Curcumin & Antioxidants Focused Research

Authors : Badreldin H Ali, Suhail Al-Salam, Yousuf Al Suleimani, Jamila Al Kalbani, Shadia Al Bahlani, Mohammed Ashique, Priyadarsini Manoj, Buthaina Al Zhili, Nadia Al Abri, Heba T Naser, Javed Yasin, Abderrahim Nemmar, Mohamed Al Za'abi, Christina Hartmann, Nicole Schupp

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chronic Kidney Disease (CKD) : CK(147) : AC(23)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Nrf2 activation : CK(177) : AC(86)

Curcumin had protective effects against cerebral ischemia/reperfusion injury in animals.

Pubmed Data : Microvasc Res. 2015 Dec 11. Epub 2015 Dec 11. PMID: 26686249

Article Published Date : Dec 10, 2015

Authors : Wei Li, Nijasri C Suwanwela, Suthiluk Patumraj

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Edema : CK(49) : AC(13), Cerebral Ischemia : CK(229) : AC(77)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099), NF-kappaB Inhibitor : CK(1114) : AC(694), Nrf2 activation : CK(177) : AC(86)

Curcumin has a promising role as a cardioprotective agent against palmitate and high fat diet mediated cardiac dysfunction.

Pubmed Data : J Mol Cell Cardiol. 2015 Feb ;79:1-12. Epub 2014 Oct 16. PMID: 25444713

Article Published Date : Jan 31, 2015

Authors : Chunlai Zeng, Peng Zhong, Yunjie Zhao, Karvannan Kanchana, Yali Zhang, Zia A Khan, Subrata Chakrabarti, Lianpin Wu, Jingying Wang, Guang Liang

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Circulating Free Fatty Acids: Elevated : CK(3) : AC(2), High Fat Diet : CK(212) : AC(103), Obesity : CK(2443) : AC(521)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Cardioprotective : CK(1596) : AC(409), NF-kappaB Inhibitor : CK(1114) : AC(694), Nrf2 activation : CK(177) : AC(86)

Curcumin has a protective role in cardiovascular diseases.

Pubmed Data : Int J Cardiol. 2009 Apr 3;133(2):145-51. Epub 2009 Feb 23. PMID: 19233493

Article Published Date : Apr 03, 2009

Authors : Wanwarang Wongcharoen, Arintaya Phrommintikul

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cardiovascular Diseases : CK(7342) : AC(916)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Cardiovascular Agents : CK(160) : AC(24)

Curcumin has potential for treatment of heart disease in patients with established CKD by attenuating oxidative stress-related cardiac remodeling and mitochondrial dysfunction.

Pubmed Data : Cardiovasc Drugs Ther. 2015 Apr ;29(2):101-3. PMID: 25869394

Article Published Date : Mar 31, 2015

Authors : Elena N Dedkova

Study Type : Commentary

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cardiovascular Disease: Prevention : CK(3250) : AC(433), Cardiovascular Diseases : CK(7342) : AC(916), Chronic Kidney Disease (CKD) : CK(147) : AC(23), Mitochondrial Dysfunction : CK(227) : AC(92)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Cardioprotective : CK(1596) : AC(409), Interleukin-6 Downregulation : CK(1137) : AC(354), Nrf2 activation : CK(177) : AC(86), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin has significant anti-inflammatory, anti-oxidant and various other features which make it a strong candidate to be included in therapeutic armamentarium for treating CKD.

Pubmed Data : Molecules. 2014 ;19(12):20139-56. Epub 2014 Dec 2. PMID: 25474287

Article Published Date : Dec 31, 2013

Authors : Siddhartha S Ghosh, Todd W B Gehr, Shobha Ghosh

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chronic Kidney Disease (CKD) : CK(147) : AC(23), Inflammation : CK(3240) : AC(882), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Renoprotective : CK(572) : AC(254)

Curcumin in combination with EPA and DHA work synergistically to reduce inflammation.

Pubmed Data : Biochem Pharmacol. 2010 Feb 1;79(3):421-30. Epub 2009 Sep 8. PMID: 19744468

Article Published Date : Feb 01, 2010

Authors : Constance Lay Lay Saw, Ying Huang, Ah-Ng Kong

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), DHA (Docosahexaenoic Acid) : CK(925) : AC(155), EPA (Eicosapentaenoic Acid) : CK(877) : AC(119)

Diseases : Cancers: All : CK(14773) : AC(4596), Inflammation : CK(3240) : AC(882)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antineoplastic Agents : CK(1158) : AC(639), Antioxidants : CK(8430) : AC(3132)

Additional Keywords : Natural Substance Synergy : CK(540) : AC(249)

Curcumin inhibits neuronal apoptosis and alleviates oxidative stress and inflammation in neurons subjected to Oxyhemoglobin.

Pubmed Data : Brain Res Bull. 2015 Nov 10 ;120:34-40. Epub 2015 Nov 10. PMID: 26551062

Article Published Date : Nov 09, 2015

Authors : Xia Li, Lei Zhao, Liang Yue, Haixiao Liu, Xiangmin Yang, Xinchuan Wang, Yan Lin, Yan Qu

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Subarachnoid hemorrhage : CK(70) : AC(15)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin is a potent therapeutic drug candidate for inflammatory and degenerative retinal and eye diseases.

Pubmed Data : Mol Nutr Food Res. 2013 Sep ;57(9):1557-68. Epub 2013 Feb 18. PMID: 23417969

Article Published Date : Aug 31, 2013

Authors : Lei-Lei Wang, Yue Sun, Kun Huang, Ling Zheng

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Diabetic Retinopathy : CK(60) : AC(23), Glaucoma : CK(164) : AC(26), Inflammation : CK(3240) : AC(882), Macular Degeneration : CK(207) : AC(34), Retinal Diseases : CK(70) : AC(23)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132)

Curcumin is a promising agent for neuropsychiatric disorders.

Pubmed Data : J Psychopharmacol. 2017 Mar ;31(3):287-302. Epub 2017 Jan 30. PMID: 28135888

Article Published Date : Feb 28, 2017

Authors : Adrian L Lopresti

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Autism : CK(617) : AC(73), Bipolar Disorder : CK(253) : AC(30), Obsessive-Compulsive Disorder : CK(188) : AC(26), Post-Traumatic Stress Disorders (PTSD) : CK(243) : AC(35)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Neuroprotective Agents : CK(2360) : AC(1099), Antioxidants : CK(1) : AC(1), Autism : CK(10) : AC(1), Autism : CK(10) : AC(1), CURCUMIN : CK(2) : AC(1), CURCUMIN : CK(2) : AC(1), CURCUMIN : CK(2) : AC(1), CURCUMIN : CK(2) : AC(1), CURCUMIN : CK(2) : AC(1)

Curcumin is a promising ingredient of novel functional foods, with protective efficacy in preventing certain diseases.

Pubmed Data : Nutrients. 2018 Oct 19 ;10(10). Epub 2018 Oct 19. PMID: 30347782

Article Published Date : Oct 18, 2018

Authors : Xiao-Yu Xu, Xiao Meng, Sha Li, Ren-You Gan, Ya Li, Hua-Bin Li

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Animal Cancers : CK(3) : AC(2), Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Inflammation : CK(3240) : AC(882), Nonalcoholic fatty liver disease (NAFLD) : CK(789) : AC(183)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Hypoglycemic Agents : CK(1446) : AC(342), Immunomodulatory : CK(1287) : AC(358), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin may be a novel treatment for neuroinflammation-mediated neurodegenerative disorders.

Pubmed Data : Int J Mol Med. 2018 Jan ;41(1):521-530. Epub 2017 Oct 27. PMID: 29115589

Article Published Date : Dec 31, 2017

Authors : Meiling Jin, Sun Young Park, Qian Shen, Yihong Lai, Xingmei Ou, Zhuo Mao, Dongxu Lin, Yangyang Yu, Weizhen Zhang

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Inflammation : CK(274) : AC(145)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Heme oxygenase-1 inducer : CK(8) : AC(5), Nrf2 activation : CK(177) : AC(86)

Curcumin may have therapeutic potential for bladder cancer patients via anti-inflammatory, antioxidant and anti-carcinogenic activities.

Pubmed Data : Oncol Rep. 2006 May;15(5):1225-31. PMID: 16596191

Article Published Date : May 01, 2006

Authors : Cheol Park, Gi Young Kim, Gun Do Kim, Byung Tae Choi, Yeong-Min Park, Yung Hyun Choi

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Turmeric : CK(5583) : AC(2569)

Diseases : Bladder Cancer : CK(349) : AC(100)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Anticarcinogenic Agents : CK(1099) : AC(519), Antioxidants : CK(8430) : AC(3132)

Curcumin oil has a protective effect against cisplatin-induced nephrotoxicity.

Pubmed Data : J Agric Food Chem. 2007 Dec 12;55(25):10150-5. Epub 2007 Nov 15. PMID: 18001039

Article Published Date : Dec 12, 2007

Authors : Anurag Kuhad, Sangeeta Pilkhwal, Sameer Sharma, Naveen Tirkey, Kanwaljit Chopra

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(319) : AC(133), Inflammation : CK(3240) : AC(882), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Renoprotective : CK(572) : AC(254), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin possesses anti-diabetic effects and mitigates diabetes complications

Pubmed Data : Curr Top Med Chem. 2015 Jun 19. Epub 2015 Jun 19. PMID: 26088351

Article Published Date : Jun 18, 2015

Authors : Seyed Fazel Nabavi, Raman Thiagarajan, Luca Rastrelli, Maria Daglia, Eduardo Sobarzo-Sanchez, Heshmatollah Alinezhad, Seyed Mohammad Nabavi

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Diabetic Complications : CK(1563) : AC(333)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132)

Additional Keywords : Advanced Glycation End Products : CK(11) : AC(2)

Curcumin prevents human aortic smooth muscle cells migration associated with the development atherosclerosis.

Pubmed Data : Nutr Metab Cardiovasc Dis. 2010 Feb;20(2):125-32. Epub 2009 May 17. PMID: 19447587

Article Published Date : Feb 01, 2010

Authors : Y-M Yu, H-C Lin

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Atherosclerosis : CK(601) : AC(150)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(287) : AC(147), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin protected the liver from chronic-ethanol induced injury through attenuating oxidative stress

Pubmed Data : Pharmacogn Mag. 2015 Oct-Dec;11(44):707-715. PMID: 26600714

Article Published Date : Sep 30, 2015

Authors : Zhang E Xiong, Wei Guo Dong, Bao Ying Wang, Qiao Yun Tong, Zhong Yan Li

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alcoholic Liver Disease : CK(152) : AC(61)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099), Nrf2 activation : CK(177) : AC(86)

Curcumin protects astrocytes from induced oxidative stress, and reverses mitochondrial damage and dysfunction induced by oxidative stress.

Pubmed Data : Neuroscience. 2016 Jul 13. Epub 2016 Jul 13. PMID: 27423629

Article Published Date : Jul 12, 2016

Authors : Amita Daverey, Sandeep K Agrawal

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Mitochondrial Dysfunction : CK(227) : AC(92), Neurodegenerative Diseases : CK(3582) : AC(932), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Cytoprotective : CK(190) : AC(94), Neuroprotective Agents : CK(2360) : AC(1099), Regenerative : CK(52) : AC(28)

Curcumin protects glial cells and promotes a microglial anti-inflammatory phenotype by a mechanism that implicates HO-1 induction.

Pubmed Data : Mol Nutr Food Res. 2015 Sep ;59(9):1690-700. Epub 2015 Jun 30. PMID: 26047311

Article Published Date : Aug 31, 2015

Authors : Esther Parada, Izaskun Buendia, Elisa Navarro, Carlos Avendaño, Javier Egea, Manuela G López

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain: Oxidative Stress : CK(79) : AC(46), Brain Inflammation : CK(274) : AC(145)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin protects intestinal mucosal barrier function of rat enteritis.

Pubmed Data : PLoS One. 2010;5(9):e12969. Epub 2010 Sep 24. PMID: 20885979

Article Published Date : Jan 01, 2010

Authors : Wei-Bing Song, Yuan-Yuan Wang, Fan-Su Meng, Qing-Hua Zhang, Jian-Ying Zeng, Li-Ping Xiao, Xin-Pei Yu, Dan-dan Peng, Lei Su, Bing Xiao, Zhen-Shu Zhang

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Intestinal Permeability : CK(245) : AC(60)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Gastroprotective : CK(155) : AC(73)

Curcumin protects the rat liver from chemically-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation.

Pubmed Data : Mol Pharmacol. 2008 Feb;73(2):399-409. Epub 2007 Nov 15. PMID: 18006644

Article Published Date : Feb 01, 2008

Authors : Yumei Fu, Shizhong Zheng, Jianguo Lin, Jan Ryerse, Anping Chen

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chemically-Induced Liver Damage : CK(634) : AC(255), Inflammation : CK(3240) : AC(882), Liver Fibrosis : CK(246) : AC(104), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099)

Curcumin reduced or eliminated colonic tumor burden with limited effects on mucosal immune responses.

Pubmed Data : Inflamm Bowel Dis. 2015 Jul 25. Epub 2015 Jul 25. PMID: 26218141

Article Published Date : Jul 24, 2015

Authors : Rita-Marie T McFadden, Claire B Larmonier, Kareem W Shehab, Monica Midura-Kiela, Rajalakshmy Ramalingam, Christy A Harrison, David G Besselsen, John H Chase, J Gregory Caporaso, Christian Jobin, Fayez K Ghishan, Pawel R Kiela

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Colitis : CK(255) : AC(111), Colon Cancer: Prevention : CK(178) : AC(57)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Anticarcinogenic Agents : CK(1099) : AC(519), Antioxidants : CK(8430) : AC(3132), Chemopreventive : CK(2835) : AC(787)

Additional Keywords : Microbiota : CK(396) : AC(101)

Curcumin reduces nitric oxide formation and associated inflammation in the rat mammary gland.

Pubmed Data : J Exp Biol. 2009 Jan;212(Pt 2):163-8. PMID: 11020339

Article Published Date : Jan 01, 2009

Authors : M Onoda, H Inano

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Breast Cancer : CK(3592) : AC(1064), Lipopolysaccharide-Induced Toxicity : CK(380) : AC(218)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antineoplastic Agents : CK(1158) : AC(639), Antioxidants : CK(8430) : AC(3132), Nitric Oxide Inhibitor : CK(223) : AC(108)

Curcumin reduces production of ROS and inflammatory mediators in HIV-1-gp120-stimulated microglia, and protects cortical neurons against HIV-1-mediated apoptosis.

Pubmed Data : PLoS One. 2013 ;8(8):e70565. Epub 2013 Aug 6. PMID: 23936448

Article Published Date : Dec 31, 2012

Authors : Luyan Guo, Yanyan Xing, Rui Pan, Mingliang Jiang, Zheng Gong, Liqing Lin, Junbing Wang, Guoyin Xiong, Jun Dong

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : HIV Infections : CK(680) : AC(219), Inflammation : CK(3240) : AC(882), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin significantly ameliorates disease symptoms in a Drosophila model of Huntington's disease.

Pubmed Data : Sci Rep. 2016 ;6:18736. Epub 2016 Jan 5. PMID: 26728250

Article Published Date : Dec 31, 2015

Authors : Anjalika Chongtham, Namita Agrawal

Study Type : Insect Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Huntington Disease : CK(91) : AC(36)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132)

Curcumin significantly inhibited the formation of advanced glycation end products (AGEs).

Pubmed Data : Mol Med Rep. 2015 Dec 28. Epub 2015 Dec 28. PMID: 26718010

Article Published Date : Dec 27, 2015

Authors : Yan Ping Sun, Jun Fei Gu, Xiao Bin Tan, Chun Fei Wang, Xiao Bin Jia, Liang Feng, Ji Ping Liu

Study Type : Human In Vitro

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Advanced Glycation End products (AGE) : CK(231) : AC(73), Endothelial Dysfunction : CK(1210) : AC(237), Inflammation : CK(3240) : AC(882), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Glycation Agents : CK(46) : AC(19), Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132)

Curcumin treatment attenuates lipopolysaccharide induced liver injury.

Pubmed Data : Biomed Pharmacother. 2016 Jul 6 ;83:302-313. Epub 2016 Jul 6. PMID: 27393927

Article Published Date : Jul 05, 2016

Authors : Wenhui Zhong, Kejian Qian, Jibin Xiong, Ke Ma, Aizhong Wang, Yan Zou

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Lipopolysaccharide-Induced Toxicity : CK(380) : AC(218), Sepsis : CK(216) : AC(61)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099)

Curcumin treatment significantly improved the neurological status evaluated during 2 weeks after brain injury.

Pubmed Data : Pharmacol Biochem Behav. 2013 Sep ;110:238-44. Epub 2013 Aug 7. PMID: 23932920

Article Published Date : Aug 31, 2013

Authors : Fariborz Samini, Saeed Samarghandian, Abasalt Borji, Gholamreza Mohammadi, Mahdi bakaian

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Inflammation : CK(274) : AC(145), Brain Injury: Traumatic : CK(99) : AC(30), Lipid Peroxidation : CK(695) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Malondialdehyde Down-regulation : CK(554) : AC(152), Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Significant Treatment Outcome : CK(3038) : AC(366)

Curcumin was found to have anti-hyperalgesic activity by decreasing oxidative stress and down regulation of inflammatory cytokines.

Pubmed Data : Neurochem Res. 2015 Mar ;40(3):463-72. Epub 2014 Dec 6. PMID: 25479948

Article Published Date : Feb 28, 2015

Authors : Ajeet Kumar Singh, Manjula Vinayak

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Hyperalgesia : CK(63) : AC(24), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Interleukin-1 beta downregulation : CK(478) : AC(205), Interleukin-6 Downregulation : CK(1137) : AC(354), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin, silybin phytosome® and α-R-lipoic acid may confer therapeutic efficacy against chronic hepatitis.

Pubmed Data : Basic Clin Pharmacol Toxicol. 2015 Oct 12. Epub 2015 Oct 12. PMID: 26457982

Article Published Date : Oct 11, 2015

Authors : Shimaa O Ali, Hebatallah A Darwish, Nabila A Ismail

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid : CK(476) : AC(116), Curcumin : CK(4417) : AC(2300)

Diseases : Chronic Hepatitis : CK(12) : AC(2)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132)

Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Curcumin-galactomannoside complex offered significant hepatoprotective effects to attenuate alcohol induced alterations to hepatic function markers.

Pubmed Data : Biomed Res Int. 2018 ;2018:9159281. Epub 2018 Sep 23. PMID: 30345312

Article Published Date : Dec 31, 2017

Authors : Naveen T Krishnareddy, Jestin V Thomas, Saritha S Nair, Johannah N Mulakal, Balu P Maliakel, I M Krishnakumar

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alcohol Toxicity : CK(337) : AC(125), Alcoholic Liver Disease : CK(152) : AC(61)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099)

Curcuminoids: Implication for inflammation and oxidative stress in cardiovascular diseases.

Pubmed Data : Phytother Res. 2019 Mar 4. Epub 2019 Mar 4. PMID: 30834628

Article Published Date : Mar 03, 2019

Authors : Cheng Li, Xiao Miao, Fengsheng Li, Binay Kumar Adhikari, Yucheng Liu, Jian Sun, Rong Zhang, Lu Cai, Quan Liu, Yonggang Wang

Study Type : Review

Additional Links

Substances : Bisdemethoxycurcumin : CK(35) : AC(19), Curcumin : CK(4417) : AC(2300), Demethoxycurcumin : CK(36) : AC(21)

Diseases : Cardiovascular Diseases : CK(7342) : AC(916)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Cardioprotective : CK(1596) : AC(409)

Liposomal curcumin may be useful for the prevention of copper sulphate induced liver injury.

Pubmed Data : Dose Response. 2018 Jul-Sep;16(3):1559325818790869. Epub 2018 Aug 9. PMID: 30116168

Article Published Date : Jun 30, 2018

Authors : Ahlam Alhusaini, Laila Fadda, Iman Hassan, Hanaa M Ali, Njood Alsaadan, Nouf Aldowsari, Azizah Aldosari, Bshayer Alharbi

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chemically-Induced Liver Damage : CK(634) : AC(255), Copper Toxicity : CK(29) : AC(13)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099)

Additional Keywords : Natural Substances Versus Drugs : CK(1698) : AC(302)

Medical therapy of asthenoteratospermia with curcumin nanomicelle supplement could improve quality of semen parameters.

Pubmed Data : Phytother Res. 2018 Mar ;32(3):514-521. Epub 2017 Nov 28. PMID: 29193350

Article Published Date : Feb 28, 2018

Authors : Fatemeh Alizadeh, Maryam Javadi, Ali Akbar Karami, Fereshteh Gholaminejad, Maria Kavianpour, Hossein Khadem Haghighian

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Infertility: Male : CK(387) : AC(95)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Malondialdehyde Down-regulation : CK(554) : AC(152), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Molecular mechanisms underlying curcumin-mediated therapeutic effects in type 2 diabetes and cancer.

Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:9698258. Epub 2018 Mar 20. PMID: 29743988

Article Published Date : Dec 31, 2017

Authors : Marzena Wojcik, Michal Krawczyk, Pawel Wojcik, Katarzyna Cypryk, Lucyna Alicja Wozniak

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cancers: All : CK(14773) : AC(4596), Diabetes Mellitus: Type 2 : CK(3572) : AC(624)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Antiproliferative : CK(2546) : AC(1685), Chemopreventive : CK(2835) : AC(787), Hypoglycemic Agents : CK(1446) : AC(342)

Natural products for promoting joint health and managing osteoarthritis.

Pubmed Data : Curr Rheumatol Rep. 2018 Sep 19 ;20(11):72. Epub 2018 Sep 19. PMID: 30232562

Article Published Date : Sep 18, 2018

Authors : Yves Henrotin, Ali Mobasheri

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Frankincense : CK(224) : AC(41), Pycnogenol (Pine Bark) : CK(666) : AC(126)

Diseases : Osteoarthritis : CK(770) : AC(115)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132)

NPs-Cur enhance the action of curcumin on several pathways implicated in the pathophysiology of Alzheimer's disease.

Pubmed Data : Mol Pharm. 2015 Dec 23. Epub 2015 Dec 23. PMID: 26618861

Article Published Date : Dec 22, 2015

Authors : Ghislain Djiokeng Paka, Sihem Doggui, Ahlem Zaghmi, Ramia Safar, Lé Dao, Andreas Reisch, Andrey Klymchenko, V Gaëlle Roullin, Olivier Joubert, Charles Ramassamy

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Phytochemicals have the potential of modulating various molecular processes, including signaling pathways involved in the development and progression of tumors.

Pubmed Data : Onco Targets Ther. 2015 ;8:2053-66. Epub 2015 Aug 6. PMID: 26273208

Article Published Date : Dec 31, 2014

Authors : Roxana Cojocneanu Petric, Cornelia Braicu, Lajos Raduly, Oana Zanoaga, Nicolae Dragos, Paloma Monroig, Dan Dumitrascu, Ioana Berindan-Neagoe

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), EGCG (Epigallocatechin gallate) : CK(721) : AC(380), Genistein : CK(578) : AC(252)

Diseases : Breast Cancer : CK(3592) : AC(1064)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Anticarcinogenic Agents : CK(1099) : AC(519), Antioxidants : CK(8430) : AC(3132), Apoptotic : CK(2958) : AC(2075), Chemotherapeutic : CK(397) : AC(152), MicroRNA modulator : CK(264) : AC(145)

Polymerized nano-curcumin has significant effects on the EAE scores and myelin repair mechanisms in an animal model of multiple sclerosis.

Pubmed Data : Neuropharmacology. 2015 Dec ;99:156-67. Epub 2015 Jul 23. PMID: 26211978

Article Published Date : Nov 30, 2015

Authors : Maryam Mohajeri, Majid Sadeghizadeh, Farhood Najafi, Mohammad Javan

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Demyelinating Diseases : CK(1671) : AC(332), Multiple Sclerosis : CK(964) : AC(184)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099), Remyelination : CK(2) : AC(1)

Additional Keywords : Gene Expression Regulation : CK(431) : AC(214)

Polyphenolic compounds could be beneficial in psychiatric disorders.

