Spinal Cord Injuries

Name	AC	CK
Curcumin	9	24
Cannabidiol	4	15
Caffeic acid phenethyl ester	2	12
Coenzyme Q10	2	12
DHA (Docosahexaenoic Acid)	2	12
Ginsenosides	7	12
Selenium	2	12
Cannabis	1	10
Chlorella (Algae)	1	10
Creatine	1	10
Delta-tetrahydrocannabinol (THC)	1	10
EPA (Eicosapentaenoic Acid)	1	10
Honey	1	10
Marijuana	1	10
Vitamin B-12	1	10
Vitamin D	1	10
Vitamin E	1	10
Whey	1	10
Puerarin	4	8
Resveratrol	4	7
Astaxanthin	3	6
Melatonin	3	6
Tanshinone IIA	3	6
Asiatic Acid	2	4
Bee Venom	2	4
Beta-Elemene	2	4
Geraniol	2	4
Sulforaphane	2	4
Thymoquinone	2	4
Ayurvedic Formulations	1	3
Daidzein	2	3
Palmitoylethanolamide	2	3
Progesterone	2	3
Allicin	1	2
Alpha-Lipoic Acid	1	2
Apocynin	1	2
Arginine	1	2
Carnosol	1	2
Catechin	1	2
Chinese Skullcap	1	2
Chlorogenic Acid	1	2
Crocetin	1	2
Delphinidin	1	2
Garlic: Aged	1	2
Gastrodin	1	2
Ginseng (American)	1	2
Huperzine	1	2
Licorice	1	2
Ligustrazine	1	2
Luteolin	1	2
Lycopene	1	2
Magnesium	1	2
Magnesium Sulfate	1	2
Naringenin	1	2
Nicotinamide adenine dinucleotide (NADH)	1	2
Nigella sativa (aka Black Seed)	1	2
Paeoniflorin	1	2
Panax Notoginseng	1	2
Quercetin	1	2
Salvia miltiorrhiza	1	2
Shikonin	1	2
Vanillin	1	2
Vitamin C	1	2
Citrus naringin	1	1
EGCG (Epigallocatechin gallate)	1	1
Estradiol (E(2))	1	1
Goji	1	1
Green Tea	1	1
Isoflavones	1	1
Pterostilbene	1	1
Rutin	1	1

Name	AC	CK	Focus
Simvastatin	1	2
Statin Drugs	1	2

Name	AC	CK
Hyperbaric Treatment	5	18
Acupuncture	3	14
Yoga	1	10
Electroacupuncture	4	8
Dietary Modification: Low Carbohydrate/Ketogenic	1	2
Laser Treatment: Low-Level	1	2

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Administration of vitamin C and vitamin E in animal models of spinal cord injury significantly improves the recovery of motor function.Dec 03, 2019

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Pubmed Data : Nutr Rev. 2019 Dec 4. Epub 2019 Dec 4. PMID: 31800057

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Pubmed Data : J Neuroinflammation. 2015 ;12(1):204. Epub 2015 Nov 6. PMID: 26545369

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Pubmed Data : J Pain Res. 2017 ;10:999-1017. Epub 2017 May 3. PMID: 28496356

Article Published Date : Dec 31, 2016

Study Type : Human Study

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Diseases : Depression, Spinal Cord Injuries

Therapeutic Actions : Yoga

Pharmacological Actions : Antidepressive Agents

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Acupunct Meridian Stud. 2017 Jun ;10(3):204-210. Epub 2017 Apr 21. PMID: 28712480

Article Published Date : May 31, 2017

Study Type : Animal Study

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Substances : Bee Venom

Diseases : Spinal Cord Injuries

Therapeutic Actions : Acupuncture

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation

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Berberine-loaded M2 macrophage-derived exosomes for spinal cord injury therapy.Mar 11, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Acta Biomater. 2021 Mar 12. Epub 2021 Mar 12. PMID: 33722788

Article Published Date : Mar 11, 2021

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Spinal Cord Injuries

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Exosomes

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Beta-elemene reduces neuronal apoptosis by alleviating endoplasmic reticulum stress in vitro and in vivo.Dec 31, 2017

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Pubmed Data : Front Pharmacol. 2016 ;7:47. Epub 2016 Mar 8. PMID: 27014061

Daidzein ameliorates spinal cord ischemia/reperfusion injury-induced neurological function deficits.Oct 31, 2017

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Pubmed Data : Zhen Ci Yan Jiu. 2019 Nov 25 ;44(11):781-6. PMID: 31777225

