Focused Research Topics Curcumin & Antioxidants

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Curcumin Curcumin: Lipidated

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563 Research Articles in Total

A review focusing on the anti-inflammatory and anti-oxidant properties of curcumin and discuss its therapeutic potential in bipolar disorders.

Pubmed Data : Med Hypotheses. 2013 May ;80(5):606-12. Epub 2013 Feb 26. PMID: 23484676
Article Published Date : Apr 30, 2013
Authors : Elisa Brietzke, Rodrigo B Mansur, Andre Zugman, André F Carvalho, Danielle S Macêdo, Danielle S Cha, Vanessa C Abílio, Roger S McIntyre
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Bipolar Disorder : CK(489) : AC(68), Brain Inflammation : CK(1784) : AC(928)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroplasticity enhancement : CK(158) : AC(54), Neuroprotective Agents : CK(20061) : AC(7949)
Additional Keywords : Cytokines : CK(35) : AC(12)

A review of curcumin's effects.

Pubmed Data : Crit Rev Food Sci Nutr. 2017 Sep 2 ;57(13):2889-2895. PMID: 26528921
Article Published Date : Sep 01, 2017
Authors : Betül Kocaadam, Nevin Şanlier
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

A review of effective medicinal plants in the treatment of the cyclic mastalgia.

Pubmed Data : J Pharmacopuncture. 2019 Sep ;22(3):131-139. Epub 2019 Sep 30. PMID: 31673442
Article Published Date : Aug 31, 2019
Authors : Azin Niazi, Vafa Baradaran Rahimi, Hooman Hatami, Reza Shirazinia, Reza Esmailzadeh-Dizaji, Nafiseh Askari, Vahid Reza Askari
Study Type : Review
Additional Links
Substances : Chaste Tree (Chasteberry) : CK(54) : AC(15), Curcumin : CK(7239) : AC(3319), Ginkgo biloba : CK(2047) : AC(658), Nigella sativa (aka Black Seed) : CK(1912) : AC(494), St. Johns Wort : CK(401) : AC(118), Sweet Orange : CK(48) : AC(17), Wheat Germ : CK(88) : AC(31)
Diseases : Mastalgia : CK(123) : AC(12)
Pharmacological Actions : Analgesics : CK(9680) : AC(1472), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

A review of the cancer chemoprevention by phytochemicals.

Pubmed Data : Molecules. 2017 Mar 3 ;22(3). Epub 2017 Mar 3. PMID: 28273819
Article Published Date : Mar 02, 2017
Authors : Haseeb Zubair, Shafquat Azim, Aamir Ahmad, Mohammad Aslam Khan, Girijesh Kumar Patel, Seema Singh, Ajay Pratap Singh
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), EGCG (Epigallocatechin gallate) : CK(1587) : AC(820), Honokiol : CK(435) : AC(271), Resveratrol : CK(3228) : AC(1513)
Diseases : Cancers: All : CK(36404) : AC(14363), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Chemoprotective Agents : CK(4278) : AC(1621)

A review of the use of curcumin in psoriasis.

Pubmed Data : Open Access Maced J Med Sci. 2018 Jan 25 ;6(1):218-220. Epub 2018 Jan 21. PMID: 29484027
Article Published Date : Jan 24, 2018
Authors : Veronica Di Nardo, Serena Gianfaldoni, Georgi Tchernev, Uwe Wollina, Victoria Barygina, Jacopo Lotti, Farah Daaboul, Torello Lotti
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Psoriasis : CK(922) : AC(255)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

A review of turmeric and its major compound curcumin on health.

Pubmed Data : Front Pharmacol. 2020 ;11:01021. Epub 2020 Sep 15. PMID: 33041781
Article Published Date : Dec 31, 2019
Authors : Javad Sharifi-Rad, Youssef El Rayess, Alain Abi Rizk, Carmen Sadaka, Raviella Zgheib, Wissam Zam, Simona Sestito, Simona Rapposelli, Katarzyna Neffe-Skocińska, Dorota Zielińska, Bahare Salehi, William N Setzer, Noura S Dosoky, Yasaman Taheri, Marc El Beyrouthy, Miquel Martorell, Elise Adrian Ostrander, Hafiz Ansar Rasul Suleria, William C Cho, Alfred Maroyi, Natália Martins
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963), Hepatoprotective : CK(8989) : AC(3831), Neuroprotective Agents : CK(20061) : AC(7949)

A review on curcumins wound healing properties provides evidence for enhanced granulation tissue formation, collagen deposition, tissue remodeling and wound contraction.

Pubmed Data : Life Sci. 2014 Oct 22 ;116(1):1-7. Epub 2014 Sep 6. PMID: 25200875
Article Published Date : Oct 21, 2014
Authors : Dania Akbik, Maliheh Ghadiri, Wojciech Chrzanowski, Ramin Rohanizadeh
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716), Wound Healing : CK(4555) : AC(1412)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Ameliorative effect of curcumin against lead acetate-induced hemato-biochemical alterations, hepatotoxicity, and testicular oxidative damage.

Pubmed Data : Environ Sci Pollut Res Int. 2020 Apr ;27(10):10950-10965. Epub 2020 Jan 17. PMID: 31953765
Article Published Date : Mar 31, 2020
Authors : Fatma M Abdelhamid, Hebatallah A Mahgoub, Ahmed I Ateya
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Testicular Injury: Chemical/Metal Induced : CK(774) : AC(385)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Immunomodulatory : CK(6531) : AC(2360)
Problem Substances : Lead : CK(700) : AC(231)

Anti-inflammatory, antioxidant, and immunomodulatory effects of curcumin in ovalbumin-sensitized rat.

Pubmed Data : Biofactors. 2017 Jul 8 ;43(4):567-576. Epub 2017 May 16. PMID: 28509396
Article Published Date : Jul 07, 2017
Authors : Farzaneh Shakeri, Mohammad Hossein Boskabady
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Immune Dysregulation: TH1/TH2 imbalance : CK(223) : AC(66)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Immunomodulatory : CK(6531) : AC(2360)

Anti-obesity effects of polyphenol intake: current status and future possibilities.

Pubmed Data : Int J Mol Sci. 2020 Aug 6 ;21(16). Epub 2020 Aug 6. PMID: 32781724
Article Published Date : Aug 05, 2020
Authors : Mariarosaria Boccellino, Stefania D'Angelo
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Polyphenols : CK(2736) : AC(1003), Quercetin : CK(1876) : AC(855), Resveratrol : CK(3228) : AC(1513)
Diseases : Obesity : CK(11004) : AC(2672)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Anti-Obesity Agents : CK(5172) : AC(1320)

Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies.

