Testicular Injury: Chemical/Metal Induced

Name	AC	CK
Curcumin	2	4
Melatonin	1	2
Quercetin	1	2

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Protective effects of rosmarinic acid on doxorubicin-induced testicular damage.Dec 31, 2013

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Pubmed Data : Chemotherapy. 2014 ;60(1):7-12. Epub 2014 Oct 4. PMID: 25301265

Article Published Date : Dec 31, 2013

Study Type : Animal Study

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Substances : Rosmarinic acid

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Oxidative Stress, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Antioxidants, Chemoprotective Agents, Malondialdehyde Down-regulation

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Pubmed Data : Andrologia. 2018 Jul 23:e13085. Epub 2018 Jul 23. PMID: 30039556

Article Published Date : Jul 22, 2018

Study Type : Animal Study

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Substances : Alpha-Lipoic Acid

Diseases : Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Antioxidants

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Ameliorating effects of curcumin on nicotine-induced mice testes.Dec 31, 2015

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Pubmed Data : Turk J Med Sci. 2016 ;46(2):549-60. Epub 2016 Feb 17. PMID: 27511523

Article Published Date : Dec 31, 2015

Study Type : Animal Study

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Substances : Curcumin

Diseases : Testicular Diseases, Testicular Injury: Nicotine-Induced

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Ameliorative effect of curcumin against lead acetate-induced hemato-biochemical alterations, hepatotoxicity, and testicular oxidative damage.Mar 31, 2020

Pubmed Data : Environ Sci Pollut Res Int. 2018 May 22. Epub 2018 May 22. PMID: 29790047

Article Published Date : May 21, 2018

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Testicular Injury: Cadmium-Induced

Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation

Problem Substances : Cadmium

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Asiatic acid attenuates high-fat diet-induced impaired spermatogenesis.Feb 28, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Chem Biol Interact. 2020 Nov 23:109333. Epub 2020 Nov 23. PMID: 33242462

Article Published Date : Nov 22, 2020

Study Type : Animal Study

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Substances : Chlorogenic Acid

Diseases : Arsenic Poisoning, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

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Chrysin protects against testicular toxicity caused by lead acetate.Dec 26, 2020

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Pubmed Data : J Food Biochem. 2020 Dec 27:e13593. Epub 2020 Dec 27. PMID: 33368351

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Pubmed Data : Antioxidants (Basel). 2020 Aug 9 ;9(8). Epub 2020 Aug 9. PMID: 32784851

Article Published Date : Aug 08, 2020

Study Type : Animal Study, In Vitro Study

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Substances : Honokiol

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Chemoprotective Agents

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Crocin attenuates cyclophosphamide induced testicular toxicity by preserving glutathione redox system.Apr 30, 2018

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Pubmed Data : Biomed Pharmacother. 2018 May ;101:174-180. Epub 2018 Feb 24. PMID: 29486335

Article Published Date : Apr 30, 2018

Study Type : Animal Study

Additional Links

Substances : Crocin

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Anti-Apoptotic

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Curcuma longa normalized cimetidine-induced pituitary-testicular dysfunction: Relevance in nutraceutical therapy.Aug 31, 2019

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Pubmed Data : Chemosphere. 2019 Jul 1 ;236:124264. Epub 2019 Jul 1. PMID: 31319301

Article Published Date : Jun 30, 2019

Study Type : Animal Study

Additional Links

Diseases : Bisphenol Toxicity, Infertility: Male, Testicular Injury: Chemical/Metal Induced

Problem Substances : Bisphenol A

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Efficiency of naringin against reproductive toxicity and testicular damages induced by bisphenol A.Feb 28, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Basic Med Sci. 2019 Mar ;22(3):315-523. PMID: 31156794

Article Published Date : Feb 28, 2019

Study Type : Animal Study

Additional Links

Substances : Citrus naringin

Diseases : Bisphenol Toxicity, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Antioxidants, Cytoprotective

Problem Substances : Bisphenol A

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EGCG reduces the testicular oxidative stress induced by arsenic poisoning and thereby protect the reproductive system.Oct 12, 2017

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Pubmed Data : Biomed Pharmacother. 2017 Oct 13 ;96:685-694. Epub 2017 Oct 13. PMID: 29040955