Pubmed Data : Oxid Med Cell Longev. 2015;2015:248529. Epub 2015 Jun 9. PMID: 26180581

Article Published Date : Dec 31, 2014

Authors : Jana Trebatická, Zdeňka Ďuračková

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Ginkgo biloba : CK(866) : AC(188), Green Tea : CK(2251) : AC(658), Oak : CK(44) : AC(23), Polyphenols : CK(1109) : AC(390)

Diseases : Attention Deficit Disorder : CK(136) : AC(14), Depression : CK(2043) : AC(290), Oxidative Stress : CK(3871) : AC(1382), Psychiatric Disorders : CK(123) : AC(31), Schizophrenia : CK(445) : AC(70)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132)

Protective effect of curcumin against cytomegalovirus infection in Balb/c mice.

Pubmed Data : Environ Toxicol Pharmacol. 2014 May ;37(3):1140-7. Epub 2014 Apr 21. PMID: 24802527

Article Published Date : Apr 30, 2014

Authors : Yali Lv, Ning Lei, Dan Wang, Zhuoling An, Guangrun Li, Feifei Han, He Liu, Lihong Liu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cytomegalovirus Infections : CK(99) : AC(37)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Antiviral Agents : CK(938) : AC(433), Interleukin-6 Downregulation : CK(1137) : AC(354), Malondialdehyde Down-regulation : CK(554) : AC(152), Superoxide Dismutase Up-regulation : CK(530) : AC(174), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Short term curcumin intervention ablates diabetic kidney disease progress with activating Nrf2 anti-oxidative system and anti-inflammatory efficacies in patients with T2DM.

Pubmed Data : Exp Clin Endocrinol Diabetes. 2015 Jun ;123(6):360-7. Epub 2015 Apr 14. PMID: 25875220

Article Published Date : May 31, 2015

Authors : H Yang, W Xu, Z Zhou, J Liu, X Li, L Chen, J Weng, Z Yu

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Diabetic Nephropathy : CK(140) : AC(54)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Malondialdehyde Down-regulation : CK(554) : AC(152), Nrf2 activation : CK(177) : AC(86)

Additional Keywords : Significant Treatment Outcome : CK(3038) : AC(366)

Short-term adjunctive therapy with curcuminoids can suppress systemic inflammation in patients suffering from SM-induced chronic pulmonary complications.

Pubmed Data : Drug Res (Stuttg). 2014 Sep 30. Epub 2014 Sep 30. PMID: 25268878

Article Published Date : Sep 29, 2014

Authors : Y Panahi, M Ghanei, S Bashiri, A Hajihashemi, A Sahebkar

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chemical Weapon Agent Injury : CK(26) : AC(6), Chemical Weapon Agent Injury: Sulfur Mustard : CK(31) : AC(4)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132)

Short-term supplementation with curcumin improves liver fat and transaminase levels in patients with NAFLD.

Pubmed Data : Drug Res (Stuttg). 2017 Apr ;67(4):244-251. Epub 2017 Feb 3. PMID: 28158893

Article Published Date : Mar 31, 2017

Authors : Yunes Panahi, Parisa Kianpour, Reza Mohtashami, Ramezan Jafari, Luis E Simental-Mendía, Amirhossein Sahebkar

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Polyphenols : CK(1109) : AC(390)

Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(789) : AC(183)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132)

The combination of curcumin and berberine exhibited better ameliorative effects in treating NAFLD than lovastatin.

Pubmed Data : Biomed Pharmacother. 2018 Jan 17 ;99:325-333. Epub 2018 Jan 17. PMID: 29353208

Article Published Date : Jan 16, 2018

Authors : Wu-Wen Feng, Shuang-Yu Kuang, Can Tu, Zhi-Jie Ma, Jing-Yao Pang, Yan-Hui Wang, Qing-Ce Zang, Ta-Si Liu, Yan-Ling Zhao, Xiao-He Xiao, Jia-Bo Wang

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(357) : AC(187), Curcumin : CK(4417) : AC(2300)

Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(789) : AC(183)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099)

Additional Keywords : Superiority of Natural Substances versus Drugs : CK(1316) : AC(251)

The current review provides an updated overview of the metabolism and mechanism of action of curcumin in various organ pathophysiologies.

Pubmed Data : Food Chem Toxicol. 2015 Jun 9 ;83:111-124. Epub 2015 Jun 9. PMID: 26066364

Article Published Date : Jun 08, 2015

Authors : Shatadal Ghosh, Sharmistha Banerjee, Parames C Sil

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Inflammation : CK(3240) : AC(882), Neurodegenerative Diseases : CK(3582) : AC(932), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132)

The current study summarizes the reported knowledge on therapeutic potential of curcumin against multiple sclerosis.

Pubmed Data : Neurol Sci. 2017 Oct 27. Epub 2017 Oct 27. PMID: 29079885

Article Published Date : Oct 26, 2017

Authors : Munibah Qureshi, Ebtesam A Al-Suhaimi, Fazli Wahid, Omer Shehzad, Adeeb Shehzad

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Multiple Sclerosis : CK(964) : AC(184)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132)

The information presented in this paper identifies curcumin as a promising renoprotective molecule against renal injury.

Pubmed Data : Redox Biol. 2013 ;1:448-56. Epub 2013 Sep 17. PMID: 24191240

Article Published Date : Dec 31, 2012

Authors : Joyce Trujillo, Yolanda Irasema Chirino, Eduardo Molina-Jijón, Ana Cristina Andérica-Romero, Edilia Tapia, José Pedraza-Chaverrí

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Liver Damage : CK(877) : AC(329), Liver Damage: Drug-Induced : CK(95) : AC(27), Liver Disease : CK(145) : AC(41), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Chemoprotective Agents : CK(356) : AC(146), Renoprotective : CK(572) : AC(254)

The preventive and therapeutic potential of polyphenolic nutraceuticals in Alzheimer's disease.

Pubmed Data : Adv Protein Chem Struct Biol. 2017 ;108:33-57. Epub 2017 Mar 22. PMID: 28427563

Article Published Date : Dec 31, 2016

Authors : Yousef Sawikr, Nagendra Sastry Yarla, Ilaria Peluso, Mohammad Amjad Kamal, Gjumrakch Aliev, Anupam Bishayee

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Flavonoids : CK(1215) : AC(379), Piperine : CK(169) : AC(84), Polyphenols : CK(1109) : AC(390), Resveratrol : CK(1511) : AC(865)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Brain Inflammation : CK(274) : AC(145)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), NF-kappaB Inhibitor : CK(1114) : AC(694)

These findings indicated that intranasal curcumin treatment effectively helped promote diabetic corneal epithelial/nerve wound healing.

Pubmed Data : Sci Rep. 2016 ;6:29753. Epub 2016 Jul 11. PMID: 27405815

Article Published Date : Dec 31, 2015

Authors : Chuanlong Guo, Mengshuang Li, Xia Qi, Guiming Lin, Fenghua Cui, Fengjie Li, Xianggen Wu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Diabetic Complications : CK(1563) : AC(333), Wound Healing: Delayed : CK(77) : AC(31)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132)

These results suggest a preventive therapeutic potential for C. longa and its constituent, curcumin in asthma.

Pubmed Data : Iran J Basic Med Sci. 2017 Feb ;20(2):155-165. PMID: 28293392

Article Published Date : Jan 31, 2017

Authors : Farzaneh Shakeri, Mohammad Soukhtanloo, Mohammad Hossein Boskabady

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Turmeric : CK(5583) : AC(2569)

Diseases : Asthma : CK(1157) : AC(190)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132)

These results suggest that curcumin may have great therapeutic potential in the treatment of diabetic retinopathy.

Pubmed Data : Ophthalmic Res. 2018 Mar 29. Epub 2018 Mar 29. PMID: 29597206

Article Published Date : Mar 28, 2018

Authors : Fang Yang, Jinqiang Yu, Feng Ke, Mei Lan, Dekun Li, Ke Tan, Jiaojiao Ling, Ying Wang, Kaili Wu, Dai Li

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Diabetic Retinopathy : CK(60) : AC(23)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Hypoglycemic Agents : CK(1446) : AC(342), Vascular Endothelial Growth Factor Inhibitors : CK(123) : AC(61)

This review focuses on the different targets of curcumin to treat cancer.

Pubmed Data : Asian Pac J Cancer Prev. 2016 ;17(6):2735-9. PMID: 27356682

Article Published Date : Dec 31, 2015

Authors : Muhammad Imran Qadir, Syeda Tahira Qousain Naqvi, Syed Aun Muhammad

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cancers: All : CK(14773) : AC(4596)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Anticarcinogenic Agents : CK(1099) : AC(519), Antioxidants : CK(8430) : AC(3132), Chemopreventive : CK(2835) : AC(787)

This review summarizes the understanding of chemopreventive effects of curcumin in the prevention of cancer via the regulation of various cell signaling and genetic pathways.

Pubmed Data : Biomed Res Int. 2014 ;2014:761608. Epub 2014 Sep 10. PMID: 25295272

Article Published Date : Dec 31, 2013

Authors : Arshad H Rahmani, Mohammad A Al Zohairy, Salah M Aly, Masood A Khan

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Curcumin: Degradiation byproducts : CK(13) : AC(8)

Diseases : Cancers: All : CK(14773) : AC(4596)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Apoptotic : CK(2958) : AC(2075), Chemopreventive : CK(2835) : AC(787), NF-kappaB Inhibitor : CK(1114) : AC(694)

This reviews the effects of curcumin on endometriosis and possible molecular mechanisms are discussed.

Pubmed Data : Biomed Pharmacother. 2017 Oct 25 ;97:91-97. Epub 2017 Oct 25. PMID: 29080464

Article Published Date : Oct 24, 2017

Authors : Tahereh Arablou, Roya Kolahdouz-Mohammadi

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Turmeric : CK(5583) : AC(2569)

Diseases : Endometriosis : CK(164) : AC(35)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Anti-metastatic : CK(634) : AC(414), Antioxidants : CK(8430) : AC(3132)

This reviews the favorable results from the use of herbal and plant products in inflammatory bowel disease.

Pubmed Data : Ann Gastroenterol. 2016 Jul-Sep;29(3):268-81. Epub 2016 Feb 20. PMID: 27366027

Article Published Date : Jun 30, 2016

Authors : John K Triantafillidis, Aikaterini Triantafyllidi, Constantinos Vagianos, Apostolos Papalois

Study Type : Review

Additional Links

Substances : Aloe Vera : CK(434) : AC(102), Artemisinin : CK(30) : AC(25), Curcumin : CK(4417) : AC(2300), Frankincense : CK(224) : AC(41), Green Tea : CK(2251) : AC(658), Lemongrass : CK(23) : AC(9), Panax Notoginseng : CK(51) : AC(18), Wormwood : CK(60) : AC(20)

Diseases : Crohn's Disease : CK(156) : AC(32), Inflammatory Bowel Diseases : CK(1052) : AC(197), Ulcerative Colitis : CK(347) : AC(69)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132)

Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

This reviews the neuroprotective roles of these herbs and summarizes their anti-inflammatory, antioxidant, and anti-apoptotic effects in PD.

Pubmed Data : Am J Transl Res. 2015 ;7(7):1189-202. Epub 2015 Jul 15. PMID: 26328004

Article Published Date : Dec 31, 2014

Authors : Wenyu Fu, Wenxin Zhuang, Shuanhu Zhou, Xin Wang

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Ginsenosides : CK(197) : AC(84), Resveratrol : CK(1511) : AC(865)

Diseases : Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

This study demonstrates a novel role for natural occurring polyphenols as PDE inhibitors that enhance pancreatic β-cell function.

Pubmed Data : J Endocrinol. 2014 Nov ;223(2):107-17. PMID: 25297556

Article Published Date : Oct 31, 2014

Authors : Michael Rouse, Antoine Younès, Josephine M Egan

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Resveratrol : CK(1511) : AC(865)

Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Pancreato Protective Agents : CK(40) : AC(23), Phosphodiesterase Inhibitors : CK(1) : AC(1)

Additional Keywords : Dose Response : CK(1519) : AC(574), Gene Expression Regulation : CK(431) : AC(214)

Using curcumin effectively prevented intestinal ischemia reperfusion injury induced lung injury.

Pubmed Data : Int J Clin Exp Pathol. 2015 ;8(4):3451-9. Epub 2015 Apr 1. PMID: 26097529

Article Published Date : Dec 31, 2014

Authors : Zhe Fan, Jihong Yao, Yang Li, Xiaowei Hu, Huizhu Shao, Xiaofeng Tian

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Intestinal Ischemia : CK(12) : AC(6)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), NF-kappaB Inhibitor : CK(1114) : AC(694)

A combined dosage of tetrahydrocurcumin and chlorogenic acid protects against experimentally induced type 2 diabetes in rats.

Pubmed Data : Mol Cell Biochem. 2010 Aug;341(1-2):109-17. Epub 2010 Mar 26. PMID: 20339905

Article Published Date : Aug 01, 2010

Authors : Leelavinothan Pari, Krishnamoorthy Karthikesan, Venugopal P Menon

Study Type : Animal Study

Additional Links

Substances : Chlorogenic Acid : CK(13) : AC(7), Curcumin : CK(4417) : AC(2300), Tetrahydrocurcumin : CK(80) : AC(39)

Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

A mixture of curcumin, hesperidin and rutin ameliorates hepatic oxidative stress caused by STZ-induced hyperglycemia.

Pubmed Data : Curr Neurovasc Res. 2015 Aug 12. Epub 2015 Aug 12. PMID: 26265154

Article Published Date : Aug 11, 2015

Authors : Mayur S Parmar, Ismail Syed, Joshua P Gray, Sidhartha D Ray

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Hesperidin : CK(239) : AC(75), Rutin : CK(180) : AC(75)

Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Hyperglycemia : CK(539) : AC(130), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099), Hypoglycemic Agents : CK(1446) : AC(342), Hypolipidemic : CK(1288) : AC(265), Superoxide Dismutase Up-regulation : CK(530) : AC(174)

Antioxidant therapies for traumatic brain injury.

Pubmed Data : Neurotherapeutics. 2010 Jan;7(1):51-61. PMID: 20129497

Article Published Date : Jan 01, 2010

Authors : Edward D Hall, Radhika A Vaishnav, Ayman G Mustafa

Study Type : Review

Additional Links

Substances : Alpha-Lipoic Acid : CK(476) : AC(116), Antioxidant formulas : CK(492) : AC(76), Curcumin : CK(4417) : AC(2300), Resveratrol : CK(1511) : AC(865)

Diseases : Brain Injury: Traumatic : CK(99) : AC(30), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Antiviral therapies based on antioxidants are promising therapeutic agents against japanese encephalitis.

Pubmed Data : Int J Infect Dis. 2014 Jul ;24:30-6. Epub 2014 Apr 26. PMID: 24780919

Article Published Date : Jun 30, 2014

Authors : Yu Zhang, Zehua Wang, Huan Chen, Zongtao Chen, Yanping Tian

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Encephalitis: Japanese : CK(17) : AC(8), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Infective Agents : CK(43) : AC(18), Antioxidants : CK(8430) : AC(3132), Antiviral Agents : CK(938) : AC(433)

Additional Keywords : Antioxidants : CK(1) : AC(1), Selective Cytotoxicity : CK(158) : AC(112)

Article provides evidence that both resveratrol and curcumin possess great potential both as chemopreventive agents and anticancer drugs.

Pubmed Data : Molecules. 2010 ;15(10):7035-74. Epub 2010 Oct 12. PMID: 20944521

Article Published Date : Jan 01, 2010

Authors : Mareike Kelkel, Claus Jacob, Mario Dicato, Marc Diederich

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Resveratrol : CK(1511) : AC(865), Stilbenes : CK(153) : AC(106)

Diseases : Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075), Cell cycle arrest : CK(810) : AC(612)

Anti Therapeutic Actions : Chemotherapy : CK(352) : AC(60)

Cadmium induced lipid peroxidation is abolished by curcumin treatment in the animal model.

Pubmed Data : Acta Neurol Scand Suppl. 1994;154:32-41. PMID: 15177643

Article Published Date : Jan 01, 1994

Authors : Vladislav Eybl, Dana Kotyzová, Monika Bludovská

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cadmium Poisoning : CK(131) : AC(62), Lipid Peroxidation : CK(695) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Capsaicin, dihydrocapsaicin, and curcumin inhibit copper-induced oxidation of human serum lipids.

Pubmed Data : J Agric Food Chem. 2006 Aug 23;54(17):6436-9. PMID: 16910741

Article Published Date : Aug 23, 2006

Authors : Kiran D K Ahuja, Dale A Kunde, Madeleine J Ball, Dominic P Geraghty

Study Type : In Vitro Study

Additional Links

Substances : Capsaicin : CK(141) : AC(57), Curcumin : CK(4417) : AC(2300), Dihydrocapsaicin : CK(1) : AC(1)

Diseases : Cholesterol: Oxidation : CK(518) : AC(117), Copper Toxicity : CK(29) : AC(13), Lipid Peroxidation : CK(695) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Consumption of curcumin may be a plausible way to prevent quinoxaline 1,4-dioxides-mediated oxidative stress and genotoxicity in human or animals.

Pubmed Data : Toxicol Mech Methods. 2015 May ;25(4):340-6. Epub 2015 May 21. PMID: 25996037

Article Published Date : Apr 30, 2015

Authors : Chongshan Dai, Shusheng Tang, Daowen Li, Kena Zhao, Xilong Xiao

Study Type : Human In Vitro

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : DNA damage : CK(1017) : AC(387), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Genoprotective : CK(270) : AC(97)

Adverse Pharmacological Actions : Genotoxic : CK(201) : AC(78)

Curcumin (in low doses) is protective against ethanol-induced liver damage.

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):47-60. Epub 2008 Aug 21. PMID: 18716759

Article Published Date : Jan 01, 2009

Authors : Asser I Ghoneim

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alcohol Toxicity : CK(337) : AC(125), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Apoptotic : CK(2958) : AC(2075), Hepatoprotective : CK(2523) : AC(1099)

Additional Keywords : Less is More : CK(21) : AC(3)

Curcumin activates defensive genes and protects neurons against oxidative stress.

Pubmed Data : Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):395-403. PMID: 16677086

Article Published Date : Mar 01, 2006

Authors : Giovanni Scapagnini, Claudia Colombrita, Marialaura Amadio, Velia D'Agata, Enrico Arcelli, Maria Sapienza, Alessandro Quattrone, Vittorio Calabrese

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin administration ameliorated the induced effects of aflatoxin B1.

Pubmed Data : Phytother Res. 2015 Jan ;29(1):134-40. Epub 2014 Oct 8. PMID: 25639897

Article Published Date : Dec 31, 2014

Authors : S M El-Bahr

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Lipid Peroxidation : CK(695) : AC(255), Liver Damage: Aflatoxin-Induced : CK(35) : AC(15), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099), Superoxide Dismutase Up-regulation : CK(530) : AC(174)

Curcumin administration ameliorates oxidative stress-induced apoptosis in osteoblasts.

Pubmed Data : Cell Physiol Biochem. 2017 Feb 8 ;41(2):661-677. Epub 2017 Feb 8. PMID: 28291961

Article Published Date : Feb 07, 2017

Authors : Panpan Dai, Yixin Mao, Xiaoyu Sun, Xumin Li, Ibrahim Muhammad, Weiyan Gu, Dafeng Zhang, Yu Zhou, Jianfeng Ma, Zhenyu Ni, Shengbin Huang

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Osteoporosis : CK(1302) : AC(257), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Osteoprotective : CK(20) : AC(6)

Curcumin ameliorates aflatoxin-induced lipid peroxidation in liver, kidney and testis of mice.

Pubmed Data : Acta Pol Pharm. 2007 Sep-Oct;64(5):413-6. PMID: 18540160

Article Published Date : Sep 01, 2007

Authors : Neeta Mathuria, Ramtej J Verma

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Aflatoxicosis : CK(143) : AC(45), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin ameliorates cognitive dysfunction and oxidative damage in phenobarbitone and carbamazepine administered rats.

Pubmed Data : Eur J Pharmacol. 2010 Oct 10;644(1-3):106-12. Epub 2010 Jul 24. PMID: 20667451

Article Published Date : Oct 10, 2010

Authors : K H Reeta, Jogender Mehla, Yogendra Kumar Gupta

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Drug-Induced Toxicity : CK(562) : AC(83), Memory Disorders : CK(344) : AC(104), Memory Disorders: Drug-Induced : CK(101) : AC(26), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anticonvulsants : CK(238) : AC(67), Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin ameliorates oxidative stress during nicotine-induced lung toxicity in rats.

Pubmed Data : Ital J Biochem. 2004 Jul;53(2):82-6. PMID: 15646012

Article Published Date : Jul 01, 2004

Authors : Chandran Kalpana, Venugopal Padmanabhan Menon

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Nicotine/Tobacco Toxicity : CK(118) : AC(40), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin ameliorates sodium arsenite-induced oxidative damage and lipid peroxidation in different rat organs.

Pubmed Data : Molecules. 2009;14(3):1098-110. Epub 2009 Mar 10. PMID: 19049818

Article Published Date : Jan 01, 2009

Authors : Fatma M El-Demerdash, Mokhtar I Yousef, Fatma M E Radwan

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Arsenic Poisoning : CK(160) : AC(49), Lipid Peroxidation : CK(695) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin and ascorbic acid exhibit antioxidant and anticarcinogenic properties.

Pubmed Data : Cancer Lett. 1992 Apr 30;63(3):237-41. PMID: 1576592

Article Published Date : Apr 30, 1992

Authors : S C Sahu, M C Washington

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Vitamin C : CK(2484) : AC(569)

Diseases : Cancers: All : CK(14773) : AC(4596), DNA damage : CK(1017) : AC(387), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Chemopreventive : CK(2835) : AC(787)

Curcumin and Boswellia serrate has beneficial effects on glycoxidation and lipid peroxidation in chronically exercising master athletes.

Pubmed Data : Nutrients. 2016 Nov 21 ;8(11). Epub 2016 Nov 21. PMID: 27879642

Article Published Date : Nov 20, 2016

Authors : Nino Cristiano Chilelli, Eugenio Ragazzi, Romina Valentini, Chiara Cosma, Stefania Ferraresso, Annunziata Lapolla, Giovanni Sartore

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Frankincense : CK(224) : AC(41)

Diseases : Advanced Glycation End products (AGE) : CK(231) : AC(73), Lipid Peroxidation : CK(695) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Additional Keywords : Phytotherapy : CK(1216) : AC(221), Plant Extracts : CK(7645) : AC(2539)

Curcumin and capsaicin have hypolipidemic and antioxidant effects in high-fat-fed rats.

Pubmed Data : Can J Physiol Pharmacol. 2007 Jun;85(6):588-96. PMID: 17823620

Article Published Date : Jun 01, 2007

Authors : H Manjunatha, K Srinivasan

Study Type : Animal Study

Additional Links

Substances : Capsaicin : CK(141) : AC(57), Curcumin : CK(4417) : AC(2300)

Diseases : Hyperlipidemia : CK(670) : AC(155), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hypolipidemic : CK(1288) : AC(265)

Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice.

Pubmed Data : J Nutr. 2001 Aug;131(8):2090-5. PMID: 11481399

Article Published Date : Aug 01, 2001

Authors : K Okada, C Wangpoengtrakul, T Tanaka, S Toyokuni, K Uchida, T Osawa

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Tetrahydrocurcumin : CK(80) : AC(39)

Diseases : Kidney Damage : CK(193) : AC(64), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anticarcinogenic Agents : CK(1099) : AC(519), Antioxidants : CK(8430) : AC(3132), Renoprotective : CK(572) : AC(254)

Curcumin and piperine prevents chemically-induced oral cancer.

Pubmed Data : Singapore Med J. 2009 Feb;50(2):139-46. PMID: 19296028

Article Published Date : Feb 01, 2009

Authors : S Manoharan, S Balakrishnan, V P Menon, L M Alias, A R Reena

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Piperidines : CK(59) : AC(22)

Diseases : Oral Cancer : CK(223) : AC(86), Oxidative Stress : CK(3871) : AC(1382), Squamous cell carcinoma : CK(203) : AC(75)

Pharmacological Actions : Anticarcinogenic Agents : CK(1099) : AC(519), Antioxidants : CK(8430) : AC(3132)

Curcumin and tetrahydrocurcumin can alleviate vascular dysfunction and high blood pressure caused by cadmium toxicity.

