Focused Research Topics Turmeric & Alzheimer's Disease

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Associated Topics included in this Focused Research

Curcumin Curcuminoids Curcumol Demethoxycurcumin Tetrahydrocurcumin Turmeric Turmerones

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97 Research Articles in Total

Benefits of curcumin in brain disorders.

Pubmed Data : Biofactors. 2019 Sep ;45(5):666-689. Epub 2019 Jun 11. PMID: 31185140
Article Published Date : Aug 31, 2019
Authors : Abid Bhat, Arehally M Mahalakshmi, Bipul Ray, Sunanda Tuladhar, Tousif A Hediyal, Esther Manthiannem, Jagadeeswari Padamati, Ramesh Chandra, Saravana B Chidambaram, Meena K Sakharkar
Study Type : Review
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Amyotrophic Lateral Sclerosis : CK(746) : AC(188), Anxiety : CK(3360) : AC(595), Autism Spectrum Disorders : CK(3347) : AC(486), Dementia : CK(1689) : AC(279), Depression : CK(6233) : AC(1096), Depression : CK(6233) : AC(1096), Huntington Disease : CK(188) : AC(78), Multiple Sclerosis : CK(1802) : AC(394), Parkinson's Disease : CK(1838) : AC(659), Stroke : CK(2862) : AC(421)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Antioxidants : CK(21528) : AC(8856), Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin and Apigenin might delay the onset of Alzheimer's disease or slow down its progression.

Pubmed Data : Neural Regen Res. 2015 Aug ;10(8):1181-5. PMID: 26487830
Article Published Date : Jul 31, 2015
Authors : Madhuri Venigalla, Erika Gyengesi, Gerald Münch
Study Type : Review
Additional Links
Substances : Apigenin : CK(432) : AC(251), Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Brain Inflammation : CK(1101) : AC(567)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin attenuated neurotoxicity in sporadic animal model of Alzheimer's disease.

Pubmed Data : Molecules. 2021 May 18 ;26(10). Epub 2021 May 18. PMID: 34070220
Article Published Date : May 17, 2021
Authors : Ines ELBini-Dhouib, Raoudha Doghri, Amenallah Ellefi, Imen Degrach, Najet Srairi-Abid, Asma Gati
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Anti-Apoptotic : CK(2905) : AC(1672), Anti-Inflammatory Agents : CK(20859) : AC(8334), Antioxidants : CK(21528) : AC(8856), Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin may be a promising pharmacological candidate for neurodegenerative diseases.

Pubmed Data : PLoS One. 2016 ;11(1):e0147721. Epub 2016 Jan 29. PMID: 26824354
Article Published Date : Dec 31, 2015
Authors : Gen-Lin He, Zhen Luo, Ju Yang, Ting-Ting Shen, Yi Chen, Xue-Sen Yang
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Neurodegenerative Diseases : CK(8689) : AC(2653)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Prostaglandin PGE2 downregulation : CK(193) : AC(88)

Curcumin may protect against amyloid-beta-stimulated inflammation associated wtih Alzheimer disease.

Pubmed Data : J Alzheimers Dis. 2010;20(4):1189-99. PMID: 20413894
Article Published Date : Jan 01, 2010
Authors : Hong-Mei Wang, Yan-Xin Zhao, Shi Zhang, Gui-Dong Liu, Wen-Yan Kang, Hui-Dong Tang, Jian-Qing Ding, Sheng-Di Chen
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Brain Inflammation : CK(1101) : AC(567), Inflammation : CK(9572) : AC(3089)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Cyclooxygenase 2 Inhibitors : CK(1589) : AC(926), Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin restores innate immune Alzheimer's disease risk gene expression to ameliorate Alzheimer pathogenesis.

Pubmed Data : Neurobiol Dis. 2019 07 ;127:432-448. Epub 2019 Apr 2. PMID: 30951849
Article Published Date : Dec 31, 2018
Authors : B Teter, T Morihara, G P Lim, T Chu, M R Jones, X Zuo, R M Paul, S A Frautschy, G M Cole
Study Type : Transgenic Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Cyclooxygenase 2 Inhibitors : CK(1589) : AC(926), Immunomodulatory : CK(4048) : AC(1475), Interleukin-1 beta downregulation : CK(3041) : AC(1567), Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin suppresses ERK1/2 and p38 signaling, thus, attenuating inflammatory responses of brain microglia.

Pubmed Data : Neurosci Lett. 2015 May 6 ;594:105-10. Epub 2015 Mar 25. PMID: 25818332
Article Published Date : May 05, 2015
Authors : Xiaolei Shi, Zhenyang Zheng, Jie Li, Zijian Xiao, Weiwei Qi, Aiwu Zhang, Qi Wu, Yannan Fang
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Interleukin-1 beta downregulation : CK(3041) : AC(1567), Interleukin-6 Downregulation : CK(5029) : AC(1994), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(6736) : AC(2815)
Additional Keywords : Dose Response : CK(1712) : AC(683)

Curcumin-based nanomedicines in the treatment of inflammatory and immunomodulated diseases.

Pubmed Data : Pharmaceutics. 2023 Jan 10 ;15(1). Epub 2023 Jan 10. PMID: 36678859
Article Published Date : Jan 09, 2023
Authors : Lucas Fornari Laurindo, Gabriel Magno de Carvalho, Bárbara de Oliveira Zanuso, Maria Eduardo Figueira, Rosa Direito, Ricardo de Alvares Goulart, Daiene Santos Buglio, Sandra Maria Barbalho
Study Type : Review
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Atherosclerosis : CK(1390) : AC(487), Coronavirus Infection : CK(1230) : AC(410), Huntington Disease : CK(188) : AC(78), Inflammatory Bowel Diseases : CK(1994) : AC(540), Liver Fibrosis : CK(560) : AC(253), Multiple Sclerosis : CK(1802) : AC(394), Parkinson's Disease : CK(1838) : AC(659), Psoriasis : CK(594) : AC(144), Rheumatoid Arthritis : CK(1546) : AC(328)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Immunomodulatory : CK(4048) : AC(1475)

Neuroinflammation in pathogenesis of Alzheimer's disease: phytochemicals as potential therapeutics.