Article Published Date : Nov 24, 2019

Study Type : Animal Study

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Diseases : Inflammation, Oxidative Stress, Spinal Cord Injuries

Therapeutic Actions : Electroacupuncture

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Nrf2 activation

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Electroacupuncture promoted axonal regeneration in spinal cord injury.Dec 31, 2018

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Pubmed Data : Neuropsychiatr Dis Treat. 2019 ;15:3429-3442. Epub 2019 Dec 13. PMID: 31997879

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Diseases : Spinal Cord Injuries

Therapeutic Actions : Electroacupuncture

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Nerve Regeneration

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Epicatechin reduces muscle waste after complete spinal cord transection.Nov 04, 2020

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Pubmed Data : Mol Biol Rep. 2020 Nov 5. Epub 2020 Nov 5. PMID: 33151476

Article Published Date : Nov 04, 2020

Study Type : Animal Study

Additional Links

Substances : Epicatechin

Diseases : Muscle Atrophy , Spinal Cord Injuries

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Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation.Apr 30, 2010

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Pubmed Data : J Clin Invest. 2010 May ;120(5):1603-16. Epub 2010 Apr 26. PMID: 20424322

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Pubmed Data : Biol Pharm Bull. 2017 ;40(10):1630-1637. PMID: 28966235

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Spinal Cord Injuries

Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

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Glycyrrhizin extract reduces the development of inflammation and tissue injury events associated with spinal cord trauma.Apr 01, 2009

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Pubmed Data : Shock. 2009 Apr;31(4):367-75. PMID: 18665052

Article Published Date : Apr 01, 2009

Study Type : Animal Study

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Substances : Licorice

Diseases : Spinal Cord Injuries

Pharmacological Actions : Anti-Inflammatory Agents

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Gut dysbiosis could impair recovery after spinal cord injury.Oct 16, 2016

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Pubmed Data : J Exp Med. 2016 Oct 17. Epub 2016 Aug 17. PMID: 27810921

Article Published Date : Oct 16, 2016

Study Type : Animal Study

Additional Links

Diseases : Dysbiosis, Spinal Cord Injuries

Additional Keywords : Microbiota, Risk Factors

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Additional Keywords : Cortisone Alternatives, Superiority of Natural Substances versus Drugs

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Melatonin improves functional recovery as effectively as methylpredisolone in experimental spinal cord injury. Dec 01, 2004

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Pubmed Data : Eur Spine J. 2004 Dec;13(8):724-32. Epub 2004 Jul 1. PMID: 15232723

Article Published Date : Dec 01, 2004

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Spinal Cord Injuries

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Additional Keywords : Cortisone Alternatives, Natural Substances Versus Drugs

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Melatonin is superior to methylprednisolone in experimental spinal cord injury. Jul 01, 2000

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Pubmed Data : J Neurosurg. 2000 Jul;93(1 Suppl):77-84. PMID: 10879762

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Pubmed Data : Life Sci. 2016 Jul 15 ;157:45-51. Epub 2016 May 3. PMID: 27153777

Article Published Date : Jul 14, 2016

Study Type : Animal Study

Additional Links

Substances : Asiatic Acid

Diseases : Oxidative Stress, Spinal Cord Injuries

Pharmacological Actions : Neuroprotective Agents

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Neuroprotective effect of combining tanshinone IIA with low-dose methylprednisolone following acute spinal cord injury.Apr 30, 2017

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Pubmed Data : Exp Ther Med. 2017 May ;13(5):2193-2202. Epub 2017 Mar 28. PMID: 28565827

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Pubmed Data : Biomed Res Int. 2018 ;2018:9865403. Epub 2018 Dec 2. PMID: 30627586

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Paeoniflorin

Diseases : Brain Inflammation , Inflammation, Spinal Cord Injuries

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, NF-kappaB Inhibitor

Additional Keywords : Plant Extracts

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Panax notoginseng saponins improve recovery after spinal cord transection.Jul 31, 2015

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Pubmed Data : Neural Regen Res. 2015 Aug ;10(8):1317-20. PMID: 26487862

Article Published Date : Jul 31, 2015

Study Type : Animal Study

Additional Links

Substances : Panax Notoginseng

Diseases : Spinal Cord Injuries

Pharmacological Actions : Brain-derived neurotrophic factor modulator, Neuroprotective Agents

Additional Keywords : Nerve Regeneration

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Therapeutic Actions : Acupuncture

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Resveratrol exerts neuroprotective effects on spinal cord injury by regulating autophagy and apoptosis.Feb 22, 2017

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Pubmed Data : Neuroscience. 2017 Feb 23. Epub 2017 Feb 23. PMID: 28238848

