Focused Research Topics Curcumin & Liver Cancer

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Curcumin Curcumin: Lipidated

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66 Research Articles in Total

Curcumin encapsulation in geranium oil microemulsion elevates its antibacterial, antioxidant, anti-inflammatory, and anticancer activities.

Pubmed Data : ACS Omega. 2024 Feb 6 ;9(5):5624-5636. Epub 2024 Jan 23. PMID: 38343911
Article Published Date : Feb 05, 2024
Authors : Shahzadi Filza Hassan, Sajid Asghar, Ikram Ullah Khan, Rabia Munir, Syed Haroon Khalid
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Geranium : CK(88) : AC(36)
Diseases : Escherichia coli Infections : CK(603) : AC(450), Inflammation : CK(16108) : AC(5498), Liver Cancer : CK(3119) : AC(1641), Staphylococcus aureus infection : CK(776) : AC(576)
Pharmacological Actions : Anti-Bacterial Agents : CK(4228) : AC(1989), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

The synergistic effects between curcumin and MSCs therapy may hold great promise as a curative combination for HCC.

Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(18):8271-9. PMID: 26745072
Article Published Date : Dec 31, 2014
Authors : Ola M Tork, Eman F Khaleel, Omnia M Abdelmaqsoud
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

An isocaloric carbohydrate restriction diet and natural AMPK activating agents induce synergistic anticancer effects.

Pubmed Data : Eur J Cancer Prev. 2015 Mar 19. Epub 2015 Mar 19. PMID: 25747515
Article Published Date : Mar 18, 2015
Authors : Jong Doo Lee, Min-Ah Choi, Simon Weonsang Ro, Woo Ick Yang, Arthur E H Cho, Hye-Lim Ju, Sinhwa Baek, Sook In Chung, Won Jun Kang, Mijin Yun, Jeon Han Park
Study Type : In Vitro Study, Transgenic Animal Study
Additional Links
Substances : Catechin : CK(965) : AC(313), Curcumin : CK(7239) : AC(3319), Quercetin : CK(1876) : AC(855), Resveratrol : CK(3228) : AC(1513)
Diseases : Liver Cancer : CK(3119) : AC(1641), Melanoma : CK(924) : AC(552)
Therapeutic Actions : Dietary Modification: Low Carbohydrate : CK(34) : AC(5)
Pharmacological Actions : AMP-activated protein kinase modulation : CK(6) : AC(4), Antiproliferative : CK(10001) : AC(7491), Chemopreventive : CK(6580) : AC(2166), Interleukin-6 Downregulation : CK(9337) : AC(3613), SIRT1 Activator : CK(382) : AC(190)
Additional Keywords : Diet Induced Tumor Suppression : CK(2) : AC(1)

Curcumin inhibits chemically-induced liver cancer.

Pubmed Data : Food Chem Toxicol. 2000 Nov;38(11):991-5. PMID: 11038236
Article Published Date : Nov 01, 2000
Authors : S E Chuang, A L Cheng, J K Lin, M L Kuo
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Chemopreventive : CK(6580) : AC(2166), Hepatoprotective : CK(8989) : AC(3831), NF-kappaB Inhibitor : CK(5952) : AC(3464), Tumor Suppressor Protein p53 Upregulation : CK(755) : AC(554)

Curcumin sensitizes human HCC cells to radiation via the suppression of radiation-induced NF-κB activity.

Pubmed Data : Biomed Res Int. 2015 ;2015:363671. Epub 2015 Oct 11. PMID: 26539482
Article Published Date : Dec 31, 2014
Authors : Fei-Ting Hsu, Yu-Chang Liu, Tsu-Te Liu, Jeng-Jong Hwang
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : NF-kappaB Inhibitor : CK(5952) : AC(3464), Radiosensitizer : CK(372) : AC(247)

Micellar curcumin in combination with cisplatin can be a promising strategy for treatment of pediatric hepatocellular carcinoma.

Pubmed Data : Oncotarget. 2015 Oct 19. Epub 2015 Oct 19. PMID: 26515460
Article Published Date : Oct 18, 2015
Authors : Nicola Bortel, Sorin Armeanu-Ebinger, Evi Schmid, Bettina Kirchner, Jan Frank, Alexa Kocher, Christina Schiborr, Steven Warmann, Jörg Fuchs, Verena Ellerkamp
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379), NF-kappaB Inhibitor : CK(5952) : AC(3464), Wnt/β-catenin signaling pathway modulation : CK(330) : AC(224)
Additional Keywords : Chemotherapeutic Synergy: Cisplatin : CK(430) : AC(339)

Curcumin inhibits liver cancer cell invasiveness.

