Traumatic Brain Injury

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23 Substances Researched for Traumatic Brain Injury
NameACCKFocus
Acetyl-l-carnitine110Locked
Alpha-Lipoic Acid110Locked
Fish Oil110Locked
Ginkgo biloba110Locked
Huperzine110Locked
Multivitamin110Locked
NAC (N-acetyl-L-cysteine)110Locked
Vinpocetine110Locked
Resveratrol34Locked
Sulforaphane24Locked
Thymoquinone23Locked
Cannabinoids 12Locked
Choline12Locked
Coenzyme Q1012Locked
Crocin12Locked
Ellagic Acid12Locked
Endocannabinoids12Locked
Genistein12Locked
Melatonin12Locked
Vitamin C12Locked
Vitamin E: alpha tocopherol12Locked
Nigella sativa (aka Black Seed)11Locked
Pterostilbene11Locked
1 Problem Substances Researched for Traumatic Brain Injury
NameACCKFocus
Clopidogrel110Locked
4 Therapeutic Actions Researched for Traumatic Brain Injury
NameACCKFocus
Light-Emitting Diodes (LEDs) Therapy110Locked
Acupuncture26Locked
Hyperbaric Treatment23Locked
Laser Treatment: Low-Level11Locked

View the Evidence:
77 Abstracts with Traumatic Brain Injury Research

[+]

Acupuncture can be an effective treatment for patients unconscious following traumatic brain injury.Feb 20, 2020

Pubmed Data : Altern Ther Health Med. 2020 Feb 21. Epub 2020 Feb 21. PMID: 32088667
Article Published Date : Feb 20, 2020
Study Type : Meta Analysis, Review
Additional Links
Diseases : Traumatic Brain Injury
Therapeutic Actions : Acupuncture
Pharmacological Actions : Neuroprotective Agents
[+]

Patients undergoing hyperbaric therapy achieved significant improvement in the GCS and GOS with a lower overall mortality.Apr 30, 2016

Pubmed Data : Neurol Sci. 2016 May ;37(5):693-701. Epub 2016 Jan 8. PMID: 26746238
Article Published Date : Apr 30, 2016
Study Type : Meta Analysis
Additional Links
Diseases : Traumatic Brain Injury
Additional Keywords : Significant Treatment Outcome
[+]

Therapeutic effects of meditation, yoga, and mindfulness-based interventions for chronic symptoms of mild traumatic brain injury.Nov 01, 2020

Pubmed Data : Appl Psychol Health Well Being. 2020 Nov 2. Epub 2020 Nov 2. PMID: 33136346
Article Published Date : Nov 01, 2020
Study Type : Meta Analysis, Review
Additional Links
Diseases : Traumatic Brain Injury
Therapeutic Actions : Meditation , Mindfullness Training, Yoga
Pharmacological Actions : Neuroprotective Agents
[+]

A nutrient combination improves cognitive function in head injuried former NFL players. Jan 01, 2011

Pubmed Data : J Psychoactive Drugs. 2011 Jan-Mar;43(1):1-5. PMID: 21615001
Article Published Date : Jan 01, 2011
Study Type : Human Study
Additional Links
Substances : Acetyl-l-carnitine, Alpha-Lipoic Acid, Fish Oil, Ginkgo biloba, Huperzine, Multivitamin, NAC (N-acetyl-L-cysteine), Vinpocetine
Diseases : Brain Damage, Head Injuries, Traumatic Brain Injury
Pharmacological Actions : Neurorestorative
[+]

Acupuncture treatment increased the cortico spinal tract activity of patients with chronic chronic disorders of consciousness after severe TBI.Oct 31, 2016

Pubmed Data : J Altern Complement Med. 2016 Nov ;22(11):887-894. Epub 2016 Sep 23. PMID: 27662495
Article Published Date : Oct 31, 2016
Study Type : Human Study
Additional Links
Diseases : Traumatic Brain Injury
Therapeutic Actions : Acupuncture
[+]

