Natural Health Research Discovery

Each Topic is an Index of Curated Biomedical Research Abstracts

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Pharmacological Actions

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Pharmacological Actions (501)

ALLA B C D E F G H I J L M N O P Q R S T U V W X Z Β
Pharmacological Action NameCumulative Knowledgesort iconAbstractsPDF
Antioxidants215288856Downloadable Document
Anti-Inflammatory Agents208598334Downloadable Document
Neuroprotective Agents104044396Downloadable Document
Apoptotic69865304Downloadable Document
Antiproliferative68015032Downloadable Document
Tumor Necrosis Factor (TNF) Alpha Inhibitor67362815Downloadable Document
Cardioprotective53771675Downloadable Document
Chemopreventive53741717Downloadable Document
Hypoglycemic Agents53661338Downloadable Document
Hypolipidemic53581221Downloadable Document
Hepatoprotective50982264Downloadable Document
Interleukin-6 Downregulation50291994Downloadable Document
Antidepressive Agents4882874Downloadable Document
Antihypertensive Agents4527683Downloadable Document
Immunomodulatory40481475Downloadable Document
NF-kappaB Inhibitor35362098Downloadable Document
Analgesics3498646Downloadable Document
Gastrointestinal Agents3145843
Anticholesteremic Agents3078530Downloadable Document
Interleukin-1 beta downregulation30411567Downloadable Document
Anti-Anxiety Agents2913487
Anti-Apoptotic29051672Downloadable Document
Anti-Bacterial Agents28941251Downloadable Document
Renoprotective24041075Downloadable Document
Chemotherapeutic23281086
Chemoprotective Agents2322906
Malondialdehyde Down-regulation2065678Downloadable Document
Anti-metastatic19721481Downloadable Document
Antiviral Agents19571034Downloadable Document
Anticarcinogenic Agents1890889Downloadable Document
Antineoplastic Agents18471170Downloadable Document
Cell cycle arrest16781348Downloadable Document
Radioprotective1668521Downloadable Document
Cyclooxygenase 2 Inhibitors1589926Downloadable Document
Nrf2 activation1584916
Superoxide Dismutase Up-regulation1403551Downloadable Document
Antimicrobial1209582Downloadable Document
Insulin Sensitizers1185244Downloadable Document
Chemosensitizer1124854Downloadable Document
MicroRNA modulator1023618
Osteoprotective971351
Gastroprotective955388Downloadable Document
Anti-Fibrotic924463Downloadable Document
Matrix metalloproteinase-9 (MMP-9) inhibitor786505Downloadable Document
Prophylactic Agents780182
Matrix metalloproteinase-2 (MMP-2) inhibitor727442Downloadable Document
Enzyme Inhibitors692347Downloadable Document
Anticonvulsants678189Downloadable Document
Cytoprotective659326
Antinoceceptive647197Downloadable Document
Detoxifier644202Downloadable Document
Immunostimulatory633192Downloadable Document
Vasodilator Agents626169Downloadable Document
Heme oxygenase-1 up-regulation624373
Tumor Suppressor Protein p53 Upregulation585431Downloadable Document
Interleukin-8 downregulation581231Downloadable Document
Bcl-2 protein down-regulation553407Downloadable Document
Anti-Ulcer Agents523184Downloadable Document
Autophagy Up-regulation518349Downloadable Document
Nitric Oxide Inhibitor498258Downloadable Document
Antifungal Agents494306Downloadable Document
Angiogenesis Inhibitors488296
Genoprotective477177Downloadable Document
Anxiolytic47566Downloadable Document
Hypotensive46763Downloadable Document
Brain-derived neurotrophic factor modulator458166
Photoprotective446198
Anti-Allergic Agents442150Downloadable Document
