Focused Research Topics Turmeric &amp; Anti-Inflammatory Agents

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

A combination of resveratrol and curcumin is effective against aluminum chloride-induced neuroinflammation in rats.

Pubmed Data : J Alzheimers Dis. 2017 Feb 7. Epub 2017 Feb 7. PMID: 28222524

Article Published Date : Feb 06, 2017

Authors : Amira Zaky, Ahmad Bassiouny, Mahitab Farghaly, Bassma M El-Sabaa

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Resveratrol : CK(3228) : AC(1513)

Diseases : Aluminum Toxicity : CK(735) : AC(318), Brain Inflammation : CK(1784) : AC(928)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949)

Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

Problem Substances : Aluminum Chloride : CK(192) : AC(95)

A combination of Tamarindus indica seeds and Curcuma longa extracts improves knee joint function and alleviates pain.

Pubmed Data : Int J Med Sci. 2019 ;16(6):845-853. Epub 2019 Jun 2. PMID: 31337958

Article Published Date : Dec 31, 2018

Authors : Posani Srinivas Rao, Yendluri Sita Ramanjaneyulu, Victor R Prisk, Leon J Schurgers

Study Type : Human Study

Additional Links

Substances : Tamarind : CK(143) : AC(41), Turmeric : CK(9427) : AC(3904)

Diseases : Pain: Musculoskeletal : CK(94) : AC(13)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

A comparative study of curcumin-loaded lipid-based nanocarriers in the treatment of inflammatory bowel disease.

Pubmed Data : Colloids Surf B Biointerfaces. 2016 Jul 1 ;143:327-335. Epub 2016 Mar 16. PMID: 27022873

Article Published Date : Jun 30, 2016

Authors : Ana Beloqui, Patrick B Memvanga, Régis Coco, Sonia Reimondez-Troitiño, Mireille Alhouayek, Giulio G Muccioli, María José Alonso, Noemi Csaba, María de la Fuente, Véronique Préat

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Colitis : CK(1542) : AC(735), Inflammatory Bowel Diseases : CK(3196) : AC(926)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

A complex of curcumin and phosphatidylcholine is effective in reducing the symptoms of ostearthritis.

Pubmed Data : Altern Med Rev. 2010 Dec;15(4):337-44. PMID: 21194249

Article Published Date : Dec 01, 2010

Authors : Gianni Belcaro, Maria Rosaria Cesarone, Mark Dugall, Luciano Pellegrini, Andrea Ledda, Maria Giovanna Grossi, Stefano Togni, Giovanni Appendino

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Phosphatidylcholine : CK(112) : AC(24)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

A curcumin extract is appropriate for the care of patients with joint problems and may also contribute to the regeneration of cartilage.

Pubmed Data : Open Rheumatol J. 2014 ;8:77-81. Epub 2014 Oct 17. PMID: 25352926

Article Published Date : Dec 31, 2013

Authors : Thierry Appelboom, Nathalie Maes, Adelin Albert

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Chronic Pain : CK(1524) : AC(284), Osteoarthritis : CK(2225) : AC(627), Quality of Life: Poor : CK(559) : AC(58)

Pharmacological Actions : Analgesics : CK(9680) : AC(1472), Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782), Significant Treatment Outcome : CK(4297) : AC(505)

A formulation containing Frankincense and Turmeric extracts demonstrated a greater improvement in the treatment of OA than celecoxib.

Pubmed Data : Mol Med Rep. 2013 Nov ;8(5):1542-8. Epub 2013 Aug 29. PMID: 24002213

Article Published Date : Oct 31, 2013

Authors : Reji Kizhakkedath

Study Type : Human Study

Additional Links

Substances : Frankincense : CK(1021) : AC(260), Turmeric : CK(9427) : AC(3904)

Diseases : Osteoarthritis: Knee : CK(2345) : AC(276)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782), Superiority of Natural Substances versus Drugs : CK(1875) : AC(394)

Problem Substances : Celecoxib : CK(76) : AC(9), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(3243) : AC(656)

A gel containing curcuma longa extract was efficient in treating gingivitis by reducing its inflammatory components.

Pubmed Data : J Clin Diagn Res. 2014 Dec ;8(12):ZC08-10. Epub 2014 Dec 5. PMID: 25654020

Article Published Date : Nov 30, 2014

Authors : H Nilofer Farjana, S C Chandrasekaran, Bagavad Gita

Study Type : Human Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Gingivitis : CK(628) : AC(90)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

A herbal formulation is a safe and effective intervention for management of joint discomfort.

Pubmed Data : J Med Food. 2018 May ;21(5):511-520. Epub 2018 Apr 30. PMID: 29708818

Article Published Date : Apr 30, 2018

Authors : Vasu Karlapudi, Anjaneya Venkata Vara Prasad Mungara, Krishanu Sengupta, Barbara A Davis, Siba Prasad Raychaudhuri

Study Type : Human Study

Additional Links

Substances : Frankincense : CK(1021) : AC(260), Frankincense : CK(1021) : AC(260), Turmeric : CK(9427) : AC(3904)

Diseases : Osteoarthritis: Knee : CK(2345) : AC(276)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669), Plant Extracts : CK(18762) : AC(6782)

A hot water extract of C. longa may help to improve systemic glucose metabolism in people with chronic low-grade inflammation.

Pubmed Data : Nutrients. 2022 Sep 13 ;14(18). Epub 2022 Sep 13. PMID: 36145139

Article Published Date : Sep 12, 2022

Authors : Ryusei Uchio, Chinatsu Okuda-Hanafusa, Ryosuke Saji, Kengo Kawasaki, Koutarou Muroyama, Shinji Murosaki, Yoshihiro Yamamoto, Yoshitaka Hirose

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : C-Reactive Protein : CK(3950) : AC(392), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

A literature review of the neuroprotective potency of some spice herbs.

Pubmed Data : J Tradit Complement Med. 2019 Apr ;9(2):98-105. Epub 2018 Apr 30. PMID: 30963044

Article Published Date : Mar 31, 2019

Authors : Mohammad Reza Khazdair, Akbar Anaeigoudari, Milad Hashemzehi, Reza Mohebbati

Study Type : Review

Additional Links

Substances : Coriandrum sativum : CK(94) : AC(52), Saffron : CK(1324) : AC(285), Thyme : CK(165) : AC(82), Turmeric : CK(9427) : AC(3904), Zataria multiflora : CK(321) : AC(96)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Neuroprotective Agents : CK(20061) : AC(7949), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

A novel demethylated curcuminoid exhibits neuroprotective and anti-inflammatory properties.

Pubmed Data : Antioxid Redox Signal. 2009 Mar;11(3):449-68. PMID: 18724833

Article Published Date : Mar 01, 2009

Authors : Savita Khanna, Han-A Park, Chandan K Sen, Trimurtulu Golakoti, Krishanu Sengupta, Somepalli Venkateswarlu, Sashwati Roy

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Neurodegenerative Diseases : CK(13103) : AC(4279)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949)

A pilot study to examine the effects of an anti-inflammatory supplement on eicosanoid derivatives in patients with chronic kidney disease.

Pubmed Data : J Altern Complement Med. 2017 Aug ;23(8):632-638. Epub 2017 Apr 4. PMID: 28375641

Article Published Date : Jul 31, 2017

Authors : Brian D Shelmadine, Rodney G Bowden, Jennifer J Moreillon, Matthew B Cooke, Peiying Yang, Erika Deike, Jackson O Griggs, Ron L Wilson

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Frankincense : CK(1021) : AC(260)

Diseases : Chronic Kidney Disease (CKD) : CK(1186) : AC(211), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

A polar extract of Curcuma longa protects cartilage homeostasis

Pubmed Data : Inflammopharmacology. 2018 Jan 8. Epub 2018 Jan 8. PMID: 29313174

Article Published Date : Jan 07, 2018

Authors : Chandrasekaran Chinampudur Velusami, Edwin Jothie Richard, Bharathi Bethapudi

Study Type : In Vitro Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Interleukin-6 Downregulation : CK(9337) : AC(3613), Interleukin-8 downregulation : CK(1107) : AC(402), Postaglandin PGE2 downregulation : CK(386) : AC(199), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

A polysaccharide extract of Curcuma longa significantly attenuated acute and chronic inflammation in rodent models.

Pubmed Data : Antiinflamm Antiallergy Agents Med Chem. 2015 Apr 7. Epub 2015 Apr 7. PMID: 25846947

Article Published Date : Apr 06, 2015

Authors : Ramanaiah Illuri, Bharathi Bethapudi, Senthilkumar Anandhakumar, Sasikumar Murugan, Joshua Allan Joseph, Deepak Mundkinajeddu, Amit Agarwal, Chandrasekaran Chinampudur Velusami

Study Type : Animal Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Substances : Alpha-Lipoic Acid : CK(1501) : AC(366), Curcumin : CK(7239) : AC(3319), EGCG (Epigallocatechin gallate) : CK(1587) : AC(820), Magnesium : CK(2799) : AC(368), NAC (N-acetyl-L-cysteine) : CK(1429) : AC(366), Probiotics : CK(9740) : AC(1711), Quercetin : CK(1876) : AC(855), Resveratrol : CK(3228) : AC(1513), Vitamin C : CK(6066) : AC(1408), Vitamin D : CK(11762) : AC(1712), Vitamin E : CK(3040) : AC(571), Zinc : CK(1957) : AC(345)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

A review focusing on the anti-inflammatory and anti-oxidant properties of curcumin and discuss its therapeutic potential in bipolar disorders.

Pubmed Data : Med Hypotheses. 2013 May ;80(5):606-12. Epub 2013 Feb 26. PMID: 23484676

Article Published Date : Apr 30, 2013

Authors : Elisa Brietzke, Rodrigo B Mansur, Andre Zugman, André F Carvalho, Danielle S Macêdo, Danielle S Cha, Vanessa C Abílio, Roger S McIntyre

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Bipolar Disorder : CK(489) : AC(68), Brain Inflammation : CK(1784) : AC(928)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroplasticity enhancement : CK(158) : AC(54), Neuroprotective Agents : CK(20061) : AC(7949)

Additional Keywords : Cytokines : CK(35) : AC(12)

A review of curcumin's effects.

Pubmed Data : Crit Rev Food Sci Nutr. 2017 Sep 2 ;57(13):2889-2895. PMID: 26528921

Article Published Date : Sep 01, 2017

Authors : Betül Kocaadam, Nevin Şanlier

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

A review of dietary supplements for treatment of endometriosis.

Pubmed Data : Acta Biomed. 2022 Mar 14 ;93(1):e2022159. Epub 2022 Mar 14. PMID: 35315418

Article Published Date : Mar 13, 2022

Authors : Pınar Yalçın Bahat, Işıl Ayhan, Eda ÜreyenÖzdemir, Ümit İnceboz, Engin Oral

Study Type : Review

Additional Links

Diseases : Endometriosis : CK(579) : AC(159)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Antiproliferative : CK(10001) : AC(7491)

A review of effective medicinal plants in the treatment of the cyclic mastalgia.

Pubmed Data : J Pharmacopuncture. 2019 Sep ;22(3):131-139. Epub 2019 Sep 30. PMID: 31673442

Article Published Date : Aug 31, 2019

Authors : Azin Niazi, Vafa Baradaran Rahimi, Hooman Hatami, Reza Shirazinia, Reza Esmailzadeh-Dizaji, Nafiseh Askari, Vahid Reza Askari

Study Type : Review

Additional Links

Substances : Chaste Tree (Chasteberry) : CK(54) : AC(15), Curcumin : CK(7239) : AC(3319), Ginkgo biloba : CK(2047) : AC(658), Nigella sativa (aka Black Seed) : CK(1912) : AC(494), St. Johns Wort : CK(401) : AC(118), Sweet Orange : CK(48) : AC(17), Wheat Germ : CK(88) : AC(31)

Diseases : Mastalgia : CK(123) : AC(12)

Pharmacological Actions : Analgesics : CK(9680) : AC(1472), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

A review of the biological and therapeutic activities, and anticancer properties of curcumin.

Pubmed Data : Exp Ther Med. 2015 Nov ;10(5):1615-1623. Epub 2015 Sep 17. PMID: 26640527

Article Published Date : Oct 31, 2015

Authors : Donatella Perrone, Fatima Ardito, Giovanni Giannatempo, Mario Dioguardi, Giuseppe Troiano, Lucio Lo Russo, Alfredo DE Lillo, Luigi Laino, Lorenzo Lo Muzio

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Arthritis : CK(5826) : AC(1505), Head and Neck Cancer : CK(797) : AC(189), Liver Cancer : CK(3119) : AC(1641), Lung Cancer : CK(3063) : AC(1429), Ovarian Cancer : CK(1029) : AC(509), Pancreatic Cancer : CK(1547) : AC(564), Prostate Cancer : CK(2805) : AC(1046), Skin Cancer : CK(1759) : AC(833)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anti-metastatic : CK(2870) : AC(2182), Antimutagenic Agents : CK(218) : AC(138), Apoptotic : CK(9585) : AC(7379), Cell cycle arrest : CK(2120) : AC(1715)

A review of the cancer chemoprevention by phytochemicals.

Pubmed Data : Molecules. 2017 Mar 3 ;22(3). Epub 2017 Mar 3. PMID: 28273819

Article Published Date : Mar 02, 2017

Authors : Haseeb Zubair, Shafquat Azim, Aamir Ahmad, Mohammad Aslam Khan, Girijesh Kumar Patel, Seema Singh, Ajay Pratap Singh

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), EGCG (Epigallocatechin gallate) : CK(1587) : AC(820), Honokiol : CK(435) : AC(271), Resveratrol : CK(3228) : AC(1513)

Diseases : Cancers: All : CK(36404) : AC(14363), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Chemoprotective Agents : CK(4278) : AC(1621)

A review of the molecular targets of curcumin in breast cancer.

Pubmed Data : Mol Med Rep. 2018 Nov 19. Epub 2018 Nov 19. PMID: 30483727

Article Published Date : Nov 18, 2018

Authors : Xinqiang Song, Mu Zhang, Erqin Dai, Yuan Luo

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Angiogenesis Inhibitors : CK(724) : AC(481), Anti-Inflammatory Agents : CK(39737) : AC(15858), Anti-metastatic : CK(2870) : AC(2182), Apoptotic : CK(9585) : AC(7379), Tumor Suppressor Protein p53 Upregulation : CK(755) : AC(554)

A review of the rundown of dietary supplements and their effects on inflammatory bowel disease.

Pubmed Data : Nutrients. 2020 May 14 ;12(5). Epub 2020 May 14. PMID: 32423084

Article Published Date : May 13, 2020

Authors : Bartosz Malinowski, Michał Wiciński, Maya M Sokołowska, Nicholas A Hill, Monika Szambelan

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Fiber : CK(1656) : AC(217), Oligosaccharides : CK(145) : AC(61), Polyphenols : CK(2736) : AC(1003), Probiotics : CK(9740) : AC(1711), Resveratrol : CK(3228) : AC(1513)

Diseases : Crohn's Disease : CK(242) : AC(55), Inflammatory Bowel Diseases : CK(3196) : AC(926), Ulcerative Colitis : CK(1411) : AC(447)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Gastrointestinal Agents : CK(7657) : AC(2274)

A review of the use of curcumin in psoriasis.

Pubmed Data : Open Access Maced J Med Sci. 2018 Jan 25 ;6(1):218-220. Epub 2018 Jan 21. PMID: 29484027

Article Published Date : Jan 24, 2018

Authors : Veronica Di Nardo, Serena Gianfaldoni, Georgi Tchernev, Uwe Wollina, Victoria Barygina, Jacopo Lotti, Farah Daaboul, Torello Lotti

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Psoriasis : CK(922) : AC(255)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

A review of turmeric and its major compound curcumin on health.

Pubmed Data : Front Pharmacol. 2020 ;11:01021. Epub 2020 Sep 15. PMID: 33041781

Article Published Date : Dec 31, 2019

Authors : Javad Sharifi-Rad, Youssef El Rayess, Alain Abi Rizk, Carmen Sadaka, Raviella Zgheib, Wissam Zam, Simona Sestito, Simona Rapposelli, Katarzyna Neffe-Skocińska, Dorota Zielińska, Bahare Salehi, William N Setzer, Noura S Dosoky, Yasaman Taheri, Marc El Beyrouthy, Miquel Martorell, Elise Adrian Ostrander, Hafiz Ansar Rasul Suleria, William C Cho, Alfred Maroyi, Natália Martins

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963), Hepatoprotective : CK(8989) : AC(3831), Neuroprotective Agents : CK(20061) : AC(7949)

A review on curcumin colon-targeted oral drug delivery systems for the treatment of inflammatory bowel disease.

Pubmed Data : Inflammopharmacology. 2023 Feb 9. Epub 2023 Feb 9. PMID: 36757584

Article Published Date : Feb 08, 2023

Authors : Hossein Shahdadi Sardou, Paria Rahnama Vosough, Mohammadreza Abbaspour, Abbas Akhgari, Thozhukat Sathyapalan, Amirhossein Sahebkar

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Inflammatory Bowel Diseases : CK(3196) : AC(926)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Gastrointestinal Agents : CK(7657) : AC(2274), Interleukin-6 Downregulation : CK(9337) : AC(3613), NF-kappaB Inhibitor : CK(5952) : AC(3464), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

A review on curcumins wound healing properties provides evidence for enhanced granulation tissue formation, collagen deposition, tissue remodeling and wound contraction.

Pubmed Data : Life Sci. 2014 Oct 22 ;116(1):1-7. Epub 2014 Sep 6. PMID: 25200875

Article Published Date : Oct 21, 2014

Authors : Dania Akbik, Maliheh Ghadiri, Wojciech Chrzanowski, Ramin Rohanizadeh

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716), Wound Healing : CK(4555) : AC(1412)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

A systematic review on curcumin and anti-Plasmodium berghei effects.

Pubmed Data : Curr Drug Discov Technol. 2022 ;19(3):e150322202249. PMID: 35293297

Article Published Date : Dec 31, 2021

Authors : Pegah Shakib, Hamed Kalani, Jeffery Ho, Mehrdad Dolatshah, Sana Amiri, Kourosh Cheraghipour

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Malaria : CK(303) : AC(135)

Pharmacological Actions : Anti-Infective Agents : CK(92) : AC(47), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antiparasitic Agents : CK(320) : AC(185)

A variety of natural substances have preventive potential in osteoarthritis and rheumatoid arthritis.

Pubmed Data : Arthritis Res Ther. 2011 Feb 3;13(1):102. Epub 2011 Feb 3. PMID: 21345249

Article Published Date : Feb 03, 2011

Authors : Sarah Khalifé, Muhammad Zafarullah

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), EGCG (Epigallocatechin gallate) : CK(1587) : AC(820), Pomegranate : CK(1800) : AC(573), Resveratrol : CK(3228) : AC(1513)

Diseases : Osteoarthritis : CK(2225) : AC(627), Rheumatoid Arthritis : CK(2322) : AC(562)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Acute effects of turmeric extracts on knee joint pain.

Pubmed Data : J Med Food. 2020 Jul 29. Epub 2020 Jul 29. PMID: 32749918

Article Published Date : Jul 28, 2020

Authors : Lorena Calderón-Pérez, Elisabet Llauradó, Judit Companys, Laura Pla-Pagà, Noemí Boqué, Francesc Puiggrós, Rosa-M Valls, Anna Pedret, Josep Manuel Llabrés, Lluís Arola, Rosa Solà

Study Type : Human Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Arthritis : CK(5826) : AC(1505)

Pharmacological Actions : Analgesics : CK(9680) : AC(1472), Anti-Inflammatory Agents : CK(39737) : AC(15858)

Administering curcumin may alleviate cerebral inflammation resulting from intracerebral hemorrhage.

Pubmed Data : Neurosci Lett. 2016 Mar 26 ;620:74-82. Epub 2016 Mar 26. PMID: 27026486

Article Published Date : Mar 25, 2016

Authors : Wei Liu, Jichao Yuan, Haitao Zhu, Xuan Zhang, Lan Li, Xiaojun Liao, Zexian Wen, Yaxing Chen, Hua Feng, Jiangkai Lin

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain Inflammation : CK(1784) : AC(928), Cerebral Ischemia : CK(1183) : AC(566)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interferon Gamma Reducer : CK(569) : AC(215), Interleukin-17 downregulation : CK(502) : AC(192)

Alternations of NF-κB signaling by natural compounds in muscle-derived cancers.

Pubmed Data : Int J Mol Sci. 2023 Jul 25 ;24(15). Epub 2023 Jul 25. PMID: 37569275

Article Published Date : Jul 24, 2023

Authors : Justyna Radzka, Zofia Łapińska, Urszula Szwedowicz, Agnieszka Gajewska-Naryniecka, Agnieszka Gizak, Julita Kulbacka

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), EGCG (Epigallocatechin gallate) : CK(1587) : AC(820), Quercetin : CK(1876) : AC(855), Resveratrol : CK(3228) : AC(1513)

Diseases : Rhabdomyosarcoma : CK(17) : AC(14)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antiproliferative : CK(10001) : AC(7491), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Ameliorative effect of curcumin against lead acetate-induced hemato-biochemical alterations, hepatotoxicity, and testicular oxidative damage.

Pubmed Data : Environ Sci Pollut Res Int. 2020 Apr ;27(10):10950-10965. Epub 2020 Jan 17. PMID: 31953765

Article Published Date : Mar 31, 2020

Authors : Fatma M Abdelhamid, Hebatallah A Mahgoub, Ahmed I Ateya

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Testicular Injury: Chemical/Metal Induced : CK(774) : AC(385)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Immunomodulatory : CK(6531) : AC(2360)

Problem Substances : Lead : CK(700) : AC(231)

Ameliorative effect of curcumin nanoparticles against monosodium iodoacetate-induced knee osteoarthritis.

Pubmed Data : Mediators Inflamm. 2022 ;2022:8353472. Epub 2022 Oct 14. PMID: 36578323

Article Published Date : Dec 31, 2021

Authors : Hadeer M Hamdalla, Rasha R Ahmed, Sanaa R Galaly, Ibrahim A Naguib, Badrah S Alghamdi, Osama M Ahmed, Ahmed Farghali, Manal Abdul-Hamid

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Osteoarthritis: Knee : CK(2345) : AC(276)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

An experimental comparison of the effects of propolis, curcumin, and methylprednisolone on crush injuries of the sciatic nerve.

Pubmed Data : Ann Plast Surg. 2015 Jun ;74(6):684-92. PMID: 24317243

Article Published Date : May 31, 2015

Authors : Serdar Yüce, Emre Cemal Gökçe, Ahmet Işkdemir, Emine Rabia Koç, Duran Berker Cemil, Aysun Gökçe, Mustafa F Sargon

Study Type : Animal Study

Additional Links

Substances : Bee Propolis : CK(883) : AC(290), Curcumin : CK(7239) : AC(3319)

Diseases : Nerve Injuries : CK(28) : AC(15), Sciatic Nerve Crush Injury : CK(211) : AC(104), Wound Healing : CK(4555) : AC(1412)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949)

An extract of turmeric and white mulberry could potentially be considered as a dietary supplement product for the management of arthritis.

Pubmed Data : Pharmacognosy Res. 2016 Apr-Jun;8(2):112-7. PMID: 27034601

Article Published Date : Mar 31, 2016

Authors : Mesfin Yimam, Young-Chul Lee, Breanna Moore, Ping Jiao, Mei Hong, Jeong-Bum Nam, Mi-Ran Kim, Tae-Woo Kim, Hyun-Jin Kim, Eu-Jin Hyun, Min Chu, Lidia Brownell, Qi Jia

Study Type : Animal Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904), White Mulberry : CK(156) : AC(66)

Diseases : Arthritis : CK(5826) : AC(1505)

Pharmacological Actions : Analgesics : CK(9680) : AC(1472), Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Natural Substances Versus Drugs : CK(2806) : AC(560), Plant Extracts : CK(18762) : AC(6782)

Problem Substances : Ibuprofen : CK(266) : AC(41)

Anti-inflammatory and -apoptotic effects of a long-term herbal extract treatment on DSS-induced colitis.

Pubmed Data : Nutr Metab (Lond). 2021 Aug 11 ;18(1):77. Epub 2021 Aug 11. PMID: 34380504

Article Published Date : Aug 10, 2021

Authors : Fatemeh Azizian-Farsani, Marcin Osuchowski, Navid Abedpoor, Farzad Seyed Forootan, Maryam Derakhshan, Mohammad Hossein Nasr-Esfahani, Mohammad Hasan Sheikhha, Kamran Ghaedi

Study Type : Animal Study

Additional Links

Substances : Frankincense : CK(1021) : AC(260), Ginger : CK(1593) : AC(479), Turmeric : CK(9427) : AC(3904)

Diseases : Colitis : CK(1542) : AC(735)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613)

Anti-inflammatory effect of combined tetramethylpyrazine, resveratrol and curcumin in vivo.

Pubmed Data : BMC Complement Altern Med. 2017 Apr 27 ;17(1):233. Epub 2017 Apr 27. PMID: 28449676

Article Published Date : Apr 26, 2017

Authors : Long Chen, Tianjun Liu, Qiangsong Wang, Juan Liu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Ligustrazine : CK(150) : AC(72), Resveratrol : CK(3228) : AC(1513)

Diseases : Arthritis : CK(5826) : AC(1505), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), NF-kappaB Inhibitor : CK(5952) : AC(3464), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Additional Keywords : Phytotherapy : CK(4003) : AC(1031), Plant Extracts : CK(18762) : AC(6782)

Anti-inflammatory effect of Curcuma longa and Allium hookeri co-treatment via NF-κB and COX-2 pathways.

Pubmed Data : Sci Rep. 2020 Mar 31 ;10(1):5718. Epub 2020 Mar 31. PMID: 32235914

Article Published Date : Mar 30, 2020

Authors : Soon-Young Lee, Seung-Sik Cho, YongChun Li, Chun-Sik Bae, Kyung Mok Park, Dae-Hun Park

Study Type : In Vitro Study

Additional Links

Substances : Onion : CK(511) : AC(151), Turmeric : CK(9427) : AC(3904)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Anti-inflammatory effect of curcuminoids and their analogs in hyperosmotic human corneal limbus epithelial cells.

Pubmed Data : BMC Complement Med Ther. 2024 Apr 23 ;24(1):172. Epub 2024 Apr 23. PMID: 38654265

Article Published Date : Apr 22, 2024

Authors : Ngamjit Kasetsuwan, Usanee Reinprayoon, Lita Uthaithammarat, Amornpun Sereemaspun, Nutchanart Sae-Liang, Waraluck Chaichompoo, Apichart Suksamrarn

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Curcuminoids : CK(7851) : AC(3498), Demethoxycurcumin : CK(80) : AC(53), Tetrahydrocurcumin : CK(173) : AC(99)

Diseases : Eye Damage : CK(230) : AC(99), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Anti-inflammatory effect of different curcumin preparations on adjuvant-induced arthritis.

Pubmed Data : BMC Complement Med Ther. 2021 Jan 21 ;21(1):39. Epub 2021 Jan 21. PMID: 33478498

Article Published Date : Jan 20, 2021

Authors : Ieva Rinkunaite, Egidijus Simoliunas, Milda Alksne, Dominyka Dapkute, Virginija Bukelskiene

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) : CK(59) : AC(18)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Anti-inflammatory effects of curcumin-loaded niosomes on respiratory syncytial virus infection in a mice model.

Pubmed Data : J Med Microbiol. 2022 Apr ;71(4). PMID: 35417322

Article Published Date : Mar 31, 2022

Authors : Saeed Samadizadeh, Mehdi Sheikh Arabi, Mohammad Yasaghi, Vahid Salimi, Alijan Tabarraei, Abdolvahab Moradi, Alireza Tahamtan

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Respiratory Syncytial Virus Infections : CK(162) : AC(58)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Anti-inflammatory effects of oral supplementation with curcumin.

Pubmed Data : Nutr Rev. 2021 Aug 9 ;79(9):1043-1066. PMID: 34378053

Article Published Date : Aug 08, 2021

Authors : Jessica J A Ferguson, Kylie A Abbott, Manohar L Garg

Study Type : Meta Analysis, Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-10 upregulation : CK(1296) : AC(436), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Anti-inflammatory, antioxidant, and immunomodulatory effects of curcumin in ovalbumin-sensitized rat.

Pubmed Data : Biofactors. 2017 Jul 8 ;43(4):567-576. Epub 2017 May 16. PMID: 28509396

Article Published Date : Jul 07, 2017

Authors : Farzaneh Shakeri, Mohammad Hossein Boskabady

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Immune Dysregulation: TH1/TH2 imbalance : CK(223) : AC(66)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Immunomodulatory : CK(6531) : AC(2360)

Anti-inflammatory, wound healing, and anti-diabetic effects of pure active compounds present in the Ryudai gold variety of Curcuma longa.

Pubmed Data : Molecules. 2024 Jun 12 ;29(12). Epub 2024 Jun 12. PMID: 38930859

Article Published Date : Jun 11, 2024

Authors : Md Zahorul Islam, Jesmin Akter, Md Amzad Hossain, Md Shafiqul Islam, Purba Islam, Chayon Goswami, Ha Thi Thanh Nguyen, Atsushi Miyamoto

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)

Diseases : Hyperglycemia : CK(2240) : AC(709), Wound Healing : CK(4555) : AC(1412)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hypoglycemic Agents : CK(9221) : AC(2076)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Anti-neuroinflammatory and neuroprotective effect of Intermedin B isolated from the Curcuma longa.

Pubmed Data : Int J Mol Sci. 2023 Apr 17 ;24(8). Epub 2023 Apr 17. PMID: 37108568

Article Published Date : Apr 16, 2023

Authors : Hwan Lee, Zhiming Liu, Linsha Dong, Dae Young Lee, Dahye Yoon, Hyuncheol Oh, Youn-Chul Kim, Ren-Bo An, Dong-Sung Lee

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain Inflammation : CK(1784) : AC(928), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Anti-obesity effects of polyphenol intake: current status and future possibilities.

Pubmed Data : Int J Mol Sci. 2020 Aug 6 ;21(16). Epub 2020 Aug 6. PMID: 32781724

Article Published Date : Aug 05, 2020

Authors : Mariarosaria Boccellino, Stefania D'Angelo

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Polyphenols : CK(2736) : AC(1003), Quercetin : CK(1876) : AC(855), Resveratrol : CK(3228) : AC(1513)

Diseases : Obesity : CK(11004) : AC(2672)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Additional Keywords : Anti-Obesity Agents : CK(5172) : AC(1320)

Anti-osteoarthritic effects of an herbal composition LI73014F2 on interleukin-1β-induced primary human articular chondrocytes.

Pubmed Data : Molecules. 2020 Apr 27 ;25(9). Epub 2020 Apr 27. PMID: 32349389

Article Published Date : Apr 26, 2020

Authors : Hae Lim Kim, Hae Jin Lee, Dong-Ryung Lee, Bong-Keun Choi, Seung Hwan Yang

Study Type : In Vitro Study

Additional Links

Substances : Frankincense : CK(1021) : AC(260), Frankincense : CK(1021) : AC(260), Turmeric : CK(9427) : AC(3904)

Pharmacological Actions : 5-Lipoxygenase Inhibitor : CK(48) : AC(31), Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(944) : AC(588), Matrix metalloproteinase-3 (MMP-3) inhibitor : CK(238) : AC(107), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(1141) : AC(720), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Anti-viral potential and modulation of Nrf2 by curcumin.

Pubmed Data : Antioxidants (Basel). 2020 Dec 4 ;9(12). Epub 2020 Dec 4. PMID: 33291560

Article Published Date : Dec 03, 2020

Authors : Mahdie Rahban, Mehran Habibi-Rezaei, Mansoureh Mazaheri, Luciano Saso, Ali A Moosavi-Movahedi

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210), Amyotrophic Lateral Sclerosis : CK(803) : AC(216), Anxiety : CK(4246) : AC(759), Autism Spectrum Disorders : CK(3722) : AC(571), Dementia : CK(2211) : AC(386), Depression : CK(9574) : AC(1756), Depression : CK(9574) : AC(1756), Huntington Disease : CK(222) : AC(103), Multiple Sclerosis : CK(2432) : AC(557), Parkinson's Disease : CK(3012) : AC(1116), Stroke : CK(4410) : AC(773)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Nrf2 activation : CK(3156) : AC(1794)

Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies.

Pubmed Data : Nutrients. 2020 Jan 1 ;12(1). Epub 2020 Jan 1. PMID: 31906278

Article Published Date : Dec 31, 2019

Authors : Danja J Den Hartogh, Alessandra Gabriel, Evangelia Tsiani

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Diabetes Mellitus: Type 2 : CK(12953) : AC(2579)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Hypoglycemic Agents : CK(9221) : AC(2076), Immunomodulatory : CK(6531) : AC(2360), Renoprotective : CK(4544) : AC(1971)

Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults.

Pubmed Data : Cytokine. 2023 Apr ;164:156144. Epub 2023 Feb 15. PMID: 36804260

Article Published Date : Mar 31, 2023

Authors : Mohammad Jafar Dehzad, Hamid Ghalandari, Mehran Nouri, Moein Askarpour

Study Type : Meta Analysis, Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : C-Reactive Protein : CK(3950) : AC(392), Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Interleukin-6 Downregulation : CK(9337) : AC(3613), Superoxide Dismutase Up-regulation : CK(2383) : AC(928), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Antioxidants ameliorated Tetrachlorobenzoquinone induced ROS generation as well as the activation of NF-κB.

Pubmed Data : Environ Toxicol Pharmacol. 2015 Dec 21 ;41:241-250. Epub 2015 Dec 21. PMID: 26745386

Article Published Date : Dec 20, 2015

Authors : Juanli Fu, Qiong Shi, Xiufang Song, Xiaomin Xia, Chuanyang Su, Zixuan Liu, Erqun Song, Yang Song

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), NAC (N-acetyl-L-cysteine) : CK(1429) : AC(366), Vitamin E : CK(3040) : AC(571)

Diseases : Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Problem Substances : Persistent organic pollutants (POPs) : CK(231) : AC(33)

Ar-turmerone exerts anti-proliferative and anti-inflammatory activities.

Pubmed Data : Inflammation. 2020 Apr ;43(2):478-486. PMID: 31773440

Article Published Date : Mar 31, 2020

Authors : Sen Yang, Jia Liu, Jianxia Jiao, Linjun Jiao

Study Type : Animal Study

Additional Links

Substances : Turmerones : CK(32) : AC(23)

Diseases : Psoriasis : CK(922) : AC(255)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antiproliferative : CK(10001) : AC(7491), Interleukin-6 Downregulation : CK(9337) : AC(3613), Interleukin-8 downregulation : CK(1107) : AC(402)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Aromatic-turmerone ameliorates DSS-induced ulcerative colitis via modulating gut microbiota in mice.

Pubmed Data : Inflammopharmacology. 2022 Jul 6. Epub 2022 Jul 6. PMID: 35794287

Article Published Date : Jul 05, 2022

Authors : Chunlian Li, Weicheng Zhang, Xianyi Wu, Qiuyang Cai, Zekai Tan, Zhengyi Hong, Shiyuan Huang, Yanghe Yuan, Lewen Yao, Lanyue Zhang

Study Type : Animal Study

Additional Links

Substances : Turmerones : CK(32) : AC(23)

Diseases : Ulcerative Colitis : CK(1411) : AC(447)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Gastrointestinal Agents : CK(7657) : AC(2274), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Ayurvedic polyherbal formulation in moderate SARS-CoV-2 infections and its impact on inflammatory biomarkers.

Pubmed Data : Phytother Res. 2022 Nov 23. Epub 2022 Nov 23. PMID: 36419388

Article Published Date : Nov 22, 2022

Authors : Deepa Chitre, Satej Nadkarni, Namdev Jagtap, Rahul Tulle, Amol Gitte, Prashant Rahate, Sunetra Chaskar, Debendranath Dey

Study Type : In Vitro Study

Additional Links

Substances : Ashwagandha : CK(748) : AC(301), Frankincense : CK(1021) : AC(260), Ginger : CK(1593) : AC(479), Turmeric : CK(9427) : AC(3904)

Diseases : Coronavirus Infection : CK(3250) : AC(986)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613)

Beneficial effects of curcumin in polycystic ovary syndrome.

Pubmed Data : Curr Med Chem. 2024 Oct 17. Epub 2024 Oct 17. PMID: 39421997

Article Published Date : Oct 16, 2024

Authors : Tayybeh Khamar, Najmeh Jahani, Amir Masoud Jafari-Nozad, Tahereh Farkhondeh, Saeed Samarghandian

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Polycystic Ovary Syndrome : CK(2116) : AC(332)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Beneficial effects on abdominal bloating with an innovative food-grade formulation of Curcuma longa and Boswellia serrata extracts in subjects with irritable bowel syndrome.

Pubmed Data : Nutrients. 2022 Jan 18 ;14(3). Epub 2022 Jan 18. PMID: 35276778

Article Published Date : Jan 17, 2022

Authors : Attilio Giacosa, Antonella Riva, Giovanna Petrangolini, Pietro Allegrini, Teresa Fazia, Luisa Bernardinelli, Gabriella Peroni, Mariangela Rondanelli

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Frankincense : CK(1021) : AC(260)

Diseases : Dysbiosis : CK(2038) : AC(586), Irritable Bowel Syndrome : CK(1492) : AC(230)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Benefits of curcumin in brain disorders.

Pubmed Data : Biofactors. 2019 Sep ;45(5):666-689. Epub 2019 Jun 11. PMID: 31185140

Article Published Date : Aug 31, 2019

Authors : Abid Bhat, Arehally M Mahalakshmi, Bipul Ray, Sunanda Tuladhar, Tousif A Hediyal, Esther Manthiannem, Jagadeeswari Padamati, Ramesh Chandra, Saravana B Chidambaram, Meena K Sakharkar

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Benefits of turmeric supplementation for skin health in chronic diseases.

Pubmed Data : Crit Rev Food Sci Nutr. 2020 Jul 27:1-15. Epub 2020 Jul 27. PMID: 32713186

Article Published Date : Jul 26, 2020

Authors : Isabella Rosa da Mata, Sheila Rosa da Mata, Rafaella Camara Rocha Menezes, Larissa Slongo Faccioli, Kathleen Krüger Bandeira, Simone Morelo Dal Bosco

Study Type : Review

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Oral Lichen Planus : CK(430) : AC(58), Pruritus : CK(114) : AC(20), Psoriasis : CK(922) : AC(255), Skin Cancer : CK(1759) : AC(833), Skin Diseases : CK(201) : AC(64)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Bioactive yoghurt containing curcumin and chlorogenic acid reduces inflammation in postmenopausal women.

Pubmed Data : Nutrients. 2022 Nov 2 ;14(21). Epub 2022 Nov 2. PMID: 36364884

Article Published Date : Nov 01, 2022

Authors : Noha Ahmed Nasef, Rohith N Thota, Anthony N Mutukumira, Kay Rutherfurd-Markwick, Martin Dickens, Pramod Gopal, Harjinder Singh, Manohar L Garg

Study Type : Human Study

Additional Links

Substances : Chlorogenic Acid : CK(431) : AC(189), Curcumin : CK(7239) : AC(3319), Yoghurt : CK(1142) : AC(159)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Bioavailable turmeric extract is as effective as paracetamol in reducing pain and other symptoms of knee osteoarthritis.

Pubmed Data : Trials. 2021 Jan 30 ;22(1):105. Epub 2021 Jan 30. PMID: 33516238

Article Published Date : Jan 29, 2021

Authors : Shubha Singhal, Nazer Hasan, Kirti Nirmal, Rohit Chawla, Shalini Chawla, Bhupinder Singh Kalra, Anil Dhal

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)

Diseases : Osteoarthritis: Knee : CK(2345) : AC(276)

Pharmacological Actions : Analgesics : CK(9680) : AC(1472), Anti-Inflammatory Agents : CK(39737) : AC(15858), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Additional Keywords : Natural Substances Versus Drugs : CK(2806) : AC(560), Plant Extracts : CK(18762) : AC(6782)

Biochemical characterization and anti-inflammatory properties of an isothiocyanate-enriched moringa seed extract.

Pubmed Data : PLoS One. 2017 ;12(8):e0182658. Epub 2017 Aug 8. PMID: 28792522

Article Published Date : Dec 31, 2016

Authors : Asha Jaja-Chimedza, Brittany L Graf, Charlotte Simmler, Youjin Kim, Peter Kuhn, Guido F Pauli, Ilya Raskin

Study Type : In Vitro Study

Additional Links

Substances : Isothiocyanates : CK(1659) : AC(819), Moringa oleifera : CK(748) : AC(377), Turmeric : CK(9427) : AC(3904)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613)

Additional Keywords : Phytotherapy : CK(4003) : AC(1031), Plant Extracts : CK(18762) : AC(6782)

Bisdemethoxycurcumin and curcumin alleviate inflammatory bowel disease.

Pubmed Data : J Agric Food Chem. 2025 Feb 12 ;73(6):3494-3506. Epub 2025 Jan 28. PMID: 39873626

Article Published Date : Feb 11, 2025

Authors : Kai-Yu Hsu, Anju Majeed, Chi-Tang Ho, Min-Hsiung Pan

Study Type : Animal Study

Additional Links

Substances : Bisdemethoxycurcumin : CK(123) : AC(71), Curcumin : CK(7239) : AC(3319)

Diseases : Inflammatory Bowel Diseases : CK(3196) : AC(926)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Gastroprotective : CK(1692) : AC(701), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Blockade of periostin-dependent migration and adhesion by curcumol via inhibition of nuclear factor kappa B signaling in hepatic stellate cells.

Pubmed Data : Toxicology. 2020 07 ;440:152475. Epub 2020 Apr 25. PMID: 32344006

Article Published Date : Dec 31, 2019

Authors : Yan Jia, Liyuan Gao, Xiang Yang, Feng Zhang, Anping Chen, Shijun Wang, Jiangjuan Shao, Shanzhong Tan, Shizhong Zheng

Study Type : In Vitro Study

Additional Links

Substances : Curcumol : CK(109) : AC(78)

Diseases : Liver Fibrosis : CK(882) : AC(399)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Boswellia serrata and Curcuma longa dietary supplementation alleviated short and partially mid-term pain.

Pubmed Data : Musculoskelet Surg. 2015 May 10. Epub 2015 May 10. PMID: 25957549

Article Published Date : May 09, 2015

Authors : G Merolla, F Dellabiancia, A Ingardia, P Paladini, G Porcellini

Study Type : Human Study

Additional Links

Substances : Boswellia : CK(123) : AC(30), Turmeric : CK(9427) : AC(3904)

Diseases : Tendon Injury : CK(377) : AC(91)

Pharmacological Actions : Analgesics : CK(9680) : AC(1472), Anti-Inflammatory Agents : CK(39737) : AC(15858)

Both C. longa and curcumin improved paraquat-induced systemic and lung inflammation and oxidative stress.

Pubmed Data : Avicenna J Phytomed. 2022 Jul-Aug;12(4):414-424. PMID: 35782772

Article Published Date : Jun 30, 2022

Authors : Seyedeh Zahra Ghasemi, Arghavan Memarzia, Sepideh Behrouz, Zahra Gholamnezhad, Mohammad Hossein Boskabady

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)

Diseases : Lung Damage : CK(441) : AC(192), Pesticide Toxicity : CK(1467) : AC(478)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Problem Substances : Paraquat : CK(190) : AC(94)

Both caloric restriction and dietary curcumin can improve obesity-associated comorbidities.

Pubmed Data : PLoS One. 2015 ;10(10):e0140431. Epub 2015 Oct 16. PMID: 26473740

Article Published Date : Dec 31, 2014

Authors : Marjana Rahman Sarker, Susan Franks, Nathalie Sumien, Nopporn Thangthaeng, Frank Filipetto, Michael Forster

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Obesity : CK(11004) : AC(2672)

Therapeutic Actions : Dietary Modification: Caloric Restriction : CK(46) : AC(11)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Both chlorhexidine and turmeric can be used as an adjunct to mechanical means in preventing and treating gingivitis.

Pubmed Data : Complement Ther Clin Pract. 2016 Nov ;25:13-17. Epub 2016 Aug 2. PMID: 27863601

Article Published Date : Oct 31, 2016

Authors : Karissa A Stoyell, Jennifer L Mappus, Mona A Gandhi

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)

Diseases : Gingivitis : CK(628) : AC(90)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antimicrobial : CK(1577) : AC(790), Prophylactic Agents : CK(1700) : AC(335)

C. longa and B. serrata resin can relieve symptoms in patients with hand osteoarthritis.

Pubmed Data : Pharm Biol. 2022 Dec ;60(1):2295-2299. PMID: 36416059

Article Published Date : Nov 30, 2022

Authors : Yves Henrotin, Yvan Dierckxsens, Gaëlle Delisse, Nathalie Maes, Adelin Albert

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Frankincense : CK(1021) : AC(260)

Diseases : Adenoviridae Infections : CK(21) : AC(20), Coronavirus Infection : CK(3250) : AC(986), Inflammation : CK(16108) : AC(5498), Influenza : CK(1591) : AC(370), Rhinovirus Infection : CK(97) : AC(39), Upper Respiratory Infections : CK(1905) : AC(262)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Medication Reduction : CK(899) : AC(99), Plant Extracts : CK(18762) : AC(6782)

C. longa and B. serrata resulted to be promising agents for the management of inflammatory bowel diseases.

Pubmed Data : Pharmaceuticals (Basel). 2018 Nov 20 ;11(4). Epub 2018 Nov 20. PMID: 30463367

Article Published Date : Nov 19, 2018

Authors : Paolo Governa, Maddalena Marchi, Veronica Cocetta, Bianca De Leo, Philippa T K Saunders, Daniela Catanzaro, Elisabetta Miraldi, Monica Montopoli, Marco Biagi

Study Type : In Vitro Study

Additional Links

Substances : Frankincense : CK(1021) : AC(260), Turmeric : CK(9427) : AC(3904)

Diseases : Inflammatory Bowel Diseases : CK(3196) : AC(926)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Interleukin-6 Downregulation : CK(9337) : AC(3613), Interleukin-8 downregulation : CK(1107) : AC(402), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

C. longa and curcumin might decrease the risk of cancer and other malignant diseases in the reproductive system.

Pubmed Data : Endocr Regul. 2017 Oct 26 ;51(4):220-228. PMID: 29232190

Article Published Date : Oct 25, 2017

Authors : R Mohebbati, A Anaeigoudari, M R Khazdair

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)

Diseases : Ovarian Cancer : CK(1029) : AC(509), Prostate Cancer : CK(2805) : AC(1046), Testicular Cancer : CK(47) : AC(19)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Apoptotic : CK(9585) : AC(7379), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(1141) : AC(720), Prostaglandin PGE2 downregulation : CK(194) : AC(89), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806), Vascular Endothelial Growth Factor Inhibitors : CK(611) : AC(335)

C. longa is a safe and potent anti-inflammatory and antioxidant substance beneficial in the fight against IBD.

Pubmed Data : BMC Complement Altern Med. 2016 ;16(1):72. Epub 2016 Feb 23. PMID: 26907175

Article Published Date : Dec 31, 2015

Authors : Salim M A Bastaki, Mohammed Majed Al Ahmed, Ahmed Al Zaabi, Naheed Amir, Ernest Adeghate

Study Type : Animal Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Inflammatory Bowel Diseases : CK(3196) : AC(926), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Calebin A potentiates the effect of 5-FU and TNF-β against human colorectal cancer cells.

Pubmed Data : Int J Mol Sci. 2020 Mar 31 ;21(7). Epub 2020 Mar 31. PMID: 32244288

Article Published Date : Mar 30, 2020

Authors : Constanze Buhrmann, Ajaikumar B Kunnumakkara, Bastian Popper, Muhammed Majeed, Bharat B Aggarwal, Mehdi Shakibaei

Study Type : Human In Vitro

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Colorectal Cancer : CK(4889) : AC(2276)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Chemosensitizer : CK(1657) : AC(1270)

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil : CK(254) : AC(168)

Calebin A suppresses NF-κB regulated cell survival and inflammatory gene products leading to inhibition of cell growth and chemosensitization.

Pubmed Data : Phytomedicine. 2017 Oct 15 ;34:171-181. Epub 2017 Aug 31. PMID: 28899500

Article Published Date : Oct 14, 2017

Authors : Amit K Tyagi, Sahdeo Prasad, Muhammed Majeed, Bharat B Aggarwal

Study Type : In Vitro Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Cancers: All : CK(36404) : AC(14363)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antineoplastic Agents : CK(2235) : AC(1468), Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379), Cell cycle arrest : CK(2120) : AC(1715), Chemosensitizer : CK(1657) : AC(1270)

Calebin A, a compound of turmeric, down-regulates inflammation in tenocytes by NF-κB/Scleraxis signaling.

Pubmed Data : Int J Mol Sci. 2022 Feb 1 ;23(3). Epub 2022 Feb 1. PMID: 35163616

Article Published Date : Jan 31, 2022

Authors : Anna-Lena Mueller, Aranka Brockmueller, Ajaikumar B Kunnumakkara, Mehdi Shakibaei

Study Type : In Vitro Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Inflammation : CK(16108) : AC(5498), Tendinitis : CK(98) : AC(18)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Can an anti-inflammatory diet be effective in preventing or treating viral respiratory diseases?

Pubmed Data : Clin Nutr ESPEN. 2021 06 ;43:9-15. Epub 2021 Apr 24. PMID: 34024569

Article Published Date : Dec 31, 2020

Authors : Farhad Vahid, Diana Rahmani

Study Type : Review

Additional Links

Substances : Garlic : CK(2194) : AC(727), Ginger : CK(1593) : AC(479), Omega-3 Fatty Acids : CK(5655) : AC(768), Onion : CK(511) : AC(151), Saffron : CK(1324) : AC(285), Turmeric : CK(9427) : AC(3904), Vitamin C : CK(6066) : AC(1408), Vitamin D : CK(11762) : AC(1712), Zinc : CK(1957) : AC(345)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Cannabis and turmeric as complementary treatments for IBD and other digestive diseases.

Pubmed Data : Curr Gastroenterol Rep. 2019 Jan 11 ;21(2):2. Epub 2019 Jan 11. PMID: 30635796

Article Published Date : Jan 10, 2019

Authors : Sandra M Quezada, Raymond K Cross

Study Type : Review

Additional Links

Substances : Cannabis : CK(4705) : AC(1193), Turmeric : CK(9427) : AC(3904)

Diseases : Inflammatory Bowel Diseases : CK(3196) : AC(926)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Gastrointestinal Agents : CK(7657) : AC(2274)

Capsaicin, curcumin and cod liver reduce inflammation in rat peritoneal macrophages.

Pubmed Data : Biochim Biophys Acta. 1994 Nov 10;1224(2):255-63. PMID: 7981240

Article Published Date : Nov 10, 1994

Authors : B Joe, B R Lokesh

Study Type : In Vitro Study

Additional Links

Substances : Capsaicin : CK(338) : AC(129), Curcumin : CK(7239) : AC(3319), Omega-3 Fatty Acids : CK(5655) : AC(768)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Cellular and molecular mechanisms of curcumin on thyroid gland disorders.

Pubmed Data : Curr Med Chem. 2022 Feb 10. Epub 2022 Feb 10. PMID: 35142266

Article Published Date : Feb 09, 2022

Authors : Farzaneh Shakeri, Bahram Bibak, Mohammad Reza Safdari, Zakieh Keshavarzi, Tannaz Jamialahmadi, Thozhukat Sathyapalan, Amirhossein Sahebkar

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Hypothyroidism : CK(863) : AC(152), Thyroid Diseases : CK(348) : AC(52)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Cisplatin-induced LLC-PK1 renal cell damage was significantly reduced by tetrahydrocurcumin treatment.

