| Anti-Inflammatory Agents | 41793 | 16644 |  |
| Antioxidants | 36211 | 15133 |  |
| Neuroprotective Agents | 21130 | 8336 |  |
| Tumor Necrosis Factor (TNF) Alpha Inhibitor | 12207 | 5004 |  |
| Antiproliferative | 10352 | 7744 |  |
| Analgesics | 10061 | 1530 |  |
| Apoptotic | 9835 | 7583 |  |
| Interleukin-6 Downregulation | 9794 | 3787 |  |
| Cardioprotective | 9745 | 3050 |  |
| Hypoglycemic Agents | 9634 | 2146 |  |
| Hypolipidemic | 9493 | 2109 |  |
| Hepatoprotective | 9446 | 3997 |  |
| Antidepressive Agents | 8255 | 1538 |  |
| Gastrointestinal Agents | 8078 | 2430 |  |
| Antihypertensive Agents | 7288 | 1060 |  |
| Immunomodulatory | 6825 | 2459 |  |
| Chemopreventive | 6642 | 2196 |  |
| Interleukin-1 beta downregulation | 6377 | 3089 |  |
| NF-kappaB Inhibitor | 6170 | 3583 |  |
| Anti-Apoptotic | 5915 | 3346 |  |
| Anti-Anxiety Agents | 5140 | 845 |  |
| Renoprotective | 4745 | 2063 |  |
| Chemotherapeutic | 4504 | 1665 |  |
| Chemoprotective Agents | 4441 | 1694 | |
| Anti-Bacterial Agents | 4336 | 2054 |  |
| Anticholesteremic Agents | 4137 | 679 |  |
| Nrf2 activation | 3288 | 1878 | |
| Antiviral Agents | 3155 | 1734 |  |
| Malondialdehyde Down-regulation | 3125 | 1019 |  |
| Anti-metastatic | 2938 | 2238 |  |
| Radioprotective | 2642 | 764 |  |
| Superoxide Dismutase Up-regulation | 2545 | 974 |  |
| Anti-Fibrotic | 2350 | 1112 |  |
| Antineoplastic Agents | 2318 | 1534 |  |
| Cyclooxygenase 2 Inhibitors | 2314 | 1356 |  |
| Anticarcinogenic Agents | 2153 | 1019 |  |
| Cell cycle arrest | 2152 | 1745 |  |
| Osteoprotective | 2149 | 731 | |
| Insulin Sensitizers | 2029 | 433 |  |
| Gastroprotective | 1759 | 732 |  |
| Prophylactic Agents | 1752 | 340 | |
| Chemosensitizer | 1710 | 1311 |  |
| Antimicrobial | 1632 | 818 |  |
| MicroRNA modulator | 1566 | 902 | |
| Heme oxygenase-1 up-regulation | 1400 | 819 | |
| Interleukin-10 upregulation | 1388 | 467 |  |
| Anti-Ulcer Agents | 1333 | 354 |  |
| Anticonvulsants | 1185 | 306 |  |
| Matrix metalloproteinase-9 (MMP-9) inhibitor | 1177 | 736 |  |
| Interleukin-8 downregulation | 1163 | 421 |  |
| Antinoceceptive | 981 | 299 |  |
| Matrix metalloproteinase-2 (MMP-2) inhibitor | 956 | 596 |  |
| Vasodilator Agents | 894 | 234 |  |
| Detoxifier | 883 | 265 |  |
| Autophagy Up-regulation | 871 | 581 |  |
| Enzyme Inhibitors | 870 | 403 |  |
| Cytoprotective | 816 | 406 |  |
| Photoprotective | 795 | 313 |  |
| Immunostimulatory | 790 | 242 |  |
| Brain-derived neurotrophic factor modulator | 781 | 295 |  |
| Tumor Suppressor Protein p53 Upregulation | 769 | 563 |  |
| Antifungal Agents | 760 | 431 |  |
| Angiogenesis Inhibitors | 744 | 495 |  |
| Bcl-2 protein down-regulation | 723 | 534 |  |
| Nitric Oxide Inhibitor | 710 | 359 |  |
| Vascular Endothelial Growth Factor Inhibitors | 629 | 341 |  |
| Transforming growth factor beta (TGF-β) inhibitor | 605 | 307 |  |
| Anti-Allergic Agents | 599 | 222 |  |
| Interferon Gamma Reducer | 581 | 217 |  |
| Pancreato Protective Agents | 569 | 309 | |
| Antidiarrheals | 563 | 120 |  |
| Interleukin-17 downregulation | 539 | 202 |  |
| Anti-Asthmatic Agents | 530 | 159 |  |
| Genoprotective | 522 | 203 |  |
| Fertility Agents: Male | 518 | 141 |  |
| Regenerative | 486 | 201 |  |
| Anti-atherogenic | 482 | 162 |  |
| Anxiolytic | 481 | 69 |  |
| Hypotensive | 467 | 63 |  |
| Vasoprotective | 462 | 110 |  |
| Interleukin-4 downregulation | 460 | 173 |  |