Pubmed Data : Mech Ageing Dev. 2020 May 22:111259. Epub 2020 May 22. PMID: 32450086
Article Published Date : May 21, 2020
Authors : Alexander Vaiserman, Alexander Koliada, Oleh Lushchak
Study Type : Review
Additional Links
Substances : Curcumin : CK(5598) : AC(2788), Genistein : CK(788) : AC(365), Quercetin : CK(1179) : AC(590), Resveratrol : CK(2037) : AC(1112)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Brain Inflammation : CK(1101) : AC(567)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Neuroprotective Agents : CK(10404) : AC(4396)

NPs-Cur enhance the action of curcumin on several pathways implicated in the pathophysiology of Alzheimer's disease.

Pubmed Data : Mol Pharm. 2015 Dec 23. Epub 2015 Dec 23. PMID: 26618861
Article Published Date : Dec 22, 2015
Authors : Ghislain Djiokeng Paka, Sihem Doggui, Ahlem Zaghmi, Ramia Safar, Lé Dao, Andreas Reisch, Andrey Klymchenko, V Gaëlle Roullin, Olivier Joubert, Charles Ramassamy
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Antioxidants : CK(21528) : AC(8856), Neuroprotective Agents : CK(10404) : AC(4396)

Possible role of common spices as a preventive and therapeutic agent for Alzheimer's disease.

Pubmed Data : Int J Prev Med. 2017 ;8:5. Epub 2017 Feb 7. PMID: 28250905
Article Published Date : Dec 31, 2016
Authors : Omid Mirmosayyeb, Amirpouya Tanhaei, Hamid R Sohrabi, Ralph N Martins, Mana Tanhaei, Mohammad Amin Najafi, Ali Safaei, Rokhsareh Meamar
Study Type : Review
Additional Links
Substances : Cinnamon : CK(406) : AC(150), Culinary Herbs and Spices : CK(11065) : AC(3218), Ginger : CK(1261) : AC(363), Saffron : CK(864) : AC(189), Turmeric : CK(7078) : AC(3169)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Dementia : CK(1689) : AC(279)
Pharmacological Actions : Acetylcholinesterase Inhibitor : CK(170) : AC(95), Anti-Inflammatory Agents : CK(20859) : AC(8334)

Role of Polyphenols in alleviating Alzheimer's disease: A Review

Pubmed Data : Curr Med Chem. 2022 Dec 2. Epub 2022 Dec 2. PMID: 36476438
Article Published Date : Dec 01, 2022
Authors : Tharsius Raja William Raja, Veeramuthu Duraipandiyan, Savarimuthu Ignacimuthu, Udaiyappan Janakiraman, Soosaimanickam Maria Packiam
Study Type : Review
Additional Links
Substances : Catechin : CK(718) : AC(253), Curcumin : CK(5598) : AC(2788), Hesperidin : CK(545) : AC(215), Kaempferol : CK(102) : AC(65), Polyphenols : CK(1878) : AC(700), Quercetin : CK(1179) : AC(590), Resveratrol : CK(2037) : AC(1112)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Antioxidants : CK(21528) : AC(8856), Neuroprotective Agents : CK(10404) : AC(4396)

The preventive and therapeutic potential of polyphenolic nutraceuticals in Alzheimer's disease.

Pubmed Data : Adv Protein Chem Struct Biol. 2017 ;108:33-57. Epub 2017 Mar 22. PMID: 28427563
Article Published Date : Dec 31, 2016
Authors : Yousef Sawikr, Nagendra Sastry Yarla, Ilaria Peluso, Mohammad Amjad Kamal, Gjumrakch Aliev, Anupam Bishayee
Study Type : Review
Additional Links
Substances : Curcumin : CK(5598) : AC(2788), Flavonoids : CK(2352) : AC(870), Piperine : CK(320) : AC(159), Polyphenols : CK(1878) : AC(700), Resveratrol : CK(2037) : AC(1112)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Brain Inflammation : CK(1101) : AC(567)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Antioxidants : CK(21528) : AC(8856), NF-kappaB Inhibitor : CK(3536) : AC(2098)

This review highlights the current knowledge on the potential effects of the natural compound curcumin on cognition.

Pubmed Data : Nutrients. 2021 Apr 30 ;13(5). Epub 2021 Apr 30. PMID: 33946356
Article Published Date : Apr 29, 2021
Authors : Alessandra Berry, Barbara Collacchi, Roberta Masella, Rosaria Varì, Francesca Cirulli
Study Type : Review
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Brain Inflammation : CK(1101) : AC(567), Cognitive Decline/Dysfunction : CK(3236) : AC(654)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Antioxidants : CK(21528) : AC(8856), Neuroprotective Agents : CK(10404) : AC(4396)

Turmeric contains compounds which have potent anti-amyloidogenic effects indicating their value for Alzheimer disease.

Pubmed Data : Curr Alzheimer Res. 2009 Dec;6(6):564-71. PMID: 19715544
Article Published Date : Dec 01, 2009
Authors : R Douglas Shytle, Paula C Bickford, Kavon Rezai-zadeh, L Hou, Jin Zeng, Jun Tan, Paul R Sanberg, Cyndy D Sanberg, Bill Roschek, Ryan C Fink, Randall S Alberte
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334)
Additional Keywords : Plant Extracts : CK(14140) : AC(5210)

Turmeric extract exhibits anti-Alzheimer properties.

Pubmed Data : Curr Alzheimer Res. 2011 Aug 30. Epub 2011 Aug 30. PMID: 21875408
Article Published Date : Aug 30, 2011
Authors : R Douglas Shytle, J Tan, P C Bickford, K Rezai-Zadeh, L Hou, J Zeng, P R Sanberg, C D Sanberg, R S Alberte, R C Fink, B Roschek
Study Type : Transgenic Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Brain: Microglial Activation : CK(164) : AC(98), Brain Inflammation : CK(1101) : AC(567)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin may play a protective effect in primary cultured rat prefrontal cortical neurons against iAbeta-induced cytotoxicity.

Pubmed Data : Neurosci Lett. 2010 Aug 9;480(1):21-4. PMID: 20638958
Article Published Date : Aug 09, 2010
Authors : Xiao-Yan Qin, Yong Cheng, Long-Chuan Yu
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Apoptotic : CK(6986) : AC(5304), Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin attenuated neurodegeneration in this animal model Alzheimer's disease.

