Anti-Inflammatory Agents | 39493 | 15764 |  |
Antioxidants | 34418 | 14437 |  |
Neuroprotective Agents | 19860 | 7879 |  |
Tumor Necrosis Factor (TNF) Alpha Inhibitor | 11649 | 4787 |  |
Antiproliferative | 9975 | 7471 |  |
Analgesics | 9622 | 1463 |  |
Apoptotic | 9570 | 7368 |  |
Cardioprotective | 9419 | 2949 |  |
Interleukin-6 Downregulation | 9321 | 3602 |  |
Hepatoprotective | 8939 | 3817 |  |
Hypolipidemic | 8915 | 2013 |  |
Hypoglycemic Agents | 8747 | 2035 |  |
Antidepressive Agents | 7888 | 1459 |  |
Gastrointestinal Agents | 7599 | 2251 |  |
Antihypertensive Agents | 6955 | 1013 |  |
Chemopreventive | 6568 | 2159 |  |
Immunomodulatory | 6505 | 2354 |  |
Interleukin-1 beta downregulation | 6042 | 2933 |  |
NF-kappaB Inhibitor | 5928 | 3450 |  |
Anti-Apoptotic | 5548 | 3145 |  |
Anti-Anxiety Agents | 4832 | 801 |  |
Renoprotective | 4538 | 1967 |  |
Chemotherapeutic | 4337 | 1618 |  |
Chemoprotective Agents | 4246 | 1618 | |
Anti-Bacterial Agents | 4225 | 1987 |  |
Anticholesteremic Agents | 4062 | 667 |  |
Nrf2 activation | 3150 | 1791 | |
Antiviral Agents | 3094 | 1701 |  |
Malondialdehyde Down-regulation | 3023 | 989 |  |
Anti-metastatic | 2865 | 2178 |  |
Radioprotective | 2387 | 711 |  |
Superoxide Dismutase Up-regulation | 2377 | 924 |  |
Cyclooxygenase 2 Inhibitors | 2258 | 1323 |  |
Antineoplastic Agents | 2235 | 1468 |  |
Anti-Fibrotic | 2204 | 1048 |  |
Anticarcinogenic Agents | 2152 | 1018 |  |
Cell cycle arrest | 2120 | 1715 |  |
Osteoprotective | 2037 | 685 | |
Insulin Sensitizers | 1940 | 415 |  |
Gastroprotective | 1673 | 696 |  |
Chemosensitizer | 1644 | 1266 |  |
Prophylactic Agents | 1617 | 324 | |
Antimicrobial | 1576 | 789 |  |
MicroRNA modulator | 1559 | 896 | |
Heme oxygenase-1 up-regulation | 1332 | 774 | |
Interleukin-10 upregulation | 1281 | 432 |  |
Anti-Ulcer Agents | 1250 | 341 |  |
Matrix metalloproteinase-9 (MMP-9) inhibitor | 1140 | 719 |  |
Interleukin-8 downregulation | 1106 | 401 |  |
Anticonvulsants | 1005 | 272 |  |
Antinoceceptive | 959 | 291 |  |
Matrix metalloproteinase-2 (MMP-2) inhibitor | 944 | 588 |  |
Vasodilator Agents | 890 | 232 |  |
Detoxifier | 853 | 253 |  |
Enzyme Inhibitors | 846 | 399 |  |
Autophagy Up-regulation | 836 | 558 |  |
Cytoprotective | 809 | 401 |  |
Photoprotective | 778 | 304 |  |
Immunostimulatory | 772 | 235 |  |
Tumor Suppressor Protein p53 Upregulation | 753 | 552 |  |
Brain-derived neurotrophic factor modulator | 744 | 279 |  |
Antifungal Agents | 729 | 421 |  |
Angiogenesis Inhibitors | 720 | 478 |  |
Bcl-2 protein down-regulation | 711 | 529 |  |
Nitric Oxide Inhibitor | 704 | 355 |  |
Vascular Endothelial Growth Factor Inhibitors | 611 | 335 |  |
Anti-Allergic Agents | 598 | 221 |  |
Transforming growth factor beta (TGF-β) inhibitor | 578 | 290 |  |
Interferon Gamma Reducer | 569 | 215 |  |
Pancreato Protective Agents | 552 | 298 | |
Antidiarrheals | 539 | 116 |  |
Genoprotective | 522 | 203 |  |
Anti-Asthmatic Agents | 510 | 148 |  |
Interleukin-17 downregulation | 502 | 192 |  |
Regenerative | 486 | 201 |  |
Anti-atherogenic | 482 | 162 |  |
Anxiolytic | 481 | 69 |  |
Hypotensive | 467 | 63 |  |
Interleukin-4 downregulation | 460 | 173 |  |
Fertility Agents: Male | 453 | 122 |  |
Vasoprotective | 451 | 108 |  |