HBOT was significantly effective for veterans with mild to moderate traumatic brain injury with persistent post-concussion syndrome and PTSD.Jun 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Gas Res. 2017 Jul-Sep;7(3):156-174. Epub 2017 Oct 17. PMID: 29152209
Article Published Date : Jun 30, 2017
Study Type : Human Study
Additional Links
Diseases : Brain Concussion, Post-Traumatic Stress Disorders (PTSD), Suicidal Ideation, Traumatic Brain Injury
Therapeutic Actions : Hyperbaric Treatment
Additional Keywords : Medication Reduction, Significant Treatment Outcome
[+]

Hyperbaric oxygen therapy can induce angiogenesis and regeneration of nerve fibers in traumatic brain injury patients.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Hum Neurosci. 2017 ;11:508. Epub 2017 Oct 19. PMID: 29097988
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Diseases : Traumatic Brain Injury
Therapeutic Actions : Hyperbaric Treatment
Pharmacological Actions : Regenerative
[+]

Hyperbaric oxygen therapy for mild traumatic brain injury persistent postconcussion syndrome.Dec 31, 2019

Pubmed Data : Med Gas Res. 2020 Jan-Mar;10(1):8-20. PMID: 32189664
Article Published Date : Dec 31, 2019
Study Type : Human Study
Additional Links
Diseases : Brain Concussion, Traumatic Brain Injury
Therapeutic Actions : Hyperbaric Treatment
Pharmacological Actions : Neuroprotective Agents
[+]

Increased circulating stem cells and better cognitive performance was seen in traumatic brain injury subjects following hyperbaric oxygen therapy.Apr 30, 2017

Pubmed Data : Undersea Hyperb Med. 2017 May-Jun;44(3):257-269. PMID: 28779582
Article Published Date : Apr 30, 2017
Study Type : Human Study
Additional Links
Diseases : Traumatic Brain Injury
Therapeutic Actions : Hyperbaric Treatment
Pharmacological Actions : Neuroprotective Agents
[+]

Transcranial LED treatment improved sleep and led to fewer post-traumatic stress disorder symptoms.May 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neurotrauma. 2014 Jun 1 ;31(11):1008-17. Epub 2014 May 8. PMID: 24568233
Article Published Date : May 31, 2014
Study Type : Human Study
Additional Links
Diseases : Traumatic Brain Injury
Therapeutic Actions : Light-Emitting Diodes (LEDs) Therapy
[+]

Traumatic brain injury patients on clopidogrel may have increased long-term disability and fatal consequences when compared with patients who are not on these drugs or on other anticoagulants. Dec 01, 2008

Pubmed Data : J Trauma. 2008 Dec;65(6):1303-8. PMID: 19077618
Article Published Date : Dec 01, 2008
Study Type : Human Study
Additional Links
Diseases : Traumatic Brain Injury
Problem Substances : Clopidogrel
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Yoga-based physical therapy is feasible and safe in the inpatient rehabilitation setting following traumatic brain injury.Jun 11, 2020

Pubmed Data : Brain Inj. 2020 Jun 12:1-9. Epub 2020 Jun 12. PMID: 32530717
Article Published Date : Jun 11, 2020
Study Type : Human Study
Additional Links
Diseases : Traumatic Brain Injury
Therapeutic Actions : Yoga
[+]

A case report of restoration of function with acupuncture following severe traumatic brain injury.Oct 31, 2015

Pubmed Data : Glob Adv Health Med. 2015 Nov ;4(6):52-7. Epub 2015 Nov 1. PMID: 26665023
Article Published Date : Oct 31, 2015
Study Type : Human: Case Report
Additional Links
Diseases : Traumatic Brain Injury
Therapeutic Actions : Acupuncture
[+]

A patient reported rapid and significant improvements in pain and mood during a course of acupuncture treatment. Aug 31, 2006

Pubmed Data : Acupunct Med. 2006 Sep ;24(3):129-33. PMID: 17013360
Article Published Date : Aug 31, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Central Pain Syndrome, Fractures: Bone, Traumatic Brain Injury
Therapeutic Actions : Acupuncture
Pharmacological Actions : Analgesics
Additional Keywords : Significant Treatment Outcome
[+]

Administration of synthetic 2-AG to mice after CHI led to significant reduction of brain oedema, better clinical recovery, reduced infarct volume and reduced hippocampal cell death compared with controls.Oct 03, 2001