Pubmed Data : J Alzheimers Dis. 2016 Apr 5. Epub 2016 Apr 5. PMID: 27060945
Article Published Date : Apr 04, 2016
Authors : Han-Chang Huang, Bo-Wen Zheng, Yu Guo, Jian Zhao, Jiang-Yan Zhao, Xiao-Wei Ma, Zhao-Feng Jiang
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Oxidative Stress : CK(9437) : AC(3550)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin may have therapeutic value in Alzheimer disease prevention.

Pubmed Data : Cancer Lett. 2009 Nov 24. Epub 2009 Nov 24. PMID: 11755008
Article Published Date : Nov 24, 2009
Authors : S A Frautschy, W Hu, P Kim, S A Miller, T Chu, M E Harris-White, G M Cole
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin strongly induced modulator effects on oxidative stress, intracellular Ca2+ levels, and the caspase-3 and -9 values in an experimental oxidative stress model.

Pubmed Data : J Recept Signal Transduct Res. 2015 Nov 25:1-7. Epub 2015 Nov 25. PMID: 26608462
Article Published Date : Nov 24, 2015
Authors : Abdülhadi Cihangir Uğuz, Ahmi Öz, Mustafa Nazıroğlu
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Oxidative Stress : CK(9437) : AC(3550), Parkinson's Disease : CK(1838) : AC(659)
Pharmacological Actions : Anti-Apoptotic : CK(2905) : AC(1672), Antioxidants : CK(21528) : AC(8856), Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin supplementation could ameliorate cognitive deficits and reverse biochemical alterations in a ICV-streptozotocin Alzheimer's rat model.

Pubmed Data : Eur J Pharmacol. 2016 Jan 5 ;770:52-60. Epub 2015 Dec 2. PMID: 26638997
Article Published Date : Jan 04, 2016
Authors : Doaa M Samy, Cherine A Ismail, Rasha A Nassra, Teshreen M Zeitoun, Azhar M Nomair
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Brain: Oxidative Stress : CK(438) : AC(244), Diabetes Mellitus: Type 2 : CK(8552) : AC(1714)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin-loaded nanocapsules reverses the depressant-like behaviour and oxidative stress induced by β-amyloid.

Pubmed Data : Neuroscience. 2019 12 15 ;423:122-130. Epub 2019 Nov 4. PMID: 31698022
Article Published Date : Jan 14, 2019
Authors : Eduarda Monteiro Fidelis, Anne Suély Pinto Savall, Edina da Luz Abreu, Felipe Carvalho, Flávia Elizabete Guerra Teixeira, Sandra Elisa Haas, Tuane Bazanella Sampaio, Simone Pinton
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Brain: Oxidative Stress : CK(438) : AC(244), Depression : CK(6233) : AC(1096)
Pharmacological Actions : Antidepressive Agents : CK(4882) : AC(874), Antioxidants : CK(21528) : AC(8856), Catalase Up-Regulation : CK(264) : AC(112), Superoxide Dismutase Up-regulation : CK(1403) : AC(551)

Curcuminoids protect against neuronal cell death in an Alzheimer disease model.

Pubmed Data : Neurosci Lett. 2001 Apr 27;303(1):57-61. PMID: 11297823
Article Published Date : Apr 27, 2001
Authors : D S Kim, S Y Park, J K Kim
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Neuroprotective Agents : CK(10404) : AC(4396)

EGCG and curcumin suppress Alzheimer disease associated beta amyloid production.

Pubmed Data : Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H715-21. Epub 2005 Mar 18. PMID: 18695518
Article Published Date : Aug 01, 2005
Authors : Yoshiari Shimmyo, Takeshi Kihara, Akinori Akaike, Tetsuhiro Niidome, Hachiro Sugimoto
Study Type : In Vitro Study
Additional Links
Substances : Catechin : CK(718) : AC(253), Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Oxidative Stress : CK(9437) : AC(3550)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Enzyme Inhibitors : CK(692) : AC(347), Neuroprotective Agents : CK(10404) : AC(4396)

Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease.

Pubmed Data : J Ethnopharmacol. 2022 Feb 14 ;290:115107. Epub 2022 Feb 14. PMID: 35176467
Article Published Date : Feb 13, 2022
Authors : Filipe Fernandes, M Fátima Barroso, Angela De Simone, Eliška Emriková, Mónica Dias-Teixeira, José Paulo Pereira, Jakub Chlebek, Virgínia Cruz Fernandes, Francisca Rodrigues, Vincenza Andrisano, Cristina Delerue-Matos, Clara Grosso
Study Type : In Vitro Study
Additional Links
Substances : Chinese Skullcap : CK(143) : AC(75), Fenugreek : CK(452) : AC(115), Ginkgo biloba : CK(1071) : AC(269), Lavender : CK(454) : AC(66), Rosemary : CK(413) : AC(163), St. Johns Wort : CK(322) : AC(101), Turmeric : CK(7078) : AC(3169)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Neuroprotective Agents : CK(10404) : AC(4396)

Protective and anti-oxidative effects of curcumin and resveratrol on Aβ-oligomer-induced damage in the SH-SY5Y cell line.

Pubmed Data : J Neurol Sci. 2022 Aug 1 ;441:120356. Epub 2022 Aug 1. PMID: 35963200
Article Published Date : Jul 31, 2022
Authors : Haibo Yu, Toru Yamashita, Xiao Hu, Zhihong Bian, Xinrang Hu, Tian Feng, Koh Tadokoro, Ryuta Morihara, Koji Abe
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788), Resveratrol : CK(2037) : AC(1112)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Neuroprotective Agents : CK(10404) : AC(4396)

Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer's disease.

Pubmed Data : Mutat Res. 2009 Feb 10;661(1-2):25-34. Epub 2008 Nov 6. PMID: 19027755
Article Published Date : Feb 10, 2009
Authors : Philip Thomas, Yan-Jiang Wang, Jin-Hua Zhong, Shantha Kosaraju, Nathan J O'Callaghan, Xin-Fu Zhou, Michael Fenech
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788), Flavonoids : CK(2352) : AC(870), Grapefruit Seed Extract : CK(51) : AC(18), Polyphenols : CK(1878) : AC(700)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Genoprotective : CK(477) : AC(177), Neuroprotective Agents : CK(10404) : AC(4396)
Additional Keywords : Plant Extracts : CK(14140) : AC(5210)

This study investigated the neuroprotective effects of turmeric extract.