Anti-Angiogenic | 416 | 280 |  |
Alpha-glucosidase inhibitor | 411 | 301 |  |
Catalase Up-Regulation | 403 | 165 |  |
Postaglandin PGE2 downregulation | 384 | 198 |  |
SIRT1 Activator | 381 | 189 |  |
Interleukin-18 down-regulation | 372 | 183 |  |
Radiosensitizer | 370 | 245 |  |
Interleukin-10 downregulation | 367 | 136 |  |
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor | 362 | 236 | |
Glutathione Upregulation | 359 | 110 |  |
Anti-Glycation Agents | 349 | 166 | |
Wnt/β-catenin signaling pathway modulation | 330 | 224 | |
Dermatologic Agents | 329 | 39 |  |
Uricosuric Agents | 328 | 83 |  |
Nitric Oxide Enhancer | 324 | 90 |  |
Neurogenesis | 323 | 172 |  |
STAT3 Inhibitor | 322 | 216 |  |
Antiparasitic Agents | 320 | 185 |  |
Autophagy Inhibitors | 302 | 188 | |
Wnt/β-catenin signaling pathway modulation | 300 | 224 | |
Angiogenesis Inducing Agents | 288 | 148 |  |
Telomere Protective | 281 | 39 |  |
Cytotoxic | 276 | 234 | |
Alpha-amylase inhibitor | 268 | 178 |  |
Acetylcholinesterase Inhibitor | 256 | 127 |  |
Laxative | 241 | 38 |  |
Matrix metalloproteinase-3 (MMP-3) inhibitor | 238 | 107 |  |
Vascular Endothelial Growth Factor A Inhibitor | 230 | 126 |  |
Matrix Metalloproteinase-13 (MMP-13) Inhibitor | 229 | 104 |  |
Adiponectin upregulation | 229 | 41 |  |
Immunomodulatory: Th17 downregulation | 225 | 99 |  |
Chondroprotective | 223 | 114 |  |
Neuritogenic | 222 | 107 |  |
Fertility Agents: Female | 221 | 49 |  |
Antimutagenic Agents | 218 | 138 |  |
Cardiovascular Agents | 215 | 35 |  |
Platelet Aggregation Inhibitors | 214 | 50 |  |
P21 Activation | 206 | 144 |  |
Interleukin-12 downregulation | 201 | 76 |  |
Prostaglandin PGE2 downregulation | 194 | 89 |  |
Anti-Adipogenic | 192 | 107 |  |
Interleukin-4 upregulation | 181 | 69 |  |
Secretagogue | 178 | 38 |  |
Interleukin-2 Downregulation | 177 | 73 |  |
Appetite Suppresant | 176 | 26 |  |
Osteogenic | 175 | 71 |  |
Insulin-releasing | 168 | 69 |  |
Anti-Tumor | 167 | 78 |  |
Leishmanicidal | 164 | 110 |  |
Interleukin-1 alpha downregulation | 162 | 67 |  |
Proliferative | 162 | 98 | |
Antioxidant Effects | 159 | 45 | |
Neuroplasticity enhancement | 158 | 54 | |
Heat Shock Protein Inducer | 156 | 57 |  |
Anti-HIV Agents | 155 | 96 |  |
Matrix metalloproteinase-1 (MMP-1) inhibitor | 155 | 92 |  |
Transforming growth factor beta (TGF-β) upregulation | 155 | 64 | |
Interleukin-5 downregulation | 154 | 65 |  |
interleukin-13 down-regulation | 150 | 75 |  |
Telomerase Upregulation | 149 | 37 |  |
Anti-Platelet | 144 | 50 |  |
Cyclin D1 Down-Regulation | 143 | 106 |  |
Antispasmodic | 141 | 38 |  |
Caspase-3 Activation | 137 | 90 |  |
Hypnotics and Sedatives | 137 | 54 |  |
Glucagon Like peptide 1 (GLP-1) Up-regulation | 131 | 36 |  |
Anti-Cachexic Agents | 129 | 50 | |
Angiotensin-Converting Enzyme Inhibitors | 129 | 63 |  |
Vascular Cell Adhesion Molecule-1 Inhibitor | 126 | 37 |  |
Antimalarials | 125 | 78 |  |
Anti-Androgen | 117 | 27 |  |
DNA Repair Up-regulation | 110 | 34 | |
Histone deacetylase inhibitor | 108 | 77 |  |
Interleukin-23 Downregulation | 107 | 42 | |
Cardiotonic Agents | 106 | 10 |  |
Immunosuppressive Agents | 103 | 52 |  |
Vascular Endothelial Growth Factor Regulator | 103 | 50 |  |