Pubmed Data : Nature. 2001 Oct 4 ;413(6855):527-31. PMID: 11586361
Article Published Date : Oct 03, 2001
Study Type : Animal Study
Additional Links
Substances : Cannabinoids , Endocannabinoids
Diseases : Brain Edema, Brain Inflammation , Traumatic Brain Injury
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
Additional Keywords : Significant Treatment Outcome
[+]

Allyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2/HO-1 and NF-κB pathways in traumatic brain injury.Jan 31, 2019

Pubmed Data : Mol Biol Rep. 2019 Feb ;46(1):241-250. Epub 2018 Nov 8. PMID: 30406889
Article Published Date : Jan 31, 2019
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Brain: Oxidative Stress, Inflammation, Traumatic Brain Injury
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Nrf2 activation
[+]

Astaxanthin ameliorates oxidative stress and neuronal apoptosis after traumatic brain injury in mice.Dec 15, 2020

Pubmed Data : Br J Pharmacol. 2020 Dec 16. Epub 2020 Dec 16. PMID: 33326114
Article Published Date : Dec 15, 2020
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Brain: Oxidative Stress, Traumatic Brain Injury
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Auricular electroacupuncture can reduce the incidence of late post-traumatic epilepsy.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:5798912. Epub 2019 Oct 13. PMID: 31737082
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Diseases : Epilepsy, Traumatic Brain Injury
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Neuroprotective Agents
[+]

Chrysin could be beneficial for protection against traumatic brain injury-associated behavioural deficits.Feb 21, 2020

Pubmed Data : Psychopharmacology (Berl). 2020 Feb 22. Epub 2020 Feb 22. PMID: 32088834
Article Published Date : Feb 21, 2020
Study Type : Animal Study
Additional Links
Substances : Chrysin
Diseases : Memory Disorders, Traumatic Brain Injury
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Cognitive effects of astaxanthin pretreatment on recovery from traumatic brain injury.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurol. 2020 ;11:999. Epub 2020 Oct 15. PMID: 33178093
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
[+]

Dietary choline supplementation improves behavioral, histological, and neurochemical outcomes in a rat model of traumatic brain injury.Aug 01, 2008

Pubmed Data : J Neurotrauma. 2008 Aug;25(8):975-83. PMID: 18665805
Article Published Date : Aug 01, 2008
Study Type : Animal Study
Additional Links
Substances : Choline
Diseases : Brain Inflammation , Traumatic Brain Injury
[+]

Diosmin improved cognitive deficit and amplified brain electrical activity in the rat model of traumatic brain injury.Aug 31, 2017

Pubmed Data : Biomed Pharmacother. 2017 Sep ;93:1220-1229. Epub 2017 Jul 20. PMID: 28738538
Article Published Date : Aug 31, 2017
Study Type : Animal Study
Additional Links
Substances : Diosmin
Diseases : Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Effects of caffeic acid phenethyl ester in reducing cerebral edema.Aug 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Med Surg (Lond). 2020 Sep ;57:328-333. Epub 2020 Aug 15. PMID: 32874565
Article Published Date : Aug 31, 2020
Study Type : Animal Study
Additional Links
Substances : Caffeic acid phenethyl ester
Diseases : Brain Edema, Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
[+]

Ellagic acid can restore neurologic severity score, cognitive and long-term potentiation deficits and prevent brain inflammation.Mar 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2017 Apr ;20(4):399-407. PMID: 28804609
Article Published Date : Mar 31, 2017
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid
Diseases : Traumatic Brain Injury
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ellagic acid may be used in functional foods or medicines to help treat nerve dysfunction, neurodegenerative disease and aging.Oct 28, 2016

Pubmed Data : Mol Nutr Food Res. 2016 Oct 29. Epub 2016 Aug 29. PMID: 27794200
Article Published Date : Oct 28, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ellagic Acid
Diseases : Neurodegenerative Diseases, Traumatic Brain Injury
Pharmacological Actions : Wnt/β-catenin signaling pathway modulation
[+]

