 31924596
Article Published Date : Feb 29, 2020
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Paeoniflorin use may be a therapeutic strategy in spinal cord injury.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2018 ;2018:9865403. Epub 2018 Dec 2. PMID: 30627586
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Brain Inflammation , Inflammation, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

Paeonol regulates NLRP3 inflammasomes and pyroptosis to alleviate spinal cord injury.Mar 17, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Neurosci. 2022 Mar 18 ;23(1):16. Epub 2022 Mar 18. PMID: 35303801
Article Published Date : Mar 17, 2022
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Inflammation, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Panax notoginseng saponins improve recovery after spinal cord transection.Jul 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Regen Res. 2015 Aug ;10(8):1317-20. PMID: 26487862
Article Published Date : Jul 31, 2015
Study Type : Animal Study
Additional Links
Substances : Panax Notoginseng
Diseases : Spinal Cord Injuries
Pharmacological Actions : Brain-derived neurotrophic factor modulator, Neuroprotective Agents
Additional Keywords : Nerve Regeneration
[+]

Panax quinquefolius saponin is a novel therapeutic agent for acute central nervous system injury.May 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Jun ;102:212-220. Epub 2018 Mar 22. PMID: 29558718
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Ginseng (American)
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Pectolinarigenin promotes functional recovery and inhibits apoptosis in rats following spinal cord injuries.Apr 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2019 May ;17(5):3877-3882. Epub 2019 Mar 29. PMID: 31007732
Article Published Date : Apr 30, 2019
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Perillaldehyde alleviates spinal cord ischemia-reperfusion injury Via activating the Nrf2 pathway.Aug 12, 2021

Pubmed Data : J Surg Res. 2021 Aug 13 ;268:308-317. Epub 2021 Aug 13. PMID: 34399353
Article Published Date : Aug 12, 2021
Study Type : Animal Study
Additional Links
Substances : Perillaldehyde
Diseases : Spinal Cord Injuries
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Polyphenolic grape stalk and coffee extracts attenuate spinal cord injury-induced neuropathic pain.Sep 01, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2022 Sep 2 ;12(1):14980. Epub 2022 Sep 2. PMID: 36056079
Article Published Date : Sep 01, 2022
Study Type : Animal Study
Additional Links
Substances : Coffee, Grape
Diseases : Hyperalgesia, Neuropathic Pain, Spinal Cord Injuries
Pharmacological Actions : Analgesics
[+]

Postinjury treatment with magnesium sulfate attenuates neuropathic pains following spinal cord injury in male rats.Mar 31, 2015

Pubmed Data : Behav Pharmacol. 2015 Apr ;26(3):315-20. PMID: 25369748
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Magnesium Sulfate
Diseases : Hyperalgesia, Neuropathic Pain, Spinal Cord Injuries
Pharmacological Actions : Analgesics
[+]

Progesterone demonstrates neuroprotective and promyelinating effects in lesions of the peripheral and central nervous system.Jan 01, 2006

Pubmed Data : J Mol Neurosci. 2006;28(1):3-15. PMID: 16632872
Article Published Date : Jan 01, 2006
Study Type : Animal Study
Additional Links
Substances : Progesterone
Diseases : Demyelinating Diseases, Spinal Cord Injuries
[+]

Protective effect of lutein on spinal cord ischemia-reperfusion injury in rats.Mar 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2019 Apr ;22(4):412-417. PMID: 31168346
Article Published Date : Mar 31, 2019
Study Type : Animal Study
Additional Links
Substances : Lutein
Diseases : Ischemia, Spinal Cord Injuries
Pharmacological Actions : Antioxidants
[+]

Protective effect of nicotinamide adenine dinucleotide (NAD+) against spinal cord ischemia-reperfusion injury.Jan 31, 2017

Pubmed Data : J Clin Neurosci. 2017 Feb ;36:114-119. Epub 2016 Nov 23. PMID: 27887979
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Substances : Nicotinamide adenine dinucleotide (NADH)
Diseases : Ischemia, Oxidative Stress, Spinal Cord Injuries
Pharmacological Actions : Antioxidants, Apoptotic, Neuroprotective Agents
[+]

Protective effect of puerarin on the secondary spinal cord injury in ratsFeb 28, 2009

Pubmed Data : Zhong Yao Cai. 2009 Mar ;32(3):395-7. PMID: 19565720
Article Published Date : Feb 28, 2009
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
[+]

