Focused Research Topics Turmeric & Anti-Inflammatory Agents

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Associated Topics included in this Focused Research

Curcumin Curcumin: Lipidated Curcuminoids Curcumol Demethoxycurcumin Tetrahydrocurcumin Turmeric Turmeric: Fermented Turmeric: Topical Turmerin Turmerones

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255 Research Articles in Total

A review on curcumins wound healing properties provides evidence for enhanced granulation tissue formation, collagen deposition, tissue remodeling and wound contraction.

Pubmed Data : Life Sci. 2014 Oct 22 ;116(1):1-7. Epub 2014 Sep 6. PMID: 25200875
Article Published Date : Oct 21, 2014
Authors : Dania Akbik, Maliheh Ghadiri, Wojciech Chrzanowski, Ramin Rohanizadeh
Study Type : Review
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Inflammation : CK(3240) : AC(882), Oxidative Stress : CK(3871) : AC(1382), Wound Healing : CK(539) : AC(161)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682)

Antioxidants ameliorated Tetrachlorobenzoquinone induced ROS generation as well as the activation of NF-κB.

Pubmed Data : Environ Toxicol Pharmacol. 2015 Dec 21 ;41:241-250. Epub 2015 Dec 21. PMID: 26745386
Article Published Date : Dec 20, 2015
Authors : Juanli Fu, Qiong Shi, Xiufang Song, Xiaomin Xia, Chuanyang Su, Zixuan Liu, Erqun Song, Yang Song
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), NAC (N-acetyl-L-cysteine) : CK(295) : AC(72), Vitamin E : CK(1656) : AC(290)
Diseases : Inflammation : CK(3240) : AC(882), Oxidative Stress : CK(3871) : AC(1382)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682), NF-kappaB Inhibitor : CK(1114) : AC(694)
Problem Substances : Persistent organic pollutants (POPs) : CK(114) : AC(15)

C. longa is a safe and potent anti-inflammatory and antioxidant substance beneficial in the fight against IBD.

Pubmed Data : BMC Complement Altern Med. 2016 ;16(1):72. Epub 2016 Feb 23. PMID: 26907175
Article Published Date : Dec 31, 2015
Authors : Salim M A Bastaki, Mohammed Majed Al Ahmed, Ahmed Al Zaabi, Naheed Amir, Ernest Adeghate
Study Type : Animal Study
Additional Links
Substances : Turmeric : CK(5032) : AC(2348)
Diseases : Inflammatory Bowel Diseases : CK(1052) : AC(197), Oxidative Stress : CK(3871) : AC(1382)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682)

Cisplatin-induced LLC-PK1 renal cell damage was significantly reduced by tetrahydrocurcumin treatment.

Pubmed Data : Planta Med. 2015 Mar ;81(4):286-91. Epub 2015 Feb 26. PMID: 25719941
Article Published Date : Feb 28, 2015
Authors : Kyung Il Song, Jun Yeon Park, Seungyong Lee, Dahae Lee, Hyuk-Jai Jang, Su-Nam Kim, Hyeonseok Ko, Hyun Young Kim, Jae Wook Lee, Gwi Seo Hwang, Ki Sung Kang, Noriko Yamabe
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Tetrahydrocurcumin : CK(66) : AC(30)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(319) : AC(133), Oxidative Stress : CK(3871) : AC(1382)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682), Chemoprotective Agents : CK(356) : AC(146), Chemotherapeutic : CK(397) : AC(152), Renoprotective : CK(572) : AC(254)

Curcumin could protect against the vascular side effects of methotrexate by preventing an increase in oxidative stress.

Pubmed Data : Can J Physiol Pharmacol. 2015 Nov 16:1-8. Epub 2015 Nov 16. PMID: 26571019
Article Published Date : Nov 15, 2015
Authors : Himanshu Sankrityayan, Anuradha S Majumdar
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Folic Acid : CK(645) : AC(94)
Diseases : Drug Toxicity: Methotrexate : CK(39) : AC(18), Endothelial Dysfunction : CK(1210) : AC(237), Oxidative Stress : CK(3871) : AC(1382)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682)

Curcumin oil has a protective effect against cisplatin-induced nephrotoxicity.

Pubmed Data : J Agric Food Chem. 2007 Dec 12;55(25):10150-5. Epub 2007 Nov 15. PMID: 18001039
Article Published Date : Dec 12, 2007
Authors : Anurag Kuhad, Sangeeta Pilkhwal, Sameer Sharma, Naveen Tirkey, Kanwaljit Chopra
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(319) : AC(133), Inflammation : CK(3240) : AC(882), Oxidative Stress : CK(3871) : AC(1382)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682), Renoprotective : CK(572) : AC(254), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin reduces production of ROS and inflammatory mediators in HIV-1-gp120-stimulated microglia, and protects cortical neurons against HIV-1-mediated apoptosis.

Pubmed Data : PLoS One. 2013 ;8(8):e70565. Epub 2013 Aug 6. PMID: 23936448
Article Published Date : Dec 31, 2012
Authors : Luyan Guo, Yanyan Xing, Rui Pan, Mingliang Jiang, Zheng Gong, Liqing Lin, Junbing Wang, Guoyin Xiong, Jun Dong
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : HIV Infections : CK(680) : AC(219), Inflammation : CK(3240) : AC(882), Oxidative Stress : CK(3871) : AC(1382)
Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin significantly inhibited the formation of advanced glycation end products (AGEs).

Pubmed Data : Mol Med Rep. 2015 Dec 28. Epub 2015 Dec 28. PMID: 26718010
Article Published Date : Dec 27, 2015
Authors : Yan Ping Sun, Jun Fei Gu, Xiao Bin Tan, Chun Fei Wang, Xiao Bin Jia, Liang Feng, Ji Ping Liu
Study Type : Human In Vitro
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Advanced Glycation End products (AGE) : CK(231) : AC(73), Endothelial Dysfunction : CK(1210) : AC(237), Inflammation : CK(3240) : AC(882), Oxidative Stress : CK(3871) : AC(1382)
Pharmacological Actions : Anti-Glycation Agents : CK(46) : AC(19), Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682)

Curcumin supplementation improved HFD-induced dyslipidemia, oxidative stress, inflammation and insulin resistance.

Pubmed Data : J Complement Integr Med. 2016 Feb 4. Epub 2016 Feb 4. PMID: 26845728
Article Published Date : Feb 03, 2016
Authors : Nachimuthu Maithilikarpagaselvi, Magadi Gopalakrishna Sridhar, Rathinam Palamalai Swaminathan, Ramalingam Sripradha
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Dyslipidemias : CK(391) : AC(75), High Fat Diet : CK(212) : AC(103), Inflammation : CK(3240) : AC(882), Insulin Resistance : CK(1683) : AC(346), Oxidative Stress : CK(3871) : AC(1382)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Malondialdehyde Down-regulation : CK(554) : AC(152), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin treatment ameliorates colonic damage in chemically-induced colitic rats.

Pubmed Data : World J Gastroenterol. 2007 Feb 21;13(7):1103-7. PMID: 17373747
Article Published Date : Feb 21, 2007
Authors : M V Venkataranganna, Md Rafiq, S Gopumadhavan, Ghouse Peer, U V Babu, S K Mitra
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Oxidative Stress : CK(3871) : AC(1382), Ulcerative Colitis : CK(295) : AC(59)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), NF-kappaB Inhibitor : CK(1114) : AC(694)

Short term supplementation with curcuminoid and piperine combination significantly improves oxidative and inflammatory status in patients with MetS.

Pubmed Data : Clin Nutr. 2015 Jan 7. Epub 2015 Jan 7. PMID: 25618800
Article Published Date : Jan 06, 2015
Authors : Yunes Panahi, Mahboobeh Sadat Hosseini, Nahid Khalili, Effat Naimi, Muhammed Majeed, Amirhossein Sahebkar
Study Type : Human Study
Additional Links
Substances : Curcuminoids : CK(4224) : AC(2161), Piperine : CK(114) : AC(60)
Diseases : Metabolic Diseases : CK(411) : AC(75), Oxidative Stress : CK(3871) : AC(1382)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682)
Additional Keywords : Significant Treatment Outcome : CK(3038) : AC(366)

The information presented in this paper identifies curcumin as a promising renoprotective molecule against renal injury.

Pubmed Data : Redox Biol. 2013 ;1:448-56. Epub 2013 Sep 17. PMID: 24191240
Article Published Date : Dec 31, 2012
Authors : Joyce Trujillo, Yolanda Irasema Chirino, Eduardo Molina-Jijón, Ana Cristina Andérica-Romero, Edilia Tapia, José Pedraza-Chaverrí
Study Type : Review
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Liver Damage : CK(877) : AC(329), Liver Damage: Drug-Induced : CK(95) : AC(27), Liver Disease : CK(145) : AC(41), Oxidative Stress : CK(3871) : AC(1382)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682), Chemoprotective Agents : CK(356) : AC(146), Renoprotective : CK(572) : AC(254)

Turmeric extract can successfully attenuate methotrexate hepatotoxicity.

Pubmed Data : BMC Complement Altern Med. 2015;15(1):246. Epub 2015 Jul 22. PMID: 26199067
Article Published Date : Dec 31, 2014
Authors : Adel Rezaei Moghadam, Soheil Tutunchi, Ali Namvaran-Abbas-Abad, Mina Yazdi, Fatemeh Bonyadi, Daryoush Mohajeri, Mohammad Mazani, Hassan Marzban, Marek J Łos, Saeid Ghavami
Study Type : Animal Study
Additional Links
Substances : Turmeric : CK(5032) : AC(2348)
Diseases : Drug-Induced Toxicity: Methotrexate : CK(35) : AC(10), Oxidative Stress : CK(3871) : AC(1382)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Hepatoprotective : CK(1387) : AC(594)

Turmeric supplementation could be an adjuvant to T2DM on metformin treatment having a beneficial effect on blood glucose, oxidative stress and inflammation.

Pubmed Data : Indian J Clin Biochem. 2015 Apr ;30(2):180-6. Epub 2014 May 8. PMID: 25883426
Article Published Date : Mar 31, 2015
Authors : N Maithili Karpaga Selvi, M G Sridhar, R P Swaminathan, R Sripradha
Study Type : Human Study
Additional Links
Substances : Turmeric : CK(5032) : AC(2348)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Inflammation : CK(3240) : AC(882), Oxidative Stress : CK(3871) : AC(1382)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682), Hypoglycemic Agents : CK(1446) : AC(342)
Additional Keywords : Significant Treatment Outcome : CK(3038) : AC(366)

A botanical extract of turmeric and white mulberry acted as a bradykinin receptor B1 and B2 antagonist.

Pubmed Data : J Integr Med. 2016 Jan ;14(1):60-68. PMID: 26778230
Article Published Date : Dec 31, 2015
Authors : Mesfin Yimam, Young-Chul Lee, Breanna Moore, Ping Jiao, Mei Hong, Jeong-Bum Nam, Mi-Ran Kim, Eu-Jin Hyun, Min Chu, Lidia Brownell, Qi Jia
Study Type : Animal Study
Additional Links
Substances : Turmeric : CK(5032) : AC(2348), White Mulberry : CK(11) : AC(1)
Pharmacological Actions : Analgesics : CK(1327) : AC(217), Anti-Inflammatory Agents : CK(4861) : AC(1630), Cyclooxygenase Inhibitors : CK(71) : AC(39), Lipoxygenase Inhibitors : CK(38) : AC(17)
Additional Keywords : Dose Response : CK(1056) : AC(408), Plant Extracts : CK(7645) : AC(2539)

A gel containing curcuma longa extract was efficient in treating gingivitis by reducing its inflammatory components.

Pubmed Data : J Clin Diagn Res. 2014 Dec ;8(12):ZC08-10. Epub 2014 Dec 5. PMID: 25654020
Article Published Date : Nov 30, 2014
Authors : H Nilofer Farjana, S C Chandrasekaran, Bagavad Gita
Study Type : Human Study
Additional Links
Substances : Turmeric : CK(5032) : AC(2348)
Diseases : Gingivitis : CK(253) : AC(37)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)
Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

A polysaccharide extract of Curcuma longa significantly attenuated acute and chronic inflammation in rodent models.

Pubmed Data : Antiinflamm Antiallergy Agents Med Chem. 2015 Apr 7. Epub 2015 Apr 7. PMID: 25846947
Article Published Date : Apr 06, 2015
Authors : Ramanaiah Illuri, Bharathi Bethapudi, Senthilkumar Anandhakumar, Sasikumar Murugan, Joshua Allan Joseph, Deepak Mundkinajeddu, Amit Agarwal, Chandrasekaran Chinampudur Velusami
Study Type : Animal Study
Additional Links
Substances : Turmeric : CK(5032) : AC(2348)
Diseases : Inflammation : CK(3240) : AC(882)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)
Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

An extract of turmeric and white mulberry could potentially be considered as a dietary supplement product for the management of arthritis.

Pubmed Data : Pharmacognosy Res. 2016 Apr-Jun;8(2):112-7. PMID: 27034601
Article Published Date : Mar 31, 2016
Authors : Mesfin Yimam, Young-Chul Lee, Breanna Moore, Ping Jiao, Mei Hong, Jeong-Bum Nam, Mi-Ran Kim, Tae-Woo Kim, Hyun-Jin Kim, Eu-Jin Hyun, Min Chu, Lidia Brownell, Qi Jia
Study Type : Animal Study
Additional Links
Substances : Turmeric : CK(5032) : AC(2348), White Mulberry : CK(11) : AC(1)
Diseases : Arthritis : CK(1964) : AC(312)
Pharmacological Actions : Analgesics : CK(1327) : AC(217), Anti-Inflammatory Agents : CK(4861) : AC(1630)
Additional Keywords : Natural Substances Versus Drugs : CK(1698) : AC(302), Plant Extracts : CK(7645) : AC(2539)
Problem Substances : Ibuprofen : CK(195) : AC(24)

Combined treatment of curcumin with low doses of prednisolone may find therapeutic use in arthritis.

Pubmed Data : J Pharm Pharmacol. 2014 Jan ;66(1):133-44. Epub 2013 Oct 21. PMID: 24138213
Article Published Date : Dec 31, 2013
Authors : Madhusudana Kuncha, Vegi Ganga Modi Naidu, Bidya Dhar Sahu, Shankar Ganesh Gadepalli, Ramakrishna Sistla
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Arthritis : CK(1964) : AC(312)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682), Interleukin-1 beta downregulation : CK(478) : AC(205), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)
Additional Keywords : Natural Substance/Drug Synergy : CK(352) : AC(142), Plant Extracts : CK(7645) : AC(2539)

Curcumin could have a role in promoting neural function recovery after SCI by the joint inhibition of the intracellular and extracellular components of glial scar.

Pubmed Data : J Surg Res. 2015 May 1 ;195(1):235-45. Epub 2015 Jan 7. PMID: 25661742
Article Published Date : Apr 30, 2015
Authors : Jichao Yuan, Mingming Zou, Xin Xiang, Haitao Zhu, Weihua Chu, Wei Liu, Fei Chen, Jiangkai Lin
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Spinal Cord Injuries : CK(139) : AC(46)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-6 Downregulation : CK(1137) : AC(354), NF-kappaB Inhibitor : CK(1114) : AC(694), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)
Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Curcumin has a wide range of potential anti-obesity properties.

Pubmed Data : Eur J Nutr. 2011 Apr ;50(3):151-61. Epub 2011 Mar 27. PMID: 21442412
Article Published Date : Apr 01, 2011
Authors : Adeeb Shehzad, Taewook Ha, Fazli Subhan, Young Sup Lee
Study Type : Review
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Metabolic Syndrome X : CK(916) : AC(158), Obesity : CK(3022) : AC(467)
Pharmacological Actions : Adiponectin upregulation : CK(51) : AC(11), Anti-Inflammatory Agents : CK(4861) : AC(1630), Leptin Down-Regulation : CK(13) : AC(3)
Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Curcumin, silybin phytosome® and α-R-lipoic acid may confer therapeutic efficacy against chronic hepatitis.

