Focused Research Topics Diabetes Mellitus: Type 2 & Curcumin

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Associated Topics included in this Focused Research

Diabetes Mellitus: Type 2

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28 Research Articles in Total

Compounds within turmeric suppress an increase in blood glucose levels in type 2 diabetic mice.

Pubmed Data : J Agric Food Chem. 2005 Feb 23;53(4):959-63. PMID: 15713005
Article Published Date : Feb 23, 2005
Authors : Tozo Nishiyama, Tatsumasa Mae, Hideyuki Kishida, Misuzu Tsukagawa, Yoshihiro Mimaki, Minpei Kuroda, Yutaka Sashida, Kazuma Takahashi, Teruo Kawada, Kaku Nakagawa, Mikio Kitahara
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Alcohol Toxicity : CK(337) : AC(125), Diabetes Mellitus: Type 2 : CK(3572) : AC(624)
Pharmacological Actions : Hypoglycemic Agents : CK(1446) : AC(342)
Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Curcumin extract for prevention of type 2 diabetes.

Pubmed Data : Diabetes Care. 2012 Nov ;35(11):2121-7. Epub 2012 Jul 6. PMID: 22773702
Article Published Date : Oct 31, 2012
Authors : Somlak Chuengsamarn, Suthee Rattanamongkolgul, Rataya Luechapudiporn, Chada Phisalaphong, Siwanon Jirawatnotai
Study Type : Human In Vitro
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Insulin Resistance : CK(1683) : AC(346), Prediabetes : CK(150) : AC(17)
Additional Keywords : Beta Cell Protection : CK(61) : AC(25), Plant Extracts : CK(7645) : AC(2539)

A combined dosage of tetrahydrocurcumin and chlorogenic acid protects against experimentally induced type 2 diabetes in rats.

Pubmed Data : Mol Cell Biochem. 2010 Aug;341(1-2):109-17. Epub 2010 Mar 26. PMID: 20339905
Article Published Date : Aug 01, 2010
Authors : Leelavinothan Pari, Krishnamoorthy Karthikesan, Venugopal P Menon
Study Type : Animal Study
Additional Links
Substances : Chlorogenic Acid : CK(13) : AC(7), Curcumin : CK(4803) : AC(2175), Tetrahydrocurcumin : CK(66) : AC(30)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Oxidative Stress : CK(3871) : AC(1382)
Pharmacological Actions : Antioxidants : CK(7529) : AC(2682)

Curcumin is a potential glucose-lowering agent and antioxidant in type 2 diabetic mice.

Pubmed Data : Phytother Res. 2008 Feb;22(2):180-4. PMID: 18398869
Article Published Date : Feb 01, 2008
Authors : Kwon-Il Seo, Myung-Sook Choi, Un Ju Jung, Hye-Jin Kim, Jiyoung Yeo, Seon-Min Jeon, Mi-Kyung Lee
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Insulin Resistance : CK(1683) : AC(346)
Pharmacological Actions : Antioxidants : CK(7529) : AC(2682), Hypoglycemic Agents : CK(1446) : AC(342)

Curcumin possesses anti-diabetic effects and mitigates diabetes complications

Pubmed Data : Curr Top Med Chem. 2015 Jun 19. Epub 2015 Jun 19. PMID: 26088351
Article Published Date : Jun 18, 2015
Authors : Seyed Fazel Nabavi, Raman Thiagarajan, Luca Rastrelli, Maria Daglia, Eduardo Sobarzo-Sanchez, Heshmatollah Alinezhad, Seyed Mohammad Nabavi
Study Type : Review
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Diabetic Complications : CK(1563) : AC(333)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682)
Additional Keywords : Advanced Glycation End Products : CK(10) : AC(1)

Curcumin supplementation could ameliorate cognitive deficits and reverse biochemical alterations in a ICV-streptozotocin Alzheimer's rat model.

