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Curcumin and L49H37 inhibit pancreatic stellate cells proliferation and induce apoptosis through downregulation of p21 and cell cycle arrest at the G0/G1 phase.

BACKGROUND: Pancreatic cancer is a devastating disease with poor prognosis. It is characterized by a pronounced stromal reaction, which resists chemotherapeutics and effective tumor treatment. Pancreatic stellate cells (PSCs) are mainly responsible for this stromal reaction. Moreover, the cancer and stromal interaction seems to promote tumor prolif...

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