Puerarin accelerated locomotor function recovery and tissue repair of SCI rats.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2016 ;39(3):1152-64. Epub 2016 Aug 31. PMID: 27576607
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Puerarin can significantly ameliorate the neural function and the histopathological damages after transient spinal cord ischemia in rabbits.May 31, 2004

Pubmed Data : Chin J Traumatol. 2004 Jun ;7(3):143-7. PMID: 15294110
Article Published Date : May 31, 2004
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Ischemia, Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Quercetin reduces neural tissue damage and promotes astrocyte activation after spinal cord injury in rats.Sep 01, 2017

Pubmed Data : J Cell Biochem. 2017 Sep 2. Epub 2017 Sep 2. PMID: 28865131
Article Published Date : Sep 01, 2017
Study Type : Animal Study
Additional Links
Substances : Quercetin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Red-light (670 nm) therapy reduces mechanical sensitivity and neuronal cell death, and alters glial responses after spinal cord injury.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neurotrauma. 2020 11 1 ;37(21):2244-2260. Epub 2020 Aug 10. PMID: 32552352
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Diseases : Hyperalgesia, Spinal Cord Injuries
Therapeutic Actions : Light Therapy: Red Colored
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Repeated administration of naringenin may provide protection against spinal cord injury.Jul 14, 2016

Pubmed Data : Gene. 2016 Jul 15. Epub 2016 Jul 15. PMID: 27432064
Article Published Date : Jul 14, 2016
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Neutrophils: Elevated, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator
[+]

Repetitive application of diluted bee venom acupuncture therapy suppressed SCI induced central neuropathic pain syndrome development.Jun 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxins (Basel). 2015 Jul ;7(7):2571-85. Epub 2015 Jul 10. PMID: 26184310
Article Published Date : Jun 30, 2015
Study Type : Animal Study
Additional Links
Substances : Bee Venom
Diseases : Neuropathic Pain, Spinal Cord Injuries
Therapeutic Actions : Acupuncture
[+]

Resveratrol exerts neuroprotective effects on spinal cord injury by regulating autophagy and apoptosis.Feb 22, 2017

Pubmed Data : Neuroscience. 2017 Feb 23. Epub 2017 Feb 23. PMID: 28238848
Article Published Date : Feb 22, 2017
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Neuroprotective Agents, RESVERATROL, Spinal Cord Injuries
[+]

Resveratrol exhibits superior efficacy versus methylprednisolone, and enhances efficacy in combination, for recovery after experimental spinal cord injury. Oct 01, 2006

Pubmed Data : Acta Pharmacol Sin. 2006 Oct;27(10):1317-25. PMID: 17007738
Article Published Date : Oct 01, 2006
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Drug-Plant-Vitamin Synergies, Stilbenes, Superiority of Natural Substances versus Drugs
[+]

Resveratrol improves neuron protection and functional recovery in rat model of spinal cord injury.Feb 16, 2011

Pubmed Data : Brain Res. 2011 Feb 16;1374:100-9. Epub 2010 Nov 25. PMID: 21111721
Article Published Date : Feb 16, 2011
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents, Neurorestorative
[+]

Resveratrol inhibits inflammation after spinal cord injury.Jan 24, 2021

Pubmed Data : Neurosci Lett. 2021 09 25 ;762:136151. Epub 2021 Aug 2. PMID: 34352338
Article Published Date : Jan 24, 2021
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Resveratrol suppresses microglial activation and promotes functional recovery of traumatic spinal cord via improving intestinal microbiota.Jul 31, 2022

Pubmed Data : Pharmacol Res. 2022 Aug 1 ;183:106377. Epub 2022 Aug 1. PMID: 35926806
Article Published Date : Jul 31, 2022
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents
[+]

Salvia miltiorrhiza extract attenuates spinal cord injury.May 20, 2019

Pubmed Data : Phytomedicine. 2019 May 21 ;62:152966. Epub 2019 May 21. PMID: 31132751
Article Published Date : May 20, 2019
Study Type : Animal Study
Additional Links
Substances : Salvia miltiorrhiza
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Selenium-enriched supplement have a protective role in spinal cord injury.Oct 31, 2015

Pubmed Data : Eur Rev Med Pharmacol Sci. 2015 Nov ;19(22):4434-42. PMID: 26636534
Article Published Date : Oct 31, 2015
Study Type : Animal Study
Additional Links
Substances : Selenium
Diseases : Spinal Cord Injuries
Pharmacological Actions : MicroRNA modulator
[+]

