Focused Research Topics Garlic & Colon Cancer

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Associated Topics included in this Focused Research

Allicin Garlic

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10 Research Articles in Total

Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer.

Pubmed Data : J Nutr. 2006 Mar;136(3 Suppl):816S-820S. PMID: 16484572
Article Published Date : Mar 01, 2006
Authors : Hideki Ishikawa, Tomoko Saeki, Toru Otani, Takaichiro Suzuki, Kojiro Shimozuma, Hoyoku Nishino, Sanae Fukuda, Kanehisa Morimoto
Study Type : Human Study
Additional Links
Substances : Garlic : CK(2192) : AC(726)
Diseases : Colon Cancer : CK(1887) : AC(1180), Liver Cancer : CK(3026) : AC(1607), Low Immune Function: Natural Killer Cells : CK(121) : AC(24), Pancreatic Cancer : CK(1504) : AC(556)
Additional Keywords : Drug Side Effect Attenuation : CK(251) : AC(49), Plant Extracts : CK(18030) : AC(6686)

Allicin, the major ingredient of freshly crushed garlic, inhibits cancer cell proliferation.

Pubmed Data : Nutr Cancer. 2000;38(2):245-54. PMID: 11525603
Article Published Date : Jan 01, 2000
Authors : K Hirsch, M Danilenko, J Giat, T Miron, A Rabinkov, M Wilchek, D Mirelman, J Levy, Y Sharoni
Study Type : In Vitro Study
Additional Links
Substances : Allicin : CK(360) : AC(196), Garlic : CK(2192) : AC(726)
Diseases : Breast Cancer : CK(7730) : AC(2941), Colon Cancer : CK(1887) : AC(1180), Endometrial Cancer : CK(512) : AC(124)
Pharmacological Actions : Antiproliferative : CK(9389) : AC(7261), Apoptotic : CK(9052) : AC(7187), Cell cycle arrest : CK(2100) : AC(1696)
Additional Keywords : Plant Extracts : CK(18030) : AC(6686)

This review outlines the anticancer role of allicin in each hallmark of cancer.

Pubmed Data : Molecules. 2024 Mar 15 ;29(6). Epub 2024 Mar 15. PMID: 38542956
Article Published Date : Mar 14, 2024
Authors : Wamidh H Talib, Media Mohammed Baban, Aya O Azzam, Jenan J Issa, Alaa Y Ali, Alia Kh AlSuwais, Sana Allala, Lina T Al Kury
Study Type : Review
Additional Links
Substances : Garlic : CK(2192) : AC(726)
Diseases : Colon Cancer : CK(1887) : AC(1180)
Pharmacological Actions : Antineoplastic Agents : CK(2184) : AC(1428)
Additional Keywords : Plant Extracts : CK(18030) : AC(6686)

Allicin purified from fresh garlic cloves induces programmed cell death in colon cancer cells.

Pubmed Data : Nutr Cancer. 2010;62(7):947-57. PMID: 20924970
Article Published Date : Jan 01, 2010
Authors : Wolf Bat-Chen, Tal Golan, Irena Peri, Zvi Ludmer, Betty Schwartz
Study Type : In Vitro Study
Additional Links
Substances : Allicin : CK(360) : AC(196)
Diseases : Colon Cancer : CK(1887) : AC(1180)
Pharmacological Actions : Antiproliferative : CK(9389) : AC(7261), Apoptotic : CK(9052) : AC(7187), NF-E2-Related Factor-2 (Nrf2) Modulator : CK(72) : AC(41)

Diallyl disulfide (DADS), a major organosulfur compound of garlic oil, is capable of inhibiting colon cancer cells.

Pubmed Data : Oncol Rep. 2008 Jan;19(1):275-80. PMID: 18097607
Article Published Date : Jan 01, 2008
Authors : Hong Jae Jo, Ju Dong Song, Kang Mi Kim, Yong Hoon Cho, Ki Hyung Kim, Young Chul Park
Study Type : In Vitro Study
Additional Links
Substances : Garlic : CK(2192) : AC(726)
Diseases : Colon Cancer : CK(1887) : AC(1180)
Pharmacological Actions : Antineoplastic Agents : CK(2184) : AC(1428), Antiproliferative : CK(9389) : AC(7261), Tumor Suppressor Protein p53 Upregulation : CK(741) : AC(543)

These findings indicate that Z-ajoene from garlic may be a potential chemotherapeutic agent.