Pubmed Data : Comp Biochem Physiol B Biochem Mol Biol. 2000 Oct;127(2):213-22. PMID: 9663426
Article Published Date : Oct 01, 2000
Authors : L I Lin, Y F Ke, Y C Ko, J K Lin
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cancer Metastasis : CK(961) : AC(542), Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Anti-metastatic : CK(2870) : AC(2182), Antineoplastic Agents : CK(2235) : AC(1468), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(1141) : AC(720)

Curcumin may be a viable anticancer agent in the treatment of HCC.

Pubmed Data : Mol Med Rep. 2014 Nov ;10(5):2505-10. Epub 2014 Sep 9. PMID: 25216080
Article Published Date : Oct 31, 2014
Authors : Wanxing Duan, Yuanhong Chang, Rong Li, Qinhong Xu, Jianjun Lei, Caiqiao Yin, Ting Li, Yanzhao Wu, Qingyong Ma, Xuqi Li
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Hypoxia : CK(436) : AC(244), Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Anti-metastatic : CK(2870) : AC(2182), Antineoplastic Agents : CK(2235) : AC(1468), Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379)

Curcumin modulates hepatocellular carcinoma by reducing UNC119 expression.

Pubmed Data : J Environ Pathol Toxicol Oncol. 2019 ;38(3):195-203. PMID: 31679307
Article Published Date : Dec 31, 2018
Authors : Zhenjiang Zhao, Anshoo Malhotra, Wu Yuan Seng
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cancer Metastasis : CK(961) : AC(542), Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Anti-metastatic : CK(2870) : AC(2182), Antiproliferative : CK(10001) : AC(7491)

Curcumin suppressed phthalate-induced cell migration, invasion and epithelial-mesenchymal transition, decreased the proportion of CSC-like cells.

Pubmed Data : J Agric Food Chem. 2015 Nov 20. Epub 2015 Nov 20. PMID: 26585812
Article Published Date : Nov 19, 2015
Authors : Cheng-Fang Tsai, Tsung-Hua Hsieh, Jau-Nan Lee, Chia-Yi Hsu, Yu-Chih Wang, Kung-Kai Kuo, Hua-Lin Wu, Chien-Chih Chiu, Eing-Mei Tsai, Po-Lin Kuo
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641), Liver Cancer: Metastatic : CK(23) : AC(10), Phthalate Toxicity : CK(1232) : AC(238)
Pharmacological Actions : Anti-metastatic : CK(2870) : AC(2182)
Additional Keywords : Cancer Stem Cells : CK(501) : AC(365)
Problem Substances : Phthalates : CK(1705) : AC(331)
Adverse Pharmacological Actions : Carcinogenic : CK(1052) : AC(159)

High dose of curcumin might be an effective anti-angiogenic drug in the treatment against tumor.

Pubmed Data : Mol Pharmacol.2007 Dec;72(6):1508-21. Epub 2007 Sep 14. PMID: 16151260
Article Published Date : Dec 01, 2007
Authors : P Yoysungnoen, P Wirachwong, P Bhattarakosol, H Niimi, S Patumraj
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cancer Metastasis : CK(961) : AC(542), Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Anti-Angiogenic : CK(421) : AC(284), Anti-metastatic : CK(2870) : AC(2182)

"Curcumin nanoparticles improve the physicochemical properties of curcumin and effectively enhance its antioxidant and antihepatoma activities."

Pubmed Data : J Agric Food Chem. 2010 Jun 23 ;58(12):7376-82. PMID: 20486686
Article Published Date : Jun 23, 2010
Authors : Feng-Lin Yen, Tzu-Hui Wu, Cheng-Wei Tzeng, Liang-Tzung Lin, Chun-Ching Lin
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Hepatoma : CK(37) : AC(32), Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Antineoplastic Agents : CK(2235) : AC(1468), Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Nanoencapsulated Curcumin : CK(5) : AC(3)

Curcumin and photobiomodulation in chronic viral hepatitis and hepatocellular carcinoma.