Pubmed Data : Planta Med. 2015 Mar ;81(4):286-91. Epub 2015 Feb 26. PMID: 25719941

Article Published Date : Feb 28, 2015

Authors : Kyung Il Song, Jun Yeon Park, Seungyong Lee, Dahae Lee, Hyuk-Jai Jang, Su-Nam Kim, Hyeonseok Ko, Hyun Young Kim, Jae Wook Lee, Gwi Seo Hwang, Ki Sung Kang, Noriko Yamabe

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Tetrahydrocurcumin : CK(173) : AC(99)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1246) : AC(601), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Chemoprotective Agents : CK(4278) : AC(1621), Chemotherapeutic : CK(4390) : AC(1635), Renoprotective : CK(4544) : AC(1971)

Co-administration of iron and bioavailable curcumin reduces levels of systemic markers of inflammation and oxidative stress.

Pubmed Data : Nutrients. 2022 Feb 8 ;14(3). Epub 2022 Feb 8. PMID: 35277071

Article Published Date : Feb 07, 2022

Authors : Helena Tiekou Lorinczova, Gulshanara Begum, Lina Temouri, Derek Renshaw, Mohammed Gulrez Zariwala

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Iron : CK(134) : AC(16)

Diseases : Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Combination of curcumin and luteolin synergistically inhibits TNF-α-induced vascular inflammation in human vascular cells and mice.

Pubmed Data : J Nutr Biochem. 2019 Aug 15 ;73:108222. Epub 2019 Aug 15. PMID: 31665675

Article Published Date : Aug 14, 2019

Authors : Lijuan Zhang, Xiaoyong Wang, Longyun Zhang, Carlos Virgous, Hongwei Si

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Luteolin : CK(711) : AC(393)

Diseases : Cardiovascular Diseases : CK(17333) : AC(2878)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

Combination of curcumin and piperine synergistically improves pain-like behaviors in mouse models of pain.

Pubmed Data : Chin Med. 2022 Oct 23 ;17(1):119. Epub 2022 Oct 23. PMID: 36274168

Article Published Date : Oct 22, 2022

Authors : Pawana Boonrueng, Peththa Wadu Dasuni Wasana, Hasriadi, Opa Vajragupta, Pornchai Rojsitthisak, Pasarapa Towiwat

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Piperine : CK(600) : AC(258)

Diseases : Chronic Pain : CK(1524) : AC(284)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antinoceceptive : CK(959) : AC(291)

Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

Combination of lycopene and curcumin synergistically alleviates testosterone-propionate-induced benign prostatic hyperplasia.

Pubmed Data : Molecules. 2023 Jun 21 ;28(13). Epub 2023 Jun 21. PMID: 37446563

Article Published Date : Jun 20, 2023

Authors : Shanshan Wang, Wenjiang He, Wenzhi Li, Jin-Rong Zhou, Zhiyun Du

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Lycopene : CK(1267) : AC(372)

Diseases : Inflammation : CK(16108) : AC(5498), Prostatic Hyperplasia : CK(107) : AC(23)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Combination of α-tomatine and curcumin more potently inhibited the growth of PC-3 tumors than either agent alone.

Pubmed Data : PLoS One. 2015;10(12):e0144293. Epub 2015 Dec 2. PMID: 26630272

Article Published Date : Dec 31, 2014

Authors : Huarong Huang, Xuan Chen, Dongli Li, Yan He, Yu Li, Zhiyun Du, Kun Zhang, Robert DiPaola, Susan Goodin, Xi Zheng

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Tomato : CK(1710) : AC(438)

Diseases : Prostate Cancer : CK(2805) : AC(1046)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379), Bcl-2 protein down-regulation : CK(711) : AC(529), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

Combination treatment of dendrosomal nanocurcumin and low-level laser therapy develops proliferation and migration of mouse embryonic fibroblasts.

Pubmed Data : PLoS One. 2021 ;16(5):e0247098. Epub 2021 May 6. PMID: 33956815

Article Published Date : Dec 31, 2020

Authors : Afsaneh Ebrahiminaseri, Majid Sadeghizadeh, Ahmad Moshaii, Golareh Asgaritarghi, Zohreh Safari

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Therapeutic Actions : Photobiomodulation : CK(17459) : AC(3331)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613), Proliferative : CK(162) : AC(98), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Combined effect of exercise and curcumin on inflammation-associated microRNAs and cytokines in old male rats.

Pubmed Data : Heliyon. 2025 Jan 30 ;11(2):e41895. Epub 2025 Jan 11. PMID: 39897895

Article Published Date : Jan 29, 2025

Authors : Zahra Shargh, Keyvan Asghari, Morteza Asghariehahari, Leila Chodari

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Combined treatment of curcumin with low doses of prednisolone may find therapeutic use in arthritis.

Pubmed Data : J Pharm Pharmacol. 2014 Jan ;66(1):133-44. Epub 2013 Oct 21. PMID: 24138213

Article Published Date : Dec 31, 2013

Authors : Madhusudana Kuncha, Vegi Ganga Modi Naidu, Bidya Dhar Sahu, Shankar Ganesh Gadepalli, Ramakrishna Sistla

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Arthritis : CK(5826) : AC(1505)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Additional Keywords : Natural Substance/Drug Synergy : CK(1526) : AC(720), Plant Extracts : CK(18762) : AC(6782)

Combining nano-curcumin with catechin improves COVID-19-infected patient's inflammatory conditions.

Pubmed Data : Hum Immunol. 2023 Sep ;84(9):471-483. Epub 2023 Jun 5. PMID: 37331910

Article Published Date : Aug 31, 2023

Authors : Talar Ahmad Merza Mohammad

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Coronavirus Disease (Covid-19) : CK(1328) : AC(329)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-17 downregulation : CK(502) : AC(192)

Comparation of anti-inflammatory and antioxidantactivities of curcumin, tetrahydrocurcuminand octahydrocurcuminin LPS-stimulated RAW264.7 macrophages.

Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:8856135. Epub 2020 Dec 22. PMID: 33424997

Article Published Date : Dec 31, 2019

Authors : Qing-Feng Xie, Juan-Juan Cheng, Jin-Fen Chen, Yu-Chao Feng, Guo-Shu Lin, Yang Xu

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Curcuminoids : CK(7851) : AC(3498), Tetrahydrocurcumin : CK(173) : AC(99)

Diseases : Inflammation : CK(16108) : AC(5498), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Nrf2 activation : CK(3156) : AC(1794)

Comparison of the protective effects of curcumin and caffeic acid phenethyl ester against doxorubicin-induced testicular toxicity.

Pubmed Data : Andrologia. 2020 Dec 1:e13919. Epub 2020 Dec 1. PMID: 33289171

Article Published Date : Nov 30, 2020

Authors : Zübeyir Huyut, Hamit Hakan Alp, Turan Yaman, Ömer Faruk Keleş, Zabit Yener, Fikret Türkan, Kemal Ayengin

Study Type : Animal Study

Additional Links

Substances : Caffeic acid phenethyl ester : CK(284) : AC(172), Curcumin : CK(7239) : AC(3319)

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(845) : AC(423), Testicular Injury: Chemical/Metal Induced : CK(774) : AC(385)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Chemoprotective Agents : CK(4278) : AC(1621)

Compounds from turmeric showed potent inhibitory activity against nitric oxide production.

Pubmed Data : Nat Prod Res. 2017 Jul 20:1-6. Epub 2017 Jul 20. PMID: 28726500

Article Published Date : Jul 19, 2017

Authors : Ting Yuan, Cuiyun Zhang, Chongyue Qiu, Guiyang Xia, Fei Wang, Bin Lin, Hua Li, Lixia Chen

Study Type : In Vitro Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Nitric Oxide Inhibitor : CK(705) : AC(356)

Comprehensive insights into pathophysiology of Alzheimer's disease: herbal approaches for mitigating neurodegeneration.

Pubmed Data : Curr Alzheimer Res. 2024 Apr 15. Epub 2024 Apr 15. PMID: 38623983

Article Published Date : Apr 14, 2024

Authors : Debasis Sen, Sunny Rathee, Vishal Pandey, Sanjay K Jain, Umesh K Patil

Study Type : Review

Additional Links

Substances : Omega 3 Fatty Acids : CK(1469) : AC(261), Pomegranate : CK(1800) : AC(573), Resveratrol : CK(3228) : AC(1513), Skullcap: Chinese : CK(174) : AC(98), Turmeric : CK(9427) : AC(3904)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Coupling to a cancer cell-specific antibody potentiates tumoricidal properties of curcumin.

Pubmed Data : Int J Cancer. 2012 Aug 15 ;131(4):E569-78. Epub 2012 Jan 3. PMID: 21989768

Article Published Date : Aug 14, 2012

Authors : Phyllis Langone, Priya Ranjan Debata, Sukanta Dolai, Gina Marie Curcio, Joseph Del Rosario Inigo, Krishnaswami Raja, Probal Banerjee

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Melanoma : CK(924) : AC(552)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

COX2 expression in HPV16-induced lesions may be modulated by nutraceuticals.

Pubmed Data : Anticancer Res. 2018 03 ;38(3):1461-1466. PMID: 29491072

Article Published Date : Dec 31, 2017

Authors : Magda S S Moutinho, Sofia Aragão, Diogo Carmo, Fátima Casaca, Sandra Silva, Joana Ribeiro, Hugo Sousa, Isabel Pires, Felisbina Queiroga, Bruno Colaço, Rui Medeiros, Paula A Oliveira, Carlos Lopes, Margarida M S M Bastos, Rui M Gil DA Costa

Study Type : Transgenic Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Rutin : CK(463) : AC(223)

Diseases : Human Papillomavirus (HPV) : CK(397) : AC(85), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Chemopreventive : CK(6580) : AC(2166), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327)

Crocin and curcumin, either alone or in combination, can be a suitable treatment modality for rheumatoid arthritis.

Pubmed Data : Curr Med Chem. 2023 Apr 8. Epub 2023 Apr 8. PMID: 37031388

Article Published Date : Apr 07, 2023

Authors : Khodabakhsh Rashidi, Mitra Korani, Houshang Nemati, Raheleh Shahraki, Shahla Korani, Mitra Abbasifard, Muhammed Majeed, Tannaz Jamialahmadi, Amirhossein Sahebkar

Study Type : Animal Study

Additional Links

Substances : Crocin : CK(732) : AC(311), Curcumin : CK(7239) : AC(3319)

Diseases : Rheumatoid Arthritis : CK(2322) : AC(562)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Crude turmeric extract improves the suppressive effects of Lactobacillus rhamnosus GG on allergic inflammation.

Pubmed Data : Front Immunol. 2020 ;11:1092. Epub 2020 Jun 4. PMID: 32582180

Article Published Date : Dec 31, 2019

Authors : Fariba Ghiamati Yazdi, Amin Zakeri, Ingrid van Ark, Thea Leusink-Muis, Saskia Braber, Sabihe Soleimanian-Zad, Gert Folkerts

Study Type : In Vitro Study

Additional Links

Substances : Lactobacillus rhamnosus GG : CK(660) : AC(147), Turmeric : CK(9427) : AC(3904)

Diseases : Asthma : CK(3242) : AC(707)

Pharmacological Actions : Anti-Asthmatic Agents : CK(510) : AC(148), Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

Curcuma and karkade could ameliorate the immunological disturbances caused by repeated exposure to the house dust mite’s faeces.

Pubmed Data : Allergol Immunopathol (Madr). 2015 May 13. Epub 2015 May 13. PMID: 25982575

Article Published Date : May 12, 2015

Authors : Bahaa K A Abdel-Salam, Nagiba I A Shoker, Ahmed M R Mohamad

Study Type : Animal Study

Additional Links

Substances : Hibiscus : CK(73) : AC(39), Turmeric : CK(9427) : AC(3904)

Diseases : Allergic Airway Diseases : CK(80) : AC(32)

Pharmacological Actions : Anti-Allergic Agents : CK(598) : AC(221), Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcuma aromatica protects from acetaminophen-induced hepatotoxicity.

Pubmed Data : Nutrients. 2023 Feb 4 ;15(4). Epub 2023 Feb 4. PMID: 36839166

Article Published Date : Feb 03, 2023

Authors : Hyunseong Kim, Jinyoung Hong, Junseon Lee, Wanjin Jeon, Changhwan Yeo, Yoonjae Lee, Seungho Baek, Inhyuk Ha

Study Type : In Vitro Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Heme oxygenase-1 up-regulation : CK(1336) : AC(776), Interleukin-10 upregulation : CK(1296) : AC(436), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Problem Substances : Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806), Paracetamol : CK(863) : AC(298)

Curcuma as an anti-inflammatory component in treating osteoarthritis.

Pubmed Data : Rheumatol Int. 2022 Nov 17. Epub 2022 Nov 17. PMID: 36394597

Article Published Date : Nov 16, 2022

Authors : Zrinka Djukić Koroljević, Katarina Jordan, Jakov Ivković, Darija Vranešić Bender, Porin Perić

Study Type : Review

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Osteoprotective : CK(2037) : AC(685)

Curcuma longa and Boswellia serrata extracts modulate different and complementary pathways on human chondrocytes.

Pubmed Data : Front Pharmacol. 2022 ;13:931914. Epub 2022 Aug 11. PMID: 36034822

Article Published Date : Dec 31, 2021

Authors : Christelle Sanchez, Jérémie Zappia, Cécile Lambert, Jacques Foguenne, Yvan Dierckxsens, Jean-Emile Dubuc, Jean-Pierre Delcour, André Gothot, Yves Henrotin

Study Type : In Vitro Study

Additional Links

Substances : Frankincense : CK(1021) : AC(260), Turmeric : CK(9427) : AC(3904)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Chondroprotective : CK(226) : AC(116)

Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight.

Pubmed Data : Nutr J. 2021 11 13 ;20(1):91. Epub 2021 Nov 13. PMID: 34774052

Article Published Date : Jan 12, 2021

Authors : Ryusei Uchio, Kengo Kawasaki, Chinatsu Okuda-Hanafusa, Ryosuke Saji, Koutarou Muroyama, Shinji Murosaki, Yoshihiro Yamamoto, Yoshitaka Hirose

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)

Diseases : Inflammation : CK(16108) : AC(5498), Overweight : CK(12956) : AC(2796)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Curcuma longa has chemical compounds targeting the histamine H4 receptor.

Pubmed Data : Inflamm Res. 2017 Jun 24. Epub 2017 Jun 24. PMID: 28647836

Article Published Date : Jun 23, 2017

Authors : Annika Frank, Saleh Abu-Lafi, Azmi Adawi, Johannes S Schwed, Holger Stark, Anwar Rayan

Study Type : In Vitro Study

Additional Links

Substances : Demethoxycurcumin : CK(80) : AC(53), Turmeric : CK(9427) : AC(3904)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcuma longa L. effects on Akt/mTOR pathway and NF-κB expression during skin wound healing.

Pubmed Data : Appl Immunohistochem Mol Morphol. 2021 Jul 14. Epub 2021 Jul 14. PMID: 34261975

Article Published Date : Jul 13, 2021

Authors : Chris K Danilevicz, Vivian P Wagner, Nilson Ferreira, Hugo Bock, Emily F Salles Pilar, Liana P Webber, Tuany R Schmidt, Ellen C P Alonso, Elismauro F de Mendonça, Marize C Valadares, Ricardo N Marreto, Manoela D Martins

Study Type : In Vitro Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcuma longa L. extract improves the cortical neural connectivity during the aging process.

Pubmed Data : Neural Regen Res. 2017 Jun ;12(6):875-880. PMID: 28761413

Article Published Date : May 31, 2017

Authors : Gonzalo Flores

Study Type : Review

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Aging: Brain : CK(1118) : AC(268)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Curcuma longa L. extract supplementation leads to an increase in IL-10 and decreased myoglobin in recreational male runners after a half-marathon race.

Pubmed Data : Eur J Appl Physiol. 2020 Jul ;120(7):1531-1540. Epub 2020 May 2. PMID: 32361773

Article Published Date : Jun 30, 2020

Authors : Flávia Rasmussen Faria, Aline Corado Gomes, Alisson Antunes, Kênnia Rocha Rezende, Gustavo Duarte Pimentel, Camila Lemos Pinto Oliveira, Barbara Moura Antunes, Fabio Santos Lira, Marcelo Saldanha Aoki, João Felipe Mota

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)

Diseases : Inflammation : CK(16108) : AC(5498), Muscle Damage: Exercise-Induced : CK(1101) : AC(137)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-10 upregulation : CK(1296) : AC(436)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Curcuma longa polyphenols protect adipose cells against oxidative stress and may improve obesity-related metabolic disorders.

Pubmed Data : Biofactors. 2016 Apr 20. Epub 2016 Apr 20. PMID: 27094023

Article Published Date : Apr 19, 2016

Authors : Axelle Septembre-Malaterre, Fanny Le Sage, Sarah Hatia, Aurélie Catan, Laurent Janci, Marie-Paule Gonthier

Study Type : In Vitro Study

Additional Links

Substances : Curcuminoids : CK(7851) : AC(3498), Turmeric : CK(9427) : AC(3904)

Diseases : Obesity : CK(11004) : AC(2672)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcuma longa supplementation helps prevent osteoarthritis development and is an effective therapy for osteoarthritis.

Pubmed Data : Food Nutr Res. 2024 ;68. Epub 2024 Mar 19. PMID: 38571919

Article Published Date : Dec 31, 2023

Authors : Hyelim Kim, Jaeeun Jung, Minhee Lee, Minha Kim, Namgil Kang, Ok-Kyung Kim, Jeongmin Lee

Study Type : Animal Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Osteoprotective : CK(2037) : AC(685), Postaglandin PGE2 downregulation : CK(386) : AC(199)

Additional Keywords : Risk Reduction : CK(17935) : AC(2006)

Curcuma longa supplementation reduces MDA, TNF-α, and IL-6 levels in a rat model exposed to soot particulates.

Pubmed Data : Open Vet J. 2023 Jan ;13(1):11-19. Epub 2023 Jan 5. PMID: 36777433

Article Published Date : Dec 31, 2022

Authors : Muhammad Aminuddin, Djanggan Sargowo, Teguh Wahju Sardjono, Widjiati Widjiati

Study Type : Animal Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Air Pollution Linked Toxicity : CK(4976) : AC(742), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613), Malondialdehyde Down-regulation : CK(3028) : AC(992), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumenol improves renal function in 5/6 nephrectomy-induced chronic renal failure.

Pubmed Data : Anat Rec (Hoboken). 2023 Dec ;306(12):3189-3198. Epub 2022 Dec 10. PMID: 36495299

Article Published Date : Nov 30, 2023

Authors : Guanghui Zhong, Xudong Cai, Renxiong Wei, Sheng Wei, Xiaodan Cao

Study Type : Animal Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Kidney Failure: Chronic : CK(342) : AC(51)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464), Renoprotective : CK(4544) : AC(1971)

Curcumenol mitigates chondrocyte inflammation.

Pubmed Data : Int J Mol Med. 2021 Oct ;48(4). Epub 2021 Aug 26. PMID: 34435650

Article Published Date : Sep 30, 2021

Authors : Xiao Yang, Yifan Zhou, Zhiqian Chen, Chen Chen, Chen Han, Xunlin Li, Haijun Tian, Xiaofei Cheng, Kai Zhang, Tangjun Zhou, Jie Zhao

Study Type : Animal Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Inflammation : CK(16108) : AC(5498), Osteoarthritis : CK(2225) : AC(627)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), NF-kappaB Inhibitor : CK(5952) : AC(3464), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumenol mitigates the inflammation and ameliorates the catabolism status of the intervertebral discs.

Pubmed Data : Front Pharmacol. 2022 ;13:905966. Epub 2022 Jun 20. PMID: 35795557

Article Published Date : Dec 31, 2021

Authors : Xiao Yang, Baixing Li, Haijun Tian, Xiaofei Cheng, Tangjun Zhou, Jie Zhao

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Low Back Pain : CK(1467) : AC(153)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin (a constituent of turmeric): New treatment option against COVID-19.

Pubmed Data : Food Sci Nutr. 2020 Oct ;8(10):5215-5227. Epub 2020 Sep 6. PMID: 33133525

Article Published Date : Sep 30, 2020

Authors : Fatemeh Babaei, Marjan Nassiri-Asl, Hossein Hosseinzadeh

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Coronavirus Infection : CK(3250) : AC(986)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin (from Turmeric) has has neuroprotective properties mostly due to its anti-inflammatory effects.

Pubmed Data : Pharmazie. 2007 Dec;62(12):937-42. PMID: 18214347

Article Published Date : Dec 01, 2007

Authors : Hae Sung Lee, Ki Kyung Jung, Jae Youl Cho, Man Hee Rhee, Sungyoul Hong, Moosik Kwon, Seung Hee Kim, Seog Youn Kang

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain Diseases : CK(21) : AC(10)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin (Turmeric) may benefit Multiple Sclerosis by blocking an inflammatory mediator.

Pubmed Data : J Immunol. 2002 Jun 15;168(12):6506-13. PMID: 12055272

Article Published Date : Jun 15, 2002

Authors : Chandramohan Natarajan, John J Bright

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Multiple Sclerosis : CK(2432) : AC(557)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin administered through nasal route might prove therapeutically efficient in inhibiting allergic airway inflammation.

Pubmed Data : Allergol Immunopathol (Madr). 2016 Apr 1. Epub 2016 Apr 1. PMID: 27046748

Article Published Date : Mar 31, 2016

Authors : Subhashini, P S Chauhan, R Singh

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Allergic Airway Diseases : CK(80) : AC(32), Asthma : CK(3242) : AC(707)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin administration can limit the poisonous impacts of deltamethrin.

Pubmed Data : J Biochem Mol Toxicol. 2019 Oct ;33(10):e22386. Epub 2019 Aug 27. PMID: 31454128

Article Published Date : Sep 30, 2019

Authors : Wenbin Shi, Daisong Zhang, Lei Wang, Nagaraja Sreeharsha, Yushan Ning

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Pyrethroid Insecticide Induced Toxicity : CK(24) : AC(12)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Heme oxygenase-1 up-regulation : CK(1336) : AC(776), Nrf2 activation : CK(3156) : AC(1794), Renoprotective : CK(4544) : AC(1971)

Problem Substances : Deltamethrin : CK(45) : AC(21)

Curcumin administration could be used as supplementary therapeutic intervention at early stage of endotoxemia.

Pubmed Data : Inflammopharmacology. 2017 Mar 13. Epub 2017 Mar 13. PMID: 28289922

Article Published Date : Mar 12, 2017

Authors : Asha Kumari, D Dash, Rashmi Singh

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Endotoxemia : CK(359) : AC(127), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin alleviated lipopolysaccharide-evoked H9c2 cells damage.

Pubmed Data : Hum Exp Toxicol. 2022 Jan-Dec;41:9603271211069043. PMID: 35549587

Article Published Date : Dec 31, 2021

Authors : Yi Liu, Xiaoli Li, Yan Zhao

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin alleviated lung edema in lipopolysaccharide induced acute lung injury by inhibiting inflammation.

Pubmed Data : Med Sci Monit. 2018 Feb 26 ;24:1178-1184. Epub 2018 Feb 26. PMID: 29480285

Article Published Date : Feb 25, 2018

Authors : Keping Cheng, Aijuan Yang, Xiaohui Hu, Dongbo Zhu, Kaizhong Liu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875), Lung Injury: Acute : CK(533) : AC(253)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin alleviates hepatic ischemia-reperfusion injury.

Pubmed Data : J Invest Surg. 2023 Dec ;36(1):2164813. PMID: 36603844

Article Published Date : Nov 30, 2023

Authors : Cunle Zhu, Shangheng Shi, Peng Jiang, Xijian Huang, Jinxin Zhao, Yan Jin, Yuntai Shen, Xin Zhou, Huan Liu, Jinzhen Cai

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Inflammation : CK(16108) : AC(5498), Liver Damage : CK(4109) : AC(1872), Liver Injury: Ischemia/reperfusion : CK(175) : AC(95)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831)

Curcumin alleviates high-fat diet-induced nonalcoholic steatohepatitis.

Pubmed Data : J Agric Food Chem. 2023 Jul 12 ;71(27):10338-10348. Epub 2023 Jun 30. PMID: 37389466

Article Published Date : Jul 11, 2023

Authors : Jiazhen Wu, Mengyao Li, Ning Huang, Fengkun Guan, Huijuan Luo, Liping Chen, Guilan Wei, Muxia Li, Zhixiu Lin, Ziren Su, Jiannan Chen, Yuhong Liu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : High Fat Diet : CK(2040) : AC(984), Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hypolipidemic : CK(9173) : AC(2038), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin alleviates macrophage activation and lung inflammation induced by influenza virus infection.

Pubmed Data : Influenza Other Respir Viruses. 2017 09 ;11(5):457-463. Epub 2017 Jul 11. PMID: 28646616

Article Published Date : Dec 31, 2016

Authors : Yiming Xu, Ling Liu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Influenza : CK(1591) : AC(370), Lung Inflammation : CK(276) : AC(113)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin alleviates matrix metalloproteinases associated with inflammation during eradication of H. pylori infection.

Pubmed Data : PLoS One. 2011;6(1):e16306. Epub 2011 Jan 21. PMID: 21283694

Article Published Date : Jan 01, 2011

Authors : Parag Kundu, Ronita De, Ipsita Pal, Asish K Mukhopadhyay, Dhira Rani Saha, Snehasikta Swarnakar

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Helicobacter Pylori Infection : CK(1213) : AC(275)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Matrix metalloproteinase-3 (MMP-3) inhibitor : CK(238) : AC(107), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(1141) : AC(720)

Curcumin alone or in combination with clarithromycin showed a much more significant reduction in neutrophil influx along with reduced levels of various inflammatory parameters.

Pubmed Data : J Infect Dev Ctries. 2014 Jul ;8(7):838-44. Epub 2014 Jul 14. PMID: 25022293

Article Published Date : Jun 30, 2014

Authors : Shruti Bansal, Sanjay Chhibber

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Klebsiella Infections : CK(217) : AC(128), Klesiella Pneumonia Infection : CK(7) : AC(5)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360)

Curcumin ameliorated skeletal muscle atrophy in DM mice by inhibiting protein ubiquitination, inflammatory cytokines and oxidative stress.

Pubmed Data : Exp Physiol. 2015 May 22. Epub 2015 May 22. PMID: 25998196

Article Published Date : May 21, 2015

Authors : Taisuke Ono, Shingo Takada, Shintaro Kinugawa, Tadashi Suga, Mochamad A Sobirin, Kagami Hirabayashi, Masashige Takahashi, Arata Fukushima, Tsuneaki Homma, Takashi Yokota, Shouji Matsushima, Hiroyuki Tsutsui

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Diabetes: Oxidative Stress : CK(635) : AC(244), Diabetes Mellitus: Type 1 : CK(2032) : AC(611), Inflammation : CK(16108) : AC(5498), Muscle Atrophy : CK(292) : AC(124)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), NF-kappaB Inhibitor : CK(5952) : AC(3464), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Additional Keywords : Significant Treatment Outcome : CK(4297) : AC(505)

Curcumin ameliorates acute myocarditis in rats and encouraged the estimation of serum level of TRX as a relevant indicator for the evaluation of the progress of acute myocarditis.

Pubmed Data : Folia Morphol (Warsz). 2015;74(3):318-324. PMID: 26339812

Article Published Date : Dec 31, 2014

Authors : A M Ahmed, A F El Fouhil, R A Mohamed, M Atteya, N A Abdel-Baky, A H AlRoalle, A M Aldahmash

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Inflammation : CK(16108) : AC(5498), Myocarditis : CK(284) : AC(45)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Cardioprotective : CK(9504) : AC(2963), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin ameliorates asthmatic airway inflammation.

Pubmed Data : Clin Exp Pharmacol Physiol. 2015 May ;42(5):520-9. PMID: 25739561

Article Published Date : Apr 30, 2015

Authors : Liyun Liu, Yunxiao Shang, Miao Li, Xiaohua Han, Jia Wang, Juan Wang

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Asthma : CK(3242) : AC(707), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Heme oxygenase-1 up-regulation : CK(1336) : AC(776), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Nrf2 activation : CK(3156) : AC(1794)

Curcumin ameliorates doxorubicin-induced cardiotoxicity.

Pubmed Data : J Biochem Mol Toxicol. 2018 Feb ;32(2). Epub 2018 Jan 5. PMID: 29315967

Article Published Date : Jan 31, 2018

Authors : Fulya Benzer, Fatih Mehmet Kandemir, Mustafa Ozkaraca, Sefa Kucukler, Cuneyt Caglayan

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(845) : AC(423)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Chemoprotective Agents : CK(4278) : AC(1621), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327)

Curcumin ameliorates H2O2-induced inflammatory response in chondrocytes by inducing autophagy activation.

Pubmed Data : Exp Ther Med. 2022 Apr ;23(4):272. Epub 2022 Feb 9. PMID: 35251338

Article Published Date : Mar 31, 2022

Authors : Hai-Liang Qi, Zheng-Yi Chen, Yu-Huan Qin, Ya-Zhai Li

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Hydrogen Peroxide Induced Toxicity : CK(437) : AC(349), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Autophagy Up-regulation : CK(838) : AC(559)

Curcumin ameliorates hypertension via gut-brain communication in spontaneously hypertensive rat.

Pubmed Data : Toxicol Appl Pharmacol. 2021 Oct 15 ;429:115701. Epub 2021 Aug 25. PMID: 34453990

Article Published Date : Oct 14, 2021

Authors : Hong-Bao Li, Meng-Lu Xu, Meng-Meng Du, Xiao-Jing Yu, Juan Bai, Wen-Jie Xia, Zhi-Ming Dai, Chang-Xing Li, Ying Li, Qing Su, Xiao-Min Wang, Yuan-Yuan Dong, Yu-Ming Kang

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain Inflammation : CK(1784) : AC(928), Hypertension : CK(9125) : AC(1361)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Additional Keywords : Gut-brain Axis : CK(686) : AC(289)

Curcumin ameliorates lead-induced hepatotoxicity.

Pubmed Data : Biomolecules. 2019 Nov 5 ;9(11). Epub 2019 Nov 5. PMID: 31694300

Article Published Date : Nov 04, 2019

Authors : Ahlam Alhusaini, Laila Fadda, Iman H Hasan, Enas Zakaria, Abeer M Alenazi, Ayman M Mahmoud

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Problem Substances : Lead : CK(700) : AC(231)

Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production.

Pubmed Data : Clin Exp Pharmacol Physiol. 2018 Jan ;45(1):84-93. Epub 2017 Oct 3. PMID: 28853207

Article Published Date : Dec 31, 2017

Authors : Shuguang Han, Jing Xu, Xiangjun Guo, Mao Huang

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Influenza A : CK(582) : AC(204), Pneumonia : CK(1101) : AC(171)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Heme oxygenase-1 up-regulation : CK(1336) : AC(776), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin ameliorates white matter injury after ischemic stroke.

Pubmed Data : Oxid Med Cell Longev. 2021 ;2021:1552127. Epub 2021 Sep 30. PMID: 34630845

Article Published Date : Dec 31, 2020

Authors : Yuanyuan Ran, Wei Su, Fuhai Gao, Zitong Ding, Shuiqing Yang, Lin Ye, Xuechai Chen, Guiqin Tian, Jianing Xi, Zongjian Liu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)

Diseases : Brain Ischemia : CK(582) : AC(255), Stroke: Ischemic : CK(1030) : AC(284)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Additional Keywords : Phytotherapy : CK(4003) : AC(1031), Plant Extracts : CK(18762) : AC(6782)

Curcumin ameliorative effects against AP through induction of apoptosis and inhibition of micro-thrombosis, inflammation, and oxidative stress.

Pubmed Data : J Biochem Mol Toxicol. 2016 Feb 10. Epub 2016 Feb 10. PMID: 26862043

Article Published Date : Feb 09, 2016

Authors : Noha M Shafik, Ghada M Abou-Fard

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Pancreatitis : CK(500) : AC(186)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin amends Ca2+ dysregulation in microglia by suppressing the activation of P2X7 receptor.

Pubmed Data : Mol Cell Biochem. 2020 Feb ;465(1-2):65-73. Epub 2020 Jan 1. PMID: 31894530

Article Published Date : Jan 31, 2020

Authors : Zhen Wang, Weihua Ren, Fucheng Zhao, Yanru Han, Caili Liu, Kui Jia

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Depression : CK(9574) : AC(1756), Stroke: Attenuation/Recovery : CK(998) : AC(156)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antidepressive Agents : CK(7908) : AC(1466)

Curcumin and Apigenin might delay the onset of Alzheimer's disease or slow down its progression.

Pubmed Data : Neural Regen Res. 2015 Aug ;10(8):1181-5. PMID: 26487830

Article Published Date : Jul 31, 2015

Authors : Madhuri Venigalla, Erika Gyengesi, Gerald Münch

Study Type : Review

Additional Links

Substances : Apigenin : CK(681) : AC(392), Curcumin : CK(7239) : AC(3319)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210), Brain Inflammation : CK(1784) : AC(928)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin and berberine arrest maturation and activation of dendritic cells derived from Lupus erythematosus patients.

Pubmed Data : Curr Mol Pharmacol. 2024 Jan 26. Epub 2024 Jan 26. PMID: 38284733

Article Published Date : Jan 25, 2024

Authors : Amin Reza Nikpoor, Mahmoud Mahmoudi, Abbas Shapouri-Moghaddam, Zahra Rezaieyazdi, Samaneh Mollazadeh, Nafiseh Tabasi, Atena Mansouri, Reyhane Modarres Moghadam, Amir Abbas Momtazi, Soran K Najmaldin, Ramiar Kamal Kheder, Seyed-Alireza Esmaeili

Study Type : Human In Vitro

Additional Links

Substances : Berberine : CK(2483) : AC(1079), Curcumin : CK(7239) : AC(3319)

Diseases : Systemic Lupus Erythematosus : CK(817) : AC(139)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360)

Curcumin and Boswellia serrata are safe and tolerable and helped to improvethe levels of an inflammatory cytokine (IL-6).

Pubmed Data : J Complement Integr Med. 2013 ;10(1):1-10. Epub 2013 Jul 1. PMID: 23828329

Article Published Date : Dec 31, 2012

Authors : Rodney G Bowden, Jennifer J Moreillon, Erika Deike, Jackson Griggs, Ron Wilson, Brian Shelmadine, Matt Cooke, Alexander Beaujean

Study Type : Human Study

Additional Links

Substances : Boswellia : CK(123) : AC(30), Turmeric : CK(9427) : AC(3904)

Diseases : Chronic Kidney Disease (CKD) : CK(1186) : AC(211)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613)

Additional Keywords : Substance Combination : CK(20) : AC(2)

Curcumin and capsaicin regulate apoptosis and alleviate intestinal inflammation induced by Clostridioides difficile.

Pubmed Data : Ann Clin Microbiol Antimicrob. 2022 Sep 26 ;21(1):41. Epub 2022 Sep 26. PMID: 36155114

Article Published Date : Sep 25, 2022

Authors : Masoumeh Azimirad, Maryam Noori, Fahimeh Azimirad, Fatemeh Gholami, Kaveh Naseri, Abbas Yadegar, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali

Study Type : In Vitro Study

Additional Links

Substances : Capsaicin : CK(338) : AC(129), Curcumin : CK(7239) : AC(3319)

Diseases : Clostridium Infections : CK(455) : AC(100), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Bcl-2 protein down-regulation : CK(711) : AC(529), NF-kappaB Inhibitor : CK(5952) : AC(3464), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin and capsaicin treatments attenuated hepatic fat accumulation and increased leptin levels related to inflammation.

Pubmed Data : Arch Physiol Biochem. 2015 Dec 26:1-29. Epub 2015 Dec 26. PMID: 26706937

Article Published Date : Dec 25, 2015

Authors : Muhammed Seyithanoğlu, Yıldız Öner-İyidoğan, Semra Doğru-Abbasoğlu, Sevda Tanrıkulu-Küçük, Hikmet Koçak, Şule Beyhan-Özdaş, Necla Koçak-Toker

Study Type : Animal Study

Additional Links

Substances : Capsaicin : CK(338) : AC(129), Curcumin : CK(7239) : AC(3319)

Diseases : High Fat Diet : CK(2040) : AC(984)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831)

Curcumin and CoQ10 independently as well as in combination ameliorate chronic hyperalgesia in sickle mice.

Pubmed Data : Haematologica. 2015 Nov 6. Epub 2015 Nov 6. PMID: 26546503

Article Published Date : Nov 05, 2015

Authors : Yessenia Valverde, Barbara Benson, Mihir Gupta, Kalpna Gupta

Study Type : Transgenic Animal Study

Additional Links

Substances : Coenzyme Q10 : CK(2359) : AC(412), Curcumin : CK(7239) : AC(3319)

Diseases : Brain: Microglial Activation : CK(205) : AC(118), Hyperalgesia : CK(339) : AC(152), Sickle Cell Anemia : CK(244) : AC(31)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin and Curcuma longa extract may improve symptoms and inflammation levels in people with arthritis.

Pubmed Data : Front Immunol. 2022 ;13:891822. Epub 2022 Jul 22. PMID: 35935936

Article Published Date : Dec 31, 2021

Authors : Liuting Zeng, Tiejun Yang, Kailin Yang, Ganpeng Yu, Jun Li, Wang Xiang, Hua Chen

Study Type : Meta Analysis, Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)

Diseases : Inflammation : CK(16108) : AC(5498), Rheumatoid Arthritis : CK(2322) : AC(562), Spondylitis: Ankylosing : CK(299) : AC(33)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin and gallic acid have a protective role in advanced glycation end products induces systemic inflammation and weight gain.

Pubmed Data : Food Chem Toxicol. 2018 Feb 9. Epub 2018 Feb 9. PMID: 29432842

Article Published Date : Feb 08, 2018

Authors : Boopathi Sowndhar Rajan, Senthamizharasi Manivasagam, Suresh Dhanusu, Navvi Chandrasekar, Kalaiselvi Krishna, Lakshmi Priya Kalaiarasu, Aadhil Ashwaq Babu, Elangovan Vellaichamy

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Gallic Acid : CK(341) : AC(212)

Diseases : Advanced Glycation End products (AGE) : CK(589) : AC(249), Obesity : CK(11004) : AC(2672)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anti-Inflammatory Agents : CK(39737) : AC(15858), CURCUMIN : CK(25) : AC(18), CURCUMIN : CK(25) : AC(18), CURCUMIN : CK(25) : AC(18)

Curcumin and inflammatory bowel diseases: From in vitro studies to clinical trials.

Pubmed Data : Mol Immunol. 2021 Feb ;130:20-30. Epub 2020 Dec 19. PMID: 33348246

Article Published Date : Jan 31, 2021

Authors : Farzaneh Fallahi, Sarina Borran, Milad Ashrafizadeh, Ali Zarrabi, Mohammad Hossein Pourhanifeh, Mahmood Khaksary Mahabady, Amirhossein Sahebkar, Hamed Mirzaei

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Inflammatory Bowel Diseases : CK(3196) : AC(926)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Gastrointestinal Agents : CK(7657) : AC(2274)

Curcumin and intestinal inflammatory diseases: molecular mechanisms of protection.

Pubmed Data : Int J Mol Sci. 2019 Apr 18 ;20(8). Epub 2019 Apr 18. PMID: 31003422

Article Published Date : Apr 17, 2019

Authors : Kathryn Burge, Aarthi Gunasekaran, Jeffrey Eckert, Hala Chaaban

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Crohn's Disease : CK(242) : AC(55), Inflammation : CK(16108) : AC(5498), Ulcerative Colitis : CK(1411) : AC(447)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antimicrobial : CK(1577) : AC(790), Immunomodulatory : CK(6531) : AC(2360)

Curcumin and its derivatives as potential antimalarial and anti-inflammatory agents.

Pubmed Data : Pharmaceuticals (Basel). 2023 Apr 18 ;16(4). Epub 2023 Apr 18. PMID: 37111366

Article Published Date : Apr 17, 2023

Authors : Siti Nur Hidayah Jamil, Amatul Hamizah Ali, Shevin Rizal Feroz, Su Datt Lam, Hani Kartini Agustar, Mohd Ridzuan Mohd Abd Razak, Jalifah Latip

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Malaria : CK(303) : AC(135)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antimalarials : CK(125) : AC(78)

curcumin and its major metabolites inhibited the LPS‑induced inflammatory response via the mechanism of inhibiting NF‑κB translocation to the nucleus.

Pubmed Data : Mol Med Rep. 2015 Apr ;11(4):3087-93. Epub 2014 Dec 11. PMID: 25502175

Article Published Date : Mar 31, 2015

Authors : Feng Zhao, Yudian Gong, Yuan Hu, Minghui Lu, Jing Wang, Jianxin Dong, Daquan Chen, Lei Chen, Fenghua Fu, Feng Qiu

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Curcumin: Degradiation byproducts : CK(13) : AC(8)

Diseases : Inflammation : CK(16108) : AC(5498), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin and piperine afforded a better neuroprotective effect compared to each of them alone.

Pubmed Data : Inflammopharmacology. 2016 Nov 16. Epub 2016 Nov 16. PMID: 27853890

Article Published Date : Nov 15, 2016

Authors : Shamsher Singh, Puneet Kumar

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Piperine : CK(600) : AC(258)

Diseases : Brain Inflammation : CK(1784) : AC(928), Parkinson's Disease : CK(3012) : AC(1116)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Neuroprotective Agents : CK(20061) : AC(7949), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Additional Keywords : Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806), CURCUMIN : CK(25) : AC(18), CURCUMIN : CK(25) : AC(18), Natural Substance Synergy : CK(1400) : AC(669), Natural Substance Synergy : CK(1400) : AC(669), Natural Substance Synergy : CK(1400) : AC(669)

Curcumin and piperine in COVID-19: a promising duo to the rescue?

Pubmed Data : Adv Exp Med Biol. 2021 ;1327:197-204. PMID: 34279840

Article Published Date : Dec 31, 2020

Authors : Mahsa Miryan, Davood Soleimani, Gholamreza Askari, Tannaz Jamialahmadi, Paul C Guest, Mohammad Bagherniya, Amirhossein Sahebkar

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Piperine : CK(600) : AC(258)

Diseases : Coronavirus Infection : CK(3250) : AC(986)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Antiviral Agents : CK(3095) : AC(1702), Immunomodulatory : CK(6531) : AC(2360)

Curcumin and piperine showed strong antioxidant and protective effect against QA-induced behavioural and neurological alteration.

Pubmed Data : Pharmacology. 2016 Jan 30 ;97(3-4):151-160. Epub 2016 Jan 30. PMID: 26828892

Article Published Date : Jan 29, 2016

Authors : Shamsher Singh, Puneet Kumar

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Piperine : CK(600) : AC(258)

Diseases : Brain Inflammation : CK(1784) : AC(928)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

Curcumin and quercetin inhibit inflammatory processes associated with arthritis.

Pubmed Data : Inflamm Res. 2006 Apr;55(4):168-75. PMID: 16807698

Article Published Date : Apr 01, 2006

Authors : J K Jackson, T Higo, W L Hunter, H M Burt

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Quercetin : CK(1876) : AC(855)

Diseases : Arthritis : CK(5826) : AC(1505), Arthritis: Rheumatoid : CK(338) : AC(65), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379)

Curcumin and resveratrol regulate intestinal bacteria and alleviate intestinal inflammation.

Pubmed Data : Molecules. 2019 Mar 28 ;24(7). Epub 2019 Mar 28. PMID: 30925757

Article Published Date : Mar 27, 2019

Authors : Zhending Gan, Wenyao Wei, Yi Li, Jiamin Wu, Yongwei Zhao, Lili Zhang, Tian Wang, Xiang Zhong

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Resveratrol : CK(3228) : AC(1513)

Diseases : Gastrointestinal Inflammation : CK(330) : AC(157)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin and saikosaponin A inhibit chemical-induced liver inflammation and fibrosis in rats.

Pubmed Data : Mol Vis. 2007 Jul 24;13:1291-7. PMID: 20128048

Article Published Date : Jul 24, 2007

Authors : Shu-Ju Wu, Ka-Wai Tam, Ya-Hui Tsai, Chun-Chao Chang, Jane C-J Chao

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Saikosaponin : CK(69) : AC(52)

Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Hepatitis : CK(151) : AC(60), Inflammation : CK(16108) : AC(5498), Liver Fibrosis : CK(882) : AC(399)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Curcumin and selenium can hinder the progression and severity of liver injury during acute inflammatory episodes.

Pubmed Data : Biol Trace Elem Res. 2019 Oct 25. Epub 2019 Oct 25. PMID: 31654258

Article Published Date : Oct 24, 2019

Authors : Manal H Al-Dossari, Laila M Fadda, Hala A Attia, Iman H Hasan, Ayman M Mahmoud

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Selenium : CK(1753) : AC(393)

Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875), Liver Damage: Drug-Induced : CK(651) : AC(285)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Problem Substances : Diclofenac : CK(231) : AC(52)

Curcumin and vitamin C attenuate gentamicin-induced nephrotoxicity.

Pubmed Data : Metabolites. 2022 Dec 28 ;13(1). Epub 2022 Dec 28. PMID: 36676974

Article Published Date : Dec 27, 2022

Authors : Anamaria Magdalena Tomşa, Andreea Liana Răchişan, Stanca Lucia Pandrea, Andreea Benea, Ana Uifălean, Corina Toma, Roxana Popa, Alina Elena Pârvu, Lia Monica Junie

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Vitamin C : CK(6066) : AC(1408)

Diseases : Chemotherapy-Induced Kidney Damage : CK(289) : AC(145), Chemotherapy-Induced Toxicity: Gentamicin : CK(194) : AC(102)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Chemoprotective Agents : CK(4278) : AC(1621), Interleukin-10 upregulation : CK(1296) : AC(436), Renoprotective : CK(4544) : AC(1971)

Curcumin and vitamin D supplement attenuates knee osteoarthritis progression.

Pubmed Data : Nutrients. 2025 Jan 19 ;17(2). Epub 2025 Jan 19. PMID: 39861479

Article Published Date : Jan 18, 2025

Authors : Lokesh Kumar Mende, Yaswanth Kuthati, Chih-Shung Wong

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Vitamin D : CK(11762) : AC(1712)

Diseases : Osteoarthritis: Knee : CK(2345) : AC(276), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Analgesics : CK(9680) : AC(1472), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Interleukin-10 upregulation : CK(1296) : AC(436)

Curcumin and Wnt/β‑catenin signaling in exudative age‑related macular degeneration.

Pubmed Data : Int J Mol Med. 2022 Jun ;49(6). Epub 2022 Apr 21. PMID: 35445729

Article Published Date : May 31, 2022

Authors : Alexandre Vallée

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Inflammation : CK(16108) : AC(5498), Macular Degeneration : CK(604) : AC(173)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Wnt/β-catenin signaling pathway modulation : CK(330) : AC(224)

Curcumin appears to be a complementary treatment option for COVID-19 patients.

Pubmed Data : Adv Exp Med Biol. 2023 ;1412:413-426. PMID: 37378780

Article Published Date : Dec 31, 2022

Authors : Gholamreza Askari, Mohammad Bagherniya, Zahra Kiani, Babak Alikiaii, Mahdiye Mirjalili, Mehrnaz Shojaei, Shirin Hassanizadeh, Mahdi Vajdi, Awat Feizi, Muhammed Majeed, Amirhossein Sahebkar

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Piperine : CK(600) : AC(258)

Diseases : Coronavirus Infection : CK(3250) : AC(986)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin as a potential protective compound against cardiac diseases.

Pubmed Data : Pharmacol Res. 2017 Mar 6 ;119:373-383. Epub 2017 Mar 6. PMID: 28274852

Article Published Date : Mar 05, 2017

Authors : Shuai Jiang, Jing Han, Tian Li, Zhenlong Xin, Zhiqiang Ma, Wencheng Di, Wei Hu, Bing Gong, Shouyin Di, Dongjin Wang, Yang Yang

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cardiovascular Diseases : CK(17333) : AC(2878)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin as a therapeutic agent in leukemia.

Pubmed Data : J Cell Physiol. 2019 Aug ;234(8):12404-12414. Epub 2019 Jan 4. PMID: 30609023

Article Published Date : Jul 31, 2019

Authors : Hamideh Kouhpeikar, Alexandra E Butler, Faeze Bamian, George E Barreto, Muhammed Majeed, Amirhossein Sahebkar

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Leukemia : CK(2094) : AC(910)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Chemotherapeutic : CK(4390) : AC(1635), Immunomodulatory : CK(6531) : AC(2360)

Curcumin as a therapeutic candidate for multiple sclerosis: Molecular mechanisms and targets.

Pubmed Data : J Cell Physiol. 2019 08 ;234(8):12237-12248. Epub 2018 Dec 10. PMID: 30536381

Article Published Date : Dec 31, 2018

Authors : Negar Ghanaatian, Naser-Aldin Lashgari, Amir Hossein Abdolghaffari, Seyed M Rajaee, Yunes Panahi, George E Barreto, Alexandra E Butler, Amirhossein Sahebkar

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Multiple Sclerosis : CK(2432) : AC(557)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin as prospective anti-aging natural compound: focus on brain.

Pubmed Data : Molecules. 2021 Aug 7 ;26(16). Epub 2021 Aug 7. PMID: 34443381

Article Published Date : Aug 06, 2021

Authors : Tarek Benameur, Raffaella Soleti, Maria Antonietta Panaro, Maria Ester La Torre, Vincenzo Monda, Giovanni Messina, Chiara Porro

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Aging: Brain : CK(1118) : AC(268)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin attenuated glucose intolerance and insulin resistance through its antioxidant and anti-inflammatory effects.

Pubmed Data : Chem Biol Interact. 2015 Dec 20. Epub 2015 Dec 20. PMID: 26713546

Article Published Date : Dec 19, 2015

Authors : Nachimuthu Maithilikarpagaselvi, Magadi Gopalakrishna Sridhar, Rathinam Palamalai Swaminathan, Bobby Zachariah

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : C-Reactive Protein : CK(3950) : AC(392), Diabetes Mellitus: Type 2 : CK(12953) : AC(2579), Inflammation : CK(16108) : AC(5498), Insulin Resistance : CK(4864) : AC(1098), Obesity : CK(11004) : AC(2672)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Malondialdehyde Down-regulation : CK(3028) : AC(992), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin attenuated neuropathic pain and down-regulated the production of spinal mature IL-1β.

Pubmed Data : Sci Rep. 2016;6:28956. Epub 2016 Jul 6. PMID: 27381056

Article Published Date : Dec 31, 2015

Authors : Shenbin Liu, Qian Li, Meng-Ting Zhang, Qi-Liang Mao-Ying, Lang-Yue Hu, Gen-Cheng Wu, Wen-Li Mi, Yan-Qing Wang

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Neuropathic Pain : CK(922) : AC(324)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940)

Curcumin attenuated neurotoxicity in sporadic animal model of Alzheimer's disease.

Pubmed Data : Molecules. 2021 May 18 ;26(10). Epub 2021 May 18. PMID: 34070220

Article Published Date : May 17, 2021

Authors : Ines ELBini-Dhouib, Raoudha Doghri, Amenallah Ellefi, Imen Degrach, Najet Srairi-Abid, Asma Gati

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin attenuates airway hyperreactivity induced by ischemia-reperfusion of the pancreas in rats.

Pubmed Data : Transplant Proc. 2010 Apr;42(3):744-7. PMID: 20430162

Article Published Date : Apr 01, 2010

Authors : K H Chen, D Chao, C F Liu, C F Chen, D Wang

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Allergic Airway Diseases : CK(80) : AC(32), Hypersensitivity : CK(144) : AC(39), Pancreatitis : CK(500) : AC(186)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin attenuates angiotensin II-induced abdominal aortic aneurysm.

Pubmed Data : Evid Based Complement Alternat Med. 2014 ;2014:270930. Epub 2014 Nov 6. PMID: 25431606

Article Published Date : Dec 31, 2013

Authors : QingQing Hao, Xu Chen, XiaoYu Wang, Bo Dong, ChuanHua Yang

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Aneurysm: Aortic : CK(125) : AC(40)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin attenuates both acute and chronic immune nephritis.

Pubmed Data : Int J Mol Sci. 2020 Mar 4 ;21(5). Epub 2020 Mar 4. PMID: 32143311

Article Published Date : Mar 03, 2020

Authors : Tianfu Wu, Bindiya Marakkath, Yujin Ye, Elhaum Khobahy, Mei Yan, Jack Hutcheson, Jiankun Zhu, Xinjin Zhou, Chandra Mohan

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Nephritis : CK(47) : AC(12)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Immunomodulatory : CK(6531) : AC(2360)

Curcumin attenuates Concanavalin A-induced liver injury in mice.