Pubmed Data : Molecules. 2020 Feb 6 ;25(3). Epub 2020 Feb 6. PMID: 32041324
Article Published Date : Feb 05, 2020
Authors : Hua Li, Ji Hye Jeong, Sung Won Kwon, Sang Kook Lee, Hwa Jin Lee, Jae-Ha Ryu
Study Type : In Vitro Study
Additional Links
Substances : Garlic : CK(2192) : AC(726)
Diseases : Colon Cancer : CK(1887) : AC(1180)
Pharmacological Actions : Antiproliferative : CK(9389) : AC(7261), Chemotherapeutic : CK(3530) : AC(1475), Wnt/β-catenin signaling pathway modulation : CK(303) : AC(216)

High temperature- and pressure-treated garlic inhibits chemically-induced precancerous cellular changes in the rat colon.

Pubmed Data : Asian Pac J Cancer Prev. 2009;10(5):827-31. PMID: 20104973
Article Published Date : Jan 01, 2009
Authors : Takeshi Chihara, Kan Shimpo, Takaaki Kaneko, Hidehiko Beppu, Akiko Tomatsu, Shigeru Sonoda
Study Type : Animal Study
Additional Links
Substances : Garlic : CK(2192) : AC(726)
Diseases : Colon Cancer : CK(1887) : AC(1180)
Pharmacological Actions : Chemopreventive : CK(6381) : AC(2130)

Cost effective use of a thiosulfinate-enriched Allium sativum extract in combination with chemotherapy in colon cancer.

Pubmed Data : Int J Mol Sci. 2020 Apr 16 ;21(8). Epub 2020 Apr 16. PMID: 32316312
Article Published Date : Apr 15, 2020
Authors : Jose Manuel Perez-Ortiz, Eva Maria Galan-Moya, Miguel Angel de la Cruz-Morcillo, Juan Francisco Rodriguez, Ignacio Gracia, Maria Teresa Garcia, Francisco Javier Redondo-Calvo
Study Type : In Vitro Study
Additional Links
Substances : Garlic : CK(2192) : AC(726)
Diseases : Colon Cancer : CK(1887) : AC(1180)
Pharmacological Actions : Chemosensitizer : CK(1613) : AC(1243), Chemotherapeutic : CK(3530) : AC(1475)
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil : CK(237) : AC(164), Chemotherapeutic Synergy: Oxaliplatin : CK(72) : AC(48)

Diallyl disulfide inhibits colon cancer metastasis.

Pubmed Data : Onco Targets Ther. 2019 ;12:5713-5728. Epub 2019 Jul 16. PMID: 31410018
Article Published Date : Dec 31, 2018
Authors : Longzheng Xia, Jingguan Lin, Jian Su, Linda Oyang, Heran Wang, Shiming Tan, Yanyan Tang, Xiaoyan Chen, Wenbin Liu, Xia Luo, Yutong Tian, Jiaxin Liang, Qi Su, Qianjin Liao, Yujuan Zhou
Study Type : In Vitro Study
Additional Links
Substances : Garlic : CK(2192) : AC(726), Organosulfur Compounds : CK(2174) : AC(1019)
Diseases : Colon Cancer : CK(1887) : AC(1180)
Pharmacological Actions : Anti-metastatic : CK(2809) : AC(2129)

A garlic extract, Diallyl disulfide, modulates gene expression in colon cells, inhibiting tumorigenesis.

Pubmed Data : Carcinogenesis. 2004 Jul;25(7):1227-36. Epub 2004 Feb 19. PMID: 14976134
Article Published Date : Jul 01, 2004
Authors : Nathalie Druesne, Anthony Pagniez, Camille Mayeur, Muriel Thomas, Claire Cherbuy, Pierre-Henri Duée, Paule Martel, Catherine Chaumontet
Study Type : In Vitro Study
Additional Links
Substances : Garlic : CK(2192) : AC(726)
Diseases : Colon Cancer : CK(1887) : AC(1180)
Additional Keywords : Epigenetic Modification : CK(533) : AC(203), Histone Acetylation : CK(2) : AC(2)

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