Phase II Detoxification Enzyme Inducer | 100 | 55 |  |
Calcium Channel Blockers | 98 | 29 |  |
Telomerase Inhibitor | 98 | 65 |  |
Wnt/β-catenin pathway down-regulation | 96 | 58 | |
Epidermal growth factor receptor (EGFR) inhibitor | 96 | 67 |  |
Anti-Infective Agents | 92 | 47 |  |
Antitussive Agents | 92 | 21 |  |
Xanthine oxidase inhibitor | 91 | 49 |  |
Bronchodilator Agents | 90 | 17 |  |
Quorum Sensing Inhibition | 90 | 85 | |
Hypoxia-inducible factor-1 (HIF-1) inhibitor | 89 | 33 |  |
Insulin-Like Growth Factor Inhibition/Downregulation | 88 | 19 |  |
Galactogogue | 87 | 11 |  |
Cyclooxygenase Inhibitors | 86 | 45 |  |
Cyclooxygenase 1 Inhibitor | 85 | 62 |  |
Appetite Depressants | 84 | 14 |  |
Anti-thrombotic | 79 | 34 |  |
Anti-pyretic | 76 | 33 |  |
Estrogen Receptor Modulators | 75 | 40 |  |
Tumor Necrosis Factor (TNF) Alpha Enhancer | 73 | 26 |  |
NF-E2-Related Factor-2 (Nrf2) Modulator | 72 | 41 |  |
Neurorestorative | 71 | 21 |  |
Caspase-9 Activation | 71 | 47 |  |
Aphrodisiac | 68 | 23 |  |
Anti-Proliferative | 68 | 56 |  |
Multidrug Resistance Gene Modulators | 67 | 57 | |
Malonaldehyde (MDA) Down-Regulation | 65 | 17 |  |
Heme oxygenase-1 inducer | 63 | 43 | |
Ergogenic | 63 | 8 | |
Interferon-gamma (IFN-gamma) inducer | 63 | 20 |  |
Antiemetics | 62 | 6 | |
Antiprotozoal Agents | 61 | 32 |  |
Iron Chelating Agents | 61 | 22 |  |
Proteasome Inhibitors | 60 | 41 |  |
Bax/Bcl2 ratio: Increase | 58 | 44 |  |
Thermogenic | 57 | 9 | |
Diuretics | 57 | 15 |  |
Serotonergic | 56 | 12 |  |
GABA Modulators | 55 | 23 |  |
Enzyme Inhibitors: Pancreatic Lipase | 54 | 25 |  |
Cholagogues and Choleretics | 54 | 12 |  |
Aromatase Inhibitors | 53 | 36 |  |
Photosensitizing Agents | 52 | 24 |  |
Lipolytic | 51 | 19 |  |
Anti-Retroviral Agents | 51 | 20 |  |
5-alpha reductase inhibitor | 51 | 18 |  |
Interleukin-2 upregulation | 51 | 13 |  |
Lipoxygenase Inhibitors | 50 | 27 |  |
Survivin Down-Regulation | 50 | 44 |  |
Heat Shock Protein Down-Regulation | 49 | 28 |  |
Interleukin-12 upregulation | 49 | 14 |  |
Reverse Transcriptase Inhibitors | 49 | 31 |  |
Chelating Agents | 48 | 25 |  |
5-Lipoxygenase Inhibitor | 48 | 31 |  |
Adiponectin Down-Regulation | 47 | 10 |  |
Insecticidal | 46 | 24 | |
5-Lipoxygenase Inhibitor | 46 | 31 | |
Anabolic Agents | 45 | 12 |  |
Histamine Antagonists | 45 | 17 |  |
Histamine Antagonists | 45 | 17 |  |
Fibroblast growth factor 21 upregulation | 44 | 18 | |
Acid Blockers | 42 | 17 |  |
Carcinogens | 42 | 6 | |
Interferon Inducers | 41 | 10 |  |
Bcl-xL down-regulation | 41 | 30 | |
Enzyme Activators | 40 | 25 |  |
Antiurolithiatic | 40 | 13 |  |
Drug synergy | 40 | 11 |  |
Appetite Stimulants | 39 | 8 | |
Cholinesterase Inhibitors | 38 | 28 |  |
Proton Pump Inhibitor | 38 | 14 |  |
Leukotriene Antagonists | 38 | 9 | |
Insulin Down-Regulation | 38 | 7 | |
Interleukin-22 Downregulation | 38 | 19 | |
Neuromodulatory | 37 | 7 | |
Glucagon Like Peptide 1 (GLP-1) Down-Regulation | 37 | 7 | |
Ghrelin Down-Regulation | 36 | 6 | |
Interleukin-8 upregulation | 35 | 5 | |
Analgesics: Non-Narcotic | 35 | 10 |  |
Antimycobacterial | 35 | 19 |  |
Uterotonic | 34 | 11 |  |
Spermatogenic | 34 | 12 |  |
Cholecystokinin (CCK) Up-regulation | 34 | 6 | |
HIV Protease Inhibitors | 33 | 21 |  |
