Thalassemia

Name	AC	CK
Vitamin E	3	30
Alpha-Lipoic Acid	2	20
Fermented Foods and Beverages	2	20
Papaya	2	20
Curcumin	4	13
Coenzyme Q10	1	10
Homeopathic Medicine: All	1	10
Milk Thistle	1	10
NAC (N-acetyl-L-cysteine)	1	10
Selenium	1	10
Silymarin	1	10
Spirulina	1	10
Vitamin C	1	10
Wheat Grass	1	10
Green Tea	1	2

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Alpha-lipoic acid consumption can be an important complementary therapeutic option to prevent the progression of CVD in β-thalassemia major patients.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Blood Med. 2020 ;11:131-139. Epub 2020 May 7. PMID: 32494211

Article Published Date : Dec 31, 2019

Study Type : Human Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Thalassemia

Pharmacological Actions : Cardioprotective

Additional Keywords : Risk Reduction

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Cardioprotective effects of spirulina therapy in children with beta-thalassemia major.Dec 06, 2018

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Pubmed Data : J Pediatr Hematol Oncol. 2018 Dec 7. Epub 2018 Dec 7. PMID: 30531602

Article Published Date : Dec 06, 2018

Study Type : Human Study

Additional Links

Substances : Spirulina

Diseases : Thalassemia

Pharmacological Actions : Cardioprotective

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Coenzyme Q10 has a beneficial effect as an antioxidant in beta-thalassemia/Hb E patients.Jan 01, 2005

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Pubmed Data : Biofactors. 2005;25(1-4):225-34. PMID: 16873951

Article Published Date : Jan 01, 2005

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10

Diseases : Hemoglobinopathies, Oxidative Stress, Thalassemia

Pharmacological Actions : Antioxidants

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Combined iron-chelation and silymarin therapy was effective for improving the iron-burden status in patients with β-thalassemia major.Dec 12, 2017

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Pubmed Data : Phytother Res. 2017 Dec 13. Epub 2017 Dec 13. PMID: 29235162

Article Published Date : Dec 12, 2017

Study Type : Human Study

Additional Links

Substances : Silymarin

Diseases : Thalassemia

Pharmacological Actions : Iron Chelating Agents

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Curcumin supplementation would be effective in alleviating iron overload in patients with β-thalassemia intermedia.Feb 28, 2022

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Pubmed Data : Clin Lab. 2022 Mar 1 ;68(3). PMID: 35254032

Article Published Date : Feb 28, 2022

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Iron Overload, Thalassemia

Pharmacological Actions : Iron Chelating Agents

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Curcuminoids may be used to ameliorate oxidative damage in patients with beta-thalassemia/Hb E disease.Mar 01, 2010

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Pubmed Data : Clin Biochem. 2010 Mar;43(4-5):424-9. Epub 2009 Nov 10. PMID: 19900435

Article Published Date : Mar 01, 2010

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Hemoglobinopathies, Oxidative Stress, Thalassemia

Pharmacological Actions : Antioxidants, Enzyme Inhibitors

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Fermented papaya alleviates symptoms associated with oxidative stress in severe forms of thalassemia.Jun 01, 2008

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Pubmed Data : Phytother Res. 2008 Jun;22(6):820-8. PMID: 18384199

Article Published Date : Jun 01, 2008

Study Type : Human Study

Additional Links

Substances : Fermented Foods and Beverages, Papaya

Diseases : Oxidative Stress, Thalassemia

Pharmacological Actions : Antioxidants

Additional Keywords : Plant Extracts

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Fermented papaya ameliorates oxidative stress in red blood cells from patients with beta-thalassemia major and intermedia and E-beta-thalassemia . Feb 01, 2010

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Pubmed Data : Phytother Res. 2010 Feb 1. Epub 2010 Feb 1. PMID: 20127662

Article Published Date : Feb 01, 2010

Study Type : Human Study

Additional Links

Substances : Fermented Foods and Beverages, Papaya

Diseases : Thalassemia

Pharmacological Actions : Antioxidants

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NAC can effectively reduce the oxidative status and increase the pre-transfusion hemoglobin levels in children with β-thalassemia major.Nov 02, 2020

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Pubmed Data : Clin Exp Pediatr. 2020 Nov 3. Epub 2020 Nov 3. PMID: 33147909