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Pubmed Data : Food Chem Toxicol. 2018 Nov ;121:24-36. Epub 2018 Aug 16. PMID: 30120946

Article Published Date : Oct 31, 2018

Study Type : Animal Study

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Diseases : Bisphenol Toxicity, Lipid Peroxidation, Oxidative Stress, Testicular Injury: Chemical/Metal Induced

Problem Substances : Bisphenol A

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Ferulic acid influences Nrf2 activation to restore testicular tissue from cadmium-induced oxidative challenge, inflammation, and apoptosis.Oct 11, 2020

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Pubmed Data : J Food Biochem. 2020 Oct 12:e13505. Epub 2020 Oct 12. PMID: 33047361

Article Published Date : Oct 11, 2020

Study Type : Animal Study

Additional Links

Substances : Ferulic acid

Diseases : Testicular Injury: Cadmium-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Nrf2 activation

Problem Substances : Cadmium

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Ferulic acid may have future therapeutic relevance in the prevention of lead acetate-induced testicular and renal toxicity.Sep 03, 2019

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Pubmed Data : Environ Sci Pollut Res Int. 2019 Sep 4. Epub 2019 Sep 4. PMID: 31482528

Pubmed Data : Biol Trace Elem Res. 2017 Jun ;177(2):331-344. Epub 2016 Nov 16. PMID: 27854046

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Pubmed Data : J Med Life. 2018 Oct-Dec;11(4):371-380. PMID: 30894897

Article Published Date : Sep 30, 2018

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Pubmed Data : Mol Biol Rep. 2020 Jan 25. Epub 2020 Jan 25. PMID: 31983015

Article Published Date : Jan 24, 2020

Study Type : Animal Study

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Substances : Mulberry

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

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Ketogenic diet improves and restores redox status and biochemical indices in monosodium glutamate-induced rat testicular toxicity. May 16, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Andrologia. 2019 Jul ;51(6):e13274. Epub 2019 Mar 24. PMID: 30907024

Article Published Date : Jun 30, 2019

Study Type : Animal Study

Additional Links

Substances : Lycopene

Diseases : Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Antioxidants

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Male exposure to bisphenol a impairs spermatogenesis and triggers histone hyperacetylation in zebrafish testes.Feb 07, 2019

Article Published Date : Jun 30, 2008

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Oxidative Stress, Testicular Injury: Formaldehyde-Induced

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation

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Melatonin may alleviate the side effects of busulfan for male patients during clinical treatment.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell Physiol Biochem. 2017 ;44(6):2407-2421. Epub 2017 Dec 18. PMID: 29268276

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Cytoprotective

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Melatonin may be a promising pharmacological agent against testicular toxicity induced by high-fructose corn syrup.Jun 04, 2019

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Pubmed Data : Andrologia. 2019 Jun 5:e13327. Epub 2019 Jun 5. PMID: 31168831

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Pubmed Data : J Res Med Sci. 2020 ;25:20. Epub 2020 Feb 20. PMID: 32174992

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Dates

Diseases : Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Cytoprotective

Problem Substances : Morphine

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Palliative effect of curcumin on doxorubicin-induced testicular damage in male rats.Sep 30, 2019

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Pubmed Data : J Biochem Mol Toxicol. 2019 Oct ;33(10):e22384. Epub 2019 Aug 30. PMID: 31468665

Article Published Date : Sep 30, 2019

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Oxidative Stress, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Antioxidants, Chemoprotective Agents, Malondialdehyde Down-regulation

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Parastar negatively affected male reproductive function through alteration of testosterone levels, sperm parameters and induction of oxidative stress.Jun 30, 2018

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Pubmed Data : Toxicol Ind Health. 2018 Jul ;34(7):499-506. Epub 2018 May 7. PMID: 29734926

Article Published Date : Jun 30, 2018

Study Type : Animal Study

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Diseases : Infertility: Male, Oxidative Stress, Pesticide Toxicity , Testicular Injury: Chemical/Metal Induced

Problem Substances : Pesticides

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Paternal bisphenol A exposure induces testis and sperm pathologies in mice.Dec 31, 2020

Pubmed Data : JBRA Assist Reprod. 2019 Apr 30 ;23(2):83-90. Epub 2019 Apr 30. PMID: 30633472