Antidiarrheals43987
Vascular Endothelial Growth Factor Inhibitors435247
Regenerative408172
Pancreato Protective Agents358194
Interleukin-4 downregulation355128Downloadable Document
Anti-atherogenic348120
Anti-Angiogenic347234Downloadable Document
Interleukin-10 downregulation335128Downloadable Document
Glutathione Upregulation29996Downloadable Document
Radiosensitizer291182Downloadable Document
Anti-Asthmatic Agents28671
Alpha-glucosidase inhibitor274201Downloadable Document
Dermatologic Agents27232Downloadable Document
Catalase Up-Regulation264112
Nitric Oxide Enhancer26176Downloadable Document
Telomere Protective23129
Adiponectin upregulation21739
Neurogenesis215109
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor214142
Wnt/β-catenin signaling pathway modulation208149
Antiparasitic Agents208121Downloadable Document
Vasoprotective20752
Uricosuric Agents20544
Transforming growth factor beta (TGF-β) inhibitor203106
Postaglandin PGE2 downregulation202110
Cardiovascular Agents20132Downloadable Document
Platelet Aggregation Inhibitors20045Downloadable Document
Anti-Glycation Agents197100
Interleukin-17 downregulation19385
Prostaglandin PGE2 downregulation19388Downloadable Document
Neuritogenic18589Downloadable Document
Vascular Endothelial Growth Factor A Inhibitor17997Downloadable Document
Immunomodulatory: Th17 downregulation17781
Autophagy Inhibitors175115
Alpha-amylase inhibitor175110
Acetylcholinesterase Inhibitor17095Downloadable Document
Matrix metalloproteinase-3 (MMP-3) inhibitor16968
Anti-Adipogenic16485Downloadable Document
Antimutagenic Agents16499Downloadable Document
P21 Activation160119
Anti-Tumor15476Downloadable Document
Matrix Metalloproteinase-13 (MMP-13) Inhibitor14566
Antispasmodic14037Downloadable Document
Interleukin-12 downregulation13953
Telomerase Upregulation13734Downloadable Document
Caspase-3 Activation13790Downloadable Document
Anti-Platelet13747Downloadable Document
Anti-HIV Agents13384Downloadable Document
Interleukin-18 down-regulation13261
Glucagon Like peptide 1 (GLP-1) Up-regulation12935Downloadable Document
Heat Shock Protein Inducer12648Downloadable Document
Interleukin-2 Downregulation12351
Vascular Cell Adhesion Molecule-1 Inhibitor12334Downloadable Document
Insulin-releasing12249Downloadable Document
Interleukin-5 downregulation12049
Leishmanicidal11879Downloadable Document
Interleukin-4 upregulation11342
Cardiotonic Agents10610
Cyclin D1 Down-Regulation10679
Interleukin-10 upregulation10524
Interleukin-1 alpha downregulation10242Downloadable Document
Angiotensin-Converting Enzyme Inhibitors9954Downloadable Document
Matrix metalloproteinase-1 (MMP-1) inhibitor9959
Histone deacetylase inhibitor9869Downloadable Document
Calcium Channel Blockers9829Downloadable Document
Phase II Detoxification Enzyme Inducer9552Downloadable Document
Telomerase Inhibitor9562Downloadable Document
DNA Repair Up-regulation9327
Fertility Agents: Female9018
interleukin-13 down-regulation9047
Angiogenesis Inducing Agents8845
Epidermal growth factor receptor (EGFR) inhibitor8760Downloadable Document
Insulin-Like Growth Factor Inhibition/Downregulation8618Downloadable Document
Neuroplasticity enhancement8323
Immunosuppressive Agents8043Downloadable Document
Anti-Cachexic Agents7926
Bronchodilator Agents7815Downloadable Document
Anti-thrombotic7632Downloadable Document
Cytotoxic7660
Cyclooxygenase Inhibitors7442Downloadable Document
Galactogogue738
Neurorestorative7121Downloadable Document