Article Published Date : Nov 02, 2020

Study Type : Human Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Thalassemia

Pharmacological Actions : Antioxidants

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Pulsatilla Nigricans and Ceanothus Americanus remedies have great potentials in bringing additional benefits to thalassemic patients.Feb 28, 2010

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2010 Mar ;7(1):129-36. Epub 2007 Oct 29. PMID: 18955271

Article Published Date : Feb 28, 2010

Study Type : Human Study

Additional Links

Substances : Homeopathic Medicine: All

Diseases : Thalassemia

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Silymarin significantly imrpoves desferrioxamine treatment outcomes in patients with beta-thalassemia. Jun 01, 2009

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Pubmed Data : Fundam Clin Pharmacol. 2009 Jun;23(3):359-65. Epub 2009 May 7. PMID: 19453758

Article Published Date : Jun 01, 2009

Study Type : Human Study

Additional Links

Substances : Milk Thistle

Diseases : Thalassemia

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The results of this study indicated that supplementation with 600 mg/d alpha lipoic acid may decrease serum ferritin in β-Thalassemia major.Feb 01, 2021

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Pubmed Data : Int J Clin Pract. 2021 Feb 2:e14062. Epub 2021 Feb 2. PMID: 33527721

Article Published Date : Feb 01, 2021

Study Type : Human Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Iron Overload, Thalassemia

Pharmacological Actions : Antioxidants, Hypolipidemic

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Vitamin E and selenium prevent red blood cell oxidation in children with thalassemia. Oct 01, 1993

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Pubmed Data : J Med Assoc Thai. 1993 Oct;76 Suppl 2:146-52. PMID: 7822984

Article Published Date : Oct 01, 1993

Study Type : Human Study

Additional Links

Substances : Selenium, Vitamin E

Diseases : Thalassemia

Pharmacological Actions : Antioxidants

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Vitamin E attenuates oxidative stress-induced changes in thalassemic erythrocytes. Jan 01, 2004

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Pubmed Data : Pol J Pharmacol. 2004 Jan-Feb;56(1):85-96. PMID: 15047982

Article Published Date : Jan 01, 2004

Study Type : Human Study

Additional Links

Substances : Vitamin C, Vitamin E

Diseases : Oxidative Stress, Thalassemia

Pharmacological Actions : Antioxidants

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Vitamin E supplementation can reverse depressed vitamin E levels in thalassaemia owing to increased oxidative stress caused by haemochromatosis. Jan 01, 1986

Click here to read the entire abstract

Pubmed Data : Pediatr Med Chir. 1986 Jan-Feb;8(1):23-6. PMID: 3725609

Article Published Date : Jan 01, 1986

Study Type : Human Study

Additional Links

Substances : Vitamin E

Diseases : Hemochromatosis, Thalassemia

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Wheat grass juice reduces transfusion requirement in patients with thalassemia. Jul 01, 2004

Click here to read the entire abstract

Pubmed Data : Indian Pediatr. 2004 Jul;41(7):716-20. PMID: 15297687

Article Published Date : Jul 01, 2004

Study Type : Human Study

Additional Links

Substances : Wheat Grass

Diseases : Thalassemia

[+]

Therapeutic potential of silymarin as a natural iron-chelating agent in β-thalassemia intermedia.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Clin Case Rep. 2022 Jan ;10(1):e05293. Epub 2022 Jan 24. PMID: 35106163

Article Published Date : Dec 31, 2021

Study Type : Human: Case Report

Additional Links

Substances : Silibinin

Diseases : Thalassemia

Pharmacological Actions : Iron Chelating Agents

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Curcumin may represent a new horizon in managing iron overload-induced toxicity as well as in pathological diseases characterized by hepatic iron accumulation.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2015 ;10(7):e0134156. Epub 2015 Jul 31. PMID: 26230491

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Iron Overload, Myelodysplastic Syndromes, Oxidative Stress, Sickle Cell Anemia, Thalassemia

Pharmacological Actions : Antioxidants, Iron Chelating Agents

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Green tea decreases iron in plasma, eliminates lipid peroxidation in plasma and destroys formation of red blood cell reactive oxygen species. Jul 01, 2008