Pubmed Data : Tohoku J Exp Med. 2016 ;239(1):25-38. PMID: 27151191

Article Published Date : Dec 31, 2015

Authors : Upa Kukongviriyapan, Kwanjit Apaijit, Veerapol Kukongviriyapan

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Tetrahydrocurcumin : CK(80) : AC(39)

Diseases : Cadmium Poisoning : CK(131) : AC(62), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antihypertensive Agents : CK(1178) : AC(164), Antioxidants : CK(8430) : AC(3132)

Problem Substances : Cadmium : CK(132) : AC(26)

Curcumin and turmeric inhibit adverse consequences of lipid peroxidation.

Pubmed Data : J Ethnopharmacol. 2007 Mar 21;110(2):368-73. Epub 2006 Oct 13. PMID: 17116380

Article Published Date : Mar 21, 2007

Authors : Biji T Kurien, R Hal Scofield

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Turmeric : CK(5583) : AC(2569)

Diseases : Lipid Peroxidation : CK(695) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin and vitamin E were shown to protect rat lungs from oxidative damage.

Pubmed Data : Hum Exp Toxicol. 2014 Sep 17. Epub 2014 Sep 17. PMID: 25233897

Article Published Date : Sep 16, 2014

Authors : S Hassani, Mr Sepand, A Jafari, J Jaafari, R Rezaee, M Zeinali, F Tavakoli, K Razavi-Azarkhiavi

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Vitamin E : CK(1881) : AC(335)

Diseases : Lipid Peroxidation : CK(695) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Superoxide Dismutase Up-regulation : CK(530) : AC(174)

Curcumin attenuated glutamate neurotoxicity by inhibiting ER stress-associated TXNIP/NLRP3 inflammasome activation.

Pubmed Data : Toxicol Appl Pharmacol. 2015 Jul 1 ;286(1):53-63. Epub 2015 Mar 16. PMID: 25791922

Article Published Date : Jun 30, 2015

Authors : Ying Li, Jia Li, Shanshan Li, Yi Li, Xiangxiang Wang, Baolin Liu, Qiang Fu, Shiping Ma

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin attenuated hypertension-induced oxidative stress and vascular structural modifications.

Pubmed Data : Nitric Oxide. 2014 Nov 15 ;42:44-53. Epub 2014 Sep 4. PMID: 25194767

Article Published Date : Nov 14, 2014

Authors : Orachorn Boonla, Upa Kukongviriyapan, Poungrat Pakdeechote, Veerapol Kukongviriyapan, Patchareewan Pannangpetch, Parichat Prachaney, Stephen E Greenwald

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Endothelial Dysfunction : CK(1210) : AC(237), Hypertension : CK(2984) : AC(406), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antihypertensive Agents : CK(1178) : AC(164), Antioxidants : CK(8430) : AC(3132), Nitric Oxide Enhancer : CK(190) : AC(47), Vasodilator Agents : CK(347) : AC(74)

Curcumin attenuated neurodegeneration in this animal model Alzheimer's disease.

Pubmed Data : J Alzheimers Dis. 2016 Apr 5. Epub 2016 Apr 5. PMID: 27060945

Article Published Date : Apr 04, 2016

Authors : Han-Chang Huang, Bo-Wen Zheng, Yu Guo, Jian Zhao, Jiang-Yan Zhao, Xiao-Wei Ma, Zhao-Feng Jiang

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin attenuates alcohol toxicity.

Pubmed Data : J Pharm Pharm Sci. 2004 Aug 20;7(2):274-83. Epub 2004 Aug 20. PMID: 15367386

Article Published Date : Aug 20, 2004

Authors : Rajagopalan Rukkumani, Kode Aruna, Penumathsa Suresh Varma, Kallikat Narayanan Rajasekaran, Venugopal Padmanabhan Menon

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alcohol Toxicity : CK(337) : AC(125), Chemically-Induced Liver Damage : CK(634) : AC(255), Lipid Peroxidation : CK(695) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099)

Curcumin attenuates cadmium-induced tisse damage in mice.

Pubmed Data : J Appl Toxicol. 2006 May-Jun;26(3):207-12. PMID: 16345010

Article Published Date : May 01, 2006

Authors : Vladislav Eybl, Dana Kotyzová, Ladislav Lesetický, Monika Bludovská, Jaroslav Koutenský

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cadmium Poisoning : CK(131) : AC(62), Lipid Peroxidation : CK(695) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099)

Curcumin attenuates gentamicin-induced kidney oxidative damage in rats.

Pubmed Data : Food Chem Toxicol. 2006 Sep;44(9):1443-8. Epub 2006 May 20. PMID: 16814915

Article Published Date : Sep 01, 2006

Authors : E O Farombi, M Ekor

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chemotherapy-Induced Toxicity: Gentamicin : CK(54) : AC(28), Kidney Damage: Drug-Induced : CK(98) : AC(24), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Bacterial Agents : CK(1367) : AC(475), Antioxidants : CK(8430) : AC(3132), Renoprotective : CK(572) : AC(254)

Additional Keywords : Drug: Gentamicin : CK(4) : AC(2), Gentamicin : CK(4) : AC(2)

Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction.

Pubmed Data : Arch Toxicol. 2008 Jul;82(7):471-81. Epub 2007 Nov 30. PMID: 18060385

Article Published Date : Jul 01, 2008

Authors : Nageswaran Sivalingam, Jayasree Basivireddy, Kunissery A Balasubramanian, Molly Jacob

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Drug-Induced Toxicity: Indomethacin : CK(25) : AC(13), Mitochondrial Diseases : CK(227) : AC(92), Mitochondrial Dysfunction : CK(227) : AC(92), NSAID-induced toxicity : CK(314) : AC(95), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Additional Keywords : Drug: Indomethacin : CK(43) : AC(24)

Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats.

Pubmed Data : J Egypt Natl Canc Inst. 2008 Jun;20(2):141-8. PMID: 20029470

Article Published Date : Jun 01, 2008

Authors : Ramadan A M Hemeida, Omar M Mohafez

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Drug Toxicity: Methotrexate : CK(39) : AC(18), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin attenuates oxidative damage in animals treated with a renal carcinogen, ferric nitrilotriacetate (Fe-NTA).

Pubmed Data : Mol Cell Biochem. 2009 Apr;324(1-2):157-64. Epub 2009 Jan 23. PMID: 19165575

Article Published Date : Apr 01, 2009

Authors : Mohammad Iqbal, Yasumasa Okazaki, Shigeru Okada

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chemical Exposure : CK(67) : AC(21), Kidney Damage : CK(193) : AC(64), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Chemopreventive : CK(2835) : AC(787), Renoprotective : CK(572) : AC(254)

Curcumin attenuates the kainic acid-induced hippocampal cell death in the mice.

Pubmed Data : Carcinogenesis. 2009 Nov;30(11):1949-56. Epub 2009 Sep 30. PMID: 17300872

Article Published Date : Nov 01, 2009

Authors : Hyun Joo Shin, Ji Yeong Lee, Eunyung Son, Dong Hun Lee, Hyun Joon Kim, Sang Soo Kang, Gyeong Jae Cho, Wan Sung Choi, Gu Seob Roh

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Injury: Hippocampal Damage : CK(39) : AC(18), Neurodegenerative Diseases : CK(3582) : AC(932), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Enzyme Inhibitors : CK(473) : AC(251), Excitatory Amino Acid Agonists : CK(7) : AC(4), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin co-treatment seems to prevent oxidative damage and found to delay the development of cataract.

Pubmed Data : Indian J Exp Biol. 2004 Jun;42(6):601-3. PMID: 15260112

Article Published Date : Jun 01, 2004

Authors : S Padmaja, T N Raju

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cataract : CK(196) : AC(61), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Enzyme Inhibitors : CK(473) : AC(251)

Curcumin could attenuate cadmium quantum dots induced oxidative stress and lethality.

Pubmed Data : Environ Toxicol Pharmacol. 2016 Jan 4 ;42:55-62. Epub 2016 Jan 4. PMID: 26773363

Article Published Date : Jan 03, 2016

Authors : Swati Srivastava, Aakanksha Pant, Shalini Trivedi, Rakesh Pandey

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cadmium Poisoning : CK(131) : AC(62), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin could effectively inhibit quinocetone induced apoptosis and inflammatory response in L02 cells.

Pubmed Data : Food Chem Toxicol. 2016 Jun 29. Epub 2016 Jun 29. PMID: 27375190

Article Published Date : Jun 28, 2016

Authors : Chongshan Dai, Bin Li, Yan Zhou, Daowen Li, Shen Zhang, Hui Li, Xilong Xiao, Shusheng Tang

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Inflammation : CK(3240) : AC(882), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Antioxidants : CK(8430) : AC(3132), Cytoprotective : CK(190) : AC(94), NF-kappaB Inhibitor : CK(1114) : AC(694), Nrf2 activation : CK(177) : AC(86)

Additional Keywords : Dose Response : CK(1519) : AC(574)

Curcumin could partially protect against reoxygenation injury in animals.

Pubmed Data : Adv Pharmacol Sci. 2016;2016:6173648. Epub 2016 Jan 21. PMID: 26904113

Article Published Date : Dec 31, 2015

Authors : Ermita I Ibrahim Ilyas, Busjra M Nur, Sonny P Laksono, Anton Bahtiar, Ari Estuningtyas, Caecilia Vitasyana, Dede Kusmana, Frans D Suyatna, Muhammad Kamil Tadjudin, Hans-Joachim Freisleben

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Myocardial Ischemia : CK(137) : AC(61), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Cardioprotective : CK(1596) : AC(409)

Curcumin counteracts the aluminium-induced ageing-related alterations in the rat brain.

Pubmed Data : Biogerontology. 2009 Aug;10(4):489-502. Epub 2008 Nov 20. PMID: 19020987

Article Published Date : Aug 01, 2009

Authors : Deepak Sharma, Pallavi Sethi, Ezaj Hussain, Rameshwar Singh

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Aging : CK(1658) : AC(438), Aging: Brain : CK(248) : AC(85), Aluminum Toxicity : CK(207) : AC(75), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin eliminates the effects of AGEs on the divergent regulation of gene expression of RAGE and AGE-R1 in HSC in vitro.

Pubmed Data : Lab Invest. 2014 May ;94(5):503-16. Epub 2014 Mar 10. PMID: 24614199

Article Published Date : Apr 30, 2014

Authors : Youcai Tang, Anping Chen

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Advanced Glycation End products (AGE) : CK(231) : AC(73), Liver Cirrhosis : CK(395) : AC(56), Nonalcoholic fatty liver disease (NAFLD) : CK(789) : AC(183), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099), NF-E2-Related Factor-2 (Nrf2) Modulator : CK(48) : AC(26)

Additional Keywords : Gene Expression Regulation : CK(431) : AC(214), Plant Extracts : CK(7645) : AC(2539)

Curcumin enhanced therapeutic efficacy of M. oleifera root extract and showed better antioxidant potential against beryllium toxicity.

Pubmed Data : Pharm Biol. 2015 Oct ;53(10):1465-73. Epub 2015 Apr 8. PMID: 25853973

Article Published Date : Sep 30, 2015

Authors : Narottam Das Agrawal, Satendra Kumar Nirala, Sangeeta Shukla, Ramesh Mathur

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Moringa oleifera : CK(207) : AC(106)

Diseases : Beryllium-induced Toxicity : CK(4) : AC(2), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099), Renoprotective : CK(572) : AC(254)

Curcumin exhibits anti-pre-cancer activity by increasing levels of vitamins C and E, and preventing lipid peroxidation and DNA damage.

Pubmed Data : J Oral Sci. 2010;52(2):251-6. PMID: 20587949

Article Published Date : Jan 01, 2010

Authors : Balwant Rai, Jasdeep Kaur, Reinhilde Jacobs, Jaipaul Singh

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Vitamin C : CK(2484) : AC(569), Vitamin E : CK(1881) : AC(335)

Diseases : DNA damage : CK(1017) : AC(387), Leukoplakia : CK(72) : AC(9), Lichen Planus : CK(64) : AC(8), Oxidative Stress : CK(3871) : AC(1382), Precancerous Conditions : CK(22) : AC(3)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin has a beneficial therapeutic effect in diabetes-induced heart failure.

Pubmed Data : J Biochem Mol Toxicol. 2014 Jun ;28(6):263-70. Epub 2014 Apr 24. PMID: 24760747

Article Published Date : May 31, 2014

Authors : Osama M Abo-Salem, Gamaleldin I Harisa, Tarek M Ali, El-Sayed M El-Sayed, Fatma M Abou-Elnour

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Diabetic Complications : CK(1563) : AC(333), Heart Failure : CK(948) : AC(126), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Interleukin-6 Downregulation : CK(1137) : AC(354), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin has a cytoprotective and immunomodulating effect in rats subjected to carbon tetrachloride-induced oxidative stress.

Pubmed Data : Br J Rheumatol. 1994 Sep;33(9):847-52. PMID: 18340409

Article Published Date : Sep 01, 1994

Authors : H A Abu-Rizq, M H Mansour, A M Safer, M Afzal

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chemical Exposure : CK(67) : AC(21), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Cytoprotective : CK(190) : AC(94)

Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Curcumin has a neuroprotective effect against homocysteine-induced cognitive impairment and oxidative stress in the rat.

Pubmed Data : Pharmacol Biochem Behav. 2010 Oct;96(4):378-85. Epub 2010 Jul 6. PMID: 20619287

Article Published Date : Oct 01, 2010

Authors : Amin Ataie, Masoumeh Sabetkasaei, Abbas Haghparast, Akbar Hajizadeh Moghaddam, Behrang Kazeminejad

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cognitive Decline/Dysfunction : CK(1163) : AC(215), Homocysteine: Elevated : CK(431) : AC(63), Neurodegenerative Diseases : CK(3582) : AC(932), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin has a protective effect against oxidative damage on skin cells.

Pubmed Data : J Trauma. 2001 Nov;51(5):927-31. PMID: 11706342

Article Published Date : Nov 01, 2001

Authors : T T Phan, P See, S T Lee, S Y Chan

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Infective Agents: Urinary : CK(3) : AC(2), Antioxidants : CK(8430) : AC(3132), Enzyme Inhibitors : CK(473) : AC(251)

Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Curcumin has a protective effect on eccentric exercise induced muscle damage.

Pubmed Data : Int J Vitam Nutr Res. 2014 ;84(3-4):163-72. PMID: 26098480

Article Published Date : Dec 31, 2013

Authors : Ismail Boz, Muaz Belviranli, Nilsel Okudan

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Muscle Damage: Exercise-Induced : CK(155) : AC(22), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Malondialdehyde Down-regulation : CK(554) : AC(152)

Curcumin has anti-ulcer activity in experimental gastric ulcer in rats.

Pubmed Data : Biomed Environ Sci. 2009 Dec;22(6):488-95. PMID: 20337222

Article Published Date : Dec 01, 2009

Authors : M Tuorkey, K Karolin

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Gastric Ulcer : CK(289) : AC(117), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Ulcer Agents : CK(213) : AC(84), Antioxidants : CK(8430) : AC(3132), Gastroprotective : CK(155) : AC(73), Interleukin-6 Downregulation : CK(1137) : AC(354)

Curcumin has antioxidant activity.

Pubmed Data : Mutat Res. 1994 Dec 1;311(2):249-55. PMID: 7526190

Article Published Date : Dec 01, 1994

Authors : M Subramanian, Sreejayan, M N Rao, T P Devasagayam, B B Singh

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : DNA damage : CK(1017) : AC(387), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Oxidative Stress : CK(3871) : AC(1382), Antioxidants : CK(8430) : AC(3132)

Curcumin has neuroprotective effects against a fungal toxin.

Pubmed Data : Methods Find Exp Clin Pharmacol. 2007 Jan-Feb;29(1):19-25. PMID: 17344940

Article Published Date : Jan 01, 2007

Authors : P Kumar, S S V Padi, P S Naidu, A Kumar

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Fungal Infection : CK(282) : AC(136), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Curcumin improves outcomes and attenuates focal cerebral ischemic injury.

Pubmed Data : Neurochem Res. 2010 Mar;35(3):374-9. Epub 2009 Sep 23. PMID: 19774461

Article Published Date : Mar 01, 2010

Authors : Jing Zhao, Shanshan Yu, Weiping Zheng, Gang Feng, Guobiao Luo, Linli Wang, Yong Zhao

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cerebral Ischemia : CK(229) : AC(77), Middle Cerebral Artery Occlusion (MCAO) : CK(73) : AC(28), Oxidative Stress : CK(3871) : AC(1382), Stroke: Recovery : CK(70) : AC(11)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin inhibits glutamate-induced excitoxicity in vitro.

Pubmed Data : Mol Cell Biochem. 2007 Apr;298(1-2):187-94. Epub 2006 Nov 25. PMID: 17131042

Article Published Date : Apr 01, 2007

Authors : Hyun-Woo Suh, Seongman Kang, Ki-Sun Kwon

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Excitotoxicity : CK(58) : AC(35), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin inhibits lipid peroxidation and protein oxidation in rat liver mitochondria.

Pubmed Data : Biochim Biophys Acta. 2006 Jan;1760(1):70-7. Epub 2005 Oct 3. PMID: 16236451

Article Published Date : Jan 01, 2006

Authors : Qing-Yi Wei, Wei-Feng Chen, Bo Zhou, Li Yang, Zhong-Li Liu

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chemically-Induced Liver Damage : CK(634) : AC(255), Lipid Peroxidation : CK(695) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099)

Curcumin inhibits nicotine-induced toxicity.

Pubmed Data : J Med Food. 2004;7(4):467-71. PMID: 15671691

Article Published Date : Jan 01, 2004

Authors : C Kalpana, Venugopal P Menon

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Nicotine/Tobacco Toxicity : CK(118) : AC(40), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin inhibits reactive oxygen species formation and vascular hyperpermeability following haemorrhagic shock.

Pubmed Data : Clin Exp Pharmacol Physiol. 2010 Sep;37(9):939-44. Epub 2010 May 28. PMID: 20528978

Article Published Date : Sep 01, 2010

Authors : Binu Tharakan, Felicia A Hunter, W Roy Smythe, Ed W Childs

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Hemorrhagic Shock : CK(6) : AC(3), Oxidative Stress : CK(3871) : AC(1382), Vascular Diseases: Hyperpermeability : CK(2) : AC(1)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin may attenuate lead and cadmium-induce neurotoxicity.

Pubmed Data : Anesth Analg. 2001 Oct;93(4):912-6. PMID: 14729307

Article Published Date : Oct 01, 2001

Authors : Sheril Daniel, Janice L Limson, Amichand Dairam, Gareth M Watkins, Santy Daya

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Injury: Hippocampal Damage : CK(39) : AC(18), Cadmium Poisoning : CK(131) : AC(62), Lead Poisoning : CK(205) : AC(60), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

curcumin may be an effective strategy to combat the genotoxicity of arsenic.

Pubmed Data : Asian Pac J Cancer Prev. 2010;11(1):239-47. PMID: 20593964

Article Published Date : Jan 01, 2010

Authors : Jaydip Biswas, Soumi Roy, Sutapa Mukherjee, Dona Sinha, Madhumita Roy

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Arsenic Poisoning : CK(160) : AC(49), DNA damage : CK(1017) : AC(387), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin may be effective in the management of diet-induced oxidative stress.

Pubmed Data : Sci Pharm. 2015 ;83(1):159-75. Epub 2014 Nov 4. PMID: 26839808

Article Published Date : Dec 31, 2014

Authors : Nachimuthu Maithili Karpaga Selvi, Magadi Gopalakrishna Sridhar, Rathinam Palamalai Swaminathan, Ramalingam Sripradha

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : High Fat Diet : CK(212) : AC(103), High Fructose Diet : CK(96) : AC(29), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099), Malondialdehyde Down-regulation : CK(554) : AC(152), Renoprotective : CK(572) : AC(254)

Curcumin may be useful to ameliorate lipid metabolism alterations and oxidative damage associated with hormone deprivation in menopause.

Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:5719291. Epub 2015 Nov 23. PMID: 26640615

Article Published Date : Dec 31, 2015

Authors : Maurilio da Silva Morrone, Carlos Eduardo Schnorr, Guilherme Antônio Behr, Juciano Gasparotto, Rafael Calixto Bortolin, Katia da Boit Martinello, Bernardo Saldanha Henkin, Thallita Kelly Rabello, Alfeu Zanotto-Filho, Daniel Pens Gelain, José Cláudio Fonseca Moreira

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Menopausal Syndrome : CK(295) : AC(45), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hypolipidemic : CK(1288) : AC(265)

Curcumin may inhibit oxidative stress including LDL cholesterol oxidation.

Pubmed Data : J Enzyme Inhib Med Chem. 2010 Oct;25(5):720-9. PMID: 20163327

Article Published Date : Oct 01, 2010

Authors : Hye-Sook Lee, Min-Ja Lee, Hyuck Kim, Sung-Kyu Choi, Jai-Eun Kim, Hyung-In Moon, Won-Hwan Park

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cholesterol: Oxidation : CK(518) : AC(117), Endothelial Dysfunction : CK(1210) : AC(237), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), NF-kappaB Inhibitor : CK(1114) : AC(694), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Curcumin may prevent oxidative insults to spermatozoa and thus preserve the functional activity of male gametes.

Pubmed Data : Anim Reprod Sci. 2016 Jun 21. Epub 2016 Jun 21. PMID: 27377223

Article Published Date : Jun 20, 2016

Authors : Eva Tvrdá, Eva Tušimová, Anton Kováčik, Dušan Paál, Hana Greifová, Abzal Abdramanov, Norbert Lukáč

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Oxidative Stress : CK(3871) : AC(1382), Sperm Quality: Low : CK(222) : AC(48)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Cytoprotective : CK(190) : AC(94)

Curcumin may protect rat HSCs against oxidative stress and inhibit the GO induced activation and secretion of ECM molecules in vitro.

Pubmed Data : Mol Med Rep. 2015 Dec 17. Epub 2015 Dec 17. PMID: 26676408

Article Published Date : Dec 16, 2015

Authors : Zhenxiong Liu, Weijia Dou, Yuanyuan Zheng, Qinsheng Wen, Ming Qin, Xuxia Wang, Hua Tang, Rong Zhang, Dandan Lv, Jingjie Wang, Shuguang Zhao

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Malondialdehyde Down-regulation : CK(554) : AC(152), Nrf2 activation : CK(177) : AC(86)

Curcumin may protect the aging brain from oxidative stress.

Pubmed Data : Int J Dev Neurosci. 2010 Aug;28(5):351-7. Epub 2010 Apr 18. PMID: 20403421

Article Published Date : Aug 01, 2010

Authors : Preeticia Dkhar, Ramesh Sharma

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Aging : CK(1658) : AC(438), Aging: Brain : CK(248) : AC(85), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Drug Synergy : CK(352) : AC(157)

Curcumin may represent a new horizon in managing iron overload-induced toxicity as well as in pathological diseases characterized by hepatic iron accumulation.

Pubmed Data : PLoS One. 2015 ;10(7):e0134156. Epub 2015 Jul 31. PMID: 26230491

Article Published Date : Dec 31, 2014

Authors : Farid A Badria, Ahmed S Ibrahim, Adel F Badria, Ahmed A Elmarakby

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Iron Overload : CK(32) : AC(18), Myelodysplastic Syndromes : CK(224) : AC(23), Oxidative Stress : CK(3871) : AC(1382), Sickle Cell Anemia : CK(192) : AC(22), Thalassemia : CK(106) : AC(15)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Iron Chelating Agents : CK(4) : AC(3)

Curcumin might be used as a preventive and therapeutic agent for treatment of cardiovascular diseases associated with oxidative stress.

Pubmed Data : Cell Biosci. 2017 ;7:20. Epub 2017 Apr 21. PMID: 28439402

Article Published Date : Dec 31, 2016

Authors : Xiaobo Yang, Hong Jiang, Yao Shi

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cardiovascular Diseases : CK(7342) : AC(916), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Cardioprotective : CK(1596) : AC(409), Heme oxygenase-1 inducer : CK(8) : AC(5)

Curcumin pretreatment is a promising adjuvant strategy for stem cells transplantation in myocardial restoration.