Pubmed Data : Int Immunopharmacol. 2012 Jan ;12(1):151-7. Epub 2011 Dec 2. PMID: 22138522

Article Published Date : Dec 31, 2011

Authors : Chuan-tao Tu, Bing Han, Qun-yan Yao, Yi-an Zhang, Hong-chun Liu, Shun-cai Zhang

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Hepatitis: Lectin-Induced (concanavalin) : CK(58) : AC(31)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831)

Curcumin attenuates inflammation in experimental colitis.

Pubmed Data : Mol Cell Biochem. 2009 Feb;322(1-2):127-35. Epub 2008 Nov 11. PMID: 19002562

Article Published Date : Feb 01, 2009

Authors : A Lubbad, M A Oriowo, I Khan

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Colitis : CK(1542) : AC(735)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin attenuates intracerebral hemorrhage-induced neuronal apoptosis and neuroinflammation.

Pubmed Data : Biochem Cell Biol. 2022 Apr 5. Epub 2022 Apr 5. PMID: 35381181

Article Published Date : Apr 04, 2022

Authors : Fei Wang, Jian-Jun Xia, Li-Juan Shen, Ting-Ting Jiang, Wu-Lin Li, Da-Li You, Qing Chang, Shan-You Hu, Li Wang, Xiao Wu

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Intracerebral Hemorrhage : CK(292) : AC(54)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin attenuates retinal oxidative stress and inflammation in diabetes.

Pubmed Data : Nutr Metab (Lond). 2007;4:8. Epub 2007 Apr 16. PMID: 17437639

Article Published Date : Jan 01, 2007

Authors : Renu A Kowluru, Mamta Kanwar

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Diabetic Retinopathy : CK(483) : AC(211)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin attenuates sarcopenia in chronic forced exercise executed aged mice.

Pubmed Data : J Agric Food Chem. 2021 May 5. Epub 2021 May 5. PMID: 33950680

Article Published Date : May 04, 2021

Authors : Da-Yeon Lee, Yoon-Seok Chun, Jong-Kyu Kim, Jeong-Ok Lee, Sae-Kwang Ku, Soon-Mi Shim

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Sarcopenia : CK(368) : AC(79)

Therapeutic Actions : Exercise : CK(6919) : AC(1026)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin attenuates the development of allergic airway inflammation and hyper-responsiveness.

Pubmed Data : J Ethnopharmacol. 2010 Jul 17. Epub 2010 Jul 17. PMID: 20643202

Article Published Date : Jul 17, 2010

Authors : Se-Woong Oh, Joo-Young Cha, Ji-Eun Jung, Beom-Chol Chang, Hyo-Jung Kwon, Bo-Ram Lee, Dae-Yong Kim

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Allergic Airway Diseases : CK(80) : AC(32), Asthma : CK(3242) : AC(707), Hypersensitivity : CK(144) : AC(39)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin attenuates the inflammatory response in collagen-induced arthritis.

Pubmed Data : Int Immunopharmacol. 2010 May;10(5):605-10. Epub 2010 Feb 23. PMID: 20188213

Article Published Date : May 01, 2010

Authors : Dong-Oh Moon, Mun-Ok Kim, Yung Hyun Choi, Yung-Min Park, Gi-Young Kim

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Arthritis : CK(5826) : AC(1505)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antiproliferative : CK(10001) : AC(7491), Interleukin-1 beta downregulation : CK(6063) : AC(2940)

Curcumin attenuates the organ dysfunction caused by endotoxemia in the rat.

Pubmed Data : Nutrition. 2008 Nov-Dec;24(11-12):1133-8. Epub 2008 Aug 26. PMID: 18752929

Article Published Date : Nov 01, 2008

Authors : Dilek Memis, Sevtap Hekimoglu, Atakan Sezer, Semsi Altaner, Necdet Sut, Ufuk Usta

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Endotoxemia : CK(359) : AC(127)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin attenuates the severity of premenstrual syndrome symptoms.

Pubmed Data : Complement Ther Med. 2015 Jun ;23(3):318-24. Epub 2015 Apr 9. PMID: 26051565

Article Published Date : May 31, 2015

Authors : Samira Khayat, Hamed Fanaei, Masoomeh Kheirkhah, Zahra Behboodi Moghadam, Amir Kasaeian, Mani Javadimehr

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Premenstrual syndrome : CK(507) : AC(55)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin attenuates ulcerative colitis.

Pubmed Data : Biofactors. 2025 ;51(1):e70001. PMID: 39832759

Article Published Date : Dec 31, 2024

Authors : Xiuli Zhang, Hao Zhang, Jingting Wang, Yangyi Chen, Jiumao Lin, Qingshui Wang, Cheng Wu, Hui Chen, Yao Lin

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Ulcerative Colitis : CK(1411) : AC(447)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), NF-kappaB Inhibitor : CK(5952) : AC(3464), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin blocks the activation of pancreatic stellate cells associated with inflammation and fibrosis.

Pubmed Data : J Cell Biochem. 2006 Apr 1;97(5):1080-93. PMID: 16294327

Article Published Date : Apr 01, 2006

Authors : Atsushi Masamune, Noriaki Suzuki, Kazuhiro Kikuta, Masahiro Satoh, Kennichi Satoh, Tooru Shimosegawa

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Pancreatic Diseases : CK(52) : AC(11), Pancreatic Fibrosis : CK(4) : AC(4), Pancreatitis : CK(500) : AC(186)

Pharmacological Actions : Anti-Fibrotic : CK(2209) : AC(1052), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antiproliferative : CK(10001) : AC(7491), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin can act as a suitable therapeutic agent against sepsis-induced chronic lung injury.

Pubmed Data : J Nutr Health Aging. 2017 ;21(3):307-313. PMID: 28244571

Article Published Date : Dec 31, 2016

Authors : Y-F Liu, C-W Yang, H Liu, S-G Sui, X-D Li

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Lipid Peroxidation : CK(2057) : AC(806), Lung Injury: Acute : CK(533) : AC(253), Sepsis : CK(1436) : AC(491)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Interleukin-1 alpha downregulation : CK(162) : AC(67), Malondialdehyde Down-regulation : CK(3028) : AC(992), Superoxide Dismutase Up-regulation : CK(2383) : AC(928), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin can alleviate S. aureus-induced acute lung injury through multiple pathways.

Pubmed Data : Clin Respir J. 2015 Jan ;9(1):87-97. Epub 2014 Mar 20. PMID: 24460792

Article Published Date : Dec 31, 2014

Authors : Feng Xu, Ran Diao, Jin Liu, Yanhua Kang, Xuanding Wang, Liyun Shi

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Staphylococcus aureus infection : CK(776) : AC(576)

Pharmacological Actions : Anti-Bacterial Agents : CK(4228) : AC(1989), Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin can ameliorate hyperglycemia and inflammation in T2D compared to a placebo.

Pubmed Data : Nutrients. 2024 Nov 30 ;16(23). Epub 2024 Nov 30. PMID: 39683570

Article Published Date : Nov 29, 2024

Authors : Kabelo Mokgalaboni, Reneilwe G Mashaba, Wendy N Phoswa, Sogolo L Lebelo

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Diabetes Mellitus: Type 2 : CK(12953) : AC(2579), Hyperglycemia : CK(2240) : AC(709), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hypoglycemic Agents : CK(9221) : AC(2076)

Curcumin can attenuate the downregulation of CISD2 in spinal cord injuries and LPS-treated astrocytes.

Pubmed Data : Injury. 2015 Aug 8. Epub 2015 Aug 8. PMID: 26387034

Article Published Date : Aug 07, 2015

Authors : Chai-Ching Lin, Tien-Huang Chiang, Wei-Jung Chen, Yu-Yo Sun, Yi-Hsuan Lee, Muh-Shi Lin

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain Inflammation : CK(1784) : AC(928), Spinal Cord Injuries : CK(890) : AC(347)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), MicroRNA modulator : CK(1560) : AC(897), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin can effectively decrease the pathological results of osteoarthritis.

Pubmed Data : Altern Ther Health Med. 2022 Apr 22. Epub 2022 Apr 22. PMID: 35452417

Article Published Date : Apr 21, 2022

Authors : Tangbo Yuan, Dawei Cai, Bo Hu, Yiran Zhu, Jian Qin

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Chondroprotective : CK(226) : AC(116)

Curcumin can reduce blood glucose and HbA1c level by reduction in hepatic glucose production and glycogen synthesis and stimulation of glucose uptake

Pubmed Data : Int J Endocrinol Metab. 2014 Oct ;12(4):e18081. Epub 2014 Oct 1. PMID: 25745485

Article Published Date : Sep 30, 2014

Authors : Zeinab Ghorbani, Azita Hekmatdoost, Parvin Mirmiran

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)

Diseases : Hyperglycemia : CK(2240) : AC(709), Insulin Resistance : CK(4864) : AC(1098)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidant Effects : CK(159) : AC(45), Hypoglycemic Agents : CK(9221) : AC(2076), Insulin Sensitizers : CK(1957) : AC(422)

Additional Keywords : Gene Expression Regulation : CK(1401) : AC(623)

Curcumin can reduce inflammation and offset some of the performance deficits associated with eccentric exercise-induced muscle damage.

Pubmed Data : Am J Physiol Regul Integr Comp Physiol. 2007 Jun;292(6):R2168-73. Epub 2007 Mar 1. PMID: 17332159

Article Published Date : Jun 01, 2007

Authors : J Mark Davis, E Angela Murphy, Martin D Carmichael, Mark R Zielinski, Claire M Groschwitz, Adrienne S Brown, J David Gangemi, Abdul Ghaffar, Eugene P Mayer

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Exercise-Induced Tissue Damage : CK(98) : AC(17), Inflammation : CK(16108) : AC(5498), Muscle Soreness: Exercise-Induced : CK(360) : AC(39)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin can reduce the degree of severity of acute lung injury and uncontrolled inflammation.

Pubmed Data : Biomed Pharmacother. 2020 May ;125:109946. Epub 2020 Jan 28. PMID: 32004976

Article Published Date : Apr 30, 2020

Authors : Yu-Sen Chai, Yan-Qing Chen, Shi-Hui Lin, Ke Xie, Chuan-Jiang Wang, Yuan-Zheng Yang, Fang Xu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Lung Injury: Acute : CK(533) : AC(253), Respiratory Distress Syndrome : CK(65) : AC(18)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360), Interleukin-10 upregulation : CK(1296) : AC(436)

Curcumin could be a novel treatment for skin-related disorders.

Pubmed Data : J Drugs Dermatol. 2013 Oct ;12(10):1131-7. PMID: 24085048

Article Published Date : Sep 30, 2013

Authors : Tuyet A Nguyen, Adam J Friedman

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Melanoma : CK(924) : AC(552), Psoriasis : CK(922) : AC(255), Skin Cancer : CK(1759) : AC(833), Squamous cell carcinoma : CK(676) : AC(348)

Pharmacological Actions : Anti-Bacterial Agents : CK(4228) : AC(1989), Anti-Inflammatory Agents : CK(39737) : AC(15858)

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(3243) : AC(656)

Curcumin could be of therapeutic use in the treatment of spinal cord injury.

Pubmed Data : Neurol Res Int. 2016 ;2016:9468193. Epub 2016 May 19. PMID: 27298735

Article Published Date : Dec 31, 2015

Authors : Raghavendra Sanivarapu, Vijayalakshmi Vallabhaneni, Vivek Verma

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Spinal Cord Injuries : CK(890) : AC(347)

Pharmacological Actions : Anti-Fibrotic : CK(2209) : AC(1052), Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin could be used as an adjuvant agent to chemotherapy in treatment of triple negative breast cancer.

Pubmed Data : Biomed Res Int. 2015 ;2015:878134. Epub 2015 Mar 23. PMID: 25879038

Article Published Date : Dec 31, 2014

Authors : Sabrina Bimonte, Antonio Barbieri, Giuseppe Palma, Domenica Rea, Antonio Luciano, Massimiliano D'Aiuto, Claudio Arra, Francesco Izzo

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Breast Cancer : CK(8297) : AC(3043), Breast Cancer: Triple Negative : CK(970) : AC(659)

Pharmacological Actions : Angiogenesis Inhibitors : CK(724) : AC(481), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin could be used for peripheral arterial disease treatment.

Pubmed Data : Med Sci Monit. 2016 ;22:2035-42. Epub 2016 Jun 15. PMID: 27302110

Article Published Date : Dec 31, 2015

Authors : Yang Liu, Lianyu Chen, Yi Shen, Tao Tan, Nanzi Xie, Ming Luo, Zhihong Li, Xiaoyun Xie

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Ischemia : CK(626) : AC(325), Peripheral Arterial Disease : CK(420) : AC(45)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360), Interleukin-6 Downregulation : CK(9337) : AC(3613), NF-kappaB Inhibitor : CK(5952) : AC(3464), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin could have a role in promoting neural function recovery after SCI by the joint inhibition of the intracellular and extracellular components of glial scar.

Pubmed Data : J Surg Res. 2015 May 1 ;195(1):235-45. Epub 2015 Jan 7. PMID: 25661742

Article Published Date : Apr 30, 2015

Authors : Jichao Yuan, Mingming Zou, Xin Xiang, Haitao Zhu, Weihua Chu, Wei Liu, Fei Chen, Jiangkai Lin

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Spinal Cord Injuries : CK(890) : AC(347)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613), NF-kappaB Inhibitor : CK(5952) : AC(3464), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Curcumin could protect against the vascular side effects of methotrexate by preventing an increase in oxidative stress.

Pubmed Data : Can J Physiol Pharmacol. 2015 Nov 16:1-8. Epub 2015 Nov 16. PMID: 26571019

Article Published Date : Nov 15, 2015

Authors : Himanshu Sankrityayan, Anuradha S Majumdar

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Folic Acid : CK(1317) : AC(206)

Diseases : Drug Toxicity: Methotrexate : CK(194) : AC(100), Endothelial Dysfunction : CK(2733) : AC(581), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin could reverse the development of depression and enhance the outcome of antidepressants treatment in major depressive disorder.

Pubmed Data : J Clin Psychopharmacol. 2015 Aug ;35(4):406-10. PMID: 26066335

Article Published Date : Jul 31, 2015

Authors : Jing-Jie Yu, Liu-Bao Pei, Yong Zhang, Zi-Yu Wen, Jian-Li Yang

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Depression : CK(9574) : AC(1756)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antidepressive Agents : CK(7908) : AC(1466), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Additional Keywords : Natural Substance/Drug Synergy : CK(1526) : AC(720), Significant Treatment Outcome : CK(4297) : AC(505)

Problem Substances : Antidepressants : CK(1033) : AC(153)

Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis.

Pubmed Data : Int J Cancer. 2010 Sep 7. Epub 2010 Sep 7. PMID: 20824699

Article Published Date : Sep 07, 2010

Authors : Suksanti Prakobwong, Jarinya Khoontawad, Puangrat Yongvanit, Chawalit Pairojkul, Yusuke Hiraku, Paiboon Sithithaworn, Porntip Pinlaor, Bharat B Aggarwal, Somchai Pinlaor

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cholangiocarcinoma : CK(213) : AC(91)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anti-Proliferative : CK(68) : AC(56), Chemopreventive : CK(6580) : AC(2166), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(1141) : AC(720), Vascular Endothelial Growth Factor Inhibitors : CK(611) : AC(335)

Curcumin displays therapeutic value in an animal model of irritable bowel syndrome.

Pubmed Data : AAPS PharmSciTech. 2009;10(3):752-62. Epub 2009 Jun 3. PMID: 19495987

Article Published Date : Jan 01, 2009

Authors : Vivek R Yadav, Sarasija Suresh, Kshama Devi, Seema Yadav

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Colitis : CK(1542) : AC(735), Irritable Bowel Syndrome : CK(1492) : AC(230)

Pharmacological Actions : Anti-Angiogenic : CK(421) : AC(284), Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin effectively attenuates brain edema in mice with ICH through inhibition of the NF-κB pathway and subsequently the expression of AQP4 and AQP9.

Pubmed Data : Acta Pharmacol Sin. 2015 Jun 29. Epub 2015 Jun 29. PMID: 26119880

Article Published Date : Jun 28, 2015

Authors : Bao-Feng Wang, Zhen-Wen Cui, Zhi-Hong Zhong, Yu-Hao Sun, Qing-Fang Sun, Guo-Yuan Yang, Liu-Guan Bian

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain Edema : CK(51) : AC(14), Intracerebral Hemorrhage : CK(292) : AC(54), Stroke: Attenuation/Recovery : CK(998) : AC(156)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Additional Keywords : Dose Response : CK(1770) : AC(700), Gene Expression Regulation : CK(1401) : AC(623)

Curcumin elevates TFH cells and germinal center B cell response for antibody production in mice.

Pubmed Data : Immune Netw. 2019 Oct ;19(5):e35. Epub 2019 Oct 17. PMID: 31720046

Article Published Date : Sep 30, 2019

Authors : Do-Hyun Kim, Hong-Gyun Lee, Je-Min Choi

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cancers: All : CK(36404) : AC(14363), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin encapsulation in geranium oil microemulsion elevates its antibacterial, antioxidant, anti-inflammatory, and anticancer activities.

Pubmed Data : ACS Omega. 2024 Feb 6 ;9(5):5624-5636. Epub 2024 Jan 23. PMID: 38343911

Article Published Date : Feb 05, 2024

Authors : Shahzadi Filza Hassan, Sajid Asghar, Ikram Ullah Khan, Rabia Munir, Syed Haroon Khalid

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Geranium : CK(88) : AC(36)

Diseases : Escherichia coli Infections : CK(603) : AC(450), Inflammation : CK(16108) : AC(5498), Liver Cancer : CK(3119) : AC(1641), Staphylococcus aureus infection : CK(776) : AC(576)

Pharmacological Actions : Anti-Bacterial Agents : CK(4228) : AC(1989), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin exerts anti-inflammatory and vasoprotective effects in mice with acute Chagas cardiomyopathy.

Pubmed Data : Mem Inst Oswaldo Cruz. 2018 Jul 16 ;113(9):e180171. Epub 2018 Jul 16. PMID: 30020318

Article Published Date : Jul 15, 2018

Authors : Matías Hernández, Susana Wicz, Miguel H Santamaría, Ricardo S Corral

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cardiomyopathy : CK(390) : AC(171), Chagas Disease : CK(25) : AC(14)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Vasoprotective : CK(451) : AC(108)

Curcumin exerts protective effects against valproic acid-induced testicular damage.

Pubmed Data : Iran J Basic Med Sci. 2025 ;28(2):230-236. PMID: 39850114

Article Published Date : Dec 31, 2024

Authors : Eda Dokumacioglu, Hatice Iskender, Kubra Asena Terim Kapakin, İSmail Bolat, Behzat Mokhtare, Ali Dogan Omur, Armagan Hayirli

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Testicular Injury: Chemical/Metal Induced : CK(774) : AC(385)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin exerts protective metabolic effects in dietary obesity.

Pubmed Data : Mol Nutr Food Res. 2021 Nov ;65(22):e2100274. Epub 2021 Oct 7. PMID: 34510720

Article Published Date : Oct 31, 2021

Authors : Tariful Islam, Iurii Koboziev, Kembra Albracht-Schulte, Brandon Mistretta, Shane Scoggin, Mohammad Yosofvand, Hanna Moussa, Masoud Zabet-Moghaddam, Latha Ramalingam, Preethi H Gunaratne, Naima Moustaid-Moussa

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Inflammation : CK(16108) : AC(5498), Obesity : CK(11004) : AC(2672)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Gastrointestinal Agents : CK(7657) : AC(2274)

Curcumin exhibits anti-inflammatory and anti-atherosclerotic properties.

Pubmed Data : Eur J Pharmacol. 1992 Oct 20;221(2-3):381-4. PMID: 1426014

Article Published Date : Oct 20, 1992

Authors : H C Huang, T R Jan, S F Yeh

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Atherosclerosis : CK(2063) : AC(778), Inflammation : CK(16108) : AC(5498), Restenosis : CK(152) : AC(36)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antiproliferative : CK(10001) : AC(7491)

Curcumin exhibits anti-inflammatory properties in leukemia cells.

Pubmed Data : Ann N Y Acad Sci. 2009 Aug;1171:391-8. PMID: 19723081

Article Published Date : Aug 01, 2009

Authors : Marie-Helene Teiten, Serge Eifes, Simone Reuter, Annelyse Duvoix, Mario Dicato, Marc Diederich

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Leukemia : CK(2094) : AC(910)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Heat Shock Protein Inducer : CK(156) : AC(57), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Additional Keywords : Heat Shock Protein Inducer : CK(7) : AC(5)

Curcumin exhibits anti-inflammatory properties in rat brain homegenates.

Pubmed Data : Mol Cell Biochem. 1994 Nov 9;140(1):73-9. PMID: 7877600

Article Published Date : Nov 09, 1994

Authors : D V Rajakumar, M N Rao

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain Inflammation : CK(1784) : AC(928), Lipid Peroxidation : CK(2057) : AC(806)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin exhibits anti-rheumatoid activity.

Pubmed Data : Eur J Pharmacol. 2009 Jun 10;612(1-3):161-6. Epub 2009 Apr 14. PMID: 19371737

Article Published Date : Jun 10, 2009

Authors : Viera Jancinová, Tomás Perecko, Radomír Nosál, Daniela Kostálová, Katarína Bauerová, Katarína Drábiková

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Arthritis: Rheumatoid : CK(338) : AC(65)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin exhibits gut-mediated anti-inflammatory/anti-arthritic activity.

Pubmed Data : Pharmacol Res. 2015 Mar 30. Epub 2015 Mar 30. PMID: 25836921

Article Published Date : Mar 29, 2015

Authors : Yan Yang, Xin Wu, Zhifeng Wei, Yannong Dou, Di Zhao, Ting Wang, Difei Bian, Bei Tong, Ying Xia, Yufeng Xia, Yue Dai

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Arthritis : CK(5826) : AC(1505)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin exhibits salutary effects against adenine-induced chronic kidney disease in rats by reducing inflammation and oxidative stress.

Pubmed Data : Basic Clin Pharmacol Toxicol. 2017 May 31. Epub 2017 May 31. PMID: 28561324

Article Published Date : May 30, 2017

Authors : Badreldin H Ali, Suhail Al-Salam, Yousuf Al Suleimani, Jamila Al Kalbani, Shadia Al Bahlani, Mohammed Ashique, Priyadarsini Manoj, Buthaina Al Zhili, Nadia Al Abri, Heba T Naser, Javed Yasin, Abderrahim Nemmar, Mohamed Al Za'abi, Christina Hartmann, Nicole Schupp

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Chronic Kidney Disease (CKD) : CK(1186) : AC(211)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Nrf2 activation : CK(3156) : AC(1794)

Curcumin functions as an anti-inflammatory and antioxidant agent on arsenic-induced hepatic and kidney injury.

Pubmed Data : Environ Toxicol. 2021 Jul 17. Epub 2021 Jul 17. PMID: 34272803

Article Published Date : Jul 16, 2021

Authors : Guowei Xu, Yuqin Gu, Nan Yan, Yongfang Li, Lin Sun, Bing Li

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Kidney Damage: Chemically-Induced : CK(561) : AC(281)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Nrf2 activation : CK(3156) : AC(1794), Renoprotective : CK(4544) : AC(1971)

Problem Substances : Arsenic : CK(608) : AC(184)

Curcumin had protective effects against cerebral ischemia/reperfusion injury in animals.

Pubmed Data : Microvasc Res. 2015 Dec 11. Epub 2015 Dec 11. PMID: 26686249

Article Published Date : Dec 10, 2015

Authors : Wei Li, Nijasri C Suwanwela, Suthiluk Patumraj

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain Edema : CK(51) : AC(14), Cerebral Ischemia : CK(1183) : AC(566)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949), NF-kappaB Inhibitor : CK(5952) : AC(3464), Nrf2 activation : CK(3156) : AC(1794)

Curcumin has a great potential to treat psoriasis from these results.

Pubmed Data : Biochimie. 2016 Jan 27. Epub 2016 Jan 27. PMID: 26826458

Article Published Date : Jan 26, 2016

Authors : Di Kang, Bowen Li, Lei Luo, Wenbing Jiang, Qiumin Lu, Mingqing Rong, Ren Lai

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Psoriasis : CK(922) : AC(255)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin has a potent anti-inflammatory and anti- oxidant effects against atherosclerosis.

Pubmed Data : Indian J Clin Biochem. 2021 Jan ;36(1):74-80. Epub 2019 Nov 19. PMID: 33505130

Article Published Date : Dec 31, 2020

Authors : Murooj L Majeed, Fadhaa A Ghafil, Ghizal Fatima, Najah R Hadi, Hind F Mahdi

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Atherosclerosis : CK(2063) : AC(778), Hypercholesterolemia : CK(2706) : AC(482)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin has a potential anti-inflammatory action against aluminum exposure.

Pubmed Data : Neurochem Res. 2012 Mar ;37(3):639-46. Epub 2011 Dec 1. PMID: 22130689

Article Published Date : Feb 29, 2012

Authors : Pooja Khanna Sood, Uma Nahar, Bimla Nehru

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Aluminum Toxicity : CK(735) : AC(318), Brain Inflammation : CK(1784) : AC(928)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949), NF-kappaB Inhibitor : CK(5952) : AC(3464), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Problem Substances : Aluminum : CK(1075) : AC(356)

Curcumin has a preventive effect on experimental acute pancreatitis in mouse.

Pubmed Data : Indian J Med Res. 2011 Nov ;134(5):717-24. PMID: 22199113

Article Published Date : Nov 01, 2011

Authors : Wen-Guang Yu, Gang Xu, Gui-Jie Ren, Xia Xu, Hui-Qing Yuan, Xiao-Li Qi, Ke-Li Tian

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Pancreatitis : CK(500) : AC(186)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin has a profound anti-inflammatory therapeutic potential in the treatment of spinal cord injury.

Pubmed Data : Int J Mol Sci. 2016 ;17(1). Epub 2015 Dec 31. PMID: 26729105

Article Published Date : Dec 31, 2015

Authors : Lucia Machova Urdzikova, Kristyna Karova, Jiri Ruzicka, Anna Kloudova, Craig Shannon, Jana Dubisova, Raj Murali, Sarka Kubinova, Eva Sykova, Meena Jhanwar-Uniyal, Pavla Jendelova

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Spinal Cord Injuries : CK(890) : AC(347)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-2 Downregulation : CK(177) : AC(73), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin has a promising role as a cardioprotective agent against palmitate and high fat diet mediated cardiac dysfunction.

Pubmed Data : J Mol Cell Cardiol. 2015 Feb ;79:1-12. Epub 2014 Oct 16. PMID: 25444713

Article Published Date : Jan 31, 2015

Authors : Chunlai Zeng, Peng Zhong, Yunjie Zhao, Karvannan Kanchana, Yali Zhang, Zia A Khan, Subrata Chakrabarti, Lianpin Wu, Jingying Wang, Guang Liang

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Circulating Free Fatty Acids: Elevated : CK(3) : AC(2), High Fat Diet : CK(2040) : AC(984), Obesity : CK(11004) : AC(2672)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963), NF-kappaB Inhibitor : CK(5952) : AC(3464), Nrf2 activation : CK(3156) : AC(1794)

Curcumin has a protective effect on experimentally induced inflammation, hepatotoxicity and cardiotoxicity in rats.

Pubmed Data : Exp Toxicol Pathol. 2010 Apr 2. Epub 2010 Apr 2. PMID: 20363603

Article Published Date : Apr 02, 2010

Authors : Suresh R Naik, Vishnu N Thakare, Snehal R Patil

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cardiovascular Diseases : CK(17333) : AC(2878), Inflammation : CK(16108) : AC(5498), Liver Damage: Drug-Induced : CK(651) : AC(285)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Cardioprotective : CK(9504) : AC(2963), Hepatoprotective : CK(8989) : AC(3831)

Curcumin has a protective role in cardiovascular diseases.

Pubmed Data : Int J Cardiol. 2009 Apr 3;133(2):145-51. Epub 2009 Feb 23. PMID: 19233493

Article Published Date : Apr 03, 2009

Authors : Wanwarang Wongcharoen, Arintaya Phrommintikul

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cardiovascular Diseases : CK(17333) : AC(2878)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Cardiovascular Agents : CK(215) : AC(35)

Curcumin has a wide range of potential anti-obesity properties.

Pubmed Data : Eur J Nutr. 2011 Apr ;50(3):151-61. Epub 2011 Mar 27. PMID: 21442412

Article Published Date : Apr 01, 2011

Authors : Adeeb Shehzad, Taewook Ha, Fazli Subhan, Young Sup Lee

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Metabolic Syndrome X : CK(3095) : AC(546), Obesity : CK(11004) : AC(2672)

Pharmacological Actions : Adiponectin upregulation : CK(229) : AC(41), Anti-Inflammatory Agents : CK(39737) : AC(15858), Leptin Down-Regulation : CK(23) : AC(8)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Curcumin has an anti-allergic effect through modulating mast cell-mediated allergic responses in allergic rhinitis.

Pubmed Data : Cell Immunol. 2015 Nov-Dec;298(1-2):88-95. Epub 2015 Sep 28. PMID: 26507910

Article Published Date : Oct 31, 2015

Authors : Ning Zhang, Hong Li, Jihui Jia, Mingqiang He

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Allergic Rhinitis : CK(1285) : AC(198), Allergies : CK(2000) : AC(406)

Pharmacological Actions : Anti-Allergic Agents : CK(598) : AC(221), Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin has an anti-inflammatory effect in macrophages stimulated by lipopolysaccharides from the periodontitis pathogen Porphyromonas gingivalis.

Pubmed Data : Pharmacology. 2008;82(4):264-9. Epub 2008 Oct 10. PMID: 18849645

Article Published Date : Jan 01, 2008

Authors : Dong Chen, Min Nie, Ming-Wen Fan, Zhuan Bian

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Inflammation : CK(16108) : AC(5498), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875), Periodontitis : CK(1328) : AC(311)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), NF-kappaB Inhibitor : CK(5952) : AC(3464), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin has anti-inflammatory properties in patients with postoperative inflammation.

Pubmed Data : Int J Clin Pharmacol Ther Toxicol. 1986 Dec;24(12):651-4. PMID: 3546166

Article Published Date : Dec 01, 1986

Authors : R R Satoskar, S J Shah, S G Shenoy

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Inflammation : CK(16108) : AC(5498), Postoperative Recovery : CK(596) : AC(74)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin has been demonstrated to be safe in six human trials and has demonstrated anti-inflammatory activity.

Pubmed Data : J Altern Complement Med. 2003 Feb;9(1):161-8. PMID: 12676044

Article Published Date : Feb 01, 2003

Authors : Nita Chainani-Wu

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cardiovascular Disease: Prevention : CK(8784) : AC(1467), Cardiovascular Diseases : CK(17333) : AC(2878), Chronic Kidney Disease (CKD) : CK(1186) : AC(211), Mitochondrial Dysfunction : CK(628) : AC(269)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antineoplastic Agents : CK(2235) : AC(1468), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Lipoxygenase Inhibitors : CK(50) : AC(27), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin has been evidence it possess both antimalarial activity and endothelial protection in vitro.

Pubmed Data : EXCLI J. 2014 ;13:287-99. Epub 2014 Mar 20. PMID: 26417261

Article Published Date : Dec 31, 2013

Authors : Sarun Kunwittaya, Lertyot Treeratanapiboon, Apapan Srisarin, Chartchalerm Isarankura-Na-Ayudhya, Virapong Prachayasittikul

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Malaria : CK(303) : AC(135)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360)

Curcumin has multiple molecular mechanisms as a chemopreventive.

Pubmed Data : AAPS J. 2006;8(3):E443-9. Epub 2006 Jul 7. PMID: 17025261

Article Published Date : Jan 01, 2006

Authors : Rajesh L Thangapazham, Anuj Sharma, Radha K Maheshwari

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anticarcinogenic Agents : CK(2152) : AC(1018), Chemopreventive : CK(6580) : AC(2166), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin has potential for treatment of heart disease in patients with established CKD by attenuating oxidative stress-related cardiac remodeling and mitochondrial dysfunction.

Pubmed Data : Cardiovasc Drugs Ther. 2015 Apr ;29(2):101-3. PMID: 25869394

Article Published Date : Mar 31, 2015

Authors : Elena N Dedkova

Study Type : Commentary

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963), Interleukin-6 Downregulation : CK(9337) : AC(3613), Nrf2 activation : CK(3156) : AC(1794), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin has significant anti-inflammatory, anti-oxidant and various other features which make it a strong candidate to be included in therapeutic armamentarium for treating CKD.

Pubmed Data : Molecules. 2014 ;19(12):20139-56. Epub 2014 Dec 2. PMID: 25474287

Article Published Date : Dec 31, 2013

Authors : Siddhartha S Ghosh, Todd W B Gehr, Shobha Ghosh

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Chronic Kidney Disease (CKD) : CK(1186) : AC(211), Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Renoprotective : CK(4544) : AC(1971)

Curcumin has strong antioxidant, with anti-inflammatory, immunomodulatory and analgesic properties.

Pubmed Data : Int J Pharm Investig. 2014 Jul ;4(3):138-41. PMID: 25126527

Article Published Date : Jun 30, 2014

Authors : Radha A Deshmukh, Anjana S Bagewadi

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Stomatitis: Aphthous : CK(293) : AC(36)

Pharmacological Actions : Analgesics : CK(9680) : AC(1472), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Immunomodulatory : CK(6531) : AC(2360)

Curcumin has the potential to induce and maintain remission in ulcerative colitis patients.

Pubmed Data : Acta Med Indones. 2017 Oct ;49(4):363-368. PMID: 29348389

Article Published Date : Sep 30, 2017

Authors : Marcellus Simadibrata, Christopher Christian Halimkesuma, Benedicta Mutiara Suwita

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Ulcerative Colitis : CK(1411) : AC(447)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin has therapeutic value in inflammatory bowel disease.

Pubmed Data : Inflamm Bowel Dis. 2011 Feb;17(2):503-15. PMID: 20629184

Article Published Date : Feb 01, 2011

Authors : C B Larmonier, M T Midura-Kiela, R Ramalingam, D Laubitz, N Janikashvili, N Larmonier, F K Ghishan, P R Kiela

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Inflammatory Bowel Diseases : CK(3196) : AC(926)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin has value as an add=on therapy in patients with bronchial asthma.

Pubmed Data : J Clin Diagn Res. 2014 Aug ;8(8):HC19-24. Epub 2014 Aug 20. PMID: 25302215

Article Published Date : Jul 31, 2014

Authors : Afroz Abidi, Surabhi Gupta, Manu Agarwal, H L Bhalla, Mahip Saluja

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Bronchial Asthma : CK(3250) : AC(721)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin improves bone microarchitecture and enhances mineral density in transgenic mice.

Pubmed Data : Phytomedicine. 2011 Jan 15;18(2-3):205-13. Epub 2010 Jul 16. PMID: 20637579

Article Published Date : Jan 15, 2011

Authors : Mao-Wei Yang, Tong-Hao Wang, Pei-Pei Yan, Li-Wei Chu, Jiang Yu, Zhi-Da Gao, Yuan-Zhou Li, Bao-Lei Guo

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Bone Fractures : CK(698) : AC(122), Osteopenia : CK(406) : AC(62), Osteoporosis : CK(2786) : AC(758)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin improves sclerosing cholangitis in mice.

Pubmed Data : Gut. 2010 Apr;59(4):521-30. PMID: 20332524

Article Published Date : Apr 01, 2010

Authors : Anna Baghdasaryan, Thierry Claudel, Astrid Kosters, Judith Gumhold, Dagmar Silbert, Andrea Thüringer, Katharina Leski, Peter Fickert, Saul J Karpen, Michael Trauner

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cholangitis : CK(16) : AC(4)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antiproliferative : CK(10001) : AC(7491)

Curcumin improves ulcerative proctitis and Crohn's disease in patient s with inflammatory bowel disease.

Pubmed Data : Dig Dis Sci. 2005 Nov;50(11):2191-3. PMID: 16240238

Article Published Date : Nov 01, 2005

Authors : Peter R Holt, Seymour Katz, Robert Kirshoff

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Inflammatory Bowel Diseases : CK(3196) : AC(926), Proctitis : CK(58) : AC(9), Proctocolitis: Ulcerative : CK(20) : AC(2)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin in combination with EPA and DHA work synergistically to reduce inflammation.

Pubmed Data : Biochem Pharmacol. 2010 Feb 1;79(3):421-30. Epub 2009 Sep 8. PMID: 19744468

Article Published Date : Feb 01, 2010

Authors : Constance Lay Lay Saw, Ying Huang, Ah-Ng Kong

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), DHA (Docosahexaenoic Acid) : CK(1285) : AC(244), EPA (Eicosapentaenoic Acid) : CK(1047) : AC(154)

Diseases : Cancers: All : CK(36404) : AC(14363), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antineoplastic Agents : CK(2235) : AC(1468), Antioxidants : CK(34551) : AC(14499)

Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

Curcumin in combination with visible light inhibits tumor growth in a xenograft tumor model.

Pubmed Data : Int J Cancer. 2009 Mar 15;124(6):1422-8. PMID: 19035461

Article Published Date : Mar 15, 2009

Authors : Jadranka Dujic, Stefan Kippenberger, Ana Ramirez-Bosca, Joaquin Diaz-Alperi, Jürgen Bereiter-Hahn, Roland Kaufmann, August Bernd, Matthias Hofmann

Study Type : Transgenic Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Epithelial Neoplasms: Malignant : CK(4) : AC(3)

Therapeutic Actions : Light Therapy : CK(818) : AC(141)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379)

Curcumin in ophthalmology: Mechanisms, challenges, and emerging opportunities.

Pubmed Data : Molecules. 2025 Jan 21 ;30(3). Epub 2025 Jan 21. PMID: 39942561

Article Published Date : Jan 20, 2025

Authors : Adriana Ribeiro, Daniele Oliveira, Helena Cabral-Marques

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Eye Diseases : CK(2669) : AC(713)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin in the correction of oxidative and immune disorders during exercises.

Pubmed Data : Vopr Pitan. 2021 ;90(1):65-73. Epub 2021 Jan 20. PMID: 33740329

Article Published Date : Dec 31, 2020

Authors : O A Gizinger, A A Khisamova

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Muscle Damage: Exercise-Induced : CK(1101) : AC(137)

Therapeutic Actions : Exercise : CK(6919) : AC(1026)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin in the treatment of inflammation and oxidative stress responses in traumatic brain injury.

Pubmed Data : Front Neurol. 2024 ;15:1380353. Epub 2024 May 10. PMID: 38798711

Article Published Date : Dec 31, 2023

Authors : Jinfeng Guo, Zhengjie Li, Yun Yao, Lei Fang, Mingdi Yu, Zuhui Wang

Study Type : Meta Analysis, Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain Injury: Traumatic : CK(383) : AC(131)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin induces programmed cell death and inhibits proinflammatory prostaglandin E2 production in synovial fibroblasts of patients with rheumatoid arthritis.

Pubmed Data : Int J Mol Med. 2007 Sep;20(3):365-72. PMID: 17671742

Article Published Date : Sep 01, 2007

Authors : Cheol Park, Dong-Oh Moon, Il-Whan Choi, Byung Tae Choi, Taek-Jeong Nam, Chung-Ho Rhu, Taeg Kyu Kwon, Won Ho Lee, Gi-Young Kim, Yung Hyun Choi

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Arthritis: Rheumatoid : CK(338) : AC(65), Rheumatoid Arthritis : CK(2322) : AC(562)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin inhibiting Th17 cell differentiation by regulating the metabotropic glutamate receptor-4 expression on dendritic cells.

Pubmed Data : Int Immunopharmacol. 2017 May ;46:80-86. PMID: 28273557

Article Published Date : Apr 30, 2017

Authors : Guangming Zhao, Ying Liu, Xiaying Yi, Yupeng Wang, Song Qiao, Zhen Li, Jing Ni, Zhiqi Song

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Autoimmune Diseases : CK(12040) : AC(2692), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360)

Curcumin inhibits BPA-induced insulin resistance by suppressing JNK pathway.

Pubmed Data : Biomed Pharmacother. 2018 Jan ;97:1538-1543. Epub 2017 Nov 21. PMID: 29793316

Article Published Date : Dec 31, 2017

Authors : Shanshan Geng, Shijia Wang, Weiwei Zhu, Chunfeng Xie, Xiaoting Li, Jieshu Wu, Jianyun Zhu, Ye Jiang, Xue Yang, Yuan Li, Yue Chen, Xiaoqian Wang, Yu Meng, Caiyun Zhong

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Bisphenol Toxicity : CK(4416) : AC(1329), Insulin Resistance : CK(4864) : AC(1098)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Problem Substances : Bisphenol A : CK(4570) : AC(1323)

Curcumin inhibits experimental collitis via anti-angiogenic and anti-inflammatory properties.

Pubmed Data : J Pharm Pharmacol. 2009 Mar;61(3):311-21. PMID: 19222903

Article Published Date : Mar 01, 2009

Authors : Vivek Ramshankar Yadav, Sarasija Suresh, Kshama Devi, Seema Yadav

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Colitis : CK(1542) : AC(735)

Pharmacological Actions : Anti-Angiogenic : CK(421) : AC(284), Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin inhibits gonorrhoeae-induced NF-kappaB signaling, release of pro-inflammatory cytokines/chemokines and attenuates adhesion in late infection.

Pubmed Data : Biol Chem. 2005 May;386(5):481-90. PMID: 15927892

Article Published Date : May 01, 2005

Authors : Silja Wessler, Petra Muenzner, Thomas F Meyer, Michael Naumann

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Gonorrhea : CK(16) : AC(6)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin inhibits HMGB1 releasing and attenuates concanavalin A-induced hepatitis in mice.

Pubmed Data : Eur J Pharmacol. 2012 Oct 11. Epub 2012 Oct 11. PMID: 23063543

Article Published Date : Oct 10, 2012

Authors : Chao Wang, Hao Nie, Kan Li, Yan-Xiang Zhang, Fei Yang, Cheng-Bin Li, Chang-Fu Wang, Quan Gong

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Hepatitis: Lectin-Induced (concanavalin) : CK(58) : AC(31)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831), High-mobility group box-1 (HMGB1) inhibitor : CK(2) : AC(1)

Curcumin inhibits inflammation associated with secretion of inflammatory chemokines.

Pubmed Data : Food Chem Toxicol. 2010 Jan;48(1):47-52. Epub 2009 Sep 18. PMID: 19766691

Article Published Date : Jan 01, 2010

Authors : Jun Hee Lim, Taeg Kyu Kwon

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antineoplastic Agents : CK(2235) : AC(1468), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin inhibits inflammatory cytokines and MMP-9 in primary gingival epithelial cells stimulated with P. gingivalis-derived lipopolysaccharide.

Pubmed Data : Odontology. 2019 May 13. Epub 2019 May 13. PMID: 31087163

Article Published Date : May 12, 2019

Authors : Seiko Toraya, Osamu Uehara, Daichi Hiraki, Fumiya Harada, Puja Neopane, Tetsuro Morikawa, Rie Takai, Koki Yoshida, Hirofumi Matsuoka, Nobuyoshi Kitaichi, Itsuo Chiba, Yoshihiro Abiko

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875), Porphyromonas gingivalis : CK(46) : AC(41)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(1141) : AC(720)

Curcumin inhibits lipopolysaccharide and lipoteichoic acid-induced expression of proinflammatory cytokines.

Pubmed Data : Mol Biol Rep. 2020 Dec ;47(12):10015-10021. Epub 2020 Nov 10. PMID: 33174083

Article Published Date : Nov 30, 2020

Authors : Ajaz Ali, Rouf Rashid Dar, Sheikh Firdous Ahmad, Sanjay Kumar Singh, Manas Kumar Patra, Manjit Panigrahi, Harendra Kumar, Narayanan Krishnaswamy

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Endometritis : CK(86) : AC(32), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Postaglandin PGE2 downregulation : CK(386) : AC(199)

Curcumin inhibits lipopolysaccharide-induced inflammation.

Pubmed Data : Int Immunopharmacol. 2010 Jul;10(7):760-8. Epub 2010 Apr 22. PMID: 20399909

Article Published Date : Jul 01, 2010

Authors : In Duk Jung, Young-Il Jeong, Chang-Min Lee, Kyung Tae Noh, Soo Kyung Jeong, Sung Hak Chun, Oksoon Hong Choi, Won Sun Park, Jin Han, Yong Kyoo Shin, Han Wool Kim, Cheol-Heui Yun, Yeong-Min Park

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Inflammation : CK(16108) : AC(5498), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Prostaglandin PGE2 downregulation : CK(194) : AC(89)

Curcumin inhibits lipoxygenase, indicating it possesses anti-inflammatory and anti-cancer properties.

Pubmed Data : Int J Mol Med. 2000 Nov;6(5):521-6. PMID: 11029517

Article Published Date : Nov 01, 2000

Authors : E Skrzypczak-Jankun, N P McCabe, S H Selman, J Jankun

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Chemopreventive : CK(6580) : AC(2166), Enzyme Inhibitors : CK(846) : AC(399), Lipoxygenase Inhibitors : CK(50) : AC(27)

Curcumin inhibits neuronal apoptosis and alleviates oxidative stress and inflammation in neurons subjected to Oxyhemoglobin.

Pubmed Data : Brain Res Bull. 2015 Nov 10 ;120:34-40. Epub 2015 Nov 10. PMID: 26551062

Article Published Date : Nov 09, 2015

Authors : Xia Li, Lei Zhao, Liang Yue, Haixiao Liu, Xiangmin Yang, Xinchuan Wang, Yan Lin, Yan Qu

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Subarachnoid hemorrhage : CK(206) : AC(72)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin inhibits the growth of breast cancer through the manipulation of the arachidonate metabolism.

Pubmed Data : BMC Cancer. 2007;7:138. Epub 2007 Jul 25. PMID: 17651499

Article Published Date : Jan 01, 2007

Authors : Rasha Hammamieh, Dena Sumaida, XiaoYan Zhang, Rina Das, Marti Jett

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Breast Cancer : CK(8297) : AC(3043), Cancers: Drug Resistant : CK(924) : AC(668)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase Inhibitors : CK(86) : AC(45), Lipoxygenase Inhibitors : CK(50) : AC(27)

Additional Keywords : Drug: Doxorubicin : CK(195) : AC(76)

Curcumin intake has some beneficial effects on the recovery of eccentric exercise induced muscle damage.

Pubmed Data : Eur J Appl Physiol. 2015 Sep ;115(9):1949-57. Epub 2015 Apr 29. PMID: 25921600

Article Published Date : Aug 31, 2015

Authors : Yoko Tanabe, Seiji Maeda, Nobuhiko Akazawa, Asako Zempo-Miyaki, Youngju Choi, Song-Gyu Ra, Atsushi Imaizumi, Yoshihiko Otsuka, Kazunori Nosaka

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Muscle Damage: Exercise-Induced : CK(1101) : AC(137)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin is a natural modulator of immune cells in systemic lupus erythematosus.

Pubmed Data : Autoimmun Rev. 2018 Feb ;17(2):125-135. Epub 2017 Nov 24. PMID: 29180127

Article Published Date : Jan 31, 2018

Authors : Amir Abbas Momtazi-Borojeni, Saeed Mohammadian Haftcheshmeh, Seyed-Alireza Esmaeili, Thomas P Johnston, Elham Abdollahi, Amirhossein Sahebkar

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Systemic Lupus Erythematosus : CK(817) : AC(139)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin is a potent antifibrotic agent and a promising treatment for diabetic nephropathy.

Pubmed Data : Biomed Res Int. 2017 ;2017:1516985. Epub 2017 Jan 17. PMID: 28194406

Article Published Date : Dec 31, 2016

Authors : Miaomiao Lu, Nanchang Yin, Wei Liu, Xiangfei Cui, Shuo Chen, Ermin Wang

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Diabetic Nephropathy : CK(1405) : AC(539)

Pharmacological Actions : Anti-Fibrotic : CK(2209) : AC(1052), Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Renoprotective : CK(4544) : AC(1971)

Curcumin is a potent therapeutic drug candidate for inflammatory and degenerative retinal and eye diseases.

Pubmed Data : Mol Nutr Food Res. 2013 Sep ;57(9):1557-68. Epub 2013 Feb 18. PMID: 23417969

Article Published Date : Aug 31, 2013

Authors : Lei-Lei Wang, Yue Sun, Kun Huang, Ling Zheng

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Diabetic Retinopathy : CK(483) : AC(211), Glaucoma : CK(611) : AC(145), Inflammation : CK(16108) : AC(5498), Macular Degeneration : CK(604) : AC(173), Retinal Diseases : CK(146) : AC(60)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin is a promising agent for neuropsychiatric disorders.

Pubmed Data : J Psychopharmacol. 2017 Mar ;31(3):287-302. Epub 2017 Jan 30. PMID: 28135888

Article Published Date : Feb 28, 2017

Authors : Adrian L Lopresti

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Autism : CK(965) : AC(165), Bipolar Disorder : CK(489) : AC(68), Obsessive-Compulsive Disorder : CK(422) : AC(78), Post-Traumatic Stress Disorders (PTSD) : CK(688) : AC(128)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Additional Keywords : Neuroprotective Agents : CK(20061) : AC(7949), Antioxidants : CK(303) : AC(126), Autism : CK(12) : AC(3), Autism : CK(12) : AC(3), CURCUMIN : CK(25) : AC(18), CURCUMIN : CK(25) : AC(18), CURCUMIN : CK(25) : AC(18), CURCUMIN : CK(25) : AC(18), CURCUMIN : CK(25) : AC(18)

Curcumin is a promising candidate for preventing and controlling migraine.

Pubmed Data : Biomed Pharmacother. 2023 Aug ;164:114910. Epub 2023 May 22. PMID: 37216708

Article Published Date : Jul 31, 2023

Authors : Hajar Heidari, Mehrnaz Shojaei, Gholamreza Askari, Muhammed Majeed, Mohammad Bagherniya, George E Barreto, Amirhossein Sahebkar

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Inflammation : CK(16108) : AC(5498), Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Analgesics : CK(9680) : AC(1472), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin is a promising ingredient of novel functional foods, with protective efficacy in preventing certain diseases.

Pubmed Data : Nutrients. 2018 Oct 19 ;10(10). Epub 2018 Oct 19. PMID: 30347782

Article Published Date : Oct 18, 2018

Authors : Xiao-Yu Xu, Xiao Meng, Sha Li, Ren-You Gan, Ya Li, Hua-Bin Li

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Animal Cancers : CK(19) : AC(15), Diabetes Mellitus: Type 2 : CK(12953) : AC(2579), Inflammation : CK(16108) : AC(5498), Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hypoglycemic Agents : CK(9221) : AC(2076), Immunomodulatory : CK(6531) : AC(2360), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin is effective in attenuating glial activation and ameliorates cognitive deficits in chronic epilepsy.

Pubmed Data : Neurochem Int. 2015 Jul 16. Epub 2015 Jul 16. PMID: 26190183

Article Published Date : Jul 15, 2015

Authors : Harpreet Kaur, Ishan Patro, Kulbhushan Tikoo, Rajat Sandhir

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain Inflammation : CK(1784) : AC(928), Cognitive Decline/Dysfunction : CK(5382) : AC(1059), Epilepsy : CK(1199) : AC(327)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin is effective in treating acute inflammation pain in the post-surgical removal of impacted third molars patients.

Pubmed Data : J Oral Rehabil. 2018 Jun 16. Epub 2018 Jun 16. PMID: 29908031

Article Published Date : Jun 15, 2018

Authors : Tantry Maulina, Hedy Diana, Arief Cahyanto, Amaliya

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Postoperative Recovery : CK(596) : AC(74)

Pharmacological Actions : Analgesics : CK(9680) : AC(1472), Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin loaded solid lipid nanoparticles ameliorate adjuvant-induced arthritis.