Pubmed Data : Nutrients. 2020 Jan 1 ;12(1). Epub 2020 Jan 1. PMID: 31906278
Article Published Date : Dec 31, 2019
Authors : Danja J Den Hartogh, Alessandra Gabriel, Evangelia Tsiani
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetes Mellitus: Type 2 : CK(12953) : AC(2579)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Hypoglycemic Agents : CK(9221) : AC(2076), Immunomodulatory : CK(6531) : AC(2360), Renoprotective : CK(4544) : AC(1971)

Antioxidants ameliorated Tetrachlorobenzoquinone induced ROS generation as well as the activation of NF-κB.

Pubmed Data : Environ Toxicol Pharmacol. 2015 Dec 21 ;41:241-250. Epub 2015 Dec 21. PMID: 26745386
Article Published Date : Dec 20, 2015
Authors : Juanli Fu, Qiong Shi, Xiufang Song, Xiaomin Xia, Chuanyang Su, Zixuan Liu, Erqun Song, Yang Song
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), NAC (N-acetyl-L-cysteine) : CK(1429) : AC(366), Vitamin E : CK(3040) : AC(571)
Diseases : Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), NF-kappaB Inhibitor : CK(5952) : AC(3464)
Problem Substances : Persistent organic pollutants (POPs) : CK(231) : AC(33)

Beneficial effects of curcumin in polycystic ovary syndrome.

Pubmed Data : Curr Med Chem. 2024 Oct 17. Epub 2024 Oct 17. PMID: 39421997
Article Published Date : Oct 16, 2024
Authors : Tayybeh Khamar, Najmeh Jahani, Amir Masoud Jafari-Nozad, Tahereh Farkhondeh, Saeed Samarghandian
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Polycystic Ovary Syndrome : CK(2116) : AC(332)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Benefits of curcumin in brain disorders.

Pubmed Data : Biofactors. 2019 Sep ;45(5):666-689. Epub 2019 Jun 11. PMID: 31185140
Article Published Date : Aug 31, 2019
Authors : Abid Bhat, Arehally M Mahalakshmi, Bipul Ray, Sunanda Tuladhar, Tousif A Hediyal, Esther Manthiannem, Jagadeeswari Padamati, Ramesh Chandra, Saravana B Chidambaram, Meena K Sakharkar
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alzheimer's Disease : CK(5355) : AC(2210), Amyotrophic Lateral Sclerosis : CK(803) : AC(216), Anxiety : CK(4246) : AC(759), Autism Spectrum Disorders : CK(3722) : AC(571), Dementia : CK(2211) : AC(386), Depression : CK(9574) : AC(1756), Depression : CK(9574) : AC(1756), Huntington Disease : CK(222) : AC(103), Multiple Sclerosis : CK(2432) : AC(557), Parkinson's Disease : CK(3012) : AC(1116), Stroke : CK(4410) : AC(773)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Both C. longa and curcumin improved paraquat-induced systemic and lung inflammation and oxidative stress.

Pubmed Data : Avicenna J Phytomed. 2022 Jul-Aug;12(4):414-424. PMID: 35782772
Article Published Date : Jun 30, 2022
Authors : Seyedeh Zahra Ghasemi, Arghavan Memarzia, Sepideh Behrouz, Zahra Gholamnezhad, Mohammad Hossein Boskabady
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Lung Damage : CK(441) : AC(192), Pesticide Toxicity : CK(1467) : AC(478)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)
Problem Substances : Paraquat : CK(190) : AC(94)

Both caloric restriction and dietary curcumin can improve obesity-associated comorbidities.

Pubmed Data : PLoS One. 2015 ;10(10):e0140431. Epub 2015 Oct 16. PMID: 26473740
Article Published Date : Dec 31, 2014
Authors : Marjana Rahman Sarker, Susan Franks, Nathalie Sumien, Nopporn Thangthaeng, Frank Filipetto, Michael Forster
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Obesity : CK(11004) : AC(2672)
Therapeutic Actions : Dietary Modification: Caloric Restriction : CK(46) : AC(11)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Cellular and molecular mechanisms of curcumin on thyroid gland disorders.

Pubmed Data : Curr Med Chem. 2022 Feb 10. Epub 2022 Feb 10. PMID: 35142266
Article Published Date : Feb 09, 2022
Authors : Farzaneh Shakeri, Bahram Bibak, Mohammad Reza Safdari, Zakieh Keshavarzi, Tannaz Jamialahmadi, Thozhukat Sathyapalan, Amirhossein Sahebkar
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Hypothyroidism : CK(863) : AC(152), Thyroid Diseases : CK(348) : AC(52)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Combined treatment of curcumin with low doses of prednisolone may find therapeutic use in arthritis.

Pubmed Data : J Pharm Pharmacol. 2014 Jan ;66(1):133-44. Epub 2013 Oct 21. PMID: 24138213
Article Published Date : Dec 31, 2013
Authors : Madhusudana Kuncha, Vegi Ganga Modi Naidu, Bidya Dhar Sahu, Shankar Ganesh Gadepalli, Ramakrishna Sistla
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Arthritis : CK(5826) : AC(1505)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)
Additional Keywords : Natural Substance/Drug Synergy : CK(1526) : AC(720), Plant Extracts : CK(18762) : AC(6782)

Comparation of anti-inflammatory and antioxidantactivities of curcumin, tetrahydrocurcuminand octahydrocurcuminin LPS-stimulated RAW264.7 macrophages.

Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:8856135. Epub 2020 Dec 22. PMID: 33424997
Article Published Date : Dec 31, 2019
Authors : Qing-Feng Xie, Juan-Juan Cheng, Jin-Fen Chen, Yu-Chao Feng, Guo-Shu Lin, Yang Xu
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Curcuminoids : CK(7851) : AC(3498), Tetrahydrocurcumin : CK(173) : AC(99)
Diseases : Inflammation : CK(16108) : AC(5498), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Nrf2 activation : CK(3156) : AC(1794)

Comparison of the protective effects of curcumin and caffeic acid phenethyl ester against doxorubicin-induced testicular toxicity.

Pubmed Data : Andrologia. 2020 Dec 1:e13919. Epub 2020 Dec 1. PMID: 33289171
Article Published Date : Nov 30, 2020
Authors : Zübeyir Huyut, Hamit Hakan Alp, Turan Yaman, Ömer Faruk Keleş, Zabit Yener, Fikret Türkan, Kemal Ayengin
Study Type : Animal Study
Additional Links
Substances : Caffeic acid phenethyl ester : CK(284) : AC(172), Curcumin : CK(7239) : AC(3319)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(845) : AC(423), Testicular Injury: Chemical/Metal Induced : CK(774) : AC(385)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Chemoprotective Agents : CK(4278) : AC(1621)

Curcumin administration can limit the poisonous impacts of deltamethrin.