Bax/Bcl2 Ratio: Decrease | 33 | 21 |  |
Interleukin-6 upregulation | 33 | 12 |  |
Protein Kinase Inhibitors | 32 | 21 |  |
Matrix Metalloproteinase-7 (MMP-7) Inhibitor | 32 | 21 |  |
Aldose reductase inhibitor | 32 | 9 | |
Dopaminergic | 32 | 10 |  |
Antipsychotic Agents | 32 | 14 |  |
Caspase-8 activation | 32 | 22 |  |
Matrix metalloproteinase-8 (MMP-8) inhibitor | 30 | 12 | |
Nootropic Agents | 30 | 18 |  |
STAT3 Activation | 29 | 20 | |
Fibrinolytic Agents | 28 | 7 | |
Androgen Antagonists | 27 | 6 | |
Prostaglandin Antagonists | 27 | 13 |  |
Vascular Endothelial Growth Factor C Inhibitor | 27 | 10 | |
Glucose Uptake Optimization | 26 | 9 | |
Interleukin-17 upregulation | 26 | 5 | |
Neurominidase Inhibitor | 25 | 24 |  |
Detoxifier: Radionuclide Removal | 25 | 5 | |
Fertility Agents | 24 | 9 | |
Remyelination | 24 | 13 |  |
Anti-cancer | 23 | 6 | |
Natriuretic Agents | 23 | 4 | |
Leptin Down-Regulation | 23 | 8 | |
Monocyte chemotattractant protein-1 (MCP-1) Inhibitor | 23 | 4 | |
Viral Hemagglutinin Inhibitor | 22 | 16 |  |
Topoisomerase II Inhibitor | 22 | 20 |  |
Anticoagulants | 22 | 18 |  |
Endothelin-1 Inhibitor | 22 | 3 | |
Matrix Metalloproteinase-12 (MMP-12) Inhibitor | 21 | 11 | |
Gluconeogenesis Inhibitor | 21 | 15 |  |
Adenosine deaminase inhibitor | 20 | 7 | |
Interleukin-18 upregulation | 20 | 11 | |
Fatty Acid Oxidation | 20 | 2 | |
Cholecystokinin Releaser | 20 | 2 | |
Hematopoietic | 20 | 9 | |
Insect Repellents | 19 | 12 |  |
Protease Inhibitors | 19 | 10 |  |
P38 Mitogen-Activated Protein Kinase Modulator | 18 | 12 |  |
Oncogene Suppressor | 18 | 14 |  |
Immune Enhancing Properties | 18 | 5 | |
Adenosine Monophosphate (AMP)-activated Protein Kinase (AMPK | 18 | 4 | |
Gene Protective | 18 | 6 | |
Tyrosinase inhibitors | 18 | 17 |  |
Topoisomerase I inhibitor | 17 | 15 |  |
Anticholinergic | 17 | 5 | |
Glucose transporter-1 (GLUT1) expression down-regulation | 16 | 8 | |
Monoamine Oxidase Inhibitors | 16 | 5 | |
Interleukin-21 downregulation | 16 | 4 | |
Peptide YY (PYY) Up-Regulation | 16 | 4 | |
Antithrombotic | 15 | 5 | |
Antitubercular Agents | 15 | 5 | |
Hepatocyte growth factor (HGF) inhibitor | 15 | 4 | |
Antilipemic Agents | 15 | 2 | |
Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor | 15 | 10 |  |
Interleukin-1 beta upregulation | 15 | 5 | |
Contraceptive Agents: Male | 14 | 3 | |
Cell Differentiation Inducer | 14 | 11 |  |
Neocardiogenic | 14 | 11 |  |
Teratogens | 14 | 3 | |
Neocardiogenic | 14 | 11 |  |
Glutathione S-transferase Inhibitor | 14 | 4 | |
Paraptosis | 14 | 14 | |
Anti-collagenase | 13 | 3 | |
Phase I Detoxification Enzyme Inducer | 13 | 7 | |
Glutathione Peroxidase 1 (GPx1) Up-Regulation | 13 | 7 | |
Vascular Endothelial Growth Factor A Enhancer | 13 | 7 | |
Muscle Relaxants: Central | 13 | 4 | |
Leukotriene B4 downregulation | 13 | 4 | |
Carminative | 12 | 2 | |
Insulin Receptor Modulator | 12 | 2 | |
Dopamine Agents | 12 | 2 | |
Mucolytic | 12 | 2 | |
Endocannabinoid down-regulation | 12 | 2 | |
Immunomodulatory: Innate Immunity Up-Regulation | 12 | 2 | |
Mitogen-activated protein kinase inhibitors | 12 | 3 | |
Anti-edemic | 12 | 2 | |
Immunomodulatory: T-Cell down-regulation | 12 | 2 | |
Vasopressin Inhibitor | 12 | 2 | |