Article Published Date : Feb 22, 2017

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Spinal Cord Injuries

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Neuroprotective Agents, RESVERATROL, Spinal Cord Injuries

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Resveratrol exhibits superior efficacy versus methylprednisolone, and enhances efficacy in combination, for recovery after experimental spinal cord injury. Oct 01, 2006

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Pubmed Data : Acta Pharmacol Sin. 2006 Oct;27(10):1317-25. PMID: 17007738

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Pubmed Data : Life Sci. 2019 Jan 1 ;216:147-155. Epub 2018 Nov 22. PMID: 30468834

Article Published Date : Dec 31, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Oxidative Stress, Spinal Cord Injuries

Pharmacological Actions : Anti-Apoptotic, Antioxidants, MicroRNA modulator

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Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response.Oct 31, 2019

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Pubmed Data : Neural Regen Res. 2017 Feb ;12(2):267-275. PMID: 28400810

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Pubmed Data : Exp Ther Med. 2017 Dec ;14(6):5583-5588. Epub 2017 Sep 27. PMID: 29285096

Article Published Date : Nov 30, 2017

Study Type : Animal Study

Additional Links

Substances : Delphinidin

Diseases : Spinal Cord Injuries

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation

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This study confirmed the therapeutic efficacy of apocynin in the repair of spinal cord Injuries.Feb 28, 2017

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Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:6493081. Epub 2019 Dec 12. PMID: 31915512

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Coenzyme Q10

Diseases : Glucosephosphate Dehydrogenase Deficiency, Spinal Cord Injuries

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents, Nrf2 activation

Additional Keywords : Mesenchymal Stem Cells

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Curcumin could be of therapeutic use in the treatment of spinal cord injury.Dec 31, 2015

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Pubmed Data : Neurol Res Int. 2016 ;2016:9468193. Epub 2016 May 19. PMID: 27298735

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Pubmed Data : J Mol Neurosci. 2020 Jun 2. Epub 2020 Jun 2. PMID: 32488847

Article Published Date : Jun 01, 2020

Study Type : In Vitro Study

Additional Links

Diseases : Spinal Cord Injuries

Therapeutic Actions : Electroacupuncture

Pharmacological Actions : Antioxidants

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Epigallocatechin-3-gallate (EGCG) prevents the antineuritogenic activity of Nogo-A, a myelin-derived axonal growth inhibitor.Dec 31, 2014

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Pubmed Data : J Neurochem. 2015 Jan ;132(1):70-84. PMID: 25314656

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Spinal Cord Injuries, Stroke: Attenuation/Recovery

Pharmacological Actions : Neuritogenic, Neuroprotective Agents

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Estrogen may have therapeutic value in the treatment of amyotrophic lateral sclerosis and spinal cord injury.Feb 01, 2011

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Inhibition of autophagy is involved in the neuroprotective effects of Ginsenoside Rb1 on spinal cord injury.Jul 30, 2017

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Pubmed Data : Cell Mol Neurobiol. 2017 Jul 31. Epub 2017 Jul 31. PMID: 28762191

Article Published Date : Jul 30, 2017

Study Type : In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Spinal Cord Injuries

Pharmacological Actions : Autophagy Inhibitors, Neuroprotective Agents

Additional Keywords : Autophagy Inhibitors, Ginsenosides, Neuroprotective Agents, Spinal Cord Injuries

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Intermittent fasting and the ketogenic diet may promote neuroprotection and facilitate the regeneration and repair of nerve fibers following injury.Dec 31, 2020

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Pubmed Data : PLoS One. 2021 ;16(1):e0244244. Epub 2021 Jan 4. PMID: 33395427

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Pubmed Data : Neurochem Int. 2015 Aug 12. Epub 2015 Aug 12. PMID: 26277384

Article Published Date : Aug 11, 2015

Study Type : Review

Additional Links

Substances : Resveratrol

Diseases : Spinal Cord Injuries, Stroke: Attenuation/Recovery , Traumatic Brain Injury

Pharmacological Actions : Neuroprotective Agents

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This review provides an overview of current knowledge of palmitoylethanolamide effect on glial functions in the brain.Jan 31, 2013

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Pubmed Data : CNS Neurol Disord Drug Targets. 2013 Feb 1 ;12(1):55-61. PMID: 23394520

Article Published Date : Jan 31, 2013

Study Type : Review

Additional Links

Substances : Palmitoylethanolamide

Diseases : Neurodegenerative Diseases, Neuropathic Pain, Spinal Cord Injuries

Pharmacological Actions : Neuroprotective Agents

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Ashwaganda shows great promise in the treatment of neurodegenerative illnesses such as dementia and spinal cord injury.Aug 01, 2008

