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OBJECTIVE: To assess the incidence of Total Joint Replacement (TJR) during the long-term follow-up of patients with knee osteoarthritis (OA) formerly receiving treatment with glucosamine sulphate or placebo. METHODS: Knee OA patients participating in two previous randomised, placebo-controlled, double-blind, 3-year trials of glucosamine sulphate an...
OBJECTIVE: The aim of this study was to determine whether a herbal remedy made from a subspecies of rose-hip (Rosa canina) might reduce symptoms of osteoarthritis and consumption of rescue medication in patients suffering from osteoarthritis. METHODS: Ninety-four patients with osteoarthritis of the hip or knee were enrolled in a randomized, placebo...
Glucosamine, a naturally occurring amino monosaccharide, is widely used to treat osteoarthritis in humans. Furthermore, glucosamine exhibits an anti-inflammatory action by inhibiting the activation of neutrophils, chondrocytes and synoviocytes. Recently, we revealed that glucosamine suppresses cytokine-induced activation of intestinal epithelial ce...
OBJECTIVE: To evaluate the results of glucosamine hydrochloride in the treatment of knee degenerative osteoarthritis (DOA). METHODS: From February 2006 to January 2007, 60 patients with knee DOA were treated with glucosamine hydrochloride, including 15 males and 45 females. The ages of patients ranged from 41 to 67 years with an average age of 57.5...
OBJECTIVE: Osteoarthritis (OA) is the most common form of arthritis and the second most common cause of long-term disability among middle-aged and older adults in the United States. Methylsulfonylmethane (MSM) is a popular dietary supplement used as a single agent and in combination with other nutrients, and purported to be beneficial for arthritis...
  BACKGROUND: Glucosamine and chondroitin sulfate preparations are widely used as food supplements against osteoarthritis, but critics are skeptical about their efficacy, because of the lack of convincing clinical trials and a reasonable scientific rationale for the use of these nutraceuticals. Most trials were on osteoarthritis of the knee, ...
1: Clin Neurol Neurosurg. 2008 May;110(5):462-5. Epub 2008 Mar 18. Links Impact of the lunar cycle on the incidence of intracranial aneurysm rupture: myth or reality? Ali Y, Rahme R, Matar N, Ibrahim I, Menassa-Moussa L, Maarrawi J, Rizk T, Nohra G, Okais N, Samaha E, Moussa R. Department of Neurosu...
Extracts from the seed of the African shea tree Vitellaria paradoxa C.F. Gaertn have been used traditionally for the treatment of arthritic conditions. However, little is known about the mechanisms by which benefit is conferred. This single-site, 15-week randomized, double-blind, parallel, placebo-controlled study examined a range of biomarkers in ...

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