Disinfectants | 12 | 3 | |
Interleukin-13 Up-Regulation | 12 | 3 | |
Metallothionein Up-regulation | 12 | 2 | |
VEGFR3 inhibition | 12 | 3 | |
15-Lipoxygenase (15-LOX) Inhibitor | 11 | 8 | |
Interleukin-1 receptor antagonist | 11 | 2 | |
Matrix Metalloproteinase-8 Inhibitor | 11 | 2 | |
Mitogen-activated protein kinase kinase 4 (MEK4) | 11 | 2 | |
Adrenergic alpha-Antagonists | 11 | 2 | |
PI3K/Akt/signaling suppression | 11 | 6 | |
Histamine down-regulation | 11 | 9 | |
Insulinotrophic | 11 | 7 | |
P16 Activation | 11 | 2 | |
Tocolytic Agents | 11 | 2 | |
Immunomodulatory: Immunoglobulin G up-regulation | 10 | 1 | |
NOX2 inhibitor | 10 | 1 | |
PER2 Protein Expression Up-regulation | 10 | 1 | |
Immunomodulatory: Immunoglobulin M Up-Regulation | 10 | 1 | |
Mitochondrial Superoxide Dismutase Upregulation | 10 | 6 | |
Interleukin-3 upregulation | 10 | 1 | |
Glutathione peroxidase 1 (GPx1) inhibitors | 10 | 1 | |
Estrogens | 10 | 1 | |
Intracellular adhesion molecule down-regulation | 10 | 1 | |
Gastric Inhibitory Polypeptide Up-Regulation | 10 | 1 | |
CYP3A enzyme induction | 10 | 1 | |
Interleukin 1 receptor antagonist (IL-1Ra) up-regulation | 10 | 1 | |
Central Nervous System Depressants | 10 | 1 | |
Diacylglyceride acyltransferase 1 (DGAT1) Inhibition | 10 | 1 | |
Oxytocin inducer | 10 | 1 | |
Androgens | 10 | 1 | |
Matrix Metalloproteinases Inhibitors | 10 | 6 | |
Respiratory System Agents | 10 | 1 | |
Neurotransmitter Uptake Inhibitors | 10 | 1 | |
Glucose transporter-2 (GLUT2) expression down-regulation | 10 | 6 | |
Drug sparing | 10 | 1 | |
cAMP up-regulation | 10 | 1 | |
Insulin Antagonists | 10 | 1 | |
Peptide YY (PYY) Down-regulation | 10 | 1 | |
Hormones | 10 | 1 | |
Immunomodulatory: CD23+ Mature Macrophage Down-Regulation | 10 | 1 | |
Glucose transporter-2 (GLUT2) expression up-regulation | 10 | 1 | |
Immunostimulatory: IgA Production Up-Regulation | 10 | 1 | |
Isoprostane Down-Regulation | 10 | 1 | |
Phosphorylase Kinase Inhibitors | 10 | 1 | |
Cannabinoid Receptor Antagonist/Inverse Agonist | 9 | 7 | |
Prostaglandin E Synthase-1 (PGES-1) Down-Regulation | 9 | 3 | |
Redox Modulator | 9 | 5 | |
Analgesics: Opioid | 9 | 6 | |
Excitatory Amino Acid Agonists | 9 | 5 | |
Insulin-mimetic | 9 | 6 | |
Caspase-7 Activation | 9 | 7 | |
Selective estrogen enzyme modulator (SEEM) | 9 | 7 | |
Benzodiazepine receptor agonist | 8 | 6 | |
Vascular Endothelial Growth Factor D Inhibitor | 8 | 4 | |
NADPH Oxidase Inhibitors | 8 | 4 | |
Angiogenesis Modulating Agents | 8 | 5 | |
Enzyme Inhibitors: Pancreatic Amylase | 8 | 6 | |
Thrombolytic | 8 | 5 | |
Monoaminergic | 8 | 4 | |
Selective Estrogen Receptor Modulators | 8 | 5 | |
Acetylcholinesterase Down-Regulation | 7 | 4 | |
ER beta receptor up-regulation | 7 | 5 | |
Insulin-Like Growth Factor Enhancer/Upregulation | 7 | 4 | |
Antigiardial agents | 7 | 4 | |
Intracellular adhesion molecule-1 (ICAM-1) | 7 | 5 | |
Chemotherapeuticm | 7 | 5 | |
HER-2 oncoprotein down-regulation | 7 | 2 | |
Tyrosinase Inhibition | 7 | 5 | |
AKT-mammalian target of rapamycin (mTOR) pathway inhibitor | 6 | 5 | |
E-cadherin down-regulation | 6 | 5 | |
Trypsin Inhibitors | 6 | 4 | |
TRAIL sensitizer | 6 | 5 | |
Bone Density Conservation Agents | 6 | 3 | |
PI3K-AKT inhibitor | 6 | 4 | |