Pubmed Data : Basic Clin Pharmacol Toxicol. 2015 Oct 12. Epub 2015 Oct 12. PMID: 26457982
Article Published Date : Oct 11, 2015
Authors : Shimaa O Ali, Hebatallah A Darwish, Nabila A Ismail
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid : CK(476) : AC(116), Curcumin : CK(4803) : AC(2175)
Diseases : Chronic Hepatitis : CK(12) : AC(2)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682)
Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Extracts of turmeric play an important role in the regulation of inflammatory reactions and oxidative stress occurring in the overweight patients.

Pubmed Data : Curr Med Chem. 2016 Nov 17. Epub 2016 Nov 17. PMID: 27855627
Article Published Date : Nov 16, 2016
Authors : Agata Jarząb, Wirginia Kukula-Koch
Study Type : Review
Additional Links
Substances : Turmeric : CK(5032) : AC(2348)
Diseases : Inflammation : CK(3240) : AC(882), Obesity : CK(3022) : AC(467), Overweight : CK(3320) : AC(544)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682)
Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Oral administration of Curcuma longa associated with white pepper at doses that can be extrapolated to human exposure upon supplementation improves pro-inflammatory disorders.

Pubmed Data : PLoS One. 2013 ;8(11):e81252. Epub 2013 Nov 19. PMID: 24260564
Article Published Date : Dec 31, 2012
Authors : Audrey M Neyrinck, Maud Alligier, Patrick B Memvanga, Elodie Névraumont, Yvan Larondelle, Véronique Préat, Patrice D Cani, Nathalie M Delzenne
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Piperine : CK(114) : AC(60), White Pepper : CK(10) : AC(1)
Diseases : High Fat Diet : CK(212) : AC(103), Inflammation : CK(3240) : AC(882), Obesity : CK(3022) : AC(467)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), NF-kappaB Inhibitor : CK(1114) : AC(694)
Additional Keywords : Dietary Concentrations : CK(95) : AC(23), Increased Bioavailability : CK(42) : AC(17), Plant Extracts : CK(7645) : AC(2539)

Oral administration of turmeric anthocyanin extract in O. viverrini-infected hamsters resulted in reduced inflammatory cells and periductal fibrosis.

Pubmed Data : Food Chem Toxicol. 2014 Dec ;74:206-15. PMID: 25447758
Article Published Date : Nov 30, 2014
Authors : Kitti Intuyod, Aroonsri Priprem, Wanwisa Limphirat, Lakhanawan Charoensuk, Porntip Pinlaor, Chawalit Pairojkul, Kamol Lertrat, Somchai Pinlaor
Study Type : Animal Study
Additional Links
Substances : Turmeric : CK(5032) : AC(2348)
Diseases : Flukes : CK(10) : AC(5), Parasitic Diseases : CK(60) : AC(26)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682), Hepatoprotective : CK(1387) : AC(594)
Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Turmeric contains compounds which have potent anti-amyloidogenic effects indicating their value for Alzheimer disease.

Pubmed Data : Curr Alzheimer Res. 2009 Dec;6(6):564-71. PMID: 19715544
Article Published Date : Dec 01, 2009
Authors : R Douglas Shytle, Paula C Bickford, Kavon Rezai-zadeh, L Hou, Jin Zeng, Jun Tan, Paul R Sanberg, Cyndy D Sanberg, Bill Roschek, Ryan C Fink, Randall S Alberte
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Alzheimer's Disease : CK(1292) : AC(382)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)
Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Turmeric extract reduces inflammatory mediator production.

Pubmed Data : Phytomedicine. 2005 Jun;12(6-7):445-52. PMID: 16008121
Article Published Date : Jun 01, 2005
Authors : R C Lantz, G J Chen, A M Solyom, S D Jolad, B N Timmermann
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Turmeric : CK(5032) : AC(2348)
Diseases : Inflammation : CK(3240) : AC(882), Lipopolysaccharide-Induced Toxicity : CK(380) : AC(218)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Prostaglandin PGE2 downregulation : CK(96) : AC(46), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)
Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

A review focusing on the anti-inflammatory and anti-oxidant properties of curcumin and discuss its therapeutic potential in bipolar disorders.

Pubmed Data : Med Hypotheses. 2013 May ;80(5):606-12. Epub 2013 Feb 26. PMID: 23484676
Article Published Date : Apr 30, 2013
Authors : Elisa Brietzke, Rodrigo B Mansur, Andre Zugman, André F Carvalho, Danielle S Macêdo, Danielle S Cha, Vanessa C Abílio, Roger S McIntyre
Study Type : Review
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Bipolar Disorder : CK(253) : AC(30), Brain Inflammation : CK(274) : AC(145)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682), Neuroplasticity enhancement : CK(44) : AC(12), Neuroprotective Agents : CK(2360) : AC(1099)
Additional Keywords : Cytokines : CK(33) : AC(11)

Both caloric restriction and dietary curcumin can improve obesity-associated comorbidities.

Pubmed Data : PLoS One. 2015 ;10(10):e0140431. Epub 2015 Oct 16. PMID: 26473740
Article Published Date : Dec 31, 2014
Authors : Marjana Rahman Sarker, Susan Franks, Nathalie Sumien, Nopporn Thangthaeng, Frank Filipetto, Michael Forster
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Obesity : CK(3022) : AC(467)
Therapeutic Actions : Dietary Modification: Caloric Restriction : CK(44) : AC(10)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682)

Curcuma longa polyphenols protect adipose cells against oxidative stress and may improve obesity-related metabolic disorders.

Pubmed Data : Biofactors. 2016 Apr 20. Epub 2016 Apr 20. PMID: 27094023
Article Published Date : Apr 19, 2016
Authors : Axelle Septembre-Malaterre, Fanny Le Sage, Sarah Hatia, Aurélie Catan, Laurent Janci, Marie-Paule Gonthier
Study Type : In Vitro Study
Additional Links
Substances : Curcuminoids : CK(4224) : AC(2161), Turmeric : CK(5032) : AC(2348)
Diseases : Obesity : CK(3022) : AC(467)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682)

Curcumin ameliorative effects against AP through induction of apoptosis and inhibition of micro-thrombosis, inflammation, and oxidative stress.

Pubmed Data : J Biochem Mol Toxicol. 2016 Feb 10. Epub 2016 Feb 10. PMID: 26862043
Article Published Date : Feb 09, 2016
Authors : Noha M Shafik, Ghada M Abou-Fard
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Pancreatitis : CK(217) : AC(56)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682)

Curcumin and CoQ10 independently as well as in combination ameliorate chronic hyperalgesia in sickle mice.

Pubmed Data : Haematologica. 2015 Nov 6. Epub 2015 Nov 6. PMID: 26546503
Article Published Date : Nov 05, 2015
Authors : Yessenia Valverde, Barbara Benson, Mihir Gupta, Kalpna Gupta
Study Type : Transgenic Animal Study
Additional Links
Substances : Coenzyme Q10 : CK(941) : AC(140), Curcumin : CK(4803) : AC(2175)
Diseases : Brain: Microglial Activation : CK(82) : AC(53), Hyperalgesia : CK(63) : AC(24), Sickle Cell Anemia : CK(190) : AC(21)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682)

Curcumin and piperine showed strong antioxidant and protective effect against QA-induced behavioural and neurological alteration.

Pubmed Data : Pharmacology. 2016 Jan 30 ;97(3-4):151-160. Epub 2016 Jan 30. PMID: 26828892
Article Published Date : Jan 29, 2016
Authors : Shamsher Singh, Puneet Kumar
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Piperine : CK(114) : AC(60)
Diseases : Brain Inflammation : CK(274) : AC(145)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682), Neuroprotective Agents : CK(2360) : AC(1099)
Additional Keywords : Natural Substance Synergy : CK(540) : AC(249)

Curcumin attenuates retinal oxidative stress and inflammation in diabetes.

Pubmed Data : Nutr Metab (Lond). 2007;4:8. Epub 2007 Apr 16. PMID: 17437639
Article Published Date : Jan 01, 2007
Authors : Renu A Kowluru, Mamta Kanwar
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetic Retinopathy : CK(60) : AC(23)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682)

Curcumin exhibits anti-inflammatory properties in rat brain homegenates.

Pubmed Data : Mol Cell Biochem. 1994 Nov 9;140(1):73-9. PMID: 7877600
Article Published Date : Nov 09, 1994
Authors : D V Rajakumar, M N Rao
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Brain Inflammation : CK(274) : AC(145), Lipid Peroxidation : CK(695) : AC(255)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682)

Curcumin has a promising role as a cardioprotective agent against palmitate and high fat diet mediated cardiac dysfunction.

Pubmed Data : J Mol Cell Cardiol. 2015 Feb ;79:1-12. Epub 2014 Oct 16. PMID: 25444713
Article Published Date : Jan 31, 2015
Authors : Chunlai Zeng, Peng Zhong, Yunjie Zhao, Karvannan Kanchana, Yali Zhang, Zia A Khan, Subrata Chakrabarti, Lianpin Wu, Jingying Wang, Guang Liang
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Circulating Free Fatty Acids: Elevated : CK(3) : AC(2), High Fat Diet : CK(212) : AC(103), Obesity : CK(3022) : AC(467)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682), Cardioprotective : CK(1596) : AC(409), NF-kappaB Inhibitor : CK(1114) : AC(694), Nrf2 activation : CK(177) : AC(86)

Curcumin has a protective role in cardiovascular diseases.

Pubmed Data : Int J Cardiol. 2009 Apr 3;133(2):145-51. Epub 2009 Feb 23. PMID: 19233493
Article Published Date : Apr 03, 2009
Authors : Wanwarang Wongcharoen, Arintaya Phrommintikul
Study Type : Review
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Cardiovascular Diseases : CK(7342) : AC(916)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682), Cardiovascular Agents : CK(160) : AC(24)

Curcumin inhibits neuronal apoptosis and alleviates oxidative stress and inflammation in neurons subjected to Oxyhemoglobin.

Pubmed Data : Brain Res Bull. 2015 Nov 10 ;120:34-40. Epub 2015 Nov 10. PMID: 26551062
Article Published Date : Nov 09, 2015
Authors : Xia Li, Lei Zhao, Liang Yue, Haixiao Liu, Xiangmin Yang, Xinchuan Wang, Yan Lin, Yan Qu
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Subarachnoid hemorrhage : CK(60) : AC(9)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin is a potent therapeutic drug candidate for inflammatory and degenerative retinal and eye diseases.

Pubmed Data : Mol Nutr Food Res. 2013 Sep ;57(9):1557-68. Epub 2013 Feb 18. PMID: 23417969
Article Published Date : Aug 31, 2013
Authors : Lei-Lei Wang, Yue Sun, Kun Huang, Ling Zheng
Study Type : Review
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetic Retinopathy : CK(60) : AC(23), Glaucoma : CK(164) : AC(26), Inflammation : CK(3240) : AC(882), Macular Degeneration : CK(207) : AC(34), Retinal Diseases : CK(66) : AC(21)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682)

Curcumin may have therapeutic potential for bladder cancer patients via anti-inflammatory, antioxidant and anti-carcinogenic activities.

Pubmed Data : Oncol Rep. 2006 May;15(5):1225-31. PMID: 16596191
Article Published Date : May 01, 2006
Authors : Cheol Park, Gi Young Kim, Gun Do Kim, Byung Tae Choi, Yeong-Min Park, Yung Hyun Choi
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Turmeric : CK(5032) : AC(2348)
Diseases : Bladder Cancer : CK(349) : AC(100)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Anticarcinogenic Agents : CK(1099) : AC(519), Antioxidants : CK(7529) : AC(2682)

Curcumin possesses anti-diabetic effects and mitigates diabetes complications

Pubmed Data : Curr Top Med Chem. 2015 Jun 19. Epub 2015 Jun 19. PMID: 26088351
Article Published Date : Jun 18, 2015
Authors : Seyed Fazel Nabavi, Raman Thiagarajan, Luca Rastrelli, Maria Daglia, Eduardo Sobarzo-Sanchez, Heshmatollah Alinezhad, Seyed Mohammad Nabavi
Study Type : Review
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Diabetic Complications : CK(1563) : AC(333)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682)
Additional Keywords : Advanced Glycation End Products : CK(10) : AC(1)

Curcumin protected the liver from chronic-ethanol induced injury through attenuating oxidative stress

Pubmed Data : Pharmacogn Mag. 2015 Oct-Dec;11(44):707-715. PMID: 26600714
Article Published Date : Sep 30, 2015
Authors : Zhang E Xiong, Wei Guo Dong, Bao Ying Wang, Qiao Yun Tong, Zhong Yan Li
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Alcoholic Liver Disease : CK(152) : AC(61)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682), Hepatoprotective : CK(1387) : AC(594), Nrf2 activation : CK(177) : AC(86)

Curcumin protects glial cells and promotes a microglial anti-inflammatory phenotype by a mechanism that implicates HO-1 induction.

Pubmed Data : Mol Nutr Food Res. 2015 Sep ;59(9):1690-700. Epub 2015 Jun 30. PMID: 26047311
Article Published Date : Aug 31, 2015
Authors : Esther Parada, Izaskun Buendia, Elisa Navarro, Carlos Avendaño, Javier Egea, Manuela G López
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Brain: Oxidative Stress : CK(79) : AC(46), Brain Inflammation : CK(274) : AC(145)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682), Neuroprotective Agents : CK(2360) : AC(1099), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin protects intestinal mucosal barrier function of rat enteritis.

Pubmed Data : PLoS One. 2010;5(9):e12969. Epub 2010 Sep 24. PMID: 20885979
Article Published Date : Jan 01, 2010
Authors : Wei-Bing Song, Yuan-Yuan Wang, Fan-Su Meng, Qing-Hua Zhang, Jian-Ying Zeng, Li-Ping Xiao, Xin-Pei Yu, Dan-dan Peng, Lei Su, Bing Xiao, Zhen-Shu Zhang
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Intestinal Permeability : CK(245) : AC(60)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682), Gastroprotective : CK(155) : AC(73)

Curcumin reduced or eliminated colonic tumor burden with limited effects on mucosal immune responses.

Pubmed Data : Inflamm Bowel Dis. 2015 Jul 25. Epub 2015 Jul 25. PMID: 26218141
Article Published Date : Jul 24, 2015
Authors : Rita-Marie T McFadden, Claire B Larmonier, Kareem W Shehab, Monica Midura-Kiela, Rajalakshmy Ramalingam, Christy A Harrison, David G Besselsen, John H Chase, J Gregory Caporaso, Christian Jobin, Fayez K Ghishan, Pawel R Kiela
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Colitis : CK(255) : AC(111), Colon Cancer: Prevention : CK(178) : AC(57)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Anticarcinogenic Agents : CK(1099) : AC(519), Antioxidants : CK(7529) : AC(2682), Chemopreventive : CK(2835) : AC(787)
Additional Keywords : Microbiota : CK(396) : AC(101)

Curcumin significantly ameliorates disease symptoms in a Drosophila model of Huntington's disease.

Pubmed Data : Sci Rep. 2016 ;6:18736. Epub 2016 Jan 5. PMID: 26728250
Article Published Date : Dec 31, 2015
Authors : Anjalika Chongtham, Namita Agrawal
Study Type : Insect Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Huntington Disease : CK(91) : AC(36)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682)

Curcumin treatment attenuates lipopolysaccharide induced liver injury.

Pubmed Data : Biomed Pharmacother. 2016 Jul 6 ;83:302-313. Epub 2016 Jul 6. PMID: 27393927
Article Published Date : Jul 05, 2016
Authors : Wenhui Zhong, Kejian Qian, Jibin Xiong, Ke Ma, Aizhong Wang, Yan Zou
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Lipopolysaccharide-Induced Toxicity : CK(380) : AC(218), Sepsis : CK(197) : AC(54)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682), Hepatoprotective : CK(1387) : AC(594)

NPs-Cur enhance the action of curcumin on several pathways implicated in the pathophysiology of Alzheimer's disease.

Pubmed Data : Mol Pharm. 2015 Dec 23. Epub 2015 Dec 23. PMID: 26618861
Article Published Date : Dec 22, 2015
Authors : Ghislain Djiokeng Paka, Sihem Doggui, Ahlem Zaghmi, Ramia Safar, Lé Dao, Andreas Reisch, Andrey Klymchenko, V Gaëlle Roullin, Olivier Joubert, Charles Ramassamy
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Alzheimer's Disease : CK(1292) : AC(382)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682), Neuroprotective Agents : CK(2360) : AC(1099)

Phytochemicals have the potential of modulating various molecular processes, including signaling pathways involved in the development and progression of tumors.