Pubmed Data : J Biochem Mol Toxicol. 2019 Oct ;33(10):e22386. Epub 2019 Aug 27. PMID: 31454128
Article Published Date : Sep 30, 2019
Authors : Wenbin Shi, Daisong Zhang, Lei Wang, Nagaraja Sreeharsha, Yushan Ning
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Pyrethroid Insecticide Induced Toxicity : CK(24) : AC(12)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Heme oxygenase-1 up-regulation : CK(1336) : AC(776), Nrf2 activation : CK(3156) : AC(1794), Renoprotective : CK(4544) : AC(1971)
Problem Substances : Deltamethrin : CK(45) : AC(21)

Curcumin ameliorates doxorubicin-induced cardiotoxicity.

Pubmed Data : J Biochem Mol Toxicol. 2018 Feb ;32(2). Epub 2018 Jan 5. PMID: 29315967
Article Published Date : Jan 31, 2018
Authors : Fulya Benzer, Fatih Mehmet Kandemir, Mustafa Ozkaraca, Sefa Kucukler, Cuneyt Caglayan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(845) : AC(423)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Chemoprotective Agents : CK(4278) : AC(1621), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327)

Curcumin ameliorates hypertension via gut-brain communication in spontaneously hypertensive rat.

Pubmed Data : Toxicol Appl Pharmacol. 2021 Oct 15 ;429:115701. Epub 2021 Aug 25. PMID: 34453990
Article Published Date : Oct 14, 2021
Authors : Hong-Bao Li, Meng-Lu Xu, Meng-Meng Du, Xiao-Jing Yu, Juan Bai, Wen-Jie Xia, Zhi-Ming Dai, Chang-Xing Li, Ying Li, Qing Su, Xiao-Min Wang, Yuan-Yuan Dong, Yu-Ming Kang
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Brain Inflammation : CK(1784) : AC(928), Hypertension : CK(9125) : AC(1361)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Gut-brain Axis : CK(686) : AC(289)

Curcumin ameliorates lead-induced hepatotoxicity.

Pubmed Data : Biomolecules. 2019 Nov 5 ;9(11). Epub 2019 Nov 5. PMID: 31694300
Article Published Date : Nov 04, 2019
Authors : Ahlam Alhusaini, Laila Fadda, Iman H Hasan, Enas Zakaria, Abeer M Alenazi, Ayman M Mahmoud
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Inflammation : CK(16108) : AC(5498)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)
Problem Substances : Lead : CK(700) : AC(231)

Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production.

Pubmed Data : Clin Exp Pharmacol Physiol. 2018 Jan ;45(1):84-93. Epub 2017 Oct 3. PMID: 28853207
Article Published Date : Dec 31, 2017
Authors : Shuguang Han, Jing Xu, Xiangjun Guo, Mao Huang
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Influenza A : CK(582) : AC(204), Pneumonia : CK(1101) : AC(171)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Heme oxygenase-1 up-regulation : CK(1336) : AC(776), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin ameliorative effects against AP through induction of apoptosis and inhibition of micro-thrombosis, inflammation, and oxidative stress.

Pubmed Data : J Biochem Mol Toxicol. 2016 Feb 10. Epub 2016 Feb 10. PMID: 26862043
Article Published Date : Feb 09, 2016
Authors : Noha M Shafik, Ghada M Abou-Fard
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Pancreatitis : CK(500) : AC(186)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin and CoQ10 independently as well as in combination ameliorate chronic hyperalgesia in sickle mice.

Pubmed Data : Haematologica. 2015 Nov 6. Epub 2015 Nov 6. PMID: 26546503
Article Published Date : Nov 05, 2015
Authors : Yessenia Valverde, Barbara Benson, Mihir Gupta, Kalpna Gupta
Study Type : Transgenic Animal Study
Additional Links
Substances : Coenzyme Q10 : CK(2359) : AC(412), Curcumin : CK(7239) : AC(3319)
Diseases : Brain: Microglial Activation : CK(205) : AC(118), Hyperalgesia : CK(339) : AC(152), Sickle Cell Anemia : CK(244) : AC(31)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin and piperine in COVID-19: a promising duo to the rescue?

Pubmed Data : Adv Exp Med Biol. 2021 ;1327:197-204. PMID: 34279840
Article Published Date : Dec 31, 2020
Authors : Mahsa Miryan, Davood Soleimani, Gholamreza Askari, Tannaz Jamialahmadi, Paul C Guest, Mohammad Bagherniya, Amirhossein Sahebkar
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Piperine : CK(600) : AC(258)
Diseases : Coronavirus Infection : CK(3250) : AC(986)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Antiviral Agents : CK(3095) : AC(1702), Immunomodulatory : CK(6531) : AC(2360)

Curcumin and piperine showed strong antioxidant and protective effect against QA-induced behavioural and neurological alteration.

Pubmed Data : Pharmacology. 2016 Jan 30 ;97(3-4):151-160. Epub 2016 Jan 30. PMID: 26828892
Article Published Date : Jan 29, 2016
Authors : Shamsher Singh, Puneet Kumar
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Piperine : CK(600) : AC(258)
Diseases : Brain Inflammation : CK(1784) : AC(928)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)
Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

Curcumin and vitamin C attenuate gentamicin-induced nephrotoxicity.

Pubmed Data : Metabolites. 2022 Dec 28 ;13(1). Epub 2022 Dec 28. PMID: 36676974
Article Published Date : Dec 27, 2022
Authors : Anamaria Magdalena Tomşa, Andreea Liana Răchişan, Stanca Lucia Pandrea, Andreea Benea, Ana Uifălean, Corina Toma, Roxana Popa, Alina Elena Pârvu, Lia Monica Junie
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Vitamin C : CK(6066) : AC(1408)
Diseases : Chemotherapy-Induced Kidney Damage : CK(289) : AC(145), Chemotherapy-Induced Toxicity: Gentamicin : CK(194) : AC(102)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Chemoprotective Agents : CK(4278) : AC(1621), Interleukin-10 upregulation : CK(1296) : AC(436), Renoprotective : CK(4544) : AC(1971)

Curcumin and vitamin D supplement attenuates knee osteoarthritis progression.

Pubmed Data : Nutrients. 2025 Jan 19 ;17(2). Epub 2025 Jan 19. PMID: 39861479
Article Published Date : Jan 18, 2025
Authors : Lokesh Kumar Mende, Yaswanth Kuthati, Chih-Shung Wong
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Vitamin D : CK(11762) : AC(1712)
Diseases : Osteoarthritis: Knee : CK(2345) : AC(276), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Analgesics : CK(9680) : AC(1472), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Interleukin-10 upregulation : CK(1296) : AC(436)

Curcumin as a potential protective compound against cardiac diseases.

Pubmed Data : Pharmacol Res. 2017 Mar 6 ;119:373-383. Epub 2017 Mar 6. PMID: 28274852
Article Published Date : Mar 05, 2017
Authors : Shuai Jiang, Jing Han, Tian Li, Zhenlong Xin, Zhiqiang Ma, Wencheng Di, Wei Hu, Bing Gong, Shouyin Di, Dongjin Wang, Yang Yang
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cardiovascular Diseases : CK(17333) : AC(2878)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin as a therapeutic agent in leukemia.