Pubmed Data : Eur J Pain. 2015 Aug ;19(7):940-52. Epub 2014 Nov 17. PMID: 25400173

Article Published Date : Jul 31, 2015

Authors : R Arora, A Kuhad, I P Kaur, K Chopra

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Arthritis : CK(5826) : AC(1505)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360)

curcumin may attenuate gentamicin induced nephrotoxicity.

Pubmed Data : Iran J Kidney Dis. 2022 Mar ;16(2):96-107. PMID: 35489078

Article Published Date : Feb 28, 2022

Authors : Duygu Uzun-Goren, Yesim Hulya Uz

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Chemotherapy-Induced Kidney Damage : CK(289) : AC(145), Chemotherapy-Induced Toxicity: Gentamicin : CK(194) : AC(102)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Chemoprotective Agents : CK(4278) : AC(1621), NF-kappaB Inhibitor : CK(5952) : AC(3464), Renoprotective : CK(4544) : AC(1971)

Curcumin may be a novel treatment for neuroinflammation-mediated neurodegenerative disorders.

Pubmed Data : Int J Mol Med. 2018 Jan ;41(1):521-530. Epub 2017 Oct 27. PMID: 29115589

Article Published Date : Dec 31, 2017

Authors : Meiling Jin, Sun Young Park, Qian Shen, Yihong Lai, Xingmei Ou, Zhuo Mao, Dongxu Lin, Yangyang Yu, Weizhen Zhang

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain Inflammation : CK(1784) : AC(928)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Heme oxygenase-1 inducer : CK(63) : AC(43), Nrf2 activation : CK(3156) : AC(1794)

Curcumin may be a potential treatment for preventing the harmful effects of phthalates.

Pubmed Data : Toxicol Appl Pharmacol. 2017 Aug 15 ;329:158-164. PMID: 28595985

Article Published Date : Aug 14, 2017

Authors : Satoru Sakuma, Maki Sumida, Yukiko Endoh, Ayaka Kurita, Ayana Yamaguchi, Tomoki Watanabe, Tetsuya Kohda, Yui Tsukiyama, Yohko Fujimoto

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Phthalate Toxicity : CK(1232) : AC(238)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Problem Substances : Phthalates : CK(1705) : AC(331)

Curcumin may be a promising agent to alleviate diabetic lung injury and also provides theoretical foundation for the development of diabetes therapy.

Pubmed Data : Clin Exp Pharmacol Physiol. 2015 Jun 26. Epub 2015 Jun 26. PMID: 26111829

Article Published Date : Jun 25, 2015

Authors : Fang Zhang, Fei Yang, Hongmei Zhao, Yunxia An

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Diabetes: Oxidative Stress : CK(635) : AC(244), Diabetic Complications : CK(4678) : AC(1606)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464), Nitric Oxide Inhibitor : CK(705) : AC(356), Postaglandin PGE2 downregulation : CK(386) : AC(199)

Curcumin may be a promising pharmacological candidate for neurodegenerative diseases.

Pubmed Data : PLoS One. 2016 ;11(1):e0147721. Epub 2016 Jan 29. PMID: 26824354

Article Published Date : Dec 31, 2015

Authors : Gen-Lin He, Zhen Luo, Ju Yang, Ting-Ting Shen, Yi Chen, Xue-Sen Yang

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210), Neurodegenerative Diseases : CK(13103) : AC(4279)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Prostaglandin PGE2 downregulation : CK(194) : AC(89)

Curcumin may be an alternative therapy for improving the outcomes of Benzo(a)pyrene-induced lung injury.

Pubmed Data : Molecules. 2020 Feb 7 ;25(3). Epub 2020 Feb 7. PMID: 32046055

Article Published Date : Feb 06, 2020

Authors : Saleh A Almatroodi, Faris Alrumaihi, Mohammed A Alsahli, Mazen Fahad Alhommrani, Arif Khan, Arshad Husain Rahmani

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Benzo[a]pyrene-induced Toxicity : CK(215) : AC(129), Lung Injury: Acute : CK(533) : AC(253)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Problem Substances : Benzo(a)pyrene : CK(184) : AC(108)

Curcumin may be considered as protective factor against inflammatory state of PCOS.

Pubmed Data : Cell J. 2017 Oct ;19(3):425-433. Epub 2017 Aug 19. PMID: 28836404

Article Published Date : Sep 30, 2017

Authors : Shima Mohammadi, Latifeh Karimzadeh Bardei, Vida Hojati, Azita Ghorbani Ghorbani, Mohammad Nabiuni

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Polycystic Ovary Syndrome : CK(2116) : AC(332)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831), Insulin Sensitizers : CK(1957) : AC(422), Interleukin-6 Downregulation : CK(9337) : AC(3613)

Curcumin may be effective against oxidative bowel damages induced in IBD by imbalanced gut immune response.

Pubmed Data : Int Immunopharmacol. 2012 Jan ;12(1):302-11. Epub 2011 Oct 29. PMID: 22036766

Article Published Date : Jan 01, 2012

Authors : Souad Mouzaoui, Ibtissem Rahim, Bahia Djerdjouri

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Colitis : CK(1542) : AC(735), Crohn's Disease : CK(242) : AC(55), Inflammatory Bowel Diseases : CK(3196) : AC(926)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin may be effective in alleviating dextran sulfate sodium-induced colitis by regulating Tfh differentiation.

Pubmed Data : Am J Chin Med. 2021 Dec 20:1-19. Epub 2021 Dec 20. PMID: 34931590

Article Published Date : Dec 19, 2021

Authors : Hai-Yan Wang, Wei Ge, Su-Qing Liu, Jian Long, Qing-Qing Jiang, Wen Zhou, Zheng-Yun Zuo, Duan-Yong Liu, Hai-Mei Zhao, You-Bao Zhong

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Colitis : CK(1542) : AC(735)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin may have a direct suppressive effect on intestinal mast cell activation and reverse food allergy symptoms in allergen-sensitized individuals.

Pubmed Data : PLoS One. 2015;10(7):e0132467. Epub 2015 Jul 6. PMID: 26147007

Article Published Date : Dec 31, 2014

Authors : Shannon R M Kinney, Logan Carlson, Jennifer Ser-Dolansky, Chelsea Thompson, Sagar Shah, Amos Gambrah, Wei Xing, Sallie S Schneider, Clinton B Mathias

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Anaphylaxis : CK(153) : AC(40), Food Allergies : CK(768) : AC(133), Mastocytosis : CK(5) : AC(2)

Pharmacological Actions : Anti-Allergic Agents : CK(598) : AC(221), Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Additional Keywords : Significant Treatment Outcome : CK(4297) : AC(505)

Curcumin may have therapeutic potential for bladder cancer patients via anti-inflammatory, antioxidant and anti-carcinogenic activities.

Pubmed Data : Oncol Rep. 2006 May;15(5):1225-31. PMID: 16596191

Article Published Date : May 01, 2006

Authors : Cheol Park, Gi Young Kim, Gun Do Kim, Byung Tae Choi, Yeong-Min Park, Yung Hyun Choi

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)

Diseases : Bladder Cancer : CK(782) : AC(320)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anticarcinogenic Agents : CK(2152) : AC(1018), Antioxidants : CK(34551) : AC(14499)

Curcumin may have therapeutic value in inflammatory conditions of the central nervous system.

Pubmed Data : J Neuroinflammation. 2005 Feb 25;2(1):8. Epub 2005 Feb 25. PMID: 15733321

Article Published Date : Feb 25, 2005

Authors : Michiyo Tomita, Brita J Holman, Christopher P Santoro, Thomas J Santoro

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain Inflammation : CK(1784) : AC(928)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin may offer a viable alternative for the prevention or control of HIV replication in the female genital tract.

Pubmed Data : PLoS One. 2015 ;10(4):e0124903. Epub 2015 Apr 9. PMID: 25856395

Article Published Date : Dec 31, 2014

Authors : Victor H Ferreira, Aisha Nazli, Sara E Dizzell, Kristen Mueller, Charu Kaushic

Study Type : Human In Vitro

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Herpes Simplex Virus Type 2 : CK(93) : AC(70), HIV Infections : CK(1193) : AC(399), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anti-Retroviral Agents : CK(51) : AC(20), Antiviral Agents : CK(3095) : AC(1702), Interleukin-6 Downregulation : CK(9337) : AC(3613), Interleukin-8 downregulation : CK(1107) : AC(402), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin may offer protective effects against methotrexate-induced rat enteritis by lowering the intestinal mucosal permeability.

Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2008 Jan;28(1):119-21. PMID: 18227041

Article Published Date : Jan 01, 2008

Authors : Wei-Bing Song, Zhen-Shu Zhang, Bing Xiao

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Drug Toxicity: Methotrexate : CK(194) : AC(100), Gastroenteritis : CK(186) : AC(29), Intestinal Permeability : CK(249) : AC(63)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin may protect against amyloid-beta-stimulated inflammation associated wtih Alzheimer disease.

Pubmed Data : J Alzheimers Dis. 2010;20(4):1189-99. PMID: 20413894

Article Published Date : Jan 01, 2010

Authors : Hong-Mei Wang, Yan-Xin Zhao, Shi Zhang, Gui-Dong Liu, Wen-Yan Kang, Hui-Dong Tang, Jian-Qing Ding, Sheng-Di Chen

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210), Brain Inflammation : CK(1784) : AC(928), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin may reduce inflammation in the pancreas.

Pubmed Data : Mol Biol Rep. 2009 Nov;36(8):2329-32. Epub 2009 Jan 21. PMID: 19156536

Article Published Date : Nov 01, 2009

Authors : Keynoosh Khalooghi, Saeid Hashemi, Nahid Mehraban, Parvin Amiri, Javad Tavakkoly Bazzaz, Bagher Larijani, Mahsa M Amoli

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875), Pancreatitis : CK(500) : AC(186)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin may represent a novel therapeutic agent targeting endothelial activation in inflammatory bowel disease.

Pubmed Data : Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G259-68. Epub 2009 Jun 11. PMID: 19520742

Article Published Date : Aug 01, 2009

Authors : David G Binion, Jan Heidemann, Mona S Li, Victoria M Nelson, Mary F Otterson, Parvaneh Rafiee

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Inflammatory Bowel Diseases : CK(3196) : AC(926), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806), Vascular Cell Adhesion Molecule-1 Inhibitor : CK(126) : AC(37)

Curcumin may stimulate recovery from spinal cord injury.

Pubmed Data : J Neurosurg Spine. 2012 Feb 10. Epub 2012 Feb 10. PMID: 22324804

Article Published Date : Feb 10, 2012

Authors : D Ryan Ormond, Hong Peng, Richard Zeman, Kaushik Das, Raj Murali, Meena Jhanwar-Uniyal

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Spinal Cord Injuries : CK(890) : AC(347)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Regenerative Substances : CK(45) : AC(21)

Curcumin may support the regeneration of articular cartilage.

Pubmed Data : Arthritis Res Ther. 2010;12(4):R127. Epub 2010 Jul 1. PMID: 20594343

Article Published Date : Jan 01, 2010

Authors : Constanze Buhrmann, Ali Mobasheri, Ulrike Matis, Mehdi Shakibaei

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cartilage Diseases : CK(10) : AC(8), Osteoarthritis : CK(2225) : AC(627), Rheumatoid Arthritis : CK(2322) : AC(562)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Apoptotic : CK(9585) : AC(7379), Interleukin-1 beta downregulation : CK(6063) : AC(2940), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin mediates anticancer effects by modulating multiple cell signaling pathways.

Pubmed Data : Clin Sci (Lond). 2017 Aug 1 ;131(15):1781-1799. Epub 2017 Jul 5. PMID: 28679846

Article Published Date : Jul 31, 2017

Authors : Ajaikumar B Kunnumakkara, Devivasha Bordoloi, Choudhary Harsha, Kishore Banik, Subash C Gupta, Bharat B Aggarwal

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cancers: All : CK(36404) : AC(14363)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antiproliferative : CK(10001) : AC(7491), Chemosensitizer : CK(1657) : AC(1270), Chemotherapeutic : CK(4390) : AC(1635), Radiosensitizer : CK(372) : AC(247)

Additional Keywords : Natural Substance/Drug Synergy : CK(1526) : AC(720)

Curcumin mediates IL-6/STAT3 signaling pathway to repair intestinal mucosal injury induced by 5-FU chemotherapy for colon cancer.

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2021 Feb ;46(3):670-677. PMID: 33645034

Article Published Date : Jan 31, 2021

Authors : Lu Xu, Xian Wang, Xuan-Ying Wang, Qing-Hua Yao, Yin-Bo Chen

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Chemotherapy-Induced Toxicity: 5-fluorouracil : CK(191) : AC(85), Colon Cancer : CK(1920) : AC(1203)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Chemoprotective Agents : CK(4278) : AC(1621), Interleukin-6 Downregulation : CK(9337) : AC(3613)

Curcumin metabolite tetrahydrocurcumin in the treatment of eye diseases.

Pubmed Data : Int J Mol Sci. 2020 Dec 28 ;22(1). Epub 2020 Dec 28. PMID: 33379248

Article Published Date : Dec 27, 2020

Authors : Yu-Wen Kao, Sheng-Kai Hsu, Jeff Yi-Fu Chen, I-Ling Lin, Kuo-Jen Chen, Po-Yen Lee, Hui-Suan Ng, Chien-Chih Chiu, Kai-Chun Cheng

Study Type : Review

Additional Links

Substances : Tetrahydrocurcumin : CK(173) : AC(99)

Diseases : Eye Diseases : CK(2669) : AC(713)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin might be useful in the chemoprevention of colorectal cancer in individuals consuming an high-protein diet.

Pubmed Data : Nutr Res. 2015 Aug ;35(8):726-35. Epub 2015 Jun 1. PMID: 26094212

Article Published Date : Jul 31, 2015

Authors : So-Young Byun, Dan-Bi Kim, Eunjung Kim

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Colorectal Cancer: Prevention : CK(263) : AC(48), Gastrointestinal Inflammation : CK(330) : AC(157)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anticarcinogenic Agents : CK(2152) : AC(1018), Chemopreventive : CK(6580) : AC(2166), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Nitric Oxide Inhibitor : CK(705) : AC(356), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin might prevent early bacterial or virus infection into the lumen of the intestine or reduce the degree of the infection by inhibiting the inflammatory response.

Pubmed Data : Nutr Res Pract. 2015 Apr ;9(2):117-22. Epub 2015 Mar 6. PMID: 25861416

Article Published Date : Mar 31, 2015

Authors : Jin Ah Cho, Eunmi Park

Study Type : Human In Vitro, In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cholera : CK(93) : AC(45), Gastrointestinal Infections : CK(36) : AC(5), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Bacterial Agents : CK(4228) : AC(1989), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antiviral Agents : CK(3095) : AC(1702), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin mitigates muscle atrophy.

Pubmed Data : Curr Issues Mol Biol. 2024 Nov 5 ;46(11):12497-12511. Epub 2024 Nov 5. PMID: 39590336

Article Published Date : Nov 04, 2024

Authors : Casey Appell, Nigel C Jiwan, Chwan-Li Shen, Hui-Ying Luk

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Muscle Atrophy : CK(292) : AC(124)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin modulates astrocyte function under basal and inflammatory conditions.[

Pubmed Data : Brain Res. 2023 Nov 1 ;1818:148519. Epub 2023 Aug 9. PMID: 37562565

Article Published Date : Oct 31, 2023

Authors : Marina Seady, Fernanda Telles Fróes, Carlos Alberto Gonçalves, Marina Concli Leite

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210), Inflammation : CK(16108) : AC(5498), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin modulates PTPRZ1 activity and RNA m6A modifications in neuroinflammation-associated microglial response.

Pubmed Data : Adv Sci (Weinh). 2025 Feb 8:e2405263. Epub 2025 Feb 8. PMID: 39921492

Article Published Date : Feb 07, 2025

Authors : Ninan Zhang, Ruifan Lin, Wenya Gao, Honglin Xu, Yuejia Li, Xiahe Huang, Yingchun Wang, Xianghong Jing, Wenxiang Meng, Qi Xie

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain Inflammation : CK(1784) : AC(928)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin modulates the immune response associated with LPS-induced periodontal disease in rats, indicating its potential therapeutic value.

Pubmed Data : Innate Immun. 2011 Jan 17. Epub 2011 Jan 17. PMID: 21242275

Article Published Date : Jan 17, 2011

Authors : Morgana Rodrigues Guimarães, Sabrina Garcia de Aquino, Leila S Coimbra, Luis Carlos Spolidorio, Keith L Kirkwood, Carlos Rossa

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875), Periodontal Diseases : CK(808) : AC(203)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin mouthwash is well tolerated and effective in controlling the signs and symptoms of Radio-chemotherapy induced oral mucositis.

Pubmed Data : J Clin Diagn Res. 2015 Aug ;9(8):ZC59-62. Epub 2015 Aug 1. PMID: 26436049

Article Published Date : Jul 31, 2015

Authors : Karthikeya Patil, Mahima V Guledgud, P K Kulkarni, Deepika Keshari, Srishti Tayal

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Radiation Induced Illness: Mucositis : CK(348) : AC(44), Wound Healing : CK(4555) : AC(1412)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Chemical: Chlorhexidine : CK(51) : AC(6), Natural Substances Versus Chemicals : CK(61) : AC(7), Significant Treatment Outcome : CK(4297) : AC(505)

Curcumin nanoformulations to combat aging-related diseases.

Pubmed Data : Ageing Res Rev. 2021 May 14 ;69:101364. Epub 2021 May 14. PMID: 34000462

Article Published Date : May 13, 2021

Authors : Maryam Mahjoob, Ursula Stochaj

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Aging : CK(6221) : AC(1510)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin nanoparticles alleviate brain mitochondrial dysfunction and cellular senescence in γ-irradiated rats.

Pubmed Data : Sci Rep. 2025 Jan 31 ;15(1):3857. Epub 2025 Jan 31. PMID: 39890961

Article Published Date : Jan 30, 2025

Authors : Omnia A Moselhy, Nahed Abdel-Aziz, Azza El-Bahkery, Said S Moselhy, Ehab A Ibrahim

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Lipid Peroxidation : CK(2057) : AC(806), Oxidative Stress : CK(14758) : AC(5716), Radiation Induced Illness : CK(1352) : AC(366)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin nanoparticles have the capacity to mitigate the renal toxicity induced by aluminum oxide nanoparticles.

Pubmed Data : Environ Toxicol. 2024 Aug 6. Epub 2024 Aug 6. PMID: 39105312

Article Published Date : Aug 05, 2024

Authors : Ehab Tousson, Ibrahim E T El-Sayed, Hebatalla Nashaat Elsharkawy, Amira S Ahmed

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Aluminum Toxicity : CK(735) : AC(318)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Renoprotective : CK(4544) : AC(1971)

Problem Substances : Aluminum oxide : CK(20) : AC(10)

Curcumin oil has a protective effect against cisplatin-induced nephrotoxicity.

Pubmed Data : J Agric Food Chem. 2007 Dec 12;55(25):10150-5. Epub 2007 Nov 15. PMID: 18001039

Article Published Date : Dec 12, 2007

Authors : Anurag Kuhad, Sangeeta Pilkhwal, Sameer Sharma, Naveen Tirkey, Kanwaljit Chopra

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1246) : AC(601), Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Renoprotective : CK(4544) : AC(1971), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin on human health: A comprehensive systematic review and meta-analysis of 103 randomized controlled trials.

Pubmed Data : Phytother Res. 2024 Oct 31. Epub 2024 Oct 31. PMID: 39478418

Article Published Date : Oct 30, 2024

Authors : Ali Jafari, Maryam Abbastabar, Alireza Alaghi, Javad Heshmati, Francesca L Crowe, Mahdi Sepidarkish

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hypoglycemic Agents : CK(9221) : AC(2076), Hypolipidemic : CK(9173) : AC(2038)

Curcumin possesses anti-diabetic effects and mitigates diabetes complications

Pubmed Data : Curr Top Med Chem. 2015 Jun 19. Epub 2015 Jun 19. PMID: 26088351

Article Published Date : Jun 18, 2015

Authors : Seyed Fazel Nabavi, Raman Thiagarajan, Luca Rastrelli, Maria Daglia, Eduardo Sobarzo-Sanchez, Heshmatollah Alinezhad, Seyed Mohammad Nabavi

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Diabetes Mellitus: Type 2 : CK(12953) : AC(2579), Diabetic Complications : CK(4678) : AC(1606)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Additional Keywords : Advanced Glycation End Products : CK(11) : AC(2)

Curcumin potentially modulates activation of dendritic cells and promotes the recovery of damaged colonic mucosa in IBD.

Pubmed Data : World J Gastroenterol. 2016 Jun 21 ;22(23):5374-83. PMID: 27340353

Article Published Date : Jun 20, 2016

Authors : Hai-Mei Zhao, Rong Xu, Xiao-Ying Huang, Shao-Min Cheng, Min-Fang Huang, Hai-Yang Yue, Xin Wang, Yong Zou, Ai-Ping Lu, Duan-Yong Liu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Colitis : CK(1542) : AC(735), Inflammatory Bowel Diseases : CK(3196) : AC(926)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma.

Pubmed Data : Onco Targets Ther. 2017 ;10:5471-5482. Epub 2017 Nov 15. PMID: 29180881

Article Published Date : Dec 31, 2016

Authors : Jun Zhao, Jiabin Zhu, Xiaoshu Lv, Jinshan Xing, Shuang Liu, Chen Chen, Yinghui Xu

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Glioblastoma : CK(729) : AC(403)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Chemotherapeutic : CK(4390) : AC(1635), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin potently inhibits the activation of NLRP3 inflammasome which may contribute to its anti-inflammatory activity.

Pubmed Data : Mol Nutr Food Res. 2015 Aug 7. Epub 2015 Aug 7. PMID: 26250869

Article Published Date : Aug 06, 2015

Authors : Zizhen Gong, Jiefei Zhou, Hui Li, Yanhong Gao, Congfeng Xu, Shengnan Zhao, Yingwei Chen, Wei Cai, Jin Wu

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Inflammation : CK(16108) : AC(5498), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940)

Curcumin prevents chemically-induced colitis.

Pubmed Data : Scand J Gastroenterol. 2009;44(2):187-94. PMID: 18830899

Article Published Date : Jan 01, 2009

Authors : Asmaa S Lubbad, Mabayoje A Oriowo, Islam Khan

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Colitis : CK(1542) : AC(735)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin prevents diabetic osteoporosis through promoting osteogenesis and angiogenesis.

Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:4974343. Epub 2022 Nov 7. PMID: 36387354

Article Published Date : Dec 31, 2021

Authors : Desheng Fan, Jiuqing Lu, Nijia Yu, Yajia Xie, Lei Zhen

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Osteoporosis : CK(2786) : AC(758)

Pharmacological Actions : Angiogenesis Inhibitors : CK(724) : AC(481), Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin prevents human aortic smooth muscle cells migration associated with the development atherosclerosis.

Pubmed Data : Nutr Metab Cardiovasc Dis. 2010 Feb;20(2):125-32. Epub 2009 May 17. PMID: 19447587

Article Published Date : Feb 01, 2010

Authors : Y-M Yu, H-C Lin

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Atherosclerosis : CK(2063) : AC(778)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(944) : AC(588), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin promotes oligodendrocyte differentiation and their protection against TNF-α through the activation of the nuclear receptor PPAR-γ.

Pubmed Data : Sci Rep. 2021 Mar 2 ;11(1):4952. Epub 2021 Mar 2. PMID: 33654147

Article Published Date : Mar 01, 2021

Authors : Antonietta Bernardo, Cristina Plumitallo, Chiara De Nuccio, Sergio Visentin, Luisa Minghetti

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin protected the liver from chronic-ethanol induced injury through attenuating oxidative stress

Pubmed Data : Pharmacogn Mag. 2015 Oct-Dec;11(44):707-715. PMID: 26600714

Article Published Date : Sep 30, 2015

Authors : Zhang E Xiong, Wei Guo Dong, Bao Ying Wang, Qiao Yun Tong, Zhong Yan Li

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Alcoholic Liver Disease : CK(611) : AC(283)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Nrf2 activation : CK(3156) : AC(1794)

Curcumin protects against intestinal origin endotoxemia in rat liver cirrhosis.

Pubmed Data : J Food Sci. 2017 Feb 14. Epub 2017 Feb 14. PMID: 28196290

Article Published Date : Feb 13, 2017

Authors : Yu Cai, Di Lu, Yanting Zou, Chaohui Zhou, Hongchun Liu, Chuantao Tu, Feng Li, Lili Liu, Shuncai Zhang

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Liver Cirrhosis : CK(919) : AC(230)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Additional Keywords : Gene Expression Regulation : CK(1401) : AC(623)

Curcumin protects against MSG-induced neurotoxicity in rats.

Pubmed Data : Neurosignals. 2016 Aug 17 ;24(1):81-87. Epub 2016 Aug 17. PMID: 27529496

Article Published Date : Aug 16, 2016

Authors : Rania M Khalil, Naglaa F Khedr

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : MSG Toxicity : CK(16) : AC(8)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Problem Substances : Monosodium Glutamate (MSG) : CK(265) : AC(107)

Curcumin protects astrocytes from induced oxidative stress, and reverses mitochondrial damage and dysfunction induced by oxidative stress.

Pubmed Data : Neuroscience. 2016 Jul 13. Epub 2016 Jul 13. PMID: 27423629

Article Published Date : Jul 12, 2016

Authors : Amita Daverey, Sandeep K Agrawal

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Mitochondrial Dysfunction : CK(628) : AC(269), Neurodegenerative Diseases : CK(13103) : AC(4279), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Cytoprotective : CK(809) : AC(401), Neuroprotective Agents : CK(20061) : AC(7949), Regenerative : CK(486) : AC(201)

Curcumin protects dopaminergic neuron against lipopolysaccharide induced neurotoxicity.

Pubmed Data : Neurochem Res. 2008 Oct;33(10):2044-53. Epub 2008 Mar 27. PMID: 18368483

Article Published Date : Oct 01, 2008

Authors : Sufen Yang, Dan Zhang, Zhengqin Yang, Xiaoming Hu, Steven Qian, Jie Liu, Belinda Wilson, Michelle Block, Jau-Shyong Hong

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain: Microglial Activation : CK(205) : AC(118), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875), Neurodegenerative Diseases : CK(13103) : AC(4279)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Neuroprotective Agents : CK(20061) : AC(7949), NF-kappaB Inhibitor : CK(5952) : AC(3464), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin protects effects against cerebral I/R injury through the activation of JAK2/STAT3 signaling pathway.

Pubmed Data : Int J Clin Exp Med. 2015;8(9):14985-14991. Epub 2015 Sep 15. PMID: 26628981

Article Published Date : Dec 31, 2014

Authors : Linlin Li, Haiyong Li, Mingming Li

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cerebral Ischemia : CK(1183) : AC(566)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-8 downregulation : CK(1107) : AC(402), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin protects glial cells and promotes a microglial anti-inflammatory phenotype by a mechanism that implicates HO-1 induction.

Pubmed Data : Mol Nutr Food Res. 2015 Sep ;59(9):1690-700. Epub 2015 Jun 30. PMID: 26047311

Article Published Date : Aug 31, 2015

Authors : Esther Parada, Izaskun Buendia, Elisa Navarro, Carlos Avendaño, Javier Egea, Manuela G López

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain: Oxidative Stress : CK(644) : AC(347), Brain Inflammation : CK(1784) : AC(928)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin protects intestinal mucosal barrier function of rat enteritis.

Pubmed Data : PLoS One. 2010;5(9):e12969. Epub 2010 Sep 24. PMID: 20885979

Article Published Date : Jan 01, 2010

Authors : Wei-Bing Song, Yuan-Yuan Wang, Fan-Su Meng, Qing-Hua Zhang, Jian-Ying Zeng, Li-Ping Xiao, Xin-Pei Yu, Dan-dan Peng, Lei Su, Bing Xiao, Zhen-Shu Zhang

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Intestinal Permeability : CK(249) : AC(63)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Gastroprotective : CK(1692) : AC(701)

Curcumin protects mice from P. acnes-induced liver injury through reduction of HMGB1 cytoplasmic translocation and expression.

Pubmed Data : Int Immunopharmacol. 2015 Feb ;24(2):159-65. Epub 2014 Dec 13. PMID: 25510585

Article Published Date : Jan 31, 2015

Authors : Qiaoli Gu, Honggeng Guan, Qin Shi, Yanyun Zhang, Huilin Yang

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Acne : CK(943) : AC(168), Gram-Negative Bacterial Infections : CK(135) : AC(99)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831)

Curcumin protects the rat liver from chemically-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation.

Pubmed Data : Mol Pharmacol. 2008 Feb;73(2):399-409. Epub 2007 Nov 15. PMID: 18006644

Article Published Date : Feb 01, 2008

Authors : Yumei Fu, Shizhong Zheng, Jianguo Lin, Jan Ryerse, Anping Chen

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Inflammation : CK(16108) : AC(5498), Liver Fibrosis : CK(882) : AC(399), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin reduced or eliminated colonic tumor burden with limited effects on mucosal immune responses.

Pubmed Data : Inflamm Bowel Dis. 2015 Jul 25. Epub 2015 Jul 25. PMID: 26218141

Article Published Date : Jul 24, 2015

Authors : Rita-Marie T McFadden, Claire B Larmonier, Kareem W Shehab, Monica Midura-Kiela, Rajalakshmy Ramalingam, Christy A Harrison, David G Besselsen, John H Chase, J Gregory Caporaso, Christian Jobin, Fayez K Ghishan, Pawel R Kiela

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Colitis : CK(1542) : AC(735), Colon Cancer: Prevention : CK(192) : AC(64)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anticarcinogenic Agents : CK(2152) : AC(1018), Antioxidants : CK(34551) : AC(14499), Chemopreventive : CK(6580) : AC(2166)

Additional Keywords : Microbiota : CK(1256) : AC(346)

Curcumin reduces adjuvant-induced c-reactive protein and inflammation.

Pubmed Data : Immunopharmacol Immunotoxicol. 2003 May;25(2):213-24. PMID: 12784914

Article Published Date : May 01, 2003

Authors : Manish Banerjee, L M Tripathi, V M L Srivastava, Anju Puri, Rakesh Shukla

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : C-Reactive Protein : CK(3950) : AC(392), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin reduces development of seizurelike events

Pubmed Data : Epilepsia. 2019 Feb 12. Epub 2019 Feb 12. PMID: 30747999

Article Published Date : Feb 11, 2019

Authors : Cato M Drion, Lieneke Kooijman, Eleonora Aronica, Erwin A van Vliet, Wytse J Wadman, Pascal Chameau, Jan A Gorter

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Epilepsy : CK(1199) : AC(327)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anticonvulsants : CK(1163) : AC(299), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613)

Curcumin reduces intestinal inflammation and polyps, indicating its potential value for preventing colon cancer.

Pubmed Data : J Interferon Cytokine Res. 2010 Oct 15. Epub 2010 Oct 15. PMID: 20950131

Article Published Date : Oct 15, 2010

Authors : E Angela Murphy, J Mark Davis, Jamie L McClellan, Benjamin T Gordon, Martin D Carmichael

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Colon Cancer : CK(1920) : AC(1203), Gastrointestinal Inflammation : CK(330) : AC(157), Intestinal Cancer : CK(36) : AC(10), Intestinal Polyps : CK(22) : AC(11)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin reduces lung inflammation via Wnt/β-catenin signaling in mouse model of asthma.

Pubmed Data : J Asthma. 2017 May ;54(4):335-340. Epub 2016 Aug 15. PMID: 27715343

Article Published Date : Apr 30, 2017

Authors : Xia Yang, Jian-Ning Lv, Hui Li, Bo Jiao, Qiu-Hong Zhang, Yong Zhang, Jie Zhang, Yan-Qin Liu, Ming Zhang, Hu Shan, Jin-Zhao Zhang, Run-Miao Wu, Ya-Li Li

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Asthma : CK(3242) : AC(707)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Wnt/β-catenin signaling pathway modulation : CK(330) : AC(224)

Curcumin reduces nitric oxide formation and associated inflammation in the rat mammary gland.

Pubmed Data : J Exp Biol. 2009 Jan;212(Pt 2):163-8. PMID: 11020339

Article Published Date : Jan 01, 2009

Authors : M Onoda, H Inano

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Breast Cancer : CK(8297) : AC(3043), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antineoplastic Agents : CK(2235) : AC(1468), Antioxidants : CK(34551) : AC(14499), Nitric Oxide Inhibitor : CK(705) : AC(356)

Curcumin reduces production of ROS and inflammatory mediators in HIV-1-gp120-stimulated microglia, and protects cortical neurons against HIV-1-mediated apoptosis.

Pubmed Data : PLoS One. 2013 ;8(8):e70565. Epub 2013 Aug 6. PMID: 23936448

Article Published Date : Dec 31, 2012

Authors : Luyan Guo, Yanyan Xing, Rui Pan, Mingliang Jiang, Zheng Gong, Liqing Lin, Junbing Wang, Guoyin Xiong, Jun Dong

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : HIV Infections : CK(1193) : AC(399), Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin regulates the shift from Th1 to Th2 in trinitrobenzene sulphonic acid-induced chronic colitis.

Pubmed Data : Acta Pharmacol Sin. 2006 Aug;27(8):1071-7. PMID: 16867261

Article Published Date : Aug 01, 2006

Authors : Ming Zhang, Chang-Sheng Deng, Jia-Ju Zheng, Jian Xia

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Colitis : CK(1542) : AC(735), Immune Dysregulation: TH1 dominance : CK(39) : AC(9)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin relieved the rheumatoid arthritis progression via modulating the linc00052/miR-126-5p/PIAS2 axis.

Pubmed Data : Bioengineered. 2022 Apr ;13(4):10973-10983. PMID: 35473503

Article Published Date : Mar 31, 2022

Authors : Jianwei Xiao, Xu Cai, Weijian Zhou, Rongsheng Wang, Zhizhong Ye

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Rheumatoid Arthritis : CK(2322) : AC(562)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), MicroRNA modulator : CK(1560) : AC(897)

Curcumin relieves a depressive-like state through the inhibition of the NLRP3 inflammasome and kynurenine pathway.

Pubmed Data : Int Immunopharmacol. 2018 Dec 10 ;67:138-144. Epub 2018 Dec 10. PMID: 30551030

Article Published Date : Dec 09, 2018

Authors : Wen-Yuan Zhang, Yu-Jin Guo, Wen-Xiu Han, Meng-Qi Yang, Lu-Ping Wen, Ke-Yi Wang, Pei Jiang

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Depression : CK(9574) : AC(1756)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin represents grounds for optimism in terms of anti-inflammatory treatment in acute otitis media.

Pubmed Data : J Craniofac Surg. 2016 Jul 1. Epub 2016 Jul 1. PMID: 27380582

Article Published Date : Jun 30, 2016

Authors : Servet Akyuz, Fatih Turan, Levent Gurbuzler, Akgül Arici, Erkan Sogut, Ozalkan Ozkan

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Otitis media : CK(426) : AC(64)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Malondialdehyde Down-regulation : CK(3028) : AC(992)

Curcumin restores innate immune Alzheimer's disease risk gene expression to ameliorate Alzheimer pathogenesis.

Pubmed Data : Neurobiol Dis. 2019 07 ;127:432-448. Epub 2019 Apr 2. PMID: 30951849

Article Published Date : Dec 31, 2018

Authors : B Teter, T Morihara, G P Lim, T Chu, M R Jones, X Zuo, R M Paul, S A Frautschy, G M Cole

Study Type : Transgenic Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Immunomodulatory : CK(6531) : AC(2360), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin significantly ameliorates disease symptoms in a Drosophila model of Huntington's disease.

Pubmed Data : Sci Rep. 2016 ;6:18736. Epub 2016 Jan 5. PMID: 26728250

Article Published Date : Dec 31, 2015

Authors : Anjalika Chongtham, Namita Agrawal

Study Type : Insect Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Huntington Disease : CK(222) : AC(103)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin significantly inhibited the formation of advanced glycation end products (AGEs).

Pubmed Data : Mol Med Rep. 2015 Dec 28. Epub 2015 Dec 28. PMID: 26718010

Article Published Date : Dec 27, 2015

Authors : Yan Ping Sun, Jun Fei Gu, Xiao Bin Tan, Chun Fei Wang, Xiao Bin Jia, Liang Feng, Ji Ping Liu

Study Type : Human In Vitro

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Advanced Glycation End products (AGE) : CK(589) : AC(249), Endothelial Dysfunction : CK(2733) : AC(581), Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Glycation Agents : CK(351) : AC(167), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin significantly inhibited the production of pro-inflammatory cytokine IL-18 in E.coli LPS stimulated murine macrophage-like cells.

Pubmed Data : Indian J Clin Biochem. 2015 Jan ;30(1):109-12. Epub 2014 Jul 15. PMID: 25646051

Article Published Date : Dec 31, 2014

Authors : Renu Yadav, Babban Jee, Sudhir Kumar Awasthi

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-18 down-regulation : CK(372) : AC(183)

Additional Keywords : Dose Response : CK(1770) : AC(700)

Curcumin significantly reduced inflammatory responses and pathological changes in lung tissue exposed to paraquat.

Pubmed Data : Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2015 Sep ;33(9):689-92. PMID: 26832707

Article Published Date : Aug 31, 2015

Authors : Hongjun Li, Baonan Liu, Peng Li, Lingji Feng, Haihong Ma, Shimeng Xuan, Yongzhi Cao

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Herbicide Toxicity : CK(68) : AC(23)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin supplementation (Meriva ®) modulates inflammation, lipid peroxidation and gut microbiota composition in chronic kidney disease.

Pubmed Data : Nutrients. 2022 Jan 5 ;14(1). Epub 2022 Jan 5. PMID: 35011106

Article Published Date : Jan 04, 2022

Authors : Francesca Pivari, Alessandra Mingione, Giada Piazzini, Camilla Ceccarani, Emerenziana Ottaviano, Caterina Brasacchio, Michele Dei Cas, Margherita Vischi, Mario Gennaro Cozzolino, Paolo Fogagnolo, Antonella Riva, Giovanna Petrangolini, Luigi Barrea, Laura Di Renzo, Elisa Borghi, Paola Signorelli, Rita Paroni, Laura Soldati

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Chronic Kidney Disease (CKD) : CK(1186) : AC(211), Inflammation : CK(16108) : AC(5498), Lipid Peroxidation : CK(2057) : AC(806)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Gastrointestinal Agents : CK(7657) : AC(2274)

curcumin supplementation can improve serum levels of inflammatory cytokines in subjects with NAFLD.

Pubmed Data : Complement Ther Med. 2020 Mar ;49:102322. Epub 2020 Jan 21. PMID: 32147075

Article Published Date : Feb 29, 2020

Authors : Maryam Saberi-Karimian, Mahtab Keshvari, Majid Ghayour-Mobarhan, Leila Salehizadeh, Sepideh Rahmani, Behzad Behnam, Tannaz Jamialahmadi, Sedigheh Asgary, Amirhossein Sahebkar

Study Type : Human Study

Additional Links

Substances : Curcuminoids : CK(7851) : AC(3498)

Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin supplementation improved HFD-induced dyslipidemia, oxidative stress, inflammation and insulin resistance.

Pubmed Data : J Complement Integr Med. 2016 Feb 4. Epub 2016 Feb 4. PMID: 26845728

Article Published Date : Feb 03, 2016

Authors : Nachimuthu Maithilikarpagaselvi, Magadi Gopalakrishna Sridhar, Rathinam Palamalai Swaminathan, Ramalingam Sripradha

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Dyslipidemias : CK(1626) : AC(329), High Fat Diet : CK(2040) : AC(984), Inflammation : CK(16108) : AC(5498), Insulin Resistance : CK(4864) : AC(1098), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Malondialdehyde Down-regulation : CK(3028) : AC(992), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin supplementation improves oxidative stress and inflammation biomarkers in patients undergoing hemodialysis.

Pubmed Data : Int Urol Nephrol. 2022 Mar 26. Epub 2022 Mar 26. PMID: 35347555

Article Published Date : Mar 25, 2022

Authors : Livia Alvarenga, Ludmila F M F Cardozo, Beatriz O Da Cruz, Bruna R Paiva, Denis Fouque, Denise Mafra

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Hemodialysis : CK(1256) : AC(130)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin supplementation mitigates NASH development and progression in female Wistar rats.

Pubmed Data : Physiol Rep. 2018 Jul ;6(14):e13789. PMID: 30009570

Article Published Date : Jun 30, 2018

Authors : Rory P Cunningham, Mary P Moore, Angelique N Moore, James C Healy, Michael D Roberts, R Scott Rector, Jeffrey S Martin

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin supplementation significantly decreases serum concentrations of pro-inflammatory cytokines in subjects with MetS.

Pubmed Data : Biomed Pharmacother. 2016 Jun 6 ;82:578-582. Epub 2016 Jun 6. PMID: 27470399

Article Published Date : Jun 05, 2016

Authors : Yunes Panahi, Mahboobeh Sadat Hosseini, Nahid Khalili, Effat Naimi, Luis E Simental-Mendía, Muhammed Majeed, Amirhossein Sahebkar

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Metabolic Diseases : CK(1273) : AC(272), Metabolic Syndrome X : CK(3095) : AC(546)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin suppresses colorectal tumorigenesis via the Wnt/β-catenin signaling pathway by downregulating Axin2.

Pubmed Data : Oncol Lett. 2021 Mar ;21(3):186. Epub 2021 Jan 6. PMID: 33574925

Article Published Date : Feb 28, 2021

Authors : Jiaxue Hao, Xufen Dai, Juan Gao, Yuexuan Li, Zhaoling Hou, Zhongman Chang, Yuxin Wang

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Colorectal Cancer : CK(4889) : AC(2276)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Chemopreventive : CK(6580) : AC(2166), Wnt/β-catenin signaling pathway modulation : CK(330) : AC(224)

Curcumin suppresses ERK1/2 and p38 signaling, thus, attenuating inflammatory responses of brain microglia.

Pubmed Data : Neurosci Lett. 2015 May 6 ;594:105-10. Epub 2015 Mar 25. PMID: 25818332

Article Published Date : May 05, 2015

Authors : Xiaolei Shi, Zhenyang Zheng, Jie Li, Zijian Xiao, Weiwei Qi, Aiwu Zhang, Qi Wu, Yannan Fang

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Additional Keywords : Dose Response : CK(1770) : AC(700)

Curcumin suppresses gastric NF-kappaB activation and macromolecular leakage in Helicobacter pylori-infected rats.

Pubmed Data : World J Gastroenterol. 2010 Aug 28;16(32):4039-46. PMID: 20731017

Article Published Date : Aug 28, 2010

Authors : Kawiya Sintara, Duangporn Thong-Ngam, Suthiluk Patumraj, Naruemon Klaikeaw, Tanittha Chatsuwan

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Helicobacter Pylori Infection : CK(1213) : AC(275)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression associated with inflammation.

Pubmed Data : J Pharmacol Sci. 2004 Mar;94(3):325-8. PMID: 15037818

Article Published Date : Mar 01, 2004

Authors : Gu Kang, Pil-Jae Kong, Young-Jin Yuh, So-Young Lim, Sung-Vin Yim, Wanjoo Chun, Sung-Soo Kim

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain: Microglial Activation : CK(205) : AC(118), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin suppresses the inflammatory response of brain microglial cells.

Pubmed Data : J Immunol. 2003 Dec 1;171(11):6072-9. PMID: 14634121

Article Published Date : Dec 01, 2003

Authors : Hee Young Kim, Eun Jung Park, Eun-Hye Joe, Ilo Jou

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain: Microglial Activation : CK(205) : AC(118), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327)

Curcumin suppresses titanium particle-induced inflammation by regulating macrophage polarization.

Pubmed Data : Front Immunol. 2017 ;8:55. Epub 2017 Jan 31. PMID: 28197150

Article Published Date : Dec 31, 2016

Authors : Bin Li, Yan Hu, Yaochao Zhao, Mengqi Cheng, Hui Qin, Tao Cheng, Qiaojie Wang, Xiaochun Peng, Xianlong Zhang

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Titanium Toxicity : CK(31) : AC(18)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-10 upregulation : CK(1296) : AC(436), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin suppresses type II collagen-induced arthritis in mice.

Pubmed Data : J Pharmacol Sci. 2009 Sep;111(1):13-21. PMID: 19763044

Article Published Date : Sep 01, 2009

Authors : Se Hwan Mun, Hyuk Soon Kim, Jie Wan Kim, Na Young Ko, Do Kyun Kim, Beob Yi Lee, Bokyung Kim, Hyung Sik Won, Hwa-Sup Shin, Jeung-Whan Han, Hoi Young Lee, Young Mi Kim, Wahn Soo Choi

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Arthritis : CK(5826) : AC(1505), Rheumatoid Arthritis : CK(2322) : AC(562)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Matrix metalloproteinase-1 (MMP-1) inhibitor : CK(155) : AC(92), Matrix metalloproteinase-3 (MMP-3) inhibitor : CK(238) : AC(107)

Curcumin suppression of cytokine release and cytokine storm. A potential therapy for patients with Ebola and other severe viral infections.

Pubmed Data : In Vivo. 2015 Jan-Feb;29(1):1-4. PMID: 25600522

Article Published Date : Dec 31, 2014

Authors : Peter P Sordillo, Lawrence Helson

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Ebola : CK(17) : AC(17)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Cytokine Modulation : CK(58) : AC(26), Cytokine Storm : CK(196) : AC(77)

Curcumin targeting NF- κ B/ubiquitin-proteasome-system axis ameliorates muscle atrophy in triple-negative breast cancer cachexia.

Pubmed Data : Mediators Inflamm. 2022 ;2022:2567150. Epub 2022 Jan 29. PMID: 35132306

Article Published Date : Dec 31, 2021

Authors : Jin Zhang, Jin Zheng, Haitao Chen, Xinrong Li, Chenxiao Ye, Fan Zhang, Zewei Zhang, Qinghua Yao, Yong Guo

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Breast Cancer : CK(8297) : AC(3043), Cachexia: Cancer : CK(164) : AC(60)

Pharmacological Actions : Anti-Cachexic Agents : CK(129) : AC(50), Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin targets numerous therapeutically important cancer signalling pathways.

Pubmed Data : Tumour Biol. 2016 Jul 28. Epub 2016 Jul 28. PMID: 27468716

Article Published Date : Jul 27, 2016

Authors : Pandima Devi Kasi, Rajavel Tamilselvam, Krystyna Skalicka-Woźniak, Seyed Fazel Nabavi, Maria Daglia, Anupam Bishayee, Hamidreza Pazoki-Toroudi, Seyed Mohammad Nabavi

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cancers: All : CK(36404) : AC(14363)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379), Tumor Suppressor Protein p53 Upregulation : CK(755) : AC(554), Wnt/β-catenin pathway down-regulation : CK(96) : AC(58)

Additional Keywords : Tumor Microenvironment : CK(170) : AC(121)

Curcumin treatment ameliorates colonic damage in chemically-induced colitic rats.

Pubmed Data : World J Gastroenterol. 2007 Feb 21;13(7):1103-7. PMID: 17373747

Article Published Date : Feb 21, 2007

Authors : M V Venkataranganna, Md Rafiq, S Gopumadhavan, Ghouse Peer, U V Babu, S K Mitra

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Oxidative Stress : CK(14758) : AC(5716), Ulcerative Colitis : CK(1411) : AC(447)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin treatment attenuates lipopolysaccharide induced liver injury.

Pubmed Data : Biomed Pharmacother. 2016 Jul 6 ;83:302-313. Epub 2016 Jul 6. PMID: 27393927

Article Published Date : Jul 05, 2016

Authors : Wenhui Zhong, Kejian Qian, Jibin Xiong, Ke Ma, Aizhong Wang, Yan Zou

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875), Sepsis : CK(1436) : AC(491)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin treatment attenuates liver lesions induced by intestinal ischemia/reperfusion.

Pubmed Data : Oxid Med Cell Longev. 2014 ;2014:191624. Epub 2014 Aug 20. PMID: 25215173

Article Published Date : Dec 31, 2013

Authors : Zhe Fan, Huirong Jing, Jihong Yao, Yang Li, Xiaowei Hu, Huizhu Shao, Gang Shen, Jiyong Pan, Fuwen Luo, Xiaofeng Tian

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Intestinal Ischemia : CK(64) : AC(32), Liver Damage : CK(4109) : AC(1872)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831), Interleukin-6 Downregulation : CK(9337) : AC(3613), NF-kappaB Inhibitor : CK(5952) : AC(3464), Superoxide Dismutase Up-regulation : CK(2383) : AC(928)

Curcumin treatment significantly improved the neurological status evaluated during 2 weeks after brain injury.

Pubmed Data : Pharmacol Biochem Behav. 2013 Sep ;110:238-44. Epub 2013 Aug 7. PMID: 23932920

Article Published Date : Aug 31, 2013

Authors : Fariborz Samini, Saeed Samarghandian, Abasalt Borji, Gholamreza Mohammadi, Mahdi bakaian

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain Inflammation : CK(1784) : AC(928), Brain Injury: Traumatic : CK(383) : AC(131), Lipid Peroxidation : CK(2057) : AC(806), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Malondialdehyde Down-regulation : CK(3028) : AC(992), Neuroprotective Agents : CK(20061) : AC(7949)

Additional Keywords : Significant Treatment Outcome : CK(4297) : AC(505)

Curcumin treats endometriosis in mice by the HIF signaling pathway.

Pubmed Data : Am J Transl Res. 2022 ;14(4):2184-2198. Epub 2022 Apr 15. PMID: 35559378

Article Published Date : Dec 31, 2021

Authors : Jie Ding, Shanshan Mei, Wen Cheng, Zhexin Ni, Chaoqin Yu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Endometriosis : CK(579) : AC(159)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Vascular Endothelial Growth Factor A Inhibitor : CK(231) : AC(127)

Curcumin was demonstrated to be effective as an adjuvant therapy for the treatment of psoriasis vulgaris and to significantly reduce serum levels of IL-22.

Pubmed Data : Biomed Res Int. 2015 ;2015:283634. Epub 2015 May 18. PMID: 26090395

Article Published Date : Dec 31, 2014

Authors : Emiliano Antiga, Veronica Bonciolini, Walter Volpi, Elena Del Bianco, Marzia Caproni

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Psoriasis : CK(922) : AC(255)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360), Interleukin-22 Downregulation : CK(40) : AC(20)

Curcumin was effective in restoring the histopathological changes induced by acetic acid administration.

Pubmed Data : J Environ Pathol Toxicol Oncol. 2015;34(4):309-320. PMID: 26756424

Article Published Date : Dec 31, 2014

Authors : Boobalan Gopu, Rasakatla Dileep, Matukumalli Usha Rani, C S V Satish Kumar, Matham Vijay Kumar, Alla Gopala Reddy

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Inflammatory Bowel Diseases : CK(3196) : AC(926)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(3243) : AC(656)

Curcumin was found to have anti-hyperalgesic activity by decreasing oxidative stress and down regulation of inflammatory cytokines.

Pubmed Data : Neurochem Res. 2015 Mar ;40(3):463-72. Epub 2014 Dec 6. PMID: 25479948

Article Published Date : Feb 28, 2015

Authors : Ajeet Kumar Singh, Manjula Vinayak

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Hyperalgesia : CK(339) : AC(152), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin's anti-inflammatory properties are related to its ability to inhibit the neutrophil response.

Pubmed Data : Agents Actions. 1989 Nov;28(3-4):298-303. PMID: 2556903

Article Published Date : Nov 01, 1989

Authors : R Srivastava

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin's beneficial effects on neuroblastoma: Mechanisms, challenges, and potential solutions.

Pubmed Data : Biomolecules. 2020 Oct 22 ;10(11). Epub 2020 Oct 22. PMID: 33105719

Article Published Date : Oct 21, 2020

Authors : Kevin Zhai, Aranka Brockmüller, Peter Kubatka, Mehdi Shakibaei, Dietrich Büsselberg

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Neuroblastoma : CK(223) : AC(142)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Chemotherapeutic : CK(4390) : AC(1635), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin's mechanism of action against ischemic stroke.

