Natural Health Research Discovery

Each Topic is an Index of Curated Biomedical Research Abstracts

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Pharmacological Actions

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Pharmacological Actions (501)

ALLA B C D E F G H I J L M N O P Q R S T U V W X Z Β
Pharmacological Action NameCumulative Knowledgesort iconAbstractsPDF
Antioxidants215288856Downloadable Document
Anti-Inflammatory Agents208598334Downloadable Document
Neuroprotective Agents104044396Downloadable Document
Apoptotic69865304Downloadable Document
Antiproliferative68015032Downloadable Document
Tumor Necrosis Factor (TNF) Alpha Inhibitor67362815Downloadable Document
Cardioprotective53771675Downloadable Document
Chemopreventive53741717Downloadable Document
Hypoglycemic Agents53661338Downloadable Document
Hypolipidemic53581221Downloadable Document
Hepatoprotective50982264Downloadable Document
Interleukin-6 Downregulation50291994Downloadable Document
Antidepressive Agents4882874Downloadable Document
Antihypertensive Agents4527683Downloadable Document
Immunomodulatory40481475Downloadable Document
NF-kappaB Inhibitor35362098Downloadable Document
Analgesics3498646Downloadable Document
Gastrointestinal Agents3145843
Anticholesteremic Agents3078530Downloadable Document
Interleukin-1 beta downregulation30411567Downloadable Document
Anti-Anxiety Agents2913487
Anti-Apoptotic29051672Downloadable Document
Anti-Bacterial Agents28941251Downloadable Document
Renoprotective24041075Downloadable Document
Chemotherapeutic23281086
Chemoprotective Agents2322906
Malondialdehyde Down-regulation2065678Downloadable Document
Anti-metastatic19721481Downloadable Document
Antiviral Agents19571034Downloadable Document
Anticarcinogenic Agents1890889Downloadable Document
Antineoplastic Agents18471170Downloadable Document
Cell cycle arrest16781348Downloadable Document
Radioprotective1668521Downloadable Document
Cyclooxygenase 2 Inhibitors1589926Downloadable Document
Nrf2 activation1584916
Superoxide Dismutase Up-regulation1403551Downloadable Document
Antimicrobial1209582Downloadable Document
Insulin Sensitizers1185244Downloadable Document
Chemosensitizer1124854Downloadable Document
MicroRNA modulator1023618
Osteoprotective971351
Gastroprotective955388Downloadable Document
Anti-Fibrotic924463Downloadable Document
Matrix metalloproteinase-9 (MMP-9) inhibitor786505Downloadable Document
Prophylactic Agents780182
Matrix metalloproteinase-2 (MMP-2) inhibitor727442Downloadable Document
Enzyme Inhibitors692347Downloadable Document
Anticonvulsants678189Downloadable Document
Cytoprotective659326
Antinoceceptive647197Downloadable Document
Detoxifier644202Downloadable Document
Immunostimulatory633192Downloadable Document
Vasodilator Agents626169Downloadable Document
Heme oxygenase-1 up-regulation624373
Tumor Suppressor Protein p53 Upregulation585431Downloadable Document
Interleukin-8 downregulation581231Downloadable Document
Bcl-2 protein down-regulation553407Downloadable Document
Anti-Ulcer Agents523184Downloadable Document
Autophagy Up-regulation518349Downloadable Document
Nitric Oxide Inhibitor498258Downloadable Document
Antifungal Agents494306Downloadable Document
Angiogenesis Inhibitors488296
Genoprotective477177Downloadable Document
Anxiolytic47566Downloadable Document
Hypotensive46763Downloadable Document
Brain-derived neurotrophic factor modulator458166
Photoprotective446198