Article Published Date : Apr 29, 2019

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Chemoprotective Agents

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Protective effect of alpha-lipoic acid on di-(2-ethylhexyl) phthalate-induced testicular toxicity in mice.Feb 06, 2020

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Pubmed Data : Environ Sci Pollut Res Int. 2020 Feb 7. Epub 2020 Feb 7. PMID: 32030592

Pubmed Data : Anal Quant Cytopathol Histpathol. 2016 Feb ;38(1):45-51. PMID: 27363066

Article Published Date : Jan 31, 2016

Study Type : Animal Study

Additional Links

Substances : Quercetin

Diseases : Infertility: Male, Oxidative Stress, Testicular Injury: Cadmium-Induced

Pharmacological Actions : Apoptotic, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation

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Red beetroot extract could help prevent chlorpyrifos-induced testicular damage via antioxidant, anti-inflammatory, and anti-apoptotic pathways.Dec 09, 2019

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Pubmed Data : Environ Sci Pollut Res Int. 2019 Dec 10. Epub 2019 Dec 10. PMID: 31823260

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Pubmed Data : Pak J Biol Sci. 2020 Jan ;23(2):173-180. PMID: 31944077

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Rose

Diseases : Chemotherapy-Induced Toxicity: Tamoxifen, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Chemoprotective Agents, Hepatoprotective

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2018 Jul 19 ;23(7). Epub 2018 Jul 19. PMID: 30029485

Article Published Date : Jul 19, 2018

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Heavy Metal Toxicity, Oxidative Stress, Testicular Injury: Cadmium-Induced

Pharmacological Actions : Antioxidants, Apoptotic

Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates

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Synergic effects of aerobic exercise and eugenol supplement on germ cell development and testicular tissue structure in chlorpyrifos-treated animal model.Mar 08, 2020

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Pubmed Data : Environ Sci Pollut Res Int. 2020 Mar 9. Epub 2020 Mar 9. PMID: 32152857

Pubmed Data : Hum Exp Toxicol. 2019 Nov ;38(11):1302-1313. Epub 2019 Jul 18. PMID: 31319718

Article Published Date : Oct 31, 2019

Study Type : Animal Study

Additional Links

Substances : Lycopene

Diseases : Chemotherapy-Induced Toxicity: Gentamicin, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Chemoprotective Agents

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The date palm fruit extract use might have discount effects on formaldehyde-induced testicular toxicity.Mar 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Reprod Biomed (Yazd). 2020 Apr ;18(4):275-286. Epub 2020 Apr 30. PMID: 32494766

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Pubmed Data : Life Sci. 2019 May 25. Epub 2019 May 25. PMID: 31136753

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Reprod Biomed (Yazd). 2019 Apr ;17(4). Epub 2019 May 28. PMID: 31435603

Article Published Date : Mar 31, 2019

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Anti-Apoptotic

Problem Substances : Monosodium Glutamate (MSG)

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Vitamin C has a protective effect against Malathion induced testicular damage.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Andrologia. 2015 Jun ;47(5):553-9. Epub 2014 Jun 11. PMID: 24919929

Click here to read the entire abstract

Pubmed Data : Biol Trace Elem Res. 2018 Feb 4. Epub 2018 Feb 4. PMID: 29397540

Article Published Date : Feb 03, 2018

Study Type : In Vitro Study

Additional Links

Substances : Quercetin

Diseases : Testicular Injury: Cadmium-Induced

Pharmacological Actions : Antioxidants

Additional Keywords : Antioxidants, QUERCETIN, Testicular Injury: Cadmium-Induced

Problem Substances : Cadmium

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Royal jelly protects male mice against nicotine-induced reproductive failure.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Vet Res Forum. 2018 ;9(3):231-238. Epub 2018 Sep 15. PMID: 30357078

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Royal Jelly

Diseases : Infertility: Male, Nicotine/Tobacco Toxicity , Testicular Injury: Nicotine-Induced

Pharmacological Actions : Antioxidants, Fertility Agents: Male

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View the Evidence: 161 Abstracts with Testicular Injury: Chemical/Metal Induced Research

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Protective effects of rosmarinic acid on doxorubicin-induced testicular damage.Dec 31, 2013