Pubmed Data : Onco Targets Ther. 2015 ;8:2053-66. Epub 2015 Aug 6. PMID: 26273208
Article Published Date : Dec 31, 2014
Authors : Roxana Cojocneanu Petric, Cornelia Braicu, Lajos Raduly, Oana Zanoaga, Nicolae Dragos, Paloma Monroig, Dan Dumitrascu, Ioana Berindan-Neagoe
Study Type : Review
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), EGCG (Epigallocatechin gallate) : CK(1956) : AC(314), Genistein : CK(515) : AC(228)
Diseases : Breast Cancer : CK(3592) : AC(1064)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Anticarcinogenic Agents : CK(1099) : AC(519), Antioxidants : CK(7529) : AC(2682), Apoptotic : CK(2958) : AC(2075), Chemotherapeutic : CK(397) : AC(152), MicroRNA modulator : CK(264) : AC(145)

Polymerized nano-curcumin has significant effects on the EAE scores and myelin repair mechanisms in an animal model of multiple sclerosis.

Pubmed Data : Neuropharmacology. 2015 Dec ;99:156-67. Epub 2015 Jul 23. PMID: 26211978
Article Published Date : Nov 30, 2015
Authors : Maryam Mohajeri, Majid Sadeghizadeh, Farhood Najafi, Mohammad Javan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Demyelinating Diseases : CK(1671) : AC(332), Multiple Sclerosis : CK(964) : AC(184)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682), Neuroprotective Agents : CK(2360) : AC(1099), Remyelination : CK(2) : AC(1)
Additional Keywords : Gene Expression Regulation : CK(431) : AC(214)

Short-term adjunctive therapy with curcuminoids can suppress systemic inflammation in patients suffering from SM-induced chronic pulmonary complications.

Pubmed Data : Drug Res (Stuttg). 2014 Sep 30. Epub 2014 Sep 30. PMID: 25268878
Article Published Date : Sep 29, 2014
Authors : Y Panahi, M Ghanei, S Bashiri, A Hajihashemi, A Sahebkar
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Chemical Weapon Agent Injury : CK(26) : AC(6), Chemical Weapon Agent Injury: Sulfur Mustard : CK(31) : AC(4)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682)

These findings indicated that intranasal curcumin treatment effectively helped promote diabetic corneal epithelial/nerve wound healing.

Pubmed Data : Sci Rep. 2016 ;6:29753. Epub 2016 Jul 11. PMID: 27405815
Article Published Date : Dec 31, 2015
Authors : Chuanlong Guo, Mengshuang Li, Xia Qi, Guiming Lin, Fenghua Cui, Fengjie Li, Xianggen Wu
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetic Complications : CK(1563) : AC(333), Wound Healing: Delayed : CK(74) : AC(29)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682)

This review focuses on the different targets of curcumin to treat cancer.

Pubmed Data : Asian Pac J Cancer Prev. 2016 ;17(6):2735-9. PMID: 27356682
Article Published Date : Dec 31, 2015
Authors : Muhammad Imran Qadir, Syeda Tahira Qousain Naqvi, Syed Aun Muhammad
Study Type : Review
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Cancers: All : CK(14773) : AC(4596)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Anticarcinogenic Agents : CK(1099) : AC(519), Antioxidants : CK(7529) : AC(2682), Chemopreventive : CK(2835) : AC(787)

Using curcumin effectively prevented intestinal ischemia reperfusion injury induced lung injury.

Pubmed Data : Int J Clin Exp Pathol. 2015 ;8(4):3451-9. Epub 2015 Apr 1. PMID: 26097529
Article Published Date : Dec 31, 2014
Authors : Zhe Fan, Jihong Yao, Yang Li, Xiaowei Hu, Huizhu Shao, Xiaofeng Tian
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Intestinal Ischemia : CK(12) : AC(6)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682), NF-kappaB Inhibitor : CK(1114) : AC(694)

A combination of curcumin and paclitaxel exhibited synergistic anti-proliferative and pro-apoptosis effects on Hep3B cells.

Pubmed Data : J Recept Signal Transduct Res. 2015 Jun 25:1-8. Epub 2015 Jun 25. PMID: 26108226
Article Published Date : Jun 24, 2015
Authors : Mingjie Zhou, Zhaohui Li, Ziwu Han, Nan Tian
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Kidney Cancer : CK(148) : AC(42)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075), Chemosensitizer : CK(394) : AC(286), NF-kappaB Inhibitor : CK(1114) : AC(694)
Additional Keywords : Chemothapeutic Synergy: Paclitaxel : CK(32) : AC(23)

Combination of α-tomatine and curcumin more potently inhibited the growth of PC-3 tumors than either agent alone.

Pubmed Data : PLoS One. 2015;10(12):e0144293. Epub 2015 Dec 2. PMID: 26630272
Article Published Date : Dec 31, 2014
Authors : Huarong Huang, Xuan Chen, Dongli Li, Yan He, Yu Li, Zhiyun Du, Kun Zhang, Robert DiPaola, Susan Goodin, Xi Zheng
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Tomato : CK(557) : AC(109)
Diseases : Prostate Cancer : CK(1499) : AC(438)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075), Bcl-2 protein down-regulation : CK(198) : AC(131), NF-kappaB Inhibitor : CK(1114) : AC(694)
Additional Keywords : Natural Substance Synergy : CK(540) : AC(249)

Curcumin could be used as an adjuvant agent to chemotherapy in treatment of triple negative breast cancer.

Pubmed Data : Biomed Res Int. 2015 ;2015:878134. Epub 2015 Mar 23. PMID: 25879038
Article Published Date : Dec 31, 2014
Authors : Sabrina Bimonte, Antonio Barbieri, Giuseppe Palma, Domenica Rea, Antonio Luciano, Massimiliano D'Aiuto, Claudio Arra, Francesco Izzo
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Breast Cancer : CK(3592) : AC(1064), Breast Cancer: Triple Negative : CK(262) : AC(144)
Pharmacological Actions : Angiogenesis Inhibitors : CK(114) : AC(62), Anti-Inflammatory Agents : CK(4861) : AC(1630), Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075), NF-kappaB Inhibitor : CK(1114) : AC(694)

Curcumin in combination with visible light inhibits tumor growth in a xenograft tumor model.

Pubmed Data : Int J Cancer. 2009 Mar 15;124(6):1422-8. PMID: 19035461
Article Published Date : Mar 15, 2009
Authors : Jadranka Dujic, Stefan Kippenberger, Ana Ramirez-Bosca, Joaquin Diaz-Alperi, Jürgen Bereiter-Hahn, Roland Kaufmann, August Bernd, Matthias Hofmann
Study Type : Transgenic Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Epithelial Neoplasms: Malignant : CK(3) : AC(2)
Therapeutic Actions : Light Therapy : CK(154) : AC(31)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075)

Curcumin may support the regeneration of articular cartilage.

Pubmed Data : Arthritis Res Ther. 2010;12(4):R127. Epub 2010 Jul 1. PMID: 20594343
Article Published Date : Jan 01, 2010
Authors : Constanze Buhrmann, Ali Mobasheri, Ulrike Matis, Mehdi Shakibaei
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Cartilage Diseases : CK(6) : AC(5), Osteoarthritis : CK(770) : AC(115), Rheumatoid Arthritis : CK(706) : AC(117)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Apoptotic : CK(2958) : AC(2075), Interleukin-1 beta downregulation : CK(478) : AC(205), NF-kappaB Inhibitor : CK(1114) : AC(694)

Curcumin targets numerous therapeutically important cancer signalling pathways.

Pubmed Data : Tumour Biol. 2016 Jul 28. Epub 2016 Jul 28. PMID: 27468716
Article Published Date : Jul 27, 2016
Authors : Pandima Devi Kasi, Rajavel Tamilselvam, Krystyna Skalicka-Woźniak, Seyed Fazel Nabavi, Maria Daglia, Anupam Bishayee, Hamidreza Pazoki-Toroudi, Seyed Mohammad Nabavi
Study Type : Review
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Cancers: All : CK(14773) : AC(4596)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075), Tumor Suppressor Protein p53 Upregulation : CK(293) : AC(202), Wnt/β-catenin pathway down-regulation : CK(49) : AC(27)
Additional Keywords : Tumor Microenvironment : CK(29) : AC(21)

This review highlights specific biological processes that could be exploited as targets for the prevention and therapy of cancer.

Pubmed Data : Semin Cancer Biol. 2015 Apr 10. Epub 2015 Apr 10. PMID: 25865775
Article Published Date : Apr 09, 2015
Authors : Stephanie C Casey, Amedeo Amedei, Katia Aquilano, Asfar S Azmi, Fabian Benencia, Dipita Bhakta, Alan E Bilsland, Chandra S Boosani, Sophie Chen, Maria Rosa Ciriolo, Sarah Crawford, Hiromasa Fujii, Alexandros G Georgakilas, Gunjan Guha, Dorota Halicka, William G Helferich, Petr Heneberg, Kanya Honoki, W Nicol Keith, Sid P Kerkar, Sulma I Mohammed, Elena Niccolai, Somaira Nowsheen, H P Vasantha Rupasinghe, Abbas Samadi, Neetu Singh, Wamidh H Talib, Vasundara Venkateswaran, Richard L Whelan, Xujuan Yang, Dean W Felsher
Study Type : Review
Additional Links
Substances : Berberine : CK(325) : AC(166), Curcumin : CK(4803) : AC(2175), EGCG (Epigallocatechin gallate) : CK(1956) : AC(314), Genistein : CK(515) : AC(228), Naringenin : CK(53) : AC(37), Piperine : CK(114) : AC(60), Resveratrol : CK(1283) : AC(746)
Diseases : Cancers: All : CK(14773) : AC(4596)
Pharmacological Actions : Angiogenesis Inhibitors : CK(114) : AC(62), Anti-Inflammatory Agents : CK(4861) : AC(1630), Anti-metastatic : CK(634) : AC(414), Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075)
Additional Keywords : Tumor Microenvironment : CK(29) : AC(21)

Curcumin attenuates the inflammatory response in collagen-induced arthritis.

Pubmed Data : Int Immunopharmacol. 2010 May;10(5):605-10. Epub 2010 Feb 23. PMID: 20188213
Article Published Date : May 01, 2010
Authors : Dong-Oh Moon, Mun-Ok Kim, Yung Hyun Choi, Yung-Min Park, Gi-Young Kim
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Arthritis : CK(1964) : AC(312)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antiproliferative : CK(2546) : AC(1685), Interleukin-1 beta downregulation : CK(478) : AC(205)

Curcumin blocks the activation of pancreatic stellate cells associated with inflammation and fibrosis.

Pubmed Data : J Cell Biochem. 2006 Apr 1;97(5):1080-93. PMID: 16294327
Article Published Date : Apr 01, 2006
Authors : Atsushi Masamune, Noriaki Suzuki, Kazuhiro Kikuta, Masahiro Satoh, Kennichi Satoh, Tooru Shimosegawa
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Pancreatic Diseases : CK(16) : AC(4), Pancreatic Fibrosis : CK(1) : AC(1), Pancreatitis : CK(217) : AC(56)
Pharmacological Actions : Anti-Fibrotic : CK(46) : AC(29), Anti-Inflammatory Agents : CK(4861) : AC(1630), Antiproliferative : CK(2546) : AC(1685), NF-kappaB Inhibitor : CK(1114) : AC(694)

Curcumin exhibits anti-inflammatory and anti-atherosclerotic properties.

Pubmed Data : Eur J Pharmacol. 1992 Oct 20;221(2-3):381-4. PMID: 1426014
Article Published Date : Oct 20, 1992
Authors : H C Huang, T R Jan, S F Yeh
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Atherosclerosis : CK(601) : AC(150), Inflammation : CK(3240) : AC(882), Restenosis : CK(43) : AC(15)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antiproliferative : CK(2546) : AC(1685)

Curcumin improves sclerosing cholangitis in mice.

Pubmed Data : Gut. 2010 Apr;59(4):521-30. PMID: 20332524
Article Published Date : Apr 01, 2010
Authors : Anna Baghdasaryan, Thierry Claudel, Astrid Kosters, Judith Gumhold, Dagmar Silbert, Andrea Thüringer, Katharina Leski, Peter Fickert, Saul J Karpen, Michael Trauner
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Cholangitis : CK(2) : AC(1)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antiproliferative : CK(2546) : AC(1685)

The combination of curcumin with LED blue light united red light irradiation can attain a higher efficiency of regulating proliferation and apoptosis in skin keratinocytes.

Pubmed Data : PLoS One. 2015;10(9):e0138754. Epub 2015 Sep 18. PMID: 26382065
Article Published Date : Dec 31, 2014
Authors : Tianhui Niu, Yan Tian, Qing Cai, Qu Ren, Lizhao Wei
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Inflammation : CK(3240) : AC(882), Psoriasis : CK(352) : AC(65)
Therapeutic Actions : Light-Emitting Diodes (LEDs) Therapy : CK(180) : AC(41)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antiproliferative : CK(2546) : AC(1685)

This reviews the many different molecular aspects of curcumin in breast cancer treatments.

Pubmed Data : Anticancer Agents Med Chem. 2015 May 14 ;15(5):647-56. PMID: 25553436
Article Published Date : May 13, 2015
Authors : Parveen Kumar, Almesh Kadakol, Prashanth Krishna Shasthrula, Nitin Arunrao Mundhe, Vinayak Sudhir Jamdade, Chandana C Barua, Anil Bhanudas Gaikwad
Study Type : Review
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Breast Cancer : CK(3592) : AC(1064)
Pharmacological Actions : Angiogenesis Inhibitors : CK(114) : AC(62), Anti-Inflammatory Agents : CK(4861) : AC(1630), Anti-metastatic : CK(634) : AC(414), NF-kappaB Inhibitor : CK(1114) : AC(694)
Additional Keywords : Natural Substance/Drug Synergy : CK(352) : AC(142)

"Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis."

Pubmed Data : Biofactors. 2012 Dec 11. Epub 2012 Dec 11. PMID: 23233214
Article Published Date : Dec 10, 2012
Authors : Akira Murakami, Ikuyo Furukawa, Shingo Miyamoto, Takuji Tanaka, Hajime Ohigashi
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Turmerones : CK(9) : AC(6)
Diseases : Colon Cancer: Prevention : CK(178) : AC(57)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Chemopreventive : CK(2835) : AC(787)

A combination of curcumin and fennel essential oil significantly improved symptoms and quality of life in IBS patients over 30 days.

Pubmed Data : J Gastrointestin Liver Dis. 2016 Jun ;25(2):151-7. PMID: 27308645
Article Published Date : May 31, 2016
Authors : Piero Portincasa, Leonilde Bonfrate, Maria Lia Lia Scribano, Anna Kohn, Nicola Caporaso, Davide Festi, Maria Chiara Campanale, Teresa Di Rienzo, Maria Guarino, Martina Taddia, Maria Vittoria Fogli, Maria Grimaldi, Antonio Gasbarrini
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Fennel : CK(150) : AC(23)
Diseases : Irritable Bowel Syndrome : CK(720) : AC(93)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)
Additional Keywords : Essential Oils : CK(181) : AC(69), Natural Substance Synergy : CK(540) : AC(249), Significant Treatment Outcome : CK(3038) : AC(366)

A complex of curcumin and phosphatidylcholine is effective in reducing the symptoms of ostearthritis.

Pubmed Data : Altern Med Rev. 2010 Dec;15(4):337-44. PMID: 21194249
Article Published Date : Dec 01, 2010
Authors : Gianni Belcaro, Maria Rosaria Cesarone, Mark Dugall, Luciano Pellegrini, Andrea Ledda, Maria Giovanna Grossi, Stefano Togni, Giovanni Appendino
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Phosphatidylcholine : CK(101) : AC(22)
Diseases : Osteoarthritis : CK(770) : AC(115)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

A novel demethylated curcuminoid exhibits neuroprotective and anti-inflammatory properties.