Anti-Allergic Agents442150Downloadable Document
Antidiarrheals43987
Vascular Endothelial Growth Factor Inhibitors435247
Regenerative408172
Pancreato Protective Agents358194
Interleukin-4 downregulation355128Downloadable Document
Anti-atherogenic348120
Anti-Angiogenic347234Downloadable Document
Interleukin-10 downregulation335128Downloadable Document
Glutathione Upregulation29996Downloadable Document
Radiosensitizer291182Downloadable Document
Anti-Asthmatic Agents28671
Alpha-glucosidase inhibitor274201Downloadable Document
Dermatologic Agents27232Downloadable Document
Catalase Up-Regulation264112
Nitric Oxide Enhancer26176Downloadable Document
Telomere Protective23129
Adiponectin upregulation21739
Neurogenesis215109
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor214142
Antiparasitic Agents208121Downloadable Document
Wnt/β-catenin signaling pathway modulation208149
Vasoprotective20752
Uricosuric Agents20544
Transforming growth factor beta (TGF-β) inhibitor203106
Postaglandin PGE2 downregulation202110
Cardiovascular Agents20132Downloadable Document
Platelet Aggregation Inhibitors20045Downloadable Document
Anti-Glycation Agents197100
Prostaglandin PGE2 downregulation19388Downloadable Document
Interleukin-17 downregulation19385
Neuritogenic18589Downloadable Document
Vascular Endothelial Growth Factor A Inhibitor17997Downloadable Document
Secretagogue17838Downloadable Document
Immunomodulatory: Th17 downregulation17781
Alpha-amylase inhibitor175110
Autophagy Inhibitors175115
Acetylcholinesterase Inhibitor17095Downloadable Document
Matrix metalloproteinase-3 (MMP-3) inhibitor16968
Anti-Adipogenic16485Downloadable Document
Antimutagenic Agents16499Downloadable Document
P21 Activation160119
Anti-Tumor15476Downloadable Document
Matrix Metalloproteinase-13 (MMP-13) Inhibitor14566
Antispasmodic14037Downloadable Document
Interleukin-12 downregulation13953
Caspase-3 Activation13790Downloadable Document
Telomerase Upregulation13734Downloadable Document
Anti-Platelet13747Downloadable Document
Anti-HIV Agents13384Downloadable Document
Interleukin-18 down-regulation13261
Glucagon Like peptide 1 (GLP-1) Up-regulation12935Downloadable Document
Heat Shock Protein Inducer12648Downloadable Document
Interleukin-2 Downregulation12351
Vascular Cell Adhesion Molecule-1 Inhibitor12334Downloadable Document
Insulin-releasing12249Downloadable Document
Interleukin-5 downregulation12049
Leishmanicidal11879Downloadable Document
Interleukin-4 upregulation11342
Cyclin D1 Down-Regulation10679
Cardiotonic Agents10610
Interleukin-10 upregulation10524
Anti-Androgen10423Downloadable Document
Interleukin-1 alpha downregulation10242Downloadable Document
Matrix metalloproteinase-1 (MMP-1) inhibitor9959
Angiotensin-Converting Enzyme Inhibitors9954Downloadable Document
Calcium Channel Blockers9829Downloadable Document
Histone deacetylase inhibitor9869Downloadable Document
Phase II Detoxification Enzyme Inducer9552Downloadable Document
Telomerase Inhibitor9562Downloadable Document
DNA Repair Up-regulation9327
Fertility Agents: Female9018
interleukin-13 down-regulation9047
Antimalarials9053Downloadable Document
Angiogenesis Inducing Agents8845
Epidermal growth factor receptor (EGFR) inhibitor8760Downloadable Document
Insulin-Like Growth Factor Inhibition/Downregulation8618Downloadable Document
Wnt/β-catenin pathway down-regulation8648
Neuroplasticity enhancement8323