Click here to read the entire abstract

Pubmed Data : Med Chem. 2008 Jul;4(4):365-70. PMID: 18673149

Article Published Date : Jul 01, 2008

Study Type : Animal Study

Additional Links

Substances : Green Tea

Diseases : Iron Overload, Thalassemia

Pharmacological Actions : Antioxidants

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Curcumin contributes to in vitro removal of iron by the chelation drug deferiprone. Sep 01, 2007

Click here to read the entire abstract

Pubmed Data : Med Chem. 2007 Sep;3(5):469-74. PMID: 17897073

Article Published Date : Sep 01, 2007

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Thalassemia

Additional Keywords : Drug-Plant-Vitamin Synergies

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EGCG decreases plasma iron and red blood cell oxidative stress and may provide a therapeutic alternative to conventional chelation drugs. May 01, 2007

Click here to read the entire abstract

Pubmed Data : Med Chem. 2007 May;3(3):289-96. PMID: 17504202

Article Published Date : May 01, 2007

Study Type : In Vitro Study

Additional Links

Diseases : Thalassemia

Additional Keywords : Natural Substances Versus Drugs

[+]

Curcuminoids alleviate iron overload and lipid peroxidation in thalassemic mice. Sep 01, 2009

Click here to read the entire abstract

Pubmed Data : Med Chem. 2009 Sep 1.PMID:19534681

Article Published Date : Sep 01, 2009

Additional Links

Substances : Curcumin

Diseases : Iron Overload, Thalassemia

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View the Evidence: 22 Abstracts with Thalassemia Research

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Alpha-lipoic acid consumption can be an important complementary therapeutic option to prevent the progression of CVD in β-thalassemia major patients.Dec 31, 2019

Cardioprotective effects of spirulina therapy in children with beta-thalassemia major.Dec 06, 2018

Coenzyme Q10 has a beneficial effect as an antioxidant in beta-thalassemia/Hb E patients.Jan 01, 2005

Combined iron-chelation and silymarin therapy was effective for improving the iron-burden status in patients with β-thalassemia major.Dec 12, 2017

Curcumin supplementation would be effective in alleviating iron overload in patients with β-thalassemia intermedia.Feb 28, 2022

Curcuminoids may be used to ameliorate oxidative damage in patients with beta-thalassemia/Hb E disease.Mar 01, 2010

Fermented papaya alleviates symptoms associated with oxidative stress in severe forms of thalassemia.Jun 01, 2008

Fermented papaya ameliorates oxidative stress in red blood cells from patients with beta-thalassemia major and intermedia and E-beta-thalassemia . Feb 01, 2010

NAC can effectively reduce the oxidative status and increase the pre-transfusion hemoglobin levels in children with β-thalassemia major.Nov 02, 2020

Pulsatilla Nigricans and Ceanothus Americanus remedies have great potentials in bringing additional benefits to thalassemic patients.Feb 28, 2010

Silymarin significantly imrpoves desferrioxamine treatment outcomes in patients with beta-thalassemia. Jun 01, 2009

The results of this study indicated that supplementation with 600 mg/d alpha lipoic acid may decrease serum ferritin in β-Thalassemia major.Feb 01, 2021

Vitamin E and selenium prevent red blood cell oxidation in children with thalassemia. Oct 01, 1993

Vitamin E attenuates oxidative stress-induced changes in thalassemic erythrocytes. Jan 01, 2004

Vitamin E supplementation can reverse depressed vitamin E levels in thalassaemia owing to increased oxidative stress caused by haemochromatosis. Jan 01, 1986

Wheat grass juice reduces transfusion requirement in patients with thalassemia. Jul 01, 2004

Therapeutic potential of silymarin as a natural iron-chelating agent in β-thalassemia intermedia.Dec 31, 2021

Curcumin may represent a new horizon in managing iron overload-induced toxicity as well as in pathological diseases characterized by hepatic iron accumulation.Dec 31, 2014

Green tea decreases iron in plasma, eliminates lipid peroxidation in plasma and destroys formation of red blood cell reactive oxygen species. Jul 01, 2008

Curcumin contributes to in vitro removal of iron by the chelation drug deferiprone. Sep 01, 2007

EGCG decreases plasma iron and red blood cell oxidative stress and may provide a therapeutic alternative to conventional chelation drugs. May 01, 2007

Curcuminoids alleviate iron overload and lipid peroxidation in thalassemic mice. Sep 01, 2009

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Thalassemia

View the Evidence:
22 Abstracts with Thalassemia Research