Pubmed Data : Int J Mol Sci. 2020 Sep 28 ;21(19). Epub 2020 Sep 28. PMID: 32998270
Article Published Date : Sep 27, 2020
Authors : Laura Marinela Ailioaie, Gerhard Litscher
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Hepatitis B : CK(422) : AC(114), Liver Cancer : CK(3119) : AC(1641), Liver Cirrhosis : CK(919) : AC(230)
Therapeutic Actions : Photobiomodulation : CK(17459) : AC(3331)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Antiviral Agents : CK(3095) : AC(1702)

An extract of turmeric and its phenolic constituents inhibit the growth of human hepatoma cell line (HepG2).

Pubmed Data : Acta Pharm. 2016 Sep 1 ;66(3):387-398. PMID: 27383887
Article Published Date : Aug 31, 2016
Authors : Ezzat Abdel-Lateef, Faten Mahmoud, Olfat Hammam, Eman El-Ahwany, Eman El-Wakil, Sherihan Kandil, Hoda Abu Taleb, Mortada El-Sayed, Hanaa Hassenein
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Curcuminoids : CK(7851) : AC(3498), Turmeric : CK(9427) : AC(3904)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Design of turmeric rhizome extract nano-formula for delivery to cancer cells.

Pubmed Data : Molecules. 2022 Jan 28 ;27(3). Epub 2022 Jan 28. PMID: 35164159
Article Published Date : Jan 27, 2022
Authors : Sakchai Auychaipornlert, Pojawon Prayurnprohm Lawanprasert, Suchada Piriyaprasarth, Pongtip Sithisarn, Supachoke Mangmool
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Cytotoxic : CK(276) : AC(234)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Embelin and curcumin have a chemopreventive effect against chemically-induced liver cancer.

Pubmed Data : Fitoterapia. 2005 Sep;76(6):549-55. PMID: 16009505
Article Published Date : Sep 01, 2005
Authors : M Sreepriya, Geetha Bali
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Embelia ribes : CK(16) : AC(8)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Chemopreventive : CK(6580) : AC(2166)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Anti-cancer effect of nano-encapsulated boswellic acids, curcumin and naringenin against HepG-2 cell line.

Pubmed Data : BMC Complement Med Ther. 2023 Jul 29 ;23(1):270. Epub 2023 Jul 29. PMID: 37516826
Article Published Date : Jul 28, 2023
Authors : Sally Elnawasany, Yusuf A Haggag, Shahinaz M Shalaby, Nema A Soliman, Amira A El Saadany, Marwa A A Ibrahim, Farid Badria
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Frankincense : CK(1021) : AC(260), Naringenin : CK(704) : AC(394)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Antiproliferative : CK(10001) : AC(7491)

Astragaloside IV and curcumin alone and in combination significantly reduced mean tumor weight compared to vehicle control.

Pubmed Data : Anticancer Res. 2017 02 ;37(2):465-473. PMID: 28179291
Article Published Date : Dec 31, 2016
Authors : Shuo Zhang, Decai Tang, Wenhua Zang, Gang Yin, Jianguo Dai, Y U Sun, Zhijian Yang, Robert M Hoffman, Xiuxia Guo
Study Type : Animal Study
Additional Links
Substances : Astragaloside : CK(843) : AC(453), Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Antiproliferative : CK(10001) : AC(7491), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(944) : AC(588), MicroRNA modulator : CK(1560) : AC(897), Vascular Endothelial Growth Factor Inhibitors : CK(611) : AC(335)
Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

Both curcumin and carvacrol showed a great efficacy against hepatocellular carcinoma.

Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(12):4949-54. PMID: 26163620
Article Published Date : Dec 31, 2014
Authors : Hanaa H Ahmed, Wafaa Gh Shousha, Aziza B Shalby, Hatem A El-Mezayen, Nora N Ismaiel, Nadia S Mahmoud
Study Type : Animal Study
Additional Links
Substances : Carvacrol : CK(303) : AC(174), Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Angiogenesis Inhibitors : CK(724) : AC(481), Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379)
Additional Keywords : Gene Expression Regulation : CK(1401) : AC(623)

Curcumin and berberine co-loaded liposomes for anti-hepatocellular carcinoma therapy.