Sesamol attenuates aeuroinflammation by regulating the AMPK/SIRT1/NF- κB signaling pathway after spinal cord injury.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:8010670. Epub 2022 Jan 6. PMID: 35035666
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Brain Inflammation , Spinal Cord Injuries
Pharmacological Actions : Antioxidants, NF-kappaB Inhibitor
[+]

Shikonin induced the recovery of tissue repair and motor function after spinal cord injury.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2017 ;43(2):481-491. Epub 2017 Sep 20. PMID: 28934735
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Shikonin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Sinomenine attenuates traumatic spinal cord injury.Mar 31, 2019

Pubmed Data : Neurochem Res. 2019 Apr ;44(4):763-775. Epub 2019 Jan 2. PMID: 30603983
Article Published Date : Mar 31, 2019
Study Type : Animal Study
Additional Links
Substances : Sinomenine
Diseases : Inflammation, Oxidative Stress, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Statins decrease chondroitin sulfate proteoglycan expression following central nervous system injury. Nov 01, 2008

Pubmed Data : Exp Neurol. 2008 Nov ;214(1):78-86. Epub 2008 Aug 5. PMID: 18722369
Article Published Date : Nov 01, 2008
Study Type : Animal Study
Additional Links
Diseases : Proteoglycan Expression: Down-Regulation of Chondroitin Sulfate, Proteoglycan Expression: Pathological, Spinal Cord Injuries, Statin-Induced Pathologies
Problem Substances : Simvastatin, Statin Drugs
[+]

Sulforaphane reduces inflammation following spinal cord injury in mice.Jan 01, 2010

Pubmed Data : Ann Clin Lab Sci. 2010;40(4):354-60. PMID: 20947810
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-9 (MMP-9) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Synergistic effect of ascorbic acid and taurine in the treatment of a spinal cord injury-induced model in rats.Jan 31, 2020

Pubmed Data : 3 Biotech. 2020 Feb ;10(2):50. Epub 2020 Jan 16. PMID: 32002341
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Taurine, Vitamin C
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Natural Substance Synergy
[+]

Synergistic neuroprotective effects of hyperbaric oxygen and N-acetylcysteine against traumatic spinal cord injury in rat.Sep 29, 2021

Pubmed Data : J Chem Neuroanat. 2021 Sep 30 ;118:102037. Epub 2021 Sep 30. PMID: 34601074
Article Published Date : Sep 29, 2021
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Spinal Cord Injuries
Therapeutic Actions : Hyperbaric Treatment
Pharmacological Actions : Neuroprotective Agents
[+]

Tanshinone IIA alleviates oxidative damage after spinal cord injury in vitro and in vivo.Dec 31, 2018

Pubmed Data : Life Sci. 2019 Jan 1 ;216:147-155. Epub 2018 Nov 22. PMID: 30468834
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Oxidative Stress, Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Antioxidants, MicroRNA modulator
[+]

Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response.Oct 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2019 Nov ;18(5):3681-3687. Epub 2019 Sep 5. PMID: 31602247
Article Published Date : Oct 31, 2019
Study Type : Animal Study
Additional Links
Substances : Tetrahydrocurcumin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor
[+]

Tetramethylpyrazine alleviates neural apoptosis in injured spinal cord.Sep 30, 2017

Pubmed Data : Biomed Pharmacother. 2017 Oct ;94:827-833. Epub 2017 Aug 10. PMID: 28802236
Article Published Date : Sep 30, 2017
Study Type : Animal Study
Additional Links
Substances : Ligustrazine
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, MicroRNA modulator, Neuroprotective Agents
[+]

The neuroprotective role of morroniside against spinal cord injury.Dec 31, 2020

Pubmed Data : Neurochem Int. 2021 09 ;148:105105. Epub 2021 Jun 17. PMID: 34147513
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Dogwood
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

The present study demonstrated that administration of puerarin reduced the spinal ischemia/reperfusion injury.May 23, 2013

Pubmed Data : Neurosci Lett. 2013 May 24 ;543:64-8. Epub 2013 Apr 6. PMID: 23570727
Article Published Date : May 23, 2013
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

The present study suggests that the role of electroacupuncture in neuroprotection and dorsal neuronal function recovery after SCI in rats.Dec 31, 2015

Pubmed Data : Neural Plast. 2016 ;2016:2371875. Epub 2016 Aug 11. PMID: 27597902
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Diseases : Spinal Cord Injuries
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Neuroprotective Agents
[+]