Pubmed Data : J Cell Physiol. 2019 Aug ;234(8):12404-12414. Epub 2019 Jan 4. PMID: 30609023
Article Published Date : Jul 31, 2019
Authors : Hamideh Kouhpeikar, Alexandra E Butler, Faeze Bamian, George E Barreto, Muhammed Majeed, Amirhossein Sahebkar
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Leukemia : CK(2094) : AC(910)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Chemotherapeutic : CK(4390) : AC(1635), Immunomodulatory : CK(6531) : AC(2360)

Curcumin as prospective anti-aging natural compound: focus on brain.

Pubmed Data : Molecules. 2021 Aug 7 ;26(16). Epub 2021 Aug 7. PMID: 34443381
Article Published Date : Aug 06, 2021
Authors : Tarek Benameur, Raffaella Soleti, Maria Antonietta Panaro, Maria Ester La Torre, Vincenzo Monda, Giovanni Messina, Chiara Porro
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aging: Brain : CK(1118) : AC(268)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin attenuated neurotoxicity in sporadic animal model of Alzheimer's disease.

Pubmed Data : Molecules. 2021 May 18 ;26(10). Epub 2021 May 18. PMID: 34070220
Article Published Date : May 17, 2021
Authors : Ines ELBini-Dhouib, Raoudha Doghri, Amenallah Ellefi, Imen Degrach, Najet Srairi-Abid, Asma Gati
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alzheimer's Disease : CK(5355) : AC(2210)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin attenuates angiotensin II-induced abdominal aortic aneurysm.

Pubmed Data : Evid Based Complement Alternat Med. 2014 ;2014:270930. Epub 2014 Nov 6. PMID: 25431606
Article Published Date : Dec 31, 2013
Authors : QingQing Hao, Xu Chen, XiaoYu Wang, Bo Dong, ChuanHua Yang
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aneurysm: Aortic : CK(125) : AC(40)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin attenuates both acute and chronic immune nephritis.

Pubmed Data : Int J Mol Sci. 2020 Mar 4 ;21(5). Epub 2020 Mar 4. PMID: 32143311
Article Published Date : Mar 03, 2020
Authors : Tianfu Wu, Bindiya Marakkath, Yujin Ye, Elhaum Khobahy, Mei Yan, Jack Hutcheson, Jiankun Zhu, Xinjin Zhou, Chandra Mohan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Nephritis : CK(47) : AC(12)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Immunomodulatory : CK(6531) : AC(2360)

Curcumin attenuates retinal oxidative stress and inflammation in diabetes.

Pubmed Data : Nutr Metab (Lond). 2007;4:8. Epub 2007 Apr 16. PMID: 17437639
Article Published Date : Jan 01, 2007
Authors : Renu A Kowluru, Mamta Kanwar
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetic Retinopathy : CK(483) : AC(211)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin attenuates sarcopenia in chronic forced exercise executed aged mice.

Pubmed Data : J Agric Food Chem. 2021 May 5. Epub 2021 May 5. PMID: 33950680
Article Published Date : May 04, 2021
Authors : Da-Yeon Lee, Yoon-Seok Chun, Jong-Kyu Kim, Jeong-Ok Lee, Sae-Kwang Ku, Soon-Mi Shim
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Sarcopenia : CK(368) : AC(79)
Therapeutic Actions : Exercise : CK(6919) : AC(1026)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin could protect against the vascular side effects of methotrexate by preventing an increase in oxidative stress.

Pubmed Data : Can J Physiol Pharmacol. 2015 Nov 16:1-8. Epub 2015 Nov 16. PMID: 26571019
Article Published Date : Nov 15, 2015
Authors : Himanshu Sankrityayan, Anuradha S Majumdar
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Folic Acid : CK(1317) : AC(206)
Diseases : Drug Toxicity: Methotrexate : CK(194) : AC(100), Endothelial Dysfunction : CK(2733) : AC(581), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin encapsulation in geranium oil microemulsion elevates its antibacterial, antioxidant, anti-inflammatory, and anticancer activities.

Pubmed Data : ACS Omega. 2024 Feb 6 ;9(5):5624-5636. Epub 2024 Jan 23. PMID: 38343911
Article Published Date : Feb 05, 2024
Authors : Shahzadi Filza Hassan, Sajid Asghar, Ikram Ullah Khan, Rabia Munir, Syed Haroon Khalid
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Geranium : CK(88) : AC(36)
Diseases : Escherichia coli Infections : CK(603) : AC(450), Inflammation : CK(16108) : AC(5498), Liver Cancer : CK(3119) : AC(1641), Staphylococcus aureus infection : CK(776) : AC(576)
Pharmacological Actions : Anti-Bacterial Agents : CK(4228) : AC(1989), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin exerts protective effects against valproic acid-induced testicular damage.

Pubmed Data : Iran J Basic Med Sci. 2025 ;28(2):230-236. PMID: 39850114
Article Published Date : Dec 31, 2024
Authors : Eda Dokumacioglu, Hatice Iskender, Kubra Asena Terim Kapakin, İSmail Bolat, Behzat Mokhtare, Ali Dogan Omur, Armagan Hayirli
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Testicular Injury: Chemical/Metal Induced : CK(774) : AC(385)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin exhibits anti-inflammatory properties in rat brain homegenates.

Pubmed Data : Mol Cell Biochem. 1994 Nov 9;140(1):73-9. PMID: 7877600
Article Published Date : Nov 09, 1994
Authors : D V Rajakumar, M N Rao
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Brain Inflammation : CK(1784) : AC(928), Lipid Peroxidation : CK(2057) : AC(806)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin exhibits salutary effects against adenine-induced chronic kidney disease in rats by reducing inflammation and oxidative stress.

Pubmed Data : Basic Clin Pharmacol Toxicol. 2017 May 31. Epub 2017 May 31. PMID: 28561324
Article Published Date : May 30, 2017
Authors : Badreldin H Ali, Suhail Al-Salam, Yousuf Al Suleimani, Jamila Al Kalbani, Shadia Al Bahlani, Mohammed Ashique, Priyadarsini Manoj, Buthaina Al Zhili, Nadia Al Abri, Heba T Naser, Javed Yasin, Abderrahim Nemmar, Mohamed Al Za'abi, Christina Hartmann, Nicole Schupp
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chronic Kidney Disease (CKD) : CK(1186) : AC(211)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Nrf2 activation : CK(3156) : AC(1794)

Curcumin has a potent anti-inflammatory and anti- oxidant effects against atherosclerosis.