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Pubmed Data : Yakugaku Zasshi. 2008 Aug;128(8):1159-67. PMID: 18670181

Article Published Date : Aug 01, 2008

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Diseases : Spinal Cord Injuries

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View the Evidence: 160 Abstracts with Spinal Cord Injuries Research

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Administration of vitamin C and vitamin E in animal models of spinal cord injury significantly improves the recovery of motor function.Dec 03, 2019

Acupuncture may have therapeutic value in treating urinary incontinence associated with spinal cord injuries. Jan 01, 2000

Cannabis extracts can be considered an alternative in patients with spasticity associated with chronic spinal cord injury.Sep 30, 2017

Cranberry extract prevents urinary tract infections in spinal cord injured patients with neurogenic bladder. Sep 01, 2008

Hyperbaric oxygen therapy regulated the inflammatory reaction in secondary spinal cord injury.Oct 31, 2018

Intrathecal CAPE following spinal cord injury decreases tissue and serum IL-6 levels as well as decreases spinal cord edema and microhemorrhage.Dec 31, 2017

Patients with spinal cord injuries and chronic pressure ulcers were treated with Medihoney with significant wound healing and infection control with soft and elastic scars. Jan 31, 2012

Supplementation with creatine may improve muscle strength parameters in individuals with spinal cord injury.Sep 12, 2017

Targeting inflammation through diet in patients after spinal cord injury could help with depressive symptoms. Dec 31, 2014

The effects of acute aerobic exercise on mood and inflammation in individuals with multiple sclerosis and incomplete spinal cord injury.Aug 18, 2019

Vitamin B12 deficiency may aggravate spinal cord injuries. Jan 01, 2003

Whey protein may have therapeutic value in persons with incomplete spinal cord injuries.Feb 01, 2007

Whole-plant cannabis extract can improve intractable neurogenic symptoms. Feb 01, 2003

Yoga intervention reduced depressive symptoms and increased self-compassion in individuals with spinal cord injury.Dec 31, 2016

Immediate therapeutic hypothermia and hyperbaric oxygen therapy could reverse spinal ischemia injury. Dec 31, 2016

Substantial clinical improvement was reported after 2 months of the Ayurvedic treatment in existing neurological deficits and in quality of life.Mar 31, 2015

Improved spinal cord gray matter morphology induced by Spirulina platensis following spinal cord injury in rat models.Jul 19, 2020

Pycnogenol achieves neuroprotective effects in rats with spinal cord injury by stabilizing the mitochondrial membrane potential.Jun 30, 2020

"Neuroprotective effects of sulforaphane after contusive spinal cord injury."Oct 31, 2012

A green tea polyphenol epigallocatechin-3-gallate enhances neuroregeneration after spinal cord injury by altering levels of inflammatory cytokines.Nov 29, 2018

Administration of chlorogenic acid alleviates spinal cord injury.Dec 31, 2017

Aged garlic extract attenuates neuronal injury in a rat model of spinal cord ischemia/reperfusion injury.May 31, 2016

Allicin could be used in protection in traumatic spinal cord injury.Sep 30, 2016

Alpha lipoic acid has a beneficial effect in improving the bladder tonus following spinal cord injury.Aug 03, 2016

Ameliorative effects of echinacoside against spinal cord injury.Nov 14, 2019

Antioxidative effects of alpha-lipoic acid in spinal cord injury.Dec 31, 2020

Astaxanthin attenuates neuroinflammation contributed to the neuropathic pain and motor dysfunction following compression spinal cord injury.Sep 18, 2018

Astaxanthin can inhibit the lipid peroxidation, reduce the apoptosis, reduce the spinal cord edema.Apr 30, 2018

Astaxanthin reduces neuronal apoptosis, diminishes pathological tissue damage and improves functional recovery after spinal cord injury.Apr 21, 2017

Bee venom acupuncture can reduce neuroinflammation and induce recovery in the spinal cord injuries compression model.May 31, 2017

Berberine-loaded M2 macrophage-derived exosomes for spinal cord injury therapy.Mar 11, 2021

Beta-elemene reduces neuronal apoptosis by alleviating endoplasmic reticulum stress in vitro and in vivo.Dec 31, 2017

Carnosol protects against spinal cord injury through Nrf-2 upregulation.Dec 31, 2015

CBD administration attenuated spinal cord injury induced sublesional cancellous bone loss.May 03, 2017

CBD treatment attenuated the development of thermal sensitivity following spinal cord injury.Mar 07, 2018