Pubmed Data : Sci Rep. 2016 Dec 22 ;6:38846. Epub 2016 Dec 22. PMID: 28004737
Article Published Date : Dec 21, 2016
Authors : Rosario Randino, Manuela Grimaldi, Marco Persico, Augusta De Santis, Elena Cini, Walter Cabri, Antonella Riva, Gerardino D'Errico, Caterina Fattorusso, Anna Maria D'Ursi, Manuela Rodriquez
Study Type : In Vitro Study
Additional Links
Substances : Curcuminoids : CK(6042) : AC(2905), Turmeric : CK(7078) : AC(3169)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)
Additional Keywords : Plant Extracts : CK(14140) : AC(5210)

A combined plant extract WS-5 could be applied as a natural product therapy with a focus on neuroinflammation-related neurodegenerative disorders.

Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:5160293. Epub 2019 Apr 1. PMID: 31057649
Article Published Date : Dec 31, 2018
Authors : Ju Eun Kim, Abinash Chandra Shrestha, Hyo Shin Kim, Ha Neul Ham, Jun Hyeong Kim, Yeong Jee Kim, Yun Jeong Noh, Su Jin Kim, Dae Keun Kim, Hyung Kwon Jo, Dae Sung Kim, Kwang Hyun Moon, Jeong Ho Lee, Kyung Ok Jeong, Jae Yoon Leem
Study Type : Animal Study
Additional Links
Substances : Ginger : CK(1261) : AC(363), Turmeric : CK(7078) : AC(3169)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Neurodegenerative Diseases : CK(8689) : AC(2653)
Pharmacological Actions : Acetylcholinesterase Inhibitor : CK(170) : AC(95), Neuroprotective Agents : CK(10404) : AC(4396)

A curcumin metabolite protects against Alzheimer disease associated amyloidβ-induced toxicity.

Pubmed Data : Neuroreport. 2010 Nov 24. Epub 2010 Nov 24. PMID: 21116204
Article Published Date : Nov 24, 2010
Authors : Shilpa Mishra, Mamata Mishra, Pankaj Seth, Shiv Kumar Sharma
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

A supplement containing huperzine A and curcumin in dementia patients and individuals with mild cognitive impairment had beneficial effects.

Pubmed Data : J Alzheimers Dis. 2018 ;63(1):75-78. PMID: 29614668
Article Published Date : Dec 31, 2017
Authors : Takeshi Tabira, Nobutoshi Kawamura
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788), Huperzine : CK(183) : AC(59)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Dementia with Lewy bodies (DLB) : CK(13) : AC(2)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Alzheimer's disease, inflammation, and the role of antioxidants.

Pubmed Data : J Alzheimers Dis Rep. 2020 Jun 16 ;4(1):175-183. Epub 2020 Jun 16. PMID: 32715278
Article Published Date : Jun 15, 2020
Authors : Benjamin Sinyor, Jocelyn Mineo, Christopher Ochner
Study Type : Review
Additional Links
Substances : Caffeine : CK(411) : AC(75), Turmeric : CK(7078) : AC(3169), Vitamin E : CK(2533) : AC(483)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Brain Inflammation : CK(1101) : AC(567)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Beneficial effects of epigallocatechin-3- O-gallate, chlorogenic acid, resveratrol, and curcumin on neurodegenerative diseases.

Pubmed Data : Molecules. 2021 Jan 14 ;26(2). Epub 2021 Jan 14. PMID: 33466849
Article Published Date : Jan 13, 2021
Authors : Ryuuta Fukutomi, Tomokazu Ohishi, Yu Koyama, Monira Pervin, Yoriyuki Nakamura, Mamoru Isemura
Study Type : Review
Additional Links
Substances : Chlorogenic Acid : CK(299) : AC(113), Curcumin : CK(5598) : AC(2788), EGCG (Epigallocatechin gallate) : CK(1091) : AC(605), Resveratrol : CK(2037) : AC(1112)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Neurodegenerative Diseases : CK(8689) : AC(2653), Parkinson's Disease : CK(1838) : AC(659)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Coronarin D, a metabolite from the wild turmeric, Curcuma aromatica, promotes the differentiation of neural stem cells into astrocytes.

Pubmed Data : J Agric Food Chem. 2022 Mar 16 ;70(10):3300-3309. Epub 2022 Mar 4. PMID: 35245031
Article Published Date : Mar 15, 2022
Authors : Satoshi Otsuka, Midori Kawamura, Shutaro Fujino, Fumiaki Nakamura, Daisuke Arai, Nobuhiro Fusetani, Yoichi Nakao
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin ameliorates cognitive deficits and neurodegeneration in a rat model of sporadic dementia of Alzheimer's type (SDAT).

Pubmed Data : Eur Neuropsychopharmacol. 2009 Sep;19(9):636-47. Epub 2009 Mar 28. PMID: 19329286
Article Published Date : Sep 01, 2009
Authors : Tauheed Ishrat, Md Nasrul Hoda, M Badruzzaman Khan, Seema Yousuf, Muzamil Ahmad, Mohd Moshahid Khan, Ajmal Ahmad, Fakhrul Islam
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin and piperine demonstrated promising neuroprotective effects.

Pubmed Data : Front Aging Neurosci. 2019 ;11:206. Epub 2019 Aug 27. PMID: 31507403
Article Published Date : Dec 31, 2018
Authors : Aimi Syamima Abdul Manap, Amelia Cheng Wei Tan, Weng Hhin Leong, Adeline Yoke Yin Chia, Shantini Vijayabalan, Aditya Arya, Eng Hwa Wong, Farzana Rizwan, Umesh Bindal, Shajan Koshy, Priya Madhavan
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788), Piperine : CK(320) : AC(159)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Acetylcholinesterase Inhibitor : CK(170) : AC(95), Neuroprotective Agents : CK(10404) : AC(4396)
Additional Keywords : Natural Substance Synergy : CK(1094) : AC(506)

Curcumin attenuates amyloid-β aggregate toxicity and modulates amyloid-β aggregation pathway.

Pubmed Data : ACS Chem Neurosci. 2015 Nov 17. Epub 2015 Nov 17. PMID: 26529184
Article Published Date : Nov 16, 2015
Authors : Arjun Thapa, Stephen D Jett, Eva Y Chi
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin binding to Aβ shifts the equilibrium in the aggregation pathway by promoting the formation of non-toxic aggregates.