Pubmed Data : Indian J Clin Biochem. 2021 Jan ;36(1):74-80. Epub 2019 Nov 19. PMID: 33505130
Article Published Date : Dec 31, 2020
Authors : Murooj L Majeed, Fadhaa A Ghafil, Ghizal Fatima, Najah R Hadi, Hind F Mahdi
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Atherosclerosis : CK(2063) : AC(778), Hypercholesterolemia : CK(2706) : AC(482)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin has a promising role as a cardioprotective agent against palmitate and high fat diet mediated cardiac dysfunction.

Pubmed Data : J Mol Cell Cardiol. 2015 Feb ;79:1-12. Epub 2014 Oct 16. PMID: 25444713
Article Published Date : Jan 31, 2015
Authors : Chunlai Zeng, Peng Zhong, Yunjie Zhao, Karvannan Kanchana, Yali Zhang, Zia A Khan, Subrata Chakrabarti, Lianpin Wu, Jingying Wang, Guang Liang
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Circulating Free Fatty Acids: Elevated : CK(3) : AC(2), High Fat Diet : CK(2040) : AC(984), Obesity : CK(11004) : AC(2672)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963), NF-kappaB Inhibitor : CK(5952) : AC(3464), Nrf2 activation : CK(3156) : AC(1794)

Curcumin has a protective role in cardiovascular diseases.

Pubmed Data : Int J Cardiol. 2009 Apr 3;133(2):145-51. Epub 2009 Feb 23. PMID: 19233493
Article Published Date : Apr 03, 2009
Authors : Wanwarang Wongcharoen, Arintaya Phrommintikul
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cardiovascular Diseases : CK(17333) : AC(2878)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Cardiovascular Agents : CK(215) : AC(35)

Curcumin has strong antioxidant, with anti-inflammatory, immunomodulatory and analgesic properties.

Pubmed Data : Int J Pharm Investig. 2014 Jul ;4(3):138-41. PMID: 25126527
Article Published Date : Jun 30, 2014
Authors : Radha A Deshmukh, Anjana S Bagewadi
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Stomatitis: Aphthous : CK(293) : AC(36)
Pharmacological Actions : Analgesics : CK(9680) : AC(1472), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Immunomodulatory : CK(6531) : AC(2360)

Curcumin in ophthalmology: Mechanisms, challenges, and emerging opportunities.

Pubmed Data : Molecules. 2025 Jan 21 ;30(3). Epub 2025 Jan 21. PMID: 39942561
Article Published Date : Jan 20, 2025
Authors : Adriana Ribeiro, Daniele Oliveira, Helena Cabral-Marques
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Eye Diseases : CK(2669) : AC(713)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin in the correction of oxidative and immune disorders during exercises.

Pubmed Data : Vopr Pitan. 2021 ;90(1):65-73. Epub 2021 Jan 20. PMID: 33740329
Article Published Date : Dec 31, 2020
Authors : O A Gizinger, A A Khisamova
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Muscle Damage: Exercise-Induced : CK(1101) : AC(137)
Therapeutic Actions : Exercise : CK(6919) : AC(1026)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin in the treatment of inflammation and oxidative stress responses in traumatic brain injury.

Pubmed Data : Front Neurol. 2024 ;15:1380353. Epub 2024 May 10. PMID: 38798711
Article Published Date : Dec 31, 2023
Authors : Jinfeng Guo, Zhengjie Li, Yun Yao, Lei Fang, Mingdi Yu, Zuhui Wang
Study Type : Meta Analysis, Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Brain Injury: Traumatic : CK(383) : AC(131)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin inhibits neuronal apoptosis and alleviates oxidative stress and inflammation in neurons subjected to Oxyhemoglobin.

Pubmed Data : Brain Res Bull. 2015 Nov 10 ;120:34-40. Epub 2015 Nov 10. PMID: 26551062
Article Published Date : Nov 09, 2015
Authors : Xia Li, Lei Zhao, Liang Yue, Haixiao Liu, Xiangmin Yang, Xinchuan Wang, Yan Lin, Yan Qu
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Subarachnoid hemorrhage : CK(206) : AC(72)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin is a potent therapeutic drug candidate for inflammatory and degenerative retinal and eye diseases.

Pubmed Data : Mol Nutr Food Res. 2013 Sep ;57(9):1557-68. Epub 2013 Feb 18. PMID: 23417969
Article Published Date : Aug 31, 2013
Authors : Lei-Lei Wang, Yue Sun, Kun Huang, Ling Zheng
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetic Retinopathy : CK(483) : AC(211), Glaucoma : CK(611) : AC(145), Inflammation : CK(16108) : AC(5498), Macular Degeneration : CK(604) : AC(173), Retinal Diseases : CK(146) : AC(60)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin is a promising candidate for preventing and controlling migraine.

Pubmed Data : Biomed Pharmacother. 2023 Aug ;164:114910. Epub 2023 May 22. PMID: 37216708
Article Published Date : Jul 31, 2023
Authors : Hajar Heidari, Mehrnaz Shojaei, Gholamreza Askari, Muhammed Majeed, Mohammad Bagherniya, George E Barreto, Amirhossein Sahebkar
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Inflammation : CK(16108) : AC(5498), Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Analgesics : CK(9680) : AC(1472), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin may be a novel treatment for neuroinflammation-mediated neurodegenerative disorders.

Pubmed Data : Int J Mol Med. 2018 Jan ;41(1):521-530. Epub 2017 Oct 27. PMID: 29115589
Article Published Date : Dec 31, 2017
Authors : Meiling Jin, Sun Young Park, Qian Shen, Yihong Lai, Xingmei Ou, Zhuo Mao, Dongxu Lin, Yangyang Yu, Weizhen Zhang
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Brain Inflammation : CK(1784) : AC(928)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Heme oxygenase-1 inducer : CK(63) : AC(43), Nrf2 activation : CK(3156) : AC(1794)

Curcumin may have therapeutic potential for bladder cancer patients via anti-inflammatory, antioxidant and anti-carcinogenic activities.

Pubmed Data : Oncol Rep. 2006 May;15(5):1225-31. PMID: 16596191
Article Published Date : May 01, 2006
Authors : Cheol Park, Gi Young Kim, Gun Do Kim, Byung Tae Choi, Yeong-Min Park, Yung Hyun Choi
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Bladder Cancer : CK(782) : AC(320)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anticarcinogenic Agents : CK(2152) : AC(1018), Antioxidants : CK(34551) : AC(14499)

Curcumin nanoformulations to combat aging-related diseases.

Pubmed Data : Ageing Res Rev. 2021 May 14 ;69:101364. Epub 2021 May 14. PMID: 34000462
Article Published Date : May 13, 2021
Authors : Maryam Mahjoob, Ursula Stochaj
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aging : CK(6221) : AC(1510)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin nanoparticles have the capacity to mitigate the renal toxicity induced by aluminum oxide nanoparticles.