Ellagic acid prevents cognitive and hippocampal long-term potentiation deficits and brain inflammation in rat with traumatic brain injury.Feb 28, 2015

Pubmed Data : Life Sci. 2015 Mar 1 ;124:120-7. Epub 2015 Jan 28. PMID: 25637685
Article Published Date : Feb 28, 2015
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid
Diseases : Brain Inflammation , Memory Disorders, Traumatic Brain Injury
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents
[+]

Hydrogen rich water can up-regulate the expression of Nrf2, and reduce oxidative damage of traumatic brain injury.Oct 31, 2015

Pubmed Data : Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Nov ;27(11):911-5. PMID: 27132459
Article Published Date : Oct 31, 2015
Study Type : Animal Study
Additional Links
Substances : Hydrogen Water
Diseases : Oxidative Stress, Traumatic Brain Injury
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Hyperbaric oxygen has a neuroprotective role in traumatic brain injury.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Genet Mol Res. 2016 ;15(1). Epub 2016 Jan 29. PMID: 26909929
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Diseases : Traumatic Brain Injury
Therapeutic Actions : Hyperbaric Treatment
Pharmacological Actions : Anti-Apoptotic, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Hyperbaric oxygen promotes neural stem cell proliferation after traumatic brain injury.Sep 24, 2017

Pubmed Data : Neuroreport. 2017 Sep 25. Epub 2017 Sep 25. PMID: 28953090
Article Published Date : Sep 24, 2017
Study Type : Animal Study
Additional Links
Diseases : Traumatic Brain Injury
Therapeutic Actions : Hyperbaric Treatment
Pharmacological Actions : Neuroprotective Agents
[+]

Hyperbaric oxygen therapy treatment improves the cumulative tissue damage in juvenile brain following repetitive mild traumatic brain injury.Sep 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Gas Res. 2016 Oct-Dec;6(4):187-193. Epub 2016 Dec 30. PMID: 28217290
Article Published Date : Sep 30, 2016
Study Type : Animal Study
Additional Links
Diseases : Traumatic Brain Injury
Therapeutic Actions : Hyperbaric Treatment
Pharmacological Actions : Neuroprotective Agents
[+]

Hyperbaric oxygen therapy treatment may ameliorate TBI-induced depression-like behaviour in rats by attenuating neuro-inflammation.Jan 04, 2017

Pubmed Data : World Neurosurg. 2017 Jan 5. Epub 2017 Jan 5. PMID: 28065873
Article Published Date : Jan 04, 2017
Study Type : Animal Study
Additional Links
Diseases : Brain Inflammation , Traumatic Brain Injury
Therapeutic Actions : Hyperbaric Treatment
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Inhibition of NOX2 contributes to the therapeutic effect of aloin on traumatic brain injury.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Folia Neuropathol. 2020 ;58(3):265-274. PMID: 33099296
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Aloe Vera
Diseases : Traumatic Brain Injury
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage.Jun 12, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neuroinflammation. 2017 Jun 13 ;14(1):119. Epub 2017 Jun 13. PMID: 28610608
Article Published Date : Jun 12, 2017
Study Type : Animal Study
Additional Links
Substances : Isoliquiritigenin
Diseases : Intracerebral Hemorrhage, Traumatic Brain Injury
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Lactobacillus acidophilus exerts neuroprotective effects in mice with traumatic brain injury.Jun 06, 2019

Pubmed Data : J Nutr. 2019 Jun 7. Epub 2019 Jun 7. PMID: 31174208
Article Published Date : Jun 06, 2019
Study Type : Animal Study
Additional Links
Substances : Lactobacillus Acidophilus
Diseases : Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
[+]

Magnesium administration after experimental traumatic brain injury improves decision-making skills.Apr 30, 2018

Pubmed Data : Brain Res Bull. 2018 May ;139:182-189. Epub 2018 Mar 1. PMID: 29501800
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : magnesium chloride
Diseases : Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
[+]

Melatonin attenuates sepsis induced brain injury via activation SIRT1 signaling activation.Jun 09, 2015