Pubmed Data : PLoS One. 2023 ;18(1):e0280112. Epub 2023 Jan 4. PMID: 36598916

Article Published Date : Dec 31, 2022

Authors : Yangyang Wang, Guoxiu Zu, Ying Yu, Jiqin Tang, Tao Han, Chengdong Zhang

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Stroke: Ischemic : CK(1030) : AC(284)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin, autoimmune and inflammatory diseases: going beyond conventional therapy - a systematic review

Pubmed Data : Crit Rev Food Sci Nutr. 2020 Dec 1:1-19. Epub 2020 Dec 1. PMID: 33938775

Article Published Date : Nov 30, 2020

Authors : Ledyane Taynara Marton, Sandra Maria Barbalho, Kátia Portero Sloan, Lance Alan Sloan, Ricardo de Alvares Goulart, Adriano Cressoni Araújo, Marcelo Dib Bechara

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)

Diseases : Autoimmune Diseases : CK(12040) : AC(2692), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin, berberine chloride and epigallocatechin gallate could be potential alternatives for prednisolone in inflammation.

Pubmed Data : PLoS One. 2016 ;11(5):e0155325. Epub 2016 May 10. PMID: 27163931

Article Published Date : Dec 31, 2015

Authors : Iris E Allijn, Stefan F C Vaessen, Linda C Quarles van Ufford, Kees J Beukelman, Menno P J de Winther, Gert Storm, Raymond M Schiffelers

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(2483) : AC(1079), Curcumin : CK(7239) : AC(3319), EGCG (Epigallocatechin gallate) : CK(1587) : AC(820)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210), Atherosclerosis : CK(2063) : AC(778), Coronavirus Infection : CK(3250) : AC(986), Huntington Disease : CK(222) : AC(103), Inflammatory Bowel Diseases : CK(3196) : AC(926), Liver Fibrosis : CK(882) : AC(399), Multiple Sclerosis : CK(2432) : AC(557), Parkinson's Disease : CK(3012) : AC(1116), Psoriasis : CK(922) : AC(255), Rheumatoid Arthritis : CK(2322) : AC(562)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Additional Keywords : Natural Substances Versus Drugs : CK(2806) : AC(560)

Problem Substances : Prednisolone : CK(6) : AC(3)

Curcumin, capsaicin and piperine have anti-inflammatory effects on H. pylori-induced gastritis in gerbils and may have potential chemoprevention of H. pylori-associated gastric carcinogenesis.

Pubmed Data : Helicobacter. 2015 Jul 3. Epub 2015 Jul 3. PMID: 26140520

Article Published Date : Jul 02, 2015

Authors : Takeshi Toyoda, Liang Shi, Shinji Takasu, Young-Man Cho, Yuka Kiriyama, Akiyoshi Nishikawa, Kumiko Ogawa, Masae Tatematsu, Tetsuya Tsukamoto

Study Type : Animal Study

Additional Links

Substances : Capsaicin : CK(338) : AC(129), Curcumin : CK(7239) : AC(3319), Piperine : CK(600) : AC(258)

Diseases : Gastritis : CK(126) : AC(38), Helicobacter Pylori Infection : CK(1213) : AC(275)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anticarcinogenic Agents : CK(2152) : AC(1018), Chemopreventive : CK(6580) : AC(2166)

Curcumin, EGCG and resveratrol inhibit inflammation.

Pubmed Data : Mutat Res. 2001 Sep 1;480-481:243-68. PMID: 11506818

Article Published Date : Sep 01, 2001

Authors : Y J Surh, K S Chun, H H Cha, S S Han, Y S Keum, K K Park, S S Lee

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), EGCG (Epigallocatechin gallate) : CK(1587) : AC(820), Resveratrol : CK(3228) : AC(1513)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anticarcinogenic Agents : CK(2152) : AC(1018), Cyclooxygenase 1 Inhibitor : CK(85) : AC(62), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin, resveratrol and flavonoids act as anti-inflammatory, cyto- and DNA-protective dietary compounds.

Pubmed Data : Toxicology. 2009 Nov 10. Epub 2009 Nov 10. PMID: 19903510

Article Published Date : Nov 10, 2009

Authors : Kavita Bisht, Karl-Heinz Wagner, Andrew C Bulmer

Study Type : Commentary

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Flavonoids : CK(4698) : AC(2176), Resveratrol : CK(3228) : AC(1513)

Diseases : DNA damage : CK(2301) : AC(842)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin, silybin phytosome® and α-R-lipoic acid may confer therapeutic efficacy against chronic hepatitis.

Pubmed Data : Basic Clin Pharmacol Toxicol. 2015 Oct 12. Epub 2015 Oct 12. PMID: 26457982

Article Published Date : Oct 11, 2015

Authors : Shimaa O Ali, Hebatallah A Darwish, Nabila A Ismail

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid : CK(1501) : AC(366), Curcumin : CK(7239) : AC(3319)

Diseases : Chronic Hepatitis : CK(12) : AC(2)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Curcumin, when used as a complementary treatment to albendazole, could help to alleviate eosinophilic meningitis through suppression of eosinophil count in the cerebrospinal fluid.

Pubmed Data : Parasitology. 2012 Mar ;139(3):358-65. Epub 2011 Nov 7. PMID: 22053741

Article Published Date : Feb 29, 2012

Authors : Ling-Yuh Shyu, Han-Hsin Chang, Jeng-Dong Hsu, David Pei-Cheng Lin, Ying-Hock Teng, Hsiu-Hsiung Lee

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Angiostrongylus Cantonensis Infection : CK(4) : AC(2), Eosinophilic Meningitis : CK(4) : AC(2)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(944) : AC(588)

Curcumin-added whey protein positively modulates skeletal muscle inflammation and oxidative damage after exhaustive exercise.

Pubmed Data : Nutrients. 2022 Nov 19 ;14(22). Epub 2022 Nov 19. PMID: 36432591

Article Published Date : Nov 18, 2022

Authors : Kelly Aparecida Dias, Aline Rosignoli da Conceição, Stephanie Michelin Santana Pereira, Lívya Alves Oliveira, João Vitor da Silva Rodrigues, Roberto Sousa Dias, Sérgio Oliveira de Paula, Antônio José Natali, Sérgio Luis Pinto da Matta, Reggiani Vilela Gonçalves, Elad Tako, Hercia Stampini Duarte Martino, Ceres Mattos Della Lucia

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Whey : CK(733) : AC(150)

Diseases : Inflammation : CK(16108) : AC(5498), Muscle Soreness: Exercise-Induced : CK(360) : AC(39), Oxidative Stress : CK(14758) : AC(5716)

Therapeutic Actions : Exercise : CK(6919) : AC(1026)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-10 upregulation : CK(1296) : AC(436), Interleukin-6 Downregulation : CK(9337) : AC(3613)

Curcumin-based nanomedicines in the treatment of inflammatory and immunomodulated diseases.

Pubmed Data : Pharmaceutics. 2023 Jan 10 ;15(1). Epub 2023 Jan 10. PMID: 36678859

Article Published Date : Jan 09, 2023

Authors : Lucas Fornari Laurindo, Gabriel Magno de Carvalho, Bárbara de Oliveira Zanuso, Maria Eduardo Figueira, Rosa Direito, Ricardo de Alvares Goulart, Daiene Santos Buglio, Sandra Maria Barbalho

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360)

Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities.

Pubmed Data : Mol Nutr Food Res. 2013 Sep ;57(9):1529-42. Epub 2013 Jul 12. PMID: 23847105

Article Published Date : Aug 31, 2013

Authors : Bharat B Aggarwal, Wei Yuan, Shiyou Li, Subash C Gupta

Study Type : Review

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Cancers: All : CK(36404) : AC(14363), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antineoplastic Agents : CK(2235) : AC(1468), Antioxidants : CK(34551) : AC(14499), Chemopreventive : CK(6580) : AC(2166)

Curcumin-galactomannoside complex offered significant hepatoprotective effects to attenuate alcohol induced alterations to hepatic function markers.

Pubmed Data : Biomed Res Int. 2018 ;2018:9159281. Epub 2018 Sep 23. PMID: 30345312

Article Published Date : Dec 31, 2017

Authors : Naveen T Krishnareddy, Jestin V Thomas, Saritha S Nair, Johannah N Mulakal, Balu P Maliakel, I M Krishnakumar

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Alcohol Toxicity : CK(1235) : AC(480), Alcoholic Liver Disease : CK(611) : AC(283)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin-loaded lipid nanoemulsions have therapeutic applications in different inflammatory pathologies localized in the liver or the lungs.

Pubmed Data : J Pharm Pharmacol. 2016 Jan 8. Epub 2016 Jan 8. PMID: 26748549

Article Published Date : Jan 07, 2016

Authors : Viorel Simion, Daniela Stan, Cristina Ana Constantinescu, Mariana Deleanu, Emanuel Dragan, Monica Madalina Tucureanu, Ana-Maria Gan, Elena Butoi, Alina Constantin, Ileana Manduteanu, Maya Simionescu, Manuela Calin

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Nanoencapsulated Curcumin : CK(5) : AC(3)

Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies.

Pubmed Data : Phytother Res. 2023 Jan 31. Epub 2023 Jan 31. PMID: 36720711

Article Published Date : Jan 30, 2023

Authors : Hajar Heidari, Mohammad Bagherniya, Muhammed Majeed, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Piperine : CK(600) : AC(258)

Diseases : Obesity : CK(11004) : AC(2672)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hypoglycemic Agents : CK(9221) : AC(2076), Hypolipidemic : CK(9173) : AC(2038)

Curcumin: A golden approach to healthy aging: A systematic review of the evidence.

Pubmed Data : Nutrients. 2024 Aug 15 ;16(16). Epub 2024 Aug 15. PMID: 39203857

Article Published Date : Aug 14, 2024

Authors : Yandra Cervelim Nunes, Nathalia M Mendes, Enzo Pereira de Lima, Amanda Chabrour Chehadi, Caroline Barbalho Lamas, Jesselina F S Haber, Manoela Dos Santos Bueno, Adriano Cressoni Araújo, Vitor C Strozze Catharin, Claudia Rucco P Detregiachi, Lucas Fornari Laurindo, Masaru Tanaka, Sandra Maria Barbalho, Maria JoséSanches Marin

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Aging : CK(6221) : AC(1510), Cardiovascular Diseases : CK(17333) : AC(2878), Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716), Sarcopenia : CK(368) : AC(79)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin: a modulator of inflammatory signaling pathways in the immune system.

Pubmed Data : Inflammopharmacology. 2019 Oct ;27(5):885-900. Epub 2019 May 28. PMID: 31140036

Article Published Date : Sep 30, 2019

Authors : Kolsoum Rezaie Kahkhaie, Ali Mirhosseini, Ali Aliabadi, Asadollah Mohammadi, Mohammad Javad Mousavi, Saeed Mohammadian Haftcheshmeh, Thozhukat Sathyapalan, Amirhossein Sahebkar

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin: A potential detoxifier against chemical and natural toxicants.

Pubmed Data : Phytother Res. 2025 Mar ;39(3):1494-1530. Epub 2025 Jan 24. PMID: 39853860

Article Published Date : Feb 28, 2025

Authors : Harsh Kumar, Rajni Dhalaria, Neetika Kimta, Shivani Guleria, Navneet Kumar Upadhyay, Eugenie Nepovimova, Daljeet Singh Dhanjal, Nidhi Sethi, Sivakumar Manickam

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Chemical Exposure : CK(112) : AC(40), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Detoxifier : CK(856) : AC(254)

Curcumin: A therapeutic strategy for targeting the Helicobacter pylori-related diseases.

Pubmed Data : Microb Pathog. 2022 May ;166:105552. Epub 2022 Apr 22. PMID: 35469998

Article Published Date : Apr 30, 2022

Authors : Asadollah Mohammadi, Hashem Khanbabaei, Farid Zandi, Abbas Ahmadi, Saeed Mohammadian Haftcheshmeh, Thomas P Johnston, Amirhossein Sahebkar

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Gastric Cancer : CK(1619) : AC(725), Helicobacter Pylori Infection : CK(1213) : AC(275)

Pharmacological Actions : Anti-Bacterial Agents : CK(4228) : AC(1989), Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumin: An insight to molecular pathways involved in anticancer activity.

Pubmed Data : Mini Rev Med Chem. 2021 Jan 22. Epub 2021 Jan 22. PMID: 33480345

Article Published Date : Jan 21, 2021

Authors : Priyanka Joshi, Sushil Joshi, Deepak Semwal, Akansha Bisht, Sarvesh Paliwal, Jaya Dwivedi, Swapnil Sharma

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cancers: All : CK(36404) : AC(14363)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Chemotherapeutic : CK(4390) : AC(1635), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Nrf2 activation : CK(3156) : AC(1794), Postaglandin PGE2 downregulation : CK(386) : AC(199), STAT3 Inhibitor : CK(322) : AC(216)

Curcumin@Fe/tannic acid complex nanoparticles for inflammatory bowel disease treatment.

Pubmed Data : ACS Omega. 2024 Mar 26 ;9(12):14316-14322. Epub 2024 Mar 14. PMID: 38559927

Article Published Date : Mar 25, 2024

Authors : Jiman Jin, Xiuzhi Ye, Zhenfeng Huang, Shicui Jiang, Dini Lin

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Tannic Acid : CK(120) : AC(71)

Diseases : Inflammatory Bowel Diseases : CK(3196) : AC(926)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Gastrointestinal Agents : CK(7657) : AC(2274)

Curcuminoid supplementation for twelve weeks attenuates lipid peroxidation and might reduce uremic toxin in patients with chronic kidney disease undergoing peritoneal dialysis.

Pubmed Data : Clin Nutr ESPEN. 2024 Feb ;59:96-106. Epub 2023 Nov 28. PMID: 38220413

Article Published Date : Jan 31, 2024

Authors : Drielly C M V Reis, Livia Alvarenga, Ludmila F M F Cardozo, Beatriz G Baptista, Susane Fanton, Bruna R Paiva, Marcelo Ribeiro-Alves, Rodrigo S Fortunato, Andressa L Vasconcelos, Lia S Nakao, Carmen Lucia Sanz, Andresa A Berretta, Maurilo Leite, Denise Mafra

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Chronic Kidney Disease (CKD) : CK(1186) : AC(211), Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcuminoids from Curcuma Longa: New adjuvants for the treatment of crohn's disease and ulcerative colitis?

Pubmed Data : Crit Rev Food Sci Nutr. 2019 ;59(13):2136-2143. Epub 2018 Apr 12. PMID: 29565637

Article Published Date : Dec 31, 2018

Authors : Fernando Cunha Neto, Ledyane Taynara Marton, Sâmylla Vaz de Marqui, Tainah Aparecida Lima, Sandra Maria Barbalho

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Crohn's Disease : CK(242) : AC(55), Oxidative Stress : CK(14758) : AC(5716), Ulcerative Colitis : CK(1411) : AC(447)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Curcuminoids represent an effective and safe alternative treatment for OA.

Pubmed Data : Phytother Res. 2014 Nov ;28(11):1625-31. Epub 2014 May 22. PMID: 24853120

Article Published Date : Oct 31, 2014

Authors : Yunes Panahi, Ali-Reza Rahimnia, Mojtaba Sharafi, Gholamhossein Alishiri, Amin Saburi, Amirhossein Sahebkar

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Osteoarthritis: Knee : CK(2345) : AC(276)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Phytotherapy : CK(4003) : AC(1031)

Curcuminoids supplementation ameliorates iron overload, oxidative stress, hypercoagulability, and inflammation.

Pubmed Data : Ann Hematol. 2021 Jan 3. Epub 2021 Jan 3. PMID: 33388858

Article Published Date : Jan 02, 2021

Authors : Suneerat Hatairaktham, Patarabutr Masaratana, Chattree Hantaweepant, Chatchawan Srisawat, Vorapan Sirivatanauksorn, Noppadol Siritanaratkul, Narumol Panichkul, Ruchaneekorn W Kalpravidh

Study Type : Human Study

Additional Links

Substances : Curcuminoids : CK(7851) : AC(3498)

Diseases : Inflammation : CK(16108) : AC(5498), Iron Overload : CK(220) : AC(79), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcuminoids: Implication for inflammation and oxidative stress in cardiovascular diseases.

Pubmed Data : Phytother Res. 2019 Mar 4. Epub 2019 Mar 4. PMID: 30834628

Article Published Date : Mar 03, 2019

Authors : Cheng Li, Xiao Miao, Fengsheng Li, Binay Kumar Adhikari, Yucheng Liu, Jian Sun, Rong Zhang, Lu Cai, Quan Liu, Yonggang Wang

Study Type : Review

Additional Links

Substances : Bisdemethoxycurcumin : CK(123) : AC(71), Curcumin : CK(7239) : AC(3319), Demethoxycurcumin : CK(80) : AC(53)

Diseases : Cardiovascular Diseases : CK(17333) : AC(2878)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963)

Curcumol alleviates the inflammation of nucleus pulposus cells via the PI3K/Akt/NF-κB signaling pathway and delays intervertebral disk degeneration.

Pubmed Data : World Neurosurg. 2021 Aug 24. Epub 2021 Aug 24. PMID: 34450323

Article Published Date : Aug 23, 2021

Authors : Shenghua He, Yuanfei Fu, Bona Yan, Huangsheng Tan, Haokang Li, Jin Li, Dan Huang, Zhuohan Huang, Juyi Lai, Hualong Feng, Zhitao Sun, Zhiming Lan

Study Type : In Vitro Study

Additional Links

Substances : Curcumol : CK(109) : AC(78)

Diseases : Degenerative Disk Disease : CK(132) : AC(72)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumol ameliorates lung inflammation and airway remodeling.

Pubmed Data : Drug Des Devel Ther. 2021 ;15:2641-2651. Epub 2021 Jun 21. PMID: 34188444

Article Published Date : Dec 31, 2020

Authors : Shanshan Jia, Pin Guo, Junhua Lu, Xujun Huang, Laming Deng, Yan Jin, Lanyan Zhao, Xiaofang Fan

Study Type : Animal Study

Additional Links

Substances : Curcumol : CK(109) : AC(78)

Diseases : Asthma : CK(3242) : AC(707)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Curcumol and curcumin showed an anti-inflammatory effect by inhibiting the NF-κB signaling pathway.

Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:3035125. Epub 2019 Mar 17. PMID: 31007701

Article Published Date : Dec 31, 2018

Authors : Ning Li, Tian-Hao Liu, Jing-Ze Yu, Chen-Xi Li, Yang Liu, Yue-Ying Wu, Zhong-Shan Yang, Jia-Li Yuan

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Curcumol : CK(109) : AC(78)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumol attenuates endometriosis by inhibiting the JAK2/STAT3 signaling pathway.

Pubmed Data : Med Sci Monit. 2022 Mar 13 ;28:e934914. Epub 2022 Mar 13. PMID: 35279667

Article Published Date : Mar 12, 2022

Authors : Yan Wang, Xiao-Bo Nie, Su-Jun Liu, Jiao Liu, Wen-Hui Bian

Study Type : In Vitro Study

Additional Links

Substances : Curcumol : CK(109) : AC(78)

Diseases : Endometriosis : CK(579) : AC(159)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumol may alleviate psoriasis-like inflammation by inhibiting keratinocyte proliferation and inflammatory gene expression.

Pubmed Data : Aging (Albany NY). 2021 07 27 ;13(14):18392-18403. Epub 2021 Jul 27. PMID: 34314383

Article Published Date : Jan 26, 2021

Authors : Mingfen Lv, Junyi Shao, Fan Jiang, Jingjing Liu

Study Type : In Vitro Study

Additional Links

Substances : Curcumol : CK(109) : AC(78)

Diseases : Psoriasis : CK(922) : AC(255)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antiproliferative : CK(10001) : AC(7491), STAT3 Inhibitor : CK(322) : AC(216)

Curcumol may be one of the mechanisms of antihepatic fibrosis by inhibiting the activity of the NF-κB signaling.

Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:8590638. Epub 2020 May 28. PMID: 32595742

Article Published Date : Dec 31, 2019

Authors : Yang Zheng, Jiahui Wang, Jiaru Wang, Haiyuan Xie, Tiejian Zhao

Study Type : In Vitro Study

Additional Links

Substances : Curcumol : CK(109) : AC(78)

Diseases : Liver Fibrosis : CK(882) : AC(399)

Pharmacological Actions : Anti-Fibrotic : CK(2209) : AC(1052), Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumolide reduces diabetic retinal vascular leukostasis.

Pubmed Data : Bioorg Med Chem Lett. 2017 Apr 15 ;27(8):1835-1839. Epub 2017 Feb 22. PMID: 28274631

Article Published Date : Apr 14, 2017

Authors : Yuan Cai, Wencan Li, Hongfeng Tu, Nanmei Chen, Zhipeng Zhong, Pengcheng Yan, Jianyong Dong

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Diabetic Retinopathy : CK(483) : AC(211)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Current data suggest that curcumin undergoes degradation due to roasting and its degradation product exhibit significant biological activity in cultured cells.

Pubmed Data : Food Funct. 2015 Mar 11 ;6(3):887-93. PMID: 25619943

Article Published Date : Mar 10, 2015

Authors : Tuba Esatbeyoglu, Katrin Ulbrich, Clemens Rehberg, Sascha Rohn, Gerald Rimbach

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Curcumin: Degradiation byproducts : CK(13) : AC(8)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613)

Additional Keywords : Gene Expression : CK(288) : AC(107)

Curumin reduces inflammation associated with Angiostrongylus cantonensis-induced eosinophilic meningitis.

Pubmed Data : J Helminthol. 2007 Mar;81(1):1-5. PMID: 17381860

Article Published Date : Mar 01, 2007

Authors : P C Shih, H H Lee, S C Lai, K M Chen, S T Jiang, Y F Chen, S J Shiow

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Angiostrongylus Cantonensis Infection : CK(4) : AC(2), Eosinophilic Meningitis : CK(4) : AC(2)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Demethoxycurcumin abrogates rotenone-induced dopamine depletion and motor deficits.

Pubmed Data : Pharmacogn Mag. 2018 Jan-Mar;14(53):9-16. Epub 2018 Feb 20. PMID: 29576695

Article Published Date : Dec 31, 2017

Authors : Muthu Ramkumar, Srinivasagam Rajasankar, Veerapan Venkatesh Gobi, Udaiyappan Janakiraman, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Musthafa Mohamed Essa, Ranganathan Chidambaram, Saravana Babu Chidambaram, Giles J Guillemin

Study Type : Animal Study

Additional Links

Substances : Demethoxycurcumin : CK(80) : AC(53)

Diseases : Parkinson's Disease : CK(3012) : AC(1116)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Demethoxycurcumin increases PPARγ expression, resulting in autophagy and NF-κB inhibition.

Pubmed Data : Curr Mol Pharmacol. 2021 Mar 1. Epub 2021 Mar 1. PMID: 33645492

Article Published Date : Feb 28, 2021

Authors : Jing Tang, Xiaoxue Tan, Xiangmi Huang, Jie Zhang, Liang Chen, Aiyuan Li, Deming Wang

Study Type : In Vitro Study

Additional Links

Substances : Demethoxycurcumin : CK(80) : AC(53)

Diseases : Inflammation : CK(16108) : AC(5498), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Demethoxycurcumin induces apoptosis via inhibition of NF-κB pathway in FaDu human head and neck squamous cell carcinoma.

Pubmed Data : Transl Cancer Res. 2022 May ;11(5):1064-1075. PMID: 35706794

Article Published Date : Apr 30, 2022

Authors : Gyeong-Je Lee, HyangI Lim, Jeong-Yeon Seo, Kyeong-Rok Kang, Do Kyung Kim, Jae-Seek You, Ji-Su Oh, Yo-Seob Seo, Jae-Sung Kim

Study Type : In Vitro Study

Additional Links

Substances : Demethoxycurcumin : CK(80) : AC(53)

Diseases : Head and Neck Cancer : CK(797) : AC(189)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Apoptotic : CK(9585) : AC(7379), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses in microglia cells.

Pubmed Data : Int Immunopharmacol. 2010 Mar;10(3):331-8. Epub 2009 Dec 16. PMID: 20018257

Article Published Date : Mar 01, 2010

Authors : Lijia Zhang, Chunfu Wu, Siqi Zhao, Dan Yuan, Guoning Lian, Xiaoxiao Wang, Lihui Wang, Jingyu Yang

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain: Microglial Activation : CK(205) : AC(118), Inflammation : CK(16108) : AC(5498), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), NF-kappaB Inhibitor : CK(5952) : AC(3464), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Demethoxycurcumin: A naturally occurring curcumin analogue for treating non-cancerous diseases.

Pubmed Data : J Cell Physiol. 2019 Nov ;234(11):19320-19330. Epub 2019 Apr 4. PMID: 31344992

Article Published Date : Oct 31, 2019

Authors : Mahdi Hatamipour, Mahin Ramezani, Sayyed Abolghasem Sajadi Tabassi, Thomas P Johnston, Amirhossein Sahebkar

Study Type : Review

Additional Links

Substances : Demethoxycurcumin : CK(80) : AC(53)

Diseases : Hypertension : CK(9125) : AC(1361), Inflammation : CK(16108) : AC(5498), Malaria : CK(303) : AC(135)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antifungal Agents : CK(730) : AC(422), Antihypertensive Agents : CK(7081) : AC(1029), Antimalarials : CK(125) : AC(78), Antimicrobial : CK(1577) : AC(790), Neuroprotective Agents : CK(20061) : AC(7949), Vasodilator Agents : CK(892) : AC(233)

Diarylheptanoids of Curcuma comosa inhibited lipopolysaccharide induced nitric oxide production in macrophage RAW 264.7 cells

Pubmed Data : Nat Prod Commun. 2015 Jan ;10(1):89-93. PMID: 25920227

Article Published Date : Dec 31, 2014

Authors : Nilubon Sornkaewa, Yuan Lin, Fei Wang, Guolin Zhang, Ratchanaporn Chokchaisiri, Ailian Zhang, Kanjana Wongkrajang, Parichat Suebsakwong, Pawinee Piyachaturawat, Apichart Suksamrarn

Study Type : In Vitro Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Nitric Oxide Inhibitor : CK(705) : AC(356)

Dietary curcumin prevents colon carcinogenesis.

Pubmed Data : Cancer Res. 1995 Jan 15;55(2):259-66. PMID: 7812955

Article Published Date : Jan 15, 1995

Authors : C V Rao, A Rivenson, B Simi, B S Reddy

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Colon Cancer : CK(1920) : AC(1203)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Dietary omega-3 fatty acids, curcumin and capsaicin lower the release of lysosomal enzymes and eicosanoids in rat peritoneal macrophages associated with inflammation.

Pubmed Data : Mol Cell Biochem. 2000 Jan;203(1-2):153-61. PMID: 10724344

Article Published Date : Jan 01, 2000

Authors : B Joe, B R Lokesh

Study Type : In Vitro Study

Additional Links

Substances : Capsaicin : CK(338) : AC(129), Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Leukotriene B4 downregulation : CK(13) : AC(4), Leukotriene C4 Downregulation : CK(2) : AC(2), Prostaglandin PGE2 downregulation : CK(194) : AC(89)

Dietary phytochemicals as neurotherapeutics for autism spectrum disorder: Plausible mechanism and evidence.

Pubmed Data : Adv Neurobiol. 2020 ;24:615-646. PMID: 32006377

Article Published Date : Dec 31, 2019

Authors : Ranjana Bhandari, Jyoti K Paliwal, Anurag Kuhad

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Naringenin : CK(704) : AC(394), Resveratrol : CK(3228) : AC(1513), Sulforaphane : CK(1344) : AC(630)

Diseases : Autism Spectrum Disorders : CK(3722) : AC(571)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), NF-kappaB Inhibitor : CK(5952) : AC(3464), Nrf2 activation : CK(3156) : AC(1794)

Additional Keywords : Gut-brain Axis : CK(686) : AC(289)

Dietary supplementation of curcumin alleviates NF-κB-dependent skeletal muscle wasting in rats.

Pubmed Data : Endocr Metab Immune Disord Drug Targets. 2016 Jun 13. Epub 2016 Jun 13. PMID: 27297427

Article Published Date : Jun 12, 2016

Authors : Jun Hejun8067 163 Com He, Hongmei Xie, Shan Wu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cachexia : CK(96) : AC(36)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Dietary turmeric led to a decrease in DMBA-induced tumor burden and multiplicity in animals.

Pubmed Data : Toxicol Appl Pharmacol. 2008 Nov 1 ;232(3):428-39. Epub 2008 Jul 19. PMID: 18687351

Article Published Date : Oct 31, 2008

Authors : Rachana Garg, Arvind Ingle, Girish Maru

Study Type : Animal Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Oral Cancer : CK(717) : AC(384), Oral Cancer: Prevention : CK(88) : AC(18)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anticarcinogenic Agents : CK(2152) : AC(1018), Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379), Bcl-2 protein down-regulation : CK(711) : AC(529), NF-kappaB Inhibitor : CK(5952) : AC(3464), Postaglandin PGE2 downregulation : CK(386) : AC(199)

Dual anti-inflammatory effects of curcumin and berberine on acetaminophen-induced liver injury.

Pubmed Data : Biochem Biophys Res Commun. 2024 Nov 19 ;734:150772. Epub 2024 Sep 30. PMID: 39362031

Article Published Date : Nov 18, 2024

Authors : Fengguo Zhai, Jiale Wang, Xueying Wan, Yue Liu, Xu Mao

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(2483) : AC(1079), Curcumin : CK(7239) : AC(3319)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Liver Damage: Drug-Induced : CK(651) : AC(285)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Problem Substances : NF-kappaB Inhibitor : CK(5952) : AC(3464), Paracetamol : CK(863) : AC(298)

Effect of Curcuma longa extract on serum inflammatory markers and MRI-based synovitis in knee osteoarthritis.

Pubmed Data : Phytomedicine. 2022 Dec 18 ;109:154616. Epub 2022 Dec 18. PMID: 36610110

Article Published Date : Dec 17, 2022

Authors : Zhiqiang Wang, Tania Winzenberg, Ambrish Singh, Dawn Aitken, Leigh Blizzard, Mikael Boesen, Edwin H G Oei, Tijmen A van Zadelhoff, Venkat Parameswaran, Changhai Ding, Robert Jones, Benny Antony

Study Type : Human Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Osteoprotective : CK(2037) : AC(685)

Effect of essential oils from ginger and turmeric rhizomes on some inflammatory biomarkers in cadmium induced neurotoxicity in rats.

Pubmed Data : J Toxicol. 2018 ;2018:4109491. Epub 2018 Oct 8. PMID: 30402094

Article Published Date : Dec 31, 2017

Authors : Ayodele Jacob Akinyemi, Philip Adeyemi Adeniyi

Study Type : Animal Study

Additional Links

Substances : Ginger : CK(1593) : AC(479), Turmeric : CK(9427) : AC(3904)

Diseases : Cadmium Poisoning : CK(439) : AC(225)

Pharmacological Actions : Acetylcholinesterase Inhibitor : CK(259) : AC(128), Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-10 downregulation : CK(367) : AC(136), Interleukin-6 Downregulation : CK(9337) : AC(3613), Neuroprotective Agents : CK(20061) : AC(7949), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Additional Keywords : Essential Oils : CK(1005) : AC(429)

Problem Substances : Cadmium : CK(600) : AC(268)

Effectiveness of the integration of quercetin, turmeric, and N-acetylcysteine in reducing inflammation and pain associated with endometriosis.

Pubmed Data : Minerva Ginecol. 2020 Sep 14. Epub 2020 Sep 14. PMID: 32921020

Article Published Date : Sep 13, 2020

Authors : Mario Fadin, Maria Celeste Nicoletti, Marzia Pellizzato, Manuela Accardi, Maria Grazia Baiett

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine) : CK(1429) : AC(366), Quercetin : CK(1876) : AC(855), Turmeric : CK(9427) : AC(3904)

Diseases : Endometriosis : CK(579) : AC(159), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Effects of Astragaloside IV on treatment of breast cancer cells execute possibly through regulation of Nrf2.

Pubmed Data : Food Sci Nutr. 2019 Nov ;7(11):3403-3413. Epub 2019 Sep 18. PMID: 31762993

Article Published Date : Oct 31, 2019

Authors : Xiao-Qing Zhang, Chang Yao, Wei-He Bian, Xu Chen, Jing-Xian Xue, Zhi-Yuan Zhu, Yu Ying, Yan Lei Xu, Cong Wang

Study Type : In Vitro Study

Additional Links

Substances : Astragaloside : CK(843) : AC(453), Astragalus : CK(1267) : AC(578), Rhubarb : CK(183) : AC(77), Turmeric : CK(9427) : AC(3904)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210), Amyotrophic Lateral Sclerosis : CK(803) : AC(216), Brain: Microglial Activation : CK(205) : AC(118), Brain Inflammation : CK(1784) : AC(928), Multiple Sclerosis : CK(2432) : AC(557), Parkinson's Disease : CK(3012) : AC(1116)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Nrf2 activation : CK(3156) : AC(1794)

Effects of Curcuma comosa on the expression of atherosclerosis-related cytokine genes.

Pubmed Data : J Ethnopharmacol. 2011 Apr 12 ;134(3):608-13. Epub 2011 Jan 11. PMID: 21232590

Article Published Date : Apr 11, 2011

Authors : Puttavee Charoenwanthanang, Somsong Lawanprasert, Laddawal Phivthong-Ngam, Pawinee Piyachaturawat, Yupin Sanvarinda, Sureerut Porntadavity

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Atherosclerosis : CK(2063) : AC(778), High Cholesterol : CK(3091) : AC(530)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Effects of curcumin on microglial cells.

Pubmed Data : Neurotox Res. 2019 Jul ;36(1):12-26. Epub 2019 Apr 4. PMID: 30949950

Article Published Date : Jun 30, 2019

Authors : Faezeh Ghasemi, Hossein Bagheri, George E Barreto, Morgayn I Read, Amirhossein Sahebkar

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Immunomodulatory : CK(6531) : AC(2360), Neuroprotective Agents : CK(20061) : AC(7949)

Effects of curcuminoids on inflammatory and oxidative stress biomarkers and clinical outcomes in critically ill patients.

Pubmed Data : Phytother Res. 2021 Jun 2. Epub 2021 Jun 2. PMID: 34080237

Article Published Date : Jun 01, 2021

Authors : Hoda Zahedi, Mohammad Javad Hosseinzadeh-Attar, Mahdi Shadnoush, Amirhossein Sahebkar, Bahareh Barkhidarian, Omid Sadeghi, Atabak Najafi, Saeed Hosseini, Mostafa Qorbani, Arezoo Ahmadi, Seyed Hossein Ardehali, Abdolreza Norouzy

Study Type : Human Study

Additional Links

Substances : Curcuminoids : CK(7851) : AC(3498)

Diseases : Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Effects of mediterranean diet, curcumin, and resveratrol on mild-to-moderate active ulcerative colitis.

Pubmed Data : Nutrients. 2024 May 16 ;16(10). Epub 2024 May 16. PMID: 38794742

Article Published Date : May 15, 2024

Authors : Özge Erol Doğan, Kezban Esen KaracaÇelik, Murat Baş, Eyüp Hakan Alan, Yasir Furkan Çağın

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Resveratrol : CK(3228) : AC(1513)

Diseases : Ulcerative Colitis : CK(1411) : AC(447)

Therapeutic Actions : Dietary Modification: Mediterranean Diet : CK(1804) : AC(216)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Gastrointestinal Agents : CK(7657) : AC(2274)

Effects of nanocurcumin supplementation on metabolic syndrome.

Pubmed Data : Pharmacol Res. 2025 Mar ;213:107641. Epub 2025 Feb 1. PMID: 39894187

Article Published Date : Feb 28, 2025

Authors : Gofarana Wilar, Cecep Suhandi, Kohji Fukunaga, Masanori Shigeno, Ichiro Kawahata, Rizky Abdulah, Takuya Sasaki

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Hypertension : CK(9125) : AC(1361), Metabolic Syndrome X : CK(3095) : AC(546)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antihypertensive Agents : CK(7081) : AC(1029), Antioxidants : CK(34551) : AC(14499), Hypolipidemic : CK(9173) : AC(2038), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Effects of the curcuminoid and non-curcuminoid compounds of turmeric on the gut microbiome and inflammation.

Pubmed Data : Nutr Rev. 2025 Jan 28. Epub 2025 Jan 28. PMID: 39873671

Article Published Date : Jan 27, 2025

Authors : Claire Kacena

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Curcuminoids : CK(7851) : AC(3498), Turmeric : CK(9427) : AC(3904)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Effects of turmeric and its constituent curcumin on the metabolic syndrome.

Pubmed Data : J Integr Med. 2022 05 ;20(3):193-203. Epub 2022 Mar 1. PMID: 35292209

Article Published Date : Dec 31, 2021

Authors : Zeinab Vafaeipour, Bibi Marjan Razavi, Hossein Hosseinzadeh

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Diabetes Mellitus: Type 2 : CK(12953) : AC(2579)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antihypertensive Agents : CK(7081) : AC(1029), Antioxidants : CK(34551) : AC(14499), Hypolipidemic : CK(9173) : AC(2038)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Efficacy and safety of dietary polyphenols in rheumatoid arthritis.

Pubmed Data : Front Immunol. 2023 ;14:1024120. Epub 2023 Mar 22. PMID: 37033930

Article Published Date : Dec 31, 2022

Authors : Zhiyong Long, Wang Xiang, Qi He, Wei Xiao, Huagen Wei, Hao Li, Hua Guo, Yuling Chen, Mengxia Yuan, Xiao Yuan, Liuting Zeng, Kailin Yang, Yuxuan Deng, Zhen Huang

Study Type : Meta Analysis

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Hesperidin : CK(953) : AC(360), Olive : CK(1539) : AC(558), Quercetin : CK(1876) : AC(855), Resveratrol : CK(3228) : AC(1513)

Diseases : Rheumatoid Arthritis : CK(2322) : AC(562)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Efficacy and safety of tetrahydrocurcuminoids for the treatment of canker sore and gingivitis.

Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:6611877. Epub 2020 Dec 16. PMID: 33381205

Article Published Date : Dec 31, 2019

Authors : Muhammed Majeed, Shaheen Majeed, Kalyanam Nagabhushanam

Study Type : Human Study

Additional Links

Substances : Curcuminoids : CK(7851) : AC(3498)

Diseases : Canker Sore : CK(31) : AC(4), Gingivitis : CK(628) : AC(90)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Efficacy of a proprietary combination of Tamarindus indica seeds and Curcuma longa rhizome extracts in osteoarthritis.

Pubmed Data : Food Nutr Res. 2023 ;67. Epub 2023 Jun 20. PMID: 37351019

Article Published Date : Dec 31, 2022

Authors : Nandlal Prasad, Vineet Vinay, Anupam Srivastava

Study Type : Human Study

Additional Links

Substances : Tamarind : CK(143) : AC(41), Turmeric : CK(9427) : AC(3904)

Pharmacological Actions : Analgesics : CK(9680) : AC(1472), Anti-Inflammatory Agents : CK(39737) : AC(15858)

Efficacy of a standardized turmeric extract comprised of 70% bisdemothoxy-curcumin against LPS-induced inflammation.

Pubmed Data : J Inflamm Res. 2021 ;14:859-868. Epub 2021 Mar 12. PMID: 33737826

Article Published Date : Dec 31, 2020

Authors : Kuluvar Gouthamchandra, Heggar Venkataramana Sudeep, Siddappa Chandrappa, Amrith Raj, Puttaswamy Naveen, Kodimule Shyamaprasad

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Inflammation : CK(16108) : AC(5498), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Efficacy of dietary supplements in inflammatory bowel disease and related autoimmune diseases.

Pubmed Data : Nutrients. 2020 Jul 20 ;12(7). Epub 2020 Jul 20. PMID: 32698454

Article Published Date : Jul 19, 2020

Authors : Priyanka Jadhav, Yan Jiang, Karolin Jarr, Cosima Layton, Judith F Ashouri, Sidhartha R Sinha

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Fish Oil : CK(1152) : AC(187), Vitamin D : CK(11762) : AC(1712)

Diseases : Autoimmune Diseases : CK(12040) : AC(2692), Inflammatory Bowel Diseases : CK(3196) : AC(926), Psoriasis : CK(922) : AC(255), Rheumatoid Arthritis : CK(2322) : AC(562)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Enhancement of curcumin anti-inflammatory effect via formulation into myrrh oil-based nanoemulgel.

Pubmed Data : Polymers (Basel). 2021 Feb 14 ;13(4). Epub 2021 Feb 14. PMID: 33672981

Article Published Date : Feb 13, 2021

Authors : Wafaa E Soliman, Tamer M Shehata, Maged E Mohamed, Nancy S Younis, Heba S Elsewedy

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Myrrh : CK(133) : AC(61)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Epigenetics/epigenomics and prevention by curcumin of early stages of inflammatory-driven colon cancer.

Pubmed Data : Mol Carcinog. 2020 Feb ;59(2):227-236. Epub 2019 Dec 9. PMID: 31820492

Article Published Date : Jan 31, 2020

Authors : Renyi Wu, Lujing Wang, Ran Yin, Rasika Hudlikar, Shanyi Li, Hsiao-Chen D Kuo, Rebecca Peter, Davit Sargsyan, Yue Guo, Xia Liu, Ah-Ng T Kong

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Colon Cancer : CK(1920) : AC(1203), Gastrointestinal Inflammation : CK(330) : AC(157)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Chemoprotective Agents : CK(4278) : AC(1621)

Additional Keywords : Epigenetic Modification In Cancer : CK(189) : AC(126)

Essential oil from waste leaves of Curcuma longa L. alleviates skin inflammation.

Pubmed Data : Inflammopharmacology. 2018 Feb 10. Epub 2018 Feb 10. PMID: 29429001

Article Published Date : Feb 09, 2018

Authors : Anant Kumar, Karishma Agarwal, Monika Singh, Archana Saxena, Pankaj Yadav, Anil Kumar Maurya, Anju Yadav, Sudeep Tandon, Debabrata Chanda, Dnyaneshwar U Bawankule

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Additional Keywords : Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806), Essential Oils : CK(1005) : AC(429), Inflammation : CK(128) : AC(57), Inflammation : CK(128) : AC(57)

Exploring the anti-inflammatory effects of curcumin encapsulated within ferritin nanocages: a comprehensive in vivo and in vitro study in Alzheimer's disease.

Pubmed Data : J Nanobiotechnology. 2024 Nov 17 ;22(1):718. Epub 2024 Nov 17. PMID: 39551771

Article Published Date : Nov 16, 2024

Authors : Carlo Morasso, Marta Truffi, Veronica Tinelli, Polychronis Stivaktakis, Rosalinda Di Gerlando, Dragoni Francesca, Giulia Perini, Mahvish Faisal, Jana Aid, Bekzod Noridov, Benjamin Lee, Linda Barbieri, Sara Negri, Dragana Nikitovic, Lydia-Nefeli Thrapsanioti, Aristides Tsatsakis, Cristina Cereda, Arianna Bonizzi, Serena Mazzucchelli, Davide Prosperi, Miriam A Hickey, Fabio Corsi, Stella Gagliardi

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949)

Extracts of turmeric play an important role in the regulation of inflammatory reactions and oxidative stress occurring in the overweight patients.

Pubmed Data : Curr Med Chem. 2016 Nov 17. Epub 2016 Nov 17. PMID: 27855627

Article Published Date : Nov 16, 2016

Authors : Agata Jarząb, Wirginia Kukula-Koch

Study Type : Review

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Inflammation : CK(16108) : AC(5498), Obesity : CK(11004) : AC(2672), Overweight : CK(12956) : AC(2796)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Fast pain relief in exercise-induced acute musculoskeletal pain by turmeric-boswellia formulation.

Pubmed Data : Medicine (Baltimore). 2022 Sep 2 ;101(35):e30144. PMID: 36107505

Article Published Date : Sep 01, 2022

Authors : Girish H Rudrappa, Meghana Murthy, Santosh Saklecha, Sanjeev Kumar Kare, Ajay Gupta, Indraneel Basu

Study Type : Human Study

Additional Links

Substances : Frankincense : CK(1021) : AC(260), Turmeric : CK(9427) : AC(3904)

Diseases : Muscle Damage: Exercise-Induced : CK(1101) : AC(137)

Pharmacological Actions : Analgesics : CK(9680) : AC(1472), Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Fermentation with lactic acid bacteria increases the curcumin content of turmeric without increasing its cytotoxicity.

Pubmed Data : J Microbiol Biotechnol. 2019 Oct 28 ;29(10):1561-1569. PMID: 31434176

Article Published Date : Oct 27, 2019

Authors : Cheng Chung Yong, Yonghee Yoon, Hee Sub Yoo, Sejong Oh

Study Type : In Vitro Study

Additional Links

Substances : Fermented Foods and Beverages : CK(3367) : AC(829), Turmeric : CK(9427) : AC(3904)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Findings highlight the therapeutic potential of these compounds in mitigating tissue damage and inflammation associated with ovarian transplant.

Pubmed Data : Exp Clin Transplant. 2024 Sep ;22(9):706-716. PMID: 39431839

Article Published Date : Aug 31, 2024

Authors : Papatya Keles, Tansel Sapmaz, Kubra Basol Baki, Sude Topkaraoglu, Esra Erdem, Kubra Sevgin, Sibel Kuras, Mahmud Esad Pence, Selman Aktas, Burak Karip

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Gallic Acid : CK(341) : AC(212)

Diseases : Organ Transplantation : CK(59) : AC(24), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Interleukin-6 Downregulation : CK(9337) : AC(3613)

Formulated curcumin prevents paclitaxel-induced peripheral neuropathy.

Pubmed Data : Pharmaceutics. 2022 Jun 17 ;14(6). Epub 2022 Jun 17. PMID: 35745868

Article Published Date : Jun 16, 2022

Authors : Martial Caillaud, Danielle Thompson, Wisam Toma, Alyssa White, Jared Mann, Jane L Roberts, John W Bigbee, David A Gewirtz, M Imad Damaj

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Chemotherapy-Induced Toxicity: Paclitaxel : CK(173) : AC(55), Chemotherapy-Induced Toxicity: Peripheral Neuropathy : CK(340) : AC(62)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Chemoprotective Agents : CK(4278) : AC(1621), Neuroprotective Agents : CK(20061) : AC(7949)

Ginger and turmeric rhizomes decreased the anti-inflammatory cytokines in hypertensive rats.

Pubmed Data : Planta Med. 2016 Mar 22. Epub 2016 Mar 22. PMID: 27002391

Article Published Date : Mar 21, 2016

Authors : Ayodele Jacob Akinyemi, Gustavo Roberto Thomé, Vera Maria Morsch, Nathieli B Bottari, Jucimara Baldissarelli, Lizielle Souza de Oliveira, Jeferson Ferraz Goularte, Adriane Belló-Klein, Thiago Duarte, Marta Duarte, Aline Augusti Boligon, Margareth Linde Athayde, Akintunde Afolabi Akindahunsi, Ganiyu Oboh, Maria Rosa Chitolina Schetinger

Study Type : Animal Study

Additional Links

Substances : Ginger : CK(1593) : AC(479), Turmeric : CK(9427) : AC(3904)

Diseases : Hypertension : CK(9125) : AC(1361), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-10 downregulation : CK(367) : AC(136), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Glutamine and arginine-fortified PF with curcumin might be a promising option to enhance the effectiveness and expand the scope of EEN therapy.

Pubmed Data : JPEN J Parenter Enteral Nutr. 2016 Jan 29. Epub 2016 Jan 29. PMID: 26826259

Article Published Date : Jan 28, 2016

Authors : Moftah H Alhagamhmad, Andrew S Day, Daniel A Lemberg, Steven T Leach

Study Type : In Vitro Study

Additional Links

Substances : Arginine : CK(1147) : AC(201), Curcumin : CK(7239) : AC(3319), Glutamine : CK(207) : AC(38), Vitamin D : CK(11762) : AC(1712)

Diseases : Crohn's Disease : CK(242) : AC(55), Inflammatory Bowel Diseases : CK(3196) : AC(926)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-8 downregulation : CK(1107) : AC(402)

HCA may be of therapeutic potential for atopic dermatitis as it acts by suppressing keratinocyte activation.

Pubmed Data : PLoS One. 2016 ;11(3):e0150952. Epub 2016 Mar 9. PMID: 26959360

Article Published Date : Dec 31, 2015

Authors : Hyun-Su Lee, Eun-Ju Choi, Kyung-Sik Lee, Hye-Ran Kim, Bo-Ra Na, Min-Sung Kwon, Gil-Saeng Jeong, Hyun Gyu Choi, Eun Young Choi, Chang-Duk Jun

Study Type : Animal Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Atopic Dermatitis : CK(2139) : AC(366)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360)

Hepatoprotective effect of curcumin nano-lipid carrier against cypermethrin toxicity.

Pubmed Data : Molecules. 2023 Jan 16 ;28(2). Epub 2023 Jan 16. PMID: 36677938

Article Published Date : Jan 15, 2023

Authors : Sohail Hussain, Mohammad Ashafaq, Saeed Alshahrani, Ibrahim A M Bokar, Rahimullah Siddiqui, Mohammad Intakhab Alam, Manal Mohamed Elhassan Taha, Yosif Almoshari, Saad S Alqahtani, Rayan A Ahmed, Abdulmajeed M Jali, Marwa Qadri

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Oxidative Stress : CK(14758) : AC(5716), Pesticide Toxicity : CK(1467) : AC(478)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Interleukin-6 Downregulation : CK(9337) : AC(3613), NF-kappaB Inhibitor : CK(5952) : AC(3464), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Problem Substances : Pesticides : CK(2401) : AC(488)

Hepatoprotective effects of albumin-encapsulated nanoparticles of a curcumin derivative COP-22 against lipopolysaccharide/D-galactosamine-induced acute liver injury.

Pubmed Data : Int J Mol Sci. 2022 Apr 28 ;23(9). Epub 2022 Apr 28. PMID: 35563293

Article Published Date : Apr 27, 2022

Authors : Wenwen Mu, Qi Wang, Mingxia Jia, Sijia Dong, Sijie Li, Jie Yang, Guoyun Liu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875), Liver Damage : CK(4109) : AC(1872)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Herbal anti-inflammatory agents for skin disease.

Pubmed Data : Skin Therapy Lett. 2000 ;5(4):3-5. PMID: 10785407

Article Published Date : Jan 01, 2000

Authors : J Graf

Study Type : Review

Additional Links

Substances : Bromelain : CK(375) : AC(120), Capsaicin : CK(338) : AC(129), Turmeric : CK(9427) : AC(3904)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Phytotherapy : CK(4003) : AC(1031), Plant Extracts : CK(18762) : AC(6782)

Herbal formulation turmeric extract, black pepper, and ginger versus naproxen for chronic knee osteoarthritis.

Pubmed Data : Phytother Res. 2020 Aug ;34(8):2067-2073. Epub 2020 Mar 16. PMID: 32180294

Article Published Date : Jul 31, 2020

Authors : Motahar Heidari-Beni, Amir R Moravejolahkami, Pegah Gorgian, Gholamreza Askari, Mohammad J Tarrahi, Nimah Bahreini-Esfahani

Study Type : Human Study

Additional Links

Substances : Black Pepper : CK(735) : AC(333), Ginger : CK(1593) : AC(479), Turmeric : CK(9427) : AC(3904)

Diseases : Osteoarthritis: Knee : CK(2345) : AC(276)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Postaglandin PGE2 downregulation : CK(386) : AC(199)

Additional Keywords : Natural Substances Versus Drugs : CK(2806) : AC(560)

Herbals might play an important role in preserving the integrity of various neurotransmitters.

Pubmed Data : Adv Neurobiol. 2016;12:107-123. PMID: 27651251

Article Published Date : Dec 31, 2015

Authors : Pranay Srivastava, Rajesh Singh Yadav

Study Type : Review

Additional Links

Substances : Amla Fruit : CK(265) : AC(94), Ashwagandha : CK(748) : AC(301), Bacopa : CK(337) : AC(153), Gotu Kola : CK(295) : AC(124), Holy Basil : CK(261) : AC(109), Spikenard : CK(39) : AC(23), Turmeric : CK(9427) : AC(3904)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210), Neurodegenerative Diseases : CK(13103) : AC(4279), Parkinson's Disease : CK(3012) : AC(1116)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD.