Immunosuppressive Agents8043Downloadable Document
Anti-Cachexic Agents7926
Bronchodilator Agents7815Downloadable Document
Anti-thrombotic7632Downloadable Document
Cytotoxic7660
Cyclooxygenase Inhibitors7442Downloadable Document
Galactogogue738
Neurorestorative7121Downloadable Document
Caspase-9 Activation7046
NF-E2-Related Factor-2 (Nrf2) Modulator6939
Xanthine oxidase inhibitor6934Downloadable Document
Anti-Proliferative6755Downloadable Document
Aphrodisiac6722Downloadable Document
Anti-Infective Agents6640
Cyclooxygenase 1 Inhibitor6548Downloadable Document
Appetite Suppresant6414
Ergogenic638
Malonaldehyde (MDA) Down-Regulation6215
Anti-pyretic6224
Vascular Endothelial Growth Factor Regulator6229Downloadable Document
Antiprotozoal Agents6132
Antiemetics605
Interferon-gamma (IFN-gamma) inducer6018
Fertility Agents: Male6014
Proteasome Inhibitors5940Downloadable Document
Estrogen Receptor Modulators5834Downloadable Document
Multidrug Resistance Gene Modulators5850
Interferon Gamma Reducer5824
Thermogenic579
Heme oxygenase-1 inducer5739
Serotonergic5612
Diuretics5514Downloadable Document
Cholagogues and Choleretics5412Downloadable Document
Antitussive Agents5414
STAT3 Inhibitor5331
Osteogenic5212
Interleukin-2 upregulation5113
Lipoxygenase Inhibitors5027Downloadable Document
Anti-Retroviral Agents4918
Lipolytic4918Downloadable Document
Quorum Sensing Inhibition4949
Interleukin-12 upregulation4813
Reverse Transcriptase Inhibitors4729Downloadable Document
Enzyme Inhibitors: Pancreatic Lipase4619
Histamine Antagonists4517Downloadable Document
Histamine Antagonists4517Downloadable Document
Aromatase Inhibitors4533Downloadable Document
Anabolic Agents4512Downloadable Document
GABA Modulators4417
Tumor Necrosis Factor (TNF) Alpha Enhancer4413
Heat Shock Protein Down-Regulation4222
Laxative426
Appetite Depressants429
Interferon Inducers4110
Chelating Agents4121
Iron Chelating Agents4015
Bax/Bcl2 ratio: Increase4032
Drug synergy4011Downloadable Document
Appetite Stimulants398
SIRT1 Activator3923
Leukotriene Antagonists389
Proton Pump Inhibitor3814Downloadable Document
Insulin Down-Regulation387
Neuromodulatory376
Ghrelin Down-Regulation366
5-alpha reductase inhibitor3515Downloadable Document
Glucagon Like Peptide 1 (GLP-1) Down-Regulation356
Antimycobacterial3519Downloadable Document
Bcl-xL down-regulation3526
5-Lipoxygenase Inhibitor3521
Analgesics: Non-Narcotic3510
Cholecystokinin (CCK) Up-regulation345
Uterotonic3411Downloadable Document
Spermatogenic3412
Transforming growth factor beta (TGF-β) upregulation3214
Dopaminergic3210Downloadable Document
Interleukin-6 upregulation3211
Photosensitizing Agents3215
Caspase-8 activation3222
Cholinesterase Inhibitors3223
Aldose reductase inhibitor329
HIV Protease Inhibitors3119Downloadable Document
Antiurolithiatic319
Carcinogens312
Interleukin-8 upregulation303
Protein Kinase Inhibitors2919Downloadable Document
Bax/Bcl2 Ratio: Decrease2918
Enzyme Activators2918
Fibrinolytic Agents287
Prostaglandin Antagonists2713Downloadable Document
Adiponectin Down-Regulation278
Glucose Uptake Optimization269
Androgen Antagonists255
Detoxifier: Radionuclide Removal255
Interleukin-22 Downregulation2410
Leptin Down-Regulation238
Monocyte chemotattractant protein-1 (MCP-1) Inhibitor234
Natriuretic Agents234
Viral Hemagglutinin Inhibitor2216Downloadable Document
Gluconeogenesis Inhibitor2115Downloadable Document
Fibroblast growth factor 21 upregulation2111