Pubmed Data : J Pineal Res. 2015 Jun 10. Epub 2015 Jun 10. PMID: 26094939
Article Published Date : Jun 09, 2015
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Brain: Oxidative Stress, Brain Inflammation , Sepsis, Traumatic Brain Injury
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, SIRT1 Activator, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Significant Treatment Outcome
[+]

Neuronal degenerative findings and the secondary brain damage and ischemia caused by oxidative stress are decreased by CoQ10 use in rats with traumatic brain injury.Jan 01, 2011

Pubmed Data : BMC Neurosci. 2011 ;12:75. Epub 2011 Jul 29. PMID: 21801363
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Substances : Coenzyme Q10
Diseases : Brain Damage, Brain Ischemia, Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
[+]

Neuroprotective effect of artesunate in experimental model of traumatic brain injury.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurol. 2018 ;9:590. Epub 2018 Jul 31. PMID: 30108544
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Artesunate
Diseases : Traumatic Brain Injury
Pharmacological Actions : Anti-Inflammatory Agents, Brain-derived neurotrophic factor modulator, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Neuroprotective effect of berberine against learning and memory deficits in diffuse axonal injuryDec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2018 Jan ;15(1):1129-1135. Epub 2017 Nov 13. PMID: 29399112
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Learning disorders, Traumatic Brain Injury
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Neuroprotective effect of berberine agonist against impairment of learning and memory skills in severe traumatic brain injury.Mar 04, 2018

Pubmed Data : Mol Med Rep. 2018 Mar 5. Epub 2018 Mar 5. PMID: 29512719
Article Published Date : Mar 04, 2018
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Traumatic Brain Injury
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Matrix metalloproteinase-3 (MMP-3) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Neuroprotective Agents
[+]

Oleocanthal has a protective effect on neural cells after traumatic brain injury.Oct 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Turk Neurosurg. 2017 Nov 1. Epub 2017 Nov 1. PMID: 29204981
Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Oleocanthal, Olive Oil
Diseases : Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
[+]

Palmitoylethanolamide reduces neuropsychiatric behaviours by restoring cortical electrophysiological activity in a model of mild traumatic brain injury.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2017 ;8:95. Epub 2017 Mar 6. PMID: 28321191
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
[+]

Pre and post treatment with ascorbic acid and α-tocopherol reduced oxidative stress induced by brain injury and effectively reduced mortality rate in rats.Jun 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neurosci Rural Pract. 2013 Jul ;4(3):292-7. PMID: 24250162
Article Published Date : Jun 30, 2013
Study Type : Animal Study
Additional Links
Substances : Vitamin C, Vitamin E: alpha tocopherol
Diseases : Brain: Oxidative Stress, Traumatic Brain Injury
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents
Additional Keywords : Significant Treatment Outcome
[+]

Propolis may protect brain cell from apoptosis after injury by maintaining Hsp70 expression in addition to antioxidant and anti-inflammatory.Sep 14, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Open Access Maced J Med Sci. 2019 Sep 15 ;7(17):2763-2766. Epub 2019 Aug 30. PMID: 31844433
Article Published Date : Sep 14, 2019
Study Type : Animal Study
Additional Links
Substances : Propolis: Bee
Diseases : Traumatic Brain Injury
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heat Shock Protein Inducer, Neuroprotective Agents
[+]

Quercetin protects rat cortical neurons against traumatic brain injury.Mar 27, 2018

Pubmed Data : Mol Med Rep. 2018 Mar 28. Epub 2018 Mar 28. PMID: 29620218
Article Published Date : Mar 27, 2018
Study Type : Animal Study
Additional Links
Substances : Quercetin
Diseases : Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
[+]

Resveratrol attenuates behavioral impairments and reduces cortical and hippocampal loss in a rat controlled cortical impact model of traumatic brain injury.Jun 01, 2010

Pubmed Data : J Neurotrauma. 2010 Jun;27(6):1091-9. PMID: 20560755
Article Published Date : Jun 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Brain Injury: Hippocampal Damage, Traumatic Brain Injury
Pharmacological Actions : Apoptotic, Neuroprotective Agents
Additional Keywords : Stilbenes
[+]

Sesamin may be a promising potential therapeutic intervention for preventing disruption of the blood brain barrier after traumatic brain injury.Aug 02, 2017