Pubmed Data : Stem Cells Int. 2015 ;2015:638153. Epub 2015 May 5. PMID: 26074974

Article Published Date : Dec 31, 2014

Authors : Jianfeng Liu, Ping Zhu, Peng Song, Weiping Xiong, Haixu Chen, Wenhui Peng, Shuxia Wang, Shan Li, Zhiqing Fu, Yutang Wang, Haibin Wang

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Ischemia: Myocardial : CK(50) : AC(21), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Angiogenesis Inducing Agents : CK(2) : AC(1), Anti-Apoptotic : CK(384) : AC(212), Antioxidants : CK(8430) : AC(3132), Heme oxygenase-1 up-regulation : CK(73) : AC(40)

Additional Keywords : Mesenchymal Stem Cells : CK(13) : AC(7)

Curcumin pretreatment protects against acute acrylonitrile-induced oxidative damage in rats.

Pubmed Data : Radiat Oncol. 2010 Nov 22;5(1):111. Epub 2010 Nov 22. PMID: 19913070

Article Published Date : Nov 22, 2010

Authors : Xing Guangwei, Lu Rongzhu, Xu Wenrong, Wang Suhua, Zhao Xiaowu, Wang Shizhong, Zhang Ye, Michael Aschner, Shrinivas K Kulkarni, Mahendra Bishnoi

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chemical Exposure: Acrylonitrile : CK(2) : AC(1), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin prevents advanced glycation induced complications of diabetes.

Pubmed Data : Biochem Pharmacol. 1998 Dec 15;56(12):1607-14. PMID: 9973181

Article Published Date : Dec 15, 1998

Authors : G B Sajithlal, P Chithra, G Chandrakasan

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : A1C : CK(277) : AC(35), Advanced Glycation End products (AGE) : CK(231) : AC(73), Diabetic Complications : CK(1563) : AC(333), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin prevents and reverses cirrhosis induced by bile duct obstruction.

Pubmed Data : Fundam Clin Pharmacol. 2008 Aug;22(4):417-27. PMID: 18705752

Article Published Date : Aug 01, 2008

Authors : Karina Reyes-Gordillo, José Segovia, Mineko Shibayama, Victor Tsutsumi, Paula Vergara, Mario G Moreno, Pablo Muriel

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Biliary Cirrhosis : CK(12) : AC(2), Cirrhosis : CK(348) : AC(49), Gallbladder Inflammation : CK(25) : AC(5), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin prevents forebrain ischemia-induced neuronal damage and oxidative insult in the rat hippocampus.

Pubmed Data : Neurochem Res. 2006 May;31(5):611-8. Epub 2006 May 23. PMID: 16770732

Article Published Date : May 01, 2006

Authors : Fadhel A Al-Omar, Mahmoud N Nagi, Mustafa M Abdulgadir, Khalda S Al Joni, Abdulhakeem A Al-Majed

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Injury: Hippocampal Damage : CK(39) : AC(18), Brain Ischemia : CK(136) : AC(52), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Apoptotic : CK(2958) : AC(2075), Enzyme Inhibitors : CK(473) : AC(251), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin prevents free radical-mediated cataractogenesis.

Pubmed Data : Free Radic Biol Med. 2010 Feb 15;48(4):483-92. Epub 2009 Dec 10. PMID: 19932168

Article Published Date : Feb 15, 2010

Authors : Ramar Manikandan, Raman Thiagarajan, Sivagnanam Beulaja, Ganapasam Sudhandiran, Munuswamy Arumugam

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cataract : CK(196) : AC(61), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin prevents selenite-induced cataractogenesis in rat pups.

Pubmed Data : Curr Eye Res. 2010 Feb;35(2):122-9. PMID: 20136422

Article Published Date : Feb 01, 2010

Authors : R Manikandan, R Thiagarajan, S Beulaja, G Sudhandiran, M Arumugam

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Vitamin C : CK(2484) : AC(569), Vitamin E : CK(1881) : AC(335)

Diseases : Cataract : CK(196) : AC(61), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Additional Keywords : Sodium Selenite : CK(49) : AC(19)

Curcumin protects 6-hydroxydopamine (6-OHDA)-induced neuronal death associated with Parkinson disease.

Pubmed Data : Biochem Pharmacol. 2009 Jul 15;78(2):178-83. Epub 2009 Apr 8. PMID: 19464433

Article Published Date : Jul 15, 2009

Authors : Jun Wang, Xi-Xun Du, Hong Jiang, Jun-Xia Xie

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Oxidative Stress : CK(3871) : AC(1382), Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Apoptotic : CK(2958) : AC(2075), Neuroprotective Agents : CK(2360) : AC(1099), NF-kappaB Inhibitor : CK(1114) : AC(694)

Curcumin protects against acute liver damage in the rat.

Pubmed Data : Biochim Biophys Acta. 2007 Jun;1770(6):989-96. Epub 2007 Feb 22. PMID: 17383825

Article Published Date : Jun 01, 2007

Authors : Karina Reyes-Gordillo, José Segovia, Mineko Shibayama, Paula Vergara, Mario G Moreno, Pablo Muriel

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chemically-Induced Liver Damage : CK(634) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099), NF-kappaB Inhibitor : CK(1114) : AC(694)

Curcumin protects against alcohol and PUFA-induced lipid peroxidation.

Pubmed Data : Phytother Res. 2003 Sep;17(8):925-9. PMID: 13680826

Article Published Date : Sep 01, 2003

Authors : R Rukkumani, M Sri Balasubashini, Venugopal P Menon

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alcohol Toxicity : CK(337) : AC(125), Hyperlipidemia : CK(670) : AC(155), Lipid Peroxidation : CK(695) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin protects against chemically-induced cataract formation in rat lenses.

Pubmed Data : Am J Clin Nutr. 1996 Nov;64(5):761-6. PMID: 8901798

Article Published Date : Nov 01, 1996

Authors : S Awasthi, S K Srivatava, J T Piper, S S Singhal, M Chaubey, Y C Awasthi

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cataract : CK(196) : AC(61), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin protects against chemically-induced oxidative stress in the brain.

Pubmed Data : Eur Rev Med Pharmacol Sci. 2006 Jul-Aug;10(4):157-61. PMID: 16910344

Article Published Date : Jul 01, 2006

Authors : A Rajeswari

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects against cisplatin-induced oxidative injury in rat testis.

Pubmed Data : Hum Reprod. 2009 Jul;24(7):1717-25. Epub 2009 Mar 11. PMID: 19279034

Article Published Date : Jul 01, 2009

Authors : Yusuf Ozlem Ilbey, Emin Ozbek, Mustafa Cekmen, Abdulmuttalip Simsek, Alper Otunctemur, Adnan Somay

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chemotherapy-Induced Toxicity : CK(1033) : AC(327), Chemotherapy-Induced Toxicity: Cisplatin : CK(319) : AC(133), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), NF-kappaB Inhibitor : CK(1114) : AC(694)

Additional Keywords : Drug: Cisplatin : CK(49) : AC(18)

Curcumin protects against hydrogen peroxide induced cytotoxicity.

Pubmed Data : Hum Exp Toxicol. 2010 May 20. Epub 2010 May 20. PMID: 20488840

Article Published Date : May 20, 2010

Authors : M A Siddiqui, M P Kashyap, V Kumar, V K Tripathi, V K Khanna, S Yadav, A B Pant

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Cytoprotective : CK(190) : AC(94)

Curcumin protects against methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells.

Pubmed Data : Acta Pharmacol Sin. 2006 Sep;27(9):1192-8. PMID: 16923340

Article Published Date : Sep 01, 2006

Authors : Wen-hsiung Chan, Hsin-jung Wu

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : DNA damage : CK(1017) : AC(387), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Apoptotic : CK(2958) : AC(2075)

Curcumin protects against nicotine-induced lung toxicity by modulating the extent of lipid peroxidation and augmenting antioxidant defense system.

Pubmed Data : Pol J Pharmacol. 2004 Sep-Oct;56(5):581-6. PMID: 15591646

Article Published Date : Sep 01, 2004

Authors : C Kalpana, V P Menon

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Lipid Peroxidation : CK(695) : AC(255), Nicotine/Tobacco Toxicity : CK(118) : AC(40), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin protects against oxidative insult induced by pentylenetetrazol in epileptic rats.

Pubmed Data : Methods Find Exp Clin Pharmacol. 2010 May;32(4):227-32. PMID: 20508869

Article Published Date : May 01, 2010

Authors : V Sharma, B Nehru, A Munshi, A Jyothy

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Piperidines : CK(59) : AC(22)

Diseases : Drug-Induced Toxicity: Epilepsy Drugs : CK(2) : AC(1), Epilepsy : CK(255) : AC(66), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Drug Synergy : CK(352) : AC(157)

Curcumin reduces indomethacin-induced damage in the rat small intestine.

Pubmed Data : Cancer Res. 2010 Nov 15;70(22):9218-23. Epub 2010 Oct 26. PMID: 17351913

Article Published Date : Nov 15, 2010

Authors : Nageswaran Sivalingam, Raghunath Hanumantharaya, Minnie Faith, Jayasree Basivireddy, K A Balasubramanian, Molly Jacob

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Duodenal Ulcer : CK(89) : AC(26), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Ulcer Agents : CK(213) : AC(84), Antioxidants : CK(8430) : AC(3132)

Additional Keywords : Drug: Indomethacin : CK(43) : AC(24)

curcumin reduces markers of liver damage in rats treated with heated sunflower oil or ethanol.

Pubmed Data : Vet Ital. 2010 Jan-Mar;46(1):83-92. PMID: 20391370

Article Published Date : Jan 01, 2010

Authors : Nasr A M N El-Deen, Mohamed Eid

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alcohol Toxicity : CK(337) : AC(125), Liver Damage: Drug-Induced : CK(95) : AC(27), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099)

Curcumin showed significant amelioration in all genotoxic and oxidative stress-related indices.

Pubmed Data : Drug Chem Toxicol. 2017 Feb 1:1-8. Epub 2017 Feb 1. PMID: 28147706

Article Published Date : Jan 31, 2017

Authors : Ankit Nariya, Ambar Pathan, Naumita Shah, Shiva Chettiar, Alpesh Patel, Jignasha Dattani, Divya Chandel, Mandava Rao, Devendrasinh Jhala

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Lead Poisoning : CK(205) : AC(60), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Genoprotective : CK(270) : AC(97)

Problem Substances : Lead : CK(167) : AC(32)

Curcumin significantly reduces lipid peroxidation associated with diabetes.

Pubmed Data : J Cardiovasc Pharmacol. 2005 Nov;46(5):697-705. PMID: 16220078

Article Published Date : Nov 01, 2005

Authors : Jayesh B Majithiya, R Balaraman

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Diabetes: Cardiovascular Illness : CK(700) : AC(107), Lipid Peroxidation : CK(695) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin strongly induced modulator effects on oxidative stress, intracellular Ca2+ levels, and the caspase-3 and -9 values in an experimental oxidative stress model.

Pubmed Data : J Recept Signal Transduct Res. 2015 Nov 25:1-7. Epub 2015 Nov 25. PMID: 26608462

Article Published Date : Nov 24, 2015

Authors : Abdülhadi Cihangir Uğuz, Ahmi Öz, Mustafa Nazıroğlu

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Oxidative Stress : CK(3871) : AC(1382), Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin supplementation can attenuate exercise-induced oxidative stress by increasing blood antioxidant capacity.

Pubmed Data : Int J Sports Med. 2014 Jun ;35(6):469-75. Epub 2013 Oct 28. PMID: 24165958

Article Published Date : May 31, 2014

Authors : M Takahashi, K Suzuki, H K Kim, Y Otsuka, A Imaizumi, M Miyashita, S Sakamoto

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Oxidative Stress : CK(3871) : AC(1382)

Therapeutic Actions : Exercise : CK(1278) : AC(196)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Superoxide Dismutase Up-regulation : CK(530) : AC(174)

Curcumin supplementation to aluminum treated rats was able to normalize significantly the activities of all the three mitochondrial complexes.

Pubmed Data : Neurotox Res. 2011 Nov ;20(4):351-61. Epub 2011 Jun 9. PMID: 21656326

Article Published Date : Oct 31, 2011

Authors : Pooja Khanna Sood, Uma Nahar, Bimla Nehru

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Aluminum Toxicity : CK(207) : AC(75), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Problem Substances : Aluminum : CK(274) : AC(78)

Curcumin suppresses chemically-induced oxidative stress in the mouse liver.

Pubmed Data : Prog Biophys Mol Biol. 2007 Jan-Apr;93(1-3):295-300. Epub 2006 Aug 22. PMID: 11234915

Article Published Date : Jan 01, 2007

Authors : S Watanabe, T Fukui

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chemically-Induced Liver Damage : CK(634) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Enzyme Inhibitors : CK(473) : AC(251), Hepatoprotective : CK(2523) : AC(1099)

Curcumin treatment protects against oxidative stress in streptozotocin-induced diabetic rats.

Pubmed Data : J Med Food. 2005;8(2):251-5. PMID: 16117620

Article Published Date : Jan 01, 2005

Authors : T Mahesh, M Sri Balasubashini, Venugopal P Menon

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Diabetes: Oxidative Stress : CK(131) : AC(40), Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Lipid Peroxidation : CK(695) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hypoglycemic Agents : CK(1446) : AC(342)

Curcumin was shown to have positive effects on lifespan extension in animal studies.

Pubmed Data : Biofactors. 2013 Jan-Feb;39(1):133-40. Epub 2013 Jan 17. PMID: 23325575

Article Published Date : Dec 31, 2012

Authors : Li-Rong Shen, Laurence D Parnell, Jose M Ordovas, Chao-Qiang Lai

Study Type : Animal Study, Insect Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Tetrahydrocurcumin : CK(80) : AC(39)

Diseases : Aging : CK(1658) : AC(438), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Superoxide Dismutase Up-regulation : CK(530) : AC(174)

Additional Keywords : Gene Expression Regulation : CK(431) : AC(214), Longevity : CK(2) : AC(1)

Curcumin works synergistically with celecoxib to potentiate a growth-inhibitory and pro-apoptotic in osteoarthritis synovial adherent cells.

Pubmed Data : Rheumatology (Oxford). 2006 Feb;45(2):171-7. Epub 2005 Oct 25. PMID: 16249246

Article Published Date : Feb 01, 2006

Authors : S Lev-Ari, L Strier, D Kazanov, O Elkayam, D Lichtenberg, D Caspi, N Arber

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Osteoarthritis: Knee : CK(517) : AC(53), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075), Cyclooxygenase 1 Inhibitor : CK(34) : AC(27), Cyclooxygenase 2 Inhibitors : CK(464) : AC(272)

Additional Keywords : Drug: Celecoxib : CK(2) : AC(2), Drug Synergy : CK(352) : AC(157)

Curcumin works synergistically with drugs as an anti-fibrotic agent in liver fibrosis.

Pubmed Data : Zhong Yao Cai. 2003 Nov;26(11):795-8. PMID: 14989060

Article Published Date : Nov 01, 2003

Authors : Weifeng Yang, Houchang Chen, Yiping Jiang

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Liver Fibrosis : CK(246) : AC(104), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Antiproliferative : CK(2546) : AC(1685)

Additional Keywords : Drug Synergy : CK(352) : AC(157)

Curcumin's induction of enzymes involved in the detoxification of the electrophilic products of lipid peroxidation may contribute to the anti-inflammatory and anti-cancer activities of curcumin.

Pubmed Data : Int J Biochem Cell Biol. 1998 Apr;30(4):445-56. PMID: 9675878

Article Published Date : Apr 01, 1998

Authors : J T Piper, S S Singhal, M S Salameh, R T Torman, Y C Awasthi, S Awasthi

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Inflammation : CK(3240) : AC(882), Lipid Peroxidation : CK(695) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antineoplastic Agents : CK(1158) : AC(639), Antioxidants : CK(8430) : AC(3132), Detoxifier : CK(408) : AC(131)

Curcumin, capsaicin and garlic inhibit adverse blood and liver changes associated wtih a high-fat diet in rats.

Pubmed Data : Ann Nutr Metab. 2004 Sep-Oct;48(5):314-20. Epub 2004 Oct 1. PMID: 15467281

Article Published Date : Sep 01, 2004

Authors : R K Kempaiah, K Srinivasan

Study Type : Animal Study

Additional Links

Substances : Capsaicin : CK(141) : AC(57), Curcumin : CK(4417) : AC(2300), Garlic : CK(824) : AC(274)

Diseases : Hyperlipidemia : CK(670) : AC(155), Liver Disease : CK(145) : AC(41), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099)

Curcumin, ellagic acid and bixin attenuate radiation induced toxicity.

Pubmed Data : Indian J Exp Biol. 1996 Sep;34(9):845-7. PMID: 9014516

Article Published Date : Sep 01, 1996

Authors : K C Thresiamma, J George, R Kuttan

Study Type : Animal Study

Additional Links

Substances : Bixin : CK(7) : AC(4), Carotenoids : CK(1796) : AC(356), Curcumin : CK(4417) : AC(2300), Ellagic Acid : CK(141) : AC(71)

Diseases : Oxidative Stress : CK(3871) : AC(1382), Radiation Induced Illness : CK(1048) : AC(265)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Radioprotective : CK(858) : AC(293)

Curcumin, resveratrol and melatonin protect against cadmium-induced oxidative damage.

Pubmed Data : Toxicology. 2006 Aug 15;225(2-3):150-6. Epub 2006 May 26. PMID: 16806632

Article Published Date : Aug 15, 2006

Authors : Vladislav Eybl, Dana Kotyzova, Jaroslav Koutensky

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Melatonin : CK(1194) : AC(394), Resveratrol : CK(1511) : AC(865)

Diseases : Cadmium Poisoning : CK(131) : AC(62), Lipid Peroxidation : CK(695) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Additional Keywords : Stilbenes : CK(402) : AC(242)

Curcumin-manganese complexes have enhanced antioxidant activity.

Pubmed Data : Free Radic Biol Med. 2003 Dec 15;35(12):1632-44. PMID: 14680686

Article Published Date : Dec 15, 2003

Authors : Opa Vajragupta, Preecha Boonchoong, Hiroshi Watanabe, Michihisa Tohda, Naparat Kummasud, Yaowared Sumanont

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Manganese : CK(15) : AC(4)

Diseases : Lipid Peroxidation : CK(695) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Natural Substance Synergy : CK(540) : AC(249)

Curcuminoids have anti-tumor and antioxidant activity.

Pubmed Data : Cancer Lett. 1995 Jul 20;94(1):79-83. PMID: 7621448

Article Published Date : Jul 20, 1995

Authors : A J Ruby, G Kuttan, K D Babu, K N Rajasekharan, R Kuttan

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Breast Cancer : CK(3592) : AC(1064), Oxidative Stress : CK(3871) : AC(1382), Tumors : CK(205) : AC(120)

Pharmacological Actions : Anti-Tumor : CK(146) : AC(73), Antioxidants : CK(8430) : AC(3132)

Curcuminoids may be used to ameliorate oxidative damage in patients with beta-thalassemia/Hb E disease.

Pubmed Data : Clin Biochem. 2010 Mar;43(4-5):424-9. Epub 2009 Nov 10. PMID: 19900435

Article Published Date : Mar 01, 2010

Authors : Ruchaneekorn W Kalpravidh, Noppadol Siritanaratkul, Praphaipit Insain, Ratiya Charoensakdi, Narumol Panichkul, Suneerat Hatairaktham, Somdet Srichairatanakool, Chada Phisalaphong, Eliezer Rachmilewitz, Suthat Fucharoen

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Hemoglobinopathies : CK(20) : AC(2), Oxidative Stress : CK(3871) : AC(1382), Thalassemia : CK(106) : AC(15)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Enzyme Inhibitors : CK(473) : AC(251)

Curcuminoids positively modulates oxidative damage and mitochondrial dysfunction in diabetic rat brain.

Pubmed Data : Free Radic Res. 2008 Nov;42(11-12):999-1005. PMID: 19031318

Article Published Date : Nov 01, 2008

Authors : Manisha Rastogi, Rudra P Ojha, G V Rajamanickam, Aruna Agrawal, Abha Aggarwal, G P Dubey

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Flavonoids : CK(1215) : AC(379), Polyphenols : CK(1109) : AC(390)

Diseases : Diabetes: Cognitive Dysfunction : CK(40) : AC(17), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Dietary curcumin ameliorates aging-related cerebrovascular dysfunction through the AMPK/uncoupling protein 2 pathway.

Pubmed Data : Cell Physiol Biochem. 2013 ;32(5):1167-77. Epub 2013 Nov 11. PMID: 24335167

Article Published Date : Dec 31, 2012

Authors : Yunfei Pu, Hexuan Zhang, Peijian Wang, Yu Zhao, Qiang Li, Xing Wei, Yuanting Cui, Jing Sun, Qianhui Shang, Daoyan Liu, Zhiming Zhu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Inflammation : CK(274) : AC(145), Cerebrovascular Disorders : CK(32) : AC(4), Ischemia : CK(76) : AC(38), Neurodegenerative Diseases : CK(3582) : AC(932), Oxidative Stress : CK(3871) : AC(1382), Stroke : CK(1365) : AC(168)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099), Neurorestorative : CK(71) : AC(21)

EGCG and curcumin suppress Alzheimer disease associated beta amyloid production.

Pubmed Data : Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H715-21. Epub 2005 Mar 18. PMID: 18695518

Article Published Date : Aug 01, 2005

Authors : Yoshiari Shimmyo, Takeshi Kihara, Akinori Akaike, Tetsuhiro Niidome, Hachiro Sugimoto

Study Type : In Vitro Study

Additional Links

Substances : Catechin : CK(522) : AC(170), Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Enzyme Inhibitors : CK(473) : AC(251), Neuroprotective Agents : CK(2360) : AC(1099)

Embelin and curcumin have a beneficial effect against oxidative tissue damage during chemically-induced hepatocarinogenesis in rats.

Pubmed Data : Mol Cell Biochem. 2006 Mar;284(1-2):49-55. Epub 2006 Feb 14. PMID: 16477385

Article Published Date : Mar 01, 2006

Authors : Meenakshisundaram Sreepriya, Geetha Bali

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Embelia ribes : CK(16) : AC(8)

Diseases : Chemically-Induced Liver Damage : CK(634) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099)

Additional Keywords : Drug Synergy : CK(352) : AC(157)

Experimental data supports the bright future of natural polyphenols as anticancer tools.

Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:6475624. Epub 2015 Nov 16. PMID: 26649142

Article Published Date : Dec 31, 2015

Authors : Anna Maria Mileo, Stefania Miccadei

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), EGCG (Epigallocatechin gallate) : CK(721) : AC(380), Genistein : CK(578) : AC(252), Polyphenols : CK(1109) : AC(390), Resveratrol : CK(1511) : AC(865), Sulforaphane : CK(624) : AC(303)

Diseases : Cancers: All : CK(14773) : AC(4596), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075), Chemopreventive : CK(2835) : AC(787)

Additional Keywords : Epigenetic Modification In Cancer : CK(65) : AC(32)

Melatonin, curcumin, quercetin, and resveratrol ameliorate chemically-induced kidney damage.

Pubmed Data : Neuro Endocrinol Lett. 2007 Dec;28(6):739-44. PMID: 18684806

Article Published Date : Dec 01, 2007

Authors : V Eybl, D Kotyzová, P Cerná, J Koutensky

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Melatonin : CK(1194) : AC(394), Quercetin : CK(716) : AC(335), Resveratrol : CK(1511) : AC(865)

Diseases : Kidney Damage : CK(193) : AC(64), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Renoprotective : CK(572) : AC(254)

Additional Keywords : Stilbenes : CK(402) : AC(242)

Meta-analysis of randomized controlled trials of 4 weeks or longer suggest that curcumin may afford some protection against oxidative stress.

Pubmed Data : Nutr Res. 2018 12 ;60:1-12. Epub 2018 Sep 4. PMID: 30527253

Article Published Date : Jan 11, 2018

Authors : Si Qin, Lifan Huang, Jiaojiao Gong, Shasha Shen, Juan Huang, Yao Tang, Hong Ren, Huaidong Hu

Study Type : Meta Analysis

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Malondialdehyde Down-regulation : CK(554) : AC(152)

NAC and curcumin protect against malathion-induced toxicity in human peripheral blood mononuclear cells.