| Alpha-glucosidase inhibitor | 427 | 314 |  |
| Catalase Up-Regulation | 424 | 172 |  |
| Anti-Angiogenic | 424 | 286 |  |
| Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor | 404 | 247 | |
| SIRT1 Activator | 400 | 201 |  |
| Postaglandin PGE2 downregulation | 390 | 201 |  |
| Interleukin-18 down-regulation | 385 | 196 |  |
| Radiosensitizer | 379 | 254 |  |
| Interleukin-10 downregulation | 367 | 136 |  |
| Glutathione Upregulation | 367 | 115 |  |
| Anti-Glycation Agents | 353 | 169 | |
| Uricosuric Agents | 342 | 86 |  |
| Dermatologic Agents | 340 | 41 |  |
| Wnt/β-catenin signaling pathway modulation | 335 | 231 | |
| Neurogenesis | 328 | 175 |  |
| Antiparasitic Agents | 325 | 188 |  |
| Nitric Oxide Enhancer | 324 | 90 |  |
| STAT3 Inhibitor | 322 | 216 |  |
| Angiogenesis Inducing Agents | 316 | 155 |  |
| Autophagy Inhibitors | 305 | 191 | |
| Wnt/β-catenin signaling pathway modulation | 300 | 231 | |
| Telomere Protective | 281 | 39 |  |
| Alpha-amylase inhibitor | 279 | 187 |  |
| Cytotoxic | 277 | 238 | |
| Acetylcholinesterase Inhibitor | 262 | 130 |  |
| Fertility Agents: Female | 254 | 54 |  |
| Chondroprotective | 245 | 126 |  |
| Laxative | 243 | 39 |  |
| Immunomodulatory: Th17 downregulation | 243 | 105 |  |
| Matrix metalloproteinase-3 (MMP-3) inhibitor | 241 | 108 |  |
| Adiponectin upregulation | 239 | 42 |  |
| Vascular Endothelial Growth Factor A Inhibitor | 238 | 131 |  |
| Matrix Metalloproteinase-13 (MMP-13) Inhibitor | 233 | 106 |  |
| Neuritogenic | 224 | 108 |  |
| Antimutagenic Agents | 218 | 138 |  |
| Cardiovascular Agents | 215 | 35 |  |
| Platelet Aggregation Inhibitors | 214 | 50 |  |
| P21 Activation | 210 | 146 |  |
| Neuroplasticity enhancement | 207 | 66 | |
| Interleukin-12 downregulation | 205 | 78 |  |
| Transforming growth factor beta (TGF-β) upregulation | 196 | 78 | |
| Prostaglandin PGE2 downregulation | 194 | 89 |  |
| Anti-Adipogenic | 193 | 108 |  |
| Interleukin-4 upregulation | 188 | 73 |  |
| Appetite Suppresant | 187 | 28 |  |
| Osteogenic | 180 | 74 |  |
| Secretagogue | 178 | 38 |  |
| Interleukin-2 Downregulation | 177 | 73 |  |
| Insulin-releasing | 177 | 74 |  |
| Leishmanicidal | 170 | 114 |  |
| Proliferative | 170 | 104 | |
| Heat Shock Protein Inducer | 168 | 59 |  |
| Anti-Tumor | 167 | 78 |  |
| Interleukin-1 alpha downregulation | 166 | 69 |  |
| Antioxidant Effects | 159 | 46 | |
| Anti-HIV Agents | 155 | 96 |  |
| Matrix metalloproteinase-1 (MMP-1) inhibitor | 155 | 92 |  |
| Interleukin-5 downregulation | 154 | 65 |  |
| interleukin-13 down-regulation | 152 | 76 |  |
| Telomerase Upregulation | 149 | 37 |  |
| Cyclin D1 Down-Regulation | 146 | 107 |  |
| Anti-Platelet | 144 | 50 |  |
| Hypnotics and Sedatives | 142 | 58 |  |
| Antispasmodic | 141 | 38 |  |
| Anti-Cachexic Agents | 139 | 51 | |
| Caspase-3 Activation | 137 | 90 |  |
| Glucagon Like peptide 1 (GLP-1) Up-regulation | 131 | 36 |  |
| Angiotensin-Converting Enzyme Inhibitors | 129 | 63 |  |
| Antimalarials | 128 | 80 |  |
| Vascular Cell Adhesion Molecule-1 Inhibitor | 126 | 37 |  |
| Anti-Androgen | 122 | 29 |  |
| Histone deacetylase inhibitor | 119 | 84 |  |
| DNA Repair Up-regulation | 110 | 34 | |
| Interleukin-23 Downregulation | 107 | 42 | |
| Vascular Endothelial Growth Factor Regulator | 106 | 52 |  |
| Cardiotonic Agents | 106 | 10 |  |
| Immunosuppressive Agents | 103 | 52 |  |