Pubmed Data : Antioxid Redox Signal. 2009 Mar;11(3):449-68. PMID: 18724833
Article Published Date : Mar 01, 2009
Authors : Savita Khanna, Han-A Park, Chandan K Sen, Trimurtulu Golakoti, Krishanu Sengupta, Somepalli Venkateswarlu, Sashwati Roy
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Neurodegenerative Diseases : CK(3376) : AC(850)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Neuroprotective Agents : CK(2360) : AC(1099)

A variety of natural substances have preventive potential in osteoarthritis and rheumatoid arthritis.

Pubmed Data : Arthritis Res Ther. 2011 Feb 3;13(1):102. Epub 2011 Feb 3. PMID: 21345249
Article Published Date : Feb 03, 2011
Authors : Sarah Khalifé, Muhammad Zafarullah
Study Type : Review
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), EGCG (Epigallocatechin gallate) : CK(1956) : AC(314), Pomegranate : CK(499) : AC(168), Resveratrol : CK(1283) : AC(746)
Diseases : Osteoarthritis : CK(770) : AC(115), Rheumatoid Arthritis : CK(706) : AC(117)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Administering curcumin may alleviate cerebral inflammation resulting from intracerebral hemorrhage.

Pubmed Data : Neurosci Lett. 2016 Mar 26 ;620:74-82. Epub 2016 Mar 26. PMID: 27026486
Article Published Date : Mar 25, 2016
Authors : Wei Liu, Jichao Yuan, Haitao Zhu, Xuan Zhang, Lan Li, Xiaojun Liao, Zexian Wen, Yaxing Chen, Hua Feng, Jiangkai Lin
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Brain Inflammation : CK(274) : AC(145), Cerebral Ischemia : CK(229) : AC(77)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interferon Gamma Reducer : CK(58) : AC(24), Interleukin-17 downregulation : CK(39) : AC(13)

Boswellia serrata and Curcuma longa dietary supplementation alleviated short and partially mid-term pain.

Pubmed Data : Musculoskelet Surg. 2015 May 10. Epub 2015 May 10. PMID: 25957549
Article Published Date : May 09, 2015
Authors : G Merolla, F Dellabiancia, A Ingardia, P Paladini, G Porcellini
Study Type : Human Study
Additional Links
Substances : Boswellia : CK(111) : AC(26), Turmeric : CK(5032) : AC(2348)
Diseases : Tendon Injury : CK(4) : AC(2)
Pharmacological Actions : Analgesics : CK(1327) : AC(217), Anti-Inflammatory Agents : CK(4861) : AC(1630)

Both chlorhexidine and turmeric can be used as an adjunct to mechanical means in preventing and treating gingivitis.

Pubmed Data : Complement Ther Clin Pract. 2016 Nov ;25:13-17. Epub 2016 Aug 2. PMID: 27863601
Article Published Date : Oct 31, 2016
Authors : Karissa A Stoyell, Jennifer L Mappus, Mona A Gandhi
Study Type : Review
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Turmeric : CK(5032) : AC(2348)
Diseases : Gingivitis : CK(253) : AC(37)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antimicrobial : CK(293) : AC(128), Prophylactic Agents : CK(129) : AC(31)

Capsaicin, curcumin and cod liver reduce inflammation in rat peritoneal macrophages.

Pubmed Data : Biochim Biophys Acta. 1994 Nov 10;1224(2):255-63. PMID: 7981240
Article Published Date : Nov 10, 1994
Authors : B Joe, B R Lokesh
Study Type : In Vitro Study
Additional Links
Substances : Capsaicin : CK(129) : AC(55), Curcumin : CK(4803) : AC(2175), Omega-3 Fatty Acids : CK(4090) : AC(396)
Diseases : Inflammation : CK(3240) : AC(882)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcuma and karkade could ameliorate the immunological disturbances caused by repeated exposure to the house dust mite’s faeces.

Pubmed Data : Allergol Immunopathol (Madr). 2015 May 13. Epub 2015 May 13. PMID: 25982575
Article Published Date : May 12, 2015
Authors : Bahaa K A Abdel-Salam, Nagiba I A Shoker, Ahmed M R Mohamad
Study Type : Animal Study
Additional Links
Substances : Hibiscus : CK(36) : AC(7), Turmeric : CK(5032) : AC(2348)
Diseases : Allergic Airway Diseases : CK(69) : AC(25)
Pharmacological Actions : Anti-Allergic Agents : CK(167) : AC(61), Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin (from Turmeric) has has neuroprotective properties mostly due to its anti-inflammatory effects.

Pubmed Data : Pharmazie. 2007 Dec;62(12):937-42. PMID: 18214347
Article Published Date : Dec 01, 2007
Authors : Hae Sung Lee, Ki Kyung Jung, Jae Youl Cho, Man Hee Rhee, Sungyoul Hong, Moosik Kwon, Seung Hee Kim, Seog Youn Kang
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Brain Diseases : CK(19) : AC(8)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin (Turmeric) may benefit Multiple Sclerosis by blocking an inflammatory mediator.

Pubmed Data : J Immunol. 2002 Jun 15;168(12):6506-13. PMID: 12055272
Article Published Date : Jun 15, 2002
Authors : Chandramohan Natarajan, John J Bright
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Multiple Sclerosis : CK(964) : AC(184)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin administered through nasal route might prove therapeutically efficient in inhibiting allergic airway inflammation.

Pubmed Data : Allergol Immunopathol (Madr). 2016 Apr 1. Epub 2016 Apr 1. PMID: 27046748
Article Published Date : Mar 31, 2016
Authors : Subhashini, P S Chauhan, R Singh
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Allergic Airway Diseases : CK(69) : AC(25), Asthma : CK(1157) : AC(190)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin alleviates matrix metalloproteinases associated with inflammation during eradication of H. pylori infection.

Pubmed Data : PLoS One. 2011;6(1):e16306. Epub 2011 Jan 21. PMID: 21283694
Article Published Date : Jan 01, 2011
Authors : Parag Kundu, Ronita De, Ipsita Pal, Asish K Mukhopadhyay, Dhira Rani Saha, Snehasikta Swarnakar
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Helicobacter Pylori Infection : CK(506) : AC(104)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Matrix metalloproteinase-3 (MMP-3) inhibitor : CK(61) : AC(18), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(212) : AC(128)

Curcumin alone or in combination with clarithromycin showed a much more significant reduction in neutrophil influx along with reduced levels of various inflammatory parameters.

Pubmed Data : J Infect Dev Ctries. 2014 Jul ;8(7):838-44. Epub 2014 Jul 14. PMID: 25022293
Article Published Date : Jun 30, 2014
Authors : Shruti Bansal, Sanjay Chhibber
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Klebsiella Infections : CK(70) : AC(32), Klesiella Pneumonia Infection : CK(2) : AC(1)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Immunomodulatory : CK(1287) : AC(358)

Curcumin ameliorated skeletal muscle atrophy in DM mice by inhibiting protein ubiquitination, inflammatory cytokines and oxidative stress.

Pubmed Data : Exp Physiol. 2015 May 22. Epub 2015 May 22. PMID: 25998196
Article Published Date : May 21, 2015
Authors : Taisuke Ono, Shingo Takada, Shintaro Kinugawa, Tadashi Suga, Mochamad A Sobirin, Kagami Hirabayashi, Masashige Takahashi, Arata Fukushima, Tsuneaki Homma, Takashi Yokota, Shouji Matsushima, Hiroyuki Tsutsui
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes: Oxidative Stress : CK(131) : AC(40), Diabetes Mellitus: Type 1 : CK(1130) : AC(301), Inflammation : CK(3240) : AC(882), Muscle Atrophy : CK(105) : AC(35)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-1 beta downregulation : CK(478) : AC(205), NF-kappaB Inhibitor : CK(1114) : AC(694), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)
Additional Keywords : Significant Treatment Outcome : CK(3038) : AC(366)

Curcumin and Apigenin might delay the onset of Alzheimer's disease or slow down its progression.

Pubmed Data : Neural Regen Res. 2015 Aug ;10(8):1181-5. PMID: 26487830
Article Published Date : Jul 31, 2015
Authors : Madhuri Venigalla, Erika Gyengesi, Gerald Münch
Study Type : Review
Additional Links
Substances : Apigenin : CK(158) : AC(101), Curcumin : CK(4803) : AC(2175)
Diseases : Alzheimer's Disease : CK(1292) : AC(382), Brain Inflammation : CK(274) : AC(145)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin and Boswellia serrata are safe and tolerable and helped to improvethe levels of an inflammatory cytokine (IL-6).

Pubmed Data : J Complement Integr Med. 2013 ;10(1):1-10. Epub 2013 Jul 1. PMID: 23828329
Article Published Date : Dec 31, 2012
Authors : Rodney G Bowden, Jennifer J Moreillon, Erika Deike, Jackson Griggs, Ron Wilson, Brian Shelmadine, Matt Cooke, Alexander Beaujean
Study Type : Human Study
Additional Links
Substances : Boswellia : CK(111) : AC(26), Turmeric : CK(5032) : AC(2348)
Diseases : Chronic Kidney Disease (CKD) : CK(147) : AC(23)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-6 Downregulation : CK(1137) : AC(354)
Additional Keywords : Substance Combination : CK(20) : AC(2)

Curcumin and capsaicin treatments attenuated hepatic fat accumulation and increased leptin levels related to inflammation.

Pubmed Data : Arch Physiol Biochem. 2015 Dec 26:1-29. Epub 2015 Dec 26. PMID: 26706937
Article Published Date : Dec 25, 2015
Authors : Muhammed Seyithanoğlu, Yıldız Öner-İyidoğan, Semra Doğru-Abbasoğlu, Sevda Tanrıkulu-Küçük, Hikmet Koçak, Şule Beyhan-Özdaş, Necla Koçak-Toker
Study Type : Animal Study
Additional Links
Substances : Capsaicin : CK(129) : AC(55), Curcumin : CK(4803) : AC(2175)
Diseases : High Fat Diet : CK(212) : AC(103)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Hepatoprotective : CK(1387) : AC(594)

curcumin and its major metabolites inhibited the LPS‑induced inflammatory response via the mechanism of inhibiting NF‑κB translocation to the nucleus.

Pubmed Data : Mol Med Rep. 2015 Apr ;11(4):3087-93. Epub 2014 Dec 11. PMID: 25502175
Article Published Date : Mar 31, 2015
Authors : Feng Zhao, Yudian Gong, Yuan Hu, Minghui Lu, Jing Wang, Jianxin Dong, Daquan Chen, Lei Chen, Fenghua Fu, Feng Qiu
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Curcumin: Degradiation byproducts : CK(1) : AC(1)
Diseases : Inflammation : CK(3240) : AC(882), Lipopolysaccharide-Induced Toxicity : CK(380) : AC(218)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), NF-kappaB Inhibitor : CK(1114) : AC(694)

Curcumin attenuated neuropathic pain and down-regulated the production of spinal mature IL-1β.

Pubmed Data : Sci Rep. 2016;6:28956. Epub 2016 Jul 6. PMID: 27381056
Article Published Date : Dec 31, 2015
Authors : Shenbin Liu, Qian Li, Meng-Ting Zhang, Qi-Liang Mao-Ying, Lang-Yue Hu, Gen-Cheng Wu, Wen-Li Mi, Yan-Qing Wang
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Neuropathic Pain : CK(271) : AC(62)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-1 beta downregulation : CK(478) : AC(205)

Curcumin attenuates Concanavalin A-induced liver injury in mice.

Pubmed Data : Int Immunopharmacol. 2012 Jan ;12(1):151-7. Epub 2011 Dec 2. PMID: 22138522
Article Published Date : Dec 31, 2011
Authors : Chuan-tao Tu, Bing Han, Qun-yan Yao, Yi-an Zhang, Hong-chun Liu, Shun-cai Zhang
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Chemically-Induced Liver Damage : CK(634) : AC(255), Hepatitis: Lectin-Induced (concanavalin) : CK(8) : AC(4)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Hepatoprotective : CK(1387) : AC(594)

Curcumin attenuates inflammation in experimental colitis.

Pubmed Data : Mol Cell Biochem. 2009 Feb;322(1-2):127-35. Epub 2008 Nov 11. PMID: 19002562
Article Published Date : Feb 01, 2009
Authors : A Lubbad, M A Oriowo, I Khan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Colitis : CK(255) : AC(111)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin attenuates the development of allergic airway inflammation and hyper-responsiveness.

Pubmed Data : J Ethnopharmacol. 2010 Jul 17. Epub 2010 Jul 17. PMID: 20643202
Article Published Date : Jul 17, 2010
Authors : Se-Woong Oh, Joo-Young Cha, Ji-Eun Jung, Beom-Chol Chang, Hyo-Jung Kwon, Bo-Ram Lee, Dae-Yong Kim
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Allergic Airway Diseases : CK(69) : AC(25), Asthma : CK(1157) : AC(190), Hypersensitivity : CK(74) : AC(22)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), NF-kappaB Inhibitor : CK(1114) : AC(694)

Curcumin attenuates the organ dysfunction caused by endotoxemia in the rat.

Pubmed Data : Nutrition. 2008 Nov-Dec;24(11-12):1133-8. Epub 2008 Aug 26. PMID: 18752929
Article Published Date : Nov 01, 2008
Authors : Dilek Memis, Sevtap Hekimoglu, Atakan Sezer, Semsi Altaner, Necdet Sut, Ufuk Usta
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Endotoxemia : CK(83) : AC(43)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin attenuates the severity of premenstrual syndrome symptoms.

Pubmed Data : Complement Ther Med. 2015 Jun ;23(3):318-24. Epub 2015 Apr 9. PMID: 26051565
Article Published Date : May 31, 2015
Authors : Samira Khayat, Hamed Fanaei, Masoomeh Kheirkhah, Zahra Behboodi Moghadam, Amir Kasaeian, Mani Javadimehr
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Premenstrual syndrome : CK(230) : AC(23)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin can alleviate S. aureus-induced acute lung injury through multiple pathways.

Pubmed Data : Clin Respir J. 2015 Jan ;9(1):87-97. Epub 2014 Mar 20. PMID: 24460792
Article Published Date : Dec 31, 2014
Authors : Feng Xu, Ran Diao, Jin Liu, Yanhua Kang, Xuanding Wang, Liyun Shi
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Staphylococcus aureus infection : CK(152) : AC(108)
Pharmacological Actions : Anti-Bacterial Agents : CK(1367) : AC(475), Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin can attenuate the downregulation of CISD2 in spinal cord injuries and LPS-treated astrocytes.

Pubmed Data : Injury. 2015 Aug 8. Epub 2015 Aug 8. PMID: 26387034
Article Published Date : Aug 07, 2015
Authors : Chai-Ching Lin, Tien-Huang Chiang, Wei-Jung Chen, Yu-Yo Sun, Yi-Hsuan Lee, Muh-Shi Lin
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Brain Inflammation : CK(274) : AC(145), Spinal Cord Injuries : CK(139) : AC(46)
Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Anti-Inflammatory Agents : CK(4861) : AC(1630), MicroRNA modulator : CK(264) : AC(145), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin can reduce inflammation and offset some of the performance deficits associated with eccentric exercise-induced muscle damage.

Pubmed Data : Am J Physiol Regul Integr Comp Physiol. 2007 Jun;292(6):R2168-73. Epub 2007 Mar 1. PMID: 17332159
Article Published Date : Jun 01, 2007
Authors : J Mark Davis, E Angela Murphy, Martin D Carmichael, Mark R Zielinski, Claire M Groschwitz, Adrienne S Brown, J David Gangemi, Abdul Ghaffar, Eugene P Mayer
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Exercise-Induced Tissue Damage : CK(40) : AC(8), Inflammation : CK(3240) : AC(882), Muscle Soreness: Exercise-Induced : CK(164) : AC(18)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin could be a novel treatment for skin-related disorders.

Pubmed Data : J Drugs Dermatol. 2013 Oct ;12(10):1131-7. PMID: 24085048
Article Published Date : Sep 30, 2013
Authors : Tuyet A Nguyen, Adam J Friedman
Study Type : Review
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Melanoma : CK(285) : AC(149), Psoriasis : CK(352) : AC(65), Skin Cancer : CK(652) : AC(264), Squamous cell carcinoma : CK(152) : AC(67)
Pharmacological Actions : Anti-Bacterial Agents : CK(1367) : AC(475), Anti-Inflammatory Agents : CK(4861) : AC(1630)
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1905) : AC(215)

Curcumin could be of therapeutic use in the treatment of spinal cord injury.