Chymotrypsin Inhibitor212
Hypnotics and Sedatives206
Adenosine deaminase inhibitor207
Neurominidase Inhibitor2019Downloadable Document
Cholecystokinin Releaser202
Hematopoietic209
Topoisomerase II Inhibitor1917
Anticoagulants1815
Tyrosinase inhibitors1817
Peptide YY (PYY) Up-Regulation164
P38 Mitogen-Activated Protein Kinase Modulator1611
Glucose transporter-1 (GLUT1) expression down-regulation168
Antitubercular Agents155
Oncogene Suppressor1511Downloadable Document
Survivin Down-Regulation1513
Hepatocyte growth factor (HGF) inhibitor154
Protease Inhibitors156
Antipsychotic Agents152
Antioxidant Effects154
Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor144
Paraptosis1414
Cell Differentiation Inducer1411
Neocardiogenic1411
Glutathione S-transferase Inhibitor144
Teratogens143
Leukotriene B4 downregulation134
Anti-collagenase132
Topoisomerase I inhibitor1311
Matrix Metalloproteinase-12 (MMP-12) Inhibitor137
Insulin Receptor Modulator122
Endocannabinoid down-regulation122
Carminative122
VEGFR3 inhibition123
Dopamine Agents122
Metallothionein Up-regulation122
Mucolytic122
Anti-edemic122
Immunomodulatory: Innate Immunity Up-Regulation122
Immunomodulatory: T-Cell down-regulation122
Vasopressin Inhibitor122
Adrenergic alpha-Antagonists112
Mitogen-activated protein kinase inhibitors112
Mitogen-activated protein kinase kinase 4 (MEK4)112
Insulinotrophic117
Interleukin-1 receptor antagonist112
NOX2 inhibitor101
Matrix Metalloproteinases Inhibitors106
cAMP up-regulation101
Immune Enhancing Properties101
Fatty Acid Oxidation101
Glucose transporter-2 (GLUT2) expression up-regulation101
Oxytocin inducer101
Respiratory System Agents101
STAT3 Activation108
Insulin Antagonists101
Interleukin 1 receptor antagonist (IL-1Ra) up-regulation101
Peptide YY (PYY) Down-regulation101
Immunomodulatory: CD23+ Mature Macrophage Down-Regulation101
Immunostimulatory: IgA Production Up-Regulation101
Isoprostane Down-Regulation101
Phosphorylase Kinase Inhibitors101
Hormones101
Central Nervous System Depressants101
Glutathione peroxidase 1 (GPx1) inhibitors101
PER2 Protein Expression Up-regulation101
Drug sparing101
Immunomodulatory: Immunoglobulin G up-regulation101
Gastric Inhibitory Polypeptide Up-Regulation101
Diacylglyceride acyltransferase 1 (DGAT1) Inhibition101
Interleukin-13 Up-Regulation101
Antilipemic Agents101
Interleukin-23 Downregulation101
Neurotransmitter Uptake Inhibitors101
Interleukin-3 upregulation101
Intracellular adhesion molecule down-regulation101
Alkylating Agents101
Cannabinoid Receptor Antagonist/Inverse Agonist97
Insulin-mimetic96
Caspase-7 Activation97
Glutathione Peroxidase 1 (GPx1) Up-Regulation95
Redox Modulator95
Selective estrogen enzyme modulator (SEEM)97
Analgesics: Opioid96
Enzyme Inhibitors: Pancreatic Amylase86
Vascular Endothelial Growth Factor D Inhibitor84
NADPH Oxidase Inhibitors84
Benzodiazepine receptor agonist86
Selective Estrogen Receptor Modulators85
Insecticidal84
15-Lipoxygenase (15-LOX) Inhibitor86
Prostaglandin E Synthase-1 (PGES-1) Down-Regulation72
Adenosine Monophosphate (AMP)-activated Protein Kinase (AMPK72
Antigiardial agents74
Excitatory Amino Acid Agonists74
HER-2 oncoprotein down-regulation72
Vascular smooth muscle cell (VSMC) inhibitor75
Monoaminergic63
Interleukin-18 upregulation64
Trypanocidal Agents65
Caspase-3 Inhibition64
Trypsin Inhibitors64
AMP-activated protein kinase modulation64
Interleukin-21 downregulation63