Celastrol inhibits microglial pyroptosis and attenuates inflammatory reaction in acute spinal cord injury rats.Dec 31, 2018

Chinese skullcap (Scutellaria baicalensis) significantly improves functional recovery from spinal cord injury in rats by inhibiting inflammation and oxidative stress after injury.Aug 01, 2009

Co-ultramicronized palmitoylethanolamide and luteolin promotes neuronal regeneration after spinal cord injury.Dec 31, 2015

Coenzyme Q10 influences on the levels of TNF-α and IL-10 and the ratio of Bax/Bcl2 in a menopausal rat model following lumbar spinal cord injury.May 31, 2018

Crocetin promotes neurite growth and facilitates the recovery of motor and sensorimotor functions after spinal cord injury.Aug 01, 2017

Curcumin can attenuate the downregulation of CISD2 in spinal cord injuries and LPS-treated astrocytes.Aug 07, 2015

Curcumin could have a role in promoting neural function recovery after SCI by the joint inhibition of the intracellular and extracellular components of glial scar.Apr 30, 2015

Curcumin has a profound anti-inflammatory therapeutic potential in the treatment of spinal cord injury.Dec 31, 2015

Curcumin has a protective effect after spinal cord injury. Aug 05, 2009

Curcumin improves early functional results after experimental spinal cord injury.Sep 01, 2010

Curcumin may stimulate recovery from spinal cord injury. Feb 10, 2012

Daidzein ameliorates spinal cord ischemia/reperfusion injury-induced neurological function deficits.Oct 31, 2017

Effect of propolis on neurological recovery after experimental spinal cord injury.Dec 31, 2020

Effects of electroacupuncture on motor function and calpain expression in rats with acute spinal cord injury.Dec 24, 2020

EGCG, the green tea polyphenol, has a protective effecto spinal cord injuries and improves functional recovery. Jan 08, 2010

Electro-acupuncture promotes differentiation of mesenchymal stem cells, regeneration of nerve fibers and partial functional recovery after spinal cord injury.Dec 10, 2009

Electro-acupuncture promotes survival, differentiation of the bone marrow mesenchymal stem cells as well as functional recovery in the spinal cord-transected rats.Jan 01, 2009

Electroacupuncture improves locomotor function by regulating expression of inflammation and oxidative stress-related proteins in mice with spinal cord injury.Nov 24, 2019

Electroacupuncture promoted axonal regeneration in spinal cord injury.Dec 31, 2018

Epicatechin reduces muscle waste after complete spinal cord transection.Nov 04, 2020

Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation.Apr 30, 2010

Folic acid modulates matrix metalloproteinase-9 expression following spinal cord injury.Mar 31, 2019

Gastrodin ameliorates spinal cord injury via antioxidant and anti-inflammatory effects.Dec 31, 2015

Geraniol has a protective effect in traumatic injury of the spinal cord. Nov 30, 2016

Geraniol significantly promoted the recovery of neuronal function and attenuated neuropathic pain after spinal cord injury.Nov 30, 2017

Ginsenoside GRb1 could reduce the cell apoptosis induced by spinal cord ischemia-reperfusion through inhibiting oxidative stress.Aug 13, 2019

Ginsenoside Rb1 has beneficial effects on oxidative stress injury in rat spinal cords.Jul 31, 2018

Ginsenoside Rb1 protects against spinal cord ischemia-reperfusion injury.Sep 01, 2018

Ginsenoside Rd inhibits apoptosis following spinal cord ischemia/reperfusion injury.Sep 14, 2014

Ginsenoside Rg1 may represent a novel treatment target for spinal cord injury.Dec 31, 2016

Glycyrrhizin extract reduces the development of inflammation and tissue injury events associated with spinal cord trauma.Apr 01, 2009

Gut dysbiosis could impair recovery after spinal cord injury.Oct 16, 2016

Hesperidin improves motor disability in rat spinal cord injury.Jan 09, 2020

Huperzine A treatment demonstrates a significant reduction in the number of apoptotic cells in a model of spinal cord injury.Mar 31, 2018

Hyperbaric oxygen therapy after acute thoracic spinal cord injury leads to improvement of locomotor recovery in rats.Aug 22, 2017

Intrathecal CAPE administration following SCI decreases tissue and serum IL-6 levels as well as decreases spinal cord edema and microhemorrage.Apr 26, 2017

Intravenous infusion of magnesium reduced potentially neurotoxic glutamate levels.Aug 07, 2016

Spinal Cord Injuries

View the Evidence:
160 Abstracts with Spinal Cord Injuries Research