Pubmed Data : Front Pharmacol. 2022 ;13:961788. Epub 2022 Sep 14. PMID: 36188590
Article Published Date : Dec 31, 2021
Authors : Jingliang Wu, Cuiping Qi, Hao Wang, Qing Wang, Jingui Sun, Jinping Dong, Guohua Yu, Zhiqin Gao, Bo Zhang, Guixiang Tian
Study Type : In Vitro Study
Additional Links
Substances : Berberine : CK(2483) : AC(1079), Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379)

Curcumin decreases survival of liver and breast cancer cells.

Pubmed Data : Strahlenther Onkol. 2011 Jul ;187(7):393-400. Epub 2011 Jun 27. PMID: 21713389
Article Published Date : Jul 01, 2011
Authors : Mareike Ströfer, Wolfgang Jelkmann, Reinhard Depping
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Breast Cancer : CK(8297) : AC(3043), Hypoxia : CK(436) : AC(244), Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379), Radiosensitizer : CK(372) : AC(247)

Curcumin has anticancer activity in human liver cancer cell lines.

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2010 Feb;35(4):485-8. PMID: 20450049
Article Published Date : Feb 01, 2010
Authors : Weizhang Wang, Biyu Zhang, Hongyuan Chen, Li Zhang
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379), Cell cycle arrest : CK(2120) : AC(1715)

Curcumin inhibits liver cancer cell gowth.

Pubmed Data : Zhonghua Gan Zang Bing Za Zhi. 2002 Dec;10(6):449-51. PMID: 12502450
Article Published Date : Dec 01, 2002
Authors : Hongyuan Li, Yi Che, Weixue Tang
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Antineoplastic Agents : CK(2235) : AC(1468), Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379), Cell cycle arrest : CK(2120) : AC(1715)

Curcumin inhibits the growth of liver cancer.

Pubmed Data : Oncol Lett. 2021 Apr ;21(4):286. Epub 2021 Feb 12. PMID: 33732362
Article Published Date : Mar 31, 2021
Authors : Sha Tian, Liu Liao, Qing Zhou, Xiaodi Huang, Piao Zheng, Yinmei Guo, Tianhao Deng, Xuefei Tian
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Antiproliferative : CK(10001) : AC(7491)

Curcumin, thymoquinone, and 3, 3'-diindolylmethane combinations attenuate lung and liver cancers progression.

Pubmed Data : Front Pharmacol. 2022 ;13:936996. Epub 2022 Jun 29. PMID: 35847018
Article Published Date : Dec 31, 2021
Authors : Amna A Saddiq, Ali H El-Far, Shymaa Abdullah Mohamed Abdullah, Kavitha Godugu, Omar A Almaghrabi, Shaker A Mousa
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Thymoquinone : CK(1178) : AC(692)
Diseases : Liver Cancer : CK(3119) : AC(1641), Lung Cancer : CK(3063) : AC(1429)
Pharmacological Actions : Angiogenesis Inhibitors : CK(724) : AC(481), Antiproliferative : CK(10001) : AC(7491)

Inhibition of hepatocellular carcinoma growth via modulation of the miR-221/SOX11 axis by curcumin and berberine.

Pubmed Data : PeerJ. 2023 ;11:e16593. Epub 2023 Dec 7. PMID: 38084140
Article Published Date : Dec 31, 2022
Authors : Sheng Li, Xiaoliang Cai, Liang Chen, Manbian Lin, Ziqi Zhu, Huihuang Xiao, Pingping Nie, Quanwen Chen, Xiaoyu Yang
Study Type : In Vitro Study
Additional Links
Substances : Berberine : CK(2483) : AC(1079), Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379)

Phototherapy strongly enhances the anticancer properties of curcumin in pediatric solid liver tumors in vitro.

Pubmed Data : Anticancer Res. 2016 Jul ;36(7):3363-72. PMID: 27354595
Article Published Date : Jun 30, 2016
Authors : Verena Ellerkamp, Nicola Bortel, Evi Schmid, Bettina Kirchner, Sorin Armeanu-Ebinger, Jörg Fuchs
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Therapeutic Actions : Integrative Medicine : CK(501) : AC(69), Photodynamic therapy : CK(381) : AC(103)
Pharmacological Actions : Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379)

Targeted delivery of curcumin and CM11 peptide against hepatocellular carcinoma cells.

Pubmed Data : Amino Acids. 2025 Jan 25 ;57(1):12. Epub 2025 Jan 25. PMID: 39862295
Article Published Date : Jan 24, 2025
Authors : Danial Rahmani, Ramezan Ali Taheri, Mehrdad Moosazadeh Moghaddam
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Antiproliferative : CK(10001) : AC(7491)

The combination of Curcumin and Berberine is a novel strategy that has potential in the treatment of cancer patients.