Pubmed Data : Neurol Res Int. 2016 ;2016:9468193. Epub 2016 May 19. PMID: 27298735
Article Published Date : Dec 31, 2015
Authors : Raghavendra Sanivarapu, Vijayalakshmi Vallabhaneni, Vivek Verma
Study Type : Review
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Spinal Cord Injuries : CK(139) : AC(46)
Pharmacological Actions : Anti-Fibrotic : CK(46) : AC(29), Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin could be used for peripheral arterial disease treatment.

Pubmed Data : Med Sci Monit. 2016 ;22:2035-42. Epub 2016 Jun 15. PMID: 27302110
Article Published Date : Dec 31, 2015
Authors : Yang Liu, Lianyu Chen, Yi Shen, Tao Tan, Nanzi Xie, Ming Luo, Zhihong Li, Xiaoyun Xie
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Ischemia : CK(76) : AC(38), Peripheral Arterial Disease : CK(282) : AC(29)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Immunomodulatory : CK(1287) : AC(358), Interleukin-6 Downregulation : CK(1137) : AC(354), NF-kappaB Inhibitor : CK(1114) : AC(694), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis.

Pubmed Data : Int J Cancer. 2010 Sep 7. Epub 2010 Sep 7. PMID: 20824699
Article Published Date : Sep 07, 2010
Authors : Suksanti Prakobwong, Jarinya Khoontawad, Puangrat Yongvanit, Chawalit Pairojkul, Yusuke Hiraku, Paiboon Sithithaworn, Porntip Pinlaor, Bharat B Aggarwal, Somchai Pinlaor
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Cholangiocarcinoma : CK(96) : AC(21)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Anti-Proliferative : CK(59) : AC(52), Chemopreventive : CK(2835) : AC(787), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(212) : AC(128), Vascular Endothelial Growth Factor Inhibitors : CK(123) : AC(61)

Curcumin displays therapeutic value in an animal model of irritable bowel syndrome.

Pubmed Data : AAPS PharmSciTech. 2009;10(3):752-62. Epub 2009 Jun 3. PMID: 19495987
Article Published Date : Jan 01, 2009
Authors : Vivek R Yadav, Sarasija Suresh, Kshama Devi, Seema Yadav
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Colitis : CK(255) : AC(111), Irritable Bowel Syndrome : CK(720) : AC(93)
Pharmacological Actions : Anti-Angiogenic : CK(197) : AC(137), Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin exhibits anti-inflammatory properties in leukemia cells.

Pubmed Data : Ann N Y Acad Sci. 2009 Aug;1171:391-8. PMID: 19723081
Article Published Date : Aug 01, 2009
Authors : Marie-Helene Teiten, Serge Eifes, Simone Reuter, Annelyse Duvoix, Mario Dicato, Marc Diederich
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Leukemia : CK(1005) : AC(398)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Heat Shock Protein Inducer : CK(83) : AC(30), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)
Additional Keywords : Heat Shock Protein Inducer : CK(5) : AC(4)

Curcumin exhibits anti-rheumatoid activity.

Pubmed Data : Eur J Pharmacol. 2009 Jun 10;612(1-3):161-6. Epub 2009 Apr 14. PMID: 19371737
Article Published Date : Jun 10, 2009
Authors : Viera Jancinová, Tomás Perecko, Radomír Nosál, Daniela Kostálová, Katarína Bauerová, Katarína Drábiková
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Arthritis: Rheumatoid : CK(307) : AC(55)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin exhibits gut-mediated anti-inflammatory/anti-arthritic activity.

Pubmed Data : Pharmacol Res. 2015 Mar 30. Epub 2015 Mar 30. PMID: 25836921
Article Published Date : Mar 29, 2015
Authors : Yan Yang, Xin Wu, Zhifeng Wei, Yannong Dou, Di Zhao, Ting Wang, Difei Bian, Bei Tong, Ying Xia, Yufeng Xia, Yue Dai
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Arthritis : CK(1964) : AC(312)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin has a great potential to treat psoriasis from these results.

Pubmed Data : Biochimie. 2016 Jan 27. Epub 2016 Jan 27. PMID: 26826458
Article Published Date : Jan 26, 2016
Authors : Di Kang, Bowen Li, Lei Luo, Wenbing Jiang, Qiumin Lu, Mingqing Rong, Ren Lai
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Psoriasis : CK(352) : AC(65)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin has a potential anti-inflammatory action against aluminum exposure.

Pubmed Data : Neurochem Res. 2012 Mar ;37(3):639-46. Epub 2011 Dec 1. PMID: 22130689
Article Published Date : Feb 29, 2012
Authors : Pooja Khanna Sood, Uma Nahar, Bimla Nehru
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Aluminum Toxicity : CK(207) : AC(75), Brain Inflammation : CK(274) : AC(145)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Neuroprotective Agents : CK(2360) : AC(1099), NF-kappaB Inhibitor : CK(1114) : AC(694), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)
Problem Substances : Aluminum : CK(274) : AC(78)

Curcumin has a preventive effect on experimental acute pancreatitis in mouse.

Pubmed Data : Indian J Med Res. 2011 Nov ;134(5):717-24. PMID: 22199113
Article Published Date : Nov 01, 2011
Authors : Wen-Guang Yu, Gang Xu, Gui-Jie Ren, Xia Xu, Hui-Qing Yuan, Xiao-Li Qi, Ke-Li Tian
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Pancreatitis : CK(217) : AC(56)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin has a profound anti-inflammatory therapeutic potential in the treatment of spinal cord injury.

Pubmed Data : Int J Mol Sci. 2016 ;17(1). Epub 2015 Dec 31. PMID: 26729105
Article Published Date : Dec 31, 2015
Authors : Lucia Machova Urdzikova, Kristyna Karova, Jiri Ruzicka, Anna Kloudova, Craig Shannon, Jana Dubisova, Raj Murali, Sarka Kubinova, Eva Sykova, Meena Jhanwar-Uniyal, Pavla Jendelova
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Spinal Cord Injuries : CK(139) : AC(46)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-2 Downregulation : CK(4) : AC(3), NF-kappaB Inhibitor : CK(1114) : AC(694)

Curcumin has a protective effect on experimentally induced inflammation, hepatotoxicity and cardiotoxicity in rats.

Pubmed Data : Exp Toxicol Pathol. 2010 Apr 2. Epub 2010 Apr 2. PMID: 20363603
Article Published Date : Apr 02, 2010
Authors : Suresh R Naik, Vishnu N Thakare, Snehal R Patil
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Cardiovascular Diseases : CK(7342) : AC(916), Inflammation : CK(3240) : AC(882), Liver Damage: Drug-Induced : CK(95) : AC(27)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Cardioprotective : CK(1596) : AC(409), Hepatoprotective : CK(1387) : AC(594)

Curcumin has an anti-allergic effect through modulating mast cell-mediated allergic responses in allergic rhinitis.

Pubmed Data : Cell Immunol. 2015 Nov-Dec;298(1-2):88-95. Epub 2015 Sep 28. PMID: 26507910
Article Published Date : Oct 31, 2015
Authors : Ning Zhang, Hong Li, Jihui Jia, Mingqiang He
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Allergic Rhinitis : CK(392) : AC(52), Allergies : CK(703) : AC(132)
Pharmacological Actions : Anti-Allergic Agents : CK(167) : AC(61), Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin has anti-inflammatory properties in patients with postoperative inflammation.

Pubmed Data : Int J Clin Pharmacol Ther Toxicol. 1986 Dec;24(12):651-4. PMID: 3546166
Article Published Date : Dec 01, 1986
Authors : R R Satoskar, S J Shah, S G Shenoy
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Inflammation : CK(3240) : AC(882), Postoperative Recovery : CK(197) : AC(19)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin has been evidence it possess both antimalarial activity and endothelial protection in vitro.

Pubmed Data : EXCLI J. 2014 ;13:287-99. Epub 2014 Mar 20. PMID: 26417261
Article Published Date : Dec 31, 2013
Authors : Sarun Kunwittaya, Lertyot Treeratanapiboon, Apapan Srisarin, Chartchalerm Isarankura-Na-Ayudhya, Virapong Prachayasittikul
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Malaria : CK(145) : AC(58)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Immunomodulatory : CK(1287) : AC(358)

Curcumin has multiple molecular mechanisms as a chemopreventive.

Pubmed Data : AAPS J. 2006;8(3):E443-9. Epub 2006 Jul 7. PMID: 17025261
Article Published Date : Jan 01, 2006
Authors : Rajesh L Thangapazham, Anuj Sharma, Radha K Maheshwari
Study Type : Review
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Anticarcinogenic Agents : CK(1099) : AC(519), Chemopreventive : CK(2835) : AC(787), NF-kappaB Inhibitor : CK(1114) : AC(694)

Curcumin has therapeutic value in inflammatory bowel disease.

Pubmed Data : Inflamm Bowel Dis. 2011 Feb;17(2):503-15. PMID: 20629184
Article Published Date : Feb 01, 2011
Authors : C B Larmonier, M T Midura-Kiela, R Ramalingam, D Laubitz, N Janikashvili, N Larmonier, F K Ghishan, P R Kiela
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Inflammatory Bowel Diseases : CK(1052) : AC(197)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin has value as an add=on therapy in patients with bronchial asthma.

Pubmed Data : J Clin Diagn Res. 2014 Aug ;8(8):HC19-24. Epub 2014 Aug 20. PMID: 25302215
Article Published Date : Jul 31, 2014
Authors : Afroz Abidi, Surabhi Gupta, Manu Agarwal, H L Bhalla, Mahip Saluja
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Bronchial Asthma : CK(1265) : AC(194)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin improves bone microarchitecture and enhances mineral density in transgenic mice.

Pubmed Data : Phytomedicine. 2011 Jan 15;18(2-3):205-13. Epub 2010 Jul 16. PMID: 20637579
Article Published Date : Jan 15, 2011
Authors : Mao-Wei Yang, Tong-Hao Wang, Pei-Pei Yan, Li-Wei Chu, Jiang Yu, Zhi-Da Gao, Yuan-Zhou Li, Bao-Lei Guo
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Bone Fractures : CK(514) : AC(78), Osteopenia : CK(229) : AC(41), Osteoporosis : CK(1283) : AC(245)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin improves ulcerative proctitis and Crohn's disease in patient s with inflammatory bowel disease.

Pubmed Data : Dig Dis Sci. 2005 Nov;50(11):2191-3. PMID: 16240238
Article Published Date : Nov 01, 2005
Authors : Peter R Holt, Seymour Katz, Robert Kirshoff
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Inflammatory Bowel Diseases : CK(1052) : AC(197), Proctitis : CK(10) : AC(1), Proctocolitis: Ulcerative : CK(30) : AC(3)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin induces programmed cell death and inhibits proinflammatory prostaglandin E2 production in synovial fibroblasts of patients with rheumatoid arthritis.

Pubmed Data : Int J Mol Med. 2007 Sep;20(3):365-72. PMID: 17671742
Article Published Date : Sep 01, 2007
Authors : Cheol Park, Dong-Oh Moon, Il-Whan Choi, Byung Tae Choi, Taek-Jeong Nam, Chung-Ho Rhu, Taeg Kyu Kwon, Won Ho Lee, Gi-Young Kim, Yung Hyun Choi
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Arthritis: Rheumatoid : CK(307) : AC(55), Rheumatoid Arthritis : CK(706) : AC(117)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin inhibits experimental collitis via anti-angiogenic and anti-inflammatory properties.

Pubmed Data : J Pharm Pharmacol. 2009 Mar;61(3):311-21. PMID: 19222903
Article Published Date : Mar 01, 2009
Authors : Vivek Ramshankar Yadav, Sarasija Suresh, Kshama Devi, Seema Yadav
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Colitis : CK(255) : AC(111)
Pharmacological Actions : Anti-Angiogenic : CK(197) : AC(137), Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin inhibits gonorrhoeae-induced NF-kappaB signaling, release of pro-inflammatory cytokines/chemokines and attenuates adhesion in late infection.

Pubmed Data : Biol Chem. 2005 May;386(5):481-90. PMID: 15927892
Article Published Date : May 01, 2005
Authors : Silja Wessler, Petra Muenzner, Thomas F Meyer, Michael Naumann
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Gonorrhea : CK(5) : AC(4)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), NF-kappaB Inhibitor : CK(1114) : AC(694)

Curcumin inhibits HMGB1 releasing and attenuates concanavalin A-induced hepatitis in mice.

Pubmed Data : Eur J Pharmacol. 2012 Oct 11. Epub 2012 Oct 11. PMID: 23063543
Article Published Date : Oct 10, 2012
Authors : Chao Wang, Hao Nie, Kan Li, Yan-Xiang Zhang, Fei Yang, Cheng-Bin Li, Chang-Fu Wang, Quan Gong
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Hepatitis: Lectin-Induced (concanavalin) : CK(8) : AC(4)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Hepatoprotective : CK(1387) : AC(594), High-mobility group box-1 (HMGB1) inhibitor : CK(2) : AC(1)

Curcumin inhibits inflammation associated with secretion of inflammatory chemokines.

Pubmed Data : Food Chem Toxicol. 2010 Jan;48(1):47-52. Epub 2009 Sep 18. PMID: 19766691
Article Published Date : Jan 01, 2010
Authors : Jun Hee Lim, Taeg Kyu Kwon
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Inflammation : CK(3240) : AC(882)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antineoplastic Agents : CK(1158) : AC(639), NF-kappaB Inhibitor : CK(1114) : AC(694)

Curcumin inhibits lipopolysaccharide-induced inflammation.

Pubmed Data : Int Immunopharmacol. 2010 Jul;10(7):760-8. Epub 2010 Apr 22. PMID: 20399909
Article Published Date : Jul 01, 2010
Authors : In Duk Jung, Young-Il Jeong, Chang-Min Lee, Kyung Tae Noh, Soo Kyung Jeong, Sung Hak Chun, Oksoon Hong Choi, Won Sun Park, Jin Han, Yong Kyoo Shin, Han Wool Kim, Cheol-Heui Yun, Yeong-Min Park
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Inflammation : CK(3240) : AC(882), Lipopolysaccharide-Induced Toxicity : CK(380) : AC(218)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Cyclooxygenase 2 Inhibitors : CK(464) : AC(272), Prostaglandin PGE2 downregulation : CK(96) : AC(46)

Curcumin inhibits lipoxygenase, indicating it possesses anti-inflammatory and anti-cancer properties.

Pubmed Data : Int J Mol Med. 2000 Nov;6(5):521-6. PMID: 11029517
Article Published Date : Nov 01, 2000
Authors : E Skrzypczak-Jankun, N P McCabe, S H Selman, J Jankun
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Inflammation : CK(3240) : AC(882)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Chemopreventive : CK(2835) : AC(787), Enzyme Inhibitors : CK(473) : AC(251), Lipoxygenase Inhibitors : CK(38) : AC(17)

Curcumin inhibits the growth of breast cancer through the manipulation of the arachidonate metabolism.

Pubmed Data : BMC Cancer. 2007;7:138. Epub 2007 Jul 25. PMID: 17651499
Article Published Date : Jan 01, 2007
Authors : Rasha Hammamieh, Dena Sumaida, XiaoYan Zhang, Rina Das, Marti Jett
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Breast Cancer : CK(3592) : AC(1064), Cancers: Drug Resistant : CK(352) : AC(223)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Cyclooxygenase Inhibitors : CK(71) : AC(39), Lipoxygenase Inhibitors : CK(38) : AC(17)
Additional Keywords : Drug: Doxorubicin : CK(166) : AC(62)

Curcumin intake has some beneficial effects on the recovery of eccentric exercise induced muscle damage.

Pubmed Data : Eur J Appl Physiol. 2015 Sep ;115(9):1949-57. Epub 2015 Apr 29. PMID: 25921600
Article Published Date : Aug 31, 2015
Authors : Yoko Tanabe, Seiji Maeda, Nobuhiko Akazawa, Asako Zempo-Miyaki, Youngju Choi, Song-Gyu Ra, Atsushi Imaizumi, Yoshihiko Otsuka, Kazunori Nosaka
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Muscle Damage: Exercise-Induced : CK(155) : AC(22)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin is effective in attenuating glial activation and ameliorates cognitive deficits in chronic epilepsy.