| Phase II Detoxification Enzyme Inducer | 100 | 55 |  |
| Xanthine oxidase inhibitor | 100 | 54 |  |
| Calcium Channel Blockers | 98 | 29 |  |
| Telomerase Inhibitor | 98 | 65 |  |
| Wnt/β-catenin pathway down-regulation | 96 | 58 | |
| Epidermal growth factor receptor (EGFR) inhibitor | 96 | 67 |  |
| Quorum Sensing Inhibition | 93 | 87 | |
| Anti-Infective Agents | 92 | 47 |  |
| Antitussive Agents | 92 | 21 |  |
| Bronchodilator Agents | 90 | 17 |  |
| Hypoxia-inducible factor-1 (HIF-1) inhibitor | 89 | 33 |  |
| Insulin-Like Growth Factor Inhibition/Downregulation | 88 | 19 |  |
| Galactogogue | 87 | 11 |  |
| Cyclooxygenase Inhibitors | 86 | 45 |  |
| Cyclooxygenase 1 Inhibitor | 86 | 63 |  |
| Appetite Depressants | 84 | 14 |  |
| Malonaldehyde (MDA) Down-Regulation | 84 | 23 |  |
| Anti-thrombotic | 79 | 34 |  |
| Anti-pyretic | 76 | 33 |  |
| Tumor Necrosis Factor (TNF) Alpha Enhancer | 75 | 27 |  |
| Estrogen Receptor Modulators | 75 | 40 |  |
| NF-E2-Related Factor-2 (Nrf2) Modulator | 74 | 42 |  |
| Iron Chelating Agents | 74 | 25 |  |
| Neurorestorative | 71 | 21 |  |
| Caspase-9 Activation | 71 | 47 |  |
| Anti-Proliferative | 68 | 56 |  |
| Aphrodisiac | 68 | 23 |  |
| Adiponectin Down-Regulation | 68 | 11 |  |
| Multidrug Resistance Gene Modulators | 67 | 57 | |
| Interferon-gamma (IFN-gamma) inducer | 65 | 21 |  |
| Heme oxygenase-1 inducer | 63 | 43 | |
| Ergogenic | 63 | 8 | |
| Antiemetics | 62 | 6 | |
| Proteasome Inhibitors | 61 | 42 |  |
| Antiprotozoal Agents | 61 | 32 |  |
| Bax/Bcl2 ratio: Increase | 61 | 45 |  |
| GABA Modulators | 57 | 24 |  |
| Thermogenic | 57 | 9 | |
| Diuretics | 57 | 15 |  |
| Serotonergic | 56 | 12 |  |
| Enzyme Inhibitors: Pancreatic Lipase | 54 | 25 |  |
| Cholagogues and Choleretics | 54 | 12 |  |
| Photosensitizing Agents | 53 | 25 |  |
| Aromatase Inhibitors | 53 | 36 |  |
| Fibroblast growth factor 21 upregulation | 52 | 22 | |
| Chelating Agents | 52 | 27 |  |
| Lipolytic | 51 | 19 |  |
| Anti-Retroviral Agents | 51 | 20 |  |
| 5-alpha reductase inhibitor | 51 | 18 |  |
| Interleukin-2 upregulation | 51 | 13 |  |
| Lipoxygenase Inhibitors | 50 | 27 |  |
| Heat Shock Protein Down-Regulation | 50 | 29 |  |
| Survivin Down-Regulation | 50 | 44 |  |
| Interleukin-12 upregulation | 49 | 14 |  |
| Reverse Transcriptase Inhibitors | 49 | 31 |  |
| 5-Lipoxygenase Inhibitor | 49 | 32 |  |
| Insecticidal | 46 | 24 | |
| 5-Lipoxygenase Inhibitor | 46 | 32 | |
| Anabolic Agents | 45 | 12 |  |
| Histamine Antagonists | 45 | 17 |  |
| Histamine Antagonists | 45 | 17 |  |
| Enzyme Activators | 42 | 26 |  |
| Acid Blockers | 42 | 17 |  |
| Carcinogens | 42 | 6 | |
| Bcl-xL down-regulation | 41 | 30 | |
| Interferon Inducers | 41 | 10 |  |
| Antiurolithiatic | 40 | 13 |  |
| Drug synergy | 40 | 11 |  |
| Interleukin-22 Downregulation | 40 | 20 | |
| Neuromodulatory | 39 | 9 | |
| Appetite Stimulants | 39 | 8 | |
| Proton Pump Inhibitor | 38 | 14 |  |
| Cholinesterase Inhibitors | 38 | 28 |  |
| Leukotriene Antagonists | 38 | 9 | |
| Insulin Down-Regulation | 38 | 7 | |
| Glucagon Like Peptide 1 (GLP-1) Down-Regulation | 37 | 7 | |
| Ghrelin Down-Regulation | 36 | 6 | |
| Interleukin-8 upregulation | 35 | 5 | |
| Analgesics: Non-Narcotic | 35 | 10 |  |
| Antimycobacterial | 35 | 19 |  |
| Uterotonic | 34 | 11 |  |
| Spermatogenic | 34 | 12 |  |
| Cholecystokinin (CCK) Up-regulation | 34 | 6 | |
| Antipsychotic Agents | 34 | 15 |  |