Anti-Arrhythmia Agents | 6 | 4 | |
Caspase-3 Inhibition | 6 | 4 | |
Anti-Estrogenic | 6 | 4 | |
Chemokine (C-C motif) Ligand 2 (CCL2) Down-Regulation | 6 | 4 | |
AMP-activated protein kinase modulation | 6 | 4 | |
Trypanocidal Agents | 6 | 5 | |
Cholinergic Agents | 5 | 3 | |
Cryoprotective Agents | 5 | 4 | |
HIV Fusion Inhibitors | 5 | 4 | |
Protein tyrosine phosphatase 1B (PTP1B) modulator | 5 | 3 | |
Lactate Dehydrogenase A Inhibitor | 5 | 3 | |
Angiotensin II Type 1 Receptor Blockers | 5 | 3 | |
Inhibitor of Nuclear Factor Kappa-B Kinase (IKK) | 5 | 4 | |
Vascular smooth muscle cell (VSMC) inhibitor | 5 | 5 | |
Spermicidal Activity | 5 | 1 | |
Antacids | 5 | 3 | |
Extracellular Signal-Regulated Kinases Modulator | 5 | 4 | |
HMG-CoA reductase inhibitor | 5 | 4 | |
Thromboxane (TXB) Inhibitors | 5 | 4 | |
Dental Disinfectants | 4 | 1 | |
Ghrelin Up-regulation | 4 | 2 | |
Histamine Agents | 4 | 3 | |
Vitamin D Receptor (VDR) Modulator | 4 | 3 | |
Peroxisome Proliferators | 4 | 2 | |
Antiparkinson Agents | 4 | 2 | |
Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Upregulation | 4 | 2 | |
Beta-Endorphin Enhancer | 4 | 2 | |
C-Jun N-Terminal Kinases (JNK) Modulator | 4 | 3 | |
Schistosomicides | 4 | 2 | |
Adrenergic alpha-Agonists | 4 | 3 | |
Immunomodulatory: Regulatory T Cell Up-Regulation | 4 | 2 | |
Tumor Necrosis Factor (TNF) Alpha Upregulation | 4 | 2 | |
Scolicidal | 4 | 4 | |
Erythropoietic | 4 | 3 | |
Anti-Inflammatory Agents: Non-Steroidal | 4 | 2 | |
Paraoxonase down-regulation | 4 | 2 | |
Antipruritics | 4 | 2 | |
Tumor Suppressor Protein p73 Upregulation | 4 | 3 | |
SGLT1 inducer | 4 | 2 | |
Cyclin-dependent kinase inhibitor: P16INK4 | 4 | 3 | |
Metal Chelation: Copper | 4 | 3 | |
Radiation-Protective Agents | 4 | 2 | |
SGLT1 inducer | 4 | 2 | |
Estrogen Receptor Agonist | 3 | 3 | |
p300/NF-κB down-regulation | 3 | 3 | |
Steroidogenesis | 3 | 2 | |
Cholinergic Antagonists | 3 | 2 | |
Antimitotic Agents | 3 | 3 | |
Atrial Natriuretic Factor Modulation | 3 | 2 | |
Beta-Defensin-2 Up-Regulation | 3 | 2 | |
NF-kappa-B-inducing kinase (NIK) modulator | 3 | 2 | |
Anti-Infective Agents: Urinary | 3 | 2 | |
HIV-1 Integrase Inhibitor | 3 | 3 | |
Vanilloid Receptor-1 Modulator | 3 | 3 | |
Cyclin-Dependent Kinase Inhibitor | 3 | 3 | |
Expectorants | 3 | 2 | |
Matrix metalloproteinase-14 (MMP-14) inhibitor | 3 | 3 | |
Quinone Reductase-Inducer | 3 | 2 | |
Adrenergic beta-Agonists | 3 | 2 | |
Estradiol 3-glucuronide enhancer | 3 | 3 | |
Insecticides | 3 | 2 | |
Interleukin-1 alpha upregulation | 3 | 2 | |
P-glycoprotein Inhibitors | 3 | 3 | |
Survival protein down-regulation | 3 | 2 | |
Estradiol Antagonists | 3 | 2 | |
Platelet aggregation inhibitor: collagen-induced aggregation | 3 | 2 | |
Fatty Acid Synthesis Inhibitors | 3 | 3 | |
12-lipoxygenase (12-LOX) Inhibitor | 3 | 2 | |
Forkhead Transcription Factor Family O (FOXO) Modulator | 3 | 2 | |
Contraceptive Agents | 3 | 2 | |
Histamine up-regulation | 3 | 2 | |
Intercellular adhesion molecule 3 down-regulation | 3 | 2 | |
Interleukin-15 downregulation | 3 | 2 | |
Adjuvants: Immunologic | 2 | 1 | |
High-mobility group box-1 (HMGB1) inhibitor | 2 | 1 | |
Bronchoconstrictor Agents | 2 | 1 | |
Uncoupling Agents | 2 | 1 | |