Pubmed Data : Neurochem Int. 2015 Jul 16. Epub 2015 Jul 16. PMID: 26190183
Article Published Date : Jul 15, 2015
Authors : Harpreet Kaur, Ishan Patro, Kulbhushan Tikoo, Rajat Sandhir
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Brain Inflammation : CK(274) : AC(145), Cognitive Decline/Dysfunction : CK(1163) : AC(215), Epilepsy : CK(255) : AC(66)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin may be a promising pharmacological candidate for neurodegenerative diseases.

Pubmed Data : PLoS One. 2016 ;11(1):e0147721. Epub 2016 Jan 29. PMID: 26824354
Article Published Date : Dec 31, 2015
Authors : Gen-Lin He, Zhen Luo, Ju Yang, Ting-Ting Shen, Yi Chen, Xue-Sen Yang
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Alzheimer's Disease : CK(1292) : AC(382), Neurodegenerative Diseases : CK(3376) : AC(850)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Prostaglandin PGE2 downregulation : CK(96) : AC(46)

Curcumin may be effective against oxidative bowel damages induced in IBD by imbalanced gut immune response.

Pubmed Data : Int Immunopharmacol. 2012 Jan ;12(1):302-11. Epub 2011 Oct 29. PMID: 22036766
Article Published Date : Jan 01, 2012
Authors : Souad Mouzaoui, Ibtissem Rahim, Bahia Djerdjouri
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Colitis : CK(255) : AC(111), Crohn's Disease : CK(153) : AC(30), Inflammatory Bowel Diseases : CK(1052) : AC(197)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin may have a direct suppressive effect on intestinal mast cell activation and reverse food allergy symptoms in allergen-sensitized individuals.

Pubmed Data : PLoS One. 2015;10(7):e0132467. Epub 2015 Jul 6. PMID: 26147007
Article Published Date : Dec 31, 2014
Authors : Shannon R M Kinney, Logan Carlson, Jennifer Ser-Dolansky, Chelsea Thompson, Sagar Shah, Amos Gambrah, Wei Xing, Sallie S Schneider, Clinton B Mathias
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Anaphylaxis : CK(67) : AC(18), Food Allergies : CK(507) : AC(70), Mastocytosis : CK(2) : AC(1)
Pharmacological Actions : Anti-Allergic Agents : CK(167) : AC(61), Anti-Inflammatory Agents : CK(4861) : AC(1630), NF-kappaB Inhibitor : CK(1114) : AC(694)
Additional Keywords : Significant Treatment Outcome : CK(3038) : AC(366)

Curcumin may have therapeutic value in inflammatory conditions of the central nervous system.

Pubmed Data : J Neuroinflammation. 2005 Feb 25;2(1):8. Epub 2005 Feb 25. PMID: 15733321
Article Published Date : Feb 25, 2005
Authors : Michiyo Tomita, Brita J Holman, Christopher P Santoro, Thomas J Santoro
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Brain Inflammation : CK(274) : AC(145)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin may offer protective effects against methotrexate-induced rat enteritis by lowering the intestinal mucosal permeability.

Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2008 Jan;28(1):119-21. PMID: 18227041
Article Published Date : Jan 01, 2008
Authors : Wei-Bing Song, Zhen-Shu Zhang, Bing Xiao
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Drug Toxicity: Methotrexate : CK(39) : AC(18), Gastroenteritis : CK(107) : AC(15), Intestinal Permeability : CK(245) : AC(60)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin may protect against amyloid-beta-stimulated inflammation associated wtih Alzheimer disease.

Pubmed Data : J Alzheimers Dis. 2010;20(4):1189-99. PMID: 20413894
Article Published Date : Jan 01, 2010
Authors : Hong-Mei Wang, Yan-Xin Zhao, Shi Zhang, Gui-Dong Liu, Wen-Yan Kang, Hui-Dong Tang, Jian-Qing Ding, Sheng-Di Chen
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Alzheimer's Disease : CK(1292) : AC(382), Brain Inflammation : CK(274) : AC(145), Inflammation : CK(3240) : AC(882)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Cyclooxygenase 2 Inhibitors : CK(464) : AC(272), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin may reduce inflammation in the pancreas.

Pubmed Data : Mol Biol Rep. 2009 Nov;36(8):2329-32. Epub 2009 Jan 21. PMID: 19156536
Article Published Date : Nov 01, 2009
Authors : Keynoosh Khalooghi, Saeid Hashemi, Nahid Mehraban, Parvin Amiri, Javad Tavakkoly Bazzaz, Bagher Larijani, Mahsa M Amoli
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Lipopolysaccharide-Induced Toxicity : CK(380) : AC(218), Pancreatitis : CK(217) : AC(56)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin may represent a novel therapeutic agent targeting endothelial activation in inflammatory bowel disease.

Pubmed Data : Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G259-68. Epub 2009 Jun 11. PMID: 19520742
Article Published Date : Aug 01, 2009
Authors : David G Binion, Jan Heidemann, Mona S Li, Victoria M Nelson, Mary F Otterson, Parvaneh Rafiee
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Inflammatory Bowel Diseases : CK(1052) : AC(197), Lipopolysaccharide-Induced Toxicity : CK(380) : AC(218)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669), Vascular Cell Adhesion Molecule-1 Inhibitor : CK(117) : AC(30)

Curcumin may stimulate recovery from spinal cord injury.

Pubmed Data : J Neurosurg Spine. 2012 Feb 10. Epub 2012 Feb 10. PMID: 22324804
Article Published Date : Feb 10, 2012
Authors : D Ryan Ormond, Hong Peng, Richard Zeman, Kaushik Das, Raj Murali, Meena Jhanwar-Uniyal
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Spinal Cord Injuries : CK(139) : AC(46)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)
Additional Keywords : Regenerative Substances : CK(42) : AC(19)

Curcumin modulates the immune response associated with LPS-induced periodontal disease in rats, indicating its potential therapeutic value.

Pubmed Data : Innate Immun. 2011 Jan 17. Epub 2011 Jan 17. PMID: 21242275
Article Published Date : Jan 17, 2011
Authors : Morgana Rodrigues Guimarães, Sabrina Garcia de Aquino, Leila S Coimbra, Luis Carlos Spolidorio, Keith L Kirkwood, Carlos Rossa
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Lipopolysaccharide-Induced Toxicity : CK(380) : AC(218), Periodontal Diseases : CK(257) : AC(64)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin mouthwash is well tolerated and effective in controlling the signs and symptoms of Radio-chemotherapy induced oral mucositis.

Pubmed Data : J Clin Diagn Res. 2015 Aug ;9(8):ZC59-62. Epub 2015 Aug 1. PMID: 26436049
Article Published Date : Jul 31, 2015
Authors : Karthikeya Patil, Mahima V Guledgud, P K Kulkarni, Deepika Keshari, Srishti Tayal
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Radiation Induced Illness: Mucositis : CK(28) : AC(6), Wound Healing : CK(539) : AC(161)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)
Additional Keywords : Chemical: Chlorhexidine : CK(10) : AC(1), Natural Substances Versus Chemicals : CK(51) : AC(6), Significant Treatment Outcome : CK(3038) : AC(366)

Curcumin potentially modulates activation of dendritic cells and promotes the recovery of damaged colonic mucosa in IBD.

Pubmed Data : World J Gastroenterol. 2016 Jun 21 ;22(23):5374-83. PMID: 27340353
Article Published Date : Jun 20, 2016
Authors : Hai-Mei Zhao, Rong Xu, Xiao-Ying Huang, Shao-Min Cheng, Min-Fang Huang, Hai-Yang Yue, Xin Wang, Yong Zou, Ai-Ping Lu, Duan-Yong Liu
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Colitis : CK(255) : AC(111), Inflammatory Bowel Diseases : CK(1052) : AC(197)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin potently inhibits the activation of NLRP3 inflammasome which may contribute to its anti-inflammatory activity.

Pubmed Data : Mol Nutr Food Res. 2015 Aug 7. Epub 2015 Aug 7. PMID: 26250869
Article Published Date : Aug 06, 2015
Authors : Zizhen Gong, Jiefei Zhou, Hui Li, Yanhong Gao, Congfeng Xu, Shengnan Zhao, Yingwei Chen, Wei Cai, Jin Wu
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Inflammation : CK(3240) : AC(882), Lipopolysaccharide-Induced Toxicity : CK(380) : AC(218)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-1 beta downregulation : CK(478) : AC(205)

Curcumin prevents chemically-induced colitis.

Pubmed Data : Scand J Gastroenterol. 2009;44(2):187-94. PMID: 18830899
Article Published Date : Jan 01, 2009
Authors : Asmaa S Lubbad, Mabayoje A Oriowo, Islam Khan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Colitis : CK(255) : AC(111)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), NF-kappaB Inhibitor : CK(1114) : AC(694)

Curcumin protects against MSG-induced neurotoxicity in rats.

Pubmed Data : Neurosignals. 2016 Aug 17 ;24(1):81-87. Epub 2016 Aug 17. PMID: 27529496
Article Published Date : Aug 16, 2016
Authors : Rania M Khalil, Naglaa F Khedr
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : MSG Toxicity : CK(12) : AC(6)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Neuroprotective Agents : CK(2360) : AC(1099), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)
Problem Substances : Monosodium Glutamate (MSG) : CK(104) : AC(34)

Curcumin protects dopaminergic neuron against lipopolysaccharide induced neurotoxicity.

Pubmed Data : Neurochem Res. 2008 Oct;33(10):2044-53. Epub 2008 Mar 27. PMID: 18368483
Article Published Date : Oct 01, 2008
Authors : Sufen Yang, Dan Zhang, Zhengqin Yang, Xiaoming Hu, Steven Qian, Jie Liu, Belinda Wilson, Michelle Block, Jau-Shyong Hong
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Brain: Microglial Activation : CK(82) : AC(53), Lipopolysaccharide-Induced Toxicity : CK(380) : AC(218), Neurodegenerative Diseases : CK(3376) : AC(850)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-1 beta downregulation : CK(478) : AC(205), Neuroprotective Agents : CK(2360) : AC(1099), NF-kappaB Inhibitor : CK(1114) : AC(694), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin protects effects against cerebral I/R injury through the activation of JAK2/STAT3 signaling pathway.

Pubmed Data : Int J Clin Exp Med. 2015;8(9):14985-14991. Epub 2015 Sep 15. PMID: 26628981
Article Published Date : Dec 31, 2014
Authors : Linlin Li, Haiyong Li, Mingming Li
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Cerebral Ischemia : CK(229) : AC(77)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-1 beta downregulation : CK(478) : AC(205), Interleukin-8 downregulation : CK(166) : AC(61), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects mice from P. acnes-induced liver injury through reduction of HMGB1 cytoplasmic translocation and expression.

Pubmed Data : Int Immunopharmacol. 2015 Feb ;24(2):159-65. Epub 2014 Dec 13. PMID: 25510585
Article Published Date : Jan 31, 2015
Authors : Qiaoli Gu, Honggeng Guan, Qin Shi, Yanyun Zhang, Huilin Yang
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Acne : CK(327) : AC(53), Gram-Negative Bacterial Infections : CK(46) : AC(33)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Hepatoprotective : CK(1387) : AC(594)

Curcumin reduces adjuvant-induced c-reactive protein and inflammation.

Pubmed Data : Immunopharmacol Immunotoxicol. 2003 May;25(2):213-24. PMID: 12784914
Article Published Date : May 01, 2003
Authors : Manish Banerjee, L M Tripathi, V M L Srivastava, Anju Puri, Rakesh Shukla
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : C-Reactive Protein : CK(1852) : AC(174), Inflammation : CK(3240) : AC(882)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin regulates the shift from Th1 to Th2 in trinitrobenzene sulphonic acid-induced chronic colitis.

Pubmed Data : Acta Pharmacol Sin. 2006 Aug;27(8):1071-7. PMID: 16867261
Article Published Date : Aug 01, 2006
Authors : Ming Zhang, Chang-Sheng Deng, Jia-Ju Zheng, Jian Xia
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Colitis : CK(255) : AC(111), Immune Dysregulation: TH1 dominance : CK(27) : AC(6)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Immunomodulatory : CK(1287) : AC(358), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin represents grounds for optimism in terms of anti-inflammatory treatment in acute otitis media.

Pubmed Data : J Craniofac Surg. 2016 Jul 1. Epub 2016 Jul 1. PMID: 27380582
Article Published Date : Jun 30, 2016
Authors : Servet Akyuz, Fatih Turan, Levent Gurbuzler, Akgül Arici, Erkan Sogut, Ozalkan Ozkan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Otitis media : CK(305) : AC(41)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Malondialdehyde Down-regulation : CK(554) : AC(152)

Curcumin significantly inhibited the production of pro-inflammatory cytokine IL-18 in E.coli LPS stimulated murine macrophage-like cells.

Pubmed Data : Indian J Clin Biochem. 2015 Jan ;30(1):109-12. Epub 2014 Jul 15. PMID: 25646051
Article Published Date : Dec 31, 2014
Authors : Renu Yadav, Babban Jee, Sudhir Kumar Awasthi
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Inflammation : CK(3240) : AC(882)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-18 down-regulation : CK(20) : AC(7)
Additional Keywords : Dose Response : CK(1056) : AC(408)

Curcumin significantly reduced inflammatory responses and pathological changes in lung tissue exposed to paraquat.

Pubmed Data : Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2015 Sep ;33(9):689-92. PMID: 26832707
Article Published Date : Aug 31, 2015
Authors : Hongjun Li, Baonan Liu, Peng Li, Lingji Feng, Haihong Ma, Shimeng Xuan, Yongzhi Cao
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Herbicide Toxicity : CK(12) : AC(7)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin supplementation significantly decreases serum concentrations of pro-inflammatory cytokines in subjects with MetS.

Pubmed Data : Biomed Pharmacother. 2016 Jun 6 ;82:578-582. Epub 2016 Jun 6. PMID: 27470399
Article Published Date : Jun 05, 2016
Authors : Yunes Panahi, Mahboobeh Sadat Hosseini, Nahid Khalili, Effat Naimi, Luis E Simental-Mendía, Muhammed Majeed, Amirhossein Sahebkar
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Metabolic Diseases : CK(411) : AC(75), Metabolic Syndrome X : CK(916) : AC(158)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-6 Downregulation : CK(1137) : AC(354), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin suppresses ERK1/2 and p38 signaling, thus, attenuating inflammatory responses of brain microglia.

Pubmed Data : Neurosci Lett. 2015 May 6 ;594:105-10. Epub 2015 Mar 25. PMID: 25818332
Article Published Date : May 05, 2015
Authors : Xiaolei Shi, Zhenyang Zheng, Jie Li, Zijian Xiao, Weiwei Qi, Aiwu Zhang, Qi Wu, Yannan Fang
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Alzheimer's Disease : CK(1292) : AC(382)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-1 beta downregulation : CK(478) : AC(205), Interleukin-6 Downregulation : CK(1137) : AC(354), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)
Additional Keywords : Dose Response : CK(1056) : AC(408)

Curcumin suppresses gastric NF-kappaB activation and macromolecular leakage in Helicobacter pylori-infected rats.

Pubmed Data : World J Gastroenterol. 2010 Aug 28;16(32):4039-46. PMID: 20731017
Article Published Date : Aug 28, 2010
Authors : Kawiya Sintara, Duangporn Thong-Ngam, Suthiluk Patumraj, Naruemon Klaikeaw, Tanittha Chatsuwan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Helicobacter Pylori Infection : CK(506) : AC(104)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), NF-kappaB Inhibitor : CK(1114) : AC(694)

Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression associated with inflammation.

Pubmed Data : J Pharmacol Sci. 2004 Mar;94(3):325-8. PMID: 15037818
Article Published Date : Mar 01, 2004
Authors : Gu Kang, Pil-Jae Kong, Young-Jin Yuh, So-Young Lim, Sung-Vin Yim, Wanjoo Chun, Sung-Soo Kim
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Brain: Microglial Activation : CK(82) : AC(53), Lipopolysaccharide-Induced Toxicity : CK(380) : AC(218)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Cyclooxygenase 2 Inhibitors : CK(464) : AC(272), NF-kappaB Inhibitor : CK(1114) : AC(694)

Curcumin suppresses the inflammatory response of brain microglial cells.