| HIV Protease Inhibitors | 33 | 21 |  |
| Bax/Bcl2 Ratio: Decrease | 33 | 21 |  |
| Interleukin-6 upregulation | 33 | 12 |  |
| Matrix Metalloproteinase-7 (MMP-7) Inhibitor | 32 | 21 |  |
| Aldose reductase inhibitor | 32 | 9 | |
| Dopaminergic | 32 | 10 |  |
| Caspase-8 activation | 32 | 22 |  |
| Protein Kinase Inhibitors | 32 | 21 |  |
| Matrix metalloproteinase-8 (MMP-8) inhibitor | 30 | 12 | |
| Nootropic Agents | 30 | 18 |  |
| STAT3 Activation | 29 | 20 | |
| Fibrinolytic Agents | 28 | 7 | |
| Androgen Antagonists | 27 | 6 | |
| Prostaglandin Antagonists | 27 | 13 |  |
| Vascular Endothelial Growth Factor C Inhibitor | 27 | 10 | |
| Glucose Uptake Optimization | 26 | 9 | |
| Interleukin-17 upregulation | 26 | 5 | |
| Leptin Down-Regulation | 26 | 9 | |
| Fertility Agents | 25 | 10 |  |
| Neurominidase Inhibitor | 25 | 24 |  |
| Detoxifier: Radionuclide Removal | 25 | 5 | |
| Remyelination | 24 | 13 |  |
| Topoisomerase II Inhibitor | 23 | 21 |  |
| Natriuretic Agents | 23 | 4 | |
| Anti-cancer | 23 | 6 | |
| Monocyte chemotattractant protein-1 (MCP-1) Inhibitor | 23 | 4 | |
| Anticoagulants | 22 | 18 |  |
| Endothelin-1 Inhibitor | 22 | 3 | |
| Viral Hemagglutinin Inhibitor | 22 | 16 |  |
| Matrix Metalloproteinase-12 (MMP-12) Inhibitor | 21 | 12 | |
| Gluconeogenesis Inhibitor | 21 | 15 |  |
| Interleukin-18 upregulation | 20 | 11 |  |
| Adenosine deaminase inhibitor | 20 | 7 | |
| Fatty Acid Oxidation | 20 | 2 | |
| Cholecystokinin Releaser | 20 | 2 | |
| Hematopoietic | 20 | 9 | |
| Insect Repellents | 19 | 12 |  |
| Protease Inhibitors | 19 | 10 |  |
| Tyrosinase inhibitors | 19 | 18 |  |
| P38 Mitogen-Activated Protein Kinase Modulator | 18 | 12 |  |
| Oncogene Suppressor | 18 | 14 |  |
| Immune Enhancing Properties | 18 | 5 | |
| Adenosine Monophosphate (AMP)-activated Protein Kinase (AMPK | 18 | 4 | |
| Gene Protective | 18 | 6 | |
| Antithrombotic | 17 | 6 | |
| Anticholinergic | 17 | 5 | |
| Topoisomerase I inhibitor | 17 | 15 |  |
| Glucose transporter-1 (GLUT1) expression down-regulation | 16 | 8 | |
| Monoamine Oxidase Inhibitors | 16 | 5 | |
| Peptide YY (PYY) Up-Regulation | 16 | 4 | |
| Interleukin-21 downregulation | 16 | 4 | |
| Antitubercular Agents | 15 | 5 | |
| Hepatocyte growth factor (HGF) inhibitor | 15 | 4 | |
| Antilipemic Agents | 15 | 2 | |
| Antipruritics | 15 | 4 | |
| Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor | 15 | 10 |  |
| Interleukin-1 beta upregulation | 15 | 5 | |
| Contraceptive Agents: Male | 14 | 3 | |
| Teratogens | 14 | 3 | |
| Cell Differentiation Inducer | 14 | 11 |  |
| Neocardiogenic | 14 | 11 |  |
| Neocardiogenic | 14 | 11 |  |
| Glutathione S-transferase Inhibitor | 14 | 4 | |
| Paraptosis | 14 | 14 | |
| 15-Lipoxygenase (15-LOX) Inhibitor | 13 | 9 | |
| Phase I Detoxification Enzyme Inducer | 13 | 7 | |
| Beta-Defensin-2 Up-Regulation | 13 | 3 | |
| Anti-collagenase | 13 | 3 | |
| Glutathione Peroxidase 1 (GPx1) Up-Regulation | 13 | 7 | |
| Vascular Endothelial Growth Factor A Enhancer | 13 | 7 | |
| Muscle Relaxants: Central | 13 | 4 | |
| Leukotriene B4 downregulation | 13 | 4 | |
| Carminative | 12 | 2 | |
| Insulin Receptor Modulator | 12 | 2 | |
| Dopamine Agents | 12 | 2 | |
| Mucolytic | 12 | 2 | |
| Endocannabinoid down-regulation | 12 | 2 | |
| Immunomodulatory: Innate Immunity Up-Regulation | 12 | 2 | |
| Mitogen-activated protein kinase inhibitors | 12 | 3 | |