Pubmed Data : Int J Chron Obstruct Pulmon Dis. 2016 ;11:2029-34. Epub 2016 Aug 26. PMID: 27616885

Article Published Date : Dec 31, 2015

Authors : Masafumi Funamoto, Yoichi Sunagawa, Yasufumi Katanasaka, Yusuke Miyazaki, Atsushi Imaizumi, Hideaki Kakeya, Hajime Yamakage, Noriko Satoh-Asahara, Maki Komiyama, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Atherosclerosis : CK(2063) : AC(778), Cholesterol: Oxidation : CK(654) : AC(159), Chronic Obstructive Pulmonary Disease : CK(1617) : AC(252)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anticholesteremic Agents : CK(4093) : AC(669)

Hypolipidemic and anti-inflammatory effects of Curcuma longa-derived bisacurone in high-fat diet.

Pubmed Data : Int J Mol Sci. 2023 May 27 ;24(11). Epub 2023 May 27. PMID: 37298318

Article Published Date : May 26, 2023

Authors : Chaoqi He, Taiki Miyazawa, Chizumi Abe, Takahiro Ueno, Mikiko Suzuki, Masashi Mizukami, Kazue Kurihara, Masako Toda

Study Type : Animal Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : High Fat Diet : CK(2040) : AC(984), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613), NF-kappaB Inhibitor : CK(5952) : AC(3464), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Immune-boosting, antioxidant and anti-inflammatory food supplements targeting pathogenesis of COVID-19.

Pubmed Data : Front Immunol. 2020 ;11:570122. Epub 2020 Oct 7. PMID: 33117359

Article Published Date : Dec 31, 2019

Authors : M Mrityunjaya, V Pavithra, R Neelam, P Janhavi, P M Halami, P V Ravindra

Study Type : In Vitro Study

Additional Links

Substances : Cinnamaldehyde : CK(213) : AC(130), Curcumin : CK(7239) : AC(3319), Lactoferrin : CK(813) : AC(308), Probiotics : CK(9740) : AC(1711), Selenium : CK(1753) : AC(393), Vitamin C : CK(6066) : AC(1408), Vitamin D : CK(11762) : AC(1712), Zinc : CK(1957) : AC(345)

Diseases : Coronavirus Infection : CK(3250) : AC(986)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunostimulatory : CK(772) : AC(235)

Immunomodulatory and anti-inflammatory potential of curcumin for the treatment of allergic asthma.

Pubmed Data : Inflammation. 2019 Dec ;42(6):2037-2047. PMID: 31407145

Article Published Date : Nov 30, 2019

Authors : Hira Shahid, Muhammad Shahzad, Arham Shabbir, Gulpash Saghir

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Asthma : CK(3242) : AC(707)

Pharmacological Actions : Anti-Asthmatic Agents : CK(510) : AC(148), Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360), Interleukin-4 downregulation : CK(460) : AC(173), Interleukin-5 downregulation : CK(154) : AC(65), Transforming growth factor beta (TGF-β) inhibitor : CK(580) : AC(292), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Immunomodulatory effect of curcumin on hepatic cirrhosis in experimental rats.

Pubmed Data : J Food Biochem. 2020 Mar 25:e13219. Epub 2020 Mar 25. PMID: 32215945

Article Published Date : Mar 24, 2020

Authors : Mabrouk A Abo-Zaid, Emad S Shaheen, Ahmed H Ismail

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Liver Cirrhosis : CK(919) : AC(230)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360), Interleukin-10 upregulation : CK(1296) : AC(436), Transforming growth factor beta (TGF-β) inhibitor : CK(580) : AC(292)

Immunomodulatory effect of curcumin on lipopolysaccharide- and/or flagellin-induced production of prostaglandin E2 and relative expression of proinflammatory cytokines.

Pubmed Data : Reprod Domest Anim. 2019 Jun ;54(6):917-923. Epub 2019 May 10. PMID: 30972855

Article Published Date : May 31, 2019

Authors : Rouf Rashid Dar, Ajaz Ali, Sheikh Firdous Ahmad, Sanjay Kumar Singh, Manas Kumar Patra, Manjit Panigrahi, Harendra Kumar, Narayanan Krishnaswamy

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Endometritis : CK(86) : AC(32), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360), Prostaglandin PGE2 downregulation : CK(194) : AC(89)

Immunoregulatory effects of nanocurcumin in inflammatory milieu: Focus on COVID-19.

Pubmed Data : Biomed Pharmacother. 2024 Feb ;171:116131. Epub 2024 Jan 9. PMID: 38198954

Article Published Date : Jan 31, 2024

Authors : Fahimeh Lavi Arab, Akram Hoseinzadeh, Fatemeh Sadat Mohammadi, Arezoo Rajabian, Arezoo Faridzadeh, Mahmoud Mahmoudi

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Coronavirus Disease (Covid-19) : CK(1328) : AC(329)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Impact of curcumin, quercetin, or resveratrol on the pathophysiology of endometriosis.

Pubmed Data : Phytother Res. 2022 Jun ;36(6):2416-2433. Epub 2022 May 18. PMID: 35583746

Article Published Date : May 31, 2022

Authors : Mariana Hipólito-Reis, Ana Catarina Neto, Delminda Neves

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Quercetin : CK(1876) : AC(855), Resveratrol : CK(3228) : AC(1513)

Diseases : Endometriosis : CK(579) : AC(159)

Pharmacological Actions : Angiogenesis Inhibitors : CK(724) : AC(481), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Antiproliferative : CK(10001) : AC(7491)

Impacts of curcumin treatment on experimental sepsis.

Pubmed Data : Oxid Med Cell Longev. 2023 ;2023:2252213. Epub 2023 Jan 30. PMID: 36756300

Article Published Date : Dec 31, 2022

Authors : Barbara Martins Vieira, Marcos Antonio Ferreira Caetano, Mara Taís de Carvalho, Felipe Dos Santos Arruda, Fernanda Dias Tomé, Jordana Fernandes de Oliveira, Danilo Figueiredo Soave, Jonathas Xavier Pereira, Mara Rubia Nunes Celes

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Oxidative Stress : CK(14758) : AC(5716), Sepsis : CK(1436) : AC(491)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Immunomodulatory : CK(6531) : AC(2360)

Inhibition of curcumin on influenza A virus infection and influenzal pneumonia.

Pubmed Data : Int Immunopharmacol. 2018 Jan ;54:177-187. Epub 2017 Nov 15. PMID: 29153953

Article Published Date : Dec 31, 2017

Authors : Jianping Dai, Liming Gu, Yun Su, Qianwen Wang, Ying Zhao, Xiaoxua Chen, Huixiong Deng, Weizhong Li, Gefei Wang, Kangsheng Li

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Influenza A : CK(582) : AC(204), Oxidative Stress : CK(14758) : AC(5716), Pneumonia : CK(1101) : AC(171)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Antiviral Agents : CK(3095) : AC(1702), Nrf2 activation : CK(3156) : AC(1794)

Inhibitory effects of phytochemicals on NLRP3 inflammasome activation.

Pubmed Data : Phytomedicine. 2020 Aug 15 ;75:153238. Epub 2020 May 20. PMID: 32507349

Article Published Date : Aug 14, 2020

Authors : Melis Olcum, Bora Tastan, Ilkcan Ercan, Irem B Eltutan, Sermin Genc

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Resveratrol : CK(3228) : AC(1513), Sulforaphane : CK(1344) : AC(630)

Diseases : Cardiovascular Diseases : CK(17333) : AC(2878), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Intragastric administration of curcumin inhibited the experimentally induced murine colitis.

Pubmed Data : J Cancer Prev. 2018 Mar ;23(1):18-24. Epub 2018 Mar 30. PMID: 29629345

Article Published Date : Feb 28, 2018

Authors : Joon-Yeop Yang, Xiancai Zhong, Su-Jung Kim, Do-Hee Kim, Hyun Soo Kim, Jeong-Sang Lee, Hye-Won Yum, Jeewoo Lee, Hye-Kyung Na, Young-Joon Surh

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Colitis : CK(1542) : AC(735)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), NF-kappaB Inhibitor : CK(5952) : AC(3464), STAT3 Inhibitor : CK(322) : AC(216)

Intranasal curcumin alleviate paraquat induced pulmonary damage and pro-inflammatory cytokine levels like tumor necrosis factor-α (TNF-α) and nitric oxide (NO).

Pubmed Data : Environ Toxicol Pharmacol. 2014 Nov ;38(3):913-21. Epub 2014 Oct 18. PMID: 25461551

Article Published Date : Oct 31, 2014

Authors : Namitosh Tyagi, Asha Kumari, D Dash, Rashmi Singh

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Herbicide Toxicity : CK(68) : AC(23), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Nitric Oxide Inhibitor : CK(705) : AC(356), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Intrathecal curcumin attenuates arthritic pain by inhibiting glial activation and the production of inflammatory mediators in the spinal cord.

Pubmed Data : Sci Rep. 2015 ;5:10278. Epub 2015 May 19. PMID: 25988362

Article Published Date : Dec 31, 2014

Authors : Jun-Jie Chen, Lin Dai, Lin-Xia Zhao, Xiang Zhu, Su Cao, Yong-Jing Gao

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Arthritis : CK(5826) : AC(1505), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940)

Additional Keywords : Dose Response : CK(1770) : AC(700)

Is curcumin useful in the treatment and prevention of the tendinopathy and myotendinous junction injury.

Pubmed Data : Nutrients. 2023 Jan 12 ;15(2). Epub 2023 Jan 12. PMID: 36678255

Article Published Date : Jan 11, 2023

Authors : Alfredo Córdova, Franchek Drobnic, David Noriega-González, Alberto Caballero-García, Enrique Roche, Melchor Alvarez-Mon

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Inflammation : CK(16108) : AC(5498), Tendinopathy : CK(164) : AC(27)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Liposomal curcumin could be a promising intervention for asthma therapy.

Pubmed Data : Colloids Surf B Biointerfaces. 2018 Aug 16 ;172:51-59. Epub 2018 Aug 16. PMID: 30134219

Article Published Date : Aug 15, 2018

Authors : Zhao Yin Ng, Jin-Ying Wong, Jithendra Panneerselvam, Thiagarajan Madheswaran, Pradeep Kumar, Viness Pillay, Alan Hsu, Nicole Hansbro, Mary Bebawy, Peter Wark, Philip Hansbro, Kamal Dua, Dinesh Kumar Chellappan

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Asthma : CK(3242) : AC(707)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Interleukin-8 downregulation : CK(1107) : AC(402), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Liposomal curcumin inhibits cigarette smoke induced senescence and inflammation in human bronchial epithelial cells.

Pubmed Data : Pathol Res Pract. 2024 Aug ;260:155423. Epub 2024 Jun 20. PMID: 38909404

Article Published Date : Jul 31, 2024

Authors : Sofia Kokkinis, Gabriele De Rubis, Keshav Raj Paudel, Vyoma K Patel, Stewart Yeung, Victoria Jessamine, Ronan MacLoughlin, Philip M Hansbro, Brian Oliver, Kamal Dua

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Chronic Obstructive Pulmonary Disease : CK(1617) : AC(252), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Liposomal curcumin may be useful for the prevention of copper sulphate induced liver injury.

Pubmed Data : Dose Response. 2018 Jul-Sep;16(3):1559325818790869. Epub 2018 Aug 9. PMID: 30116168

Article Published Date : Jun 30, 2018

Authors : Ahlam Alhusaini, Laila Fadda, Iman Hassan, Hanaa M Ali, Njood Alsaadan, Nouf Aldowsari, Azizah Aldosari, Bshayer Alharbi

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Copper Toxicity : CK(49) : AC(23)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Additional Keywords : Natural Substances Versus Drugs : CK(2806) : AC(560)

Liposomal curcumin might be a promising tool for the treatment of inflammatory diseases.

Pubmed Data : In Vivo. 2016 07-08;30(4):413-419. PMID: 27381602

Article Published Date : Dec 31, 2015

Authors : Burkhard Kloesch, Lukas Gober, Silvia Loebsch, Brigitta Vcelar, Lawrence Helson, Guenter Steiner

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Additional Keywords : Liposomal Curcumin : CK(22) : AC(11)

Liposomes are a new strategy to target lipid rich inflammatory dendritic cells and have potential to deliver immunomodulatory compounds to treat NASH.

Pubmed Data : Metabolism. 2018 01 ;78:80-94. Epub 2017 Sep 20. PMID: 28941597

Article Published Date : Dec 31, 2017

Authors : Muralidhara Rao Maradana, Suman Kumar Yekollu, Bijun Zeng, Jonathan Ellis, Andrew Clouston, Gregory Miller, Meghna Talekar, Zaied Ahmed Bhuyan, Sachin Mahadevaiah, Elizabeth E Powell, Katharine M Irvine, Ranjeny Thomas, Brendan John O'Sullivan

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Vitamin D : CK(11762) : AC(1712)

Diseases : Inflammation : CK(16108) : AC(5498), Insulin Resistance : CK(4864) : AC(1098), Liver Cirrhosis : CK(919) : AC(230)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Liposomal Curcumin : CK(22) : AC(11)

Lycopene combined with quercetin and curcumin for chronic prostatitis/chronic pelvic pain syndrome.

Pubmed Data : Zhonghua Nan Ke Xue. 2021 Feb ;27(2):99-105. PMID: 34914324

Article Published Date : Jan 31, 2021

Authors : Qin-Xin Zhao, Fei-Ya Yang, Dong Chen, Nian-Zeng Xing

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Lycopene : CK(1267) : AC(372), Quercetin : CK(1876) : AC(855)

Diseases : Prostatitis: Chronic : CK(157) : AC(28)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-2 Downregulation : CK(177) : AC(73), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Mangosteen pericarp extract and curcuma were independently and in combination effective in treating obesity-induced inflammation.

Pubmed Data : Nutrients. 2022 Nov 3 ;14(21). Epub 2022 Nov 3. PMID: 36364892

Article Published Date : Nov 02, 2022

Authors : Ranyah Shaker M Labban, Hanan A Alfawaz, Musarat Amina, Ramesa Shafi Bhat, Wail M Hassan, Afaf El-Ansary

Study Type : Animal Study

Additional Links

Substances : Mangosteen : CK(261) : AC(133), Turmeric : CK(9427) : AC(3904)

Diseases : High Fat Diet : CK(2040) : AC(984), Inflammation : CK(16108) : AC(5498), Obesity : CK(11004) : AC(2672)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949)

Additional Keywords : Anti-Obesity Agents : CK(5172) : AC(1320), Natural Substance Synergy : CK(1400) : AC(669), Plant Extracts : CK(18762) : AC(6782)

Mechanistic insights of hepatoprotective effects of curcumin.

Pubmed Data : Food Chem Toxicol. 2019 Feb ;124:182-191. Epub 2018 Dec 5. PMID: 30529260

Article Published Date : Jan 31, 2019

Authors : Haroon Khan, Hammad Ullah, Seyed M Nabavi

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Chemically-Induced Liver Damage : CK(2304) : AC(1089), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Medical therapy of asthenoteratospermia with curcumin nanomicelle supplement could improve quality of semen parameters.

Pubmed Data : Phytother Res. 2018 Mar ;32(3):514-521. Epub 2017 Nov 28. PMID: 29193350

Article Published Date : Feb 28, 2018

Authors : Fatemeh Alizadeh, Maryam Javadi, Ali Akbar Karami, Fereshteh Gholaminejad, Maria Kavianpour, Hossein Khadem Haghighian

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Infertility: Male : CK(1757) : AC(452)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Malondialdehyde Down-regulation : CK(3028) : AC(992), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Molecular mechanisms of curcumin in neuroinflammatory disorders.

Pubmed Data : Endocr Metab Immune Disord Drug Targets. 2019 ;19(3):247-258. PMID: 30488803

Article Published Date : Dec 31, 2018

Authors : Mahsa Hatami, Mina Abdolahi, Neda Soveyd, Mahmoud Djalali, Mansoureh Togha, Niyaz Mohammadzadeh Honarvar

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain Inflammation : CK(1784) : AC(928)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Neuroprotective Agents : CK(20061) : AC(7949), NF-kappaB Inhibitor : CK(5952) : AC(3464), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Molecular mechanisms underlying curcumin-mediated therapeutic effects in type 2 diabetes and cancer.

Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:9698258. Epub 2018 Mar 20. PMID: 29743988

Article Published Date : Dec 31, 2017

Authors : Marzena Wojcik, Michal Krawczyk, Pawel Wojcik, Katarzyna Cypryk, Lucyna Alicja Wozniak

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cancers: All : CK(36404) : AC(14363), Diabetes Mellitus: Type 2 : CK(12953) : AC(2579)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Antiproliferative : CK(10001) : AC(7491), Chemopreventive : CK(6580) : AC(2166), Hypoglycemic Agents : CK(9221) : AC(2076)

Multiple mechanisms of curcumin targeting spinal cord injury.

Pubmed Data : Biomed Pharmacother. 2023 Jan 14 ;159:114224. Epub 2023 Jan 14. PMID: 36641925

Article Published Date : Jan 13, 2023

Authors : Guangjin Gu, Jie Ren, Bin Zhu, Zhongju Shi, Shiqing Feng, Zhijian Wei

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Spinal Cord Injuries : CK(890) : AC(347)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Multitargeting effects of calebin A on malignancy of CRC Cells in multicellular tumor microenvironment.

Pubmed Data : Front Oncol. 2021 ;11:650603. Epub 2021 Sep 29. PMID: 34660256

Article Published Date : Dec 31, 2020

Authors : Constanze Buhrmann, Ajaikumar B Kunnumakkara, Aviral Kumar, Marek Samec, Peter Kubatka, Bharat B Aggarwal, Mehdi Shakibaei

Study Type : In Vitro Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Colorectal Cancer : CK(4889) : AC(2276)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antiproliferative : CK(10001) : AC(7491)

Additional Keywords : Tumor Microenvironment : CK(170) : AC(121)

Nanocurcumin formulation: a possible therapeutic agent for post COVID inflammatory syndrome.

Pubmed Data : Immunopharmacol Immunotoxicol. 2022 Feb 8:1-6. Epub 2022 Feb 8. PMID: 35130792

Article Published Date : Feb 07, 2022

Authors : Asha D Kushwaha, K P Mishra, Mrinalini Singh, Lilly Ganju, Deepika Saraswat

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Coronavirus Infection : CK(3250) : AC(986), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Nanocurcumin has a potentiating anti-inflammatory effect when combined with standard COVID-19 treatment.

Pubmed Data : Int J Clin Pract. 2023 ;2023:5734675. Epub 2023 Jul 28. PMID: 37547100

Article Published Date : Dec 31, 2022

Authors : Sedigheh Ahmadi, Zeinab Mehrabi, Morteza Zare, Sara Ghadir, Seyed Jalil Masoumi

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Coronavirus Infection : CK(3250) : AC(986)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Nanocurcumin in myocardial infarction therapy: emerging trends and future directions.

Pubmed Data : Front Bioeng Biotechnol. 2024 ;12:1511331. Epub 2025 Jan 8. PMID: 39845374

Article Published Date : Dec 31, 2023

Authors : Mei Lv, Qing Sun, Yilin Yu, Jinwei Bao

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Myocardial Infarction : CK(2132) : AC(509)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963)

Nanocurcumin potently inhibits SARS-CoV-2 spike protein-induced cytokine storm.

Pubmed Data : ACS Appl Bio Mater. 2022 02 21 ;5(2):483-491. Epub 2022 Feb 3. PMID: 35112841

Article Published Date : Jan 20, 2022

Authors : Vivek K Sharma, Prateeksha, Shailendra P Singh, Brahma N Singh, Chandana V Rao, Saroj K Barik

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Coronavirus Infection : CK(3250) : AC(986)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Cytokine Storm : CK(196) : AC(77)

Nanocurcumin preserves kidney function and haematology parameters in DMBA-induced ovarian cancer treated with cisplatin.

Pubmed Data : Pharm Biol. 2023 Dec ;61(1):298-305. PMID: 36708211

Article Published Date : Nov 30, 2023

Authors : Melva Louisa, Erico Wanafri, Wawaimuli Arozal, Ni Made Dwi Sandhiutami, Ahmad Muhammad Basalamah

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1246) : AC(601), Ovarian Cancer : CK(1029) : AC(509)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Chemoprotective Agents : CK(4278) : AC(1621), Renoprotective : CK(4544) : AC(1971)

Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin.

Pubmed Data : Colloids Surf B Biointerfaces. 2017 Feb 1 ;150:223-241. Epub 2016 Nov 30. PMID: 27918967

Article Published Date : Jan 31, 2017

Authors : Zahid Hussain, Hnin Ei Thu, Shiow-Fern Ng, Shahzeb Khan, Haliza Katas

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Natural herbs are safe, effective and better options as anti-inflammatory agents than synthetic ones.

Pubmed Data : Recent Pat Inflamm Allergy Drug Discov. 2018 Jan 15. Epub 2018 Jan 15. PMID: 29336271

Article Published Date : Jan 14, 2018

Authors : Mohd Iqbal Yatoo, Arumugam Gopalakrishnan, Archana Saxena, Oveas Rafiq Parray, Noore Alam Tufani, Sandip Chakraborty, Ruchi Tiwari, Kuldeep Dhama, Hafiz M N Iqbal

Study Type : Review

Additional Links

Substances : Blueberry : CK(1151) : AC(334), Cat's Claw : CK(61) : AC(28), Ginger : CK(1593) : AC(479), Nettle : CK(364) : AC(146), Olive : CK(1539) : AC(558), Turmeric : CK(9427) : AC(3904)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Natural products for promoting joint health and managing osteoarthritis.

Pubmed Data : Curr Rheumatol Rep. 2018 Sep 19 ;20(11):72. Epub 2018 Sep 19. PMID: 30232562

Article Published Date : Sep 18, 2018

Authors : Yves Henrotin, Ali Mobasheri

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Frankincense : CK(1021) : AC(260), Pycnogenol (Pine Bark) : CK(1254) : AC(223)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Nephroprotective effect of essential oils from ginger and turmeric rhizomes against cadmium-induced nephrotoxicity.

Pubmed Data : J Oleo Sci. 2018 ;67(10):1339-1345. PMID: 30305562

Article Published Date : Dec 31, 2017

Authors : Ayodele Jacob Akinyemi, Oluwabamise Lekan Faboya, Awonegan Ayodeji Paul, Israel Olayide, Opeyemi Ayodeji Faboya, Titus Ademola Oluwasola

Study Type : Animal Study

Additional Links

Substances : Ginger : CK(1593) : AC(479), Turmeric : CK(9427) : AC(3904)

Diseases : Kidney Damage: Chemically-Induced : CK(561) : AC(281)

Pharmacological Actions : Adenosine deaminase inhibitor : CK(20) : AC(7), Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-10 downregulation : CK(367) : AC(136), Interleukin-6 Downregulation : CK(9337) : AC(3613), Renoprotective : CK(4544) : AC(1971), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Additional Keywords : Essential Oils : CK(1005) : AC(429)

Problem Substances : Cadmium : CK(600) : AC(268)

Neuroinflammation in pathogenesis of Alzheimer's disease: phytochemicals as potential therapeutics.

Pubmed Data : Mech Ageing Dev. 2020 May 22:111259. Epub 2020 May 22. PMID: 32450086

Article Published Date : May 21, 2020

Authors : Alexander Vaiserman, Alexander Koliada, Oleh Lushchak

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Genistein : CK(945) : AC(434), Quercetin : CK(1876) : AC(855), Resveratrol : CK(3228) : AC(1513)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210), Brain Inflammation : CK(1784) : AC(928)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949)

Neuromodulatory effect of curcumin on catecholamine systems and inflammatory cytokines in ovariectomized female rats.

Pubmed Data : Clin Exp Pharmacol Physiol. 2020 Oct 24. Epub 2020 Oct 24. PMID: 33098686

Article Published Date : Oct 23, 2020

Authors : Nashwa M Saied, Gehan S Georgy, Rokaya M Hussien, Wafaa A Hassan

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain Inflammation : CK(1784) : AC(928), Depression : CK(9574) : AC(1756)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antidepressive Agents : CK(7908) : AC(1466), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Nitric Oxide Inhibitor : CK(705) : AC(356), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Non-invasive delivery of nano-emulsified sesame oil-extract of turmeric attenuates lung inflammation.

Pubmed Data : Pharmaceutics. 2020 Dec 11 ;12(12). Epub 2020 Dec 11. PMID: 33322573

Article Published Date : Dec 10, 2020

Authors : Sahibzada Tasleem Rasool, Rajasekhar Reddy Alavala, Umasankar Kulandaivelu, Nagaraja Sreeharsha

Study Type : Animal Study

Additional Links

Substances : Sesame Seed Oil : CK(277) : AC(44), Turmeric : CK(9427) : AC(3904)

Diseases : Lung Inflammation : CK(276) : AC(113)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), interleukin-13 down-regulation : CK(150) : AC(75), Interleukin-4 downregulation : CK(460) : AC(173), Interleukin-6 Downregulation : CK(9337) : AC(3613)

NPs-Cur enhance the action of curcumin on several pathways implicated in the pathophysiology of Alzheimer's disease.

Pubmed Data : Mol Pharm. 2015 Dec 23. Epub 2015 Dec 23. PMID: 26618861

Article Published Date : Dec 22, 2015

Authors : Ghislain Djiokeng Paka, Sihem Doggui, Ahlem Zaghmi, Ramia Safar, Lé Dao, Andreas Reisch, Andrey Klymchenko, V Gaëlle Roullin, Olivier Joubert, Charles Ramassamy

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Nutraceuticals employed in this study and their associations exert a positive action against Cd-induced testicular injury.

Pubmed Data : Pharmaceuticals (Basel). 2021 Apr 21 ;14(5). Epub 2021 Apr 21. PMID: 33919028

Article Published Date : Apr 20, 2021

Authors : Nadia Ferlazzo, Antonio Micali, Herbert Ryan Marini, Josè Freni, Giuseppe Santoro, Domenico Puzzolo, Francesco Squadrito, Giovanni Pallio, Michele Navarra, Santa Cirmi, Letteria Minutoli

Study Type : Animal Study

Additional Links

Substances : Bergamot : CK(153) : AC(66), Curcumin : CK(7239) : AC(3319), Flavonoids : CK(4698) : AC(2176), Resveratrol : CK(3228) : AC(1513)

Diseases : Testicular Injury: Chemical/Metal Induced : CK(774) : AC(385)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Problem Substances : Cadmium : CK(600) : AC(268)

Obesity may increase susceptibility to chronic pain often due to poor diet.

Pubmed Data : Eur J Pain. 2018 08 ;22(7):1203-1213. Epub 2018 Mar 2. PMID: 29436058

Article Published Date : Dec 31, 2017

Authors : S K Totsch, R Y Meir, T L Quinn, S A Lopez, B A Gower, R E Sorge

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), EGCG (Epigallocatechin gallate) : CK(1587) : AC(820), Ginseng : CK(4190) : AC(1902), Resveratrol : CK(3228) : AC(1513), Sulforaphane : CK(1344) : AC(630)

Diseases : Chronic Pain : CK(1524) : AC(284), Inflammation : CK(16108) : AC(5498), Obesity : CK(11004) : AC(2672)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Anti-Inflammatory Agents : CK(39737) : AC(15858), Risk Factors : CK(14901) : AC(2085)

Old but fancy: Curcumin in ulcerative colitis-current overview.

Pubmed Data : Nutrients. 2022 Dec 9 ;14(24). Epub 2022 Dec 9. PMID: 36558408

Article Published Date : Dec 08, 2022

Authors : Aleksandra Pituch-Zdanowska, Łukasz Dembiński, Aleksandra Banaszkiewicz

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Inflammation : CK(16108) : AC(5498), Ulcerative Colitis : CK(1411) : AC(447)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

OP-Gel-Aloe treated wounds exhibited very rapid healing with 80% of the wound healing in just 8 days.

Pubmed Data : Int J Biol Macromol. 2015 Oct 31. Epub 2015 Oct 31. PMID: 26529192

Article Published Date : Oct 30, 2015

Authors : Mythili Tummalapalli, Morgane Berthet, Bernard Verrier, B L Deopura, M S Alam, Bhuvanesh Gupta

Study Type : Animal Study

Additional Links

Substances : Aloe Vera : CK(940) : AC(254), Curcumin : CK(7239) : AC(3319), Pectin : CK(122) : AC(32)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antimicrobial : CK(1577) : AC(790)

Optimized curcumin, pomegranate extract, and methylsulfonylmethane reduce acute, systemic inflammatory response to a half-marathon race.

Pubmed Data : Altern Ther Health Med. 2020 Jul 1. Epub 2020 Jul 1. PMID: 32619204

Article Published Date : Jun 30, 2020

Authors : Elizabeth A Tanner, Melody A Gary, Stephan Michalik, Asheal A Davis, Brian K McFarlin

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), MSM (Methylsulfonylmethane) : CK(175) : AC(41), Pomegranate : CK(1800) : AC(573)

Diseases : Inflammation : CK(16108) : AC(5498), Muscle Damage: Exercise-Induced : CK(1101) : AC(137)

Therapeutic Actions : Exercise: Running : CK(613) : AC(73)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Oral administration of Curcuma longa associated with white pepper at doses that can be extrapolated to human exposure upon supplementation improves pro-inflammatory disorders.

Pubmed Data : PLoS One. 2013 ;8(11):e81252. Epub 2013 Nov 19. PMID: 24260564

Article Published Date : Dec 31, 2012

Authors : Audrey M Neyrinck, Maud Alligier, Patrick B Memvanga, Elodie Névraumont, Yvan Larondelle, Véronique Préat, Patrice D Cani, Nathalie M Delzenne

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Piperine : CK(600) : AC(258), White Pepper : CK(12) : AC(2)

Diseases : High Fat Diet : CK(2040) : AC(984), Inflammation : CK(16108) : AC(5498), Obesity : CK(11004) : AC(2672)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Additional Keywords : Dietary Concentrations : CK(115) : AC(25), Increased Bioavailability : CK(83) : AC(34), Plant Extracts : CK(18762) : AC(6782)

Oral administration of curcumin reduces inflammation in the first six hours after experimentally zymosan-induced arthritis.

Pubmed Data : Acta Cir Bras. 2014 Nov ;29(11):727-34. PMID: 25424293

Article Published Date : Oct 31, 2014

Authors : Nilson Nonose, José Aires Pereira, Paulo Roberto Moura Machado, Murilo Rocha Rodrigues, Daniela Tiemi Sato, Carlos Augusto Real Martinez

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Inflammation: Neutrophil-Mediated : CK(17) : AC(10), Rheumatoid Arthritis : CK(2322) : AC(562)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Natural Substances Versus Drugs : CK(2806) : AC(560)

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(3243) : AC(656)

Oral administration of curcumin reduces intestinal inflammation in a mouse model of irritable bowel syndrome.

Pubmed Data : Dig Dis Sci. 2010 May;55(5):1272-7. Epub 2009 Jun 10. PMID: 19513843

Article Published Date : May 01, 2010

Authors : Victoria Y L Ung, Rae R Foshaug, Sarah M MacFarlane, Thomas A Churchill, Jason S G Doyle, Beate C Sydora, Richard N Fedorak

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Colitis : CK(1542) : AC(735), Irritable Bowel Syndrome : CK(1492) : AC(230)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-10 downregulation : CK(367) : AC(136)

Oral administration of turmeric anthocyanin extract in O. viverrini-infected hamsters resulted in reduced inflammatory cells and periductal fibrosis.

Pubmed Data : Food Chem Toxicol. 2014 Dec ;74:206-15. PMID: 25447758

Article Published Date : Nov 30, 2014

Authors : Kitti Intuyod, Aroonsri Priprem, Wanwisa Limphirat, Lakhanawan Charoensuk, Porntip Pinlaor, Chawalit Pairojkul, Kamol Lertrat, Somchai Pinlaor

Study Type : Animal Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Flukes : CK(14) : AC(7), Parasitic Diseases : CK(140) : AC(72)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for murine colitis.

Pubmed Data : J Nanobiotechnology. 2022 Apr 29 ;20(1):206. Epub 2022 Apr 29. PMID: 35488343

Article Published Date : Apr 28, 2022

Authors : Cui Liu, Xiangji Yan, Yujie Zhang, Mei Yang, Yana Ma, Yuanyuan Zhang, Qiuran Xu, Kangsheng Tu, Mingzhen Zhang

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)

Diseases : Colitis : CK(1542) : AC(735), Inflammation : CK(16108) : AC(5498), Ulcerative Colitis : CK(1411) : AC(447)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Additional Keywords : Exosomes : CK(385) : AC(232)

Phytochemicals have the potential of modulating various molecular processes, including signaling pathways involved in the development and progression of tumors.

Pubmed Data : Onco Targets Ther. 2015 ;8:2053-66. Epub 2015 Aug 6. PMID: 26273208

Article Published Date : Dec 31, 2014

Authors : Roxana Cojocneanu Petric, Cornelia Braicu, Lajos Raduly, Oana Zanoaga, Nicolae Dragos, Paloma Monroig, Dan Dumitrascu, Ioana Berindan-Neagoe

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), EGCG (Epigallocatechin gallate) : CK(1587) : AC(820), Genistein : CK(945) : AC(434)

Substances : Andrographolide : CK(251) : AC(179), Apigenin : CK(681) : AC(392), Carnosic Acid : CK(167) : AC(112), Curcumin : CK(7239) : AC(3319), Ginsenosides : CK(2640) : AC(1452), Parthenolide : CK(203) : AC(142), Puerarin : CK(777) : AC(388), Quercetin : CK(1876) : AC(855), Resveratrol : CK(3228) : AC(1513), Wogonin : CK(214) : AC(146), Xanthohumol : CK(279) : AC(187)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anticarcinogenic Agents : CK(2152) : AC(1018), Antioxidants : CK(34551) : AC(14499), Apoptotic : CK(9585) : AC(7379), Chemotherapeutic : CK(4390) : AC(1635), MicroRNA modulator : CK(1560) : AC(897)

Phytochemicals inhibit the immunosuppressive functions of myeloid-derived suppressor cells.

Pubmed Data : Int Immunopharmacol. 2018 Aug ;61:231-240. Epub 2018 Jun 9. PMID: 29894862

Article Published Date : Jul 31, 2018

Authors : Antero Salminen, Kai Kaarniranta, Anu Kauppinen

Study Type : Review

Additional Links

Substances : Beta-glucan : CK(683) : AC(114), Curcumin : CK(7239) : AC(3319), Flavonoids : CK(4698) : AC(2176)

Diseases : Aging: Immunosenecence : CK(67) : AC(24), Alzheimer's Disease : CK(5355) : AC(2210), Cancers: All : CK(36404) : AC(14363), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360)

Piperine potentiates curcumin-mediated repression of mTORC1 signaling in human intestinal epithelial cells.

Pubmed Data : J Nutr Biochem. 2018 Apr 25 ;57:276-286. Epub 2018 Apr 25. PMID: 29800814

Article Published Date : Apr 24, 2018

Authors : Harleen Kaur, Bo He, Chenhua Zhang, Elliott Rodriguez, David S Hage, Régis Moreau

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Piperine : CK(600) : AC(258)

Diseases : Colorectal Cancer : CK(4889) : AC(2276), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Plants as source of new therapies for endometriosis: a review of preclinical and clinical studies.

Pubmed Data : Hum Reprod Update. 2021 Feb 19 ;27(2):367-392. PMID: 33124671

Article Published Date : Feb 18, 2021

Authors : Gabriela F Meresman, Martin Götte, Matthias W Laschke

Study Type : Review

Additional Links

Diseases : Endometriosis : CK(579) : AC(159)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antiproliferative : CK(10001) : AC(7491), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Vascular Endothelial Growth Factor Inhibitors : CK(611) : AC(335)

Polymerized nano-curcumin has significant effects on the EAE scores and myelin repair mechanisms in an animal model of multiple sclerosis.

Pubmed Data : Neuropharmacology. 2015 Dec ;99:156-67. Epub 2015 Jul 23. PMID: 26211978

Article Published Date : Nov 30, 2015

Authors : Maryam Mohajeri, Majid Sadeghizadeh, Farhood Najafi, Mohammad Javan

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Demyelinating Diseases : CK(3227) : AC(780), Multiple Sclerosis : CK(2432) : AC(557)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949), Remyelination : CK(24) : AC(13)

Additional Keywords : Gene Expression Regulation : CK(1401) : AC(623)

Polyphenol and methylsulfonylmethane supplementation improves immune, DAMP signaling, and inflammatory responses during recovery from all-out running efforts.

Pubmed Data : Front Physiol. 2021 ;12:712731. Epub 2021 Aug 31. PMID: 34531760

Article Published Date : Dec 31, 2020

Authors : Brian K McFarlin, David W Hill, Jakob L Vingren, John H Curtis, Elizabeth A Tanner

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), MSM (Methylsulfonylmethane) : CK(175) : AC(41), Polyphenols : CK(2736) : AC(1003), Pomegranate Polyphenols : CK(22) : AC(10)

Therapeutic Actions : Exercise: Running : CK(613) : AC(73)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Polyphenolic compounds could be beneficial in psychiatric disorders.

Pubmed Data : Oxid Med Cell Longev. 2015;2015:248529. Epub 2015 Jun 9. PMID: 26180581

Article Published Date : Dec 31, 2014

Authors : Jana Trebatická, Zdeňka Ďuračková

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Ginkgo biloba : CK(2047) : AC(658), Green Tea : CK(4491) : AC(1379), Oak : CK(113) : AC(50), Polyphenols : CK(2736) : AC(1003)

Diseases : Attention Deficit Disorder : CK(1294) : AC(167), Depression : CK(9574) : AC(1756), Oxidative Stress : CK(14758) : AC(5716), Psychiatric Disorders : CK(362) : AC(95), Schizophrenia : CK(1128) : AC(200)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Polyphenols and inflammatory bowel disease: Natural products with therapeutic effects?

Pubmed Data : Crit Rev Food Sci Nutr. 2022 Nov 8:1-24. Epub 2022 Nov 8. PMID: 36345891

Article Published Date : Nov 07, 2022

Authors : Mostafa Vaghari-Tabari, Forough Alemi, Maryam Zokaei, Soheila Moein, Durdi Qujeq, Bahman Yousefi, Payam Farzami, Seyed Soheil Hosseininasab

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), EGCG (Epigallocatechin gallate) : CK(1587) : AC(820), Naringenin : CK(704) : AC(394), Polyphenols : CK(2736) : AC(1003), Quercetin : CK(1876) : AC(855), Resveratrol : CK(3228) : AC(1513)

Diseases : Inflammatory Bowel Diseases : CK(3196) : AC(926)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Gastrointestinal Agents : CK(7657) : AC(2274)

Polyphenols can be promising in combating diabetic neuropathy-associated damaging pathways.

Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:9940169. Epub 2021 May 13. PMID: 34093722

Article Published Date : Dec 31, 2020

Authors : Md Tanvir Kabir, Nuzhat Tabassum, Md Sahab Uddin, Faissal Aziz, Tapan Behl, Bijo Mathew, Md Habibur Rahman, Raushanara Akter, Abdur Rauf, Lotfi Aleya

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Kaempferol : CK(354) : AC(229), Naringenin : CK(704) : AC(394), Polyphenols : CK(2736) : AC(1003), Quercetin : CK(1876) : AC(855), Resveratrol : CK(3228) : AC(1513)

Diseases : Diabetic Neuropathy : CK(455) : AC(113)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Renoprotective : CK(4544) : AC(1971)

Possible role of common spices as a preventive and therapeutic agent for Alzheimer's disease.

Pubmed Data : Int J Prev Med. 2017 ;8:5. Epub 2017 Feb 7. PMID: 28250905

Article Published Date : Dec 31, 2016

Authors : Omid Mirmosayyeb, Amirpouya Tanhaei, Hamid R Sohrabi, Ralph N Martins, Mana Tanhaei, Mohammad Amin Najafi, Ali Safaei, Rokhsareh Meamar

Study Type : Review

Additional Links

Substances : Cinnamon : CK(692) : AC(202), Culinary Herbs and Spices : CK(14909) : AC(4428), Ginger : CK(1593) : AC(479), Saffron : CK(1324) : AC(285), Turmeric : CK(9427) : AC(3904)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210), Dementia : CK(2211) : AC(386)

Pharmacological Actions : Acetylcholinesterase Inhibitor : CK(259) : AC(128), Anti-Inflammatory Agents : CK(39737) : AC(15858)

Post-injury curcumin administration may improve patient outcome by reducing acute activation of microglia/macrophages and neuronal apoptosis.

Pubmed Data : J Neuroinflammation. 2014 ;11:59. Epub 2014 Mar 27. PMID: 24669820

Article Published Date : Dec 31, 2013

Authors : Hai-tao Zhu, Chen Bian, Ji-chao Yuan, Wei-hua Chu, Xin Xiang, Fei Chen, Cheng-shi Wang, Hua Feng, Jiang-Kai Lin

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain Inflammation : CK(1784) : AC(928), Brain Injury: Traumatic : CK(383) : AC(131)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949)

Pre-clinical and clinical efficacy of curcumin as an anti-inflammatory agent for periodontitis.

Pubmed Data : Rev Cient Odontol (Lima). 2024 ;12(4):e222. Epub 2024 Nov 23. PMID: 39912085

Article Published Date : Dec 31, 2023

Authors : Fiki Muhammad Ridho, Andika Julyanto Syachputra, Anisa Dias Nur'aini, Kamailiya Ulfah, Muhamad Faqih, Andang Nurhuda

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Periodontitis : CK(1328) : AC(311)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-10 upregulation : CK(1296) : AC(436), Interleukin-4 upregulation : CK(182) : AC(70), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Prebiotic effect of berberine and curcumin Is associated with the improvement of obesity.

Pubmed Data : Nutrients. 2021 Apr 24 ;13(5). Epub 2021 Apr 24. PMID: 33923174

Article Published Date : Apr 23, 2021

Authors : Audrey M Neyrinck, Cándido Robles Sánchez, Julie Rodriguez, Patrice D Cani, Laure B Bindels, Nathalie M Delzenne

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(2483) : AC(1079), Curcumin : CK(7239) : AC(3319)

Diseases : Obesity : CK(11004) : AC(2672)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Gastrointestinal Agents : CK(7657) : AC(2274)

Additional Keywords : Anti-Obesity Agents : CK(5172) : AC(1320)

Promising roles of Zingiber officinale roscoe, Curcuma longa L., and Momordica charantia L. as immunity modulators against COVID-19.

Pubmed Data : J Agric Food Res. 2023 Dec ;14:100680. Epub 2023 Jun 12. PMID: 37346755

Article Published Date : Nov 30, 2023

Authors : Hassan I Sheikh, Nor Hafizah Zakaria, Fadzilah Adibah Abdul Majid, Fatihah Zamzuri, Anis Fadhlina, Muhammad Afnan Shakir Hairani

Study Type : Review

Additional Links

Substances : Bitter Melon : CK(411) : AC(166), Ginger : CK(1593) : AC(479), Turmeric : CK(9427) : AC(3904)

Diseases : Coronavirus Disease (Covid-19) : CK(1328) : AC(329)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Antiviral Agents : CK(3095) : AC(1702)

Protection of curcumin against streptozocin-induced pancreatic cell destruction in T2D rats.

Pubmed Data : Planta Med. 2020 Jan ;86(2):113-120. Epub 2019 Dec 4. PMID: 31801161

Article Published Date : Dec 31, 2019

Authors : Li Qihui, Deng Shuntian, Zhou Xin, Yu Xiaoxia, Chen Zhongpei

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Diabetes Mellitus: Type 2 : CK(12953) : AC(2579)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Pancreato Protective Agents : CK(554) : AC(299), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Protective effect of Curcuma longa L. leaves and pseudostems extract against 1-chloro-2,4-dinitrobenzene-induced atopic dermatitis.

Pubmed Data : J Ethnopharmacol. 2025 Feb 10 ;338(Pt 3):119138. Epub 2024 Nov 19. PMID: 39566860

Article Published Date : Feb 09, 2025

Authors : Arachchige Maheshika Kumari Jayasinghe, Kirinde Gedara Isuru Sandanuwan Kirindage, Sun-Hyung Kim, Seok Lee, Kyungsook Jung, Sun-Yup Shim, Ginnae Ahn

Study Type : Animal Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Atopic Dermatitis : CK(2139) : AC(366)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Protective effect of curcumin against cytomegalovirus infection in Balb/c mice.

Pubmed Data : Environ Toxicol Pharmacol. 2014 May ;37(3):1140-7. Epub 2014 Apr 21. PMID: 24802527

Article Published Date : Apr 30, 2014

Authors : Yali Lv, Ning Lei, Dan Wang, Zhuoling An, Guangrun Li, Feifei Han, He Liu, Lihong Liu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cytomegalovirus Infections : CK(133) : AC(52)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Antiviral Agents : CK(3095) : AC(1702), Interleukin-6 Downregulation : CK(9337) : AC(3613), Malondialdehyde Down-regulation : CK(3028) : AC(992), Superoxide Dismutase Up-regulation : CK(2383) : AC(928), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Protective effect of curcumin against microplastic and nanoplastics toxicity.

Pubmed Data : Int J Environ Health Res. 2024 Aug 19:1-40. Epub 2024 Aug 19. PMID: 39161080

Article Published Date : Aug 18, 2024

Authors : Habibeh Mashayekhi-Sardoo, Samaneh Sepahi, Adel Ghorani-Azam, Hedyeh Askarpour, Thomas P Johnston, Amirhossein Sahebkar

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Microplastic Toxicity : CK(1075) : AC(509)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Problem Substances : Nano Plastic-and Micro-Particles : CK(557) : AC(257)

Protective effect of pristine C60 fullerene nanoparticle in combination with curcumin against hyperglycemia-induced kidney damage in diabetes caused by streptozotocin

Pubmed Data : J Food Biochem. 2020 Nov ;44(11):e13470. Epub 2020 Sep 11. PMID: 32914898

Article Published Date : Oct 31, 2020

Authors : Ersin Demir, Abdullah Aslan

Study Type : Animal Study

Additional Links

Substances : Carbon 60 : CK(79) : AC(48), Curcumin : CK(7239) : AC(3319)

Diseases : Diabetic Nephropathy : CK(1405) : AC(539), Hyperglycemia : CK(2240) : AC(709), Kidney Damage : CK(805) : AC(359)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Renoprotective : CK(4544) : AC(1971)

Protective effect of the association of curcumin with piperine on prostatic lesions.

Pubmed Data : Food Chem Toxicol. 2021 Dec ;158:112700. Epub 2021 Nov 25. PMID: 34838672

Article Published Date : Nov 30, 2021

Authors : Camila Helena Facina, Silvana Gisele Pegorin Campos, Thalles Fernando Rocha Ruiz, Rejane Maira Góes, Patrícia Simone Leite Vilamaior, Sebastião Roberto Taboga

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Piperine : CK(600) : AC(258)

Diseases : Bisphenol Toxicity : CK(4416) : AC(1329), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Problem Substances : Bisphenol A : CK(4570) : AC(1323)

Protective effects of curcumin against traumatic brain injury.

Pubmed Data : Biomed Pharmacother. 2022 Oct ;154:113621. Epub 2022 Aug 30. PMID: 36055110

Article Published Date : Sep 30, 2022

Authors : Danial Khayatan, Seyed Mehrad Razavi, Zahra Najafi Arab, Amir Hossein Niknejad, Kiana Nouri, Saeideh Momtaz, Eric Gumpricht, Tannaz Jamialahmadi, Amir Hossein Abdolghaffari, George E Barreto, Amirhossein Sahebkar

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain Injury: Traumatic : CK(383) : AC(131)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Protective effects of curcumin and Ginkgo biloba extract combination on a new model of Alzheimer's disease.

Pubmed Data : Inflammopharmacology. 2023 Mar 1. Epub 2023 Mar 1. PMID: 36856916

Article Published Date : Feb 28, 2023

Authors : Abdel-Azim Assi, Magda M Y Farrag, Dalia M Badary, Essmat A H Allam, Mariam A Nicola

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Ginkgo biloba : CK(2047) : AC(658)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Neuroprotective Agents : CK(20061) : AC(7949), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Protective effects of curcumin on ischemia/reperfusion injury.

Pubmed Data : Phytother Res. 2022 Sep 19. Epub 2022 Sep 19. PMID: 36123613

Article Published Date : Sep 18, 2022

Authors : Malihe Mohamadian, Negin Parsamanesh, Hossein Chiti, Thozhukat Sathyapalan, Amirhossein Sahebkar

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Ischemia : CK(626) : AC(325)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Protective effects of maternal administration of curcumin and hesperidin in the rat offspring following repeated febrile seizure.

Pubmed Data : Int Immunopharmacol. 2020 Jun 22 ;86:106720. Epub 2020 Jun 22. PMID: 32585605

Article Published Date : Jun 21, 2020

Authors : Rabi Atabaki, Ali Roohbakhsh, Ali Moghimi, Soghra Mehri

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Hesperidin : CK(953) : AC(360)

Diseases : Brain Inflammation : CK(1784) : AC(928), Epilepsy : CK(1199) : AC(327)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Malondialdehyde Down-regulation : CK(3028) : AC(992), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Puffing is a promising and simple method for enhancing the antioxidant and anti-inflammatory properties of turmeric.

Pubmed Data : Antioxidants (Basel). 2019 Oct 23 ;8(11). Epub 2019 Oct 23. PMID: 31652746

Article Published Date : Oct 22, 2019

Authors : Yohan Choi, Insu Ban, Hyungjae Lee, Moo-Yeol Baik, Wooki Kim

Study Type : In Vitro Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Pulmonary delivery of curcumin-loaded glycyrrhizic acid nanoparticles for anti-inflammatory therapy.

Pubmed Data : Biomater Sci. 2022 Oct 20. Epub 2022 Oct 20. PMID: 36263591

Article Published Date : Oct 19, 2022

Authors : Chunxian Piao, Chuanyu Zhuang, Minji Kang, Jihun Oh, Minhyung Lee

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Glycyrrhizin : CK(251) : AC(102)

Diseases : Lung Injury: Acute : CK(533) : AC(253)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Quality of evidence supporting the role of Curcuma Longa extract/curcumin for the treatment of osteoarthritis.

Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:6159874. Epub 2022 Mar 31. PMID: 35399636

Article Published Date : Dec 31, 2021

Authors : Wenqiang Chen, Hongshuo Shi, Pin Deng, Zhenguo Yang, Wenbin Liu, Lu Qi, Chengda Dong, Guomin Si, Dong Guo, Lei Wang

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Substances : Apigenin : CK(681) : AC(392), Caffeic acid phenethyl ester : CK(284) : AC(172), Curcumin : CK(7239) : AC(3319), EGCG (Epigallocatechin gallate) : CK(1587) : AC(820), Epicatechin : CK(67) : AC(36), Gallic Acid : CK(341) : AC(212), Polyphenols : CK(2736) : AC(1003), Quercetin : CK(1876) : AC(855), Resveratrol : CK(3228) : AC(1513), Rutin : CK(463) : AC(223), Silibinin : CK(460) : AC(231)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Radioprotective role of natural polyphenols: from sources to mechanisms.

Pubmed Data : Anticancer Agents Med Chem. 2021 Apr 18. Epub 2021 Apr 18. PMID: 33874875

Article Published Date : Apr 17, 2021

Authors : Muhammad Adnan, Azhar Rasul, Muhammad A Shah, Ghulam Hussain, Muhammad Asrar, Ammara Riaza, Iqra Sarfraza, Arif Hussaina, Khatereh Khorsandid, Ngit S Laie, Syed M Hussaina

Study Type : Animal Study

Additional Links

Diseases : Silibinin : CK(460) : AC(231)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Radioprotective : CK(2398) : AC(713)

Recent advances in the management of knee osteoarthritis.

Pubmed Data : Front Med (Lausanne). 2025 ;12:1523027. Epub 2025 Jan 21. PMID: 39906596

Article Published Date : Dec 31, 2024

Authors : Viktor Shtroblia, Pavlo Petakh, Iryna Kamyshna, Iryna Halabitska, Oleksandr Kamyshnyi

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Osteoarthritis: Knee : CK(2345) : AC(276)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trial.