Pubmed Data : Acta Pharmacol Sin. 2017 Aug 3. Epub 2017 Aug 3. PMID: 28770828
Article Published Date : Aug 02, 2017
Study Type : Animal Study
Additional Links
Substances : Sesamin
Diseases : Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Blood Brain Barrier
[+]

Sesamin protected SH-SY5Y cells against stretch injury by attenuating increases in ROS levels and suppressing apoptosis.Aug 06, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Neurosci. 2017 Aug 7 ;18(1):57. Epub 2017 Aug 7. PMID: 28784087
Article Published Date : Aug 06, 2017
Study Type : Animal Study
Additional Links
Substances : Sesamin
Diseases : Traumatic Brain Injury
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Silymarin can significantly reduce anxiety and depression-like symptoms, and neuroinflammation after mild traumatic brain injury.Dec 31, 2017

Pubmed Data : Toxicol Appl Pharmacol. 2018 Jan 1 ;338:159-173. Epub 2017 Nov 22. PMID: 29175455
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Silymarin
Diseases : Depression, Traumatic Brain Injury
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Natural Substances Versus Drugs
Problem Substances : Fluoxetine (trade name Prozac)
[+]

Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury.Nov 15, 2005

Pubmed Data : J Neurosci Res. 2005 Nov 15;82(4):499-506. PMID: 16211562
Article Published Date : Nov 15, 2005
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Brain Edema, Traumatic Brain Injury
[+]

Sulforphane attenuates oxidative stress and neuronal damage following traumatic brain injury. Oct 18, 2010

Pubmed Data : Acta Pharmacol Sin. 2010 Oct 18. Epub 2010 Oct 18. PMID: 20953205
Article Published Date : Oct 18, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Brain Injury: Traumatic, Traumatic Brain Injury
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Tauroursodeoxycholic acid may attenuate early brain injury via Akt pathway activation.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cell Neurosci. 2017 ;11:193. Epub 2017 Jul 6. PMID: 28729823
Article Published Date : Dec 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Tauroursodeoxycholic acid
Diseases : Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
[+]

Tetrahydrocurcumin provides neuroprotection in experimental traumatic brain injury.Dec 31, 2016

Pubmed Data : Neuroimmunomodulation. 2017 ;24(6):348-355. Epub 2018 Apr 18. PMID: 29669346
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Tetrahydrocurcumin
Diseases : Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents, Nrf2 activation
[+]

The benefits of voluntary physical exercise after traumatic brain injury on rat's object recognition memory.Jan 07, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Neurol. 2020 Jan 8:113178. Epub 2020 Jan 8. PMID: 31926165
Article Published Date : Jan 07, 2020
Study Type : Animal Study
Additional Links
Diseases : Traumatic Brain Injury
Therapeutic Actions : Exercise
Pharmacological Actions : Neurogenesis, Neuroprotective Agents
[+]

The results of this study demonstrated that genistein can be neuroprotective in traumatic brain injury. Sep 10, 2015

Pubmed Data : Physiol Behav. 2015 Sep 11 ;152(Pt A):26-31. Epub 2015 Sep 11. PMID: 26367454
Article Published Date : Sep 10, 2015
Study Type : Animal Study
Additional Links
Substances : Genistein
Diseases : Brain Edema, Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
[+]

Therapeutic effects of chrysin in a model of traumatic brain injuryJun 30, 2019

Pubmed Data : Life Sci. 2019 Jul 1 ;228:285-294. Epub 2019 May 4. PMID: 31063733
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Chrysin
Diseases : Brain: Oxidative Stress, Learning disorders, Memory Disorders, Traumatic Brain Injury
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents
[+]

These findings demonstrated that low-molecular-weight fucoidan exerts neuroprotection against traumatic brain injury in the aged brain.Oct 31, 2016

Pubmed Data : Cell Mol Neurobiol. 2016 Nov ;36(8):1257-1268. Epub 2016 Jan 7. PMID: 26743530
Article Published Date : Oct 31, 2016
Study Type : Animal Study
Additional Links
Substances : Fucoidan
Diseases : Oxidative Stress, Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
[+]