The protective mechanism of action of plantamajoside on a rat model of acute spinal cord injury.Mar 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2021 Apr ;21(4):378. Epub 2021 Feb 19. PMID: 33680100
Article Published Date : Mar 31, 2021
Study Type : Animal Study
Additional Links
Substances : Plantago
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

The results of the present study may, therefore, be useful in improving the clinical application of HBO therapy for patients with SCI.Nov 30, 2016

Pubmed Data : Mol Med Rep. 2016 Dec ;14(6):5619-5625. Epub 2016 Nov 9. PMID: 27840972
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Diseases : Spinal Cord Injuries
Therapeutic Actions : Hyperbaric Treatment
[+]

The use of asiatic acid may be a potential efficient therapeutic strategy for the treatment of spinal cord injury-induced acute lung injury.Nov 30, 2016

Pubmed Data : Inflammation. 2016 Dec ;39(6):1853-1861. PMID: 27605220
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Inflammation, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Nrf2 activation
[+]

These findings suggested that tanshinone IIA improved functional recovery after spinal cord injury-induced lower urinary tract dysfunction.Jan 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Regen Res. 2017 Feb ;12(2):267-275. PMID: 28400810
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Natural Substances Versus Drugs
[+]

These results suggest that electro-acupuncture therapy may promote spinal cord recovery following injury.Jun 18, 2017

Pubmed Data : Mol Med Rep. 2017 Jun 19. Epub 2017 Jun 19. PMID: 28627669
Article Published Date : Jun 18, 2017
Study Type : Animal Study
Additional Links
Diseases : Spinal Cord Injuries
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Wnt/β-catenin signaling pathway modulation
[+]

These results suggest that ginsenoside Rg3 may be a potential therapeutic agent for the treatment of spinal cord injury.Jan 11, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2017 Jan 12 ;22(1). Epub 2017 Jan 12. PMID: 28085110
Article Published Date : Jan 11, 2017
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents
[+]

These results suggest that the anti-inflammatory effect of delphinidin alleviated inflammation in a spinal cord injury model.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2017 Dec ;14(6):5583-5588. Epub 2017 Sep 27. PMID: 29285096
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Delphinidin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation
[+]

This study confirmed the therapeutic efficacy of apocynin in the repair of spinal cord Injuries.Feb 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2017 Mar ;13(3):952-960. Epub 2017 Jan 25. PMID: 28450925
Article Published Date : Feb 28, 2017
Study Type : Animal Study
Additional Links
Substances : Apocynin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

This study provided an encouraging novel strategy for the potential treatment of spinal cord injury patients with beta-elemene.Jul 14, 2018

Pubmed Data : Neuroscience. 2018 Jul 15 ;383:12-21. Epub 2018 May 9. PMID: 29751054
Article Published Date : Jul 14, 2018
Study Type : Animal Study
Additional Links
Substances : Beta-Elemene
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuritogenic
[+]

This study shows the potential beneficial effects of DHA combined with rehabilitation for the treatment of patients with SCI.Nov 22, 2016

Pubmed Data : J Neurotrauma. 2016 Nov 23. Epub 2016 Nov 23. PMID: 27881040
Article Published Date : Nov 22, 2016
Study Type : Animal Study
Additional Links
Substances : DHA (Docosahexaenoic Acid)
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroplasticity enhancement
[+]

Thymoquinone exhibits an important protective effect against ischemia-reperfusion injury of the spinal cord.Feb 11, 2016

Pubmed Data : J Neurosurg Spine. 2016 Feb 12:1-11. Epub 2016 Feb 12. PMID: 26871652
Article Published Date : Feb 11, 2016
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Ischemia, Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Thymoquinone reduces spinal cord injury by inhibiting inflammatory response, oxidative stress and apoptosis May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2018 Jun ;15(6):4987-4994. Epub 2018 Apr 16. PMID: 29904397
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Total flavonoids of hawthorn leaves protect spinal motor neurons.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:925568. Epub 2022 Aug 22. PMID: 36071834
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Hawthorn
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Treatment with curcumin alleviates sublesional bone loss following spinal cord injury in rats.Aug 19, 2015