| Anti-edemic | 12 | 2 | |
| Vasopressin Inhibitor | 12 | 2 | |
| Immunomodulatory: T-Cell down-regulation | 12 | 2 | |
| VEGFR3 inhibition | 12 | 3 | |
| Disinfectants | 12 | 3 | |
| Interleukin-13 Up-Regulation | 12 | 3 | |
| Metallothionein Up-regulation | 12 | 2 | |
| Interleukin-1 receptor antagonist | 11 | 2 | |
| PI3K/Akt/signaling suppression | 11 | 6 | |
| Matrix Metalloproteinase-8 Inhibitor | 11 | 2 | |
| Mitogen-activated protein kinase kinase 4 (MEK4) | 11 | 2 | |
| Adrenergic alpha-Antagonists | 11 | 2 | |
| Histamine down-regulation | 11 | 9 | |
| P16 Activation | 11 | 2 | |
| Tocolytic Agents | 11 | 2 | |
| Insulinotrophic | 11 | 7 | |
| Immunomodulatory: Immunoglobulin G up-regulation | 10 | 1 | |
| NOX2 inhibitor | 10 | 1 | |
| Immunomodulatory: Immunoglobulin M Up-Regulation | 10 | 1 | |
| Mitochondrial Superoxide Dismutase Upregulation | 10 | 6 | |
| Interleukin-3 upregulation | 10 | 1 | |
| Glutathione peroxidase 1 (GPx1) inhibitors | 10 | 1 | |
| Estrogens | 10 | 1 | |
| Intracellular adhesion molecule down-regulation | 10 | 1 | |
| Gastric Inhibitory Polypeptide Up-Regulation | 10 | 1 | |
| CYP3A enzyme induction | 10 | 1 | |
| Oxytocin inducer | 10 | 1 | |
| Interleukin 1 receptor antagonist (IL-1Ra) up-regulation | 10 | 1 | |
| Central Nervous System Depressants | 10 | 1 | |
| Diacylglyceride acyltransferase 1 (DGAT1) Inhibition | 10 | 1 | |
| Respiratory System Agents | 10 | 1 | |
| Peptide YY (PYY) Down-regulation | 10 | 1 | |
| Matrix Metalloproteinases Inhibitors | 10 | 6 | |
| Neurotransmitter Uptake Inhibitors | 10 | 1 | |
| Phosphorylase Kinase Inhibitors | 10 | 1 | |
| Glucose transporter-2 (GLUT2) expression down-regulation | 10 | 6 | |
| Drug sparing | 10 | 1 | |
| Androgens | 10 | 1 | |
| Immunomodulatory: CD23+ Mature Macrophage Down-Regulation | 10 | 1 | |
| Insulin Antagonists | 10 | 1 | |
| Hormones | 10 | 1 | |
| cAMP up-regulation | 10 | 1 | |
| Glucose transporter-2 (GLUT2) expression up-regulation | 10 | 1 | |
| PER2 Protein Expression Up-regulation | 10 | 1 | |
| Immunostimulatory: IgA Production Up-Regulation | 10 | 1 | |
| Isoprostane Down-Regulation | 10 | 1 | |
| Redox Modulator | 9 | 5 | |
| Cannabinoid Receptor Antagonist/Inverse Agonist | 9 | 7 | |
| Excitatory Amino Acid Agonists | 9 | 5 | |
| Analgesics: Opioid | 9 | 6 | |
| Insulin-mimetic | 9 | 6 | |
| Selective estrogen enzyme modulator (SEEM) | 9 | 7 | |
| Caspase-7 Activation | 9 | 7 | |
| Prostaglandin E Synthase-1 (PGES-1) Down-Regulation | 9 | 3 | |
| NADPH Oxidase Inhibitors | 8 | 4 | |
| Acetylcholinesterase Down-Regulation | 8 | 5 | |
| Benzodiazepine receptor agonist | 8 | 6 | |
| Angiogenesis Modulating Agents | 8 | 5 | |
| Thrombolytic | 8 | 5 | |
| Enzyme Inhibitors: Pancreatic Amylase | 8 | 6 | |
| Selective Estrogen Receptor Modulators | 8 | 5 | |
| Monoaminergic | 8 | 4 | |
| Vascular Endothelial Growth Factor D Inhibitor | 8 | 4 | |
| ER beta receptor up-regulation | 7 | 5 | |
| Insulin-Like Growth Factor Enhancer/Upregulation | 7 | 4 | |
| Intracellular adhesion molecule-1 (ICAM-1) | 7 | 5 | |
| Chemotherapeuticm | 7 | 5 | |
| Antigiardial agents | 7 | 4 | |
| Tyrosinase Inhibition | 7 | 5 | |
| HER-2 oncoprotein down-regulation | 7 | 2 | |
| E-cadherin down-regulation | 6 | 5 | |
| AMP-activated protein kinase modulation | 6 | 4 | |
| TRAIL sensitizer | 6 | 5 | |
| AKT-mammalian target of rapamycin (mTOR) pathway inhibitor | 6 | 5 | |