Pubmed Data : Environ Toxicol. 2024 Aug 6. Epub 2024 Aug 6. PMID: 39105312
Article Published Date : Aug 05, 2024
Authors : Ehab Tousson, Ibrahim E T El-Sayed, Hebatalla Nashaat Elsharkawy, Amira S Ahmed
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aluminum Toxicity : CK(735) : AC(318)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Renoprotective : CK(4544) : AC(1971)
Problem Substances : Aluminum oxide : CK(20) : AC(10)

Curcumin oil has a protective effect against cisplatin-induced nephrotoxicity.

Pubmed Data : J Agric Food Chem. 2007 Dec 12;55(25):10150-5. Epub 2007 Nov 15. PMID: 18001039
Article Published Date : Dec 12, 2007
Authors : Anurag Kuhad, Sangeeta Pilkhwal, Sameer Sharma, Naveen Tirkey, Kanwaljit Chopra
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1246) : AC(601), Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Renoprotective : CK(4544) : AC(1971), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin on human health: A comprehensive systematic review and meta-analysis of 103 randomized controlled trials.

Pubmed Data : Phytother Res. 2024 Oct 31. Epub 2024 Oct 31. PMID: 39478418
Article Published Date : Oct 30, 2024
Authors : Ali Jafari, Maryam Abbastabar, Alireza Alaghi, Javad Heshmati, Francesca L Crowe, Mahdi Sepidarkish
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hypoglycemic Agents : CK(9221) : AC(2076), Hypolipidemic : CK(9173) : AC(2038)

Curcumin possesses anti-diabetic effects and mitigates diabetes complications

Pubmed Data : Curr Top Med Chem. 2015 Jun 19. Epub 2015 Jun 19. PMID: 26088351
Article Published Date : Jun 18, 2015
Authors : Seyed Fazel Nabavi, Raman Thiagarajan, Luca Rastrelli, Maria Daglia, Eduardo Sobarzo-Sanchez, Heshmatollah Alinezhad, Seyed Mohammad Nabavi
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetes Mellitus: Type 2 : CK(12953) : AC(2579), Diabetic Complications : CK(4678) : AC(1606)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Advanced Glycation End Products : CK(11) : AC(2)

Curcumin protected the liver from chronic-ethanol induced injury through attenuating oxidative stress

Pubmed Data : Pharmacogn Mag. 2015 Oct-Dec;11(44):707-715. PMID: 26600714
Article Published Date : Sep 30, 2015
Authors : Zhang E Xiong, Wei Guo Dong, Bao Ying Wang, Qiao Yun Tong, Zhong Yan Li
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alcoholic Liver Disease : CK(611) : AC(283)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Nrf2 activation : CK(3156) : AC(1794)

Curcumin protects glial cells and promotes a microglial anti-inflammatory phenotype by a mechanism that implicates HO-1 induction.

Pubmed Data : Mol Nutr Food Res. 2015 Sep ;59(9):1690-700. Epub 2015 Jun 30. PMID: 26047311
Article Published Date : Aug 31, 2015
Authors : Esther Parada, Izaskun Buendia, Elisa Navarro, Carlos Avendaño, Javier Egea, Manuela G López
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Brain: Oxidative Stress : CK(644) : AC(347), Brain Inflammation : CK(1784) : AC(928)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin protects intestinal mucosal barrier function of rat enteritis.

Pubmed Data : PLoS One. 2010;5(9):e12969. Epub 2010 Sep 24. PMID: 20885979
Article Published Date : Jan 01, 2010
Authors : Wei-Bing Song, Yuan-Yuan Wang, Fan-Su Meng, Qing-Hua Zhang, Jian-Ying Zeng, Li-Ping Xiao, Xin-Pei Yu, Dan-dan Peng, Lei Su, Bing Xiao, Zhen-Shu Zhang
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Intestinal Permeability : CK(249) : AC(63)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Gastroprotective : CK(1692) : AC(701)

Curcumin reduced or eliminated colonic tumor burden with limited effects on mucosal immune responses.

Pubmed Data : Inflamm Bowel Dis. 2015 Jul 25. Epub 2015 Jul 25. PMID: 26218141
Article Published Date : Jul 24, 2015
Authors : Rita-Marie T McFadden, Claire B Larmonier, Kareem W Shehab, Monica Midura-Kiela, Rajalakshmy Ramalingam, Christy A Harrison, David G Besselsen, John H Chase, J Gregory Caporaso, Christian Jobin, Fayez K Ghishan, Pawel R Kiela
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Colitis : CK(1542) : AC(735), Colon Cancer: Prevention : CK(192) : AC(64)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anticarcinogenic Agents : CK(2152) : AC(1018), Antioxidants : CK(34551) : AC(14499), Chemopreventive : CK(6580) : AC(2166)
Additional Keywords : Microbiota : CK(1256) : AC(346)

Curcumin reduces production of ROS and inflammatory mediators in HIV-1-gp120-stimulated microglia, and protects cortical neurons against HIV-1-mediated apoptosis.

Pubmed Data : PLoS One. 2013 ;8(8):e70565. Epub 2013 Aug 6. PMID: 23936448
Article Published Date : Dec 31, 2012
Authors : Luyan Guo, Yanyan Xing, Rui Pan, Mingliang Jiang, Zheng Gong, Liqing Lin, Junbing Wang, Guoyin Xiong, Jun Dong
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : HIV Infections : CK(1193) : AC(399), Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin significantly ameliorates disease symptoms in a Drosophila model of Huntington's disease.

Pubmed Data : Sci Rep. 2016 ;6:18736. Epub 2016 Jan 5. PMID: 26728250
Article Published Date : Dec 31, 2015
Authors : Anjalika Chongtham, Namita Agrawal
Study Type : Insect Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Huntington Disease : CK(222) : AC(103)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin significantly inhibited the formation of advanced glycation end products (AGEs).

Pubmed Data : Mol Med Rep. 2015 Dec 28. Epub 2015 Dec 28. PMID: 26718010
Article Published Date : Dec 27, 2015
Authors : Yan Ping Sun, Jun Fei Gu, Xiao Bin Tan, Chun Fei Wang, Xiao Bin Jia, Liang Feng, Ji Ping Liu
Study Type : Human In Vitro
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Advanced Glycation End products (AGE) : CK(589) : AC(249), Endothelial Dysfunction : CK(2733) : AC(581), Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Glycation Agents : CK(351) : AC(167), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin supplementation (Meriva ®) modulates inflammation, lipid peroxidation and gut microbiota composition in chronic kidney disease.