Pubmed Data : Eur J Pharmacol. 2015 Aug 20 ;765:209-216. Epub 2015 Aug 20. PMID: 26300394
Article Published Date : Aug 19, 2015
Study Type : Animal Study
Additional Links
Diseases : Spinal Cord Injuries
Pharmacological Actions : MicroRNA modulator, NF-kappaB Inhibitor, Wnt/β-catenin signaling pathway modulation
[+]

Ultraviolet blood irradiation and oxygenation affects free radicals and antioxidase after rabbit spinal cord injury.Oct 31, 2000

Pubmed Data : Chin Med J (Engl). 2000 Nov ;113(11):991-5. PMID: 11776133
Article Published Date : Oct 31, 2000
Study Type : Animal Study
Additional Links
Diseases : Spinal Cord Injuries
Therapeutic Actions : Light Therapy, Oxygen Therapy
Pharmacological Actions : Antioxidants, Superoxide Dismutase Up-regulation
Additional Keywords : Ultraviolet Blood Irradiation
[+]

Ursolic acid ameliorates spinal cord injury in mice by regulating gut microbiota.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cell Neurosci. 2022 ;16:872935. Epub 2022 May 4. PMID: 35602557
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Ursolic Acid
Diseases : Spinal Cord Injuries
Pharmacological Actions : Gastrointestinal Agents
[+]

Ursolic acid treatment may be a potential therapeutic strategy to improve muscle-specific pathological consequences of spinal cord injury.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2018 ;13(8):e0203042. Epub 2018 Aug 29. PMID: 30157245
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Ursolic Acid
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neurogenesis
[+]

Vanillin ameliorates changes in HIF-1α expression and neuronal apoptosis in a rat model of spinal cord injury.Feb 03, 2019

Pubmed Data : Restor Neurol Neurosci. 2019 Feb 4. Epub 2019 Feb 4. PMID: 30741707
Article Published Date : Feb 03, 2019
Study Type : Animal Study
Additional Links
Substances : Vanillin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Neuroprotective Agents
[+]

Vitamin C has protective effects against spinal cord injury-induced kidney damage.Mar 31, 2015

Pubmed Data : Neurol Sci. 2015 Apr ;36(4):521-6. Epub 2014 Nov 18. PMID: 25403314
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Wild bitter melon exerts anti-inflammatory effects by upregulating injury-attenuated CISD2 expression following spinal cord injury.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Behav Neurol. 2020 ;2020:1080521. Epub 2020 Sep 30. PMID: 33062068
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Bitter Melon
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Zinc has a protective effect on spinal cord injury by inhibiting oxidative damage and nlrp3 inflammation.Jan 21, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Life Sci. 2020 Jan 22:117351. Epub 2020 Jan 22. PMID: 31981629
Article Published Date : Jan 21, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Zinc
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

A review of hyperbaric oxygen therapy for spinal cord ischaemia after complex aortic repair.Jun 07, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anaesthesiol Intensive Ther. 2018 Jun 8. Epub 2018 Jun 8. PMID: 29882580
Article Published Date : Jun 07, 2018
Study Type : Review
Additional Links
Diseases : Ischemia, Spinal Cord Injuries
Therapeutic Actions : Hyperbaric Treatment
[+]

Angelica polysaccharide protects PC-12 cells from lipopolysaccharide-induced injury via down-regulating microRNA-223.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2018 Dec ;108:1320-1327. Epub 2018 Oct 4. PMID: 30372834
Article Published Date : Nov 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Angelica
Diseases : Lipopolysaccharide-Induced Toxicity, Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, MicroRNA modulator, NF-kappaB Inhibitor
[+]

Berberine loaded chitosan nanoparticles encapsulated in polysaccharide-based hydrogel for the repair of spinal cord.Mar 21, 2021

Pubmed Data : Int J Biol Macromol. 2021 Mar 22. Epub 2021 Mar 22. PMID: 33766598
Article Published Date : Mar 21, 2021
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents, Regenerative
Additional Keywords : Nerve Regeneration
[+]

Betulinic acid inhibits pyroptosis in spinal cord injury.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Biol Sci. 2021 ;17(4):1138-1152. Epub 2021 Mar 11. PMID: 33867836
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Butylphthalide has an anti-Inflammatory role in spinal cord injury.Aug 31, 2020

