Natural Health Research Discovery

Each Topic is an Index of Curated Biomedical Research Abstracts

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Pharmacological Actions

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Pharmacological Actions (501)

ALLA B C D E F G H I J L M N O P Q R S T U V W X Z Β
Pharmacological Action NameCumulative Knowledgesort iconAbstractsPDF
Antioxidants215288856Downloadable Document
Anti-Inflammatory Agents208598334Downloadable Document
Neuroprotective Agents104044396Downloadable Document
Apoptotic69865304Downloadable Document
Antiproliferative68015032Downloadable Document
Tumor Necrosis Factor (TNF) Alpha Inhibitor67362815Downloadable Document
Cardioprotective53771675Downloadable Document
Chemopreventive53741717Downloadable Document
Hypoglycemic Agents53661338Downloadable Document
Hypolipidemic53581221Downloadable Document
Hepatoprotective50982264Downloadable Document
Interleukin-6 Downregulation50291994Downloadable Document
Antidepressive Agents4882874Downloadable Document
Antihypertensive Agents4527683Downloadable Document
Immunomodulatory40481475Downloadable Document
NF-kappaB Inhibitor35362098Downloadable Document
Analgesics3498646Downloadable Document
Gastrointestinal Agents3145843
Anticholesteremic Agents3078530Downloadable Document
Interleukin-1 beta downregulation30411567Downloadable Document
Anti-Anxiety Agents2913487
Anti-Apoptotic29051672Downloadable Document
Anti-Bacterial Agents28941251Downloadable Document
Renoprotective24041075Downloadable Document
Chemotherapeutic23281086
Chemoprotective Agents2322906
Malondialdehyde Down-regulation2065678Downloadable Document
Anti-metastatic19721481Downloadable Document
Antiviral Agents19571034Downloadable Document
Anticarcinogenic Agents1890889Downloadable Document
Antineoplastic Agents18471170Downloadable Document
Cell cycle arrest16781348Downloadable Document
Radioprotective1668521Downloadable Document
Cyclooxygenase 2 Inhibitors1589926Downloadable Document
Nrf2 activation1584916
Superoxide Dismutase Up-regulation1403551Downloadable Document
Antimicrobial1209582Downloadable Document
Insulin Sensitizers1185244Downloadable Document
Chemosensitizer1124854Downloadable Document
MicroRNA modulator1023618
Osteoprotective971351
Gastroprotective955388Downloadable Document
Anti-Fibrotic924463Downloadable Document
Matrix metalloproteinase-9 (MMP-9) inhibitor786505Downloadable Document
Prophylactic Agents780182
Matrix metalloproteinase-2 (MMP-2) inhibitor727442Downloadable Document
Enzyme Inhibitors692347Downloadable Document
Anticonvulsants678189Downloadable Document
Cytoprotective659326
Antinoceceptive647197Downloadable Document
Detoxifier644202Downloadable Document
Immunostimulatory633192Downloadable Document
Vasodilator Agents626169Downloadable Document
Heme oxygenase-1 up-regulation624373
Tumor Suppressor Protein p53 Upregulation585431Downloadable Document
Interleukin-8 downregulation581231Downloadable Document
Bcl-2 protein down-regulation553407Downloadable Document
Anti-Ulcer Agents523184Downloadable Document
Autophagy Up-regulation518349Downloadable Document
Nitric Oxide Inhibitor498258Downloadable Document
Antifungal Agents494306Downloadable Document
Angiogenesis Inhibitors488296
Genoprotective477177Downloadable Document
Anxiolytic47566Downloadable Document
Hypotensive46763Downloadable Document
Brain-derived neurotrophic factor modulator458166
Photoprotective446198
Anti-Allergic Agents442150Downloadable Document
Antidiarrheals43987
Vascular Endothelial Growth Factor Inhibitors435247
Regenerative408172
Pancreato Protective Agents358194
Interleukin-4 downregulation355128Downloadable Document
Anti-atherogenic348120
Anti-Angiogenic347234Downloadable Document