Pubmed Data : Biomed Res Int. 2015 ;2015:354614. Epub 2015 Jun 29. PMID: 26247019
Article Published Date : Dec 31, 2014
Authors : Acharya Balakrishna, M Hemanth Kumar
Study Type : In Vitro Study
Additional Links
Substances : Berberine : CK(2483) : AC(1079), Curcumin : CK(7239) : AC(3319)
Diseases : Acute T cell Leukemias : CK(48) : AC(45), Breast Cancer : CK(8297) : AC(3043), Liver Cancer : CK(3119) : AC(1641), Lung Cancer : CK(3063) : AC(1429)
Pharmacological Actions : Antiproliferative : CK(10001) : AC(7491)
Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

Cisplatin and curcumin co-loaded nano-liposomes for the treatment of hepatocellular carcinoma.

Pubmed Data : Int J Pharm. 2018 Jul 10 ;545(1-2):261-273. Epub 2018 May 3. PMID: 29730175
Article Published Date : Jul 09, 2018
Authors : Yao Cheng, Pengxuan Zhao, Shuangping Wu, Tan Yang, Yan Chen, Xiaojuan Zhang, Chuanchuan He, Chao Zheng, Kelin Li, Xiang Ma, Guangya Xiang
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Apoptotic : CK(9585) : AC(7379)
Additional Keywords : Chemotherapeutic Synergy: Cisplatin : CK(430) : AC(339)

Cucurbitacin B in the combination with curcumin could serve as a novel, promising approach for human hepatoma.

Pubmed Data : Eur J Pharmacol. 2015 Oct 6. Epub 2015 Oct 6. PMID: 26452516
Article Published Date : Oct 05, 2015
Authors : Yuqi Sun, Jie Zhang, Jiaying Zhou, Ziyuan Huang, Haiyang Hu, Mingxi Qiao, Xiuli Zhao, Dawei Chen
Study Type : Human In Vitro
Additional Links
Substances : Cucurbitacin B : CK(178) : AC(119), Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Apoptotic : CK(9585) : AC(7379)
Additional Keywords : Multidrug Resistance : CK(26) : AC(17), Natural Substance Synergy : CK(1400) : AC(669)

Curcumin and resveratrol-co-loaded nanoparticles in synergistic treatment of hepatocellular carcinoma.

Pubmed Data : J Nanobiotechnology. 2022 Jul 20 ;20(1):339. Epub 2022 Jul 20. PMID: 35858935
Article Published Date : Jul 19, 2022
Authors : Yongshun Zheng, Ran Jia, Jun Li, Xiaohe Tian, Yeben Qian
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Resveratrol : CK(3228) : AC(1513)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Apoptotic : CK(9585) : AC(7379)
Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

Curcumin exhibits anti-liver cancer activity.

Pubmed Data : Int J Pharm. 2010 Nov 15;400(1-2):211-20. Epub 2010 Sep 8. PMID: 20813175
Article Published Date : Nov 15, 2010
Authors : Jinghua Duan, Yangde Zhang, Shiwei Han, Yuxiang Chen, Bo Li, Mingmei Liao, Wei Chen, Xingming Deng, Jinfeng Zhao, Boyun Huang
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Anti-Angiogenic : CK(421) : AC(284), Apoptotic : CK(9585) : AC(7379)

Curcumin induces HspG2 cell death by increasing apoptosis and pyroptosis.

Pubmed Data : In Vivo. 2021 Jan-Feb;35(1):249-257. PMID: 33402471
Article Published Date : Dec 31, 2020
Authors : Wan-Feng Liang, Yi-Xi Gong, Hai-Feng Li, Fu-Liang Sun, Wei-Long Li, Dong-Qin Chen, Dan-Ping Xie, Chen-Xi Ren, Xiao-Yu Guo, Zi-Yi Wang, Taeho Kwon, Hu-Nan Sun
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Apoptotic : CK(9585) : AC(7379)

Curcumin induces programmed cell death in a variety of cancer cell lines.