Pubmed Data : Spine (Phila Pa 1976). 2020 Sep 1 ;45(17):E1066-E1076. PMID: 32205688
Article Published Date : Aug 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Celery Oil
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Cannabigerol pre-treatment can modulate oxidative stress and increase antioxidant enzyme gene.Jan 18, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2022 Jan 19 ;15(2). Epub 2022 Jan 19. PMID: 35215230
Article Published Date : Jan 18, 2022
Study Type : In Vitro Study
Additional Links
Substances : Cannabigerol
Diseases : Spinal Cord Injuries
Pharmacological Actions : Antioxidants, Regenerative
Additional Keywords : Gene Expression Regulation, Nerve Regeneration
[+]

Coenzyme Q10 may be considered as a potential effective therapeutic for the treatment of spinal cord injury.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2019 ;11(10):6544-6552. Epub 2019 Oct 15. PMID: 31737205
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Coenzyme Q10
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Coenzyme Q10 regulates apoptosis and oxidative stress in hydrogen peroxide induced bone marrow mesenchymal stem cell death.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:6493081. Epub 2019 Dec 12. PMID: 31915512
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Coenzyme Q10
Diseases : Glucosephosphate Dehydrogenase Deficiency, Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents, Nrf2 activation
Additional Keywords : Mesenchymal Stem Cells
[+]

Curcumin could be of therapeutic use in the treatment of spinal cord injury.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neurol Res Int. 2016 ;2016:9468193. Epub 2016 May 19. PMID: 27298735
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Curcumin stimulates cell viability in olfactory ensheathing cells grown in normal and hypoxic conditions.Nov 22, 2016

Pubmed Data : Eur J Pharmacol. 2016 Nov 23. Epub 2016 Nov 23. PMID: 27889433
Article Published Date : Nov 22, 2016
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Hypoxia, Spinal Cord Injuries
[+]

Daidzein may have therapeutic value in the treatment of spinal cord injury, optic nerve injury and/or stroke. Jan 13, 2010

Pubmed Data : J Neurosci. 2010 Jan 13;30(2):739-48. PMID: 20071539
Article Published Date : Jan 13, 2010
Study Type : In Vitro Study
Additional Links
Substances : Daidzein, Isoflavones
Diseases : Optic Nerve Diseases, Spinal Cord Injuries, Stroke
Pharmacological Actions : Arginase 1 (Arg1) up-regulation, Enzyme Inhibitors, Neuroprotective Agents
[+]

Electro-acupuncture inhibits p66Shc-mediated oxidative stress to facilitate functional recovery after spinal cord injury.Jun 01, 2020

Pubmed Data : J Mol Neurosci. 2020 Jun 2. Epub 2020 Jun 2. PMID: 32488847
Article Published Date : Jun 01, 2020
Study Type : In Vitro Study
Additional Links
Diseases : Spinal Cord Injuries
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Antioxidants
[+]

Epigallocatechin-3-gallate (EGCG) prevents the antineuritogenic activity of Nogo-A, a myelin-derived axonal growth inhibitor.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neurochem. 2015 Jan ;132(1):70-84. PMID: 25314656
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Spinal Cord Injuries, Stroke: Attenuation/Recovery
Pharmacological Actions : Neuritogenic, Neuroprotective Agents
[+]

Estrogen may have therapeutic value in the treatment of amyotrophic lateral sclerosis and spinal cord injury.Feb 01, 2011

Pubmed Data : J Endocrinol. 2011 Feb;208(2):171-82. Epub 2010 Nov 10. PMID: 21068071
Article Published Date : Feb 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Estradiol (E(2))
Diseases : Amyotrophic Lateral Sclerosis, Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Gensenoside Rg1 promotes proliferation and neurotrophin expression fo olfactory ensheathing cells, which participate in neurological repair. Apr 01, 2010

Pubmed Data : J Asian Nat Prod Res. 2010 Apr;12(4):265-72. PMID: 20419536
Article Published Date : Apr 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Demyelinating Diseases, Spinal Cord Injuries
Pharmacological Actions : Neuritogenic, Neuroprotective Agents
[+]

Ginsenoside Rb1 attenuates microglia activation to improve spinal cord injury.Aug 05, 2020

Pubmed Data : J Cell Physiol. 2020 Aug 6. Epub 2020 Aug 6. PMID: 32761843
Article Published Date : Aug 05, 2020
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator, NF-kappaB Inhibitor
[+]

Goji berry polysaccharide is a promising neuronal protector with potent ameliorative effects on key pathological events.Mar 30, 2016