Pubmed Data : Chem Biol Drug Des. 2015 Mar 16. Epub 2015 Mar 16. PMID: 25776887
Article Published Date : Mar 15, 2015
Authors : Praveen P N Rao, Tarek Mohamed, Karan Teckwani, Gary Tin
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein.

Pubmed Data : Gastroenterology. 2006 Jan;130(1):120-6. PMID: 20622013
Article Published Date : Jan 01, 2006
Authors : Can Zhang, Andrew Browne, Daniel Child, Rudolph E Tanzi
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin demonstrates therapeutic properties in an animal model of Alzheimer disease.

Pubmed Data : J Pharmacol Exp Ther. 2008 Jul;326(1):196-208. Epub 2008 Apr 16. PMID: 18417733
Article Published Date : Jul 01, 2008
Authors : Aynun N Begum, Mychica R Jones, Giselle P Lim, Takashi Morihara, Peter Kim, Dennis D Heath, Cheryl L Rock, Mila A Pruitt, Fusheng Yang, Beverly Hudspeth, Shuxin Hu, Kym F Faull, Bruce Teter, Greg M Cole, Sally A Frautschy
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Inflammation : CK(9572) : AC(3089)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin downregulates GSK3 and Cdk5 in scopolamine-induced Alzheimer's disease.

Pubmed Data : J Alzheimers Dis Rep. 2019 Aug 30 ;3(1):257-267. Epub 2019 Aug 30. PMID: 31754658
Article Published Date : Aug 29, 2019
Authors : Tushar Kanti Das, Piyali Jana, Swarup Kumar Chakrabarti, Mas R W Abdul Hamid
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin exhibits inhibitory effects on Alzheimer disease associated β-amyloid proteins.

Pubmed Data : Int Dent J. 1996 Feb;46(1):22-34. PMID: 20727383
Article Published Date : Feb 01, 1996
Authors : Hongying Liu, Zhong Li, Donghai Qiu, Qiong Gu, Qingfeng Lei, Li Mao
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin improves learning and memory ability in a mouse Alzheimer's disease experimental model.

Pubmed Data : Chin Med J (Engl). 2008 May 5;121(9):832-9. PMID: 18701050
Article Published Date : May 05, 2008
Authors : Rui Pan, Sheng Qiu, Da-xiang Lu, Jun Dong
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Memory Disorders : CK(1067) : AC(339), Memory Loss : CK(171) : AC(45)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin improves the tau-induced neuronal dysfunction that is independent of insoluble aggregates of tau.

Pubmed Data : Neurobiol Aging. 2016 Mar ;39:69-81. Epub 2015 Dec 1. PMID: 26923403
Article Published Date : Feb 29, 2016
Authors : Tomohiro Miyasaka, Ce Xie, Satomi Yoshimura, Yuki Shinzaki, Sawako Yoshina, Eriko Kage-Nakadai, Shohei Mitani, Yasuo Ihara
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Neurodegenerative Diseases : CK(8689) : AC(2653)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin inhibits amyloid-petpide induced changes associated with the progression of Alzheimer's disease.

Pubmed Data : J Neurochem. 2004 Dec;91(5):1199-210. PMID: 15569263
Article Published Date : Dec 01, 2004
Authors : Ranjit K Giri, Vikram Rajagopal, Vijay K Kalra
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Enzyme Inhibitors : CK(692) : AC(347), Epidermal growth factor receptor (EGFR) inhibitor : CK(87) : AC(60), Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin inhibits Aβ-induced neuronal damage and cell death involving the prevention from intracellular Ca2+ elevation mediated by the NMDA receptor.

Pubmed Data : J Recept Signal Transduct Res. 2015 Jun 8:1-8. Epub 2015 Jun 8. PMID: 26053510
Article Published Date : Jun 07, 2015
Authors : Han-Chang Huang, Ping Chang, Shu-Yan Lu, Bo-Wen Zheng, Zhao-Feng Jiang
Study Type : Human In Vitro
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Neurodegenerative Diseases : CK(8689) : AC(2653)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)
Additional Keywords : Dose Response : CK(1712) : AC(683)

Curcumin inhibits the conversion of prion protein in vitro.

Pubmed Data : J Neurochem. 2008 Mar ;104(6):1553-64. Epub 2007 Nov 7. PMID: 17996023
Article Published Date : Feb 29, 2008
Authors : Iva Hafner-Bratkovic, Jernej Gaspersic, Lojze M Smid, Mara Bresjanac, Roman Jerala
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Creutzfeldt-Jakob disease : CK(34) : AC(16), Prion Diseases : CK(10) : AC(7)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin may be a potential therapeutic agent that can regulate the critical molecules in brain insulin signalling pathways.

Pubmed Data : Int J Immunopathol Pharmacol. 2016 Jul 27. Epub 2016 Jul 27. PMID: 27466310
Article Published Date : Jul 26, 2016
Authors : Hui-Li Feng, Hui-Zi Dang, Hui Fan, Xiao-Pei Chen, Ying-Xue Rao, Ying Ren, Jin-Duo Yang, Jing Shi, Peng-Wen Wang, Jin-Zhou Tian
Study Type : Transgenic Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin may have therapeutic value in Alzheimer disease.

Pubmed Data : Brain Res. 2010 Nov 18;1361:115-23. Epub 2010 Sep 16. PMID: 20840842
Article Published Date : Nov 18, 2010
Authors : Zijian Xiao, Liming Lin, Zhonghua Liu, Fengtao Ji, Weiyan Shao, Minjuan Wang, Ling Liu, Shengliang Li, Feng Li, Xianzhang Bu
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin protects against beta-amyloid-induced toxicity.

Pubmed Data : Food Chem Toxicol. 2008 Aug;46(8):2881-7. Epub 2008 Jun 4. PMID: 18573304
Article Published Date : Aug 01, 2008
Authors : So-Young Park, Hyo-Shin Kim, Eun-Kyung Cho, Bo-Youn Kwon, Sohee Phark, Kwang-Woo Hwang, Donggeun Sul
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), DNA damage : CK(1997) : AC(713), Oxidative Stress : CK(9437) : AC(3550)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin treatment improves motor behavior in α-synuclein transgenic mice.

Pubmed Data : PLoS One. 2015 ;10(6):e0128510. Epub 2015 Jun 2. PMID: 26035833
Article Published Date : Dec 31, 2014
Authors : Kateri J Spinelli, Valerie R Osterberg, Charles K Meshul, Amala Soumyanath, Vivek K Unni
Study Type : Transgenic Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Parkinson's Disease : CK(1838) : AC(659)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease.