Pubmed Data : Nutr Cancer. 1996;26(1):111-20. PMID: 8844727
Article Published Date : Jan 01, 1996
Authors : M C Jiang, H F Yang-Yen, J J Yen, J K Lin
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Colon Cancer : CK(1920) : AC(1203), Liver Cancer : CK(3119) : AC(1641), Sarcoma : CK(117) : AC(73)
Pharmacological Actions : Apoptotic : CK(9585) : AC(7379)

Curcumin induces programmed cell death in human liver cancer cells.

Pubmed Data : Food Chem Toxicol. 2006 Jun;44(6):810-8. Epub 2005 Dec 5. PMID: 16537656
Article Published Date : Jun 01, 2006
Authors : Jun Cao, Li Jia, Hui-Min Zhou, Yong Liu, Lai-Fu Zhong
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : DNA damage : CK(2301) : AC(842), Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Apoptotic : CK(9585) : AC(7379)

Curcumin induces programmed cell death in human liver cancer cells.

Pubmed Data : Oncogene. 1996 Aug 1;13(3):609-16. PMID: 8760302
Article Published Date : Aug 01, 1996
Authors : M C Jiang, H F Yang-Yen, J K Lin, J J Yen
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Antineoplastic Agents : CK(2235) : AC(1468), Apoptotic : CK(9585) : AC(7379), Bcl-2 protein down-regulation : CK(711) : AC(529), Cell cycle arrest : CK(2120) : AC(1715), Tumor Suppressor Protein p53 Upregulation : CK(755) : AC(554)

Curcumin inhibits the proliferation of human liver cancer cells.

Pubmed Data : Int J Mol Med. 2010 Nov;26(5):673-8. PMID: 20878089
Article Published Date : Nov 01, 2010
Authors : Chun-Yuan Cheng, Yi-Hsiang Lin, Chin-Cheng Su
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Apoptotic : CK(9585) : AC(7379)

Synergistic therapy with celastrol-curcumin multifunctional nanomedicine: Anti-hepatocellular carcinoma and reduced hepatotoxicity.

Pubmed Data : Int J Pharm. 2025 Feb 25 ;671:125289. Epub 2025 Jan 27. PMID: 39880142
Article Published Date : Feb 24, 2025
Authors : Yushi Liu, Jiawen Song, Yurou Guo, Sihui Li, Minghao Yuan, Jiamei Tang, Yulu Wang, Meifeng Li, Yiping Guo, Li Guo
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Celastrol : CK(213) : AC(133), Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Apoptotic : CK(9585) : AC(7379), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

Curcuminoids can inhibit tumor promotion caused by iron in T51B cells.

Pubmed Data : Nutr Cancer. 2017 Jan 27:1-9. Epub 2017 Jan 27. PMID: 28129008
Article Published Date : Jan 26, 2017
Authors : Donald J Messner, Todd Robinson, Kris V Kowdley
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Curcuminoids : CK(7851) : AC(3498), Turmeric : CK(9427) : AC(3904)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Anticarcinogenic Agents : CK(2152) : AC(1018), Chemopreventive : CK(6580) : AC(2166)

Curcumin suppresses prevents pre-cancerous changes in the liver of animals.

Pubmed Data : Nutr Cancer. 2003;45(1):53-9. PMID: 12791505
Article Published Date : Jan 01, 2003
Authors : Yogeshwer Shukla, Annu Arora
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Antineoplastic Agents : CK(2235) : AC(1468), Hepatoprotective : CK(8989) : AC(3831)

"Curcumin and Liver Cancer: A Review."

Pubmed Data : Curr Pharm Biotechnol. 2011 Apr 5. Epub 2011 Apr 5. PMID: 21466422
Article Published Date : Apr 05, 2011
Authors : Altaf S Darvesh, Bharat B Aggarwal, Anupam Bishayee
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)

An overview of natural plant products in the treatment of hepatocellular carcinoma.

Pubmed Data : Anticancer Agents Med Chem. 2018 Jun 3. Epub 2018 Jun 3. PMID: 29866017
Article Published Date : Jun 02, 2018
Authors : Divya Rawat, Somi Shrivastava, Rayees Ahmad Naik, Saurabh Kumar Chhonker, Aditi Mehrotra, Raj Kumar Koiri
Study Type : Review
Additional Links
Substances : Caffeine : CK(478) : AC(89), Curcumin : CK(7239) : AC(3319), Emodin : CK(405) : AC(258), Lycopene : CK(1267) : AC(372), Phloretin : CK(232) : AC(137), Quercetin : CK(1876) : AC(855), Resveratrol : CK(3228) : AC(1513), Silibinin : CK(460) : AC(231), Urolithin A : CK(247) : AC(128)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Chemopreventive : CK(6580) : AC(2166)

Curcumin and tetrahydrocurcumin exhibit anti-cancer properties in liver cancer.