| PI3K-AKT inhibitor | 6 | 4 | |
| Bone Density Conservation Agents | 6 | 3 | |
| Caspase-3 Inhibition | 6 | 4 | |
| Anti-Arrhythmia Agents | 6 | 4 | |
| Anti-Estrogenic | 6 | 4 | |
| Chemokine (C-C motif) Ligand 2 (CCL2) Down-Regulation | 6 | 4 | |
| Trypanocidal Agents | 6 | 5 | |
| Trypsin Inhibitors | 6 | 4 | |
| Cholinergic Agents | 5 | 3 | |
| Protein tyrosine phosphatase 1B (PTP1B) modulator | 5 | 3 | |
| Cryoprotective Agents | 5 | 4 | |
| HIV Fusion Inhibitors | 5 | 4 | |
| Lactate Dehydrogenase A Inhibitor | 5 | 3 | |
| Vascular smooth muscle cell (VSMC) inhibitor | 5 | 5 | |
| Spermicidal Activity | 5 | 1 | |
| Inhibitor of Nuclear Factor Kappa-B Kinase (IKK) | 5 | 4 | |
| Angiotensin II Type 1 Receptor Blockers | 5 | 3 | |
| Thromboxane (TXB) Inhibitors | 5 | 4 | |
| Extracellular Signal-Regulated Kinases Modulator | 5 | 4 | |
| Antacids | 5 | 3 | |
| HMG-CoA reductase inhibitor | 5 | 4 | |
| Interleukin-15 downregulation | 5 | 3 | |
| Dental Disinfectants | 4 | 1 | |
| Vitamin D Receptor (VDR) Modulator | 4 | 3 | |
| Peroxisome Proliferators | 4 | 2 | |
| Ghrelin Up-regulation | 4 | 2 | |
| Histamine Agents | 4 | 3 | |
| Schistosomicides | 4 | 2 | |
| Tumor Necrosis Factor (TNF) Alpha Upregulation | 4 | 2 | |
| Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Upregulation | 4 | 2 | |
| Scolicidal | 4 | 4 | |
| C-Jun N-Terminal Kinases (JNK) Modulator | 4 | 3 | |
| Antiparkinson Agents | 4 | 2 | |
| Paraoxonase down-regulation | 4 | 2 | |
| Beta-Endorphin Enhancer | 4 | 2 | |
| Immunomodulatory: Regulatory T Cell Up-Regulation | 4 | 2 | |
| Tumor Suppressor Protein p73 Upregulation | 4 | 3 | |
| Adrenergic alpha-Agonists | 4 | 3 | |
| SGLT1 inducer | 4 | 2 | |
| Erythropoietic | 4 | 3 | |
| Anti-Inflammatory Agents: Non-Steroidal | 4 | 2 | |
| Radiation-Protective Agents | 4 | 2 | |
| SGLT1 inducer | 4 | 2 | |
| Cyclin-dependent kinase inhibitor: P16INK4 | 4 | 3 | |
| Metal Chelation: Copper | 4 | 3 | |
| 12-lipoxygenase (12-LOX) Inhibitor | 3 | 2 | |
| Estrogen Receptor Agonist | 3 | 3 | |
| Cholinergic Antagonists | 3 | 2 | |
| NF-kappa-B-inducing kinase (NIK) modulator | 3 | 2 | |
| Vanilloid Receptor-1 Modulator | 3 | 3 | |
| Antimitotic Agents | 3 | 3 | |
| Atrial Natriuretic Factor Modulation | 3 | 2 | |
| Anti-Infective Agents: Urinary | 3 | 2 | |
| Quinone Reductase-Inducer | 3 | 2 | |
| HIV-1 Integrase Inhibitor | 3 | 3 | |
| Expectorants | 3 | 2 | |
| Cyclin-Dependent Kinase Inhibitor | 3 | 3 | |
| P-glycoprotein Inhibitors | 3 | 3 | |
| Survival protein down-regulation | 3 | 2 | |
| Matrix metalloproteinase-14 (MMP-14) inhibitor | 3 | 3 | |
| Platelet aggregation inhibitor: collagen-induced aggregation | 3 | 2 | |
| Estradiol 3-glucuronide enhancer | 3 | 3 | |
| Insecticides | 3 | 2 | |
| Interleukin-1 alpha upregulation | 3 | 2 | |
| Adrenergic beta-Agonists | 3 | 2 | |
| Estradiol Antagonists | 3 | 2 | |
| Fatty Acid Synthesis Inhibitors | 3 | 3 | |
| Forkhead Transcription Factor Family O (FOXO) Modulator | 3 | 2 | |
| Contraceptive Agents | 3 | 2 | |
| Histamine up-regulation | 3 | 2 | |
| p300/NF-κB down-regulation | 3 | 3 | |
| Steroidogenesis | 3 | 2 | |
| Intercellular adhesion molecule 3 down-regulation | 3 | 2 | |
| Breast cancer resistance protein (BCRP) down-regulation | 2 | 2 | |
| PPAR-Gamma Up-Regulation | 2 | 2 | |
| Antidiuretic Agents | 2 | 1 | |
| Abortifacient Agents | 2 | 1 | |