Protective role of chrysin on doxorubicin-induced oxidative stress and DNA damage in rat testes.Jul 15, 2020

Activity of resveratrol on the influence of aflatoxin B1 on the testes of Sprague dawley rats.May 31, 2019

Administration of Ficus carica reduces the effects of lead on the seminiferous tubules of adult rat testis.Sep 30, 2018

Administration of Moringa oleifera extract mitigated cyclophosphamide-induced testicular damage.May 14, 2020

Alleviating impact of hydroethanolic Murraya koenigii leaves extract on bisphenol A instigated testicular lethality and apoptosis.Jan 07, 2020

Aloe vera extract can overcome the damaging effects of BPA on the reproductive system of rats and protects rats' testes against BPA-induced toxicity.Jun 30, 2018

Alpha-Lipoic Acid improves the testicular dysfunction in rats induced by varicocele.Jul 22, 2018

Ameliorating effects of curcumin on nicotine-induced mice testes.Dec 31, 2015

Ameliorative effect of curcumin against lead acetate-induced hemato-biochemical alterations, hepatotoxicity, and testicular oxidative damage.Mar 31, 2020

Ameliorative effects of crocin on paraquat-induced oxidative stress in testis.Nov 30, 2019

Ameliorative effects of Spirulina maxima and Allium sativum on lead acetate-induced testicular injury.Jan 31, 2019

Antiapoptotic and antioxidant capacity of phytochemicals from Hibiscus sabdariffa and their potential effects on monosodium glutamate-induced testicular damage.Sep 03, 2020

Antioxidant and anti-apoptotic effects of royal jelly against nicotine-induced testicular injury in mice.May 31, 2019

Ascorbic acid inhibits cadmium-induced disruption of the blood-testis barrier.May 21, 2018

Asiatic acid attenuates high-fat diet-induced impaired spermatogenesis.Feb 28, 2018

Berberis aristata ameliorates testicular toxicity induced by combination of first-line tuberculosis drugs.Dec 31, 2018

Betulinic acid attenuates T-2-toxin-induced testis oxidative damage.Nov 25, 2019

Bisphenol A induced male germ cell apoptosis.Jul 11, 2018

Bisphenol AF and bisphenol F induce similar feminizing effects in chicken embryo testis as bisphenol A.Oct 02, 2020

BPA also disrupted steroidogenesis in the fetal testis organ culture system.Jan 01, 2021

BPA caused marked hypermethylation within Dnmt3A and ER- ∝ genes promoter regions in the testis of rat male pups. Nov 25, 2019

BPA induces physiological and functional disruption in male germ cells.Jul 28, 2020

Burdock has protective effects against ethanol induced testicular injuries.Jul 12, 2018

Caffeic acid phenethyl ester may be protective against damage caused by cisplatin in the testicles.Jul 05, 2020

Caffeine and antioxidants have the ability to reverse cadmium-induced testicular injury.Dec 27, 2020

Chlorella vulgaris ameliorates testicular toxicity induced by deltamethrin.Nov 28, 2018

Chlorogenic acid abates male reproductive dysfunction in arsenic-exposure.Nov 22, 2020

Chrysin protects against testicular toxicity caused by lead acetate.Dec 26, 2020

Coenzyme Q10 ameliorates cadmium induced reproductive toxicity in male rats.Mar 05, 2019

Comparative protective effects of N-acetylcysteine, and melatonin against obesity-induced testicular dysfunction.Nov 16, 2020

Consumption of anthocyanins can be protective against metal-induced male reproductive dysfunction.Jun 30, 2019

Counteracting cisplatin-induced testicular damages by natural polyphenol constituent honokiol.Aug 08, 2020

Crocin attenuates cyclophosphamide induced testicular toxicity by preserving glutathione redox system.Apr 30, 2018

Curcuma longa normalized cimetidine-induced pituitary-testicular dysfunction: Relevance in nutraceutical therapy.Aug 31, 2019

Curcumin and taurine significantly protect BPA induced testicular damage in rats.Apr 30, 2019

Curcumin could ameliorate aluminium induced testicular damage. Sep 30, 2017

Curcumin has a protective effect against cadmium-induced apoptosis in rat testes.Feb 29, 2012