These results suggest that crocin has neuroprotective effects against traumatic brain injury in mice.Mar 29, 2015

Pubmed Data : Neurosci Lett. 2015 Mar 30 ;591:53-8. Epub 2015 Feb 11. PMID: 25681620
Article Published Date : Mar 29, 2015
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
[+]

This study indicates that tetrahydrocurcumin protects neurons from traumatic brain injury-induced apoptotic neuronal death.Oct 31, 2016

Pubmed Data : J Surg Res. 2016 Nov ;206(1):67-76. Epub 2016 Jul 15. PMID: 27916377
Article Published Date : Oct 31, 2016
Study Type : Animal Study
Additional Links
Substances : Tetrahydrocurcumin
Diseases : Traumatic Brain Injury
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Thymoquinone has a healing effect on neural cells after head injury and this effect is mediated by decreasing MDA levels.Sep 29, 2015

Pubmed Data : World Neurosurg. 2015 Sep 30. Epub 2015 Sep 30. PMID: 26428323
Article Published Date : Sep 29, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Traumatic Brain Injury
Pharmacological Actions : Malondialdehyde Down-regulation, Neuroprotective Agents
[+]

Ubiquinol preserves mitochondria and reduces cellular injury severity after traumatic brain injury.Jan 29, 2018

Pubmed Data : J Neurosci Res. 2018 Jan 30. Epub 2018 Jan 30. PMID: 29380912
Article Published Date : Jan 29, 2018
Study Type : Animal Study
Additional Links
Substances : Ubiquinol
Diseases : Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
[+]

Withaferin A alleviates traumatic brain injury induced secondary brain injury via suppressing apoptosis in endothelia cells and modulating activation in the microglia.May 04, 2020

Pubmed Data : Eur J Pharmacol. 2020 May 5 ;874:172988. Epub 2020 Feb 4. PMID: 32032599
Article Published Date : May 04, 2020
Study Type : In Vitro Study
Additional Links
Substances : Ashwagandha
Diseases : Traumatic Brain Injury
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

A review of the promising therapeutic potential of pterostilbene.Jul 26, 2016

Pubmed Data : Eur J Pharmacol. 2016 Jul 27 ;789:229-243. Epub 2016 Jul 27. PMID: 27475678
Article Published Date : Jul 26, 2016
Study Type : Review
Additional Links
Substances : Pterostilbene
Diseases : Cancers: All, Cardiovascular Diseases, Traumatic Brain Injury
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Curcumin could increase the levels of BDNF, GAP-43, ICAM, and Nrf2 and attenuate brain injury in the model of traumatic brain injury.May 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Curr Dev Nutr. 2019 Jun ;3(Suppl 1). Epub 2019 Jun 13. PMID: 31225014
Article Published Date : May 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Curcuma Longa
Diseases : Traumatic Brain Injury
Pharmacological Actions : Antioxidants, Brain-derived neurotrophic factor modulator, Neuroprotective Agents, Nrf2 activation
[+]

Glycyrrhizin improved the neurological function recovery, reduced the lesion volume, and inhibited the release and expression of HMGB1 after TBI.Jan 25, 2018

Pubmed Data : Biochem Biophys Res Commun. 2018 02 26 ;497(1):430-436. Epub 2018 Feb 12. PMID: 29448108
Article Published Date : Jan 25, 2018
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
[+]

High-dose intravenous vitamin C may prove an effective strategy to prevent or mitigate secondary brain injury.Dec 31, 2019

Pubmed Data : Neurocrit Care. 2020 02 ;32(1):333-339. PMID: 31440996
Article Published Date : Dec 31, 2019
Study Type : Commentary
Additional Links
Substances : Vitamin C: Intravenous
Diseases : Brain: Oxidative Stress, Traumatic Brain Injury
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Hyperbaric oxygen therapy alleviates the inflammatory response in experimental traumatic brain injury.Sep 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2017 Oct ;16(4):3922-3928. Epub 2017 Jul 24. PMID: 29067455
Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Diseases : Traumatic Brain Injury
Therapeutic Actions : Hyperbaric Treatment
Pharmacological Actions : anti-inflammatory, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
[+]