Redox Balancer | 2 | 1 | |
β-secretase Inhibitor | 2 | 2 | |
JAM3 gene down-regulation | 2 | 1 | |
Antifibrinolytic Agents | 2 | 2 | |
Adrenergic Agents | 2 | 1 | |
Carbonic Anhydrase Inhibitors | 2 | 1 | |
Incretin Modulator | 2 | 1 | |
Sarcoplasmic Calcium ATPase Up-regulation | 2 | 1 | |
Ovogenic | 2 | 1 | |
Spasmogenic | 2 | 1 | |
Stomachic | 2 | 1 | |
Hydroperoxidase Inhibitor | 2 | 1 | |
PPAR-Gamma Up-Regulation | 2 | 2 | |
Adrenergic Agonists | 2 | 2 | |
CYP1A1 Transcription Inhibitor | 2 | 1 | |
Histamine Agonists | 2 | 1 | |
Enzyme Inhibitors: Maltase Inhibition | 2 | 1 | |
Serotonin Agents | 2 | 1 | |
Lipotropic Agents | 2 | 1 | |
Central Nervous System Agents | 2 | 1 | |
GSH-Px Up-Regulation | 2 | 1 | |
Muscarinic Agonists | 2 | 1 | |
Serotonin Agonists | 2 | 1 | |
Opioid Endogenous Up-regulation | 2 | 1 | |
Phase I Detoxification Enzyme Inhibitor | 2 | 1 | |
Progestagenic | 2 | 1 | |
Anti-elastase | 2 | 2 | |
Calcium Desensitizer | 2 | 1 | |
Prostaglandin PGF2 downregulation | 2 | 2 | |
RANTES (CCL5) Inhibitor | 2 | 2 | |
Muscarinic Antagonists | 2 | 2 | |
Serum ceruloplasmin oxidase reducer | 2 | 1 | |
Lymphagogue | 2 | 1 | |
Immunologic Factors | 2 | 1 | |
Progesterone receptor (PR) up-regulation | 2 | 1 | |
1-Glutamine Uptake Inhibitor | 2 | 2 | |
Follicle-stimulating hormone receptor (FSHR) up-regulation | 2 | 1 | |
Cicatrizing | 2 | 1 | |
Adenosine Monophosphate (AMP)-Activated Protein Kinase (AMPK) Down-Regulation | 2 | 1 | |
Cyclin-Dependent Kinase Inhibitor: P16 | 2 | 2 | |
Antinitrosation | 2 | 1 | |
Alpha-hemolysin inhibitor | 2 | 2 | |
Arginine Vasopressin (AVP) up-regulation. | 2 | 1 | |
Anthelmintics | 2 | 1 | |
Reactive Oxygen Species (ROS) attenuation | 2 | 2 | |
Interleukin-5 upregulation | 2 | 1 | |
Phosphodiesterase Inhibitors | 2 | 2 | |
Food Preservatives | 2 | 2 | |
Coccidiostats | 2 | 1 | |
Antilipolytic | 2 | 2 | |
Glycine Agents | 2 | 1 | |
Anesthetics | 2 | 1 | |
Histamine H2 Antagonists | 2 | 2 | |
BRCA-1 Downregulation | 2 | 2 | |
Receptor activator of NF-κB (RANK) gene expression | 2 | 2 | |
Myorelaxant | 2 | 1 | |
Neutrophil Activation: Down-Regulation | 2 | 1 |  |
Thromboxane B2 Inhibitor | 2 | 2 | |
Antidiuretic Agents | 2 | 1 | |
Abortifacient Agents | 2 | 1 | |
Akt-dependent HO-1 expression up-regulation | 2 | 1 | |
Death receptor up-regulation | 2 | 1 | |
Arylesterase down-regulation | 2 | 1 | |
Environmental Pollutants | 2 | 1 | |
ER alpha receptor up-regulation | 2 | 1 | |
Breast cancer resistance protein (BCRP) down-regulation | 2 | 2 | |
Receptor-Related Orphan Receptor (ROR)-Alpha1 Inhibitor | 2 | 1 | |
Myosin heavy chain alpha (MHCalpha) reducer | 2 | 1 | |
β(2)-adrenoceptor up-regulation | 2 | 1 | |
Neutrophil Rolling Inhibitor | 2 | 1 | |
Sigma-1 Receptor Agonist | 2 | 2 | |
Noradrenergic | 2 | 1 | |
Stearoyl coenzyme A desaturase-1 modulator | 2 | 1 | |
Human androgen receptor (AR) antagonist | 2 | 2 | |
Leukotriene C4 Downregulation | 2 | 2 | |
Immunomodulatory: CD8+ Up-regulation | 2 | 1 | |
Free Radical Scavengers | 1 | 1 | |
Glucose transporter-5 (GLUT5) expression down-regulation | 1 | 1 | |
Glyoxalase 1 inhibitor | 1 | 1 | |
Astringents | 1 | 1 | |
Anti-Psychotic | 1 | 1 | |
Radiopharmaceuticals | 1 | 1 | |
mTOR/S6K pathway Activator | 1 | 1 | |