| Akt-dependent HO-1 expression up-regulation | 2 | 1 | |
| High-mobility group box-1 (HMGB1) inhibitor | 2 | 1 | |
| Sarcoplasmic Calcium ATPase Up-regulation | 2 | 1 | |
| Ovogenic | 2 | 1 | |
| Spasmogenic | 2 | 1 | |
| Arylesterase down-regulation | 2 | 1 | |
| Stomachic | 2 | 1 | |
| JAM3 gene down-regulation | 2 | 1 | |
| Bronchoconstrictor Agents | 2 | 1 | |
| Adjuvants: Immunologic | 2 | 1 | |
| Serotonin Agents | 2 | 1 | |
| Incretin Modulator | 2 | 1 | |
| Hydroperoxidase Inhibitor | 2 | 1 | |
| Carbonic Anhydrase Inhibitors | 2 | 1 | |
| Progestagenic | 2 | 1 | |
| Antifibrinolytic Agents | 2 | 2 | |
| CYP1A1 Transcription Inhibitor | 2 | 1 | |
| Adrenergic Agents | 2 | 1 | |
| Histamine Agonists | 2 | 1 | |
| Serotonin Agonists | 2 | 1 | |
| Enzyme Inhibitors: Maltase Inhibition | 2 | 1 | |
| Phase I Detoxification Enzyme Inhibitor | 2 | 1 | |
| Lipotropic Agents | 2 | 1 | |
| Central Nervous System Agents | 2 | 1 | |
| Progesterone receptor (PR) up-regulation | 2 | 1 | |
| Prostaglandin PGF2 downregulation | 2 | 2 | |
| GSH-Px Up-Regulation | 2 | 1 | |
| RANTES (CCL5) Inhibitor | 2 | 2 | |
| Adrenergic Agonists | 2 | 2 | |
| Serum ceruloplasmin oxidase reducer | 2 | 1 | |
| Muscarinic Agonists | 2 | 1 | |
| Opioid Endogenous Up-regulation | 2 | 1 | |
| Phosphodiesterase Inhibitors | 2 | 2 | |
| Reactive Oxygen Species (ROS) attenuation | 2 | 2 | |
| Muscarinic Antagonists | 2 | 2 | |
| Lymphagogue | 2 | 1 | |
| Immunologic Factors | 2 | 1 | |
| Anti-elastase | 2 | 2 | |
| Thromboxane B2 Inhibitor | 2 | 2 | |
| Calcium Desensitizer | 2 | 1 | |
| Follicle-stimulating hormone receptor (FSHR) up-regulation | 2 | 1 | |
| Cicatrizing | 2 | 1 | |
| Cyclin-Dependent Kinase Inhibitor: P16 | 2 | 2 | |
| Receptor activator of NF-κB (RANK) gene expression | 2 | 2 | |
| Interleukin-5 upregulation | 2 | 1 | |
| Food Preservatives | 2 | 2 | |
| Coccidiostats | 2 | 1 | |
| 1-Glutamine Uptake Inhibitor | 2 | 2 | |
| Glycine Agents | 2 | 1 | |
| Adenosine Monophosphate (AMP)-Activated Protein Kinase (AMPK) Down-Regulation | 2 | 1 | |
| Receptor-Related Orphan Receptor (ROR)-Alpha1 Inhibitor | 2 | 1 | |
| Antinitrosation | 2 | 1 | |
| β(2)-adrenoceptor up-regulation | 2 | 1 | |
| Alpha-hemolysin inhibitor | 2 | 2 | |
| Histamine H2 Antagonists | 2 | 2 | |
| Sigma-1 Receptor Agonist | 2 | 2 | |
| Arginine Vasopressin (AVP) up-regulation. | 2 | 1 | |
| Anthelmintics | 2 | 1 | |
| Stearoyl coenzyme A desaturase-1 modulator | 2 | 1 | |
| Myorelaxant | 2 | 1 | |
| Neutrophil Activation: Down-Regulation | 2 | 1 |  |
| BRCA-1 Downregulation | 2 | 2 | |
| Uncoupling Agents | 2 | 1 | |
| Antilipolytic | 2 | 2 | |
| Death receptor up-regulation | 2 | 1 | |
| Redox Balancer | 2 | 1 | |
| β-secretase Inhibitor | 2 | 2 | |
| Environmental Pollutants | 2 | 1 | |
| Anesthetics | 2 | 1 | |
| ER alpha receptor up-regulation | 2 | 1 | |
| Immunomodulatory: CD8+ Up-regulation | 2 | 1 | |
| Myosin heavy chain alpha (MHCalpha) reducer | 2 | 1 | |
| Neutrophil Rolling Inhibitor | 2 | 1 | |
| Noradrenergic | 2 | 1 | |
| Human androgen receptor (AR) antagonist | 2 | 2 | |
| Leukotriene C4 Downregulation | 2 | 2 | |
| Cancerous inhibitor of protein phosphatase 2A inhibitor | 1 | 1 | |
| Free Radical Scavengers | 1 | 1 | |
| Prostaglandin H Synthase-1 (PGHS-1) Inhibits | 1 | 1 | |
| Glucose transporter-5 (GLUT5) expression down-regulation | 1 | 1 | |
| Glyoxalase 1 inhibitor | 1 | 1 | |