Pubmed Data : Neuroscience. 2010 Sep 1;169(3):1296-306. Epub 2010 Jun 9. PMID: 20538041
Article Published Date : Sep 01, 2010
Authors : T Ahmed, S A Enam, A H Gilani
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Memory Disorders : CK(1067) : AC(339)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Curcuminoids rescue long-term potentiation impaired by amyloid peptide in rat hippocampal slices.

Pubmed Data : Synapse. 2010 Oct 20. Epub 2010 Oct 20. PMID: 20963814
Article Published Date : Oct 20, 2010
Authors : Touqeer Ahmed, Anwarul-Hassan Gilani, Narges Hosseinmardi, Saeed Semnanian, Syed Ather Enam, Yaghoub Fathollahi
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Brain Injury: Hippocampal Damage : CK(40) : AC(19)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Differential neuroprotective effect of curcuminoid formulations in aluminum chloride-induced Alzheimer's disease.

Pubmed Data : Environ Sci Pollut Res Int. 2022 May 7. Epub 2022 May 7. PMID: 35525893
Article Published Date : May 06, 2022
Authors : Anam Shabbir, Kanwal Rehman, Muhammad Sajid Hamid Akash, Moazzama Akbar, Zunera Chaudhary, Pharkphoom Panichayupakaranant, Muhammad Ajmal Shah
Study Type : Animal Study
Additional Links
Substances : Turmeric : CK(7078) : AC(3169)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)
Problem Substances : Aluminum Chloride : CK(114) : AC(55)

Discovery of natural products from Curcuma longa that protect cells from beta-amyloid insult.

Pubmed Data : J Nat Prod. 2002 Sep ;65(9):1227-31. PMID: 12350137
Article Published Date : Aug 31, 2002
Authors : So-Young Park, Darrick S H L Kim
Study Type : In Vitro Study
Additional Links
Substances : Turmeric : CK(7078) : AC(3169)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Effects of curcumin and ferulic acid on the folding of amyloid-β peptide.

Pubmed Data : Molecules. 2021 May 10 ;26(9). Epub 2021 May 10. PMID: 34068636
Article Published Date : May 09, 2021
Authors : Evdokiya Salamanova, Mariyana Atanasova, Ivan Dimitrov, Irini Doytchinova
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788), Ferulic acid : CK(33) : AC(21)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Flavonoids and its neuroprotective effects on brain ischemia and neurodegenerative diseases.

Pubmed Data : Curr Drug Targets. 2018 Mar 26. Epub 2018 Mar 26. PMID: 29577854
Article Published Date : Mar 25, 2018
Authors : Manish Putteeraj, Wei Ling Lim, Seong Lin Teoh, Mohamad Fairuz Yahaya
Study Type : Review
Additional Links
Substances : Curcumin : CK(5598) : AC(2788), Flavonoids : CK(2352) : AC(870), Ginsenosides : CK(1550) : AC(873), Lycopene : CK(886) : AC(249)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Brain Ischemia : CK(341) : AC(151), Parkinson's Disease : CK(1838) : AC(659)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Formulation and development of curcumin-piperine-loaded S-SNEDDS for the treatment of alzheimer's disease.

Pubmed Data : Mol Neurobiol. 2023 Feb ;60(2):1067-1082. Epub 2022 Nov 21. PMID: 36414909
Article Published Date : Jan 31, 2023
Authors : Shmmon Ahmad, Abdul Hafeez
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788), Piperine : CK(320) : AC(159)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Insights into the effect of curcumin and (-)-epigallocatechin-3-gallate on the aggregation of Aβ(1-40) monomers by means of molecular dynamics.

Pubmed Data : Int J Mol Sci. 2020 Jul 30 ;21(15). Epub 2020 Jul 30. PMID: 32751722
Article Published Date : Jul 29, 2020
Authors : Francesco Tavanti, Alfonso Pedone, Maria Cristina Menziani
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788), EGCG (Epigallocatechin gallate) : CK(1091) : AC(605)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Investigating a curcumin-loaded PLGA-PEG-PLGA thermo-sensitive hydrogel for the prevention of Alzheimer's disease.

Pubmed Data : Antioxidants (Basel). 2022 Apr 7 ;11(4). Epub 2022 Apr 7. PMID: 35453412
Article Published Date : Apr 06, 2022
Authors : Yi-Wen Lin, Chih-Hsiang Fang, Ching-Yun Yang, Ya-Jyun Liang, Feng-Huei Lin
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Long-term consumption of aromatic compounds from spices could be effective in the prevention of Alzheimer's disease.

Pubmed Data : Nat Prod Commun. 2016 Apr ;11(4):507-10. PMID: 27396206
Article Published Date : Mar 31, 2016
Authors : Shinichi Matsumura, Kazuya Murata, Yuri Yoshioka, Hideaki Matsuda
Study Type : In Vitro Study
Additional Links
Substances : Cardamom : CK(42) : AC(11), Cinnamon : CK(406) : AC(150), Ginger : CK(1261) : AC(363), Long Pepper : CK(29) : AC(12), Turmeric : CK(7078) : AC(3169)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396), β-secretase Inhibitor : CK(1) : AC(1)

Natural anti-inflammatory compounds as treatment candidates in Alzheimer’s disease.

Pubmed Data : Curr Med Chem. 2020 Jul 30. Epub 2020 Jul 30. PMID: 32744957
Article Published Date : Jul 29, 2020
Authors : Reyaz Hassan Mir, Abdul Jalil Shah, Roohi Mohi-Ud-Din, Faheem Hyder Potoo, Mohd Akbar Dar, Sanjay M Jachak, Mubashir Hussain Masoodi
Study Type : Review
Additional Links
Substances : Berberine : CK(1280) : AC(627), Curcumin : CK(5598) : AC(2788), Genistein : CK(788) : AC(365), Quercetin : CK(1179) : AC(590), Resveratrol : CK(2037) : AC(1112), Rosmarinic acid : CK(47) : AC(26)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Neuroprotective effects of curcumin through autophagy modulation.