Pubmed Data : J Immunol. 2003 Dec 1;171(11):6072-9. PMID: 14634121
Article Published Date : Dec 01, 2003
Authors : Hee Young Kim, Eun Jung Park, Eun-Hye Joe, Ilo Jou
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Brain: Microglial Activation : CK(82) : AC(53), Inflammation : CK(3240) : AC(882)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Cyclooxygenase 2 Inhibitors : CK(464) : AC(272)

Curcumin suppresses type II collagen-induced arthritis in mice.

Pubmed Data : J Pharmacol Sci. 2009 Sep;111(1):13-21. PMID: 19763044
Article Published Date : Sep 01, 2009
Authors : Se Hwan Mun, Hyuk Soon Kim, Jie Wan Kim, Na Young Ko, Do Kyun Kim, Beob Yi Lee, Bokyung Kim, Hyung Sik Won, Hwa-Sup Shin, Jeung-Whan Han, Hoi Young Lee, Young Mi Kim, Wahn Soo Choi
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Arthritis : CK(1964) : AC(312), Rheumatoid Arthritis : CK(706) : AC(117)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Matrix metalloproteinase-1 (MMP-1) inhibitor : CK(32) : AC(16), Matrix metalloproteinase-3 (MMP-3) inhibitor : CK(61) : AC(18)

Curcumin suppression of cytokine release and cytokine storm. A potential therapy for patients with Ebola and other severe viral infections.

Pubmed Data : In Vivo. 2015 Jan-Feb;29(1):1-4. PMID: 25600522
Article Published Date : Dec 31, 2014
Authors : Peter P Sordillo, Lawrence Helson
Study Type : Review
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Ebola : CK(1) : AC(1)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)
Additional Keywords : Cytokine Modulation : CK(17) : AC(6), Cytokine Storm : CK(5) : AC(2)

Curcumin treatment attenuates liver lesions induced by intestinal ischemia/reperfusion.

Pubmed Data : Oxid Med Cell Longev. 2014 ;2014:191624. Epub 2014 Aug 20. PMID: 25215173
Article Published Date : Dec 31, 2013
Authors : Zhe Fan, Huirong Jing, Jihong Yao, Yang Li, Xiaowei Hu, Huizhu Shao, Gang Shen, Jiyong Pan, Fuwen Luo, Xiaofeng Tian
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Intestinal Ischemia : CK(12) : AC(6), Liver Damage : CK(877) : AC(329)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Hepatoprotective : CK(1387) : AC(594), Interleukin-6 Downregulation : CK(1137) : AC(354), NF-kappaB Inhibitor : CK(1114) : AC(694), Superoxide Dismutase Up-regulation : CK(530) : AC(174)

Curcumin was demonstrated to be effective as an adjuvant therapy for the treatment of psoriasis vulgaris and to significantly reduce serum levels of IL-22.

Pubmed Data : Biomed Res Int. 2015 ;2015:283634. Epub 2015 May 18. PMID: 26090395
Article Published Date : Dec 31, 2014
Authors : Emiliano Antiga, Veronica Bonciolini, Walter Volpi, Elena Del Bianco, Marzia Caproni
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Psoriasis : CK(352) : AC(65)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Immunomodulatory : CK(1287) : AC(358), Interleukin-22 Downregulation : CK(10) : AC(1)

Curcumin was effective in restoring the histopathological changes induced by acetic acid administration.

Pubmed Data : J Environ Pathol Toxicol Oncol. 2015;34(4):309-320. PMID: 26756424
Article Published Date : Dec 31, 2014
Authors : Boobalan Gopu, Rasakatla Dileep, Matukumalli Usha Rani, C S V Satish Kumar, Matham Vijay Kumar, Alla Gopala Reddy
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Inflammatory Bowel Diseases : CK(1052) : AC(197)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-1 beta downregulation : CK(478) : AC(205), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1905) : AC(215)

Curcumin's anti-inflammatory properties are related to its ability to inhibit the neutrophil response.

Pubmed Data : Agents Actions. 1989 Nov;28(3-4):298-303. PMID: 2556903
Article Published Date : Nov 01, 1989
Authors : R Srivastava
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Inflammation : CK(3240) : AC(882)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin, berberine chloride and epigallocatechin gallate could be potential alternatives for prednisolone in inflammation.

Pubmed Data : PLoS One. 2016 ;11(5):e0155325. Epub 2016 May 10. PMID: 27163931
Article Published Date : Dec 31, 2015
Authors : Iris E Allijn, Stefan F C Vaessen, Linda C Quarles van Ufford, Kees J Beukelman, Menno P J de Winther, Gert Storm, Raymond M Schiffelers
Study Type : In Vitro Study
Additional Links
Substances : Berberine : CK(325) : AC(166), Curcumin : CK(4803) : AC(2175), EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Inflammation : CK(3240) : AC(882)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-6 Downregulation : CK(1137) : AC(354), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)
Additional Keywords : Natural Substances Versus Drugs : CK(1698) : AC(302)
Problem Substances : Prednisolone : CK(3) : AC(1)

Curcumin, capsaicin and piperine have anti-inflammatory effects on H. pylori-induced gastritis in gerbils and may have potential chemoprevention of H. pylori-associated gastric carcinogenesis.

Pubmed Data : Helicobacter. 2015 Jul 3. Epub 2015 Jul 3. PMID: 26140520
Article Published Date : Jul 02, 2015
Authors : Takeshi Toyoda, Liang Shi, Shinji Takasu, Young-Man Cho, Yuka Kiriyama, Akiyoshi Nishikawa, Kumiko Ogawa, Masae Tatematsu, Tetsuya Tsukamoto
Study Type : Animal Study
Additional Links
Substances : Capsaicin : CK(129) : AC(55), Curcumin : CK(4803) : AC(2175), Piperine : CK(114) : AC(60)
Diseases : Gastritis : CK(51) : AC(10), Helicobacter Pylori Infection : CK(506) : AC(104)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Anticarcinogenic Agents : CK(1099) : AC(519), Chemopreventive : CK(2835) : AC(787)

Curcumin, EGCG and resveratrol inhibit inflammation.

Pubmed Data : Mutat Res. 2001 Sep 1;480-481:243-68. PMID: 11506818
Article Published Date : Sep 01, 2001
Authors : Y J Surh, K S Chun, H H Cha, S S Han, Y S Keum, K K Park, S S Lee
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), EGCG (Epigallocatechin gallate) : CK(1956) : AC(314), Resveratrol : CK(1283) : AC(746)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Anticarcinogenic Agents : CK(1099) : AC(519), Cyclooxygenase 1 Inhibitor : CK(34) : AC(27), Cyclooxygenase 2 Inhibitors : CK(464) : AC(272), NF-kappaB Inhibitor : CK(1114) : AC(694)

Curcumin, resveratrol and flavonoids act as anti-inflammatory, cyto- and DNA-protective dietary compounds.

Pubmed Data : Toxicology. 2009 Nov 10. Epub 2009 Nov 10. PMID: 19903510
Article Published Date : Nov 10, 2009
Authors : Kavita Bisht, Karl-Heinz Wagner, Andrew C Bulmer
Study Type : Commentary
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Flavonoids : CK(1215) : AC(379), Resveratrol : CK(1283) : AC(746)
Diseases : DNA damage : CK(1017) : AC(387)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Curcumin, when used as a complementary treatment to albendazole, could help to alleviate eosinophilic meningitis through suppression of eosinophil count in the cerebrospinal fluid.

Pubmed Data : Parasitology. 2012 Mar ;139(3):358-65. Epub 2011 Nov 7. PMID: 22053741
Article Published Date : Feb 29, 2012
Authors : Ling-Yuh Shyu, Han-Hsin Chang, Jeng-Dong Hsu, David Pei-Cheng Lin, Ying-Hock Teng, Hsiu-Hsiung Lee
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Angiostrongylus Cantonensis Infection : CK(4) : AC(2), Eosinophilic Meningitis : CK(4) : AC(2)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(287) : AC(147)

Curcumin-loaded lipid nanoemulsions have therapeutic applications in different inflammatory pathologies localized in the liver or the lungs.

Pubmed Data : J Pharm Pharmacol. 2016 Jan 8. Epub 2016 Jan 8. PMID: 26748549
Article Published Date : Jan 07, 2016
Authors : Viorel Simion, Daniela Stan, Cristina Ana Constantinescu, Mariana Deleanu, Emanuel Dragan, Monica Madalina Tucureanu, Ana-Maria Gan, Elena Butoi, Alina Constantin, Ileana Manduteanu, Maya Simionescu, Manuela Calin
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Inflammation : CK(3240) : AC(882)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)
Additional Keywords : Nanoencapsulated Curcumin : CK(3) : AC(2)

Curcuminoids represent an effective and safe alternative treatment for OA.

Pubmed Data : Phytother Res. 2014 Nov ;28(11):1625-31. Epub 2014 May 22. PMID: 24853120
Article Published Date : Oct 31, 2014
Authors : Yunes Panahi, Ali-Reza Rahimnia, Mojtaba Sharafi, Gholamhossein Alishiri, Amin Saburi, Amirhossein Sahebkar
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Osteoarthritis: Knee : CK(517) : AC(53)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)
Additional Keywords : Phytotherapy : CK(1216) : AC(221)

Current data suggest that curcumin undergoes degradation due to roasting and its degradation product exhibit significant biological activity in cultured cells.

Pubmed Data : Food Funct. 2015 Mar 11 ;6(3):887-93. PMID: 25619943
Article Published Date : Mar 10, 2015
Authors : Tuba Esatbeyoglu, Katrin Ulbrich, Clemens Rehberg, Sascha Rohn, Gerald Rimbach
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Curcumin: Degradiation byproducts : CK(1) : AC(1)
Diseases : Inflammation : CK(3240) : AC(882)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-6 Downregulation : CK(1137) : AC(354)
Additional Keywords : Gene Expression : CK(93) : AC(46)

Curumin reduces inflammation associated with Angiostrongylus cantonensis-induced eosinophilic meningitis.

Pubmed Data : J Helminthol. 2007 Mar;81(1):1-5. PMID: 17381860
Article Published Date : Mar 01, 2007
Authors : P C Shih, H H Lee, S C Lai, K M Chen, S T Jiang, Y F Chen, S J Shiow
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Angiostrongylus Cantonensis Infection : CK(4) : AC(2), Eosinophilic Meningitis : CK(4) : AC(2)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses in microglia cells.

Pubmed Data : Int Immunopharmacol. 2010 Mar;10(3):331-8. Epub 2009 Dec 16. PMID: 20018257
Article Published Date : Mar 01, 2010
Authors : Lijia Zhang, Chunfu Wu, Siqi Zhao, Dan Yuan, Guoning Lian, Xiaoxiao Wang, Lihui Wang, Jingyu Yang
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Brain: Microglial Activation : CK(82) : AC(53), Inflammation : CK(3240) : AC(882), Lipopolysaccharide-Induced Toxicity : CK(380) : AC(218)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-1 beta downregulation : CK(478) : AC(205), NF-kappaB Inhibitor : CK(1114) : AC(694), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Diarylheptanoids of Curcuma comosa inhibited lipopolysaccharide induced nitric oxide production in macrophage RAW 264.7 cells

Pubmed Data : Nat Prod Commun. 2015 Jan ;10(1):89-93. PMID: 25920227
Article Published Date : Dec 31, 2014
Authors : Nilubon Sornkaewa, Yuan Lin, Fei Wang, Guolin Zhang, Ratchanaporn Chokchaisiri, Ailian Zhang, Kanjana Wongkrajang, Parichat Suebsakwong, Pawinee Piyachaturawat, Apichart Suksamrarn
Study Type : In Vitro Study
Additional Links
Substances : Turmeric : CK(5032) : AC(2348)
Diseases : Lipopolysaccharide-Induced Toxicity : CK(380) : AC(218)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Nitric Oxide Inhibitor : CK(223) : AC(108)

Dietary curcumin prevents colon carcinogenesis.

Pubmed Data : Cancer Res. 1995 Jan 15;55(2):259-66. PMID: 7812955
Article Published Date : Jan 15, 1995
Authors : C V Rao, A Rivenson, B Simi, B S Reddy
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Colon Cancer : CK(749) : AC(430)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Dietary supplementation of curcumin alleviates NF-κB-dependent skeletal muscle wasting in rats.

Pubmed Data : Endocr Metab Immune Disord Drug Targets. 2016 Jun 13. Epub 2016 Jun 13. PMID: 27297427
Article Published Date : Jun 12, 2016
Authors : Jun Hejun8067 163 Com He, Hongmei Xie, Shan Wu
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Cachexia : CK(77) : AC(25)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), NF-kappaB Inhibitor : CK(1114) : AC(694)

Ginger and turmeric rhizomes decreased the anti-inflammatory cytokines in hypertensive rats.

Pubmed Data : Planta Med. 2016 Mar 22. Epub 2016 Mar 22. PMID: 27002391
Article Published Date : Mar 21, 2016
Authors : Ayodele Jacob Akinyemi, Gustavo Roberto Thomé, Vera Maria Morsch, Nathieli B Bottari, Jucimara Baldissarelli, Lizielle Souza de Oliveira, Jeferson Ferraz Goularte, Adriane Belló-Klein, Thiago Duarte, Marta Duarte, Aline Augusti Boligon, Margareth Linde Athayde, Akintunde Afolabi Akindahunsi, Ganiyu Oboh, Maria Rosa Chitolina Schetinger
Study Type : Animal Study
Additional Links
Substances : Ginger : CK(696) : AC(184), Turmeric : CK(5032) : AC(2348)
Diseases : Hypertension : CK(2984) : AC(406), Inflammation : CK(3240) : AC(882)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-10 downregulation : CK(128) : AC(45), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Glutamine and arginine-fortified PF with curcumin might be a promising option to enhance the effectiveness and expand the scope of EEN therapy.

Pubmed Data : JPEN J Parenter Enteral Nutr. 2016 Jan 29. Epub 2016 Jan 29. PMID: 26826259
Article Published Date : Jan 28, 2016
Authors : Moftah H Alhagamhmad, Andrew S Day, Daniel A Lemberg, Steven T Leach
Study Type : In Vitro Study
Additional Links
Substances : Arginine : CK(1012) : AC(176), Curcumin : CK(4803) : AC(2175), Glutamine : CK(123) : AC(24), Vitamin D : CK(3681) : AC(511)
Diseases : Crohn's Disease : CK(153) : AC(30), Inflammatory Bowel Diseases : CK(1052) : AC(197)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-8 downregulation : CK(166) : AC(61)

HCA may be of therapeutic potential for atopic dermatitis as it acts by suppressing keratinocyte activation.

Pubmed Data : PLoS One. 2016 ;11(3):e0150952. Epub 2016 Mar 9. PMID: 26959360
Article Published Date : Dec 31, 2015
Authors : Hyun-Su Lee, Eun-Ju Choi, Kyung-Sik Lee, Hye-Ran Kim, Bo-Ra Na, Min-Sung Kwon, Gil-Saeng Jeong, Hyun Gyu Choi, Eun Young Choi, Chang-Duk Jun
Study Type : Animal Study
Additional Links
Substances : Turmeric : CK(5032) : AC(2348)
Diseases : Atopic Dermatitis : CK(1134) : AC(117)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Immunomodulatory : CK(1287) : AC(358)

Intranasal curcumin alleviate paraquat induced pulmonary damage and pro-inflammatory cytokine levels like tumor necrosis factor-α (TNF-α) and nitric oxide (NO).

Pubmed Data : Environ Toxicol Pharmacol. 2014 Nov ;38(3):913-21. Epub 2014 Oct 18. PMID: 25461551
Article Published Date : Oct 31, 2014
Authors : Namitosh Tyagi, Asha Kumari, D Dash, Rashmi Singh
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Herbicide Toxicity : CK(12) : AC(7), Inflammation : CK(3240) : AC(882)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Nitric Oxide Inhibitor : CK(223) : AC(108), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Intrathecal curcumin attenuates arthritic pain by inhibiting glial activation and the production of inflammatory mediators in the spinal cord.