Pubmed Data : J Nutr Biochem. 2014 Feb ;25(2):144-50. Epub 2013 Nov 6. PMID: 24445038

Article Published Date : Jan 31, 2014

Authors : Somlak Chuengsamarn, Suthee Rattanamongkolgul, Benjaluck Phonrat, Rungsunn Tungtrongchitr, Siwanon Jirawatnotai

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)

Diseases : Abdominal Obesity (Midsection Fat) : CK(480) : AC(68), C-Reactive Protein: Diabetes-Associated : CK(20) : AC(2), C-Reactive Protein: Diabetes-Associated : CK(20) : AC(2), Diabetes: Cardiovascular Illness : CK(744) : AC(133), Diabetes Mellitus: Type 2: Prevention : CK(1130) : AC(157), HDL: Low : CK(305) : AC(50), Inflammation : CK(16108) : AC(5498), Insulin Resistance : CK(4864) : AC(1098), Obesity : CK(11004) : AC(2672), Obesity: Abdominal : CK(480) : AC(68)

Pharmacological Actions : Anti-atherogenic : CK(482) : AC(162), Anti-Inflammatory Agents : CK(39737) : AC(15858)

Reductive metabolites of curcumin and their therapeutic effects.

Pubmed Data : Heliyon. 2020 Nov ;6(11):e05469. Epub 2020 Nov 12. PMID: 33241148

Article Published Date : Oct 31, 2020

Authors : Achyut Pandey, Maya Chaturvedi, Shruti Mishra, Pramod Kumar, Pallavi Somvanshi, Rupesh Chaturvedi

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cancers: All : CK(36404) : AC(14363), Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Chemotherapeutic : CK(4390) : AC(1635), Immunomodulatory : CK(6531) : AC(2360)

Resveratrol and curcumin reduce inflammation associated with acute small intestinal inflammation.

Pubmed Data : PLoS One. 2010;5(12):e15099. Epub 2010 Dec 3. PMID: 21151942

Article Published Date : Jan 01, 2010

Authors : Stefan Bereswill, Melba Muñoz, André Fischer, Rita Plickert, Lea-Maxie Haag, Bettina Otto, Anja A Kühl, Christoph Loddenkemper, Ulf B Göbel, Markus M Heimesaat

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Resveratrol : CK(3228) : AC(1513)

Diseases : Gastrointestinal Inflammation : CK(330) : AC(157), Inflammatory Bowel Diseases : CK(3196) : AC(926)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Review of the effects and mechanism of curcumin in the treatment of inflammatory bowel disease.

Pubmed Data : Front Pharmacol. 2022 ;13:908077. Epub 2022 Jun 20. PMID: 35795556

Article Published Date : Dec 31, 2021

Authors : Yuan Lin, Hengjian Liu, Lingling Bu, Chen Chen, Xiaofeng Ye

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Inflammatory Bowel Diseases : CK(3196) : AC(926)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Gastrointestinal Agents : CK(7657) : AC(2274)

Review: Curcumin has therapeutic potential in multiple sclerosis.

Pubmed Data : Int Immunopharmacol. 2011 Mar;11(3):323-30. Epub 2010 Sep 8. PMID: 20828641

Article Published Date : Mar 01, 2011

Authors : Lin Xie, Xiao-Kang Li, Shiro Takahara

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Inflammation : CK(16108) : AC(5498), Multiple Sclerosis : CK(2432) : AC(557)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Rice bran arabinoxylan and curcumin therapy may be of benefit to patients with early-stage B-cell lymphoid malignancies.

Pubmed Data : Integr Cancer Ther. 2016 Jun ;15(2):183-9. Epub 2016 May 6. PMID: 27154182

Article Published Date : May 31, 2016

Authors : Terry Golombick, Terrence H Diamond, Arumugam Manoharan, Rajeev Ramakrishna

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Rice Bran : CK(346) : AC(101)

Diseases : Leukemia: B-Cell : CK(16) : AC(6), Leukemia: Chronic Lymphocytic Leukemia (CLL) : CK(161) : AC(54), Smoldering multiple myeloma (SMM) : CK(22) : AC(3)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Role of natural products in alleviation of rheumatoid arthritis.

Pubmed Data : J Food Biochem. 2021 Apr ;45(4):e13673. Epub 2021 Feb 24. PMID: 33624882

Article Published Date : Mar 31, 2021

Authors : Dhvani Sharma, Pramila Chaubey, Vasanti Suvarna

Study Type : Review

Additional Links

Substances : Carotenoids : CK(4462) : AC(1222), Flavonoids : CK(4698) : AC(2176), Ginger : CK(1593) : AC(479), Turmeric : CK(9427) : AC(3904)

Diseases : Rheumatoid Arthritis : CK(2322) : AC(562)

Therapeutic Actions : Dietary Modification: Mediterranean Diet : CK(1804) : AC(216), Dietary Modification: Vegan Diet : CK(125) : AC(16)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Role of Polyphenols in alleviating Alzheimer's disease: A Review

Pubmed Data : Curr Med Chem. 2022 Dec 2. Epub 2022 Dec 2. PMID: 36476438

Article Published Date : Dec 01, 2022

Authors : Tharsius Raja William Raja, Veeramuthu Duraipandiyan, Savarimuthu Ignacimuthu, Udaiyappan Janakiraman, Soosaimanickam Maria Packiam

Study Type : Review

Additional Links

Substances : Catechin : CK(965) : AC(313), Curcumin : CK(7239) : AC(3319), Hesperidin : CK(953) : AC(360), Kaempferol : CK(354) : AC(229), Polyphenols : CK(2736) : AC(1003), Quercetin : CK(1876) : AC(855), Resveratrol : CK(3228) : AC(1513)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Safety and efficacy of moderately-high dose Turmacin® (Turmerosaccharide >10% w/w) supplementation on joint discomfort.

Pubmed Data : J Diet Suppl. 2024 ;21(1):28-37. Epub 2023 Feb 14. PMID: 36786714

Article Published Date : Dec 31, 2023

Authors : Jeffrey Pradeep Raj, Shreeraam Venkatachalam, Rajkumar S Amaravati

Study Type : Human Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Arthritis : CK(5826) : AC(1505)

Pharmacological Actions : Analgesics : CK(9680) : AC(1472), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antinoceceptive : CK(959) : AC(291)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Short term curcumin intervention ablates diabetic kidney disease progress with activating Nrf2 anti-oxidative system and anti-inflammatory efficacies in patients with T2DM.

Pubmed Data : Exp Clin Endocrinol Diabetes. 2015 Jun ;123(6):360-7. Epub 2015 Apr 14. PMID: 25875220

Article Published Date : May 31, 2015

Authors : H Yang, W Xu, Z Zhou, J Liu, X Li, L Chen, J Weng, Z Yu

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Diabetes Mellitus: Type 2 : CK(12953) : AC(2579), Diabetic Nephropathy : CK(1405) : AC(539)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Malondialdehyde Down-regulation : CK(3028) : AC(992), Nrf2 activation : CK(3156) : AC(1794)

Additional Keywords : Significant Treatment Outcome : CK(4297) : AC(505)

Short term effect of tetrahydrocurcumin on adipose angiogenesis in very high-fat diet-induced obesity mouse model.

Pubmed Data : Front Nutr. 2023 ;10:1221935. Epub 2023 Oct 9. PMID: 37876615

Article Published Date : Dec 31, 2022

Authors : Bhornprom Yoysungnoen, Umarat Srisawat, Pritsana Piyabhan, Naphatsanan Duansak, Nattapon Sookprasert, Nakorn Mathuradavong, Natwadee Poomipark, Narongsuk Munkong, Pholawat Tingpej, Chatchawan Changtam

Study Type : Animal Study

Additional Links

Substances : Tetrahydrocurcumin : CK(173) : AC(99)

Diseases : High Fat Diet : CK(2040) : AC(984), Obesity : CK(11004) : AC(2672)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(944) : AC(588), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(1141) : AC(720), Vascular Endothelial Growth Factor Inhibitors : CK(611) : AC(335)

Short term supplementation with curcuminoid and piperine combination significantly improves oxidative and inflammatory status in patients with MetS.

Pubmed Data : Clin Nutr. 2015 Jan 7. Epub 2015 Jan 7. PMID: 25618800

Article Published Date : Jan 06, 2015

Authors : Yunes Panahi, Mahboobeh Sadat Hosseini, Nahid Khalili, Effat Naimi, Muhammed Majeed, Amirhossein Sahebkar

Study Type : Human Study

Additional Links

Substances : Curcuminoids : CK(7851) : AC(3498), Piperine : CK(600) : AC(258)

Diseases : Metabolic Diseases : CK(1273) : AC(272), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Additional Keywords : Significant Treatment Outcome : CK(4297) : AC(505)

Short-term adjunctive therapy with curcuminoids can suppress systemic inflammation in patients suffering from SM-induced chronic pulmonary complications.

Pubmed Data : Drug Res (Stuttg). 2014 Sep 30. Epub 2014 Sep 30. PMID: 25268878

Article Published Date : Sep 29, 2014

Authors : Y Panahi, M Ghanei, S Bashiri, A Hajihashemi, A Sahebkar

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Chemical Weapon Agent Injury : CK(26) : AC(6), Chemical Weapon Agent Injury: Sulfur Mustard : CK(62) : AC(8)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Short-term supplementation with curcumin improves liver fat and transaminase levels in patients with NAFLD.

Pubmed Data : Drug Res (Stuttg). 2017 Apr ;67(4):244-251. Epub 2017 Feb 3. PMID: 28158893

Article Published Date : Mar 31, 2017

Authors : Yunes Panahi, Parisa Kianpour, Reza Mohtashami, Ramezan Jafari, Luis E Simental-Mendía, Amirhossein Sahebkar

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Polyphenols : CK(2736) : AC(1003)

Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Stem cell therapy: curcumin does the trick.

Pubmed Data : Phytother Res. 2019 Nov ;33(11):2927-2937. Epub 2019 Aug 26. PMID: 31452263

Article Published Date : Oct 31, 2019

Authors : Simin Sharifi, Sepideh Zununi Vahed, Elham Ahmadian, Solmaz Maleki Dizaj, Atefeh Abedi, Seyed Mahdi Hosseiniyan Khatibi, Mohammad Samiei

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Structural optimization of naturally derived Ar-turmerone, as novel neuroinflammation suppressors effective in an Alzheimer mouse model.

Pubmed Data : Bioorg Med Chem. 2025 Jan 1 ;117:118014. Epub 2024 Nov 22. PMID: 39602866

Article Published Date : Dec 31, 2024

Authors : Wei Zhou, Yuanyuan Chang, Qingwei Xiao, Zhujie Deng, Lanyue Zhang, Zhengqiang Yuan, Zhiyun Du

Study Type : Animal Study

Additional Links

Substances : Turmerones : CK(32) : AC(23)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210), Brain Inflammation : CK(1784) : AC(928), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Neuroprotective Agents : CK(20061) : AC(7949), Nitric Oxide Inhibitor : CK(705) : AC(356), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Sulforaphane could be a potential treatment for doxorubicin-associated inflammation.

Pubmed Data : Sci Rep. 2021 Jan 12 ;11(1):545. Epub 2021 Jan 12. PMID: 33436962

Article Published Date : Jan 11, 2021

Authors : Haidy A Saleh, Eman Ramdan, Mohey M Elmazar, Hassan M E Azzazy, Anwar Abdelnaser

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Resveratrol : CK(3228) : AC(1513), Sulforaphane : CK(1344) : AC(630)

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(845) : AC(423), Inflammation : CK(16108) : AC(5498), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Chemoprotective Agents : CK(4278) : AC(1621), Immunomodulatory : CK(6531) : AC(2360), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Supplementation with tetrahydrocurcumin enhances the therapeutic effects of dexamethasone in a murine model of allergic asthma.

Pubmed Data : Int Arch Allergy Immunol. 2020 ;181(11):822-830. Epub 2020 Aug 12. PMID: 32784298

Article Published Date : Dec 31, 2019

Authors : Yin Fan Wu, Yan Qiu Chen, Qin Li, Xiao Yan Ye, Xiao Zuo, Yi Lin Shi, Xing Yue Guo, Lin Xu, Lin Sun, Chun Wei Li, Yan Yang

Study Type : Animal Study

Additional Links

Substances : Tetrahydrocurcumin : CK(173) : AC(99)

Diseases : Asthma : CK(3242) : AC(707)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-17 downregulation : CK(502) : AC(192), Interleukin-4 downregulation : CK(460) : AC(173), Interleukin-5 downregulation : CK(154) : AC(65)

Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

Suppressive effect of curcumin on apoptosis of articular chondrocytes.

Pubmed Data : Cytotechnology. 2025 Apr ;77(2):52. Epub 2025 Jan 31. PMID: 39897107

Article Published Date : Mar 31, 2025

Authors : Haobo Li, Shuai Yuan, Zhipeng Yue, Lei Zhang, Shu Chen, Qirong Qian, Qiwei Fu, Yi Chen

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Chondroprotective : CK(226) : AC(116), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Synergistic anti-inflammatory activity of apigenin and curcumin co-encapsulated in caseins assessed with lipopolysaccharide-stimulated RAW 264.7 macrophages.

Pubmed Data : Int J Biol Macromol. 2021 Oct 27 ;193(Pt A):702-712. Epub 2021 Oct 27. PMID: 34717976

Article Published Date : Oct 26, 2021

Authors : Shan Hong, Vermont P Dia, Qixin Zhong

Study Type : In Vitro Study

Additional Links

Substances : Apigenin : CK(681) : AC(392), Curcumin : CK(7239) : AC(3319)

Diseases : Inflammation : CK(16108) : AC(5498), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

Synergistic anti-inflammatory activity of ginger and turmeric extracts.

Pubmed Data : Molecules. 2022 Jun 16 ;27(12). Epub 2022 Jun 16. PMID: 35745000

Article Published Date : Jun 15, 2022

Authors : Xian Zhou, Sualiha Afzal, Hans Wohlmuth, Gerald Münch, David Leach, Mitchell Low, Chun Guang Li

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Ginger : CK(1593) : AC(479)

Diseases : Inflammation : CK(16108) : AC(5498), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669), Plant Extracts : CK(18762) : AC(6782)

Synergistic berberine chloride and curcumin-loaded nanofiber therapies against Methicillin-Resistant Staphylococcus aureus infection.

Pubmed Data : Int Immunopharmacol. 2024 Aug 8 ;140:112856. Epub 2024 Aug 8. PMID: 39121609

Article Published Date : Aug 07, 2024

Authors : Karthikeyan Kandaswamy, Siva Prasad Panda, Raghunandhakumar Subramanian, Haroon Khan, Mohammed Rafi Shaik, Shaik Althaf Hussain, Ajay Guru, Jesu Arockiaraj

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(2483) : AC(1079), Curcumin : CK(7239) : AC(3319)

Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA) : CK(477) : AC(261)

Pharmacological Actions : Anti-Bacterial Agents : CK(4228) : AC(1989), Anti-Inflammatory Agents : CK(39737) : AC(15858)

Targeted immunomodulation of inflammatory monocytes across the blood-brain barrier by curcumin.

Pubmed Data : Biomaterials. 2020 Jul ;245:119987. Epub 2020 Mar 19. PMID: 32229332

Article Published Date : Jun 30, 2020

Authors : Lisen Lu, Shuhong Qi, Yuzhou Chen, Haiming Luo, Songlin Huang, Xiang Yu, Qingming Luo, Zhihong Zhang

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Multiple Sclerosis : CK(2432) : AC(557)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Additional Keywords : Blood Brain Barrier : CK(240) : AC(88)

Targeting inflammation through diet in patients after spinal cord injury could help with depressive symptoms.

Pubmed Data : J Neuroinflammation. 2015 ;12(1):204. Epub 2015 Nov 6. PMID: 26545369

Article Published Date : Dec 31, 2014

Authors : David J Allison, David S Ditor

Study Type : Human Study

Additional Links

Substances : Chlorella (Algae) : CK(526) : AC(139), Coenzyme Q10 : CK(2359) : AC(412), Curcumin : CK(7239) : AC(3319), DHA (Docosahexaenoic Acid) : CK(1285) : AC(244), EPA (Eicosapentaenoic Acid) : CK(1047) : AC(154), Selenium : CK(1753) : AC(393), Vitamin E : CK(3040) : AC(571)

Diseases : Depression : CK(9574) : AC(1756), Spinal Cord Inflammation : CK(14) : AC(3), Spinal Cord Injuries : CK(890) : AC(347)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antidepressive Agents : CK(7908) : AC(1466)

Additional Keywords : Dietary Modification : CK(388) : AC(59), Diseases that are Linked : CK(2345) : AC(305), Supplementation : CK(413) : AC(60)

Targeting NF-κB signalling by calebin A in the multicellular tumor microenvironment.

Pubmed Data : Biomedicines. 2020 Jul 22 ;8(8). Epub 2020 Jul 22. PMID: 32708030

Article Published Date : Jul 21, 2020

Authors : Constanze Buhrmann, Parviz Shayan, Kishore Banik, Ajaikumar B Kunnumakkara, Peter Kubatka, Lenka Koklesova, Mehdi Shakibaei

Study Type : In Vitro Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Colorectal Cancer : CK(4889) : AC(2276)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Apoptotic : CK(9585) : AC(7379), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Additional Keywords : Tumor Microenvironment : CK(170) : AC(121)

Targeting oxidative stress involved in endometriosis and its pain.

Pubmed Data : Biomolecules. 2022 Jul 29 ;12(8). Epub 2022 Jul 29. PMID: 36008949

Article Published Date : Jul 28, 2022

Authors : Lauren Clower, Taylor Fleshman, Werner J Geldenhuys, Nalini Santanam

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Melatonin : CK(2891) : AC(911), NAC (N-acetyl-L-cysteine) : CK(1429) : AC(366), Vitamin C : CK(6066) : AC(1408)

Diseases : Endometriosis : CK(579) : AC(159), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Angiogenesis Inhibitors : CK(724) : AC(481), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Antiproliferative : CK(10001) : AC(7491)

Tetrahydrocurcumin ameliorates skin inflammation by modulating autophagy in high-fat diet-induced obesity.

Pubmed Data : Biomed Res Int. 2021 ;2021:6621027. Epub 2021 Jun 14. PMID: 34222477

Article Published Date : Dec 31, 2020

Authors : Jung Eun Kim, Hye Ran Kim, Jin Cheol Kim, Eun Soo Lee, Choon Hee Chung, Eun Young Lee, Bo Young Chung

Study Type : Animal Study

Additional Links

Substances : Tetrahydrocurcumin : CK(173) : AC(99)

Diseases : High Fat Diet : CK(2040) : AC(984), Inflammation : CK(16108) : AC(5498), Obesity : CK(11004) : AC(2672)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Tetrahydrocurcumin and Octahydrocurcumin possess superior anti-inflammatory effects in vivo.

Pubmed Data : Front Pharmacol. 2018 ;9:1181. Epub 2018 Oct 17. PMID: 30386242

Article Published Date : Dec 31, 2017

Authors : Zhen-Biao Zhang, Dan-Dan Luo, Jian-Hui Xie, Yan-Fang Xian, Zheng-Quan Lai, Yu-Hong Liu, Wei-Hai Liu, Jian-Nan Chen, Xiao-Ping Lai, Zhi-Xiu Lin, Zi-Ren Su

Study Type : Animal Study

Additional Links

Substances : Tetrahydrocurcumin : CK(173) : AC(99)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Tetrahydrocurcumin can be a promising candidate for the prevention of chemotherapy induced peripheral neuropathy.

Pubmed Data : Chem Biol Interact. 2015 Jun 20 ;238:118-128. Epub 2015 Jun 20. PMID: 26102012

Article Published Date : Jun 19, 2015

Authors : N Greeshma, K G Prasanth, Bhaskar Balaji

Study Type : Animal Study

Additional Links

Substances : Tetrahydrocurcumin : CK(173) : AC(99)

Diseases : Chemotherapy-Induced Toxicity: Vincristine : CK(13) : AC(7), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antinoceceptive : CK(959) : AC(291), Antioxidants : CK(34551) : AC(14499), Chemoprotective Agents : CK(4278) : AC(1621), Neuroprotective Agents : CK(20061) : AC(7949), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Tetrahydrocurcumin improves lipopolysaccharide-induced myocardial dysfunction.

Pubmed Data : Phytomedicine. 2022 Sep ;104:154283. Epub 2022 Jun 18. PMID: 35779282

Article Published Date : Aug 31, 2022

Authors : Hanzhao Zhu, Liyun Zhang, Hao Jia, Lu Xu, Yu Cao, Mengen Zhai, Kaifeng Li, Lin Xia, Liqing Jiang, Xiang Li, Yenong Zhou, Jincheng Liu, Shiqiang Yu, Weixun Duan

Study Type : Animal Study

Additional Links

Substances : Tetrahydrocurcumin : CK(173) : AC(99)

Diseases : Inflammation : CK(16108) : AC(5498), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963)

Tetrahydrocurcumin lipid nanoparticle based gel promotes penetration into deeper skin layers and alleviates atopic dermatitis.

Pubmed Data : Nanomaterials (Basel). 2022 Feb 14 ;12(4). Epub 2022 Feb 14. PMID: 35214966

Article Published Date : Feb 13, 2022

Authors : Komal Saini, Nancy Modgill, Kamalinder K Singh, Vandita Kakkar

Study Type : Animal Study

Additional Links

Substances : Tetrahydrocurcumin : CK(173) : AC(99)

Diseases : Atopic Dermatitis : CK(2139) : AC(366)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Tetrahydrocurcumin mitigates acute hypobaric hypoxia-induced cerebral oedema and inflammation.

Pubmed Data : Phytother Res. 2020 Jun 23. Epub 2020 Jun 23. PMID: 32573860

Article Published Date : Jun 22, 2020

Authors : Yang Pan, Yan Zhang, Jiani Yuan, Xuexinyu Ma, Yani Zhao, Yao Li, Fei Li, Xiaoli Gong, Junning Zhao, Haifeng Tang, Jianbo Wang

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Tetrahydrocurcumin : CK(173) : AC(99)

Diseases : Altitude Sickness : CK(57) : AC(17), Brain Inflammation : CK(1784) : AC(928), Hypoxia: Brain : CK(27) : AC(16)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949)

Tetrahydrocurcumin protected against nerve injury after traumatic brain injury.

Pubmed Data : Mol Neurobiol. 2024 Sep ;61(9):7026-7036. Epub 2024 Feb 17. PMID: 38368289

Article Published Date : Aug 31, 2024

Authors : Jie Zhang, Yue Gu, Wenxue Sun, Lisha Yu, Tushuai Li

Study Type : Animal Study

Additional Links

Substances : Tetrahydrocurcumin : CK(173) : AC(99)

Diseases : Traumatic Brain Injury : CK(537) : AC(153)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949)

Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response.

Pubmed Data : Exp Ther Med. 2019 Nov ;18(5):3681-3687. Epub 2019 Sep 5. PMID: 31602247

Article Published Date : Oct 31, 2019

Authors : Jiancheng Xi, Xiaobo Luo, Yipeng Wang, Jinglong Li, Lixin Guo, Guangseng Wu, Qingui Li

Study Type : Animal Study

Additional Links

Substances : Tetrahydrocurcumin : CK(173) : AC(99)

Diseases : Spinal Cord Injuries : CK(890) : AC(347)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Matrix Metalloproteinase-13 (MMP-13) Inhibitor : CK(229) : AC(104), Matrix metalloproteinase-3 (MMP-3) inhibitor : CK(238) : AC(107)

The administration of curcumin effectively ameliorates ovalbumin-induced airway inflammation in cough-variant asthma.

Pubmed Data : Discov Med. 2024 Oct ;36(189):2055-2062. PMID: 39463225

Article Published Date : Sep 30, 2024

Authors : Hui Yang, Jing Xie, Mengqing Wang, Xian Tang, Hua Wang, Kuan Rong

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Asthma : CK(3242) : AC(707), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

The anti-inflammatory potential of topical curcumin was similar to chlorhexidine-metronidazole but superior to chlorhexidine in affecting IL-1β and CCL28 levels.

Pubmed Data : Aust Dent J. 2015 Jul 29. Epub 2015 Jul 29. PMID: 26219195

Article Published Date : Jul 28, 2015

Authors : S J Pulikkotil, S Nath

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Gingivitis : CK(628) : AC(90), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Natural Substances Versus Drugs : CK(2806) : AC(560), Superiority of Natural Substances versus Drugs : CK(1875) : AC(394)

The antimalarial effect of curcumin is mediated by the inhibition of glycogen synthase kinase-3β.

Pubmed Data : J Med Food. 2017 Feb ;20(2):152-161. PMID: 28146408

Article Published Date : Jan 31, 2017

Authors : Amatul Hamizah Ali, Suhaini Sudi, Rusliza Basir, Noor Embi, Hasidah Mohd Sidek

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Malaria : CK(303) : AC(135)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interferon Gamma Reducer : CK(569) : AC(215), Interleukin-10 upregulation : CK(1296) : AC(436), Interleukin-4 upregulation : CK(182) : AC(70), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

The beneficial effects of curcumin on aging and age-related diseases.

Pubmed Data : Front Aging Neurosci. 2025 ;17:1533963. Epub 2025 Jan 20. PMID: 39906716

Article Published Date : Dec 31, 2024

Authors : Ying He, Yongqing Liu, Min Zhang

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Aging : CK(6221) : AC(1510)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), NF-kappaB Inhibitor : CK(5952) : AC(3464)

The benefit of combining curcumin, bromelain and harpagophytum to reduce inflammation in osteoarthritic synovial cells.

Pubmed Data : BMC Complement Med Ther. 2021 Oct 14 ;21(1):261. Epub 2021 Oct 14. PMID: 34649531

Article Published Date : Oct 13, 2021

Authors : Sybille Brochard, Julien Pontin, Benoit Bernay, Karim Boumediene, Thierry Conrozier, Catherine Baugé

Study Type : In Vitro Study

Additional Links

Substances : Bromelain : CK(375) : AC(120), Curcumin : CK(7239) : AC(3319)

Diseases : Inflammation : CK(16108) : AC(5498), Osteoarthritis : CK(2225) : AC(627)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

The combination of curcumin and berberine exhibited better ameliorative effects in treating NAFLD than lovastatin.

Pubmed Data : Biomed Pharmacother. 2018 Jan 17 ;99:325-333. Epub 2018 Jan 17. PMID: 29353208

Article Published Date : Jan 16, 2018

Authors : Wu-Wen Feng, Shuang-Yu Kuang, Can Tu, Zhi-Jie Ma, Jing-Yao Pang, Yan-Hui Wang, Qing-Ce Zang, Ta-Si Liu, Yan-Ling Zhao, Xiao-He Xiao, Jia-Bo Wang

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(2483) : AC(1079), Curcumin : CK(7239) : AC(3319)

Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Additional Keywords : Superiority of Natural Substances versus Drugs : CK(1875) : AC(394)

The combination of curcumin with LED blue light united red light irradiation can attain a higher efficiency of regulating proliferation and apoptosis in skin keratinocytes.

Pubmed Data : PLoS One. 2015;10(9):e0138754. Epub 2015 Sep 18. PMID: 26382065

Article Published Date : Dec 31, 2014

Authors : Tianhui Niu, Yan Tian, Qing Cai, Qu Ren, Lizhao Wei

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Inflammation : CK(16108) : AC(5498), Psoriasis : CK(922) : AC(255)

Therapeutic Actions : Light-Emitting Diodes (LEDs) Therapy : CK(326) : AC(87)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antiproliferative : CK(10001) : AC(7491)

The combined use of photobiomodulation and curcumin-loaded iron oxide nanoparticles significantly improved wound healing in diabetic rats.

Pubmed Data : Lasers Med Sci. 2022 Dec ;37(9):3601-3611. Epub 2022 Sep 2. PMID: 36053389

Article Published Date : Nov 30, 2022

Authors : Ahmadreza Ardeshirzadeh, Houssein Ahmadi, Mansooreh Mirzaei, Hamidreza Omidi, Atarodalsadat Mostafavinia, Abdollah Amini, Sahar Bayat, Mohammadjavad Fridoni, Sufan Chien, Mohammad Bayat

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Diabetes Mellitus: Type 1 : CK(2032) : AC(611), Wound Healing : CK(4555) : AC(1412)

Therapeutic Actions : Photobiomodulation : CK(17459) : AC(3331)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

The curcuminoids from C. longa exhibit actions at different locations in the pathogenesis of osteoarthritis.

Pubmed Data : Pharmacogn Rev. 2017 Jan-Jun;11(21):8-12. PMID: 28503046

Article Published Date : Dec 31, 2016

Authors : Marina Cristina Akuri, Sandra Maria Barbalho, Raíssa Meira Val, Elen Landgraf Guiguer

Study Type : Review

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Interleukin-8 downregulation : CK(1107) : AC(402), Lipoxygenase Inhibitors : CK(50) : AC(27)

The current review provides an updated overview of the metabolism and mechanism of action of curcumin in various organ pathophysiologies.

Pubmed Data : Food Chem Toxicol. 2015 Jun 9 ;83:111-124. Epub 2015 Jun 9. PMID: 26066364

Article Published Date : Jun 08, 2015

Authors : Shatadal Ghosh, Sharmistha Banerjee, Parames C Sil

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Diabetes Mellitus: Type 2 : CK(12953) : AC(2579), Inflammation : CK(16108) : AC(5498), Neurodegenerative Diseases : CK(13103) : AC(4279), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

The current study summarizes the reported knowledge on therapeutic potential of curcumin against multiple sclerosis.

Pubmed Data : Neurol Sci. 2017 Oct 27. Epub 2017 Oct 27. PMID: 29079885

Article Published Date : Oct 26, 2017

Authors : Munibah Qureshi, Ebtesam A Al-Suhaimi, Fazli Wahid, Omer Shehzad, Adeeb Shehzad

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Multiple Sclerosis : CK(2432) : AC(557)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

The dual role of curcumin and ferulic acid in counteracting chemoresistance and cisplatin-induced ototoxicity.

Pubmed Data : Sci Rep. 2020 Jan 23 ;10(1):1063. Epub 2020 Jan 23. PMID: 31974389

Article Published Date : Jan 22, 2020

Authors : Fabiola Paciello, Anna Rita Fetoni, Daniele Mezzogori, Rolando Rolesi, Antonella Di Pino, Gaetano Paludetti, Claudio Grassi, Diana Troiani

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Ferulic acid : CK(263) : AC(147)

Diseases : Cancers: Drug Resistant : CK(924) : AC(668), Chemotherapy-Induced Toxicity: Cisplatin : CK(1246) : AC(601)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Chemoprotective Agents : CK(4278) : AC(1621), Chemosensitizer : CK(1657) : AC(1270), Heme oxygenase-1 up-regulation : CK(1336) : AC(776), NF-kappaB Inhibitor : CK(5952) : AC(3464), Nrf2 activation : CK(3156) : AC(1794)

The effect of Curcuma longa on inflammatory mediators and immunological, oxidant, and antioxidant biomarkers in asthmatic rats.

Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:4234326. Epub 2021 Nov 12. PMID: 34804178

Article Published Date : Dec 31, 2020

Authors : Mohammad Hossein Boskabady, Fatemeh Amin, Farzaneh Shakeri

Study Type : Animal Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Asthma : CK(3242) : AC(707)

Pharmacological Actions : Anti-Asthmatic Agents : CK(510) : AC(148), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

The effect of curcumin as an adjunct in the treatment of chronic periodontitis.

Pubmed Data : Saudi Dent J. 2021 Nov ;33(7):375-385. Epub 2021 Jul 14. PMID: 34803277

Article Published Date : Oct 31, 2021

Authors : Sherry Terby, Mohammed Shereef, Venkitachalam Ramanarayanan, Biju Balakrishnan

Study Type : Meta Analysis, Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Periodontitis : CK(1328) : AC(311)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

The effect of curcumin supplementation on clinical outcomes and inflammatory markers in patients with ulcerative colitis.

Pubmed Data : Phytother Res. 2020 May ;34(5):1123-1133. Epub 2019 Dec 4. PMID: 31802559

Article Published Date : Apr 30, 2020

Authors : Narges Sadeghi, Anahita Mansoori, Aliakbar Shayesteh, Seyed Jalal Hashemi

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : C-Reactive Protein : CK(3950) : AC(392), Ulcerative Colitis : CK(1411) : AC(447)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Significant Treatment Outcome : CK(4297) : AC(505)

The effects of curcumin on diabetes mellitus: a systematic review.

Pubmed Data : Front Endocrinol (Lausanne). 2021 ;12:669448. Epub 2021 May 3. PMID: 34012421

Article Published Date : Dec 31, 2020

Authors : Ledyane Taynara Marton, Laís Maria Pescinini-E-Salzedas, Maria Eduarda Côrtes Camargo, Sandra M Barbalho, Jesselina F Dos Santos Haber, Renata Vargas Sinatora, Claudia Rucco Penteado Detregiachi, Raul J S Girio, Daniela Vieira Buchaim, Patricia Cincotto Dos Santos Bueno

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Diabetes Mellitus: Type 1 : CK(2032) : AC(611), Diabetes Mellitus: Type 2 : CK(12953) : AC(2579)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anticholesteremic Agents : CK(4093) : AC(669), Antioxidants : CK(34551) : AC(14499)

The effects of curcumin on inflammasome: latest update.

Pubmed Data : Molecules. 2023 Jan 11 ;28(2). Epub 2023 Jan 11. PMID: 36677800

Article Published Date : Jan 10, 2023

Authors : Tarek Benameur, Socorro Vanesca Frota Gaban, Giulia Giacomucci, Francesca Martina Filannino, Teresa Trotta, Rita Polito, Giovanni Messina, Chiara Porro, Maria Antonietta Panaro

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Arthritis : CK(5826) : AC(1505), Inflammation : CK(16108) : AC(5498), Neurodegenerative Diseases : CK(13103) : AC(4279), Respiratory Diseases : CK(826) : AC(151)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Interleukin-18 down-regulation : CK(372) : AC(183), Interleukin-1 beta downregulation : CK(6063) : AC(2940)

The effects of curcumin plus piperine co-administration on inflammation and oxidative stress.

Pubmed Data : Curr Med Chem. 2024 Mar 29. Epub 2024 Mar 29. PMID: 38561618

Article Published Date : Mar 28, 2024

Authors : Hossein Hosseini, Farideh Ghavidel, Arezoo Rajabian, Masoud Homayouni-Tabrizi, Muhammed Majeed, Amirhossein Sahebkar

Study Type : Meta Analysis, Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Piperine : CK(600) : AC(258)

Diseases : Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

The effects of curcumin supplementation on inflammatory markers in systemic lupus erythematosus patients.

Pubmed Data : Eur J Nutr. 2024 Nov 15 ;64(1):8. Epub 2024 Nov 15. PMID: 39546036

Article Published Date : Nov 14, 2024

Authors : Sima Sedighi, Zeinab Faramarzipalangar, Elahe Mohammadi, Vahideh Aghamohammadi, Mehdi Gholami Bahnemiri, Kamran Mohammadi

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : C-Reactive Protein : CK(3950) : AC(392), Inflammation : CK(16108) : AC(5498), Systemic Lupus Erythematosus : CK(817) : AC(139)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

The emerging role of curcumin in the modulation of TLR-4 signaling pathway.

Pubmed Data : Int J Mol Sci. 2020 Mar 26 ;21(7). Epub 2020 Mar 26. PMID: 32225104

Article Published Date : Mar 25, 2020

Authors : Maria Antonietta Panaro, Addolorata Corrado, Tarek Benameur, Cantatore Francesco Paolo, Daniela Cici, Chiara Porro

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain Inflammation : CK(1784) : AC(928), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949)

The ethanolic extract of Curcuma longa grown in Korea exhibits anti-neuroinflammatory effects.

Pubmed Data : BMC Complement Med Ther. 2022 Dec 30 ;22(1):343. Epub 2022 Dec 30. PMID: 36585647

Article Published Date : Dec 29, 2022

Authors : Kwan-Woo Kim, Young-Seob Lee, Dahye Yoon, Geum-Soog Kim, Dae Young Lee

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain Inflammation : CK(1784) : AC(928), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Interleukin-6 Downregulation : CK(9337) : AC(3613), NF-kappaB Inhibitor : CK(5952) : AC(3464), Nrf2 activation : CK(3156) : AC(1794), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

The evidence suggests a protective effect of curcumin in the control of epileptic seizures.

Pubmed Data : Adv Exp Med Biol. 2021 ;1291:363-373. PMID: 34331701

Article Published Date : Dec 31, 2020

Authors : Fatemeh Forouzanfar, Muhammed Majeed, Tannaz Jamialahmadi, Amirhosein Sahebkar

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Epilepsy : CK(1199) : AC(327)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Immunomodulatory : CK(6531) : AC(2360), Neuroprotective Agents : CK(20061) : AC(7949)

The evidence suggests that increased consumption of these compounds might lead to a safe strategy to delay the onset of AD.

Pubmed Data : CNS Neurol Disord Drug Targets. 2014 ;13(7):1175-91. PMID: 25230232

Article Published Date : Dec 31, 2013

Authors : Nadine Apetz, Gerald Munch, Suresh Govindaraghavan, Erika Gyengesi

Study Type : Review

Additional Links

Substances : Catechin : CK(965) : AC(313), Curcumin : CK(7239) : AC(3319), Ginkgo biloba : CK(2047) : AC(658), Green Tea : CK(4491) : AC(1379), Polyunsaturated Fatty Acids (PUFAs) : CK(383) : AC(73), Turmeric : CK(9427) : AC(3904)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

The findings of the present trial suggested that curcumin may exert immunomodulatory effects via altering the circulating concentrations of IL-1β, IL-4, and VEGF.

Pubmed Data : ScientificWorldJournal. 2014 ;2014:898361. Epub 2014 Feb 11. PMID: 24678280

Article Published Date : Dec 31, 2013

Authors : Shiva Ganjali, Amirhossein Sahebkar, Elahe Mahdipour, Khadijeh Jamialahmadi, Sepideh Torabi, Saeed Akhlaghi, Gordon Ferns, Seyed Mohammad Reza Parizadeh, Majid Ghayour-Mobarhan

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Obesity : CK(11004) : AC(2672)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-4 downregulation : CK(460) : AC(173), VEGFR3 inhibition : CK(12) : AC(3)

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(3243) : AC(656)

The findings suggested that turmeric dressings could be a potential candidate for wound healing.

Pubmed Data : Polymers (Basel). 2023 Feb 22 ;15(5). Epub 2023 Feb 22. PMID: 36904331

Article Published Date : Feb 21, 2023

Authors : Piyachat Chuysinuan, Chalinan Pengsuk, Kriengsak Lirdprapamongkol, Thanyaluck Thanyacharoen, Supanna Techasakul, Jisnuson Svasti, Patcharakamon Nooeaid

Study Type : In Vitro Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Substances : Apricot : CK(32) : AC(15), Arctigenin : CK(160) : AC(107), beta-Carotene : CK(541) : AC(99), Burdock : CK(216) : AC(116), Curcumin : CK(7239) : AC(3319), EGCG (Epigallocatechin gallate) : CK(1587) : AC(820), Garlic : CK(2194) : AC(727), Ginseng : CK(4190) : AC(1902), Licorice : CK(1110) : AC(506), Quinic acid : CK(2) : AC(2), Turmeric : CK(9427) : AC(3904)

Pharmacological Actions : Anti-Bacterial Agents : CK(4228) : AC(1989), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

The immunomodulatory and anti-Inflammatory effect of curcumin on immune cell populations, cytokines.

Pubmed Data : Pharmaceuticals (Basel). 2021 Apr 1 ;14(4). Epub 2021 Apr 1. PMID: 33915757

Article Published Date : Mar 31, 2021

Authors : Sebastian Makuch, Kamil Więcek, Marta Woźniak

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Rheumatoid Arthritis : CK(2322) : AC(562)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360)

The immunomodulatory potential of selected bioactive plant-based compounds in breast cancer.

Pubmed Data : Anticancer Agents Med Chem. 2017 ;17(6):770-783. PMID: 27539316

Article Published Date : Dec 31, 2016

Authors : Yushau Shuaibu Baraya, Kah Keng Wong, Nik Soriani Yaacob

Study Type : Review

Additional Links

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Chemotherapeutic : CK(4390) : AC(1635), Immunomodulatory : CK(6531) : AC(2360)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

The impact of curcumin on immune response: an immunomodulatory strategy to treat sepsis.

Pubmed Data : Int J Mol Sci. 2022 Nov 25 ;23(23). Epub 2022 Nov 25. PMID: 36499036

Article Published Date : Nov 24, 2022

Authors : Alessandro Allegra, Giuseppe Mirabile, Roberta Ettari, Giovanni Pioggia, Sebastiano Gangemi

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Sepsis : CK(1436) : AC(491)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Immunomodulatory : CK(6531) : AC(2360)

The impact of curcumin on the inflammatory profile of SW982 cells.

Pubmed Data : J Immunol Res. 2022 ;2022:1208970. Epub 2022 Apr 12. PMID: 35450396

Article Published Date : Dec 31, 2021

Authors : Kamil Więcek, Piotr Kupczyk, Grzegorz Chodaczek, Marta Woźniak

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Rheumatoid Arthritis : CK(2322) : AC(562)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

The impact of curcumin supplementation on systemic lupus erythematosus and lupus nephritis.

Pubmed Data : Lupus. 2023 Apr ;32(5):644-657. Epub 2023 Mar 3. PMID: 36867423

Article Published Date : Mar 31, 2023

Authors : Nina Ramessar, Abhilasha Borad, Naomi Schlesinger

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Lupus Erythematosus: Systemic : CK(787) : AC(139)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613)

The impact of curcumin, resveratrol, and cinnamon on modulating oxidative stress and antioxidant activity in type 2 diabetes,

Pubmed Data : Antioxidants (Basel). 2024 Apr 24 ;13(5). Epub 2024 Apr 24. PMID: 38790615

Article Published Date : Apr 23, 2024

Authors : Michalina Banaszak, Ilona Górna, Dagmara Woźniak, Juliusz Przysławski, Sławomira Drzymała-Czyż

Study Type : Review

Additional Links

Substances : Cinnamon : CK(692) : AC(202), Curcumin : CK(7239) : AC(3319), Resveratrol : CK(3228) : AC(1513)

Diseases : Diabetes: Oxidative Stress : CK(635) : AC(244), Diabetes Mellitus: Type 2 : CK(12953) : AC(2579)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hypoglycemic Agents : CK(9221) : AC(2076), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Enhancer : CK(73) : AC(26)

The information presented in this paper identifies curcumin as a promising renoprotective molecule against renal injury.

Pubmed Data : Redox Biol. 2013 ;1:448-56. Epub 2013 Sep 17. PMID: 24191240

Article Published Date : Dec 31, 2012

Authors : Joyce Trujillo, Yolanda Irasema Chirino, Eduardo Molina-Jijón, Ana Cristina Andérica-Romero, Edilia Tapia, José Pedraza-Chaverrí

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Liver Damage : CK(4109) : AC(1872), Liver Damage: Drug-Induced : CK(651) : AC(285), Liver Disease : CK(367) : AC(117), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Chemoprotective Agents : CK(4278) : AC(1621), Renoprotective : CK(4544) : AC(1971)

The inhibitory effects of curcumin support its utility as a prophylactic and therapeutic agent for inflammatory bone diseases such as periodontitis.

Pubmed Data : J Pharm Bioallied Sci. 2015 Aug ;7(Suppl 2):S554-8. PMID: 26538916

Article Published Date : Jul 31, 2015

Authors : M Nagasri, M Madhulatha, S V V S Musalaiah, P Aravind Kumar, C H Murali Krishna, P Mohan Kumar

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Dental Plaque : CK(356) : AC(43), Periodontitis : CK(1328) : AC(311)

Pharmacological Actions : Anti-Bacterial Agents : CK(4228) : AC(1989), Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

The molecular mechanisms of curcumins suppressive effects on tumorigenesis, angiogenesis and metastasis, focusing on NF-κB pathway.

Pubmed Data : Cytokine Growth Factor Rev. 2016 Jan 2. Epub 2016 Jan 2. PMID: 26774676

Article Published Date : Jan 01, 2016

Authors : Yunes Panahi, Behrad Darvishi, Mostafa Ghanei, Narges Jowzi, Fatemeh Beiraghdar, Behrang Shiri Varnamkhasti

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cancers: All : CK(36404) : AC(14363), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Chemopreventive : CK(6580) : AC(2166), NF-kappaB Inhibitor : CK(5952) : AC(3464)

The multifaceted role of curcumin in advanced nanocurcumin form in the treatment and management of chronic disorders.

Pubmed Data : Molecules. 2021 Nov 24 ;26(23). Epub 2021 Nov 24. PMID: 34885693

Article Published Date : Nov 23, 2021

Authors : Priti Tagde, Pooja Tagde, Fahadul Islam, Sandeep Tagde, Muddaser Shah, Zareen Delawar Hussain, Md Habibur Rahman, Agnieszka Najda, Ibtesam S Alanazi, Mousa O Germoush, Hanan R H Mohamed, Mardi M Algandaby, Mohammed Z Nasrullah, Natalia Kot, Mohamed M Abdel-Daim

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cancers: All : CK(36404) : AC(14363), Chronic Disease : CK(216) : AC(57), Neurodegenerative Diseases : CK(13103) : AC(4279)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

The novel curcumin analog c26 has remarkable protective effects on lipopolysaccharide induced acute lung injury in rats.

Pubmed Data : Respir Res. 2015 ;16:43. Epub 2015 Mar 24. PMID: 25889862

Article Published Date : Dec 31, 2014

Authors : Yali Zhang, Dandan Liang, Lili Dong, Xiangting Ge, Fengli Xu, Wenbo Chen, Yuanrong Dai, Huameng Li, Peng Zou, Shulin Yang, Guang Liang

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Acute Respiratory Distress Syndrome : CK(209) : AC(48), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875), Lung Injury: Acute : CK(533) : AC(253)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Additional Keywords : Gene Expression Regulation : CK(1401) : AC(623)

The potential therapeutic effects of curcumin on pregnancy complications.

Pubmed Data : IUBMB Life. 2020 Oct 27. Epub 2020 Oct 27. PMID: 33107698

Article Published Date : Oct 26, 2020

Authors : Zahra Ghaneifar, Zahra Yousefi, Fatemeh Tajik, Banafsheh Nikfar, Fatemeh Ghalibafan, Elham Abdollahi, Amir Abbas Momtazi-Borojeni

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Pregnancy Complications : CK(662) : AC(89)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

The potential use of a curcumin-piperine combination as an antimalarial agent.

Pubmed Data : J Trop Med. 2021 ;2021:9135617. Epub 2021 Oct 11. PMID: 34671402

Article Published Date : Dec 31, 2020

Authors : Shafia Khairani, Nisa Fauziah, Hesti Lina Wiraswati, Ramdan Panigoro, Endang Yuni Setyowati, Afiat Berbudi

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Piperine : CK(600) : AC(258)

Diseases : Malaria : CK(303) : AC(135)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antimalarials : CK(125) : AC(78), Antioxidants : CK(34551) : AC(14499)

The present review explores the potential anti-metastatic mechanisms of curcumin.

Pubmed Data : Anticancer Res. 2016 Nov ;36(11):5639-5647. PMID: 27793885

Article Published Date : Oct 31, 2016

Authors : Y I Deng, Elise Verron, Ramin Rohanizadeh

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cancers: All : CK(36404) : AC(14363)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anti-metastatic : CK(2870) : AC(2182), Interleukin-6 Downregulation : CK(9337) : AC(3613), Interleukin-8 downregulation : CK(1107) : AC(402), MicroRNA modulator : CK(1560) : AC(897), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Additional Keywords : Natural Substance/Drug Synergy : CK(1526) : AC(720)

The present review focuses on pre-clinical and clinical trials on curcumin supplementation in T2DM.

Pubmed Data : Nutrients. 2019 Aug 8 ;11(8). Epub 2019 Aug 8. PMID: 31398884

Article Published Date : Aug 07, 2019

Authors : Francesca Pivari, Alessandra Mingione, Caterina Brasacchio, Laura Soldati

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Diabetes Mellitus: Type 2 : CK(12953) : AC(2579)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963), Hepatoprotective : CK(8989) : AC(3831), Hypoglycemic Agents : CK(9221) : AC(2076), Immunomodulatory : CK(6531) : AC(2360), Renoprotective : CK(4544) : AC(1971)

The present review provides a comprehensive overview of the effects of curcumin on different immune cells and immune system-related diseases.

Pubmed Data : J Cell Physiol. 2017 Jan 6. Epub 2017 Jan 6. PMID: 28059453

Article Published Date : Jan 05, 2017

Authors : Elham Abdollahi, Amir Abbas Momtazi, Thomas P Johnston, Amirhossein Sahebkar

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Autoimmune Diseases : CK(12040) : AC(2692), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360)

The present review supports that targeting chronic inflammation may have a broad application prospect for the prevention and treatment of cancer.

Pubmed Data : Sci China Life Sci. 2017 Jun ;60(6):601-616. Epub 2017 May 29. PMID: 28639101

Article Published Date : May 31, 2017

Authors : Yong Zhang, Weijia Kong, Jiandong Jiang

Study Type : Review

Additional Links

Substances : Andrographolide : CK(251) : AC(179), Curcumin : CK(7239) : AC(3319), Green Tea : CK(4491) : AC(1379)

Diseases : Cancers: All : CK(36404) : AC(14363), Inflammation : CK(16108) : AC(5498)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anti-Inflammatory Agents : CK(39737) : AC(15858), Anti-Inflammatory Agents : CK(39737) : AC(15858), CURCUMIN : CK(25) : AC(18), CURCUMIN : CK(25) : AC(18), Inflammation : CK(128) : AC(57)

The present study provides new insight towards anti-asthmatic potential of intranasal curcumin at lower doses.

Pubmed Data : Int Immunopharmacol. 2016 Jan 4 ;31:200-206. Epub 2016 Jan 4. PMID: 26761722

Article Published Date : Jan 03, 2016

Authors : Subhashini, Preeti S Chauhan, D Dash, B N Paul, Rashmi Singh

Study Type : Insect Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Asthma : CK(3242) : AC(707)

Pharmacological Actions : Anti-Asthmatic Agents : CK(510) : AC(148), Anti-Inflammatory Agents : CK(39737) : AC(15858)

The present systematic review suggests that curcumin could be used as a safe agent to treat rheumatoid arthritis.

Pubmed Data : Adv Exp Med Biol. 2021 ;1291:251-263. PMID: 34331695

Article Published Date : Dec 31, 2020

Authors : Mohammad Bagherniya, Mina Darand, Gholamreza Askari, Paul C Guest, Thozhukat Sathyapalan, Amirhossein Sahebkar

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Rheumatoid Arthritis : CK(2322) : AC(562)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

The preventive and therapeutic potential of polyphenolic nutraceuticals in Alzheimer's disease.

Pubmed Data : Adv Protein Chem Struct Biol. 2017 ;108:33-57. Epub 2017 Mar 22. PMID: 28427563

Article Published Date : Dec 31, 2016

Authors : Yousef Sawikr, Nagendra Sastry Yarla, Ilaria Peluso, Mohammad Amjad Kamal, Gjumrakch Aliev, Anupam Bishayee

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Flavonoids : CK(4698) : AC(2176), Piperine : CK(600) : AC(258), Polyphenols : CK(2736) : AC(1003), Resveratrol : CK(3228) : AC(1513)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210), Brain Inflammation : CK(1784) : AC(928)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), NF-kappaB Inhibitor : CK(5952) : AC(3464)

The protective effects of water extracts of compound turmeric recipe on acute alcoholism.

Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:6641919. Epub 2021 Jan 13. PMID: 33519945

Article Published Date : Dec 31, 2020

Authors : Xian-Ting Liang, Yan-Yan Wang, Xiao-Yu Hu, Shao-Bo Wang

Study Type : Animal Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Alcoholism : CK(294) : AC(48)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Interleukin-8 downregulation : CK(1107) : AC(402), Malondialdehyde Down-regulation : CK(3028) : AC(992), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

The purpose of this review is to summarize the potential action of curcumin in endometriosis.