| Mast Cell Activation Inhibitor | 1 | 1 | |
| mTOR/S6K pathway Activator | 1 | 1 | |
| Human Polymorphonuclear Leukocyte Degranulation Inhibitor | 1 | 1 | |
| Leukotriene D4 antagonist | 1 | 1 | |
| PRL-3 Down-Regulation | 1 | 1 | |
| Anti-Psychotic | 1 | 1 | |
| Prostaglandin H Synthase-2 (PGHS-2) Up-Regulation | 1 | 1 | |
| Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Inhibitor | 1 | 1 | |
| Emmenagogue | 1 | 1 | |
| Oxidants | 1 | 1 | |
| Astringents | 1 | 1 | |
| Palmitoylation Inhibitors | 1 | 1 | |
| Caspase-14 Upregulation | 1 | 1 | |
| Sulfonation | 1 | 1 | |
| Chemosterilants | 1 | 1 | |
| 17beta-hydroxysteroid dehydrogenase inhibitor | 1 | 1 | |
| Psychedelic | 1 | 1 | |
| RANK Downregulation | 1 | 1 | |
| Hemolytic Agents | 1 | 1 | |
| Dopamine Agonists | 1 | 1 | |
| Akt-SREBP-1 activater | 1 | 1 | |
| Oxytocics | 1 | 1 | |
| Erk/MAP Inactivation | 1 | 1 | |
| Caspase-2 Activation | 1 | 1 | |
| Hydroxyheptadecatrienoate (HHT) Inhibitor | 1 | 1 | |
| IGF-1R expression down-regulation | 1 | 1 | |
| Carbonyl Reductase 1Inhibitor | 1 | 1 | |
| Cyclin-Dependent Kinase 4 Down-Regulation | 1 | 1 | |
| Dopamine Antagonists | 1 | 1 | |
| Endocannabinoid Modulator | 1 | 1 | |
| Eryptotic | 1 | 1 | |
| Superoxide Scavenger | 1 | 1 | |
| PKM2 downregulation | 1 | 1 | |
| Transient Receptor Potential Melastatin 2 Inhibition | 1 | 1 | |
| Chymotrypsin Inhibitor | 1 | 1 | |
| 5-HTergic | 1 | 1 | |
| Dopamine Receptor D3 Antagonist | 1 | 1 | |
| Secretagogues: Prolactin Up-Regulation | 1 | 1 | |
| Molecular Probes | 1 | 1 | |
| Neovasculogenesis | 1 | 1 | |
| Ionophores | 1 | 1 | |
| Brain-Associated Sulfotransferase Down-Regulation | 1 | 1 | |
| Phospholipase D Inhibitors | 1 | 1 | |
| Transient receptor potential vanilloid type-2 activation | 1 | 1 | |
| 5-Hydroxyeicosatetraenoic acid (5-HETE) Inhibitor | 1 | 1 | |
| Dipeptidyl-Peptidase IV Inhibitors | 1 | 1 | |
| Zinc-dependent metalloproteinase inhibitor | 1 | 1 | |
| Enkephalinase inhibitor | 1 | 1 | |
| Arginase 1 (Arg1) up-regulation | 1 | 1 | |
| EpCAM surface marker down-regulation | 1 | 1 | |
| STAT3-NFκB Signaling: downregulation | 1 | 1 | |
| Matrix metalloproteinase-16 (MMP-16) inhibitor | 1 | 1 | |
| Nonpeptidyl Inhibitors | 1 | 1 | |
| IRAK-MAPK Modulator | 1 | 1 | |
| Calcium/calmodulin dependent protein kinase II inhibitor | 1 | 1 | |
| Protein Kinase C Inhibitor | 1 | 1 | |
| Antidepressive Agents: Second-Generation | 1 | 1 | |
| Radiation-Sensitizing Agents | 1 | 1 | |
| Cytotoxins | 1 | 1 | |
| Hematologic Agents | 1 | 1 | |
| Ribonucleotide Reductase Inhibitor | 1 | 1 | |
| Enoyl-acyl Carrier Protein (ACP) Reductase Inhibitors | 1 | 1 | |
| Matrix metalloproteinase-17 (MMP-17) inhibitor | 1 | 1 | |
| Hypomethylating | 1 | 1 | |
| Phosphorylated Rb Down-Regulation | 1 | 1 | |
| Antibiotics: Antifungal | 1 | 1 | |
| 1-Leucine Uptake Inhibitor | 1 | 1 | |
| Radiopharmaceuticals | 1 | 1 | |
| Air Pollutants: Radioactive | 1 | 1 | |
| Herbicides | 1 | 1 | |
| S-phase kinase associated protein 2 inhibition | 1 | 1 | |
| Aminopeptidase N (APN/CD13) inhibitor | 1 | 1 | |
| Serine Proteinase Inhibitors | 1 | 1 | |
| Apaf-1/caspase-dependent apoptotic pathway activator | 1 | 1 | |
| Estrogen Antagonists | 1 | 1 | |
| Neuroimmunomodulation | 1 | 1 |  |
| Maspin (Protease Inhibitor) Up-Regulation | 1 | 1 | |
| Hepatoma-derived growth factor (HDGF) inhibitor | 0 | 1 | |