Interleukin-10 downregulation335128Downloadable Document
Glutathione Upregulation29996Downloadable Document
Radiosensitizer291182Downloadable Document
Anti-Asthmatic Agents28671
Alpha-glucosidase inhibitor274201Downloadable Document
Dermatologic Agents27232Downloadable Document
Catalase Up-Regulation264112
Nitric Oxide Enhancer26176Downloadable Document
Telomere Protective23129
Adiponectin upregulation21739
Neurogenesis215109
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor214142
Antiparasitic Agents208121Downloadable Document
Wnt/β-catenin signaling pathway modulation208149
Vasoprotective20752
Uricosuric Agents20544
Transforming growth factor beta (TGF-β) inhibitor203106
Postaglandin PGE2 downregulation202110
Cardiovascular Agents20132Downloadable Document
Platelet Aggregation Inhibitors20045Downloadable Document
Anti-Glycation Agents197100
Interleukin-17 downregulation19385
Prostaglandin PGE2 downregulation19388Downloadable Document
Neuritogenic18589Downloadable Document
Vascular Endothelial Growth Factor A Inhibitor17997Downloadable Document
Secretagogue17838Downloadable Document
Immunomodulatory: Th17 downregulation17781
Alpha-amylase inhibitor175110
Autophagy Inhibitors175115
Acetylcholinesterase Inhibitor17095Downloadable Document
Matrix metalloproteinase-3 (MMP-3) inhibitor16968
Antimutagenic Agents16499Downloadable Document
Anti-Adipogenic16485Downloadable Document
P21 Activation160119
Anti-Tumor15476Downloadable Document
Matrix Metalloproteinase-13 (MMP-13) Inhibitor14566
Antispasmodic14037Downloadable Document
Interleukin-12 downregulation13953
Caspase-3 Activation13790Downloadable Document
Telomerase Upregulation13734Downloadable Document
Anti-Platelet13747Downloadable Document
Anti-HIV Agents13384Downloadable Document
Interleukin-18 down-regulation13261
Glucagon Like peptide 1 (GLP-1) Up-regulation12935Downloadable Document
Heat Shock Protein Inducer12648Downloadable Document
Interleukin-2 Downregulation12351
Vascular Cell Adhesion Molecule-1 Inhibitor12334Downloadable Document
Insulin-releasing12249Downloadable Document
Interleukin-5 downregulation12049
Leishmanicidal11879Downloadable Document
Interleukin-4 upregulation11342
Cyclin D1 Down-Regulation10679
Cardiotonic Agents10610
Interleukin-10 upregulation10524
Interleukin-1 alpha downregulation10242Downloadable Document
Angiotensin-Converting Enzyme Inhibitors9954Downloadable Document
Matrix metalloproteinase-1 (MMP-1) inhibitor9959
Calcium Channel Blockers9829Downloadable Document
Histone deacetylase inhibitor9869Downloadable Document
Phase II Detoxification Enzyme Inducer9552Downloadable Document
Telomerase Inhibitor9562Downloadable Document
DNA Repair Up-regulation9327
Antimalarials9053Downloadable Document
Fertility Agents: Female9018
interleukin-13 down-regulation9047
Angiogenesis Inducing Agents8845
Epidermal growth factor receptor (EGFR) inhibitor8760Downloadable Document
Insulin-Like Growth Factor Inhibition/Downregulation8618Downloadable Document
Neuroplasticity enhancement8323
Immunosuppressive Agents8043Downloadable Document
Anti-Cachexic Agents7926
Bronchodilator Agents7815Downloadable Document
Cytotoxic7660
Anti-thrombotic7632Downloadable Document
Cyclooxygenase Inhibitors7442Downloadable Document
Galactogogue738
Neurorestorative7121Downloadable Document
Caspase-9 Activation7046
Xanthine oxidase inhibitor6934Downloadable Document
NF-E2-Related Factor-2 (Nrf2) Modulator6939
Anti-Proliferative6755Downloadable Document
Aphrodisiac6722Downloadable Document
Anti-Infective Agents6640
Cyclooxygenase 1 Inhibitor6548Downloadable Document
Appetite Suppresant6414
Ergogenic638
Vascular Endothelial Growth Factor Regulator6229Downloadable Document
Malonaldehyde (MDA) Down-Regulation6215
Anti-pyretic6224