Pubmed Data : Toxicol In Vitro. 2009 Oct;23(7):1319-25. Epub 2009 Jul 14. PMID: 19607909

Article Published Date : Oct 01, 2009

Authors : Tanzeel Ahmed, Ashok K Tripathi, Sanvidhan G Suke, Vivek Kumar, Rafat S Ahmed, Shukla Das, Basu Dev Banerjee

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), NAC (N-acetyl-L-cysteine) : CK(318) : AC(76)

Diseases : Oxidative Stress : CK(3871) : AC(1382), Pesticide Toxicity : CK(192) : AC(61)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Apoptotic : CK(2958) : AC(2075)

Piperine displays the more anti-oxidative, anti-apoptotic and chemo-protective properties in the DLM induced splenic apoptosis as compared to curcumin.

Pubmed Data : Pestic Biochem Physiol. 2015 Mar ;119:16-27. Epub 2015 Mar 10. PMID: 25868812

Article Published Date : Feb 28, 2015

Authors : Anoop Kumar, Neelima Sharma

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Piperine : CK(169) : AC(84)

Diseases : Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Antioxidants : CK(8430) : AC(3132)

Problem Substances : Deltamethrin : CK(3) : AC(2)

Pretreatment with curcumin induces Nrf2 and an antioxidant response that may play an important role in the protective effect of this antioxidant against hemin-induced neuronal death.

Pubmed Data : Oxid Med Cell Longev. 2013 ;2013:801418. Epub 2013 Dec 22. PMID: 24454990

Article Published Date : Dec 31, 2012

Authors : Susana González-Reyes, Silvia Guzmán-Beltrán, Omar Noel Medina-Campos, José Pedraza-Chaverri

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Heme oxygenase-1 up-regulation : CK(73) : AC(40), Neuroprotective Agents : CK(2360) : AC(1099), Nrf2 activation : CK(177) : AC(86), Superoxide Dismutase Up-regulation : CK(530) : AC(174)

Quercetin and curcumin protect against paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat.

Pubmed Data : Food Chem Toxicol. 2010 Nov;48(11):3246-61. Epub 2010 Sep 4. PMID: 20804811

Article Published Date : Nov 01, 2010

Authors : Mokhtar I Yousef, Sahar A M Omar, Marwa I El-Guendi, Laila A Abdelmegid

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Quercetin : CK(716) : AC(335)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(166) : AC(61), Chemically-Induced Liver Damage : CK(634) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099), Renoprotective : CK(572) : AC(254)

Sulforaphane and curcumin protect against malathion toxicity.

Pubmed Data : Eur Rev Med Pharmacol Sci. 2012 Jul ;16 Suppl 3:144-8. PMID: 22957429

Article Published Date : Jun 30, 2012

Authors : H Alp, I Aytekin, N K Hatipoglu, A Alp, M Ogun

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Sulforaphane : CK(624) : AC(303)

Diseases : Malathion Toxicity : CK(2) : AC(1), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Synergistic effect of black tea and curcumin in improving the hepatotoxicity induced by aflatoxin B1.

Pubmed Data : Toxicol Ind Health. 2015 Dec ;31(12):1269-80. Epub 2013 Jun 24. PMID: 23796760

Article Published Date : Nov 30, 2015

Authors : Abeer A Alm-Eldeen, Mohamed H Mona, Ali A Shati, Haitham I El-Mekkawy

Study Type : Animal Study

Additional Links

Substances : Black Tea : CK(366) : AC(85), Curcumin : CK(4417) : AC(2300)

Diseases : Lipid Peroxidation : CK(695) : AC(255), Liver Damage: Aflatoxin-Induced : CK(35) : AC(15), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099)

Additional Keywords : Natural Substance Synergy : CK(540) : AC(249)

Problem Substances : Aflatoxin : CK(56) : AC(8)

Tetrahydrocurcumin ameliorates tacrolimus-induced nephrotoxicity via inhibiting apoptosis.

Pubmed Data : Transplant Proc. 2018 Nov ;50(9):2854-2859. Epub 2018 Mar 16. PMID: 30401411

Article Published Date : Oct 31, 2018

Authors : C S Park, H J Jang, J H Lee, M Y Oh, H J Kim

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Tetrahydrocurcumin : CK(80) : AC(39)

Diseases : Kidney Damage: Chemically-Induced : CK(25) : AC(13), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Antioxidants : CK(8430) : AC(3132), Renoprotective : CK(572) : AC(254)

Tetrahydrocurcumin and rutin have cardioprotective properties in a rat model of myocardial infarction

Pubmed Data : Pharmazie. 2009 Feb;64(2):132-6. PMID: 19320287

Article Published Date : Feb 01, 2009

Authors : Md Sultan Ali, M P Mudagal, D Goli

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Rutin : CK(180) : AC(75), Tetrahydrocurcumin : CK(80) : AC(39)

Diseases : Myocardial Infarction : CK(1101) : AC(162), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Cardioprotective : CK(1596) : AC(409)

Tetrahydrocurcumin protect against radiation-induced lipid peroxidation.

Pubmed Data : Appl Physiol Nutr Metab. 2009 Dec;34(6):1093-7. PMID: 10803946

Article Published Date : Dec 01, 2009

Authors : S M Khopde, K I Priyadarsini, S N Guha, J G Satav, P Venkatesan, M N Rao

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Tetrahydrocurcumin : CK(80) : AC(39)

Diseases : Lipid Peroxidation : CK(695) : AC(255), Oxidative Stress : CK(3871) : AC(1382), Radiation Induced Illness : CK(1048) : AC(265)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Tetrahydrocurcumin protects against oxidative damage associated with chemical exposure.

Pubmed Data : Basic Clin Pharmacol Toxicol. 2006 Nov;99(5):329-34. PMID: 17076682

Article Published Date : Nov 01, 2006

Authors : Leelavinothan Pari, Pidaran Murugan

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Kidney Damage : CK(193) : AC(64), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Renoprotective : CK(572) : AC(254)

Tetrahydrocurcumin protects against oxidative stress in cholesterol-fed rabbits.

Pubmed Data : J Atheroscler Thromb. 2002;9(5):243-50. PMID: 12409634

Article Published Date : Jan 01, 2002

Authors : Michitaka Naito, Xiaohong Wu, Hideki Nomura, Michiteru Kodama, Yuriko Kato, Yoji Kato, Toshihiko Osawa

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Tetrahydrocurcumin : CK(80) : AC(39)

Diseases : Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Tetrahydrocurcumin protectsagainst erythromycin estolate-induced lipid peroxidation in rats.

Pubmed Data : J Basic Clin Physiol Pharmacol. 2005;16(1):1-15. PMID: 16187483

Article Published Date : Jan 01, 2005

Authors : Pidaran Murugan, Leelavinothan Pari

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Tetrahydrocurcumin : CK(80) : AC(39)

Diseases : Antibiotic Toxicity : CK(63) : AC(16), Lipid Peroxidation : CK(695) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anticarcinogenic Agents : CK(1099) : AC(519), Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099)

Additional Keywords : Drug: Erythromycin : CK(2) : AC(1)

The objective of this review is to provide information pertaining to various antioxidants found in food that have demonstrated utility in improving liver diseases.

Pubmed Data : World J Gastrointest Pharmacol Ther. 2015 Aug 6 ;6(3):59-72. PMID: 26261734

Article Published Date : Aug 05, 2015

Authors : Sael Casas-Grajales, Pablo Muriel

Study Type : Review

Additional Links

Substances : Coffee : CK(1102) : AC(133), Curcumin : CK(4417) : AC(2300), Naringenin : CK(90) : AC(54), Quercetin : CK(716) : AC(335), Resveratrol : CK(1511) : AC(865), Silymarin : CK(241) : AC(53)

Diseases : Liver Diseases : CK(53) : AC(13), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

These findings for the first time demonstrate that the neuromodulatory propensity of geraniol is indeed comparable to that of curcumin.

Pubmed Data : Chem Biol Interact. 2014 Nov 5 ;223:27-37. Epub 2014 Sep 6. PMID: 25199698

Article Published Date : Nov 04, 2014

Authors : Sathya N Prasad, Muralidhara

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Geraniol : CK(54) : AC(28)

Diseases : Acrylamide-induced toxicity : CK(16) : AC(9), Neurodegenerative Diseases : CK(3582) : AC(932), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Problem Substances : Acrylamide : CK(33) : AC(3)

These studies show that ultrasoluble curcumin and turmeric could prove useful as a therapeutic intervention in systemic lupus erythematosus and Sjogren's syndrome.

Pubmed Data : Lupus Sci Med. 2015 ;2(1):e000114. Epub 2015 Sep 8. PMID: 26380101

Article Published Date : Dec 31, 2014

Authors : Biji T Kurien, Valerie M Harris, Syed M S Quadri, Patricia Coutinho-de Souza, Joshua Cavett, Amanda Moyer, Bilal Ittiq, Angela Metcalf, Husayn F Ramji, Dat Truong, Ramesh Kumar, Kristi A Koelsch, Mike Centola, Adam Payne, Debashish Danda, R Hal Scofield

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Turmeric : CK(5583) : AC(2569)

Diseases : Lupus Erythematosus: Systemic : CK(486) : AC(69), Lymphadenopathy : CK(4) : AC(2), Oxidative Stress : CK(3871) : AC(1382), Proteinuria : CK(103) : AC(20), Sjogren's Syndrome : CK(88) : AC(18)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Renoprotective : CK(572) : AC(254)

Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Turmeric and curcumin appear to be beneficial in preventing diabetes-induced oxidative stress in rats.

Pubmed Data : Med Sci Monit. 2007 Dec;13(12):BR286-92. PMID: 18049430

Article Published Date : Dec 01, 2007

Authors : Palla Suryanarayana, Alleboena Satyanarayana, Nagalla Balakrishna, Putcha Uday Kumar, Geereddy Bhanuprakash Reddy

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Turmeric : CK(5583) : AC(2569)

Diseases : Diabetes: Oxidative Stress : CK(131) : AC(40), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Turmeric prevents oxidative stress induced kidney cell damage.

Pubmed Data : Free Radic Biol Med. 1998 Jan 1;24(1):49-54. PMID: 9436613

Article Published Date : Jan 01, 1998

Authors : H H Cohly, A Taylor, M F Angel, A K Salahudeen

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Turmeric : CK(5583) : AC(2569)

Diseases : Kidney Damage : CK(193) : AC(64), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Renoprotective : CK(572) : AC(254)

Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Turmeric reduces oxidative stress and attenuates aortic fatty streak development in rabbits.

Pubmed Data : Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1225-31. PMID: 12117742

Article Published Date : Jul 01, 2002

Authors : José L Quiles, M Dolores Mesa, César L Ramírez-Tortosa, Concepción M Aguilera, Maurizio Battino, Angel Gil, M Carmen Ramírez-Tortosa

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Turmeric : CK(5583) : AC(2569)

Diseases : Aortic Plaques : CK(27) : AC(10), Arteriosclerosis : CK(452) : AC(126), Cholesterol: Oxidation : CK(518) : AC(117), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Cardioprotective : CK(1596) : AC(409)

Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Various antioxidants may ameliorate napthalene-induced toxicity.

Pubmed Data : Toxicology. 2002 Oct 30;180(1):97-105. PMID: 12324202

Article Published Date : Oct 30, 2002

Authors : Sidney J Stohs, Sunny Ohia, Debasis Bagchi

Study Type : Commentary

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Cysteine (see N-Acetylcysteine) : CK(60) : AC(13), Melatonin : CK(1194) : AC(394), Vitamin E : CK(1881) : AC(335)

Diseases : Napthalene-Induced Toxicity : CK(3) : AC(2), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Water-soluble antioxidants improve the antioxidant and anticancer activity of low concentrations of curcumin in human leukemia cells.

Pubmed Data : Pharmazie. 2005 Jan;60(1):57-61. PMID: 15700780

Article Published Date : Jan 01, 2005

Authors : Jie Chen, Da Wanming, Dawei Zhang, Qing Liu, Jiuhong Kang

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), NAC (N-acetyl-L-cysteine) : CK(318) : AC(76), Vitamin C : CK(2484) : AC(569)

Diseases : Leukemia : CK(1005) : AC(398), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antineoplastic Agents : CK(1158) : AC(639), Antioxidants : CK(8430) : AC(3132), Antiproliferative : CK(2546) : AC(1685)

Additional Keywords : Bioavailability : CK(195) : AC(37), Natural Substance Synergy : CK(540) : AC(249)

Curcumin displays therapeutic activity in experimental studies of acute and chronic diseases characterized by an exaggerated inflammatory reaction.

Pubmed Data : Horm Behav. 1978 Feb;10(1):54-60. PMID: 16387899

Article Published Date : Feb 01, 1978

Authors : Stig Bengmark

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Inflammation : CK(3240) : AC(882)

Pharmacological Actions : Antineoplastic Agents : CK(1158) : AC(639), Antioxidants : CK(8430) : AC(3132), Cyclooxygenase 2 Inhibitors : CK(464) : AC(272), Enzyme Inhibitors : CK(473) : AC(251)

Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity.

Pubmed Data : Endocrinology. 2008 Jul;149(7):3549-58. Epub 2008 Apr 10. PMID: 18403477

Article Published Date : Jul 01, 2008

Authors : Stuart P Weisberg, Rudolph Leibel, Drew V Tortoriello

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Adiponectin: Low Levels : CK(118) : AC(27), Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Inflammation : CK(3240) : AC(882), Obesity : CK(2443) : AC(521)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Interleukin-6 Downregulation : CK(1137) : AC(354), NF-kappaB Inhibitor : CK(1114) : AC(694), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Tea, rosemary and turmeric inhibit inflammation.

Pubmed Data : Cancer Lett. 1995 Sep 4;96(1):23-9. PMID: 7553604

Article Published Date : Sep 04, 1995

Authors : M M Chan, C T Ho, H I Huang

Study Type : In Vitro Study

Additional Links

Substances : Catechin : CK(522) : AC(170), Curcumin : CK(4417) : AC(2300), Rosemary : CK(237) : AC(91), Tea : CK(2180) : AC(455)

Diseases : Inflammation : CK(3240) : AC(882), Lipopolysaccharide-Induced Toxicity : CK(380) : AC(218)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Nitric Oxide Inhibitor : CK(223) : AC(108), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin exhibits anti-metastatic properties in breast cancer cells.

Pubmed Data : Carcinogenesis. 2008 Apr;29(4):779-89. Epub 2007 Nov 13. PMID: 17999991

Article Published Date : Apr 01, 2008

Authors : Beatrice E Bachmeier, Isabelle V Mohrenz, Valentina Mirisola, Erwin Schleicher, Francesco Romeo, Clara Höhneke, Marianne Jochum, Andreas G Nerlich, Ulrich Pfeffer

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Breast Cancer : CK(3592) : AC(1064), Cancer Metastasis : CK(442) : AC(206)

Pharmacological Actions : Anti-metastatic : CK(634) : AC(414), Antioxidants : CK(8430) : AC(3132), NF-kappaB Inhibitor : CK(1114) : AC(694)

Curcumin exhibits chemopreventive properties against cholangiocarcinoma cells.

Pubmed Data : Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2265-72. Epub 2010 May 25. PMID: 20510329

Article Published Date : Aug 01, 2010

Authors : Bunliang Suphim, Auemduan Prawan, Upa Kukongviriyapan, Sarinya Kongpetch, Benjaporn Buranrat, Veerapol Kukongviriyapan

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cholangiocarcinoma : CK(96) : AC(21)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075), Chemopreventive : CK(2835) : AC(787), NF-kappaB Inhibitor : CK(1114) : AC(694)

Curcumin exhibits inhibitory effects liver fibrosis associated with injury.

Pubmed Data : Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G20-30. Epub 2003 Mar 26. PMID: 12660143

Article Published Date : Jul 01, 2003

Authors : Jianye Xu, Yumei Fu, Anping Chen

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Liver Fibrosis : CK(246) : AC(104)

Pharmacological Actions : Antineoplastic Agents : CK(1158) : AC(639), Antioxidants : CK(8430) : AC(3132), Antiproliferative : CK(2546) : AC(1685), Hepatoprotective : CK(2523) : AC(1099), NF-kappaB Inhibitor : CK(1114) : AC(694)

Additional Keywords : Drug Synergy : CK(352) : AC(157)

Curcumin prevents diabetes-associated abnormalities in the kidneys.

Pubmed Data : Nutrition. 2009 Sep;25(9):964-72. Epub 2009 Mar 5. PMID: 19268536

Article Published Date : Sep 01, 2009

Authors : Jane Chiu, Zia A Khan, Hana Farhangkhoee, Subrata Chakrabarti

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), NF-kappaB Inhibitor : CK(1114) : AC(694), Renoprotective : CK(572) : AC(254)

Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Curcumin prevents shock-wave lithotripsy-induced renal injury.

Pubmed Data : Urol Res. 2009 Jun;37(3):159-64. Epub 2009 Apr 2. PMID: 19340419

Article Published Date : Jun 01, 2009

Authors : Muzaffer Bas, Volkan Tugcu, Eray Kemahli, Emin Ozbek, Mehmet Uhri, Tuncay Altug, Ali I Tasci

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Kidney Stones : CK(180) : AC(32), Shock wave lithotripsy (SWL)-induced damage : CK(2) : AC(1)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), NF-kappaB Inhibitor : CK(1114) : AC(694), Nitric Oxide Inhibitor : CK(223) : AC(108)

Curcumin abrogated cancer associated fibroblast induced invasion and EMT, and inhibited ROS production and CXCR4 and IL-6 receptor expression in prostate cancer cells.

Pubmed Data : Int J Oncol. 2015 Oct 13. Epub 2015 Oct 13. PMID: 26499200

Article Published Date : Oct 12, 2015

Authors : Yuefeng Du, Qingzhi Long, Lin Zhang, Ying Shi, Xioagang Liu, Xudong Li, Bin Guan, Yanchao Tian, Xinyang Wang, Lei Li, Dalin He

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Prostate Cancer : CK(1586) : AC(463)

Pharmacological Actions : Anti-metastatic : CK(634) : AC(414), Antioxidants : CK(8430) : AC(3132), Chemotherapeutic : CK(397) : AC(152)

Curcumin and NAC protect against valproate-induced liver toxicity.

Pubmed Data : Arzneimittelforschung. 2010;60(11):647-53. PMID: 21175036

Article Published Date : Jan 01, 2010

Authors : Shehta Abd-Allah Said, Dina Saad El-Agamy

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), NAC (N-acetyl-L-cysteine) : CK(318) : AC(76)

Diseases : Chemically-Induced Liver Damage : CK(634) : AC(255), Drug-Induced Toxicity: Valproic Acid (Depakote) : CK(4) : AC(2)

Pharmacological Actions : Anticonvulsants : CK(238) : AC(67), Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099)

Curcumin is a nitric oxide scavenger.

Pubmed Data : Gynecol Oncol. 2004 Sep;94(3):760-8. PMID: 9120760

Article Published Date : Sep 01, 2004

Authors : Sreejayan, M N Rao

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Nitric Oxide Inhibitor : CK(223) : AC(108)

Curcumin and NAC prevent fatty acid changes produced by ethanol and also reduce the inflammatory response of ethanol by reducing the level of prostaglandins.

Pubmed Data : Pain. 2005 Mar;114(1-2):266-77. Epub 2005 Jan 26. PMID: 11504446

Article Published Date : Mar 01, 2005

Authors : V R Akrishnan, V P Menon

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), NAC (N-acetyl-L-cysteine) : CK(318) : AC(76)

Diseases : Alcohol Toxicity : CK(337) : AC(125)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Enzyme Inhibitors : CK(473) : AC(251), Hepatoprotective : CK(2523) : AC(1099), Prostaglandin PGE2 downregulation : CK(96) : AC(46)

Dietary tetrahydrocurcumin reduces renal fibrosis and cardiac hypertrophy.

Pubmed Data : Pharmacol Res Perspect. 2018 04 ;6(2):e00385. Epub 2018 Feb 19. PMID: 29468071

Article Published Date : Dec 31, 2017

Authors : Wei Ling Lau, Mahyar Khazaeli, Javad Savoj, Kasim Manekia, Maria Bangash, Roshni G Thakurta, Anhthu Dang, Nosratola D Vaziri, Bhupinder Singh

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Tetrahydrocurcumin : CK(80) : AC(39)

Diseases : Cardiac Hypertrophy : CK(52) : AC(30), Fibrosis : CK(16) : AC(10)

Pharmacological Actions : Anti-Fibrotic : CK(46) : AC(29), Antioxidants : CK(8430) : AC(3132), Cardioprotective : CK(1596) : AC(409)

Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in male mice, indicating its protective value against chemical carcinogenesis and toxicity.

Pubmed Data : Pharmacol Toxicol. 2003 Jan;92(1):33-8. PMID: 12710595

Article Published Date : Jan 01, 2003

Authors : Mohammad Iqbal, Som Datta Sharma, Yasumasa Okazaki, Masayoshi Fujisawa, Shigeru Okada

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cancers: All : CK(14773) : AC(4596)

Pharmacological Actions : Anticarcinogenic Agents : CK(1099) : AC(519), Antioxidants : CK(8430) : AC(3132), Phase II Detoxification Enzyme Inducer : CK(78) : AC(40)

The activation of EpRE/ARE system was up to four fold higher than the sum of the activities of the single ingredients.

Pubmed Data : Arch Biochem Biophys. 2015 Apr 15 ;572:28-35. Epub 2015 Feb 21. PMID: 25711533

Article Published Date : Apr 14, 2015

Authors : Karin Linnewiel-Hermoni, Marina Khanin, Michael Danilenko, Gabriel Zango, Yaara Amosi, Joseph Levy, Yoav Sharoni

Study Type : In Vitro Study

Additional Links

Substances : Carnosic Acid : CK(39) : AC(27), Carotenoids : CK(1796) : AC(356), Curcumin : CK(4417) : AC(2300), Flavonoids : CK(1215) : AC(379), Lycopene : CK(494) : AC(108), Polyphenols : CK(1109) : AC(390)

Diseases : Cancers: All : CK(14773) : AC(4596), Prostate Cancer : CK(1586) : AC(463)

Pharmacological Actions : Antineoplastic Agents : CK(1158) : AC(639), Antioxidants : CK(8430) : AC(3132), Antiproliferative : CK(2546) : AC(1685)

Additional Keywords : Natural Substance Synergy : CK(540) : AC(249)

"Curcumin nanoparticles improve the physicochemical properties of curcumin and effectively enhance its antioxidant and antihepatoma activities."

Pubmed Data : J Agric Food Chem. 2010 Jun 23 ;58(12):7376-82. PMID: 20486686

Article Published Date : Jun 23, 2010

Authors : Feng-Lin Yen, Tzu-Hui Wu, Cheng-Wei Tzeng, Liang-Tzung Lin, Chun-Ching Lin

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Hepatoma : CK(37) : AC(32), Liver Cancer : CK(1235) : AC(462)

Pharmacological Actions : Antineoplastic Agents : CK(1158) : AC(639), Antioxidants : CK(8430) : AC(3132)

Additional Keywords : Nanoencapsulated Curcumin : CK(3) : AC(2)

A novel curcumin derivative regenerates pancreatic islets in experimental type-1 diabetes in rats (long term study).

Pubmed Data : Diabetol Metab Syndr. 2013 ;5(1):75. Epub 2013 Nov 26. PMID: 24279645

Article Published Date : Dec 31, 2012

Authors : Mohamed T Abdel Aziz, Mohamed F El-Asmar, Ameen M Rezq, Soheir M Mahfouz, Mohamed A Wassef, Hanan H Fouad, Hanan H Ahmed, Fatma M Taha

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Diabetes Mellitus: Type 1 : CK(1130) : AC(301), Diabetes Mellitus: Type 1: Prevention : CK(255) : AC(50)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Regenerative : CK(52) : AC(28)

Additional Keywords : Beta Cell Regeneration : CK(78) : AC(29)

A review of the beneficial effects of antioxidants on Helicobacter pylori eradication.

Pubmed Data : Helicobacter. 2018 Dec ;23(6):e12535. Epub 2018 Sep 6. PMID: 30191635

Article Published Date : Nov 30, 2018

Authors : Yao-Bin Yang-Ou, Yi Hu, Yin Zhu, Nong-Hua Lu

Study Type : Meta Analysis, Review

Additional Links

Substances : Cranberry : CK(349) : AC(69), Curcumin : CK(4417) : AC(2300), NAC (N-acetyl-L-cysteine) : CK(318) : AC(76)

Diseases : Helicobacter Pylori Infection : CK(506) : AC(104)

Pharmacological Actions : Anti-Bacterial Agents : CK(1367) : AC(475), Antioxidants : CK(8430) : AC(3132)

Additional Keywords : Natural Substance/Drug Synergy : CK(352) : AC(142)

Antioxidants have the potential to be clinically applied to prevent cardiac toxicity and hand foot syndrome.