Hyperbaric oxygen therapy has been demonstrated to have neuroprotective effects without increased oxygen toxicity in experimental TBI models.Mar 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Gas Res. 2016 Apr-Jun;6(2):102-110. Epub 2016 Jul 11. PMID: 27867476
Article Published Date : Mar 31, 2016
Study Type : Review
Additional Links
Diseases : Traumatic Brain Injury
Therapeutic Actions : Hyperbaric Treatment
Pharmacological Actions : Neuroprotective Agents
[+]

Hyperbaric oxygen therapy has the potential to be the first significant treatment in the acute phase of severe traumatic brain injury.Nov 12, 2017

Pubmed Data : J Neurotrauma. 2017 Nov 13. Epub 2017 Nov 13. PMID: 29132229
Article Published Date : Nov 12, 2017
Study Type : Review
Additional Links
Diseases : Traumatic Brain Injury
Therapeutic Actions : Hyperbaric Treatment
Pharmacological Actions : Neuroprotective Agents
[+]

Low level laser treatment may have a role in neurorehabilitation. Dec 01, 2010

Pubmed Data : PM R. 2010 Dec ;2(12 Suppl 2):S292-305. PMID: 21172691
Article Published Date : Dec 01, 2010
Study Type : Review
Additional Links
Diseases : Brain Damage, Head Injuries, Traumatic Brain Injury
Therapeutic Actions : Laser Treatment: Low-Level
[+]

N. sativa and thymoquinone have protective effects against neurodegenerative diseases.Dec 31, 2017

Pubmed Data : CNS Neurol Disord Drug Targets. 2018 07 1. Epub 2018 Jul 1. PMID: 29962349
Article Published Date : Dec 31, 2017
Study Type : Review
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Alzheimer's Disease, Depression, Epilepsy, Ischemia, Neurodegenerative Diseases, Parkinson's Disease, Traumatic Brain Injury
Pharmacological Actions : Antidepressive Agents, Neuroprotective Agents
[+]

Neuroprotective effects of curcumin through autophagy modulation.Dec 04, 2019

Pubmed Data : IUBMB Life. 2019 Dec 5. Epub 2019 Dec 5. PMID: 31804772
Article Published Date : Dec 04, 2019
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Alexander Disease, Alzheimer's Disease, Parkinson's Disease, Stroke: Ischemic, Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
[+]

Piperine attenuates TBI-induced seizures via inhibiting cytokine-activated reactive astrogliosis.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurol. 2020 ;11:431. Epub 2020 Jun 4. PMID: 32655468
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Piperine
Diseases : Seizures, Traumatic Brain Injury
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Resveratrol treatment attenuates the nigrostriatal pathway injury-induced neuronal apoptosis and inflammation.Oct 17, 2016

Pubmed Data : Brain Res. 2016 Oct 18. Epub 2016 Aug 18. PMID: 27769789
Article Published Date : Oct 17, 2016
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Traumatic Brain Injury
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The evidence presented in this paper appears to be supporting the hypothesis that Nigella sativa can enhance learning and memory.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2016 ;2016:6075679. Epub 2016 Feb 28. PMID: 27022403
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Memory Disorders, Neurodegenerative Diseases, Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
[+]

This review discusses the neuroprotective potential of resveratrol in stroke, traumatic brain injury and spinal cord injury.Aug 11, 2015

Pubmed Data : Neurochem Int. 2015 Aug 12. Epub 2015 Aug 12. PMID: 26277384
Article Published Date : Aug 11, 2015
Study Type : Review
Additional Links
Substances : Resveratrol
Diseases : Spinal Cord Injuries, Stroke: Attenuation/Recovery , Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
[+]

Transcranial light-emitting diode therapy could be used for neuropsychological improvement after traumatic brain injury.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Devices (Auckl). 2018 ;11:139-146. Epub 2018 Apr 26. PMID: 29731669
Article Published Date : Dec 31, 2017
Study Type : Review
Additional Links
Diseases : Traumatic Brain Injury
Therapeutic Actions : Light-Emitting Diode Therapy
Pharmacological Actions : Neuroprotective Agents

Copyright: alila / 123RF Stock Photo

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