Pubmed Data : Int J Mol Sci. 2020 Mar 31 ;21(7). Epub 2020 Mar 31. PMID: 32244563

Article Published Date : Mar 30, 2020

Authors : Alexandre Vallée, Yves Lecarpentier

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Endometriosis : CK(579) : AC(159), Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Angiogenesis Inhibitors : CK(724) : AC(481), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Apoptotic : CK(9585) : AC(7379)

The reported data reveals multitarget activity of curcumol in cancer treatment.

Pubmed Data : Int J Biol Sci. 2019 ;15(8):1600-1609. Epub 2019 Jun 4. PMID: 31360103

Article Published Date : Dec 31, 2018

Authors : Wei Wei, Azhar Rasul, Ayesha Sadiqa, Iqra Sarfraz, Ghulam Hussain, Bushra Nageen, Xintong Liu, Nobumoto Watanabe, Zeliha Selamoglu, Muhammad Ali, Xiaomeng Li, Jiang Li

Study Type : Review

Additional Links

Substances : Curcumol : CK(109) : AC(78)

Diseases : Cancers: All : CK(36404) : AC(14363)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Apoptotic : CK(9585) : AC(7379), Chemopreventive : CK(6580) : AC(2166), NF-kappaB Inhibitor : CK(5952) : AC(3464)

The results indicated that the C. mangga extract has immunomodulatory effects.

Pubmed Data : Res Pharm Sci. 2021 Feb ;16(1):16-25. Epub 2020 Dec 30. PMID: 33953771

Article Published Date : Jan 31, 2021

Authors : Yuandani, Sony Eka Nugraha, Lia Laila, Denny Satria

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Hypersensitivity : CK(144) : AC(39)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-4 downregulation : CK(460) : AC(173), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

The results of this research suggest that natural extracts of E. cardamomum and C. longa possess anti-inflammatory effects.

Pubmed Data : Plants (Basel). 2021 Sep 14 ;10(9). Epub 2021 Sep 14. PMID: 34579443

Article Published Date : Sep 13, 2021

Authors : Gustavo R Cárdenas Garza, Joel H Elizondo Luévano, Aldo F Bazaldúa Rodríguez, Abelardo Chávez Montes, Raymundo A Pérez Hernández, Ameyalli J Martínez Delgado, Sonia M López Villarreal, José Rodríguez Rodríguez, Rosa M Sánchez Casas, Uziel Castillo Velázquez, Osvelia E Rodríguez Luis

Study Type : In Vitro Study

Additional Links

Substances : Cardamom : CK(55) : AC(21), Turmeric : CK(9427) : AC(3904)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Nitric Oxide Inhibitor : CK(705) : AC(356)

The results suggest that curcumin synergizes with either flavocoxid or β-caryophyllene, exerting an anti-inflammatory activity.

Pubmed Data : Front Pharmacol. 2019 ;10:1347. Epub 2019 Nov 14. PMID: 31798452

Article Published Date : Dec 31, 2018

Authors : Angela D'Ascola, Natasha Irrera, Roberta Ettari, Alessandra Bitto, Giovanni Pallio, Federica Mannino, Marco Atteritano, Giuseppe M Campo, Letteria Minutoli, Vincenzo Arcoraci, Violetta Squadrito, Giacomo Picciolo, Francesco Squadrito, Domenica Altavilla

Study Type : In Vitro Study

Additional Links

Substances : Beta-Caryophyllene : CK(171) : AC(92), Curcumin : CK(7239) : AC(3319), Flavonoids : CK(4698) : AC(2176)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464), STAT3 Inhibitor : CK(322) : AC(216)

Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

The role and mechanism of TGF-β1 in the antidepressant-like effects of tetrahydrocurcumin.

Pubmed Data : Eur J Pharmacol. 2023 Nov 15 ;959:176075. Epub 2023 Oct 5. PMID: 37802279

Article Published Date : Nov 14, 2023

Authors : Yan Yang, Jianyu Yang, Tengteng Ma, Xueke Yang, Yun Yuan, Ying Guo

Study Type : Animal Study

Additional Links

Substances : Tetrahydrocurcumin : CK(173) : AC(99)

Diseases : Depression : CK(9574) : AC(1756)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antidepressive Agents : CK(7908) : AC(1466), Brain-derived neurotrophic factor modulator : CK(745) : AC(280), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

The role of selected dietary factors in the development and course of endometriosis.

Pubmed Data : Nutrients. 2023 Jun 16 ;15(12). Epub 2023 Jun 16. PMID: 37375677

Article Published Date : Jun 15, 2023

Authors : Anna Markowska, Michał Antoszczak, Janina Markowska, Adam Huczyński

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), EGCG (Epigallocatechin gallate) : CK(1587) : AC(820), Polyphenols : CK(2736) : AC(1003), Quercetin : CK(1876) : AC(855), Resveratrol : CK(3228) : AC(1513), Vitamin C : CK(6066) : AC(1408), Vitamin E : CK(3040) : AC(571)

Diseases : Endometriosis : CK(579) : AC(159)

Pharmacological Actions : Analgesics : CK(9680) : AC(1472), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

The role of tetrahydrocurcumin in disease prevention and treatment.

Pubmed Data : Food Funct. 2024 Jul 1 ;15(13):6798-6824. Epub 2024 Jul 1. PMID: 38836693

Article Published Date : Jun 30, 2024

Authors : Mengting Zhou, Rui Li, Hua Hua, Ying Dai, Zhujun Yin, Li Li, Jin Zeng, Mengni Yang, Junning Zhao, Ruirong Tan

Study Type : Review

Additional Links

Substances : Tetrahydrocurcumin : CK(173) : AC(99)

Diseases : Cancers: All : CK(36404) : AC(14363), Inflammation : CK(16108) : AC(5498), Metabolic Diseases : CK(1273) : AC(272), Metabolic Diseases : CK(1273) : AC(272)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

The significant role of nutraceutical compounds in ulcerative colitis treatment.

Pubmed Data : Curr Med Chem. 2021 Dec 27. Epub 2021 Dec 27. PMID: 34961429

Article Published Date : Dec 26, 2021

Authors : Azzurra Chiara De Maio, Giovanna Basile, Domenico Iacopetta, Alessia Catalano, Jessica Ceramella, Danilo Cafaro, Carmela Saturnino, Maria Stefania Sinicropi

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Naringenin : CK(704) : AC(394), Oleuropein : CK(322) : AC(202)

Diseases : Ulcerative Colitis : CK(1411) : AC(447)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

The study revealed that curcumin exerted antidepressant-like effects in CMS rats, partially due to its anti-inflammatory aptitude.

Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2013 Dec 2 ;47:33-9. Epub 2013 Jul 20. PMID: 23876788

Article Published Date : Dec 01, 2013

Authors : Hong Jiang, Zhen Wang, Yihe Wang, Kai Xie, Qingrui Zhang, Qinsong Luan, Wenqiang Chen, Dexiang Liu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Stress : CK(1192) : AC(198)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antidepressive Agents : CK(7908) : AC(1466), MicroRNA modulator : CK(1560) : AC(897), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Additional Keywords : Gene Expression Regulation : CK(1401) : AC(623)

The synergistic effects between curcumin and MSCs therapy may hold great promise as a curative combination for HCC.

Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(18):8271-9. PMID: 26745072

Article Published Date : Dec 31, 2014

Authors : Ola M Tork, Eman F Khaleel, Omnia M Abdelmaqsoud

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Liver Cancer : CK(3119) : AC(1641)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

The use of curcumin for the Ttreatment of renal disorders.

Pubmed Data : Adv Exp Med Biol. 2021 ;1291:327-343. PMID: 34331699

Article Published Date : Dec 31, 2020

Authors : Mohammad Bagherniya, Davood Soleimani, Mohammad Hossein Rouhani, Gholamreza Askari, Thozhukat Sathyapalan, Amirhossein Sahebkar

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Diabetic Nephropathy : CK(1405) : AC(539), Proteinuria : CK(177) : AC(33)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

The use of polyphenols might represent a promising strategy to contrast the development or to prevent malignant mesothelioma.

Pubmed Data : Nutrients. 2016 ;8(5). Epub 2016 May 9. PMID: 27171110

Article Published Date : Dec 31, 2015

Authors : Monica Benvenuto, Rosanna Mattera, Gloria Taffera, Maria Gabriella Giganti, Paolo Lido, Laura Masuelli, Andrea Modesti, Roberto Bei

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), EGCG (Epigallocatechin gallate) : CK(1587) : AC(820), Polyphenols : CK(2736) : AC(1003), Quercetin : CK(1876) : AC(855), Resveratrol : CK(3228) : AC(1513), Rutin : CK(463) : AC(223)

Diseases : Asbestos Toxicity : CK(15) : AC(5), Mesothelioma : CK(95) : AC(34)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anticarcinogenic Agents : CK(2152) : AC(1018), Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379), Prophylactic Agents : CK(1700) : AC(335)

Additional Keywords : Dose Response : CK(1770) : AC(700)

Theranostic nanoemulsions suppress macrophage-mediated acute inflammation in rats.

Pubmed Data : J Nanobiotechnology. 2025 Feb 4 ;23(1):80. Epub 2025 Feb 4. PMID: 39905487

Article Published Date : Feb 03, 2025

Authors : Riddhi Vichare, Yalcin Kulahci, Rebecca McCallin, Fatih Zor, Fatma Nurefsan Selek, Lu Liu, Caitlin Crelli, Anneliese Troidle, Michele Herneisey, James M Nichols, Andrew J Shepherd, Vijay S Gorantla, Jelena M Janjic

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Therapeutic applications of garlic and turmeric for the diabetic wound healing in mice.

Pubmed Data : J Burn Care Res. 2022 Nov 4. Epub 2022 Nov 4. PMID: 36331804

Article Published Date : Nov 03, 2022

Authors : Muhammad A Farooq, Shaukat Ali, Rida Sulayman, Ali Hassan, Hafiz M Tahir, Hafsa Shahzad, Umaima Fiaz, Tafail A Mughal, Irfana Liaqat, Samaira Mumtaz, Tooba Nauroze, Shumaila Mumtaz

Study Type : Animal Study

Additional Links

Substances : Garlic : CK(2194) : AC(727), Turmeric : CK(9427) : AC(3904)

Diseases : Diabetic Complications : CK(4678) : AC(1606), Wound Healing : CK(4555) : AC(1412)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(944) : AC(588), Matrix Metalloproteinase-7 (MMP-7) Inhibitor : CK(32) : AC(21), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(1141) : AC(720), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Therapeutic effect of curcumin on oral diseases.

Pubmed Data : Phytother Res. 2020 Nov 17. Epub 2020 Nov 17. PMID: 33205472

Article Published Date : Nov 16, 2020

Authors : Weilong Tang, Minquan Du, Shuang Zhang, Han Jiang

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Oral Cancer : CK(717) : AC(384), Periodontal Diseases : CK(808) : AC(203)

Pharmacological Actions : Anti-Bacterial Agents : CK(4228) : AC(1989), Anti-Inflammatory Agents : CK(39737) : AC(15858), Anticarcinogenic Agents : CK(2152) : AC(1018), Antioxidants : CK(34551) : AC(14499), Chemopreventive : CK(6580) : AC(2166)

Therapeutic effects of curcumin liposomes and nanocrystals on inflammatory osteolysis.

Pubmed Data : Pharmacol Res. 2023 Jun ;192:106778. Epub 2023 Apr 23. PMID: 37094714

Article Published Date : May 31, 2023

Authors : Shan Huang, Dongdong Xu, Li Zhang, Liang Hao, Yujie Jia, Xianlong Zhang, Tao Cheng, Jian Chen

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Bone Diseases : CK(333) : AC(105), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Osteoprotective : CK(2037) : AC(685)

Therapeutic effects of curcumin on sepsis and mechanisms of action.

Pubmed Data : Phytother Res. 2019 Nov ;33(11):2798-2820. Epub 2019 Aug 19. PMID: 31429161

Article Published Date : Oct 31, 2019

Authors : Arash Karimi, Ramin Ghodsi, Fateme Kooshki, Mozhdeh Karimi, Vahid Asghariazar, Ali Tarighat-Esfanjani

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Sepsis : CK(1436) : AC(491)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Additional Keywords : Phytotherapy : CK(4003) : AC(1031)

Therapeutic potential of Curcuma longa against monkeypox: antioxidant, anti-inflammatory, and computational insights.

Pubmed Data : Front Chem. 2024 ;12:1509913. Epub 2025 Jan 16. PMID: 39886556

Article Published Date : Dec 31, 2023

Authors : Farouk Boudou, Amal Belakredar, Ahcen Keziz, Linda Aissani, Huda Alsaeedi, David Cronu, Mikhael Bechelany, Ahmed Barhoum

Study Type : In Vitro Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Monkeypox : CK(7) : AC(5)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Antiviral Agents : CK(3095) : AC(1702)

Therapeutic potential of curcumin and its nanoformulations for treating oral cancer.

Pubmed Data : World J Methodol. 2023 Jun 20 ;13(3):29-45. Epub 2023 Jun 20. PMID: 37456978

Article Published Date : Jun 19, 2023

Authors : Diptasree Mukherjee, Arunkumar Krishnan

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Oral Cancer : CK(717) : AC(384)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Epidermal growth factor receptor (EGFR) inhibitor : CK(96) : AC(67), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Therapeutic potential of curcumin in eye diseases.

Pubmed Data : Cent Eur J Immunol. 2019 ;44(2):181-189. Epub 2019 Jul 30. PMID: 31530988

Article Published Date : Dec 31, 2018

Authors : Dorota M Radomska-Leśniewska, Anna Osiecka-Iwan, Anna Hyc, Agata Góźdź, Anna M Dąbrowska, Piotr Skopiński

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cataract : CK(444) : AC(123), Conjunctivitis : CK(106) : AC(20), Diabetic Retinopathy : CK(483) : AC(211), Glaucoma : CK(611) : AC(145), Macular Degeneration : CK(604) : AC(173), Pterygium : CK(3) : AC(3), Uveitis : CK(156) : AC(40)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Therapeutic potential of curcumin in major retinal pathologies.

Pubmed Data : Int Ophthalmol. 2019 Mar ;39(3):725-734. Epub 2018 Feb 5. PMID: 29404861

Article Published Date : Feb 28, 2019

Authors : Krishi V Peddada, A'sha Brown, Vivek Verma, Marcella Nebbioso

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Diabetic Retinopathy : CK(483) : AC(211), Eye Cancer : CK(5) : AC(3), Macular Degeneration : CK(604) : AC(173), Proliferative Vitreoretinopathy (PVR) : CK(6) : AC(5), Retinitis Pigmentosa : CK(106) : AC(25)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Vascular Endothelial Growth Factor Inhibitors : CK(611) : AC(335)

These findings indicate that combination therapy of ω-3 fatty acids and nano-curcumin can be considered as a promising new approach in migraine prevention.

Pubmed Data : Endocr Metab Immune Disord Drug Targets. 2019 ;19(6):874-884. PMID: 30760195

Article Published Date : Dec 31, 2018

Authors : Mina Abdolahi, Arash Jafarieh, Payam Sarraf, Mohsen Sedighiyan, Abolghasem Yousefi, Abbas Tafakhori, Hamed Abdollahi, Farahnaz Salehinia, Mahmoud Djalali

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Omega-3 Fatty Acids : CK(5655) : AC(768)

Diseases : Headache: Migraine : CK(1018) : AC(130)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Neuroprotective Agents : CK(20061) : AC(7949), Prophylactic Agents : CK(1700) : AC(335)

These findings indicated that intranasal curcumin treatment effectively helped promote diabetic corneal epithelial/nerve wound healing.

Pubmed Data : Sci Rep. 2016 ;6:29753. Epub 2016 Jul 11. PMID: 27405815

Article Published Date : Dec 31, 2015

Authors : Chuanlong Guo, Mengshuang Li, Xia Qi, Guiming Lin, Fenghua Cui, Fengjie Li, Xianggen Wu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Diabetic Complications : CK(4678) : AC(1606), Wound Healing: Delayed : CK(132) : AC(52)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

These findings offer curcumin as a new therapeutic agent with the potential of regulating astrocyte-mediated inflammatory diseases in the CNS.

Pubmed Data : Int Immunopharmacol. 2014 Sep ;22(1):230-5. Epub 2014 Jul 3. PMID: 24998635

Article Published Date : Aug 31, 2014

Authors : Mir Hadi Seyedzadeh, Zohreh Safari, Ahad Zare, Jamshid Gholizadeh Navashenaq, Seyed Alireza Razavi, Gholam Ali Kardar, Mohammad Reza Khorramizadeh

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875), Multiple Sclerosis : CK(2432) : AC(557)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(1141) : AC(720)

These findings reveal the potential of catechin, epicatechin and garlic extracts for the treatment of acute and chronic wounds.

Pubmed Data : BMC Complement Med Ther. 2023 Jun 2 ;23(1):181. Epub 2023 Jun 2. PMID: 37268940

Article Published Date : Jun 01, 2023

Authors : Prakash Monika, M N Chandraprabha, K N Chidambara Murthy

Study Type : In Vitro Study

Additional Links

Substances : Catechin : CK(965) : AC(313), Curcumin : CK(7239) : AC(3319), Epicatechin : CK(67) : AC(36), Garlic : CK(2194) : AC(727), Neem : CK(300) : AC(148), Pomegranate : CK(1800) : AC(573)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Transforming growth factor beta (TGF-β) inhibitor : CK(580) : AC(292), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

These findings suggest a possible synergistic effect of nano-curcumin and coenzyme Q10 on clinical features of migraine.

Pubmed Data : Nutr Neurosci. 2019 Jun 26:1-10. Epub 2019 Jun 26. PMID: 31241007

Article Published Date : Jun 25, 2019

Authors : Mohammad Parohan, Payam Sarraf, Mohammad Hassan Javanbakht, Abbas Rahimi Foroushani, Sakineh Ranji-Burachaloo, Mahmoud Djalali

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10 : CK(2359) : AC(412), Curcumin : CK(7239) : AC(3319)

Diseases : Headache: Migraine : CK(1018) : AC(130)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Prophylactic Agents : CK(1700) : AC(335)

Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

These RCTs provide scientific evidence that supports the efficacy of turmeric extract and curcumin in the treatment of arthritis.

Pubmed Data : J Med Food. 2016 Aug ;19(8):717-29. PMID: 27533649

Article Published Date : Jul 31, 2016

Authors : James W Daily, Mini Yang, Sunmin Park

Study Type : Meta Analysis, Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)

Diseases : Arthritis : CK(5826) : AC(1505), Osteoarthritis : CK(2225) : AC(627)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

These results indicated that C. comosa and its diarylheptanoids have anti-inflammatory properties which could be exploited for clinical use.

Pubmed Data : Int Immunopharmacol. 2007 Apr ;7(4):524-31. Epub 2007 Jan 26. PMID: 17321476

Article Published Date : Mar 31, 2007

Authors : Amorntus Sodsai, Pawinee Piyachaturawat, Samaisukh Sophasan, Apichart Suksamrarn, Molvibha Vongsakul

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), NF-kappaB Inhibitor : CK(5952) : AC(3464), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

These results suggest a preventive therapeutic potential for C. longa and its constituent, curcumin in asthma.

Pubmed Data : Iran J Basic Med Sci. 2017 Feb ;20(2):155-165. PMID: 28293392

Article Published Date : Jan 31, 2017

Authors : Farzaneh Shakeri, Mohammad Soukhtanloo, Mohammad Hossein Boskabady

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)

Diseases : Asthma : CK(3242) : AC(707)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

These results suggest that curcumin may have great therapeutic potential in the treatment of diabetic retinopathy.

Pubmed Data : Ophthalmic Res. 2018 Mar 29. Epub 2018 Mar 29. PMID: 29597206

Article Published Date : Mar 28, 2018

Authors : Fang Yang, Jinqiang Yu, Feng Ke, Mei Lan, Dekun Li, Ke Tan, Jiaojiao Ling, Ying Wang, Kaili Wu, Dai Li

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Diabetic Retinopathy : CK(483) : AC(211)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hypoglycemic Agents : CK(9221) : AC(2076), Vascular Endothelial Growth Factor Inhibitors : CK(611) : AC(335)

These results suggest that intranasal curcumin protects against asthma.

Pubmed Data : Phytomedicine. 2018 Dec 1 ;51:29-38. Epub 2018 Jun 21. PMID: 30466625

Article Published Date : Nov 30, 2018

Authors : Preeti S Chauhan, D K Singh, D Dash, Rashmi Singh

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Asthma : CK(3242) : AC(707)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), NF-kappaB Inhibitor : CK(5952) : AC(3464)

These results suggest that the protective effect of curcumin on LPS-induced acute lung injury is associated with AMPK activation.

Pubmed Data : J Anesth. 2015 Sep 3. Epub 2015 Sep 3. PMID: 26335543

Article Published Date : Sep 02, 2015

Authors : Joungmin Kim, Seong-Wook Jeong, Hui Quan, Cheol-Won Jeong, Jeong-Il Choi, Hong-Beom Bae

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

This experiment provided evidence for the addition of curcumin in the diet to enhance the antitumor efficacy of sorafenib.

Pubmed Data : Food Funct. 2020 Jul 22 ;11(7):6422-6432. PMID: 32613952

Article Published Date : Jul 21, 2020

Authors : Shuli Man, Jingwen Yao, Panpan Lv, Yu Liu, Li Yang, Long Ma

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Liver Cancer : CK(3119) : AC(1641)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Chemosensitizer : CK(1657) : AC(1270), Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor : CK(363) : AC(237), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613)

Additional Keywords : Chemothapeutic Synergy: Sorafenib : CK(117) : AC(76), Tumor Microenvironment : CK(170) : AC(121)

This meta-analysis of RCTs suggested a significant effect of curcumin in lowering circulating TNF-α concentration.

Pubmed Data : Pharmacol Res. 2016 Mar 26 ;107:234-242. Epub 2016 Mar 26. PMID: 27025786

Article Published Date : Mar 25, 2016

Authors : Amirhossein Sahebkar, Arrigo F G Cicero, Luis E Simental-Mendía, Bharat B Aggarwal, Subash C Gupta

Study Type : Meta Analysis

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

This paper aims to further elucidate the anti-inflammatory molecular mechanisms of Curcumin.

Pubmed Data : Acta Pharm Sin B. 2015 Nov ;5(6):590-5. Epub 2015 Oct 21. PMID: 26713275

Article Published Date : Oct 31, 2015

Authors : Yanxiong Gan, Shichao Zheng, Jan P A Baak, Silei Zhao, Yongfeng Zheng, Nini Luo, Wan Liao, Chaomei Fu

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Substances : Broccoli : CK(1995) : AC(713), Curcumin : CK(7239) : AC(3319), EGCG (Epigallocatechin gallate) : CK(1587) : AC(820), Polyunsaturated Fatty Acids (PUFAs) : CK(383) : AC(73), Sulforaphane : CK(1344) : AC(630), Vitamin A : CK(945) : AC(155), Vitamin D : CK(11762) : AC(1712), Vitamin E : CK(3040) : AC(571)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

This paper focused on the potential role of flavonoids in managing diabetic wounds and discussed their possible mechanism of action.

Pubmed Data : Curr Top Med Chem. 2023 ;23(8):690-710. PMID: 37114791

Article Published Date : Dec 31, 2022

Authors : Nongmaithem Randhoni Chanu, Pal Gogoi, Pervej Alom Barbhuiya, Partha Pratim Dutta, Manash Pratim Pathak, Saikat Sen

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Flavonoids : CK(4698) : AC(2176), Hesperidin : CK(953) : AC(360), Luteolin : CK(711) : AC(393), Quercetin : CK(1876) : AC(855)

Diseases : Diabetic Complications : CK(4678) : AC(1606), Wound Healing : CK(4555) : AC(1412)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

This review focuses on the different targets of curcumin to treat cancer.

Pubmed Data : Asian Pac J Cancer Prev. 2016 ;17(6):2735-9. PMID: 27356682

Article Published Date : Dec 31, 2015

Authors : Muhammad Imran Qadir, Syeda Tahira Qousain Naqvi, Syed Aun Muhammad

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cancers: All : CK(36404) : AC(14363)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anticarcinogenic Agents : CK(2152) : AC(1018), Antioxidants : CK(34551) : AC(14499), Chemopreventive : CK(6580) : AC(2166)

This review highlights specific biological processes that could be exploited as targets for the prevention and therapy of cancer.

Pubmed Data : Semin Cancer Biol. 2015 Apr 10. Epub 2015 Apr 10. PMID: 25865775

Article Published Date : Apr 09, 2015

Authors : Stephanie C Casey, Amedeo Amedei, Katia Aquilano, Asfar S Azmi, Fabian Benencia, Dipita Bhakta, Alan E Bilsland, Chandra S Boosani, Sophie Chen, Maria Rosa Ciriolo, Sarah Crawford, Hiromasa Fujii, Alexandros G Georgakilas, Gunjan Guha, Dorota Halicka, William G Helferich, Petr Heneberg, Kanya Honoki, W Nicol Keith, Sid P Kerkar, Sulma I Mohammed, Elena Niccolai, Somaira Nowsheen, H P Vasantha Rupasinghe, Abbas Samadi, Neetu Singh, Wamidh H Talib, Vasundara Venkateswaran, Richard L Whelan, Xujuan Yang, Dean W Felsher

Study Type : Review

Additional Links

Substances : Berberine : CK(2483) : AC(1079), Curcumin : CK(7239) : AC(3319), EGCG (Epigallocatechin gallate) : CK(1587) : AC(820), Genistein : CK(945) : AC(434), Naringenin : CK(704) : AC(394), Piperine : CK(600) : AC(258), Resveratrol : CK(3228) : AC(1513)

Diseases : Cancers: All : CK(36404) : AC(14363)

Pharmacological Actions : Angiogenesis Inhibitors : CK(724) : AC(481), Anti-Inflammatory Agents : CK(39737) : AC(15858), Anti-metastatic : CK(2870) : AC(2182), Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379)

Additional Keywords : Tumor Microenvironment : CK(170) : AC(121)

This review highlights the current knowledge on the potential effects of the natural compound curcumin on cognition.

Pubmed Data : Nutrients. 2021 Apr 30 ;13(5). Epub 2021 Apr 30. PMID: 33946356

Article Published Date : Apr 29, 2021

Authors : Alessandra Berry, Barbara Collacchi, Roberta Masella, Rosaria Varì, Francesca Cirulli

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210), Brain Inflammation : CK(1784) : AC(928), Cognitive Decline/Dysfunction : CK(5382) : AC(1059)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

This review illustrates that curcumin modulating microglia and astrocytes could assure the treatment of chronic pain by suppressing spinal neuroinflammation.

Pubmed Data : Pharmaceuticals (Basel). 2021 Aug 7 ;14(8). Epub 2021 Aug 7. PMID: 34451874

Article Published Date : Aug 06, 2021

Authors : Hasriadi, Peththa Wadu Dasuni Wasana, Opa Vajragupta, Pornchai Rojsitthisak, Pasarapa Towiwat

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Brain Inflammation : CK(1784) : AC(928), Chronic Pain : CK(1524) : AC(284)

Pharmacological Actions : Analgesics : CK(9680) : AC(1472), Anti-Inflammatory Agents : CK(39737) : AC(15858)

This review provides evidence that nutrition and natural compounds can help in prevention and treatment of this neuroinflammatory disease.

Pubmed Data : Pharmacol Ther. 2015 Apr ;148:85-113. Epub 2014 Nov 27. PMID: 25435020

Article Published Date : Mar 31, 2015

Authors : Katja Schmitz, Julia Barthelmes, Leonie Stolz, Susanne Beyer, Olaf Diehl, Irmgard Tegeder

Study Type : Review

Additional Links

Diseases : Encephalomyelitis : CK(110) : AC(57), Multiple Sclerosis : CK(2432) : AC(557)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360)

Additional Keywords : Dietary Modification : CK(388) : AC(59), Natural Substance Synergy : CK(1400) : AC(669), Significant Treatment Outcome : CK(4297) : AC(505)

This review summarizes the current knowledge on the effect of curcumin in the treatment and prevention of inflammation, neurodegenerative diseases and cancers.

Pubmed Data : Curr Pharmacol Rep. 2015 Apr ;1(2):129-139. Epub 2015 Jan 30. PMID: 26457241

Article Published Date : Mar 31, 2015

Authors : Sarandeep S S Boyanapalli, Ah-Ng Tony Kong

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cancers: All : CK(36404) : AC(14363), Inflammation : CK(16108) : AC(5498), Neurodegenerative Diseases : CK(13103) : AC(4279)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Chemopreventive : CK(6580) : AC(2166), Histone deacetylase inhibitor : CK(113) : AC(81), Neuroprotective Agents : CK(20061) : AC(7949)

Additional Keywords : Epigenetic Modification : CK(586) : AC(216)

This review summarizes the understanding of chemopreventive effects of curcumin in the prevention of cancer via the regulation of various cell signaling and genetic pathways.

Pubmed Data : Biomed Res Int. 2014 ;2014:761608. Epub 2014 Sep 10. PMID: 25295272

Article Published Date : Dec 31, 2013

Authors : Arshad H Rahmani, Mohammad A Al Zohairy, Salah M Aly, Masood A Khan

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Curcumin: Degradiation byproducts : CK(13) : AC(8)

Diseases : Cancers: All : CK(36404) : AC(14363)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Apoptotic : CK(9585) : AC(7379), Chemopreventive : CK(6580) : AC(2166), NF-kappaB Inhibitor : CK(5952) : AC(3464)

This reviews the current literature on the role of natural products in ovarian cancer chemoprevention.

Pubmed Data : Cancer Lett. 2017 Dec 28 ;411:191-200. Epub 2017 Oct 7. PMID: 29017913

Article Published Date : Dec 27, 2017

Authors : Francesca Pistollato, Ruben Calderón Iglesias, Roberto Ruiz, Silvia Aparicio, Jorge Crespo, Luis Dzul Lopez, Francesca Giampieri, Maurizio Battino

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), EGCG (Epigallocatechin gallate) : CK(1587) : AC(820), Resveratrol : CK(3228) : AC(1513), Sulforaphane : CK(1344) : AC(630)

Diseases : Ovarian Cancer : CK(1029) : AC(509)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379), Autophagy Up-regulation : CK(838) : AC(559), Chemopreventive : CK(6580) : AC(2166)

Additional Keywords : Cancer Stem Cells : CK(501) : AC(365)

This reviews the effects of curcumin on endometriosis and possible molecular mechanisms are discussed.

Pubmed Data : Biomed Pharmacother. 2017 Oct 25 ;97:91-97. Epub 2017 Oct 25. PMID: 29080464

Article Published Date : Oct 24, 2017

Authors : Tahereh Arablou, Roya Kolahdouz-Mohammadi

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)

Diseases : Endometriosis : CK(579) : AC(159)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anti-metastatic : CK(2870) : AC(2182), Antioxidants : CK(34551) : AC(14499)

This reviews the favorable results from the use of herbal and plant products in inflammatory bowel disease.

Pubmed Data : Ann Gastroenterol. 2016 Jul-Sep;29(3):268-81. Epub 2016 Feb 20. PMID: 27366027

Article Published Date : Jun 30, 2016

Authors : John K Triantafillidis, Aikaterini Triantafyllidi, Constantinos Vagianos, Apostolos Papalois

Study Type : Review

Additional Links

Substances : Aloe Vera : CK(940) : AC(254), Artemisinin : CK(108) : AC(79), Curcumin : CK(7239) : AC(3319), Frankincense : CK(1021) : AC(260), Green Tea : CK(4491) : AC(1379), Lemongrass : CK(55) : AC(32), Panax Notoginseng : CK(392) : AC(185), Wormwood : CK(102) : AC(47)

Diseases : Crohn's Disease : CK(242) : AC(55), Inflammatory Bowel Diseases : CK(3196) : AC(926), Ulcerative Colitis : CK(1411) : AC(447)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

This reviews the many different molecular aspects of curcumin in breast cancer treatments.

Pubmed Data : Anticancer Agents Med Chem. 2015 May 14 ;15(5):647-56. PMID: 25553436

Article Published Date : May 13, 2015

Authors : Parveen Kumar, Almesh Kadakol, Prashanth Krishna Shasthrula, Nitin Arunrao Mundhe, Vinayak Sudhir Jamdade, Chandana C Barua, Anil Bhanudas Gaikwad

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Pharmacological Actions : Angiogenesis Inhibitors : CK(724) : AC(481), Anti-Inflammatory Agents : CK(39737) : AC(15858), Anti-metastatic : CK(2870) : AC(2182), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Additional Keywords : Natural Substance/Drug Synergy : CK(1526) : AC(720)

This reviews the neuroprotective roles of these herbs and summarizes their anti-inflammatory, antioxidant, and anti-apoptotic effects in PD.

Pubmed Data : Am J Transl Res. 2015 ;7(7):1189-202. Epub 2015 Jul 15. PMID: 26328004

Article Published Date : Dec 31, 2014

Authors : Wenyu Fu, Wenxin Zhuang, Shuanhu Zhou, Xin Wang

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Ginsenosides : CK(2640) : AC(1452), Resveratrol : CK(3228) : AC(1513)

Diseases : Parkinson's Disease : CK(3012) : AC(1116)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

This study demonstrates a novel role for natural occurring polyphenols as PDE inhibitors that enhance pancreatic β-cell function.

Pubmed Data : J Endocrinol. 2014 Nov ;223(2):107-17. PMID: 25297556

Article Published Date : Oct 31, 2014

Authors : Michael Rouse, Antoine Younès, Josephine M Egan

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Resveratrol : CK(3228) : AC(1513)

Diseases : Diabetes Mellitus: Type 2 : CK(12953) : AC(2579)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Pancreato Protective Agents : CK(554) : AC(299), Phosphodiesterase Inhibitors : CK(2) : AC(2)

Additional Keywords : Dose Response : CK(1770) : AC(700), Gene Expression Regulation : CK(1401) : AC(623)

This study found that melatonin and curcumin can be used to quicken neural recovery and help treat nerve injury.

Pubmed Data : EXCLI J. 2019 ;18:653-665. Epub 2019 Aug 21. PMID: 31611748

Article Published Date : Dec 31, 2018

Authors : Farshad Moharrami Kasmaie, Zohreh Jahromi, Rouhollah Gazor, Arash Zaminy

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Melatonin : CK(2891) : AC(911)

Diseases : Sciatic Nerve Crush Injury : CK(211) : AC(104)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

This study identifies oral supplementation with curcumin as a potential therapeutic strategy to improve intestinal barrier function and prevent the development of metabolic diseases.

Pubmed Data : PLoS One. 2014 ;9(9):e108577. Epub 2014 Sep 24. PMID: 25251395

Article Published Date : Dec 31, 2013

Authors : Siddhartha S Ghosh, Jinghua Bie, Jing Wang, Shobha Ghosh

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Atherosclerosis : CK(2063) : AC(778), Metabolic Diseases : CK(1273) : AC(272)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Anti Therapeutic Actions : Western Diet : CK(601) : AC(151)

This study provides preliminary evidence that curcumin and maritime pine may help alleviate symptoms of Gulf War Illness.

Pubmed Data : Int J Environ Res Public Health. 2021 03 3 ;18(5). Epub 2021 Mar 3. PMID: 33802272

Article Published Date : Jan 02, 2021

Authors : Emily K Donovan, Sophia Kekes-Szabo, Joanne C Lin, Rebecca L Massey, James D Cobb, Kathleen S Hodgin, Timothy J Ness, Carl Hangee-Bauer, Jarred W Younger

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Frankincense : CK(1021) : AC(260), Pine Bark Extract : CK(1218) : AC(223)

Diseases : Gulf War Syndrome : CK(122) : AC(19)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

This study provides strong evidence that at least some of the neuroprotective effects of curcumin against OGD/R are mediated by PPARγ activation.

Pubmed Data : J Neurosci Res. 2014 Nov ;92(11):1549-59. Epub 2014 Jun 26. PMID: 24975470

Article Published Date : Oct 31, 2014

Authors : Zun-Jing Liu, Hong-Qiang Liu, Cheng Xiao, Hui-Zhen Fan, Qing Huang, Yun-Hai Liu, Yu Wang

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Hypoxia: Brain : CK(27) : AC(16)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949)

This study showed that curcumin prevent atherosclerosis progression.

Pubmed Data : Life Sci. 2020 Jul 1:117658. Epub 2020 Jul 1. PMID: 32621921

Article Published Date : Jun 30, 2020

Authors : Ya-Li Lv, Yangjie Jia, Zirui Wan, Zhuo-Ling An, Song Yang, Fei-Fei Han, Li-Li Gong, Ling-Ling Xuan, Lu-Lu Ren, Wen Zhang, He Liu, Li-Hong Liu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Atherosclerosis : CK(2063) : AC(778), Cytomegalovirus Infections : CK(133) : AC(52)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antiviral Agents : CK(3095) : AC(1702)

Three months treatment with curcumin in chronic kidney disease patients undergoing hemodialysis resulted in decreased markers of inflammation.

Pubmed Data : Clin Nutr. 2020 Mar 13. Epub 2020 Mar 13. PMID: 32204978

Article Published Date : Mar 12, 2020

Authors : Livia Alvarenga, Roberta Salarolli, Ludmila F M F Cardozo, Rhayssa S Santos, Jessyca S de Brito, Julie Ann Kemp, Drielly Reis, Bruna Regis de Paiva, Peter Stenvinkel, Bengt Lindholm, Denis Fouque, Denise Mafra

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Chronic Kidney Disease (CKD) : CK(1186) : AC(211)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Topical curcumin can inhibit deleterious effects of upper respiratory tract bacteria on human oropharyngeal cells.

Pubmed Data : Support Care Cancer. 2010 May 14. Epub 2010 May 14. PMID: 20467756

Article Published Date : May 14, 2010

Authors : Sonja Lüer, Rolf Troller, Marion Jetter, Violeta Spaniol, Christoph Aebi

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Chemotherapy-Induced Toxicity : CK(3239) : AC(1520), Mucositis : CK(152) : AC(53), Upper Respiratory Infections : CK(1905) : AC(262)

Pharmacological Actions : Anti-Bacterial Agents : CK(4228) : AC(1989), Anti-Inflammatory Agents : CK(39737) : AC(15858)

Topical delivery of tetrahydrocurcumin lipid nanoparticles effectively inhibits skin inflammation.

Pubmed Data : Drug Dev Ind Pharm. 2018 Oct ;44(10):1701-1712. Epub 2018 Jul 25. PMID: 29938544

Article Published Date : Sep 30, 2018

Authors : Vandita Kakkar, Indu Pal Kaur, Amrit Pal Kaur, Komal Saini, Kamalinder K Singh

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Tetrahydrocurcumin : CK(173) : AC(99)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Traditional herbal medicine candidates as complementary treatments for COVID-19.

Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:2560645. Epub 2020 Oct 10. PMID: 33101440

Article Published Date : Dec 31, 2019

Authors : Rhea Veda Nugraha, Hastono Ridwansyah, Mohammad Ghozali, Astrid Feinisa Khairani, Nur Atik

Study Type : Review

Additional Links

Substances : Echinacea : CK(904) : AC(237), Turmeric : CK(9427) : AC(3904)

Diseases : Coronavirus Infection : CK(3250) : AC(986)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Treatment efficacy of Thunbergia laurifolia, Curcuma longa, Garcinia mangostana, and Andrographis paniculata extracts in Staphylococcus aureus-induced dermatitis model.

Pubmed Data : Vet World. 2022 Jan ;15(1):188-197. Epub 2021 Jan 29. PMID: 35369604

Article Published Date : Dec 31, 2021

Authors : Charinya So-In, Nuchsupha Sunthamala

Study Type : Animal Study

Additional Links

Substances : Andrographis : CK(432) : AC(202), Mangosteen : CK(261) : AC(133), Turmeric : CK(9427) : AC(3904)

Diseases : Dermatitis : CK(2649) : AC(444), Staphylococcus aureus infection : CK(776) : AC(576)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Treatment with curcumin inhibited thoracic aortic aneurysm development in rats.

Pubmed Data : Mol Med Rep. 2017 Oct ;16(4):4455-4462. Epub 2017 Aug 4. PMID: 28791384

Article Published Date : Sep 30, 2017

Authors : Xiang Li, Qin Fang, Xiaohong Tian, Xiaohong Wang, Qiang Ao, Weijian Hou, Hao Tong, Jun Fan, Shuling Bai

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Aneurysm: Aortic : CK(125) : AC(40)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Vascular Endothelial Growth Factor Inhibitors : CK(611) : AC(335)

Treatment with nanoparticle curcumin suppressed the development of DSS-induced colitis.

Pubmed Data : PLoS One. 2017 ;12(10):e0185999. Epub 2017 Oct 6. PMID: 28985227

Article Published Date : Dec 31, 2016

Authors : Masashi Ohno, Atsushi Nishida, Yoshihiko Sugitani, Kyohei Nishino, Osamu Inatomi, Mitsushige Sugimoto, Masahiro Kawahara, Akira Andoh

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Colitis : CK(1542) : AC(735), Inflammatory Bowel Diseases : CK(3196) : AC(926)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Turmeric and vitamin C mitigate testicular atrophy induced by lead diacetate.

Pubmed Data : Andrologia. 2021 May 24:e14120. Epub 2021 May 24. PMID: 34028854

Article Published Date : May 23, 2021

Authors : Laila Mohamed Fadda, Reem Alsharidah, Iman Huseein Hasan

Study Type : Animal Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904), Vitamin C : CK(6066) : AC(1408)

Diseases : Testicular Injury: Chemical/Metal Induced : CK(774) : AC(385)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Problem Substances : Lead : CK(700) : AC(231)

Turmeric contains compounds which have potent anti-amyloidogenic effects indicating their value for Alzheimer disease.

Pubmed Data : Curr Alzheimer Res. 2009 Dec;6(6):564-71. PMID: 19715544

Article Published Date : Dec 01, 2009

Authors : R Douglas Shytle, Paula C Bickford, Kavon Rezai-zadeh, L Hou, Jin Zeng, Jun Tan, Paul R Sanberg, Cyndy D Sanberg, Bill Roschek, Ryan C Fink, Randall S Alberte

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Turmeric cream can be used as an alternative remedy or adjuvant therapy in mild to moderate vitiligo lesions.

Pubmed Data : J Cosmet Dermatol. 2022 Feb 1. Epub 2022 Feb 1. PMID: 35104042

Article Published Date : Jan 31, 2022

Authors : Samin Jalalmanesh, Parvin Mansouri, Mehdi Rajabi, Faezeh Monji

Study Type : Human Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Vitiligo : CK(265) : AC(48)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Turmeric extract alleviates airway inflammation via oxidative stress-driven MAPKs/MMPs pathway.

Pubmed Data : Int Immunopharmacol. 2024 Nov 15 ;141:113018. Epub 2024 Aug 30. PMID: 39216235

Article Published Date : Nov 14, 2024

Authors : Jeong-Won Kim, Ji-Soo Jeong, Jin-Hwa Kim, Chang-Yeop Kim, Eun-Hye Chung, Je-Won Ko, Tae-Won Kim

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)

Diseases : Asthma : CK(3242) : AC(707), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Turmeric extract can successfully attenuate methotrexate hepatotoxicity.

Pubmed Data : BMC Complement Altern Med. 2015;15(1):246. Epub 2015 Jul 22. PMID: 26199067

Article Published Date : Dec 31, 2014

Authors : Adel Rezaei Moghadam, Soheil Tutunchi, Ali Namvaran-Abbas-Abad, Mina Yazdi, Fatemeh Bonyadi, Daryoush Mohajeri, Mohammad Mazani, Hassan Marzban, Marek J Łos, Saeid Ghavami

Study Type : Animal Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Drug-Induced Toxicity: Methotrexate : CK(103) : AC(42), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831)

Turmeric extract exhibits anti-Alzheimer properties.

Pubmed Data : Curr Alzheimer Res. 2011 Aug 30. Epub 2011 Aug 30. PMID: 21875408

Article Published Date : Aug 30, 2011

Authors : R Douglas Shytle, J Tan, P C Bickford, K Rezai-Zadeh, L Hou, J Zeng, P R Sanberg, C D Sanberg, R S Alberte, R C Fink, B Roschek

Study Type : Transgenic Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Alzheimer's Disease : CK(5355) : AC(2210), Brain: Microglial Activation : CK(205) : AC(118), Brain Inflammation : CK(1784) : AC(928)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Neuroprotective Agents : CK(20061) : AC(7949)

Turmeric extract reduces inflammatory mediator production.

Pubmed Data : Phytomedicine. 2005 Jun;12(6-7):445-52. PMID: 16008121

Article Published Date : Jun 01, 2005

Authors : R C Lantz, G J Chen, A M Solyom, S D Jolad, B N Timmermann

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)

Diseases : Inflammation : CK(16108) : AC(5498), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Prostaglandin PGE2 downregulation : CK(194) : AC(89), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Turmeric extract regulates hepatic toxicity in a single ethanol binge rat model.

Pubmed Data : Heliyon. 2022 Sep ;8(9):e10737. Epub 2022 Sep 22. PMID: 36193527

Article Published Date : Aug 31, 2022

Authors : Hwa-Young Lee, Geum-Hwa Lee, The-Hiep Hoang, Seung Wook Kim, Choon Gil Kang, Jae Hyeok Jo, Myoung Ja Chung, Kyunghyun Min, Han-Jung Chae

Study Type : Animal Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Alcohol Toxicity : CK(1235) : AC(480), Chemically-Induced Liver Damage : CK(2304) : AC(1089)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Turmeric gel can be effectively used as an adjunct to mechanical plaque control in the prevention of plaque and gingivitis.

Pubmed Data : Natl J Maxillofac Surg. 2015 Jan-Jun;6(1):67-71. PMID: 26668456

Article Published Date : Dec 31, 2014

Authors : Vibha Singh, Anjani Kumar Pathak, Mahesh Pal, Sagar Sareen, Kopal Goel

Study Type : Human Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Dental Plaque : CK(356) : AC(43), Gingivitis : CK(628) : AC(90)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Prostaglandin PGE2 downregulation : CK(194) : AC(89)

Turmeric has a preventive effect against collagen-induced arthritis, in an experimental model.

Pubmed Data : Clin Ter. 2011 ;162(3):201-7. PMID: 21717043

Article Published Date : Jan 01, 2011

Authors : K Taty Anna, M R Elvy Suhana, S Das, O Faizah, A H Hamzaini

Study Type : Animal Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Arthritis : CK(5826) : AC(1505), Polyarthritis : CK(21) : AC(5)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Turmeric reduces inflammatory cells in hamster opisthorchiasis.

Pubmed Data : Parasitol Res. 2009 Oct;105(5):1459-63. Epub 2009 Jul 25. PMID: 19633869

Article Published Date : Oct 01, 2009

Authors : Sirintip Boonjaraspinyo, Thidarut Boonmars, Chantana Aromdee, Tuanchai Srisawangwong, Butsara Kaewsamut, Somchai Pinlaor, Puangrat Yongvanit, Anucha Puapairoj

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)

Diseases : Opisthorchiasis : CK(1) : AC(1)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Turmeric root, vitamin C, and vitamin D supplementation over 16 weeks can reduce upper respiratory symptoms, gastrointestinal symptoms in elite footballers.

Pubmed Data : Nutrients. 2024 Jan 12 ;16(2). Epub 2024 Jan 12. PMID: 38257136

Article Published Date : Jan 11, 2024

Authors : David J Clayton, Ross Burbeary, Connor Parker, Ruth M James, Chris Saward, Eleanor L Procter, William J A Mode, Carla Baker, John Hough, Neil C Williams, Harry Rossington, Ian Varley

Study Type : Human Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904), Vitamin C : CK(6066) : AC(1408), Vitamin D : CK(11762) : AC(1712)

Diseases : Upper Respiratory Infections : CK(1905) : AC(262)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Gastrointestinal Agents : CK(7657) : AC(2274)

Turmeric supplementation could be an adjuvant to T2DM on metformin treatment having a beneficial effect on blood glucose, oxidative stress and inflammation.

Pubmed Data : Indian J Clin Biochem. 2015 Apr ;30(2):180-6. Epub 2014 May 8. PMID: 25883426

Article Published Date : Mar 31, 2015

Authors : N Maithili Karpaga Selvi, M G Sridhar, R P Swaminathan, R Sripradha

Study Type : Human Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Diabetes Mellitus: Type 2 : CK(12953) : AC(2579), Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hypoglycemic Agents : CK(9221) : AC(2076)

Additional Keywords : Significant Treatment Outcome : CK(4297) : AC(505)

Turmeric supplementation with piperine is more effective than turmeric alone in attenuating oxidative stress and inflammation in hemodialysis.

Pubmed Data : Free Radic Biol Med. 2022 Nov 20 ;193(Pt 2):648-655. Epub 2022 Nov 9. PMID: 36370961

Article Published Date : Nov 19, 2022

Authors : Nayara Cristina Freitas E Silva-Santana, Hellen Christina Neves Rodrigues, Tatiane Fagundes Pereira Martins, Clarice Carneiro Braga, Marina Alves Coelho Silva, Luiz Carlos da Cunha, Ana Tereza Vaz de Souza Freitas, Nara Aline Costa, Maria do Rosário Gondim Peixoto

Study Type : Human Study

Additional Links

Substances : Piperine : CK(600) : AC(258), Turmeric : CK(9427) : AC(3904)

Diseases : C-Reactive Protein : CK(3950) : AC(392), Hemodialysis : CK(1256) : AC(130), Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Turmeric tonic could be used as a treatment of scalp psoriasis.

Pubmed Data : J Cosmet Dermatol. 2018 Apr 1. Epub 2018 Apr 1. PMID: 29607625

Article Published Date : Mar 31, 2018

Authors : Parichehr Bahraini, Mehdi Rajabi, Parvin Mansouri, Golnaz Sarafian, Reza Chalangari, Zahra Azizian

Study Type : Human Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Psoriasis : CK(922) : AC(255)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Immunomodulatory : CK(6531) : AC(2360)

Turmeric: from spice to cure. A review of the anti-cancer, radioprotective and anti-inflammatory effects of turmeric sourced compounds.

Pubmed Data : Front Nutr. 2024 ;11:1399888. Epub 2024 May 28. PMID: 38863589

Article Published Date : Dec 31, 2023

Authors : Mihai Cozmin, Ionut Iulian Lungu, Cristian Gutu, Alina Stefanache, Letitia Doina Duceac, Bogdan Dorin Șoltuzu, Daniela Damir, Gabriela Calin, Elena Roxana Bogdan Goroftei, Carmen Grierosu, Monica Boev

Study Type : Review

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)

Diseases : Cancers: All : CK(36404) : AC(14363)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anti-metastatic : CK(2870) : AC(2182), Apoptotic : CK(9585) : AC(7379), Radioprotective : CK(2398) : AC(713)

Turmeronols A and B from Curcuma longa have anti-inflammatory effects in lipopolysaccharide-stimulated BV-2 microglial cells.

Pubmed Data : Biosci Microbiota Food Health. 2023 ;42(3):172-179. Epub 2023 Jan 27. PMID: 37404570

Article Published Date : Dec 31, 2022

Authors : Ryosuke Saji, Ryusei Uchio, Arisa Fuwa, Chinatsu Okuda-Hanafusa, Kengo Kawasaki, Koutarou Muroyama, Shinji Murosaki, Yoshihiro Yamamoto, Yoshitaka Hirose

Study Type : In Vitro Study

Additional Links

Substances : Turmeric : CK(9427) : AC(3904)

Diseases : Inflammation : CK(16108) : AC(5498), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Interleukin-6 Downregulation : CK(9337) : AC(3613), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Unraveling the curcumin's molecular targets and its potential in suppressing skin inflammation.

Pubmed Data : Drug Dev Res. 2025 Feb ;86(1):e70058. PMID: 39943799

Article Published Date : Jan 31, 2025

Authors : Anjana Sureshbabu, Elena Smirnova, Do Thi Cat Tuong, Sangeetha Vinod, Sungyeon Chin, Mohammad Moniruzzaman, Kalaiselvi Senthil, Dong I Lee, Karthikeyan Adhimoolam, Taesun Min

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319)