Pubmed Data : World J Gastroenterol. 2008 Apr 7;14(13):2003-9. PMID: 18395899
Article Published Date : Apr 07, 2008
Authors : Pornprom Yoysungnoen, Ponthip Wirachwong, Chatchawan Changtam, Apichart Suksamrarn, Suthiluk Patumraj
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Anti-Angiogenic : CK(421) : AC(284), Antineoplastic Agents : CK(2235) : AC(1468)

Curcumin has been used to successfully treat infantile hemangioendothelioma of the liver.

Pubmed Data : Pediatr Blood Cancer. 2010 Aug;55(2):377-9. PMID: 20582974
Article Published Date : Aug 01, 2010
Authors : Lewis A Hassell, Le Dinh Roanh
Study Type : Human: Case Report
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Hemangioendothelioma : CK(5) : AC(2), Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Antineoplastic Agents : CK(2235) : AC(1468)

Curcumin inhibits aflatoxin-associated DNA adduct formation associated with liver carcinogenesis.

Pubmed Data : Chem Biol Interact. 1996 Mar 8;100(1):41-51. PMID: 8599854
Article Published Date : Mar 08, 1996
Authors : P F Firozi, V S Aboobaker, R K Bhattacharya
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aflatoxicosis : CK(301) : AC(109), DNA damage : CK(2301) : AC(842), Liver Cancer : CK(3119) : AC(1641), Liver Damage: Aflatoxin-Induced : CK(104) : AC(48)

Curcumin inhibits hypoxia-induced angiogenesis associated wtih tumor progression.

Pubmed Data : Oncol Rep. 2006 Jun;15(6):1557-62. PMID: 16685395
Article Published Date : Jun 01, 2006
Authors : Moon-Kyoung Bae, Se-Hee Kim, Joo-Won Jeong, You Mie Lee, Hae-Sun Kim, Su-Ryun Kim, Il Yun, Soo-Kyung Bae, Kyu-Won Kim
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cancer Metastasis : CK(961) : AC(542), Hypoxia : CK(436) : AC(244), Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Anti-Angiogenic : CK(421) : AC(284), Vascular Endothelial Growth Factor A Inhibitor : CK(231) : AC(127)

Curcumin inhibits liver tumor angiogenesis and growth.

Pubmed Data : Clin Hemorheol Microcirc. 2006;34(1-2):109-15. PMID: 16543625
Article Published Date : Jan 01, 2006
Authors : Pornprom Yoysungnoen, Porntip Wirachwong, Pavaphon Bhattarakosol, Hideyuki Niimi, Suthiluk Patumraj
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cancer Metastasis : CK(961) : AC(542), Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Anti-Angiogenic : CK(421) : AC(284), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Vascular Endothelial Growth Factor A Inhibitor : CK(231) : AC(127)

Curcumin prevents chemically-induced liver cancer.

Pubmed Data : Cancer Lett. 2001 Jun 10;167(1):33-8. PMID: 11323096
Article Published Date : Jun 10, 2001
Authors : S Busquets, N Carbó, V Almendro, M T Quiles, F J López-Soriano, J M Argilés
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Antineoplastic Agents : CK(2235) : AC(1468), Chemopreventive : CK(6580) : AC(2166)

Curcumin prevents chemically-induced liver cancer.

Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):439-42. Epub 2006 Dec 15. PMID: 10657978
Article Published Date : Mar 30, 2007
Authors : S E Chuang, M L Kuo, C H Hsu, C R Chen, J K Lin, G M Lai, C Y Hsieh, A L Cheng
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Anticarcinogenic Agents : CK(2152) : AC(1018), Chemopreventive : CK(6580) : AC(2166)

Curcumin prevents chemically-induced lung and liver tumorigenesis.