Antiprotozoal Agents6132
Antiemetics605
Interferon-gamma (IFN-gamma) inducer6018
Fertility Agents: Male6014
Proteasome Inhibitors5940Downloadable Document
Interferon Gamma Reducer5824
Estrogen Receptor Modulators5834Downloadable Document
Thermogenic579
Heme oxygenase-1 inducer5739
Serotonergic5612
Diuretics5514Downloadable Document
Cholagogues and Choleretics5412Downloadable Document
STAT3 Inhibitor5331
Osteogenic5212
Interleukin-2 upregulation5113
Lipoxygenase Inhibitors5027Downloadable Document
Lipolytic4918Downloadable Document
Quorum Sensing Inhibition4949
Anti-Retroviral Agents4918
Interleukin-12 upregulation4813
Reverse Transcriptase Inhibitors4729Downloadable Document
Enzyme Inhibitors: Pancreatic Lipase4619
Histamine Antagonists4517Downloadable Document
Aromatase Inhibitors4533Downloadable Document
Histamine Antagonists4517Downloadable Document
GABA Modulators4417
Tumor Necrosis Factor (TNF) Alpha Enhancer4413
Laxative426
Appetite Depressants429
Heat Shock Protein Down-Regulation4222
Interferon Inducers4110
Chelating Agents4121
Bax/Bcl2 ratio: Increase4032
Iron Chelating Agents4015
Appetite Stimulants398
SIRT1 Activator3923
Insulin Down-Regulation387
Leukotriene Antagonists389
Ghrelin Down-Regulation366
Glucagon Like Peptide 1 (GLP-1) Down-Regulation356
Analgesics: Non-Narcotic3510
Bcl-xL down-regulation3526
Antimycobacterial3519Downloadable Document
5-Lipoxygenase Inhibitor3521
Spermatogenic3412
Uterotonic3411Downloadable Document
Cholecystokinin (CCK) Up-regulation345
Photosensitizing Agents3215
Caspase-8 activation3222
Dopaminergic3210Downloadable Document
Cholinesterase Inhibitors3223
Transforming growth factor beta (TGF-β) upregulation3214
Aldose reductase inhibitor329
Interleukin-6 upregulation3211
HIV Protease Inhibitors3119Downloadable Document
Antiurolithiatic319
Carcinogens312
Interleukin-8 upregulation303
Protein Kinase Inhibitors2919Downloadable Document
Bax/Bcl2 Ratio: Decrease2918
Enzyme Activators2918
Prostaglandin Antagonists2713Downloadable Document
Adiponectin Down-Regulation278
Glucose Uptake Optimization269
Detoxifier: Radionuclide Removal255
Androgen Antagonists255
Interleukin-22 Downregulation2410
Monocyte chemotattractant protein-1 (MCP-1) Inhibitor234
Natriuretic Agents234
Leptin Down-Regulation238
Viral Hemagglutinin Inhibitor2216Downloadable Document
Chymotrypsin Inhibitor212
Gluconeogenesis Inhibitor2115Downloadable Document
Fibroblast growth factor 21 upregulation2111
Hypnotics and Sedatives206
Adenosine deaminase inhibitor207
Hematopoietic209
Neurominidase Inhibitor2019Downloadable Document
Cholecystokinin Releaser202
Topoisomerase II Inhibitor1917
Anticoagulants1815
P38 Mitogen-Activated Protein Kinase Modulator1611
Peptide YY (PYY) Up-Regulation164
Antioxidant Effects154
Antitubercular Agents155
Survivin Down-Regulation1513
Antipsychotic Agents152
Hepatocyte growth factor (HGF) inhibitor154
Protease Inhibitors156
Teratogens143
Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor144
Paraptosis1414
Cell Differentiation Inducer1411
Matrix Metalloproteinase-12 (MMP-12) Inhibitor137
Anti-collagenase132
Leukotriene B4 downregulation134
Topoisomerase I inhibitor1311
Anti-edemic122
Insulin Receptor Modulator122
Mucolytic122
Vasopressin Inhibitor122
Endocannabinoid down-regulation122
Immunomodulatory: T-Cell down-regulation122
Carminative122
Dopamine Agents122
VEGFR3 inhibition123
Insulinotrophic117
Interleukin-1 receptor antagonist112
Mitogen-activated protein kinase inhibitors112
Mitogen-activated protein kinase kinase 4 (MEK4)112
Respiratory System Agents101
Immune Enhancing Properties101
Insulin Antagonists101
Fatty Acid Oxidation101
Glutathione peroxidase 1 (GPx1) inhibitors101
Interleukin-3 upregulation101