5-Lipoxygenase Inhibitor65
PI3K-AKT inhibitor64
Anti-Estrogenic64
Spermicidal Activity51
Protein tyrosine phosphatase 1B (PTP1B) modulator53
Insulin-Like Growth Factor Enhancer/Upregulation53
HMG-CoA reductase inhibitor54
Thromboxane (TXB) Inhibitors54
Anti-Arrhythmia Agents53
HIV Fusion Inhibitors54
Antacids51
Extracellular Signal-Regulated Kinases Modulator54
Monoamine Oxidase Inhibitors42
Intracellular adhesion molecule-1 (ICAM-1)43
Erythropoietic43
Adrenergic alpha-Agonists43
Tumor Suppressor Protein p73 Upregulation43
Metal Chelation: Copper43
Anticholinergic42
Thrombolytic42
Ghrelin Up-regulation42
Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Upregulation42
Contraceptive Agents: Male42
Matrix Metalloproteinase-7 (MMP-7) Inhibitor41
Mitochondrial Superoxide Dismutase Upregulation43
Schistosomicides42
SGLT1 inducer42
Angiotensin II Type 1 Receptor Blockers42
Anti-Inflammatory Agents: Non-Steroidal42
Phase I Detoxification Enzyme Inducer42
Immunomodulatory: Regulatory T Cell Up-Regulation42
Antithrombotic42
Vascular Endothelial Growth Factor A Enhancer42
Platelet aggregation inhibitor: collagen-induced aggregation32
HIV-1 Integrase Inhibitor33
Estradiol 3-glucuronide enhancer33
Forkhead Transcription Factor Family O (FOXO) Modulator32
Antimitotic Agents33
NF-kappa-B-inducing kinase (NIK) modulator32
Survival protein down-regulation32
Adrenergic beta-Agonists32
Anti-Infective Agents: Urinary32
Estrogen Receptor Agonist33
Chemokine (C-C motif) Ligand 2 (CCL2) Down-Regulation32
Cholinergic Agents32
Interleukin-1 alpha upregulation32
Histamine down-regulation32
Quinone Reductase-Inducer32
Cholinergic Antagonists32
Matrix metalloproteinase-8 (MMP-8) inhibitor32
Steroidogenesis32
Interleukin-15 downregulation32
Atrial Natriuretic Factor Modulation32
Expectorants32
TRAIL sensitizer32
Glucose transporter-2 (GLUT2) expression down-regulation32
Cyclin-Dependent Kinase Inhibitor33
Neutrophil Activation: Down-Regulation21
Lymphagogue21
Enzyme Inhibitors: Maltase Inhibition21
Insecticides21
Food Preservatives22
Cicatrizing21
Cyclin-Dependent Kinase Inhibitor: P1622
Death receptor up-regulation21
Histamine Agents21
Myorelaxant21
Anesthetics21
RANTES (CCL5) Inhibitor22
Coccidiostats21
Vascular Endothelial Growth Factor C Inhibitor21
Histamine Agonists21
Myosin heavy chain alpha (MHCalpha) reducer21
P-glycoprotein Inhibitors22
Endothelin-1 Inhibitor21
Reactive Oxygen Species (ROS) attenuation22
Bronchoconstrictor Agents21
Serotonin Agonists21
Fertility Agents21
Central Nervous System Agents21
Adenosine Monophosphate (AMP)-Activated Protein Kinase (AMPK) Down-Regulation21
Antiparkinson Agents21
Opioid Endogenous Up-regulation21
Leukotriene C4 Downregulation22
Arginine Vasopressin (AVP) up-regulation.21
Receptor-Related Orphan Receptor (ROR)-Alpha1 Inhibitor21
Immunomodulatory: CD8+ Up-regulation21
Serum ceruloplasmin oxidase reducer21
Thromboxane B2 Inhibitor22
GSH-Px Up-Regulation21
Akt-dependent HO-1 expression up-regulation21
Uncoupling Agents21
JAM3 gene down-regulation21
Angiogenesis Modulating Agents21
Human androgen receptor (AR) antagonist22
Redox Balancer21
C-Jun N-Terminal Kinases (JNK) Modulator22
ER alpha receptor up-regulation21
Incretin Modulator21
Stearoyl coenzyme A desaturase-1 modulator21
AKT-mammalian target of rapamycin (mTOR) pathway inhibitor22
Peroxisome Proliferators21
Progestagenic21
Environmental Pollutants21
ER beta receptor up-regulation21