Pubmed Data : Integr Cancer Ther. 2014 Dec 25. Epub 2014 Dec 25. PMID: 25542609

Article Published Date : Dec 24, 2014

Authors : Ming-Thau Sheu, Hua-Jing Jhan, Chien-Ming Hsieh, Chien-Ju Wang, Hsiu-O Ho

Study Type : In Vitro Study

Additional Links

Substances : Antrodia cinnamomea : CK(2) : AC(2), Curcumin : CK(4417) : AC(2300), Resveratrol : CK(1511) : AC(865)

Diseases : Breast Cancer : CK(3592) : AC(1064), Chemotherapy-Induced Toxicity: Doxorubicin : CK(132) : AC(56)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Reactive Oxygen Species (ROS) attenuation : CK(1) : AC(1), Superoxide Dismutase Up-regulation : CK(530) : AC(174)

Additional Keywords : Natural Substance/Drug Synergy : CK(352) : AC(142)

Beta-carotene, curcumin, and ascorbic acid prevent hydrocortisone-induced genotoxicity.

Pubmed Data : Int J Radiat Oncol Biol Phys. 2002 Jan 1;52(1):212-23. PMID: 15586444

Article Published Date : Jan 01, 2002

Authors : Md Sultan Ahmad, Sheeba, Mohd Afzal

Study Type : In Vitro Study

Additional Links

Substances : beta-Carotene : CK(330) : AC(55), Curcumin : CK(4417) : AC(2300), Vitamin C : CK(2484) : AC(569)

Diseases : Corticosteroid-Induced Toxicity : CK(77) : AC(16), DNA damage : CK(1017) : AC(387)

Pharmacological Actions : DNA damage : CK(1017) : AC(387), Antioxidants : CK(8430) : AC(3132), Cell cycle arrest : CK(810) : AC(612), Genoprotective : CK(270) : AC(97)

Additional Keywords : Drug: Hydrocortisone : CK(1) : AC(1)

C urcumin protects against gamma-radiation induced DNA damage and lipid peroxidation in cultured human lymphocytes.

Pubmed Data : Mutat Res. 2006 Dec 10;611(1-2):96-103. Epub 2006 Sep 14. PMID: 16973408

Article Published Date : Dec 10, 2006

Authors : M Srinivasan, N Rajendra Prasad, Venugopal P Menon

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : DNA damage : CK(1017) : AC(387), Radiation Induced Illness: Immune Suppression : CK(3) : AC(3)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Radioprotective : CK(858) : AC(293)

Co-administration of antioxidant significantly increased plasma level of curcumin in animal models.

Pubmed Data : Mol Nutr Food Res. 2015 Nov 26. Epub 2015 Nov 26. PMID: 26608515

Article Published Date : Nov 25, 2015

Authors : Yoshiki Nimiya, Weicang Wang, Zheyuan Du, Elvira Sukamtoh, Julia Zhu, Eric Decker, Guodong Zhang

Study Type : Animal Study

Additional Links

Substances : Caffeic Acid : CK(43) : AC(25), Curcumin : CK(4417) : AC(2300), Gallic Acid : CK(58) : AC(33), Rosmarinic acid : CK(47) : AC(26), Vitamin C : CK(2484) : AC(569)

Diseases : Colon Cancer : CK(749) : AC(430)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Antiproliferative : CK(2546) : AC(1685)

Additional Keywords : Increased Bioavailability : CK(42) : AC(17), Metabolites : CK(64) : AC(20)

Curcumin alleviated HLS-induced reduction of bone mineral density in tibiae and preserved bone structure in tibiae and mechanical strength in femurs.

Pubmed Data : Osteoporos Int. 2015 May 12. Epub 2015 May 12. PMID: 25963235

Article Published Date : May 11, 2015

Authors : M Xin, Y Yang, D Zhang, J Wang, S Chen, D Zhou

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Osteoporosis : CK(1302) : AC(257)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Vitamin D Receptor (VDR) Modulator : CK(1) : AC(1)

Additional Keywords : Microgravity Induced Bone Loss : CK(2) : AC(1)

Curcumin ameliorates aflatoin-induced toxicity in serum of mice.

Pubmed Data : Acta Pol Pharm. 2008 May-Jun;65(3):339-43. PMID: 18646553

Article Published Date : May 01, 2008

Authors : Neeta Mathuria, Ramtej Jayram Verma

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Aflatoxicosis : CK(143) : AC(45)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin ameliorates aflatoxin-induced toxicity in DNA, RNA and protein in liver and kidney of mice.

Pubmed Data : Acta Pol Pharm. 2007 Nov-Dec;64(6):497-502. PMID: 18323242

Article Published Date : Nov 01, 2007

Authors : Neeta Mathuria, Ramtej Jayram Verma

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Aflatoxicosis : CK(143) : AC(45)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099), Renoprotective : CK(572) : AC(254)

Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Curcumin ameliorates aflatoxin-induced toxicity.

Pubmed Data : Poult Sci. 2008 Jun;87(6):1125-30. PMID: 18493001

Article Published Date : Jun 01, 2008

Authors : N K S Gowda, D R Ledoux, G E Rottinghaus, A J Bermudez, Y C Chen

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Aflatoxicosis : CK(143) : AC(45)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin and a curcumin copper complex has a radioprotective effect in mouse livers.

Pubmed Data : J Radiat Res (Tokyo). 2007 May;48(3):241-5. Epub 2007 Apr 27. PMID: 17464095

Article Published Date : May 01, 2007

Authors : Prabhakar R Koiram, Veeresh P Veerapur, Amit Kunwar, Beena Mishra, Atanu Barik, Indira K Priyadarsini, Unnikrishnan K Mazhuvancherry

Study Type : Animal Study

Additional Links

Substances : Copper : CK(84) : AC(18), Curcumin : CK(4417) : AC(2300)

Diseases : Radiation Induced Illness : CK(1048) : AC(265), Radiation Induced Illness: Liver : CK(2) : AC(1)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099), Radioprotective : CK(858) : AC(293)

Curcumin and eugenol prevents lipid peroxidation of rat liver microsomes.

Pubmed Data : Mol Cell Biochem. 1992 Apr;111(1-2):117-24. PMID: 1588934

Article Published Date : Apr 01, 1992

Authors : A C Reddy, B R Lokesh

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Eugenol : CK(27) : AC(17)

Diseases : Lipid Peroxidation : CK(695) : AC(255)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099)

Curcumin and naringenin exhibit neuroprotective properties in an animal model of Parkinson's disease.

Pubmed Data : Free Radic Res. 2005 Oct;39(10):1119-25. PMID: 16298737

Article Published Date : Oct 01, 2005

Authors : Virginia Zbarsky, Krishna P Datla, Shabnam Parkar, Deepal K Rai, Okezie I Aruoma, David T Dexter

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Naringenin : CK(90) : AC(54)

Diseases : Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin and taurine significantly minimized BPA-induced cardiotoxicity in rats.

Pubmed Data : Environ Sci Pollut Res Int. 2019 Mar 6. Epub 2019 Mar 6. PMID: 30840252

Article Published Date : Mar 05, 2019

Authors : Fatma Gökçe Apaydin, Ayşe Aslanturk, Meltem Uzunhisarcikli, Hatice Bas, Suna Kalender, Yusuf Kalender

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Taurine : CK(214) : AC(56)

Diseases : Bisphenol Toxicity : CK(373) : AC(96)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Cardioprotective : CK(1596) : AC(409)

Problem Substances : Bisphenol A : CK(685) : AC(178)

Curcumin and turmeric extract might be recommendable to recover liver activity.

Pubmed Data : Sci Rep. 2017 Jul 26 ;7(1):6513. Epub 2017 Jul 26. PMID: 28747775

Article Published Date : Jul 25, 2017

Authors : Hwa-Young Lee, Seung-Wook Kim, Geum-Hwa Lee, Min-Kyung Choi, Han-Wool Chung, Yong-Chul Lee, Hyung-Ryong Kim, Ho Jeong Kwon, Han-Jung Chae

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Turmeric : CK(5583) : AC(2569)

Diseases : Chemically-Induced Liver Damage : CK(634) : AC(255)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099)

Curcumin and turmeric inhibit experimental tumorigenesis and DNA adduct formation.

Pubmed Data : Nutr Cancer. 1998;30(2):163-6. PMID: 9589436

Article Published Date : Jan 01, 1998

Authors : K Krishnaswamy, V K Goud, B Sesikeran, M A Mukundan, T P Krishna

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Turmeric : CK(5583) : AC(2569)

Diseases : DNA damage : CK(1017) : AC(387), Oral Cancer : CK(223) : AC(86)

Pharmacological Actions : Antineoplastic Agents : CK(1158) : AC(639), Antioxidants : CK(8430) : AC(3132), Chemopreventive : CK(2835) : AC(787)

Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Curcumin at 30 and 60 mg/kg dose levels significantly attenuated vincristine induced neuropathy.

Pubmed Data : Pharm Biol. 2015 Jun ;53(6):838-48. Epub 2014 Nov 28. PMID: 25429779

Article Published Date : May 31, 2015

Authors : Anand Babu, K G Prasanth, Bhaskar Balaji

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chemotherapy-Induced Toxicity: Vincristine : CK(6) : AC(3)

Pharmacological Actions : Antinoceceptive : CK(193) : AC(51), Antioxidants : CK(8430) : AC(3132), Chemoprotective Agents : CK(356) : AC(146)

Curcumin attenuates high-fat-diet induced blood lipid elevation and oxidation.

Pubmed Data : Wei Sheng Yan Jiu. 2000 Jul;29(4):240-2. PMID: 12520931

Article Published Date : Jul 01, 2000

Authors : S Wang, B Chen, C Sun

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Hyperlipidemia : CK(670) : AC(155), Lipid Peroxidation : CK(695) : AC(255)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin combined with metformin may act synergistically on dyslipidemia and oxidative stress, as well as increased PON 1 levels.

Pubmed Data : Diabetol Metab Syndr. 2019 ;11:33. Epub 2019 Apr 30. PMID: 31061679

Article Published Date : Dec 31, 2018

Authors : Daniela Fernandes Roxo, Carlos Alberto Arcaro, Vania Ortega Gutierres, Mariana Campos Costa, Juliana Oriel Oliveira, Tayra Ferreira Oliveira Lima, Renata Pires Assis, Iguatemy Lourenço Brunetti, Amanda Martins Baviera

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Dyslipidemias : CK(391) : AC(75), Hyperglycemia : CK(539) : AC(130)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hypoglycemic Agents : CK(1446) : AC(342)

Additional Keywords : Natural Substance/Drug Synergy : CK(352) : AC(142)

Curcumin compensated the adverse effects of sodium arsenite on kidney tissue, lipid peroxidation and total antioxidant capacity of serum.

Pubmed Data : Exp Toxicol Pathol. 2016 Nov 28. Epub 2016 Nov 28. PMID: 27908582

Article Published Date : Nov 27, 2016

Authors : Hamid Reza Momeni, Najmeh Eskandari

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Arsenic Poisoning : CK(160) : AC(49)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Renoprotective : CK(572) : AC(254)

Problem Substances : Arsenite : CK(9) : AC(6)

Curcumin could ameliorate aluminium induced testicular damage.

Pubmed Data : Int J Fertil Steril. 2017 Oct ;11(3):166-175. Epub 2017 Aug 27. PMID: 28868838

Article Published Date : Sep 30, 2017

Authors : Ebrahim Cheraghi, Alireza Golkar, Kambiz Roshanaei, Behrang Alani

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Aluminum Toxicity : CK(207) : AC(75), Testicular Injury: Chemical/Metal Induced : CK(8) : AC(4)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Cytoprotective : CK(190) : AC(94)

Problem Substances : Aluminum : CK(274) : AC(78)

Curcumin could be useful to protect the liver from nicotine toxicity.

Pubmed Data : J Tradit Complement Med. 2016 Apr ;6(2):176-83. Epub 2015 Jan 31. PMID: 27114942

Article Published Date : Mar 31, 2016

Authors : Mohammadreza Salahshoor, Sabah Mohamadian, Seyran Kakabaraei, Shiva Roshankhah, Cyrus Jalili

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Nicotine/Tobacco Toxicity : CK(118) : AC(40)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099)

Curcumin could inhibit the pro-oxidant effects of gallic acid.

Pubmed Data : Ren Fail. 2015 Dec 27:1-9. Epub 2015 Dec 27. PMID: 26707166

Article Published Date : Dec 26, 2015

Authors : Sunny O Abarikwu, Mojisola Durojaiye, Adenike Alabi, Bede Asonye, Oghenetega Akiri

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Gallic Acid : CK(58) : AC(33)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin could protect against endosulfan induced immunotoxicity in human human peripheral blood mononuclear cells by attenuating apoptosis.

Pubmed Data : Hum Exp Toxicol. 2015 Aug 4. Epub 2015 Aug 4. PMID: 26242398

Article Published Date : Aug 03, 2015

Authors : Tanzeel Ahmed, B D Banerjee

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Pesticide Toxicity : CK(192) : AC(61)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Antioxidants : CK(8430) : AC(3132), Heat Shock Protein Inducer : CK(83) : AC(30)

Curcumin exerts a stroke preventive effect by attenuating oxidative stress to improve vascular endothelial function.

Pubmed Data : BMC Cardiovasc Disord. 2018 Mar 1 ;18(1):43. Epub 2018 Mar 1. PMID: 29490624

Article Published Date : Feb 28, 2018

Authors : Cong Lan, Xinjian Chen, Yuxun Zhang, Wei Wang, Wei Eric Wang, Yukai Liu, Yue Cai, Hongmei Ren, Shuo Zheng, Lin Zhou, Chunyu Zeng

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Stroke : CK(1365) : AC(168), Stroke: Attenuation/Recovery : CK(347) : AC(75)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin exerts an anti-hyperlipidemic effect against nicotine-induced lung toxicity and may be a promising agent for treatment of hyperlipidemia and atherosclerosis.

Pubmed Data : J Med Food. 2005;8(2):246-50. PMID: 16117619

Article Published Date : Jan 01, 2005

Authors : C Kalpana, K N Rajasekharan, Venugopal P Menon

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Atherosclerosis : CK(601) : AC(150), Hyperlipidemia : CK(670) : AC(155), Tobacco Toxicity : CK(111) : AC(19)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Cardioprotective : CK(1596) : AC(409)

Curcumin exhibits anti-cancer, anti-inflammatory and antioxidant activities.

Pubmed Data : Phytomedicine. 2000 Jul;7(4):303-8. PMID: 10969724

Article Published Date : Jul 01, 2000

Authors : R S Ramsewak, D L DeWitt, M G Nair

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Breast Cancer : CK(3592) : AC(1064), Colon Cancer : CK(749) : AC(430), Kidney Cancer : CK(148) : AC(42), Melanoma : CK(285) : AC(149)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Cyclooxygenase 1 Inhibitor : CK(34) : AC(27), Cyclooxygenase 2 Inhibitors : CK(464) : AC(272), Cyclooxygenase Inhibitors : CK(71) : AC(39)

Curcumin exhibits anti-cataract activity in the diabetic rat lens.

Pubmed Data : Mol Vis. 2005;11:561-8. Epub 2005 Jul 26. PMID: 16088325

Article Published Date : Jan 01, 2005

Authors : P Anil Kumar, P Suryanarayana, P Yadagiri Reddy, G Bhanuprakash Reddy

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cataract : CK(196) : AC(61), Diabetes: Cataract : CK(22) : AC(14)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin exhibits anti-HIV activity.

Pubmed Data : Res Virol. 1998 Jan-Feb;149(1):43-52. PMID: 9561563

Article Published Date : Jan 01, 1998

Authors : S Barthelemy, L Vergnes, M Moynier, D Guyot, S Labidalle, E Bahraoui

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : HIV Infections : CK(680) : AC(219)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin exhibits cytoprotective properties against shiga toxin.

Pubmed Data : Biochem Biophys Res Commun. 2001 Apr 27;283(1):36-41. PMID: 11322764

Article Published Date : Apr 27, 2001

Authors : A Sood, R Mathew, H Trachtman

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Shigellosis : CK(14) : AC(5)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Apoptotic : CK(2958) : AC(2075), Enzyme Inhibitors : CK(473) : AC(251), Heat Shock Protein Inducer : CK(83) : AC(30)

Curcumin exhibits hepatoprotective properties against selenium toxicity.

Pubmed Data : Indian J Physiol Pharmacol. 2005 Jan;49(1):111-4. PMID: 15881869

Article Published Date : Jan 01, 2005

Authors : S Padmaja, T N Raju

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Selenium : CK(937) : AC(167)

Diseases : Selenium Toxicity (Selenosis) : CK(2) : AC(1)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Enzyme Inhibitors : CK(473) : AC(251), Hepatoprotective : CK(2523) : AC(1099)

Curcumin has a cytoprotective effect against paracetomol-induced cytotoxicity.

Pubmed Data : Biochem Pharmacol. 1990 Jun 15;39(12):1869-75. PMID: 2353930

Article Published Date : Jun 15, 1990

Authors : I A Donatus, Sardjoko, N P Vermeulen

Study Type : In Vitro Study

Additional Links

Substances : Catechols : CK(14) : AC(11), Curcumin : CK(4417) : AC(2300)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(166) : AC(61), Lipid Peroxidation : CK(695) : AC(255), NSAID-induced toxicity : CK(314) : AC(95)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Cytoprotective : CK(190) : AC(94)

Curcumin has a detoxifiying and antioxidant effect in rats experimentallly exposed to mercury.

Pubmed Data : Cont Lens Anterior Eye. 2009 Dec 21. Epub 2009 Dec 21. PMID: 20229497

Article Published Date : Dec 21, 2009

Authors : Rakhi Agarwal, Sudhir K Goel, Jai Raj Behari

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Mercury Poisoning : CK(228) : AC(178)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Detoxifier : CK(408) : AC(131)

Curcumin has a protective effect on myocardial ischemia reperfusion injury.

Pubmed Data : Zhong Yao Cai. 2005 Oct;28(10):920-2. PMID: 16479932

Article Published Date : Oct 01, 2005

Authors : Hong Cheng, Weiguan Liu, Xiaomei Ai

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Lipid Peroxidation : CK(695) : AC(255), Myocardial Ischemia : CK(137) : AC(61)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Cardioprotective : CK(1596) : AC(409)

Curcumin has an ameliorative effect on chlorpyrifos-induced biochemical changes in Cyprinus carpio.

Pubmed Data : Ecotoxicol Environ Saf. 2018 Apr 30 ;151:49-54. Epub 2018 Jan 3. PMID: 29306070

Article Published Date : Apr 29, 2018

Authors : M Enis Yonar

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Pesticide Toxicity : CK(192) : AC(61)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Problem Substances : Chlorpyrifos : CK(12) : AC(2)

Curcumin has ant-allergic activities.

Pubmed Data : Biol Pharm Bull. 2005 Aug;28(8):1438-43. PMID: 16079489

Article Published Date : Aug 01, 2005

Authors : Makoto Suzuki, Tomonori Nakamura, Sachi Iyoki, Akihiro Fujiwara, Yuhya Watanabe, Kunihiko Mohri, Kimiaki Isobe, Kageyoshi Ono, Shingo Yano

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Allergies : CK(703) : AC(132)

Pharmacological Actions : Anti-Allergic Agents : CK(167) : AC(61), Antioxidants : CK(8430) : AC(3132)

Curcumin has anti-leukemia properties.

Pubmed Data : J Nat Prod. 2007 Dec;70(12):1884-8. Epub 2007 Dec 13. PMID: 18076140

Article Published Date : Dec 01, 2007

Authors : Miguel López-Lázaro, Elaine Willmore, Andrew Jobson, Kathryn L Gilroy, Hannah Curtis, Kay Padget, Caroline A Austin

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Leukemia : CK(1005) : AC(398)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin has been shown to be very effective against cataract.

Pubmed Data : Pharmacol Rep. 2016 Jan 22 ;68(3):561-569. Epub 2016 Jan 22. PMID: 26894964

Article Published Date : Jan 21, 2016

Authors : Thiagarajan Raman, Manikandan Ramar, Munusamy Arumugam, Seyed Mohammad Nabavi, Mosur Kumaraswamy Nagarajan Sai Varsha

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cataract : CK(196) : AC(61)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Cytoprotective : CK(190) : AC(94)

Curcumin has leishmanicidal activity.

Pubmed Data : Biol Pharm Bull. 2002 Jan;25(1):131-3. PMID: 11824543

Article Published Date : Jan 01, 2002

Authors : Tatsuo Koide, Mitsuhiko Nose, Yuiko Ogihara, Yoshisada Yabu, Nobuo Ohta

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Leishmaniasis : CK(53) : AC(36)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Leishmanicidal : CK(38) : AC(24)

Curcumin has preventive effects on oxidative stress parameters against ischemia-reperfusion injury.

Pubmed Data : Eur Rev Med Pharmacol Sci. 2015 Dec ;19(23):4664-70. PMID: 26698266

Article Published Date : Nov 30, 2015

Authors : Y Yılmaz, K Taken, M Atar, M Ergün, H Söylemez

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Ischemia : CK(76) : AC(38)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin has protective effects against hepatic ischemia/reperfusion injury. Its mechanism might be related to the overexpression of heat shock protein 70 and antioxidant enzymes.

Pubmed Data : World J Gastroenterol. 2007 Apr 7;13(13):1953-61. PMID: 17461496

Article Published Date : Apr 07, 2007

Authors : Shi-Qiang Shen, Yuan Zhang, Jin-Jian Xiang, Cheng-Long Xiong

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Liver Disease : CK(145) : AC(41)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Apoptotic : CK(2958) : AC(2075), Enzyme Inhibitors : CK(473) : AC(251), Heat Shock Protein Inducer : CK(83) : AC(30)

Additional Keywords : Heat Shock Protein Inducer : CK(5) : AC(4)

Curcumin has radioprotective properties.

Pubmed Data : Biophys Chem. 2001 Aug 30;92(1-2):119-26. PMID: 11527584

Article Published Date : Aug 30, 2001

Authors : S Kapoor, K I Priyadarsini

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Radiation Induced Illness : CK(1048) : AC(265)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Radioprotective : CK(858) : AC(293)

Curcumin improved total antioxidant capacity and lowered PSA scores.

Pubmed Data : Nutr Cancer. 2016 ;68(1):77-85. Epub 2016 Jan 15. PMID: 26771294

Article Published Date : Dec 31, 2015

Authors : Jalal Hejazi, Reza Rastmanesh, Forough-Azam Taleban, Seyed-Hadi Molana, Ehsan Hejazi, Golamreza Ehtejab, Noboru Hara

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Prostate Cancer : CK(1586) : AC(463)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin improves the metabolic status in diabetic conditions.

Pubmed Data : Phytother Res. 2007 Apr;21(4):395-7. PMID: 8609907

Article Published Date : Apr 01, 2007

Authors : P S Babu, K Srinivasan

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Blood Sugar Problems : CK(6570) : AC(1119), Lipid Peroxidation : CK(695) : AC(255)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species.

Pubmed Data : Cancer Lett.2006 Jul 28;239(1):144-50. Epub 2005 Nov 21 PMID: 16770527

Article Published Date : Jul 28, 2006

Authors : Manikandan Panchatcharam, Sumitra Miriyala, Vinaya Subramani Gayathri, Lonchin Suguna

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Wound Healing : CK(539) : AC(161)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin induces programmed cell death in human promyelocytic leukemia HL-60 cells.

Pubmed Data : Life Sci. 2008 Feb 13;82(7-8):367-75. Epub 2007 Dec 7. PMID: 18187158

Article Published Date : Feb 13, 2008

Authors : Ya-Fan Liao, Hui-Chih Hung, Tzyh-Chyuan Hour, Pei-Chen Hsu, Ming-Ching Kao, Gregory J Tsay, Guang-Yaw Liu

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Leukemia: Acute promyelocytic leukemia : CK(13) : AC(11)

Pharmacological Actions : Anticarcinogenic Agents : CK(1099) : AC(519), Antioxidants : CK(8430) : AC(3132), Apoptotic : CK(2958) : AC(2075)

Curcumin inhibits human leukemia cells.