Pubmed Data : In Vivo. 2008 Nov-Dec;22(6):781-5. PMID: 19181006
Article Published Date : Nov 01, 2008
Authors : An-Cheng Huang, Shuw-Yuan Lin, Chin-Cheng Su, Song-Shei Lin, Chin-Chin Ho, Te-Chun Hsia, Tsan-Hung Chiu, Chun-Shu Yu, Siu-Wan Ip, Tsung-Ping Lin, Jing-Gung Chung
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641), Lung Cancer : CK(3063) : AC(1429)
Pharmacological Actions : Antineoplastic Agents : CK(2235) : AC(1468), Chemopreventive : CK(6580) : AC(2166)

Curcumin prevents liver cancer metastasis in an animal model.

Pubmed Data : Oncology. 2003;65(3):250-8. PMID: 14657599
Article Published Date : Jan 01, 2003
Authors : Yasukata Ohashi, Yasunori Tsuchiya, Keiichi Koizumi, Hiroaki Sakurai, Ikuo Saiki
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cancer Metastasis : CK(961) : AC(542), Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Antineoplastic Agents : CK(2235) : AC(1468)

Curcumin, piperine and taurine combination enhances the efficacy of transarterial chemoembolization therapy.

Pubmed Data : Asian Pac J Cancer Prev. 2024 May 1 ;25(5):1589-1598. Epub 2024 May 1. PMID: 38809630
Article Published Date : Apr 30, 2024
Authors : Reham Abd El Rahiem, Sherif Abdelaziz Ibrahim, Heba Effat, Motawa E El-Houseini, Randa A Osman, Amr Abdelraouf, Emad M Elzayat
Study Type : Human In Vitro
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Piperine : CK(600) : AC(258)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Chemotherapeutic : CK(4390) : AC(1635)

Curcumin-loaded mesoporous silica nanoparticles markedly enhanced cytotoxicity in hepatocellular carcinoma cells.

Pubmed Data : Int J Mol Sci. 2019 Jun 14 ;20(12). Epub 2019 Jun 14. PMID: 31207976
Article Published Date : Jun 13, 2019
Authors : Zwe-Ling Kong, Hsiang-Ping Kuo, Athira Johnson, Li-Cyuan Wu, Ke Liang B Chang
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Cytotoxic : CK(276) : AC(234)

DNC potentially can induce DNA hypomethylation and re-expression of silenced tumor suppressor genes in HCC.

Pubmed Data : Phytomedicine. 2015 Sep 15 ;22(10):961-7. Epub 2015 Jul 14. PMID: 26321746
Article Published Date : Sep 14, 2015
Authors : Mina Zamani, Majid Sadeghizadeh, Mehrdad Behmanesh, Farhood Najafi
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : MicroRNA modulator : CK(1560) : AC(897)
Additional Keywords : Epigenetic Modification In Cancer : CK(189) : AC(126), Hypomethylation : CK(35) : AC(6), Reactivation Of Tumor Suppressor Gene : CK(19) : AC(15)

Galactosylated alginate-curcumin conjugate could be used for targeted delivery of curcumin to HepG2 cells.

Pubmed Data : Int J Biol Macromol. 2016 Jan 13. Epub 2016 Jan 13. PMID: 26774374
Article Published Date : Jan 12, 2016
Authors : Sarika P R, Nirmala Rachel James, Anil Kumar P R, Deepa K Raj
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Cytotoxic : CK(276) : AC(234)
Additional Keywords : Selective Cytotoxicity : CK(274) : AC(201)

Liposomal curcumin inhibits hypoxia-induced angiogenesis.

Pubmed Data : Onco Targets Ther. 2015 ;8:2601-11. Epub 2015 Sep 15. PMID: 26451117
Article Published Date : Dec 31, 2014
Authors : Feng Dai, Xiuming Zhang, Wenrong Shen, Jun Chen, Liucheng Liu, Gejun Gao
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Angiogenesis Inhibitors : CK(724) : AC(481), Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor : CK(363) : AC(237)

Nanocapsulated curcumin acts as an oral chemopreventive formulation against chemically-induced hepatocellular carcinoma in rat.

Pubmed Data : Chem Biol Interact. 2011 Dec 16. Epub 2011 Dec 16. PMID: 22197969
Article Published Date : Dec 16, 2011
Authors : Debasree Ghosh, Somsubhra Thakur Choudhury, Swarupa Ghosh, Ardhendu K Mandal, Sibani Sarkar, Aparajita Ghosh, Krishna Das Saha, Nirmalendu Das
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Liver Cancer : CK(3119) : AC(1641)
Additional Keywords : Nanoencapsulated Curcumin : CK(5) : AC(3)

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