Pubmed Data : Eur J Pharmacol. 2016 Jan 5 ;770:52-60. Epub 2015 Dec 2. PMID: 26638997
Article Published Date : Jan 04, 2016
Authors : Doaa M Samy, Cherine A Ismail, Rasha A Nassra, Teshreen M Zeitoun, Azhar M Nomair
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Alzheimer's Disease : CK(1292) : AC(382), Brain: Oxidative Stress : CK(79) : AC(46), Diabetes Mellitus: Type 2 : CK(3572) : AC(624)
Pharmacological Actions : Antioxidants : CK(7529) : AC(2682), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin works synergistically with insulin on muscle cell glucose metabolism.

Pubmed Data : Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2366-73. Epub 2010 Jun 1. PMID: 20561944
Article Published Date : Aug 01, 2010
Authors : Changkeun Kang, Euikyung Kim
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes Insipidus : CK(35) : AC(5), Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Insulin Resistance : CK(1683) : AC(346)
Pharmacological Actions : Antioxidants : CK(7529) : AC(2682), Hypoglycemic Agents : CK(1446) : AC(342)
Additional Keywords : Drug Synergy : CK(351) : AC(156)

Abnormal electrophysiological characteristics of VGSCs can be ameliorated efficaciously by a period of treatment with curcumin.

Pubmed Data : Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2015 Nov ;31(6):541-8. PMID: 27215022
Article Published Date : Oct 31, 2015
Authors : Bo Meng, Lu-lu Shen, Xiao-ting Shi, Yong-sheng Gong, Xiao-fang Fan, Jun Li, Hong Cao
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Neuropathic Pain : CK(271) : AC(62)

Curcumin and tetrahydrocurcumin have antihyperlipidemic properties in experimental type 2 diabetic rats.

Pubmed Data : JPEN J Parenter Enteral Nutr. 1986 Sep-Oct;10(5):530-2. PMID: 17994458
Article Published Date : Sep 01, 1986
Authors : Leelavinothan Pari, Pidaran Murugan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes: Cardiovascular Illness : CK(700) : AC(107), Diabetes Mellitus: Type 2 : CK(3572) : AC(624)
Pharmacological Actions : Hypolipidemic : CK(1288) : AC(265)

Curcumin has been demonstrated to effectively prevent or ameliorate diabetic mellitus and its complications including diabetic neuropathic pain.

Pubmed Data : Neurosci Lett. 2015 Aug 14. Epub 2015 Aug 14. PMID: 26282904
Article Published Date : Aug 13, 2015
Authors : Bo Meng, Lu-Lu Shen, Xiao-Ting Shi, Yong-Sheng Gong, Xiao-Fang Fan, Jun Li, Hong Cao
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Diabetic Neuropathy : CK(59) : AC(19), Neuropathic Pain : CK(271) : AC(62)
Pharmacological Actions : Analgesics : CK(1327) : AC(217)

Curcumin may prove useful for patients with diabetes by improving both β-cell function and relieving insulin resistance.

Pubmed Data : Nutr Diabetes. 2016 ;6:e205. Epub 2016 Apr 25. PMID: 27110686
Article Published Date : Dec 31, 2015
Authors : S Weisberg, R Leibel, D V Tortoriello
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Insulin Resistance : CK(1683) : AC(346)
Pharmacological Actions : Insulin Sensitizers : CK(350) : AC(70), Proteasome Inhibitors : CK(51) : AC(33)

Curcumin significantly downregulated the plasma membrane redox system activity in a dose-dependent manner.

Pubmed Data : Biochem Res Int. 2016;2016:6025245. Epub 2016 Jan 19. PMID: 26904287
Article Published Date : Dec 31, 2015
Authors : Prabhakar Singh, Rajesh Kumar Kesharwani, Krishna Misra, Syed Ibrahim Rizvi
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624)
Pharmacological Actions : Redox Modulator : CK(5) : AC(3)
Additional Keywords : Dose Response : CK(1056) : AC(408)

Curcumin's blood sugar lowering effect may be due to its inhibitory effect on hepatic gluconeogenesis.