Intracellular adhesion molecule down-regulation101
Immunostimulatory: IgA Production Up-Regulation101
Matrix Metalloproteinases Inhibitors106
Drug sparing101
Immunomodulatory: CD23+ Mature Macrophage Down-Regulation101
Diacylglyceride acyltransferase 1 (DGAT1) Inhibition101
Neurotransmitter Uptake Inhibitors101
Gastric Inhibitory Polypeptide Up-Regulation101
Hormones101
NOX2 inhibitor101
Oxytocin inducer101
Immunomodulatory: Immunoglobulin G up-regulation101
Interleukin 1 receptor antagonist (IL-1Ra) up-regulation101
Peptide YY (PYY) Down-regulation101
Alkylating Agents101
STAT3 Activation108
Antilipemic Agents101
Isoprostane Down-Regulation101
Phosphorylase Kinase Inhibitors101
Interleukin-13 Up-Regulation101
cAMP up-regulation101
PER2 Protein Expression Up-regulation101
Interleukin-23 Downregulation101
Cannabinoid Receptor Antagonist/Inverse Agonist97
Redox Modulator95
Analgesics: Opioid96
Insulin-mimetic96
Benzodiazepine receptor agonist86
Insecticidal84
Adenosine Monophosphate (AMP)-activated Protein Kinase (AMPK72
Prostaglandin E Synthase-1 (PGES-1) Down-Regulation72
Vascular smooth muscle cell (VSMC) inhibitor75
Antigiardial agents74
Excitatory Amino Acid Agonists74
Monoaminergic63
AMP-activated protein kinase modulation64
Interleukin-18 upregulation64
Trypsin Inhibitors64
Interleukin-21 downregulation63
5-Lipoxygenase Inhibitor65
HIV Fusion Inhibitors54
HMG-CoA reductase inhibitor54
Insulin-Like Growth Factor Enhancer/Upregulation53
Antacids51
Spermicidal Activity51
Extracellular Signal-Regulated Kinases Modulator54
Antithrombotic42
Adrenergic alpha-Agonists43
Monoamine Oxidase Inhibitors42
SGLT1 inducer42
Phase I Detoxification Enzyme Inducer42
Ghrelin Up-regulation42
Contraceptive Agents: Male42
Intracellular adhesion molecule-1 (ICAM-1)43
Erythropoietic43
Angiotensin II Type 1 Receptor Blockers42
Schistosomicides42
Anticholinergic42
Mitochondrial Superoxide Dismutase Upregulation43
Thrombolytic42
Immunomodulatory: Regulatory T Cell Up-Regulation42
Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Upregulation42
Matrix Metalloproteinase-7 (MMP-7) Inhibitor41
Vascular Endothelial Growth Factor A Enhancer42
Anti-Inflammatory Agents: Non-Steroidal42
Steroidogenesis32
Chemokine (C-C motif) Ligand 2 (CCL2) Down-Regulation32
Cholinergic Agents32
Forkhead Transcription Factor Family O (FOXO) Modulator32
TRAIL sensitizer32
Adrenergic beta-Agonists32
Cholinergic Antagonists32
Antimitotic Agents33
Quinone Reductase-Inducer32
Platelet aggregation inhibitor: collagen-induced aggregation32
Estradiol 3-glucuronide enhancer33
Survival protein down-regulation32
Glucose transporter-2 (GLUT2) expression down-regulation32
Cyclin-Dependent Kinase Inhibitor33
Histamine down-regulation32
Atrial Natriuretic Factor Modulation32
NF-kappa-B-inducing kinase (NIK) modulator32
Matrix metalloproteinase-8 (MMP-8) inhibitor32
Interleukin-15 downregulation32
Progesterone receptor (PR) up-regulation21
RANTES (CCL5) Inhibitor22
Myorelaxant21
Serum ceruloplasmin oxidase reducer21
Antidiuretic Agents21
Peroxisome Proliferators21
Vascular Endothelial Growth Factor C Inhibitor21
Reactive Oxygen Species (ROS) attenuation22
Bronchoconstrictor Agents21
Myosin heavy chain alpha (MHCalpha) reducer21
Stomachic21
Ovogenic21
1-Glutamine Uptake Inhibitor22
Environmental Pollutants21
Histamine Agents21
Akt-dependent HO-1 expression up-regulation21
Angiogenesis Modulating Agents21
Receptor-Related Orphan Receptor (ROR)-Alpha1 Inhibitor21
Sigma-1 Receptor Agonist22
Nootropic Agents21
Phase I Detoxification Enzyme Inhibitor21
Lymphagogue21
Fertility Agents21
Glycine Agents21
Histamine Agonists21
Uncoupling Agents21
AKT-mammalian target of rapamycin (mTOR) pathway inhibitor22
Arginine Vasopressin (AVP) up-regulation.21