Pubmed Data : Biochim Biophys Acta. 1996 Nov 15;1317(2):95-100. PMID: 8950193

Article Published Date : Nov 15, 1996

Authors : M L Kuo, T S Huang, J K Lin

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Promyelocytic leukemia : CK(98) : AC(83)

Pharmacological Actions : Antineoplastic Agents : CK(1158) : AC(639), Antioxidants : CK(8430) : AC(3132), Apoptotic : CK(2958) : AC(2075), Bcl-2 protein down-regulation : CK(198) : AC(131), Oncogene Suppressor : CK(15) : AC(11)

Curcumin inhibits radiation-impaired healing of excisional wounds in mice.

Pubmed Data : J Wound Care. 2004 Mar;13(3):107-9. PMID: 15045805

Article Published Date : Mar 01, 2004

Authors : G C Jagetia, G K Rajanikant

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Radiation Induced Illness : CK(1048) : AC(265), Wound Healing : CK(539) : AC(161)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Radioprotective : CK(858) : AC(293)

Curcumin inhibits xanthine oxidase.

Pubmed Data : Nutrition. 2006 Jun;22(6):593-9. PMID: 19800788

Article Published Date : Jun 01, 2006

Authors : Liang Shen, Hong-Fang Ji

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Gout : CK(135) : AC(32)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Enzyme Inhibitors : CK(473) : AC(251), Xanthine oxidase inhibitor : CK(26) : AC(13)

Curcumin intervention ameliorates the AFB(1) induced toxicity.

Pubmed Data : J Ethnopharmacol. 2010 Feb 17;127(3):641-4. Epub 2009 Dec 14. PMID: 20015472

Article Published Date : Feb 17, 2010

Authors : Sujatha Nayak, R B Sashidhar

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Aflatoxicosis : CK(143) : AC(45), Chemically-Induced Liver Damage : CK(634) : AC(255), Liver Damage: Aflatoxin-Induced : CK(35) : AC(15)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Curcumin is a potential glucose-lowering agent and antioxidant in type 2 diabetic mice.

Pubmed Data : Phytother Res. 2008 Feb;22(2):180-4. PMID: 18398869

Article Published Date : Feb 01, 2008

Authors : Kwon-Il Seo, Myung-Sook Choi, Un Ju Jung, Hye-Jin Kim, Jiyoung Yeo, Seon-Min Jeon, Mi-Kyung Lee

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Insulin Resistance : CK(1683) : AC(346)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hypoglycemic Agents : CK(1446) : AC(342)

Curcumin is capable of modulating the expression of over 2,000 genes in a cancer cell line simultaneously.

Pubmed Data : Nutr Cancer. 2012 ;64(4):607-16. Epub 2012 Apr 10. PMID: 22489823

Article Published Date : Dec 31, 2011

Authors : Seethalakshmi Sreenivasan, Karthiyaini Thirumalai, Subramanian Krishnakumar

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Turmeric : CK(5583) : AC(2569)

Diseases : Retinoblastoma : CK(43) : AC(12)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075), Cell cycle arrest : CK(810) : AC(612)

Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Curcumin may attenuate diabetic complications.

Pubmed Data : FEBS Lett. 2009 Nov 19;583(22):3637-42. Epub 2009 Oct 20. PMID: 19850041

Article Published Date : Nov 19, 2009

Authors : P Muthenna, P Suryanarayana, Shravan K Gunda, J Mark Petrash, G Bhanuprakash Reddy

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Diabetic Complications : CK(1563) : AC(333)

Pharmacological Actions : Aldose reductase inhibitor : CK(15) : AC(4), Antioxidants : CK(8430) : AC(3132)

Curcumin may be beneficial in the treatment of acute stress induced anxiety and enhancement of memory function.

Pubmed Data : Brain Res Bull. 2015 Jun ;115:1-8. Epub 2015 Apr 11. PMID: 25869755

Article Published Date : May 31, 2015

Authors : Saida Haider, Fizza Naqvi, Zehra Batool, Saiqa Tabassum, Sadia Sadir, Laraib Liaquat, Faizan Naqvi, Nudrat Anwer Zuberi, Hina Shakeel, Tahira Perveen

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Anxiety Disorders : CK(1225) : AC(180), Brain Inflammation : CK(274) : AC(145), Stress : CK(623) : AC(103)

Pharmacological Actions : Anti-Anxiety Agents : CK(356) : AC(59), Antioxidants : CK(8430) : AC(3132), Malondialdehyde Down-regulation : CK(554) : AC(152), Superoxide Dismutase Up-regulation : CK(530) : AC(174)

Curcumin may have a role to play in modulating pathological scar formation.

Pubmed Data : J Cell Mol Med. 2009 Apr;13(4):712-25. Epub 2008 Apr 10. PMID: 18410527

Article Published Date : Apr 01, 2009

Authors : A Scharstuhl, H A M Mutsaers, S W C Pennings, W A Szarek, F G M Russel, F A D T G Wagener

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Scars : CK(32) : AC(11), Wound Healing : CK(539) : AC(161)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Apoptotic : CK(2958) : AC(2075)

Curcumin may have therapeutic value in Alzheimer disease prevention.

Pubmed Data : Cancer Lett. 2009 Nov 24. Epub 2009 Nov 24. PMID: 11755008

Article Published Date : Nov 24, 2009

Authors : S A Frautschy, W Hu, P Kim, S A Miller, T Chu, M E Harris-White, G M Cole

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin may have therapeutic value in the treatment of endometriosis.

Pubmed Data : Indian J Biochem Biophys. 2009 Feb;46(1):59-65. PMID: 19374255

Article Published Date : Feb 01, 2009

Authors : Snehasikta Swarnakar, Sumit Paul

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Endometriosis : CK(164) : AC(35)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin may offer potential remedy of gastric antral ulcerations.

Pubmed Data : J Microbiol Biotechnol. 2016 May 20. Epub 2016 May 20. PMID: 27197667

Article Published Date : May 19, 2016

Authors : Jeong-Hwan Kim, Soojung Jin, Hyun Ju Kwon, Byung Woo Kim

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Gastric Ulcer : CK(289) : AC(117), Lipid Peroxidation : CK(695) : AC(255)

Pharmacological Actions : Anti-Ulcer Agents : CK(213) : AC(84), Antioxidants : CK(8430) : AC(3132), Gastroprotective : CK(155) : AC(73)

Problem Substances : Naproxen : CK(54) : AC(7)

Curcumin may play a protective role against oxidative stress in islet transplantation outcomes.

Pubmed Data : Pancreas. 2009 May;38(4):454-60. PMID: 19188863

Article Published Date : May 01, 2009

Authors : A N Balamurugan, Leonid Akhov, Gopalan Selvaraj, Subbiah Pugazhenthi

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Organ Transplantation: Pancreatic Islet Cells : CK(8) : AC(5)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Apoptotic : CK(2958) : AC(2075)

Curcumin may potentially serve as an antioxidant therapy of Pelizaeus-Merzbacher disease caused by PLP1 gene duplication.

Pubmed Data : Ann Clin Transl Neurol. 2015 Aug ;2(8):787-96. Epub 2015 Jun 24. PMID: 26339673

Article Published Date : Jul 31, 2015

Authors : Dirk B Epplen, Thomas Prukop, Tobias Nientiedt, Philipp Albrecht, Friederike A Arlt, Ruth M Stassart, Celia M Kassmann, Axel Methner, Klaus-Armin Nave, Hauke B Werner, Michael W Sereda

Study Type : Transgenic Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Leukodystrophy : CK(4) : AC(2), Pelizaeus-Merzbacher disease (PMD) : CK(2) : AC(1)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin might increase the effect of vitamin C in protecting the function of endothelial cells through its anti-oxidant with hypoglycemic and hypolipidemic actions.

Pubmed Data : Clin Hemorheol Microcirc. 2006;35(4):481-9. PMID: 17148847

Article Published Date : Jan 01, 2006

Authors : Suthiluk Patumraj, Natchaya Wongeakin, Patarin Sridulyakul, Amporn Jariyapongskul, Narisa Futrakul, Srichitra Bunnag

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Vitamin C : CK(2484) : AC(569)

Diseases : Dyslipidemias : CK(391) : AC(75), Endothelial Dysfunction : CK(1210) : AC(237)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hypoglycemic Agents : CK(1446) : AC(342), Hypolipidemic : CK(1288) : AC(265)

Additional Keywords : Natural Substance Synergy : CK(540) : AC(249)

Curcumin pre-treatment could reduce the effect of radiation on the skin of patients receiving radiotherapy for the treatment of cancer.

Pubmed Data : Antioxidants (Basel). 2015 ;4(1):25-41. Epub 2015 Jan 13. PMID: 26785336

Article Published Date : Dec 31, 2014

Authors : Ganesh Chandra Jagetia, Golgod Krishnamurthy Rajanikant

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Radiotherapy : CK(60) : AC(15)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Radioprotective : CK(858) : AC(293), Superoxide Dismutase Up-regulation : CK(530) : AC(174)

Curcumin pretreatment has a beneficial effect on wound healing in mice whole-body exposed to various doses of gamma-radiation.

Pubmed Data : Chemosphere. 2009 Mar;74(9):1145-51. Epub 2009 Jan 13. PMID: 15172199

Article Published Date : Mar 01, 2009

Authors : Ganesh Chandra Jagetia, G K Rajanikant

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Radiation Induced Illness : CK(1048) : AC(265), Wound Healing : CK(539) : AC(161)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Radioprotective : CK(858) : AC(293)

Curcumin prevents acrylamide-induced DNA damage in liver cells.

Pubmed Data : Wei Sheng Yan Jiu. 2009 Jul;38(4):392-5. PMID: 19689063

Article Published Date : Jul 01, 2009

Authors : Jun Cao, Liping Jiang, Chengyan Geng, Xiaofeng Yao

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Acrylamide-induced toxicity : CK(16) : AC(9), DNA damage : CK(1017) : AC(387)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099)

Curcumin prevents cholesterol oxidation, indicating its therapeutic value in attenuating atherosclerosis and lesion formation.

Pubmed Data : Prostaglandins Other Lipid Mediat. 2009 Nov;90(1-2):13-20. Epub 2009 Jun 21. PMID: 19549571

Article Published Date : Nov 01, 2009

Authors : Mohamedain M Mahfouz, Sherry Q Zhou, Fred A Kummerow

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Atherosclerosis : CK(601) : AC(150), Cholesterol: Oxidation : CK(518) : AC(117)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin prevents cisplatin-induced chromosomal abberations in rat bone marrow cells.

Pubmed Data : Mutat Res. 2000 Feb 16;465(1-2):131-7. PMID: 10708978

Article Published Date : Feb 16, 2000

Authors : L M Antunes, M C Araújo, J D Darin, M L Bianchi

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chemotherapy Induced Myelotoxicity : CK(48) : AC(13), Chemotherapy-Induced Toxicity: Cisplatin : CK(319) : AC(133)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Genoprotective : CK(270) : AC(97)

Curcumin prevents cisplatin-induced decrease in the tight and adherens junctions: relation to oxidative stress.

Pubmed Data : Food Funct. 2015 Oct 15. Epub 2015 Oct 15. PMID: 26467482

Article Published Date : Oct 14, 2015

Authors : Joyce Trujillo, Eduardo Molina-Jijón, Omar Noel Medina-Campos, Rafael Rodríguez-Muñoz, José Luis Reyes, María L Loredo, Diana Barrera-Oviedo, Enrique Pinzón, Daniela Saraí Rodríguez-Rangel, José Pedraza-Chaverri

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(319) : AC(133)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Chemoprotective Agents : CK(356) : AC(146), Renoprotective : CK(572) : AC(254)

Curcumin prevents DNA damage associated with benzo[a]pyrene exposure.

Pubmed Data : Mutat Res. 2004 Feb 14;557(2):203-13. PMID: 14729375

Article Published Date : Feb 14, 2004

Authors : K Polasa, A N Naidu, I Ravindranath, K Krishnaswamy

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Benzo[a]pyrene-induced Toxicity : CK(65) : AC(36), DNA damage : CK(1017) : AC(387)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Genoprotective : CK(270) : AC(97)

Curcumin prevents myocardial ischemia in the cat heart.

Pubmed Data : Indian J Med Res. 1995 Jan;101:31-5. PMID: 7883281

Article Published Date : Jan 01, 1995

Authors : M Dikshit, L Rastogi, R Shukla, R C Srimal

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Myocardial Ischemia : CK(137) : AC(61)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Cardioprotective : CK(1596) : AC(409)

Additional Keywords : Natural Substances Versus Drugs : CK(1698) : AC(302)

Curcumin prevents radiation-induced mammary tumors.

Pubmed Data : Int J Radiat Oncol Biol Phys. 2002 Jan 1;52(1):212-23. PMID: 11777641

Article Published Date : Jan 01, 2002

Authors : Hiroshi Inano, Makoto Onoda

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Breast Cancer : CK(3592) : AC(1064), Breast Cancer: Prevention : CK(552) : AC(82)

Pharmacological Actions : Anticarcinogenic Agents : CK(1099) : AC(519), Antineoplastic Agents : CK(1158) : AC(639), Antioxidants : CK(8430) : AC(3132), Enzyme Inhibitors : CK(473) : AC(251), Radioprotective : CK(858) : AC(293)

Curcumin prevents radiation-induced thymic lymphoma in mice.

Pubmed Data : J Environ Pathol Toxicol Oncol. 2007;26(4):273-9. PMID: 18197825

Article Published Date : Jan 01, 2007

Authors : P Dange, H Sarma, Badri Narain Pandey, Kaushala Prasad Mishra

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Vitamin C : CK(2484) : AC(569)

Diseases : Aging : CK(1658) : AC(438), Lymphoma : CK(253) : AC(83), Radiation Induced Illness : CK(1048) : AC(265)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Chemopreventive : CK(2835) : AC(787)

Curcumin protects against chemically-induced liver damage in rats.

Pubmed Data : Life Sci. 2006 Apr 4;78(19):2188-93. Epub 2005 Nov 8. PMID: 16288784

Article Published Date : Apr 04, 2006

Authors : Tomomi Sugiyama, Jun-ichi Nagata, Azumi Yamagishi, Kaori Endoh, Morio Saito, Kazuhiko Yamada, Shizuo Yamada, Keizo Umegaki

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chemically-Induced Liver Damage : CK(634) : AC(255)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099)

Curcumin protects against colchicine-induced cognitive dysfunction and oxidative stress in rats.

Pubmed Data : Hum Exp Toxicol. 2012 Jan 19. Epub 2012 Jan 19. PMID: 22262262

Article Published Date : Jan 19, 2012

Authors : S Khurana, S Jain, P K Mediratta, B D Banerjee, K K Sharma

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cognitive dysfunction: colchicine-induced : CK(2) : AC(1)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects against cypermethrin-induced oxidative stress in rats.

Pubmed Data : Exp Toxicol Pathol. 2010 Dec 2. Epub 2010 Dec 2. PMID: 21130633

Article Published Date : Dec 02, 2010

Authors : Palanisamy Sankar, Avinash G Telang, Ayyasamy Manimaran

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Pesticide Toxicity : CK(192) : AC(61), Pesticide Toxicity: Cypermethrin : CK(4) : AC(2)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin protects against doxorubicin (adriamycin)-induced toxicity in rats.

Pubmed Data : J Med Food. 2009 Apr;12(2):394-402. PMID: 19459743

Article Published Date : Apr 01, 2009

Authors : Ragaa Hosny Mohamad, Amal Mohamad El-Bastawesy, Zekry Khalid Zekry, Hussain A Al-Mehdar, Mohamad Gamil Abdel Monaam Al-Said, Soaad Shaker Aly, Sabry Mohamed Sharawy, Mahmuod M El-Merzabani

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chemically-Induced Liver Damage : CK(634) : AC(255), Chemotherapy-Induced Toxicity: Doxorubicin : CK(132) : AC(56)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Additional Keywords : Drug: Doxorubicin : CK(168) : AC(64), Drug Side Effect Attenuation : CK(251) : AC(49), Plant Extracts : CK(7645) : AC(2539)

Curcumin protects against gamma radiation-induced ileal mucosal damage.

Pubmed Data : Arch Toxicol. 2009 Jun;83(6):609-17. Epub 2008 Aug 27. PMID: 18754102

Article Published Date : Jun 01, 2009

Authors : Meryem Akpolat, Mehmet Kanter, Mustafa Cem Uzal

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Radiation Induced Illness : CK(1048) : AC(265), Radiation Induced Illness: Mucositis : CK(164) : AC(21)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Radioprotective : CK(858) : AC(293)

Curcumin protects against gamma ray induced conformational change of human serum albumin.

Pubmed Data : Int J Biol Macromol. 2017 Jun ;99:600-607. Epub 2017 Mar 6. PMID: 28274864

Article Published Date : May 31, 2017

Authors : Turban Kar, Pijush Basak, Rittik Kumar Ghosh, Maitree Bhattacharyya

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Radiation Induced Illness : CK(1048) : AC(265)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Radioprotective : CK(858) : AC(293)

Additional Keywords : Antioxidants : CK(1) : AC(1), CURCUMIN : CK(2) : AC(1), CURCUMIN : CK(2) : AC(1), CURCUMIN : CK(2) : AC(1)

Curcumin protects against ischaemia/reperfusion insult in rat forebrain.

Pubmed Data : Pharmacol Res. 2002 Sep;46(3):273-9. PMID: 12220971

Article Published Date : Sep 01, 2002

Authors : Asser I Ghoneim, Ashraf B Abdel-Naim, Amani E Khalifa, Ezzeddin S El-Denshary

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Ischemia : CK(136) : AC(52)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects against ischemia/reperfusion injury in rat kidneys.

Pubmed Data : World J Urol. 2008 Jun;26(3):285-91. Epub 2008 Mar 29. PMID: 18373094

Article Published Date : Jun 01, 2008

Authors : Omer Bayrak, Ebru Uz, Reyhan Bayrak, Faruk Turgut, Ali Fuat Atmaca, Semsettin Sahin, Mehmet Erol Yildirim, Arif Kaya, Ersin Cimentepe, Ali Akcay

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Kidney Damage : CK(193) : AC(64)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Enzyme Inhibitors : CK(473) : AC(251), Renoprotective : CK(572) : AC(254)

Curcumin protects against isoproterenol induced myocardial infarction in rats.

Pubmed Data : Nutr Cancer. 2001;39(1):148-53. PMID: 8858558

Article Published Date : Jan 01, 2001

Authors : C Nirmala, R Puvanakrishnan

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Myocardial Infarction : CK(1101) : AC(162)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Cardioprotective : CK(1596) : AC(409)

Curcumin protects against lipid peroxidation and oxidative stress during nicotine-induced toxicity.

Pubmed Data : Toxicol Mech Methods. 2004;14(6):339-43. PMID: 20021100

Article Published Date : Jan 01, 2004

Authors : C Kalpana, Venugopal P Menon

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Lipid Peroxidation : CK(695) : AC(255), Nicotine/Tobacco Toxicity : CK(118) : AC(40)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin protects against oxidative and nitrative stress after praziquantel treatment in liver fluke-infected hamsters.

Pubmed Data : Int J Parasitol. 2011 Jan 21. Epub 2011 Jan 21. PMID: 21256849

Article Published Date : Jan 21, 2011

Authors : Lakhanawan Charoensuk, Porntip Pinlaor, Suksanti Prakobwong, Yusuke Hiraku, Umawadee Laothong, Wipaporn Ruangjirachuporn, Puangrat Yongvanit, Somchai Pinlaor

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Drug-Induced Toxicity : CK(562) : AC(83), Parasitic Diseases : CK(65) : AC(29)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099)

Curcumin protects against smoke-induced DNA damage.

Pubmed Data : Metabolism. 2002 Jul;51(7):887-92. PMID: 1937145

Article Published Date : Jul 01, 2002

Authors : L Srinivas, V K Shalini

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : DNA damage : CK(1017) : AC(387)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin protects rat myocardium against isoproterenol-induced ischemic injury.

Pubmed Data : J Cardiovasc Pharmacol. 2010 Apr;55(4):377-84. PMID: 20125031

Article Published Date : Apr 01, 2010

Authors : Vineeta Tanwar, Jaspreet Sachdeva, Mahaveer Golechha, Santosh Kumari, Dharamvir Singh Arya

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Myocardial Ischemia : CK(137) : AC(61)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Cardioprotective : CK(1596) : AC(409)

Curcumin protects testicle cells of mice from damage induced by chronic alcohol administration.

Pubmed Data : Med Sci Monit. 2008 Nov;14(11):BR237-42. PMID: 18971866

Article Published Date : Nov 01, 2008

Authors : Francesco Giannessi, Maria Anita Giambelluca, Lucia Grasso, Maria Concetta Scavuzzo, Riccardo Ruffoli

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alcohol Toxicity : CK(337) : AC(125), Infertility: Male : CK(387) : AC(95), Testicular Diseases : CK(46) : AC(19), Testosterone: Too Low : CK(435) : AC(79)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin reduces burn progression in rats.

Pubmed Data : Acad Emerg Med. 2007 Dec;14(12):1125-9. PMID: 18045885

Article Published Date : Dec 01, 2007

Authors : Adam J Singer, Steve A McClain, Alexander Romanov, Jean Rooney, Tom Zimmerman

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Burns : CK(79) : AC(30)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin reduces high glucose induced neural tube defects by blocking cellular stress and caspase activation.

Pubmed Data : Am J Obstet Gynecol. 2015 Jun ;212(6):802.e1-8. Epub 2015 Jan 13. PMID: 25595578

Article Published Date : May 31, 2015

Authors : Yanqing Wu, Fang Wang, E Albert Reece, Peixin Yang

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Diabetes: Oxidative Stress : CK(131) : AC(40), Diabetic Complications : CK(1563) : AC(333), Neural Tube Defects : CK(16) : AC(4)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Antioxidants : CK(8430) : AC(3132)

Curcumin reduces oxidative stress associated with exposure to an environmental pollutant.

Pubmed Data : Toxicol Ind Health. 2011 Jan 18. Epub 2011 Jan 18. PMID: 21245202

Article Published Date : Jan 18, 2011

Authors : Osman Ciftci, Ilknur Ozdemir, Sadettin Tanyildizi, Sedat Yildiz, Hakan Oguzturk

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Dioxin Toxicity : CK(25) : AC(10)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin supplementation could ameliorate cognitive deficits and reverse biochemical alterations in a ICV-streptozotocin Alzheimer's rat model.

Pubmed Data : Eur J Pharmacol. 2016 Jan 5 ;770:52-60. Epub 2015 Dec 2. PMID: 26638997

Article Published Date : Jan 04, 2016

Authors : Doaa M Samy, Cherine A Ismail, Rasha A Nassra, Teshreen M Zeitoun, Azhar M Nomair

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Brain: Oxidative Stress : CK(79) : AC(46), Diabetes Mellitus: Type 2 : CK(3572) : AC(624)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin supplementation could improve diabetes-induced endothelial dysfunction.

Pubmed Data : BMC Complement Altern Med. 2010;10:57. Epub 2010 Oct 14. PMID: 20946622

Article Published Date : Jan 01, 2010

Authors : Sirada Rungseesantivanon, Naris Thenchaisri, Preecha Ruangvejvorachai, Suthiluk Patumraj

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Diabetes: Cardiovascular Illness : CK(700) : AC(107), Endothelial Dysfunction : CK(1210) : AC(237)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Curcumin treatment has a protective effect against intestinal damage induced by bile duct ligation.

Pubmed Data : J Invest Surg. 2015 Dec 18:1-9. Epub 2015 Dec 18. PMID: 26682581

Article Published Date : Dec 17, 2015

Authors : Mehmet Kanter, Mumtaz Takir, Hasan Huseyin Mutlu, Betul Kanter, Osman Kostek, Aybala Erek Toprak

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cholestasis : CK(125) : AC(36)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Antioxidants : CK(8430) : AC(3132), Gastroprotective : CK(155) : AC(73)

Curcumin was able to significantly ameliorate ROT induced dopaminergic neuronal oxidative damage in the SNpc of rats.