Pubmed Data : IUBMB Life. 2019 Dec 5. Epub 2019 Dec 5. PMID: 31804772
Article Published Date : Dec 04, 2019
Authors : Fatemeh Forouzanfar, Morgayn I Read, George E Barreto, Amirhossein Sahebkar
Study Type : Review
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alexander Disease : CK(1) : AC(1), Alzheimer's Disease : CK(3372) : AC(1307), Parkinson's Disease : CK(1838) : AC(659), Stroke: Ischemic : CK(557) : AC(118), Traumatic Brain Injury : CK(88) : AC(25)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

New promising therapeutic avenues of curcumin in brain diseases.

Pubmed Data : Molecules. 2021 Dec 31 ;27(1). Epub 2021 Dec 31. PMID: 35011468
Article Published Date : Dec 30, 2021
Authors : Tarek Benameur, Giulia Giacomucci, Maria Antonietta Panaro, Melania Ruggiero, Teresa Trotta, Vincenzo Monda, Ilaria Pizzolorusso, Dario Domenico Lofrumento, Chiara Porro, Giovanni Messina
Study Type : Review
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Brain Diseases : CK(19) : AC(8), Parkinson's Disease : CK(1838) : AC(659)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Phosphatidylserine and curcumin can ameliorate scopolamine-induced amnesia and may be useful treatments for Alzheimer's disease.

Pubmed Data : Behav Pharmacol. 2016 Jul 6. Epub 2016 Jul 6. PMID: 27388114
Article Published Date : Jul 05, 2016
Authors : Teresa A Barber, Edward M Edris, Paul J Levinsky, Justin M Williams, Ari R Brouwer, Shawn A Gessay
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788), Phosphatidylserine : CK(134) : AC(20)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Amnesia: Drug-Induced : CK(36) : AC(20)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Review: Curcumin has a number of potential therapeutic properties for Alzheimer diseaes.

Pubmed Data : Mutat Res. 2009 Oct 13. Epub 2009 Oct 13. PMID: 19966973
Article Published Date : Oct 13, 2009
Authors : Shrikant Mishra, Kalpana Palanivelu
Study Type : Review
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Role of curcumin and its nanoformulations in neurotherapeutics: A comprehensive review.

Pubmed Data : J Biochem Mol Toxicol. 2020 Mar 2:e22478. Epub 2020 Mar 2. PMID: 32124518
Article Published Date : Mar 01, 2020
Authors : Mukesh Mandal, Pawan Jaiswal, Awanish Mishra
Study Type : Review
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Parkinson's Disease : CK(1838) : AC(659)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Supplementation with Curcuma longa reverses neurotoxic and behavioral damage in models of Alzheimer's disease.

Pubmed Data : Curr Neuropharmacol. 2018 Jan 16. Epub 2018 Jan 16. PMID: 29338678
Article Published Date : Jan 15, 2018
Authors : Ianara Mendonca da Costa, Marco Aurelio de Moura Freire, Jose Rodolfo Lopes de Paiva Cavalcanti, Dayane Pessoa de Araujo, Bianca Norrara, Isleania Maria Marques Moreira Rosa, Eduardo Pereira de Azevedo, Amalia Cinthia Meneses do Rego, Irami Araujo Filho, Fausto Pierdona Guzen
Study Type : Review
Additional Links
Substances : Turmeric : CK(7078) : AC(3169)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)
Additional Keywords : Neuroprotective Agents : CK(10404) : AC(4396), Neuroprotective Agents : CK(10404) : AC(4396), Neuroprotective Agents : CK(10404) : AC(4396)

Synergic effects of berberine and curcumin on improving cognitive function in an Alzheimer's disease mouse model.

Pubmed Data : Neurochem Res. 2020 Feb 21. Epub 2020 Feb 21. PMID: 32080784
Article Published Date : Feb 20, 2020
Authors : Lin Lin, Cheng Li, Deyi Zhang, Mingxiang Yuan, Chun-Hai Chen, Maoquan Li
Study Type : Animal Study
Additional Links
Substances : Berberine : CK(1280) : AC(627), Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)
Additional Keywords : Natural Substance Synergy : CK(1094) : AC(506)

Tetrahydrocurcumin has similar anti-amyloid properties as curcumin.

Pubmed Data : Antioxidants (Basel). 2021 Oct 11 ;10(10). Epub 2021 Oct 11. PMID: 34679727
Article Published Date : Oct 10, 2021
Authors : Panchanan Maiti, Jayeeta Manna, Joshua Thammathong, Bobbi Evans, Kshatresh Dutta Dubey, Souvik Banerjee, Gary L Dunbar
Study Type : In Vitro Study
Additional Links
Substances : Tetrahydrocurcumin : CK(123) : AC(68)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

The immunopathogenesis of Alzheimer's disease is related to the composition of gut microbiota.

Pubmed Data : Nutrients. 2021 Jan 25 ;13(2). Epub 2021 Jan 25. PMID: 33504065
Article Published Date : Jan 24, 2021
Authors : Friedrich Leblhuber, Daniela Ehrlich, Kostja Steiner, Simon Geisler, Dietmar Fuchs, Lukas Lanser, Katharina Kurz
Study Type : Review
Additional Links
Substances : Curcumin : CK(5598) : AC(2788), Probiotics : CK(7680) : AC(1196)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Dysbiosis : CK(1527) : AC(422)
Therapeutic Actions : Dietary Modification: Mediterranean Diet : CK(1580) : AC(186)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)
Additional Keywords : Gut-brain Axis : CK(392) : AC(177)

This review examines the efficacy of curcumin to treat Alzheimer's disease.

Pubmed Data : J Alzheimers Dis. 2017 May 17. Epub 2017 May 17. PMID: 28527218
Article Published Date : May 16, 2017
Authors : Mengxi Tang, Changiz Taghibiglou
Study Type : Review
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Acetylcholinesterase Inhibitor : CK(170) : AC(95), Anticholesteremic Agents : CK(3078) : AC(530), Neuroprotective Agents : CK(10404) : AC(4396)

This review summarizes recent findings on the protective roles of redox nanoparticles both in vitro and in vivo.

Pubmed Data : Curr Drug Metab. 2016 ;17(2):142-9. PMID: 26806041
Article Published Date : Dec 31, 2015
Authors : Magisetty Obulesu, Magisetty Jhansilakshmi
Study Type : Review
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Curcumin (from Turmeric) reduces amyloid beta plaque formation in an animal model of Alzheimers disease.