Redox Balancer21
C-Jun N-Terminal Kinases (JNK) Modulator22
Noradrenergic21
Antiparkinson Agents21
Adenosine Monophosphate (AMP)-Activated Protein Kinase (AMPK) Down-Regulation21
Immunomodulatory: CD8+ Up-regulation21
Incretin Modulator21
Neutrophil Activation: Down-Regulation21
Enzyme Inhibitors: Maltase Inhibition21
Inhibitor of Nuclear Factor Kappa-B Kinase (IKK)22
Human androgen receptor (AR) antagonist22
Muscarinic Agonists21
Calcium Desensitizer21
P-glycoprotein Inhibitors22
Cicatrizing21
Thromboxane B2 Inhibitor22
Adjuvants: Immunologic21
Remyelination21
Muscarinic Antagonists22
Central Nervous System Agents21
Opioid Endogenous Up-regulation21
Coccidiostats21
Antinitrosation21
Leukotriene C4 Downregulation22
Follicle-stimulating hormone receptor (FSHR) up-regulation21
Gene Protective21
GSH-Px Up-Regulation21
Cyclin-Dependent Kinase Inhibitor: P1622
Death receptor up-regulation21
Hydroperoxidase Inhibitor21
Adrenergic Agents21
Progestagenic21
Anesthetics21
Serotonin Agonists21
JAM3 gene down-regulation21
Abortifacient Agents21
Endothelin-1 Inhibitor21
ER beta receptor up-regulation21
Insecticides21
Food Preservatives22
Tumor Necrosis Factor (TNF) Alpha Upregulation21
Matrix Metalloproteinase-8 Inhibitor11
Breast cancer resistance protein (BCRP) down-regulation11
Cancerous inhibitor of protein phosphatase 2A inhibitor11
Antibiotics: Antifungal11
p300/NF-κB down-regulation11
Lactate Dehydrogenase A Inhibitor11
Dopamine Agonists11
Enkephalinase inhibitor11
Herbicides11
Alpha-hemolysin inhibitor11
PI3K/Akt/signaling suppression11
Vitamin D Receptor (VDR) Modulator11
Eryptotic11
Fatty Acid Synthesis Inhibitors11
Hematologic Agents11
Tyrosinase Inhibition11
Matrix metalloproteinase-14 (MMP-14) inhibitor11
Arginase 1 (Arg1) up-regulation11
Psychedelic11
S-phase kinase associated protein 2 inhibition11
Carbonyl Reductase 1Inhibitor11
Sulfonation11
Oxidants11
Antifibrinolytic Agents11
Palmitoylation Inhibitors11
17beta-hydroxysteroid dehydrogenase inhibitor11
PKM2 downregulation11
Cryoprotective Agents11
Matrix metalloproteinase-17 (MMP-17) inhibitor11
mTOR/S6K pathway Activator11
Neovasculogenesis11
Oxytocics11
Chondroprotective11
Ionophores11
5-HTergic11
Hypomethylating11
E-cadherin down-regulation11
Transient Receptor Potential Melastatin 2 Inhibition11
Dipeptidyl-Peptidase IV Inhibitors11
Akt-SREBP-1 activater11
Prostaglandin H Synthase-1 (PGHS-1) Inhibits11
Superoxide Scavenger11
IRAK-MAPK Modulator11
5-Hydroxyeicosatetraenoic acid (5-HETE) Inhibitor11
Phosphodiesterase Inhibitors11
Emmenagogue11
Zinc-dependent metalloproteinase inhibitor11
Estrogen Antagonists11
Glyoxalase 1 inhibitor11
Cyclin-Dependent Kinase 4 Down-Regulation11
Disinfectants11
Maspin (Protease Inhibitor) Up-Regulation11
Prostaglandin H Synthase-2 (PGHS-2) Up-Regulation11
Astringents11
Serine Proteinase Inhibitors11
Phospholipase D Inhibitors11
β-secretase Inhibitor11
Insect Repellents11
Hemolytic Agents11
Cytotoxins11
Human Polymorphonuclear Leukocyte Degranulation Inhibitor11
PPAR-Gamma Up-Regulation11
Mast Cell Activation Inhibitor11
Beta-Defensin-2 Up-Regulation11
Calcium/calmodulin dependent protein kinase II inhibitor11
Neuroimmunomodulation11
P16 Activation11
Hypoxia-inducible factor-1 (HIF-1) inhibitor11
Endocannabinoid Modulator11
Glucose transporter-5 (GLUT5) expression down-regulation11
Histamine up-regulation11
RANK Downregulation11
Molecular Probes11
Muscle Relaxants: Central11
Anti-cancer11
Contraceptive Agents11
Antilipolytic11
Leukotriene D4 antagonist11
IGF-1R expression down-regulation11
Interleukin-1 beta upregulation11
Cyclin-dependent kinase inhibitor: P16INK411
Hydroxyheptadecatrienoate (HHT) Inhibitor11

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