S-phase kinase associated protein 2 inhibition | 1 | 1 | |
Serine Proteinase Inhibitors | 1 | 1 | |
Human Polymorphonuclear Leukocyte Degranulation Inhibitor | 1 | 1 | |
Phosphorylated Rb Down-Regulation | 1 | 1 | |
Leukotriene D4 antagonist | 1 | 1 | |
Mast Cell Activation Inhibitor | 1 | 1 | |
17beta-hydroxysteroid dehydrogenase inhibitor | 1 | 1 | |
Akt-SREBP-1 activater | 1 | 1 | |
Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Inhibitor | 1 | 1 | |
Emmenagogue | 1 | 1 | |
Caspase-14 Upregulation | 1 | 1 | |
Prostaglandin H Synthase-1 (PGHS-1) Inhibits | 1 | 1 | |
Chemosterilants | 1 | 1 | |
Hemolytic Agents | 1 | 1 | |
Dopamine Agonists | 1 | 1 | |
Erk/MAP Inactivation | 1 | 1 | |
Caspase-2 Activation | 1 | 1 | |
Carbonyl Reductase 1Inhibitor | 1 | 1 | |
Prostaglandin H Synthase-2 (PGHS-2) Up-Regulation | 1 | 1 | |
Oxidants | 1 | 1 | |
Palmitoylation Inhibitors | 1 | 1 | |
Sulfonation | 1 | 1 | |
Hydroxyheptadecatrienoate (HHT) Inhibitor | 1 | 1 | |
IGF-1R expression down-regulation | 1 | 1 | |
PRL-3 Down-Regulation | 1 | 1 | |
5-HTergic | 1 | 1 | |
Cyclin-Dependent Kinase 4 Down-Regulation | 1 | 1 | |
Dopamine Antagonists | 1 | 1 | |
Endocannabinoid Modulator | 1 | 1 | |
Eryptotic | 1 | 1 | |
Psychedelic | 1 | 1 | |
RANK Downregulation | 1 | 1 | |
Oxytocics | 1 | 1 | |
5-Hydroxyeicosatetraenoic acid (5-HETE) Inhibitor | 1 | 1 | |
Chymotrypsin Inhibitor | 1 | 1 | |
Dopamine Receptor D3 Antagonist | 1 | 1 | |
Arginase 1 (Arg1) up-regulation | 1 | 1 | |
Brain-Associated Sulfotransferase Down-Regulation | 1 | 1 | |
Molecular Probes | 1 | 1 | |
Neovasculogenesis | 1 | 1 | |
Ionophores | 1 | 1 | |
Superoxide Scavenger | 1 | 1 | |
Antidepressive Agents: Second-Generation | 1 | 1 | |
Dipeptidyl-Peptidase IV Inhibitors | 1 | 1 | |
Enkephalinase inhibitor | 1 | 1 | |
EpCAM surface marker down-regulation | 1 | 1 | |
Calcium/calmodulin dependent protein kinase II inhibitor | 1 | 1 | |
Matrix metalloproteinase-16 (MMP-16) inhibitor | 1 | 1 | |
Secretagogues: Prolactin Up-Regulation | 1 | 1 | |
Nonpeptidyl Inhibitors | 1 | 1 | |
IRAK-MAPK Modulator | 1 | 1 | |
PKM2 downregulation | 1 | 1 | |
Transient Receptor Potential Melastatin 2 Inhibition | 1 | 1 | |
Antibiotics: Antifungal | 1 | 1 | |
1-Leucine Uptake Inhibitor | 1 | 1 | |
Air Pollutants: Radioactive | 1 | 1 | |
Cytotoxins | 1 | 1 | |
Aminopeptidase N (APN/CD13) inhibitor | 1 | 1 | |
Hematologic Agents | 1 | 1 | |
Apaf-1/caspase-dependent apoptotic pathway activator | 1 | 1 | |
Enoyl-acyl Carrier Protein (ACP) Reductase Inhibitors | 1 | 1 | |
Matrix metalloproteinase-17 (MMP-17) inhibitor | 1 | 1 | |
Zinc-dependent metalloproteinase inhibitor | 1 | 1 | |
STAT3-NFκB Signaling: downregulation | 1 | 1 | |
Phospholipase D Inhibitors | 1 | 1 | |
Hypomethylating | 1 | 1 | |
Transient receptor potential vanilloid type-2 activation | 1 | 1 | |
Herbicides | 1 | 1 | |
Estrogen Antagonists | 1 | 1 | |
Cancerous inhibitor of protein phosphatase 2A inhibitor | 1 | 1 | |
Protein Kinase C Inhibitor | 1 | 1 | |
Radiation-Sensitizing Agents | 1 | 1 | |
Ribonucleotide Reductase Inhibitor | 1 | 1 | |
Neuroimmunomodulation | 1 | 1 |  |
Maspin (Protease Inhibitor) Up-Regulation | 1 | 1 | |
Hepatoma-derived growth factor (HDGF) inhibitor | 0 | 1 | |