Pubmed Data : Neuromolecular Med. 2016 Mar 31. Epub 2016 Mar 31. PMID: 27033360
Article Published Date : Mar 30, 2016
Study Type : Review
Additional Links
Substances : Goji
Diseases : Alzheimer's Disease, Brain: Oxidative Stress, Brain Inflammation , Parkinson's Disease, Spinal Cord Injuries, Stroke: Attenuation/Recovery
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Green tea polyphenols play a protective role in spinal cord neurons under oxidative stress.Jul 14, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Regen Res. 2014 Jul 15 ;9(14):1379-85. PMID: 25221595
Article Published Date : Jul 14, 2014
Study Type : In Vitro Study
Additional Links
Substances : Green Tea
Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress, Spinal Cord Injuries
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents
Additional Keywords : Nerve Regeneration
[+]

Icariin promotes the repair of PC12 cells by inhibiting endoplasmic reticulum stress.Feb 18, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Med Ther. 2021 Feb 19 ;21(1):69. Epub 2021 Feb 19. PMID: 33607999
Article Published Date : Feb 18, 2021
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Inhibition of autophagy is involved in the neuroprotective effects of Ginsenoside Rb1 on spinal cord injury.Jul 30, 2017

Pubmed Data : Cell Mol Neurobiol. 2017 Jul 31. Epub 2017 Jul 31. PMID: 28762191
Article Published Date : Jul 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Spinal Cord Injuries
Pharmacological Actions : Autophagy Inhibitors, Neuroprotective Agents
Additional Keywords : Autophagy Inhibitors, Ginsenosides, Neuroprotective Agents, Spinal Cord Injuries
[+]

Intermittent fasting and the ketogenic diet may promote neuroprotection and facilitate the regeneration and repair of nerve fibers following injury.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2021 ;16(1):e0244244. Epub 2021 Jan 4. PMID: 33395427
Article Published Date : Dec 31, 2020
Study Type : Review
Additional Links
Diseases : Spinal Cord Injuries
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Nerve Regeneration
[+]

Isorhamnetin promotes functional recovery in rats with spinal cord injury.Mar 14, 2021

Pubmed Data : Eur J Pharmacol. 2021 Mar 15 ;895:173878. Epub 2021 Jan 14. PMID: 33453223
Article Published Date : Mar 14, 2021
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Mechanisms of ginsenosides exert neuroprotective effects on spinal cord injury.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurosci. 2022 ;16:969056. Epub 2022 Aug 23. PMID: 36081662
Article Published Date : Dec 31, 2021
Study Type : Review
Additional Links
Substances : Ginsenosides
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Neuroprotective mechanisms of ginsenoside Rb1 in central nervous system diseases. Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:914352. Epub 2022 Jun 2. PMID: 35721176
Article Published Date : Dec 31, 2021
Study Type : Review
Additional Links
Substances : Ginsenosides
Diseases : Central Nervous System Diseases, Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Autophagy Inhibitors, Neuroprotective Agents
[+]

Neuroprotective mechanisms of puerarin in central nervous system diseases.Jul 10, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Aging Dis. 2022 Jul 11 ;13(4):1092-1105. Epub 2022 Jul 11. PMID: 35855345
Article Published Date : Jul 10, 2022
Study Type : Review
Additional Links
Substances : Puerarin
Diseases : Alzheimer's Disease, Central Nervous System Diseases, Cerebral Ischemia, Depression, Parkinson's Disease, Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Neuroprotective potential of fisetin in an experimental model of spinal cord injury.Jan 17, 2021

Pubmed Data : Neuroreport. 2021 Jan 18. Epub 2021 Jan 18. PMID: 33470764
Article Published Date : Jan 17, 2021
Study Type : In Vitro Study
Additional Links
Substances : Fisetin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Parthenolide promotes the repair of spinal cord injury.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Discov. 2020 ;6:97. Epub 2020 Oct 6. PMID: 33083018
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Parthenolide
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Nerve Regeneration
[+]

Patchouli alcohol exerts neuroprotective effects by maintaining BSCB integrity and thus be a promising candidate for spinal cord injury treatment.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cell Dev Biol. 2021 ;9:693533. Epub 2021 Jul 22. PMID: 34368142
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Patchouli
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents
[+]

Progesterone has neuroprotective properties in traumatic central nervous system and motor neuron degeneration.Jul 01, 2009

Pubmed Data : Front Neuroendocrinol. 2009 Jul;30(2):173-87. Epub 2009 Mar 24. PMID: 19318112
Article Published Date : Jul 01, 2009
Study Type : Review
Additional Links
Substances : Progesterone
Diseases : Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Motor Neuron Disease: Amyotrophic Lateral Sclerosis, Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Pterostilbene inhibits reactive oxygen species production and apoptosis in primary spinal cord neurons.Jan 08, 2018