Cyanidin-3- O-glucoside at low doses protected against 3-chloro-1,2-propanediol induced testis injury.Dec 04, 2018

Cyclophosphamide-induced testicular toxicity ameliorate by American ginseng treatment.Oct 31, 2018

Cynara scolymus leaves extract alleviates nandrolone decanoate-induced alterations in testicular function and sperm quality.Jan 31, 2020

Diallyl sulfide seemed to be a promising agent for protection against lead-induced testicular toxicity.Apr 11, 2019

Dichotomy of bisphenol A-induced expression of peroxisome proliferator-activated receptors in hepatic and testicular tissues.Jun 30, 2019

Efficiency of naringin against reproductive toxicity and testicular damages induced by bisphenol A.Feb 28, 2019

EGCG reduces the testicular oxidative stress induced by arsenic poisoning and thereby protect the reproductive system.Oct 12, 2017

Eruca Sativa seed oil treatment had a protective role by reversing histological changes in the testis induced by nicotine administration.Jul 31, 2016

Eugenol has a therapeutic effect on oxidative stress and apoptosis against cisplatin-induced testicular damage.Sep 30, 2019

Exposure to BPA and its analogues for chronic duration can induce structural changes in testicular tissue.Oct 31, 2018

Ferulic acid influences Nrf2 activation to restore testicular tissue from cadmium-induced oxidative challenge, inflammation, and apoptosis.Oct 11, 2020

Ferulic acid may have future therapeutic relevance in the prevention of lead acetate-induced testicular and renal toxicity.Sep 03, 2019

Fluted pumpkin seeds protect against busulfan-induced oxidative stress and testicular injuries.Aug 29, 2019

Folic acid could act as a highly effective fighting approach against lead-associated testicular toxicity.Jun 30, 2017

Formaldehyde exposure induces autophagy in testicular tissues of adult male rats.Feb 28, 2015

Generally, chrysin prophylactic treatment showed a superior testicular protection than mirtazapine at the tested doses.Oct 31, 2017

Gentamicin induces oxidative stress associated with impairment of spermatogenesis, in addition to apoptosis.Jan 25, 2018

Ginseng and banaba leaf extracts could protect against fluoride induced testicular damage. May 31, 2017

Grape seed extract attenuates dexamethasone-induced testicular and thyroid dysfunction.May 31, 2018

Grape seed extract protected against cadmium-induced testicular toxicity.Jan 12, 2020

Green tea extract can be used as a potent antioxidant in the case of para-nonylphenol toxication.Sep 30, 2019

Green tea improves rat sperm quality and reduced cadmium chloride damage effect in spermatogenesis cycle.Sep 30, 2018

Impairment of testicular function in electronic cigarette exposed rats under low-voltage and nicotine-free conditions.Apr 24, 2019

Improvement in colistin-induced reproductive damage, apoptosis, and autophagy in testes via reducing oxidative stress by chrysin.Oct 31, 2018

Inhibitory activity of black mulberry extract against testicular, liver and kidney toxicity induced by paracetamol.Jan 24, 2020

Ketogenic diet improves and restores redox status and biochemical indices in monosodium glutamate-induced rat testicular toxicity. May 16, 2020

Linoleic acid promotes testosterone production by activating leydig cell GPR120/ ERK pathway and restores BPA-impaired testicular toxicity. Jun 21, 2020

Low dose of genistein alleviates phthalate-induced fetal testis disorder.Dec 31, 2019

Low doses of bisphenol S affect post-translational modifications of sperm proteins in male mice. May 27, 2020

Luteolin ameliorates testis injury and blood-testis barrier disruption.Mar 28, 2019

Luteolin protects against testicular injury induced by lead acetate.May 31, 2020

Lycium barbarum polysaccharide protects against ethanol-induced spermiotoxicity and testicular degeneration in Immp2l+/- mice.Apr 30, 2020

Lycopene abrogates di-(2-ethylhexyl) phthalate induced testicular injury.Aug 14, 2018

Lycopene ameliorated benzo[a]pyrene-caused testicular damage via inhibiting oxidative stress and apoptosis.Oct 31, 2019

Testicular Injury: Chemical/Metal Induced

View the Evidence:
161 Abstracts with Testicular Injury: Chemical/Metal Induced Research