Pubmed Data : Nutrients. 2022 Jan 5 ;14(1). Epub 2022 Jan 5. PMID: 35011106
Article Published Date : Jan 04, 2022
Authors : Francesca Pivari, Alessandra Mingione, Giada Piazzini, Camilla Ceccarani, Emerenziana Ottaviano, Caterina Brasacchio, Michele Dei Cas, Margherita Vischi, Mario Gennaro Cozzolino, Paolo Fogagnolo, Antonella Riva, Giovanna Petrangolini, Luigi Barrea, Laura Di Renzo, Elisa Borghi, Paola Signorelli, Rita Paroni, Laura Soldati
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chronic Kidney Disease (CKD) : CK(1186) : AC(211), Inflammation : CK(16108) : AC(5498), Lipid Peroxidation : CK(2057) : AC(806)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Gastrointestinal Agents : CK(7657) : AC(2274)

Curcumin supplementation improves oxidative stress and inflammation biomarkers in patients undergoing hemodialysis.

Pubmed Data : Int Urol Nephrol. 2022 Mar 26. Epub 2022 Mar 26. PMID: 35347555
Article Published Date : Mar 25, 2022
Authors : Livia Alvarenga, Ludmila F M F Cardozo, Beatriz O Da Cruz, Bruna R Paiva, Denis Fouque, Denise Mafra
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Hemodialysis : CK(1256) : AC(130)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin treatment attenuates lipopolysaccharide induced liver injury.

Pubmed Data : Biomed Pharmacother. 2016 Jul 6 ;83:302-313. Epub 2016 Jul 6. PMID: 27393927
Article Published Date : Jul 05, 2016
Authors : Wenhui Zhong, Kejian Qian, Jibin Xiong, Ke Ma, Aizhong Wang, Yan Zou
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875), Sepsis : CK(1436) : AC(491)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin's mechanism of action against ischemic stroke.

Pubmed Data : PLoS One. 2023 ;18(1):e0280112. Epub 2023 Jan 4. PMID: 36598916
Article Published Date : Dec 31, 2022
Authors : Yangyang Wang, Guoxiu Zu, Ying Yu, Jiqin Tang, Tao Han, Chengdong Zhang
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Stroke: Ischemic : CK(1030) : AC(284)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin, silybin phytosome® and α-R-lipoic acid may confer therapeutic efficacy against chronic hepatitis.

Pubmed Data : Basic Clin Pharmacol Toxicol. 2015 Oct 12. Epub 2015 Oct 12. PMID: 26457982
Article Published Date : Oct 11, 2015
Authors : Shimaa O Ali, Hebatallah A Darwish, Nabila A Ismail
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid : CK(1501) : AC(366), Curcumin : CK(7239) : AC(3319)
Diseases : Chronic Hepatitis : CK(12) : AC(2)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Curcumin-galactomannoside complex offered significant hepatoprotective effects to attenuate alcohol induced alterations to hepatic function markers.

Pubmed Data : Biomed Res Int. 2018 ;2018:9159281. Epub 2018 Sep 23. PMID: 30345312
Article Published Date : Dec 31, 2017
Authors : Naveen T Krishnareddy, Jestin V Thomas, Saritha S Nair, Johannah N Mulakal, Balu P Maliakel, I M Krishnakumar
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alcohol Toxicity : CK(1235) : AC(480), Alcoholic Liver Disease : CK(611) : AC(283)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies.

Pubmed Data : Phytother Res. 2023 Jan 31. Epub 2023 Jan 31. PMID: 36720711
Article Published Date : Jan 30, 2023
Authors : Hajar Heidari, Mohammad Bagherniya, Muhammed Majeed, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Piperine : CK(600) : AC(258)
Diseases : Obesity : CK(11004) : AC(2672)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hypoglycemic Agents : CK(9221) : AC(2076), Hypolipidemic : CK(9173) : AC(2038)

Curcumin: A golden approach to healthy aging: A systematic review of the evidence.

Pubmed Data : Nutrients. 2024 Aug 15 ;16(16). Epub 2024 Aug 15. PMID: 39203857
Article Published Date : Aug 14, 2024
Authors : Yandra Cervelim Nunes, Nathalia M Mendes, Enzo Pereira de Lima, Amanda Chabrour Chehadi, Caroline Barbalho Lamas, Jesselina F S Haber, Manoela Dos Santos Bueno, Adriano Cressoni Araújo, Vitor C Strozze Catharin, Claudia Rucco P Detregiachi, Lucas Fornari Laurindo, Masaru Tanaka, Sandra Maria Barbalho, Maria JoséSanches Marin
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aging : CK(6221) : AC(1510), Cardiovascular Diseases : CK(17333) : AC(2878), Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716), Sarcopenia : CK(368) : AC(79)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Curcumin: A potential detoxifier against chemical and natural toxicants.

Pubmed Data : Phytother Res. 2025 Mar ;39(3):1494-1530. Epub 2025 Jan 24. PMID: 39853860
Article Published Date : Feb 28, 2025
Authors : Harsh Kumar, Rajni Dhalaria, Neetika Kimta, Shivani Guleria, Navneet Kumar Upadhyay, Eugenie Nepovimova, Daljeet Singh Dhanjal, Nidhi Sethi, Sivakumar Manickam
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemical Exposure : CK(112) : AC(40), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Detoxifier : CK(856) : AC(254)

Curcumin@Fe/tannic acid complex nanoparticles for inflammatory bowel disease treatment.

Pubmed Data : ACS Omega. 2024 Mar 26 ;9(12):14316-14322. Epub 2024 Mar 14. PMID: 38559927
Article Published Date : Mar 25, 2024
Authors : Jiman Jin, Xiuzhi Ye, Zhenfeng Huang, Shicui Jiang, Dini Lin
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Tannic Acid : CK(120) : AC(71)
Diseases : Inflammatory Bowel Diseases : CK(3196) : AC(926)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Gastrointestinal Agents : CK(7657) : AC(2274)

Curcuminoids from Curcuma Longa: New adjuvants for the treatment of crohn's disease and ulcerative colitis?

Pubmed Data : Crit Rev Food Sci Nutr. 2019 ;59(13):2136-2143. Epub 2018 Apr 12. PMID: 29565637
Article Published Date : Dec 31, 2018
Authors : Fernando Cunha Neto, Ledyane Taynara Marton, Sâmylla Vaz de Marqui, Tainah Aparecida Lima, Sandra Maria Barbalho
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Crohn's Disease : CK(242) : AC(55), Oxidative Stress : CK(14758) : AC(5716), Ulcerative Colitis : CK(1411) : AC(447)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Curcuminoids: Implication for inflammation and oxidative stress in cardiovascular diseases.

Pubmed Data : Phytother Res. 2019 Mar 4. Epub 2019 Mar 4. PMID: 30834628
Article Published Date : Mar 03, 2019
Authors : Cheng Li, Xiao Miao, Fengsheng Li, Binay Kumar Adhikari, Yucheng Liu, Jian Sun, Rong Zhang, Lu Cai, Quan Liu, Yonggang Wang
Study Type : Review
Additional Links
Substances : Bisdemethoxycurcumin : CK(123) : AC(71), Curcumin : CK(7239) : AC(3319), Demethoxycurcumin : CK(80) : AC(53)
Diseases : Cardiovascular Diseases : CK(17333) : AC(2878)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963)

Effects of nanocurcumin supplementation on metabolic syndrome.