Pubmed Data : Mol Med Rep. 2018 Jan 9. Epub 2018 Jan 9. PMID: 29328494
Article Published Date : Jan 08, 2018
Study Type : In Vitro Study
Additional Links
Substances : Pterostilbene
Diseases : Hydrogen Peroxide Induced Toxicity, Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Autophagy Up-regulation, Neuroprotective Agents
[+]

Resveratrol can attenuate astrocyte activation to treat spinal cord injury. Aug 18, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Neurobiol. 2021 Aug 19. Epub 2021 Aug 19. PMID: 34410605
Article Published Date : Aug 18, 2021
Study Type : Review
Additional Links
Substances : Resveratrol
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Rosmarinic acid exerts a neuroprotective effect on spinal cord injury.Apr 18, 2020

Pubmed Data : Toxicol Appl Pharmacol. 2020 Apr 19 ;397:115014. Epub 2020 Apr 19. PMID: 32320792
Article Published Date : Apr 18, 2020
Study Type : In Vitro Study
Additional Links
Substances : Rosemaric Acid
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Rutin was demonstrated as a potential protective agent in spinal cord injury.Oct 31, 2015

Pubmed Data : Mol Med Rep. 2015 Nov ;12(5):7554-60. PMID: 26502930
Article Published Date : Oct 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Rutin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Sesamol loaded nanomicelles can be developed as a promising platform for the mitigation of oxidative stress-mediated apoptosis in neural cells.Jun 28, 2021

Pubmed Data : Int J Biol Macromol. 2021 Jun 29 ;186:23-32. Epub 2021 Jun 29. PMID: 34214577
Article Published Date : Jun 28, 2021
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents, NF-kappaB Inhibitor
[+]

The endocannabinoid system and its modulation by cannabidiol.May 31, 2019

Pubmed Data : Altern Ther Health Med. 2019 Jun ;25(S2):6-14. PMID: 31202198
Article Published Date : May 31, 2019
Study Type : Review
Additional Links
Substances : Cannabidiol
Diseases : Autoimmune Diseases, Cancers: All, Osteoporosis, Spinal Cord Injuries, Stroke
Additional Keywords : Endocannabinoid System
[+]

The mechanism of Naringin-enhanced remyelination after spinal cord injury.Feb 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Regen Res. 2017 Mar ;12(3):470-477. PMID: 28469664
Article Published Date : Feb 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Spinal Cord Injuries
Additional Keywords : Nerve Regeneration
[+]

This review discusses the neuroprotective potential of resveratrol in stroke, traumatic brain injury and spinal cord injury.Aug 11, 2015

Pubmed Data : Neurochem Int. 2015 Aug 12. Epub 2015 Aug 12. PMID: 26277384
Article Published Date : Aug 11, 2015
Study Type : Review
Additional Links
Substances : Resveratrol
Diseases : Spinal Cord Injuries, Stroke: Attenuation/Recovery , Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
[+]

This review provides an overview of current knowledge of palmitoylethanolamide effect on glial functions in the brain.Jan 31, 2013

Pubmed Data : CNS Neurol Disord Drug Targets. 2013 Feb 1 ;12(1):55-61. PMID: 23394520
Article Published Date : Jan 31, 2013
Study Type : Review
Additional Links
Substances : Palmitoylethanolamide
Diseases : Neurodegenerative Diseases, Neuropathic Pain, Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Urolithin A is a potential candidate for the treatment of spinal cord injuries.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:9090113. Epub 2022 Apr 22. PMID: 35497925
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Wogonin inhibits inflammation and apoptosis through STAT3 signal pathway to promote the recovery of spinal cord injury.Feb 20, 2022

Pubmed Data : Brain Res. 2022 Feb 21:147843. Epub 2022 Feb 21. PMID: 35202619
Article Published Date : Feb 20, 2022
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents
[+]

Ashwaganda shows great promise in the treatment of neurodegenerative illnesses such as dementia and spinal cord injury.Aug 01, 2008

Pubmed Data : Yakugaku Zasshi. 2008 Aug;128(8):1159-67. PMID: 18670181
Article Published Date : Aug 01, 2008
Additional Links
Diseases : Spinal Cord Injuries

Copyright: pixologic / 123RF Stock Photo

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