Pubmed Data : Biochem Biophys Res Commun. 2009 Oct 16;388(2):377-82. Epub 2009 Aug 8. PMID: 19665995
Article Published Date : Oct 16, 2009
Authors : Teayoun Kim, Jessica Davis, Albert J Zhang, Xiaoming He, Suresh T Mathews
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes Mellitus: Type 1 : CK(1130) : AC(301), Diabetes Mellitus: Type 2 : CK(3572) : AC(624)
Pharmacological Actions : AMP-activated protein kinase modulation : CK(2) : AC(2), Gluconeogenesis Inhibitor : CK(19) : AC(14)
Additional Keywords : Metformin Alternatives : CK(19) : AC(6), Natural Substances Versus Drugs : CK(1698) : AC(302)

Curcumin, berberine, catechin, quercetin and rutin had binding ability towards alpha-amylase and alpha-glucosidase.

Pubmed Data : Biofactors. 2015 Jul 7. Epub 2015 Jul 7. PMID: 26154585
Article Published Date : Jul 06, 2015
Authors : Chien-Hung Jhong, Jirawat Riyaphan, Shih-Hung Lin, Yi-Chen Chia, Ching-Feng Weng
Study Type : In Vitro Study
Additional Links
Substances : Berberine : CK(325) : AC(166), Catechin : CK(512) : AC(169), Curcumin : CK(4803) : AC(2175), Quercetin : CK(568) : AC(250), Rutin : CK(126) : AC(48)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Hyperglycemia : CK(539) : AC(130)
Pharmacological Actions : Alpha-amylase inhibitor : CK(34) : AC(20), Alpha-glucosidase inhibitor : CK(52) : AC(37)
Additional Keywords : Natural Substances Versus Drugs : CK(1698) : AC(302)

Tetrahydrocurcumin displays antihyperlipidaemic effect in addition to its antidiabetic effect in type 2 diabetic rats.

Pubmed Data : Basic Clin Pharmacol Toxicol. 2006 Aug;99(2):122-7. PMID: 16918712
Article Published Date : Aug 01, 2006
Authors : Pidaran Murugan, Leelavinothan Pari
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Tetrahydrocurcumin : CK(66) : AC(30)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Oxidative Stress : CK(3871) : AC(1382)
Pharmacological Actions : Hypolipidemic : CK(1288) : AC(265)

Tetrahydrocurcumin increases the number of total cellular insulin binding sites resulting in a significant increase in plasma insulin.

Pubmed Data : J Biosci. 2008 Mar;33(1):63-72. PMID: 18376071
Article Published Date : Mar 01, 2008
Authors : Pidaran Murugan, Leelavinothan Pari, Chippada Appa Rao
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Tetrahydrocurcumin : CK(66) : AC(30)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Insulin Resistance : CK(1683) : AC(346)

Tetrahydrocurcumin normalizes blood glucose and causes a marked improvement of altered carbohydrate metabolic enzymes in diabetic animals.

Pubmed Data : J Basic Clin Physiol Pharmacol. 2005;16(4):257-74. PMID: 16438392
Article Published Date : Jan 01, 2005
Authors : Leelavinothan Pari, Pidaran Murugan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Tetrahydrocurcumin : CK(66) : AC(30)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624)
Pharmacological Actions : Hypoglycemic Agents : CK(1446) : AC(342)

Treatment with combinatorial extract of curcumin presented a significantly better therapeutic potential when compared with curcumin alone.

Pubmed Data : J Complement Integr Med. 2016 Jun 25. Epub 2016 Jun 25. PMID: 27343476
Article Published Date : Jun 24, 2016
Authors : Ginpreet Kaur, Mihir Invally, Meena Chintamaneni
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Piperine : CK(114) : AC(60), Quercetin : CK(568) : AC(250)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624)
Pharmacological Actions : Hypoglycemic Agents : CK(1446) : AC(342)
Additional Keywords : Natural Substance Synergy : CK(540) : AC(249), Natural Substances Versus Drugs : CK(1698) : AC(302)

Turmeric and curcumin have anti-diabetic actions.

Pubmed Data : Plant Foods Hum Nutr. 2002;57(1):41-52. PMID: 11855620
Article Published Date : Jan 01, 2002
Authors : N Arun, N Nalini
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes: Glycation/A1C : CK(210) : AC(33), Diabetes Mellitus: Type 1 : CK(1130) : AC(301), Diabetes Mellitus: Type 2 : CK(3572) : AC(624)

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