Pubmed Data : Mol Med Rep. 2015 Dec 8. Epub 2015 Dec 8. PMID: 26648392

Article Published Date : Dec 07, 2015

Authors : Qunli Cui, Xin Li, Hongcan Zhu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain: Oxidative Stress : CK(79) : AC(46), Neurodegenerative Diseases : CK(3582) : AC(932), Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin works synergistically with antifungal drugs.

Pubmed Data : FEMS Yeast Res. 2010 Aug 1;10(5):570-8. Epub 2010 Apr 23. PMID: 20528949

Article Published Date : Aug 01, 2010

Authors : Monika Sharma, Raman Manoharlal, Arvind Singh Negi, Rajendra Prasad

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Flavonoids : CK(1215) : AC(379), Polyphenols : CK(1109) : AC(390), Vitamin C : CK(2484) : AC(569)

Diseases : Candida Infection : CK(241) : AC(112)

Pharmacological Actions : Antifungal Agents : CK(234) : AC(146), Antioxidants : CK(8430) : AC(3132), Apoptotic : CK(2958) : AC(2075)

Additional Keywords : Drug Synergy : CK(352) : AC(157)

Curcumin works synergistically with erythropoietin to stimulate liver regeneration.

Pubmed Data : Langenbecks Arch Surg. 2008 May;393(3):325-32. Epub 2008 Feb 27. PMID: 18301913

Article Published Date : May 01, 2008

Authors : Daniel Seehofer, Ulf P Neumann, Anja Schirmeier, Jessica Carter, Si-Young Ria Cho, Andri Lederer, Nada Rayes, Michael D Menger, Andreas K Nüssler, Peter Neuhaus

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Liver Disease : CK(145) : AC(41)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Antiproliferative : CK(2546) : AC(1685)

Additional Keywords : Drug Synergy : CK(352) : AC(157), Liver Regeneration : CK(16) : AC(7)

Curcumin works synergistically with insulin on muscle cell glucose metabolism.

Pubmed Data : Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2366-73. Epub 2010 Jun 1. PMID: 20561944

Article Published Date : Aug 01, 2010

Authors : Changkeun Kang, Euikyung Kim

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Diabetes Insipidus : CK(35) : AC(5), Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Insulin Resistance : CK(1683) : AC(346)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hypoglycemic Agents : CK(1446) : AC(342)

Additional Keywords : Drug Synergy : CK(352) : AC(157)

Curcumin's neuroprotective properties may be due to its anticholinesterase, antioxidant activity and brain insulin receptor modulating activities.

Pubmed Data : Pharmacol Res. 2010 Mar;61(3):247-52. Epub 2009 Dec 21. PMID: 20026275

Article Published Date : Mar 01, 2010

Authors : Rahul Agrawal, Bhanvi Mishra, Ethika Tyagi, Chandishwar Nath, Rakesh Shukla

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Dementia : CK(571) : AC(79), Memory Disorders : CK(344) : AC(104)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Cholinesterase Inhibitors : CK(10) : AC(8), Insulin Receptor Modulator : CK(12) : AC(2)

Curcumin, an antioxidant and anti-inflammatory agent protects endothelial cells against oxidative stress.

Pubmed Data : Biol Pharm Bull. 2006 Apr;29(4):670-4. PMID: 10889462

Article Published Date : Apr 01, 2006

Authors : R Motterlini, R Foresti, R Bassi, C J Green

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Endothelial Dysfunction : CK(1210) : AC(237), Hypoxia : CK(123) : AC(60)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Curcumin, capsaicin, and garlic have a beneficial effect in the red blood cells and liver of cholesterol fed rats.

Pubmed Data : Acta Pharmacol Sin. 2007 Oct;28(10):1559-65. PMID: 15296079

Article Published Date : Oct 01, 2007

Authors : R K Kempaiah, K Srinivasan

Study Type : Animal Study

Additional Links

Substances : Capsaicin : CK(141) : AC(57), Curcumin : CK(4417) : AC(2300), Garlic : CK(824) : AC(274)

Diseases : High Cholesterol : CK(1774) : AC(271)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Cardioprotective : CK(1596) : AC(409), Hepatoprotective : CK(2523) : AC(1099)

Curcumin, resveratrol and EGCG may have a therapeutic role in proliferative vitreoretinopathy (PVR).

Pubmed Data : Curr Eye Res. 2010 Nov;35(11):1021-33. PMID: 20958191

Article Published Date : Nov 01, 2010

Authors : Anne F Alex, Manfred Spitznas, André P Tittel, Christian Kurts, Nicole Eter

Study Type : In Vitro Study

Additional Links

Substances : Catechin : CK(522) : AC(170), Curcumin : CK(4417) : AC(2300), Resveratrol : CK(1511) : AC(865)

Diseases : Eye Diseases: Vitreous Disorders : CK(12) : AC(3), Proliferative Vitreoretinopathy (PVR) : CK(1) : AC(1)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075)

Additional Keywords : Stilbenes : CK(402) : AC(242)

Curcumin, resveratrol and vanillin protects against DNA damage.

Pubmed Data : Minerva Med. 1988 May;79(5):387-90. PMID: 12561251

Article Published Date : May 01, 1988

Authors : Guo-An Liu, Rong-Liang Zheng

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Flavonoids : CK(1215) : AC(379), Polyphenols : CK(1109) : AC(390), Resveratrol : CK(1511) : AC(865), Vanillin : CK(2) : AC(2)

Diseases : DNA damage : CK(1017) : AC(387)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Genoprotective : CK(270) : AC(97)

Curcumin-free turmeric extract inhibits chemically-induced gastric tumors in mice.

Pubmed Data : Cancer Lett. 1997 Sep 16;118(1):79-85. PMID: 9310263

Article Published Date : Sep 16, 1997

Authors : S S Deshpande, A D Ingle, G B Maru

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Turmeric : CK(5583) : AC(2569)

Diseases : Benzo[a]pyrene-induced Toxicity : CK(65) : AC(36), Gastric Cancer : CK(622) : AC(198)

Pharmacological Actions : Anticarcinogenic Agents : CK(1099) : AC(519), Antioxidants : CK(8430) : AC(3132)

Additional Keywords : Plant Extracts : CK(7645) : AC(2539), Turmeric Versus Curcumin : CK(4) : AC(2)

Curcuminoids protect against neuronal cell death in an Alzheimer disease model.

Pubmed Data : Neurosci Lett. 2001 Apr 27;303(1):57-61. PMID: 11297823

Article Published Date : Apr 27, 2001

Authors : D S Kim, S Y Park, J K Kim

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Dietary constituents inhibit chemically-induced DNA and hemoglobin adductions associated with cancer.

Pubmed Data : Appl Radiat Isot. 2003 Mar;58(3):291-8. PMID: 12595006

Article Published Date : Mar 01, 2003

Authors : Hongli Li, Yan Cheng, Haifang Wang, Hongfang Sun, Yuanfang Liu, Kexin Liu, Shixiang Peng

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Garlic : CK(824) : AC(274), Grape Seed Extract : CK(346) : AC(101), Polyphenols : CK(1109) : AC(390), Tea : CK(2180) : AC(455), Vitamin C : CK(2484) : AC(569), Vitamin E : CK(1881) : AC(335)

Diseases : Chemical Exposure: Nitrobenzene : CK(2) : AC(1), DNA damage : CK(1017) : AC(387)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Chemopreventive : CK(2835) : AC(787)

Dietary curcumin and capsaicin have hypolipidemic and antioxidant effects.

Pubmed Data : Life Sci. 2001 Dec 7;70(3):253-67. PMID: 17960446

Article Published Date : Dec 07, 2001

Authors : H Manjunatha, K Srinivasan

Study Type : Animal Study

Additional Links

Substances : Capsaicin : CK(141) : AC(57), Curcumin : CK(4417) : AC(2300)

Diseases : High Cholesterol : CK(1774) : AC(271)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hypolipidemic : CK(1288) : AC(265)

Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice.

Pubmed Data : Radiat Res. 2010 May;173(5):590-601. PMID: 20426658

Article Published Date : May 01, 2010

Authors : James C Lee, Paul A Kinniry, Evguenia Arguiri, Matthew Serota, Stathis Kanterakis, Shampa Chatterjee, Charalambos C Solomides, Prashanthi Javvadi, Constantinos Koumenis, Keith A Cengel, Melpo Christofidou-Solomidou

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Lung Cancer : CK(1043) : AC(393), Pulmonary Fibrosis : CK(140) : AC(49), Radiation Induced Illness : CK(1048) : AC(265)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Radioprotective : CK(858) : AC(293)

Improvement of sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by curcumin: results of a randomised, double-blind, placebo-controlled trial.

Pubmed Data : Br J Nutr. 2012 Oct ;108(7):1272-9. Epub 2011 Nov 18. PMID: 22099425

Article Published Date : Sep 30, 2012

Authors : Yunes Panahi, Amirhossein Sahebkar, Mojtaba Amiri, Seyyed Masoud Davoudi, Fatemeh Beiraghdar, Seyyedeh Leila Hoseininejad, Marjan Kolivand

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chemical Weapon Agent Injury: Sulfur Mustard : CK(31) : AC(4), Pruritus : CK(35) : AC(6)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Problem Substances : Mustard Gas : CK(1) : AC(1)

Low dose Resveratrol and Curcumin enhances the Centchroman action through ROS mediated JNK/p38 as well as mitochondrial pathway in MCF-7 cells.

Pubmed Data : PLoS One. 2012 ;7(6):e37736. Epub 2012 Jun 29. PMID: 22768036

Article Published Date : Dec 31, 2011

Authors : Neetu Singh, Deeba Zaidi, Hari Shyam, Ramesh Sharma, Anil Kumar Balapure

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Polyphenols : CK(1109) : AC(390), Resveratrol : CK(1511) : AC(865)

Diseases : Breast Cancer : CK(3592) : AC(1064), Breast Cancer: Triple Negative : CK(262) : AC(144)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075), Cell cycle arrest : CK(810) : AC(612)

Additional Keywords : Natural Substance/Drug Synergy : CK(352) : AC(142)

Melatonin and curcumin protect against ndomethacin-induced acute gastric ulceration.

Pubmed Data : Free Radic Biol Med. 2006 Sep 15;41(6):911-25. Epub 2006 Apr 30. PMID: 16934674

Article Published Date : Sep 15, 2006

Authors : Krishnendu Ganguly, Parag Kundu, Aditi Banerjee, Russel J Reiter, Snehasikta Swarnakar

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Melatonin : CK(1194) : AC(394)

Diseases : Drug-Induced Toxicity: Indomethacin : CK(25) : AC(13), Gastric Ulcer : CK(289) : AC(117)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Gastroprotective : CK(155) : AC(73), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(287) : AC(147)

Additional Keywords : Drug: Indomethacin : CK(43) : AC(24)

Melatonin may increase cell survival in the hippocampus via decreasing oxidative stress and SIRT2 expression and increasing Bcl-2 expression.

Pubmed Data : Brain Res Bull. 2018 Jan 8 ;137:306-310. Epub 2018 Jan 8. PMID: 29325994

Article Published Date : Jan 07, 2018

Authors : Arzu Keskin-Aktan, Kazime Gonca Akbulut, Çiğdem Yazici-Mutlu, Gizem Sonugur, Müge Ocal, Hakan Akbulut

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Melatonin : CK(1194) : AC(394)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

NAC and curcumin ameliorate pesticide-induced oxidative DNA damage in human peripheral blood mononuclear cells.

Pubmed Data : Environ Monit Assess. 2010 Nov 4. Epub 2010 Nov 4. PMID: 21049288

Article Published Date : Nov 04, 2010

Authors : Tanzeel Ahmed, Rahul Pathak, Md Mustafa, Rajarshi Kar, Ashok K Tripathi, Rafat S Ahmed, B D Banerjee

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), NAC (N-acetyl-L-cysteine) : CK(318) : AC(76)

Diseases : DNA damage : CK(1017) : AC(387), Pesticide Toxicity : CK(192) : AC(61)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Naringenin-induced enhanced antioxidant defence system meliorates cholinergic neurotransmission and consolidates memory in male rats.

Pubmed Data : Life Sci. 2017 Dec 26. Epub 2017 Dec 26. PMID: 29287782

Article Published Date : Dec 25, 2017

Authors : Laraib Liaquat, Zehra Batool, Sadia Sadir, Sahar Rafiq, SidrahShahzad, Tahira Perveen, Saida Haider

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Naringenin : CK(90) : AC(54), Quercetin : CK(716) : AC(335)

Diseases : Neurodegenerative Diseases : CK(3582) : AC(932)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Antioxidants : CK(1) : AC(1), CURCUMIN : CK(2) : AC(1), CURCUMIN : CK(2) : AC(1), CURCUMIN : CK(2) : AC(1), CURCUMIN : CK(2) : AC(1), CURCUMIN : CK(2) : AC(1)

Obtained findings suggest that curcumin may attenuate the MSG-induced apoptosis.

Pubmed Data : Gen Physiol Biophys. 2018 May ;37(3):329-336. PMID: 29938678

Article Published Date : Apr 30, 2018

Authors : Miodrag Vucic, Irena Cojbasic, Jelena Vucic, Voja Pavlovic

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Antioxidants : CK(8430) : AC(3132)

Problem Substances : Monosodium Glutamate (MSG) : CK(108) : AC(36)

Oral administration of curcumin could effectively stabilize artesunate-induced testicular dysfunction.

Pubmed Data : Dose Response. 2015 Apr-Jun;13(2):1559325815592393. Epub 2015 Jun 26. PMID: 26673878

Article Published Date : Mar 31, 2015

Authors : Ketaki R Desai, Dhrupadsinh K Rajput, Pragnesh B Patel, Hyacinth N Highland

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Anti-Malarial Drug Toxicity : CK(4) : AC(2)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Superoxide Dismutase Up-regulation : CK(530) : AC(174)

Oral curcumin positively modulates blood lipid levels and lipid peroxidation.

Pubmed Data : Indian J Physiol Pharmacol. 1992 Oct;36(4):273-5. PMID: 1291482

Article Published Date : Oct 01, 1992

Authors : K B Soni, R Kuttan

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cholesterol: High : CK(1226) : AC(195), HDL: Low : CK(305) : AC(50), Lipid Peroxidation : CK(695) : AC(255)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hypolipidemic : CK(1288) : AC(265)

Pectic polysaccharides of Momordica charantia in combination with curcumin had liver protective effects.

Pubmed Data : Biochem Biophys Rep. 2017 Sep ;11:64-71. Epub 2017 Jun 23. PMID: 28955769

Article Published Date : Aug 31, 2017

Authors : Hasina Perveen, Moumita Dash, Shamima Khatun, Moulima Maity, Syed Sirajul Islam, Sandip Chattopadhyay

Study Type : In Vitro Study

Additional Links

Substances : Bitter Melon : CK(95) : AC(44), Curcumin : CK(4417) : AC(2300)

Diseases : Arsenic Poisoning : CK(160) : AC(49)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Cytoprotective : CK(190) : AC(94)

Additional Keywords : Polysaccharides : CK(5) : AC(3)

Problem Substances : Arsenic : CK(152) : AC(30)

Polyphenol antioxidants have properties to treat neurodegenerative diseases.

Pubmed Data : Basic Clin Neurosci. 2016 Apr ;7(2):81-90. PMID: 27303602

Article Published Date : Mar 31, 2016

Authors : Amin Ataie, Mohammad Shadifar, Ramin Ataee

Study Type : Review

Additional Links

Substances : Allicin : CK(48) : AC(25), Carnosic Acid : CK(39) : AC(27), Curcumin : CK(4417) : AC(2300), EGCG (Epigallocatechin gallate) : CK(721) : AC(380), Isothiocyanate : CK(15) : AC(4), Quercetin : CK(716) : AC(335), Resveratrol : CK(1511) : AC(865), Rosmarinic acid : CK(47) : AC(26), Sulforaphane : CK(624) : AC(303)

Diseases : Neurodegenerative Diseases : CK(3582) : AC(932)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Prophylactic use of curcumin may effectively rescue pancreatic islets from damage without affecting the normal function of these cellular structures.

Pubmed Data : BJU Int. 2002 Jun;89(9):829-34. PMID: 17900558

Article Published Date : Jun 01, 2002

Authors : Kanitkar Meghana, Galande Sanjeev, Bhonde Ramesh

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Diabetes Mellitus: Type 1 : CK(1130) : AC(301)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Additional Keywords : Beta Cell Protection : CK(61) : AC(25)

Quercetin, curcumin, ginseng and rutin exhibit anti-cancer activity in an animal model of colon cancer.

Pubmed Data : Arch Neurol. 2003 Feb;60(2):194-200. PMID: 15831530

Article Published Date : Feb 01, 2003

Authors : Suresh R Volate, Destiny M Davenport, Stephanie J Muga, Michael J Wargovich

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Ginseng : CK(840) : AC(233), Quercetin : CK(716) : AC(335), Rutin : CK(180) : AC(75)

Diseases : Colon Cancer : CK(749) : AC(430), Colon Polyps : CK(49) : AC(16), Gastrointestinal polyps : CK(23) : AC(4)

Pharmacological Actions : Anticarcinogenic Agents : CK(1099) : AC(519), Antioxidants : CK(8430) : AC(3132), Chemopreventive : CK(2835) : AC(787)

Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Review: Curcumin may have therapeutic value in obesity.

Pubmed Data : Pediatr Rehabil. 2004 Oct-Dec;7(4):245-60. PMID: 21091916

Article Published Date : Oct 01, 2004

Authors : Lini Alappat, Atif B Awad

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Obesity : CK(2443) : AC(521)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Rosemary/carnosic acid, alone or combined with curcumin, may be useful to prevent and treat ER-negative breast cancer.

Pubmed Data : Fitoterapia. 2012 Oct ;83(7):1160-8. Epub 2012 Jul 22. PMID: 22828666

Article Published Date : Sep 30, 2012

Authors : Linda Saxe Einbond, Hsan-Au Wu, Ryota Kashiwazaki, Kan He, Marc Roller, Tao Su, Xiaomei Wang, Sarah Goldsberry

Study Type : In Vitro Study

Additional Links

Substances : Carnosic Acid : CK(39) : AC(27), Curcumin : CK(4417) : AC(2300), Rosemary : CK(237) : AC(91)

Diseases : Breast Cancer: Triple Negative : CK(262) : AC(144)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075), Cell cycle arrest : CK(810) : AC(612)

Additional Keywords : Gene Expression Regulation : CK(431) : AC(214), Natural Substance Synergy : CK(540) : AC(249), Plant Extracts : CK(7645) : AC(2539)

The application of curcumin may be a novel strategy to protect against age-related change in AMD.

Pubmed Data : Drug Des Devel Ther. 2015;9:5337-5344. Epub 2015 Sep 25. PMID: 26445530

Article Published Date : Dec 31, 2014

Authors : Wei Zhu, Yan Wu, Yi-Fang Meng, Jin-Yu Wang, Ming Xu, Jian-Jun Tao, Jiong Lu

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Macular Degeneration : CK(207) : AC(34)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Antioxidants : CK(8430) : AC(3132)

The combination of curcumin and quercetin appears to reduce the number and size of ileal and rectal adenomas in patients with Familialadenomatous polyposis without appreciable toxicity.

Pubmed Data : Clin Gastroenterol Hepatol. 2006 Aug;4(8):1035-8. Epub 2006 Jun 6. PMID: 16757216

Article Published Date : Aug 01, 2006

Authors : Marcia Cruz-Correa, Daniel A Shoskes, Patricia Sanchez, Rhongua Zhao, Linda M Hylind, Steven D Wexner, Francis M Giardiello

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Quercetin : CK(716) : AC(335)

Diseases : Colon Polyps : CK(49) : AC(16), Colorectal Cancer : CK(1646) : AC(619), Familial Adenomatous Polyposis : CK(14) : AC(3), Gastrointestinal polyps : CK(23) : AC(4)

Pharmacological Actions : Antineoplastic Agents : CK(1158) : AC(639), Antioxidants : CK(8430) : AC(3132)

The combination of hyaluronic acid, chondroitin sulfate, curcumin and quercetin was effective in preventing recurrent urinary tract infections.

Pubmed Data : Eur J Obstet Gynecol Reprod Biol. 2016 Dec ;207:125-128. Epub 2016 Nov 1. PMID: 27838537

Article Published Date : Nov 30, 2016

Authors : M Torella, F Del Deo, A Grimaldi, S A Iervolino, M Pezzella, C Tammaro, P Gallo, C Rappa, P De Franciscis, N Colacurci

Study Type : Human Study

Additional Links

Substances : Chondroitin Sulfate : CK(35) : AC(7), Curcumin : CK(4417) : AC(2300), Hyaluronic Acid : CK(105) : AC(13), Quercetin : CK(716) : AC(335)

Diseases : Aging : CK(1658) : AC(438), Urinary Tract Infections : CK(409) : AC(59)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)

Additional Keywords : Risk Reduction : CK(6417) : AC(686)

The influence of separate and combined supplementation with curcumin and quercetin on the protective capacity in rats.

Pubmed Data : Vopr Pitan. 2017 ;86(2):14-22. Epub 2017 Feb 27. PMID: 30645874

Article Published Date : Dec 31, 2016

Authors : A S Balakina, I V Aksenov, N V Trusov, G V Guseva, L I Avrenyeva, L V Kravchenko, V A Tutelyan

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Quercetin : CK(716) : AC(335)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Heme oxygenase-1 up-regulation : CK(73) : AC(40), Nrf2 activation : CK(177) : AC(86)

Additional Keywords : Natural Substance Synergy : CK(540) : AC(249)

The joint use of doxorubicin and curcumin resulted in a significant reduction of free radical oxidation.

Pubmed Data : Fiziol Zh. 2015 ;61(5):90-8. PMID: 26845849

Article Published Date : Dec 31, 2014

Authors : O Linnik, T Drevytska, O Gonchar, S Chornyi, A Kovalyov, I Mankovska

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(132) : AC(56)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Chemoprotective Agents : CK(356) : AC(146)

The protective effect of curcumin to PTU-induced hepatotoxicity is attributed to its antioxidative properties.

Pubmed Data : Food Chem Toxicol. 2018 Oct 24 ;123:169-180. Epub 2018 Oct 24. PMID: 30367912

Article Published Date : Oct 23, 2018

Authors : Suresh Kumar Bunker, Abinash Dutta, Jyotsnarani Pradhan, Jagneshwar Dandapat, G B N Chainy

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Graves Disease : CK(106) : AC(12), Hyperthyroidism : CK(223) : AC(38)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099)

Additional Keywords : Epigenetic Modification : CK(220) : AC(90)

The role of some natural Nrf2 activators and its effect in diabetes is discussed in this review.

Pubmed Data : Clin Chim Acta. 2015 Jul 9. Epub 2015 Jul 9. PMID: 26165427

Article Published Date : Jul 08, 2015

Authors : Angélica Saraí Jiménez-Osorio, Susana González-Reyes, José Pedraza-Chaverri

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Resveratrol : CK(1511) : AC(865), Sulforaphane : CK(624) : AC(303), Vitamin D : CK(5183) : AC(695)

Diseases : Diabetes Mellitus: Type 1: Prevention : CK(255) : AC(50), Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Hyperglycemia : CK(539) : AC(130), Prediabetes : CK(192) : AC(23)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Nrf2 activation : CK(177) : AC(86)

The study demonstrated the safety, tolerance, and enhanced efficacy of CGM in comparison with unformulated standard curcumin.

Pubmed Data : J Clin Psychopharmacol. 2016 Jun ;36(3):236-43. PMID: 27043120

Article Published Date : May 31, 2016

Authors : Subash Pandaran Sudheeran, Della Jacob, Johannah Natinga Mulakal, Gopakumar Gopinathan Nair, Abhilash Maliakel, Balu Maliakel, Ramadasan Kuttan, Krishnakumar Im

Study Type : Human Study

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Substances : Curcumin : CK(4417) : AC(2300), Curcuminoids : CK(4681) : AC(2355), Fenugreek : CK(267) : AC(66), Fiber : CK(898) : AC(117)

Diseases : Anxiety : CK(48) : AC(8), Stress : CK(623) : AC(103)

Pharmacological Actions : Anti-Anxiety Agents : CK(356) : AC(59), Antioxidants : CK(8430) : AC(3132)

Additional Keywords : Blood Brain Barrier : CK(34) : AC(13), Plant Extracts : CK(7645) : AC(2539)