Caspase-9 Activation7046
Xanthine oxidase inhibitor6934Downloadable Document
NF-E2-Related Factor-2 (Nrf2) Modulator6939
Anti-Proliferative6755Downloadable Document
Aphrodisiac6722Downloadable Document
Cyclooxygenase 1 Inhibitor6548Downloadable Document
Appetite Suppresant6414
Anti-pyretic6224
Vascular Endothelial Growth Factor Regulator6229Downloadable Document
Malonaldehyde (MDA) Down-Regulation6215
Antiprotozoal Agents6132
Fertility Agents: Male6014
Interferon-gamma (IFN-gamma) inducer6018
Proteasome Inhibitors5940Downloadable Document
Interferon Gamma Reducer5824
Estrogen Receptor Modulators5834Downloadable Document
Thermogenic579
Heme oxygenase-1 inducer5739
Cholagogues and Choleretics5412Downloadable Document
STAT3 Inhibitor5331
Osteogenic5212
Lipoxygenase Inhibitors5027Downloadable Document
Anti-Retroviral Agents4918
Quorum Sensing Inhibition4949
Lipolytic4918Downloadable Document
Interleukin-12 upregulation4813
Reverse Transcriptase Inhibitors4729Downloadable Document
Enzyme Inhibitors: Pancreatic Lipase4619
Histamine Antagonists4517Downloadable Document
Histamine Antagonists4517Downloadable Document
Tumor Necrosis Factor (TNF) Alpha Enhancer4413
Appetite Depressants429
Laxative426
Chelating Agents4121
Interferon Inducers4110
Bax/Bcl2 ratio: Increase4032
Iron Chelating Agents4015
SIRT1 Activator3923
Insulin Down-Regulation387
Ghrelin Down-Regulation366
Antimycobacterial3519Downloadable Document
5-Lipoxygenase Inhibitor3521
Glucagon Like Peptide 1 (GLP-1) Down-Regulation356
Cholecystokinin (CCK) Up-regulation345
Uterotonic3411Downloadable Document
Spermatogenic3412
Transforming growth factor beta (TGF-β) upregulation3214
Interleukin-6 upregulation3211
Caspase-8 activation3222
HIV Protease Inhibitors3119Downloadable Document
Antiurolithiatic319
Carcinogens312
Interleukin-8 upregulation303
Bax/Bcl2 Ratio: Decrease2918
Enzyme Activators2918
Protein Kinase Inhibitors2919Downloadable Document
Adiponectin Down-Regulation278
Glucose Uptake Optimization269
Androgen Antagonists255
Detoxifier: Radionuclide Removal255
Interleukin-22 Downregulation2410
Leptin Down-Regulation238
Natriuretic Agents234
Viral Hemagglutinin Inhibitor2216Downloadable Document
Fibroblast growth factor 21 upregulation2111
Chymotrypsin Inhibitor212
Neurominidase Inhibitor2019Downloadable Document
Hypnotics and Sedatives206
Adenosine deaminase inhibitor207
Cholecystokinin Releaser202
Topoisomerase II Inhibitor1917
Anticoagulants1815
P38 Mitogen-Activated Protein Kinase Modulator1611
Peptide YY (PYY) Up-Regulation164
Antipsychotic Agents152
Hepatocyte growth factor (HGF) inhibitor154
Antioxidant Effects154
Antitubercular Agents155
Protease Inhibitors156
Survivin Down-Regulation1513
Cell Differentiation Inducer1411
Teratogens143
Paraptosis1414
Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor144
Leukotriene B4 downregulation134
Matrix Metalloproteinase-12 (MMP-12) Inhibitor137
Anti-collagenase132
Topoisomerase I inhibitor1311
Dopamine Agents122
Carminative122
Insulin Receptor Modulator122
Vasopressin Inhibitor122
Anti-edemic122
VEGFR3 inhibition123
Mucolytic122
Immunomodulatory: T-Cell down-regulation122
Mitogen-activated protein kinase inhibitors112
Insulinotrophic117
Interleukin-1 receptor antagonist112
Mitogen-activated protein kinase kinase 4 (MEK4)112
PER2 Protein Expression Up-regulation101
Gastric Inhibitory Polypeptide Up-Regulation101
Immune Enhancing Properties101
Insulin Antagonists101
Antilipemic Agents101