Pubmed Data : Sci Rep. 2015 ;5:10278. Epub 2015 May 19. PMID: 25988362
Article Published Date : Dec 31, 2014
Authors : Jun-Jie Chen, Lin Dai, Lin-Xia Zhao, Xiang Zhu, Su Cao, Yong-Jing Gao
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Arthritis : CK(1964) : AC(312), Inflammation : CK(3240) : AC(882)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-1 beta downregulation : CK(478) : AC(205)
Additional Keywords : Dose Response : CK(1056) : AC(408)

Liposomal curcumin might be a promising tool for the treatment of inflammatory diseases.

Pubmed Data : In Vivo. 2016 07-08;30(4):413-419. PMID: 27381602
Article Published Date : Dec 31, 2015
Authors : Burkhard Kloesch, Lukas Gober, Silvia Loebsch, Brigitta Vcelar, Lawrence Helson, Guenter Steiner
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Inflammation : CK(3240) : AC(882)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-6 Downregulation : CK(1137) : AC(354), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)
Additional Keywords : Liposomal Curcumin : CK(2) : AC(2)

OP-Gel-Aloe treated wounds exhibited very rapid healing with 80% of the wound healing in just 8 days.

Pubmed Data : Int J Biol Macromol. 2015 Oct 31. Epub 2015 Oct 31. PMID: 26529192
Article Published Date : Oct 30, 2015
Authors : Mythili Tummalapalli, Morgane Berthet, Bernard Verrier, B L Deopura, M S Alam, Bhuvanesh Gupta
Study Type : Animal Study
Additional Links
Substances : Aloe Vera : CK(353) : AC(78), Curcumin : CK(4803) : AC(2175), Pectin : CK(66) : AC(9)
Diseases : Wound Healing : CK(539) : AC(161)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antimicrobial : CK(293) : AC(128)

Oral administration of curcumin reduces inflammation in the first six hours after experimentally zymosan-induced arthritis.

Pubmed Data : Acta Cir Bras. 2014 Nov ;29(11):727-34. PMID: 25424293
Article Published Date : Oct 31, 2014
Authors : Nilson Nonose, José Aires Pereira, Paulo Roberto Moura Machado, Murilo Rocha Rodrigues, Daniela Tiemi Sato, Carlos Augusto Real Martinez
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Inflammation: Neutrophil-Mediated : CK(12) : AC(7), Rheumatoid Arthritis : CK(706) : AC(117)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)
Additional Keywords : Natural Substances Versus Drugs : CK(1698) : AC(302)
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1905) : AC(215)

Oral administration of curcumin reduces intestinal inflammation in a mouse model of irritable bowel syndrome.

Pubmed Data : Dig Dis Sci. 2010 May;55(5):1272-7. Epub 2009 Jun 10. PMID: 19513843
Article Published Date : May 01, 2010
Authors : Victoria Y L Ung, Rae R Foshaug, Sarah M MacFarlane, Thomas A Churchill, Jason S G Doyle, Beate C Sydora, Richard N Fedorak
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Colitis : CK(255) : AC(111), Irritable Bowel Syndrome : CK(720) : AC(93)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-10 downregulation : CK(128) : AC(45)

Post-injury curcumin administration may improve patient outcome by reducing acute activation of microglia/macrophages and neuronal apoptosis.

Pubmed Data : J Neuroinflammation. 2014 ;11:59. Epub 2014 Mar 27. PMID: 24669820
Article Published Date : Dec 31, 2013
Authors : Hai-tao Zhu, Chen Bian, Ji-chao Yuan, Wei-hua Chu, Xin Xiang, Fei Chen, Cheng-shi Wang, Hua Feng, Jiang-Kai Lin
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Brain Inflammation : CK(274) : AC(145), Brain Injury: Traumatic : CK(99) : AC(30)
Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Anti-Inflammatory Agents : CK(4861) : AC(1630), Neuroprotective Agents : CK(2360) : AC(1099)

Resveratrol and curcumin reduce inflammation associated with acute small intestinal inflammation.

Pubmed Data : PLoS One. 2010;5(12):e15099. Epub 2010 Dec 3. PMID: 21151942
Article Published Date : Jan 01, 2010
Authors : Stefan Bereswill, Melba Muñoz, André Fischer, Rita Plickert, Lea-Maxie Haag, Bettina Otto, Anja A Kühl, Christoph Loddenkemper, Ulf B Göbel, Markus M Heimesaat
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Resveratrol : CK(1283) : AC(746)
Diseases : Gastrointestinal Inflammation : CK(118) : AC(41), Inflammatory Bowel Diseases : CK(1052) : AC(197)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-6 Downregulation : CK(1137) : AC(354), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Review: Curcumin has therapeutic potential in multiple sclerosis.

Pubmed Data : Int Immunopharmacol. 2011 Mar;11(3):323-30. Epub 2010 Sep 8. PMID: 20828641
Article Published Date : Mar 01, 2011
Authors : Lin Xie, Xiao-Kang Li, Shiro Takahara
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Inflammation : CK(3240) : AC(882), Multiple Sclerosis : CK(964) : AC(184)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Rice bran arabinoxylan and curcumin therapy may be of benefit to patients with early-stage B-cell lymphoid malignancies.

Pubmed Data : Integr Cancer Ther. 2016 Jun ;15(2):183-9. Epub 2016 May 6. PMID: 27154182
Article Published Date : May 31, 2016
Authors : Terry Golombick, Terrence H Diamond, Arumugam Manoharan, Rajeev Ramakrishna
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Rice Bran : CK(127) : AC(37)
Diseases : Leukemia: B-Cell : CK(16) : AC(6), Leukemia: Chronic Lymphocytic Leukemia (CLL) : CK(88) : AC(35), Smoldering multiple myeloma (SMM) : CK(10) : AC(1)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

The findings of the present trial suggested that curcumin may exert immunomodulatory effects via altering the circulating concentrations of IL-1β, IL-4, and VEGF.

Pubmed Data : ScientificWorldJournal. 2014 ;2014:898361. Epub 2014 Feb 11. PMID: 24678280
Article Published Date : Dec 31, 2013
Authors : Shiva Ganjali, Amirhossein Sahebkar, Elahe Mahdipour, Khadijeh Jamialahmadi, Sepideh Torabi, Saeed Akhlaghi, Gordon Ferns, Seyed Mohammad Reza Parizadeh, Majid Ghayour-Mobarhan
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Obesity : CK(3022) : AC(467)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Immunomodulatory : CK(1287) : AC(358), Interleukin-1 beta downregulation : CK(478) : AC(205), Interleukin-4 downregulation : CK(119) : AC(34), VEGFR3 inhibition : CK(12) : AC(3)
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1905) : AC(215)

The inhibitory effects of curcumin support its utility as a prophylactic and therapeutic agent for inflammatory bone diseases such as periodontitis.

Pubmed Data : J Pharm Bioallied Sci. 2015 Aug ;7(Suppl 2):S554-8. PMID: 26538916
Article Published Date : Jul 31, 2015
Authors : M Nagasri, M Madhulatha, S V V S Musalaiah, P Aravind Kumar, C H Murali Krishna, P Mohan Kumar
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Dental Plaque : CK(202) : AC(22), Periodontitis : CK(171) : AC(39)
Pharmacological Actions : Anti-Bacterial Agents : CK(1367) : AC(475), Anti-Inflammatory Agents : CK(4861) : AC(1630), NF-kappaB Inhibitor : CK(1114) : AC(694)

The molecular mechanisms of curcumins suppressive effects on tumorigenesis, angiogenesis and metastasis, focusing on NF-κB pathway.

Pubmed Data : Cytokine Growth Factor Rev. 2016 Jan 2. Epub 2016 Jan 2. PMID: 26774676
Article Published Date : Jan 01, 2016
Authors : Yunes Panahi, Behrad Darvishi, Mostafa Ghanei, Narges Jowzi, Fatemeh Beiraghdar, Behrang Shiri Varnamkhasti
Study Type : Review
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Cancers: All : CK(14773) : AC(4596), Inflammation : CK(3240) : AC(882)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Chemopreventive : CK(2835) : AC(787), NF-kappaB Inhibitor : CK(1114) : AC(694)

The present study provides new insight towards anti-asthmatic potential of intranasal curcumin at lower doses.

Pubmed Data : Int Immunopharmacol. 2016 Jan 4 ;31:200-206. Epub 2016 Jan 4. PMID: 26761722
Article Published Date : Jan 03, 2016
Authors : Subhashini, Preeti S Chauhan, D Dash, B N Paul, Rashmi Singh
Study Type : Insect Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Asthma : CK(1157) : AC(190)
Pharmacological Actions : Anti-Asthmatic Agents : CK(24) : AC(3), Anti-Inflammatory Agents : CK(4861) : AC(1630)

The study revealed that curcumin exerted antidepressant-like effects in CMS rats, partially due to its anti-inflammatory aptitude.

Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2013 Dec 2 ;47:33-9. Epub 2013 Jul 20. PMID: 23876788
Article Published Date : Dec 01, 2013
Authors : Hong Jiang, Zhen Wang, Yihe Wang, Kai Xie, Qingrui Zhang, Qinsong Luan, Wenqiang Chen, Dexiang Liu
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Stress : CK(623) : AC(103)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antidepressive Agents : CK(1115) : AC(168), MicroRNA modulator : CK(264) : AC(145), NF-kappaB Inhibitor : CK(1114) : AC(694)
Additional Keywords : Gene Expression Regulation : CK(431) : AC(214)

The synergistic effects between curcumin and MSCs therapy may hold great promise as a curative combination for HCC.

Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(18):8271-9. PMID: 26745072
Article Published Date : Dec 31, 2014
Authors : Ola M Tork, Eman F Khaleel, Omnia M Abdelmaqsoud
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Liver Cancer : CK(1235) : AC(462)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-6 Downregulation : CK(1137) : AC(354), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

These RCTs provide scientific evidence that supports the efficacy of turmeric extract and curcumin in the treatment of arthritis.

Pubmed Data : J Med Food. 2016 Aug ;19(8):717-29. PMID: 27533649
Article Published Date : Jul 31, 2016
Authors : James W Daily, Mini Yang, Sunmin Park
Study Type : Meta Analysis, Review
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Turmeric : CK(5032) : AC(2348)
Diseases : Arthritis : CK(1964) : AC(312), Osteoarthritis : CK(770) : AC(115)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

These results suggest that the protective effect of curcumin on LPS-induced acute lung injury is associated with AMPK activation.

Pubmed Data : J Anesth. 2015 Sep 3. Epub 2015 Sep 3. PMID: 26335543
Article Published Date : Sep 02, 2015
Authors : Joungmin Kim, Seong-Wook Jeong, Hui Quan, Cheol-Won Jeong, Jeong-Il Choi, Hong-Beom Bae
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Lipopolysaccharide-Induced Toxicity : CK(380) : AC(218)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-6 Downregulation : CK(1137) : AC(354), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

This meta-analysis of RCTs suggested a significant effect of curcumin in lowering circulating TNF-α concentration.

Pubmed Data : Pharmacol Res. 2016 Mar 26 ;107:234-242. Epub 2016 Mar 26. PMID: 27025786
Article Published Date : Mar 25, 2016
Authors : Amirhossein Sahebkar, Arrigo F G Cicero, Luis E Simental-Mendía, Bharat B Aggarwal, Subash C Gupta
Study Type : Meta Analysis
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Inflammation : CK(3240) : AC(882)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

This paper aims to further elucidate the anti-inflammatory molecular mechanisms of Curcumin.

Pubmed Data : Acta Pharm Sin B. 2015 Nov ;5(6):590-5. Epub 2015 Oct 21. PMID: 26713275
Article Published Date : Oct 31, 2015
Authors : Yanxiong Gan, Shichao Zheng, Jan P A Baak, Silei Zhao, Yongfeng Zheng, Nini Luo, Wan Liao, Chaomei Fu
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Inflammation : CK(3240) : AC(882)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

This study identifies oral supplementation with curcumin as a potential therapeutic strategy to improve intestinal barrier function and prevent the development of metabolic diseases.

Pubmed Data : PLoS One. 2014 ;9(9):e108577. Epub 2014 Sep 24. PMID: 25251395
Article Published Date : Dec 31, 2013
Authors : Siddhartha S Ghosh, Jinghua Bie, Jing Wang, Shobha Ghosh
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Atherosclerosis : CK(601) : AC(150), Metabolic Diseases : CK(411) : AC(75)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)
Anti Therapeutic Actions : Western Diet : CK(131) : AC(35)

This study provides strong evidence that at least some of the neuroprotective effects of curcumin against OGD/R are mediated by PPARγ activation.

Pubmed Data : J Neurosci Res. 2014 Nov ;92(11):1549-59. Epub 2014 Jun 26. PMID: 24975470
Article Published Date : Oct 31, 2014
Authors : Zun-Jing Liu, Hong-Qiang Liu, Cheng Xiao, Hui-Zhen Fan, Qing Huang, Yun-Hai Liu, Yu Wang
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Hypoxia: Brain : CK(10) : AC(6)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Neuroprotective Agents : CK(2360) : AC(1099)

Topical curcumin can inhibit deleterious effects of upper respiratory tract bacteria on human oropharyngeal cells.

Pubmed Data : Support Care Cancer. 2010 May 14. Epub 2010 May 14. PMID: 20467756
Article Published Date : May 14, 2010
Authors : Sonja Lüer, Rolf Troller, Marion Jetter, Violeta Spaniol, Christoph Aebi
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Chemotherapy-Induced Toxicity : CK(1033) : AC(327), Mucositis : CK(66) : AC(13), Upper Respiratory Infections : CK(950) : AC(114)
Pharmacological Actions : Anti-Bacterial Agents : CK(1367) : AC(475), Anti-Inflammatory Agents : CK(4861) : AC(1630)

Turmeric extract exhibits anti-Alzheimer properties.

Pubmed Data : Curr Alzheimer Res. 2011 Aug 30. Epub 2011 Aug 30. PMID: 21875408
Article Published Date : Aug 30, 2011
Authors : R Douglas Shytle, J Tan, P C Bickford, K Rezai-Zadeh, L Hou, J Zeng, P R Sanberg, C D Sanberg, R S Alberte, R C Fink, B Roschek
Study Type : Transgenic Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Alzheimer's Disease : CK(1292) : AC(382), Brain: Microglial Activation : CK(82) : AC(53), Brain Inflammation : CK(274) : AC(145)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Neuroprotective Agents : CK(2360) : AC(1099)

Turmeric gel can be effectively used as an adjunct to mechanical plaque control in the prevention of plaque and gingivitis.

Pubmed Data : Natl J Maxillofac Surg. 2015 Jan-Jun;6(1):67-71. PMID: 26668456
Article Published Date : Dec 31, 2014
Authors : Vibha Singh, Anjani Kumar Pathak, Mahesh Pal, Sagar Sareen, Kopal Goel
Study Type : Human Study
Additional Links
Substances : Turmeric : CK(5032) : AC(2348)
Diseases : Dental Plaque : CK(202) : AC(22), Gingivitis : CK(253) : AC(37)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Prostaglandin PGE2 downregulation : CK(96) : AC(46)

Turmeric reduces inflammatory cells in hamster opisthorchiasis.

Pubmed Data : Parasitol Res. 2009 Oct;105(5):1459-63. Epub 2009 Jul 25. PMID: 19633869
Article Published Date : Oct 01, 2009
Authors : Sirintip Boonjaraspinyo, Thidarut Boonmars, Chantana Aromdee, Tuanchai Srisawangwong, Butsara Kaewsamut, Somchai Pinlaor, Puangrat Yongvanit, Anucha Puapairoj
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Turmeric : CK(5032) : AC(2348)
Diseases : Opisthorchiasis : CK(1) : AC(1)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)

Willow oil, curcuma, and garlic have potent anti-inflammatory and analgesic properties.

Pubmed Data : Avicenna J Phytomed. 2015 May-Jun;5(3):182-202. PMID: 26101752
Article Published Date : Apr 30, 2015
Authors : Shahla Mahdizadeh, Maryam Khaleghi Ghadiri, Ali Gorji
Study Type : Review
Additional Links
Substances : Garlic : CK(722) : AC(226), Turmeric : CK(5032) : AC(2348), Willow Bark : CK(23) : AC(4)
Diseases : Chronic Pain : CK(206) : AC(33), Inflammation : CK(3240) : AC(882)
Pharmacological Actions : Analgesics : CK(1327) : AC(217), Anti-Inflammatory Agents : CK(4861) : AC(1630)

This document is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

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