Sigma-1 Receptor Agonist22
Inhibitor of Nuclear Factor Kappa-B Kinase (IKK)22
Antinitrosation21
Adjuvants: Immunologic21
Muscarinic Agonists21
Nootropic Agents21
Ovogenic21
Lipotropic Agents21
Progesterone receptor (PR) up-regulation21
Hydroperoxidase Inhibitor21
Calcium Desensitizer21
Stomachic21
1-Glutamine Uptake Inhibitor22
Abortifacient Agents21
Adrenergic Agents21
Tumor Necrosis Factor (TNF) Alpha Upregulation21
Muscarinic Antagonists22
Noradrenergic21
Phase I Detoxification Enzyme Inhibitor21
Remyelination21
Follicle-stimulating hormone receptor (FSHR) up-regulation21
Antidiuretic Agents21
Gene Protective21
Glycine Agents21
Adrenergic Agonists22
High-mobility group box-1 (HMGB1) inhibitor21
Muscle Relaxants: Central11
Oxytocics11
Matrix metalloproteinase-14 (MMP-14) inhibitor11
β-secretase Inhibitor11
RANK Downregulation11
Serine Proteinase Inhibitors11
17beta-hydroxysteroid dehydrogenase inhibitor11
Neuroimmunomodulation11
IRAK-MAPK Modulator11
Phosphodiesterase Inhibitors11
Matrix metalloproteinase-17 (MMP-17) inhibitor11
Endocannabinoid Modulator11
Breast cancer resistance protein (BCRP) down-regulation11
Cancerous inhibitor of protein phosphatase 2A inhibitor11
Caspase-14 Upregulation11
Fatty Acid Synthesis Inhibitors11
Superoxide Scavenger11
Antifibrinolytic Agents11
Glucose transporter-5 (GLUT5) expression down-regulation11
Transient Receptor Potential Melastatin 2 Inhibition11
Glyoxalase 1 inhibitor11
Tyrosinase Inhibition11
Cyclin-dependent kinase inhibitor: P16INK411
Phospholipase D Inhibitors11
Prostaglandin H Synthase-1 (PGHS-1) Inhibits11
Dopamine Agonists11
Estrogen Antagonists11
5-HTergic11
Contraceptive Agents11
Hemolytic Agents11
Alpha-hemolysin inhibitor11
Arginase 1 (Arg1) up-regulation11
mTOR/S6K pathway Activator11
P16 Activation11
Maspin (Protease Inhibitor) Up-Regulation11
PPAR-Gamma Up-Regulation11
Prostaglandin H Synthase-2 (PGHS-2) Up-Regulation11
Vitamin D Receptor (VDR) Modulator11
Psychedelic11
Enkephalinase inhibitor11
Hypomethylating11
Anti-cancer11
S-phase kinase associated protein 2 inhibition11
Carbonyl Reductase 1Inhibitor11
STAT3-NFκB Signaling: downregulation11
5-Hydroxyeicosatetraenoic acid (5-HETE) Inhibitor11
Leukotriene D4 antagonist11
Mast Cell Activation Inhibitor11
PRL-3 Down-Regulation11
Enoyl-acyl Carrier Protein (ACP) Reductase Inhibitors11
Cryoprotective Agents11
p300/NF-κB down-regulation11
Lactate Dehydrogenase A Inhibitor11
Astringents11
Histamine up-regulation11
Human Polymorphonuclear Leukocyte Degranulation Inhibitor11
Antidepressive Agents: Second-Generation11
Akt-SREBP-1 activater11
Dipeptidyl-Peptidase IV Inhibitors11
Neovasculogenesis11
Interleukin-1 beta upregulation11
Matrix Metalloproteinase-8 Inhibitor11
E-cadherin down-regulation11
Beta-Defensin-2 Up-Regulation11
Hypoxia-inducible factor-1 (HIF-1) inhibitor11
Insect Repellents11
Antibiotics: Antifungal11
Antilipolytic11
Chondroprotective11
Cyclin-Dependent Kinase 4 Down-Regulation11
Hematologic Agents11
Herbicides11
Disinfectants11
Molecular Probes11
Oxidants11
Palmitoylation Inhibitors11
PI3K/Akt/signaling suppression11
Zinc-dependent metalloproteinase inhibitor11
Emmenagogue11
Beta-Endorphin Enhancer11
Hydroxyheptadecatrienoate (HHT) Inhibitor11
Calcium/calmodulin dependent protein kinase II inhibitor11
IGF-1R expression down-regulation11
Eryptotic11
Sulfonation11
Cytotoxins11

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