Immunostimulatory: IgA Production Up-Regulation101
Isoprostane Down-Regulation101
Immunomodulatory: CD23+ Mature Macrophage Down-Regulation101
Drug sparing101
Respiratory System Agents101
Hormones101
Glutathione peroxidase 1 (GPx1) inhibitors101
Neurotransmitter Uptake Inhibitors101
Diacylglyceride acyltransferase 1 (DGAT1) Inhibition101
Immunomodulatory: Immunoglobulin G up-regulation101
Interleukin 1 receptor antagonist (IL-1Ra) up-regulation101
Interleukin-23 Downregulation101
Peptide YY (PYY) Down-regulation101
STAT3 Activation108
Alkylating Agents101
NOX2 inhibitor101
Oxytocin inducer101
Intracellular adhesion molecule down-regulation101
Fatty Acid Oxidation101
Interleukin-3 upregulation101
Phosphorylase Kinase Inhibitors101
Interleukin-13 Up-Regulation101
Redox Modulator95
Insulin-mimetic96
Insecticidal84
Antigiardial agents74
Prostaglandin E Synthase-1 (PGES-1) Down-Regulation72
Vascular smooth muscle cell (VSMC) inhibitor75
Adenosine Monophosphate (AMP)-activated Protein Kinase (AMPK72
Excitatory Amino Acid Agonists74
AMP-activated protein kinase modulation64
Trypsin Inhibitors64
Monoaminergic63
5-Lipoxygenase Inhibitor65
HIV Fusion Inhibitors54
Antacids51
Spermicidal Activity51
Insulin-Like Growth Factor Enhancer/Upregulation53
Extracellular Signal-Regulated Kinases Modulator54
Anticholinergic42
Mitochondrial Superoxide Dismutase Upregulation43
Adrenergic alpha-Agonists43
Angiotensin II Type 1 Receptor Blockers42
Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Upregulation42
Erythropoietic43
Phase I Detoxification Enzyme Inducer42
Antithrombotic42
SGLT1 inducer42
Contraceptive Agents: Male42
Matrix Metalloproteinase-7 (MMP-7) Inhibitor41
Anti-Inflammatory Agents: Non-Steroidal42
Monoamine Oxidase Inhibitors42
Thrombolytic42
Vascular Endothelial Growth Factor A Enhancer42
Immunomodulatory: Regulatory T Cell Up-Regulation42
Ghrelin Up-regulation42
Schistosomicides42
Intracellular adhesion molecule-1 (ICAM-1)43
Steroidogenesis32
NF-kappa-B-inducing kinase (NIK) modulator32
TRAIL sensitizer32
Interleukin-15 downregulation32
Quinone Reductase-Inducer32
Glucose transporter-2 (GLUT2) expression down-regulation32
Adrenergic beta-Agonists32
Estradiol 3-glucuronide enhancer33
Chemokine (C-C motif) Ligand 2 (CCL2) Down-Regulation32
Cholinergic Agents32
Matrix metalloproteinase-8 (MMP-8) inhibitor32
Cholinergic Antagonists32
Survival protein down-regulation32
Atrial Natriuretic Factor Modulation32
Forkhead Transcription Factor Family O (FOXO) Modulator32
Cyclin-Dependent Kinase Inhibitor33
Histamine down-regulation32
Vascular Endothelial Growth Factor C Inhibitor21
Cicatrizing21
Cyclin-Dependent Kinase Inhibitor: P1622
Death receptor up-regulation21
Antinitrosation21
Abortifacient Agents21
Muscarinic Agonists21
Adrenergic Agents21
Angiogenesis Modulating Agents21
Opioid Endogenous Up-regulation21
Insecticides21
Fertility Agents21
Peroxisome Proliferators21
Coccidiostats21
Serotonin Agonists21
Stomachic21
C-Jun N-Terminal Kinases (JNK) Modulator22
Environmental Pollutants21
Central Nervous System Agents21
1-Glutamine Uptake Inhibitor22
Remyelination21
Myorelaxant21
Uncoupling Agents21
GSH-Px Up-Regulation21
Leukotriene C4 Downregulation22
Phase I Detoxification Enzyme Inhibitor21
Myosin heavy chain alpha (MHCalpha) reducer21
Akt-dependent HO-1 expression up-regulation21
Calcium Desensitizer21
Ovogenic21
Histamine Agents21
Gene Protective21
Adenosine Monophosphate (AMP)-Activated Protein Kinase (AMPK) Down-Regulation21