Pubmed Data : Neurochem Int. 2009 Mar-Apr;54(3-4):199-204. Epub 2008 Nov 30. PMID: 15590663
Article Published Date : Mar 01, 2009
Authors : Fusheng Yang, Giselle P Lim, Aynun N Begum, Oliver J Ubeda, Mychica R Simmons, Surendra S Ambegaokar, Pingping P Chen, Rakez Kayed, Charles G Glabe, Sally A Frautschy, Gregory M Cole
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)

Curcumin (from Turmeric) reduces oxidative damage and amyloid plaque in a transgenic animal model of Alzheimers.

Pubmed Data : J Neurosci. 2001 Nov 1;21(21):8370-7. PMID: 11606625
Article Published Date : Nov 01, 2001
Authors : G P Lim, T Chu, F Yang, W Beech, S A Frautschy, G M Cole
Study Type : Transgenic Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)

Curcumin administration suppress acetylcholinesterase gene expression in cadmium treated rats.

Pubmed Data : Neurotoxicology. 2017 May 17. Epub 2017 May 17. PMID: 28527659
Article Published Date : May 16, 2017
Authors : Ayodele Jacob Akinyemi, Ganiyu Oboh, Adewale Oluwaseun Fadaka, Babawale Peter Olatunji, Seun Akomolafe
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Cadmium Poisoning : CK(306) : AC(152)
Pharmacological Actions : Acetylcholinesterase Inhibitor : CK(170) : AC(95)
Problem Substances : Cadmium : CK(383) : AC(148)

Curcumin and rosemary have anti-Alzheimer's activity.

Pubmed Data : J Neurosci Res. 2004 Mar 15;75(6):742-50. PMID: 14994335
Article Published Date : Mar 15, 2004
Authors : Kenjiro Ono, Kazuhiro Hasegawa, Hironobu Naiki, Masahito Yamada
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788), Rosemary : CK(413) : AC(163)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Platelet Aggregation Inhibitors : CK(200) : AC(45)

Curcumin appears to enhance clearance of amyloid-beta in Alzheimer's disease patients.

Pubmed Data : J Alzheimers Dis. 2006 Sep;10(1):1-7. PMID: 16988474
Article Published Date : Sep 01, 2006
Authors : Laura Zhang, Milan Fiala, John Cashman, James Sayre, Araceli Espinosa, Michelle Mahanian, Justin Zaghi, Vladimir Badmaev, Michael C Graves, George Bernard, Mark Rosenthal
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Additional Keywords : Disease Regression : CK(151) : AC(27)

Curcumin inhibits appoptosin induced apoptosis in SH-SY5Y cells by upregulating the expression of HO-1.

Pubmed Data : Acta Pharmacol Sin. 2015 May ;36(5):544-52. Epub 2015 Apr 20. PMID: 25891083
Article Published Date : Apr 30, 2015
Authors : Kun-mu Zheng, Jing Zhang, Cui-lin Zhang, Yun-wu Zhang, Xiao-chun Chen
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Pharmacological Actions : Anti-Apoptotic : CK(2905) : AC(1672), Heme oxygenase-1 up-regulation : CK(624) : AC(373)

Curcumin reverses amyloid pathology and associated neurotoxicity in a mouse model of Alzheimer disease.

Pubmed Data : J Neurochem. 2007 Aug;102(4):1095-104. Epub 2007 Apr 30. PMID: 17472706
Article Published Date : Aug 01, 2007
Authors : M Garcia-Alloza, L A Borrelli, A Rozkalne, B T Hyman, B J Bacskai
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Additional Keywords : Disease Reversal : CK(67) : AC(18)

Curcumin's higher binding affinity for iron and copper rather than zinc may contribute to its protective effect in Alzheimer's disease.

Pubmed Data : J Alzheimers Dis. 2004 Aug;6(4):367-77; discussion 443-9. PMID: 15345806
Article Published Date : Aug 01, 2004
Authors : Larry Baum, Alex Ng
Study Type : Review
Additional Links
Substances : Curcumin : CK(5598) : AC(2788), Zinc : CK(1486) : AC(267)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)

Discovery of natural compounds as nonpeptidyl inhibitors is a significant transition towards feasible drug development for neurodegenerative disorders.

Pubmed Data : Biomed Res Int. 2015 ;2015:379817. Epub 2015 May 4. PMID: 26064904
Article Published Date : Dec 31, 2014
Authors : Saif Khan, Khurshid Ahmad, Eyad M A Alshammari, Mohd Adnan, Mohd Hassan Baig, Mohtashim Lohani, Pallavi Somvanshi, Shafiul Haque
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788), Rosmarinic acid : CK(47) : AC(26)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Amyotrophic lateral sclerosis (ALS) : CK(748) : AC(191), Huntington Disease : CK(188) : AC(78), Neurodegenerative Diseases : CK(8689) : AC(2653), Parkinson's Disease : CK(1838) : AC(659)
Pharmacological Actions : Nonpeptidyl Inhibitors : CK(1) : AC(1)

Polyphenols such as curcumin and EGCG from green tea may chelate out iron from the Alzheimers brain.

Pubmed Data : Prog Neurobiol. 2007 Aug;82(6):348-60. Epub 2007 Jun 19. PMID: 17659826
Article Published Date : Aug 01, 2007
Authors : Silvia Mandel, Tamar Amit, Orit Bar-Am, Moussa B H Youdim
Study Type : Commentary
Additional Links
Substances : Curcumin : CK(5598) : AC(2788), EGCG (Epigallocatechin gallate) : CK(1091) : AC(605), Green Tea : CK(3450) : AC(1057), Polyphenols : CK(1878) : AC(700)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307), Iron Overload : CK(120) : AC(46)

Vitamin D3 and curcuminoids (turmeric) stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patients.

Pubmed Data : J Alzheimers Dis. 2009 Jul;17(3):703-17. PMID: 19433889
Article Published Date : Jul 01, 2009
Authors : Ava Masoumi, Ben Goldenson, Senait Ghirmai, Hripsime Avagyan, Justin Zaghi, Ken Abel, Xueying Zheng, Araceli Espinosa-Jeffrey, Michelle Mahanian, Phillip T Liu, Martin Hewison, Matthew Mizwickie, John Cashman, Milan Fiala
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(5598) : AC(2788), Vitamin D : CK(8897) : AC(1260)
Diseases : Alzheimer's Disease : CK(3372) : AC(1307)
Additional Keywords : Disease Regression : CK(151) : AC(27)

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