Arginine Vasopressin (AVP) up-regulation.21
AKT-mammalian target of rapamycin (mTOR) pathway inhibitor22
Nootropic Agents21
JAM3 gene down-regulation21
Histamine Agonists21
Immunomodulatory: CD8+ Up-regulation21
Incretin Modulator21
Enzyme Inhibitors: Maltase Inhibition21
Follicle-stimulating hormone receptor (FSHR) up-regulation21
Antidiuretic Agents21
RANTES (CCL5) Inhibitor22
Antiparkinson Agents21
Anesthetics21
Thromboxane B2 Inhibitor22
Noradrenergic21
Human androgen receptor (AR) antagonist22
Inhibitor of Nuclear Factor Kappa-B Kinase (IKK)22
Food Preservatives22
Progestagenic21
Receptor-Related Orphan Receptor (ROR)-Alpha1 Inhibitor21
Neutrophil Activation: Down-Regulation21
Glycine Agents21
Lymphagogue21
Progesterone receptor (PR) up-regulation21
Redox Balancer21
Adjuvants: Immunologic21
Bronchoconstrictor Agents21
Tumor Necrosis Factor (TNF) Alpha Upregulation21
P-glycoprotein Inhibitors22
Hydroperoxidase Inhibitor21
Endothelin-1 Inhibitor21
ER beta receptor up-regulation21
Psychedelic11
Matrix metalloproteinase-17 (MMP-17) inhibitor11
Serine Proteinase Inhibitors11
Neuroimmunomodulation11
P16 Activation11
Glyoxalase 1 inhibitor11
Ionophores11
Histamine up-regulation11
Hydroxyheptadecatrienoate (HHT) Inhibitor11
IGF-1R expression down-regulation11
Enkephalinase inhibitor11
Eryptotic11
Interleukin-1 beta upregulation11
Vitamin D Receptor (VDR) Modulator11
PI3K/Akt/signaling suppression11
Cyclin-dependent kinase inhibitor: P16INK411
Muscle Relaxants: Central11
Alpha-hemolysin inhibitor11
Tyrosinase Inhibition11
IRAK-MAPK Modulator11
p300/NF-κB down-regulation11
PKM2 downregulation11
Contraceptive Agents11
Prostaglandin H Synthase-1 (PGHS-1) Inhibits11
Maspin (Protease Inhibitor) Up-Regulation11
Sulfonation11
Herbicides11
Dopamine Agonists11
Glucose transporter-5 (GLUT5) expression down-regulation11
Prostaglandin H Synthase-2 (PGHS-2) Up-Regulation11
Mast Cell Activation Inhibitor11
Antilipolytic11
17beta-hydroxysteroid dehydrogenase inhibitor11
Molecular Probes11
Arginase 1 (Arg1) up-regulation11
Transient Receptor Potential Melastatin 2 Inhibition11
Leukotriene D4 antagonist11
Zinc-dependent metalloproteinase inhibitor11
Cryoprotective Agents11
5-HTergic11
Superoxide Scavenger11
Beta-Defensin-2 Up-Regulation11
Calcium/calmodulin dependent protein kinase II inhibitor11
Oxidants11
Hematologic Agents11
Hypomethylating11
E-cadherin down-regulation11
Anti-cancer11
Phosphodiesterase Inhibitors11
Antibiotics: Antifungal11
β-secretase Inhibitor11
PPAR-Gamma Up-Regulation11
Matrix Metalloproteinase-8 Inhibitor11
5-Hydroxyeicosatetraenoic acid (5-HETE) Inhibitor11
Neovasculogenesis11
Astringents11
Akt-SREBP-1 activater11
Cancerous inhibitor of protein phosphatase 2A inhibitor11
Oxytocics11
Lactate Dehydrogenase A Inhibitor11
Emmenagogue11
Phospholipase D Inhibitors11
Chondroprotective11
Cyclin-Dependent Kinase 4 Down-Regulation11
Antifibrinolytic Agents11
S-phase kinase associated protein 2 inhibition11
mTOR/S6K pathway Activator11
Breast cancer resistance protein (BCRP) down-regulation11
Carbonyl Reductase 1Inhibitor11
Human Polymorphonuclear Leukocyte Degranulation Inhibitor11
Dipeptidyl-Peptidase IV Inhibitors11
Endocannabinoid Modulator11
Insect Repellents11
Matrix metalloproteinase-14 (MMP-14) inhibitor11
Cytotoxins11
Hemolytic Agents11
Hypoxia-inducible factor-1 (HIF-1) inhibitor11
Disinfectants11
Fatty Acid Synthesis Inhibitors11

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