Pubmed Data : Pharmacol Res. 2025 Mar ;213:107641. Epub 2025 Feb 1. PMID: 39894187
Article Published Date : Feb 28, 2025
Authors : Gofarana Wilar, Cecep Suhandi, Kohji Fukunaga, Masanori Shigeno, Ichiro Kawahata, Rizky Abdulah, Takuya Sasaki
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Hypertension : CK(9125) : AC(1361), Metabolic Syndrome X : CK(3095) : AC(546)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antihypertensive Agents : CK(7081) : AC(1029), Antioxidants : CK(34551) : AC(14499), Hypolipidemic : CK(9173) : AC(2038), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Effects of turmeric and its constituent curcumin on the metabolic syndrome.

Pubmed Data : J Integr Med. 2022 05 ;20(3):193-203. Epub 2022 Mar 1. PMID: 35292209
Article Published Date : Dec 31, 2021
Authors : Zeinab Vafaeipour, Bibi Marjan Razavi, Hossein Hosseinzadeh
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetes Mellitus: Type 2 : CK(12953) : AC(2579)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antihypertensive Agents : CK(7081) : AC(1029), Antioxidants : CK(34551) : AC(14499), Hypolipidemic : CK(9173) : AC(2038)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Epigenetics/epigenomics and prevention by curcumin of early stages of inflammatory-driven colon cancer.

Pubmed Data : Mol Carcinog. 2020 Feb ;59(2):227-236. Epub 2019 Dec 9. PMID: 31820492
Article Published Date : Jan 31, 2020
Authors : Renyi Wu, Lujing Wang, Ran Yin, Rasika Hudlikar, Shanyi Li, Hsiao-Chen D Kuo, Rebecca Peter, Davit Sargsyan, Yue Guo, Xia Liu, Ah-Ng T Kong
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Colon Cancer : CK(1920) : AC(1203), Gastrointestinal Inflammation : CK(330) : AC(157)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Chemoprotective Agents : CK(4278) : AC(1621)
Additional Keywords : Epigenetic Modification In Cancer : CK(189) : AC(126)

Findings highlight the therapeutic potential of these compounds in mitigating tissue damage and inflammation associated with ovarian transplant.

Pubmed Data : Exp Clin Transplant. 2024 Sep ;22(9):706-716. PMID: 39431839
Article Published Date : Aug 31, 2024
Authors : Papatya Keles, Tansel Sapmaz, Kubra Basol Baki, Sude Topkaraoglu, Esra Erdem, Kubra Sevgin, Sibel Kuras, Mahmud Esad Pence, Selman Aktas, Burak Karip
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Gallic Acid : CK(341) : AC(212)
Diseases : Organ Transplantation : CK(59) : AC(24), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Interleukin-6 Downregulation : CK(9337) : AC(3613)

Hepatoprotective effect of curcumin nano-lipid carrier against cypermethrin toxicity.

Pubmed Data : Molecules. 2023 Jan 16 ;28(2). Epub 2023 Jan 16. PMID: 36677938
Article Published Date : Jan 15, 2023
Authors : Sohail Hussain, Mohammad Ashafaq, Saeed Alshahrani, Ibrahim A M Bokar, Rahimullah Siddiqui, Mohammad Intakhab Alam, Manal Mohamed Elhassan Taha, Yosif Almoshari, Saad S Alqahtani, Rayan A Ahmed, Abdulmajeed M Jali, Marwa Qadri
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Oxidative Stress : CK(14758) : AC(5716), Pesticide Toxicity : CK(1467) : AC(478)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Interleukin-6 Downregulation : CK(9337) : AC(3613), NF-kappaB Inhibitor : CK(5952) : AC(3464), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)
Problem Substances : Pesticides : CK(2401) : AC(488)

Impact of curcumin, quercetin, or resveratrol on the pathophysiology of endometriosis.

Pubmed Data : Phytother Res. 2022 Jun ;36(6):2416-2433. Epub 2022 May 18. PMID: 35583746
Article Published Date : May 31, 2022
Authors : Mariana Hipólito-Reis, Ana Catarina Neto, Delminda Neves
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Quercetin : CK(1876) : AC(855), Resveratrol : CK(3228) : AC(1513)
Diseases : Endometriosis : CK(579) : AC(159)
Pharmacological Actions : Angiogenesis Inhibitors : CK(724) : AC(481), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Antiproliferative : CK(10001) : AC(7491)

Impacts of curcumin treatment on experimental sepsis.

Pubmed Data : Oxid Med Cell Longev. 2023 ;2023:2252213. Epub 2023 Jan 30. PMID: 36756300
Article Published Date : Dec 31, 2022
Authors : Barbara Martins Vieira, Marcos Antonio Ferreira Caetano, Mara Taís de Carvalho, Felipe Dos Santos Arruda, Fernanda Dias Tomé, Jordana Fernandes de Oliveira, Danilo Figueiredo Soave, Jonathas Xavier Pereira, Mara Rubia Nunes Celes
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Oxidative Stress : CK(14758) : AC(5716), Sepsis : CK(1436) : AC(491)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Immunomodulatory : CK(6531) : AC(2360)

Inhibition of curcumin on influenza A virus infection and influenzal pneumonia.

Pubmed Data : Int Immunopharmacol. 2018 Jan ;54:177-187. Epub 2017 Nov 15. PMID: 29153953
Article Published Date : Dec 31, 2017
Authors : Jianping Dai, Liming Gu, Yun Su, Qianwen Wang, Ying Zhao, Xiaoxua Chen, Huixiong Deng, Weizhong Li, Gefei Wang, Kangsheng Li
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Influenza A : CK(582) : AC(204), Oxidative Stress : CK(14758) : AC(5716), Pneumonia : CK(1101) : AC(171)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Antiviral Agents : CK(3095) : AC(1702), Nrf2 activation : CK(3156) : AC(1794)

Is curcumin useful in the treatment and prevention of the tendinopathy and myotendinous junction injury.

Pubmed Data : Nutrients. 2023 Jan 12 ;15(2). Epub 2023 Jan 12. PMID: 36678255
Article Published Date : Jan 11, 2023
Authors : Alfredo Córdova, Franchek Drobnic, David Noriega-González, Alberto Caballero-García, Enrique Roche, Melchor Alvarez-Mon
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Inflammation : CK(16108) : AC(5498), Tendinopathy : CK(164) : AC(27)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Liposomal curcumin may be useful for the prevention of copper sulphate induced liver injury.

Pubmed Data : Dose Response. 2018 Jul-Sep;16(3):1559325818790869. Epub 2018 Aug 9. PMID: 30116168
Article Published Date : Jun 30, 2018
Authors : Ahlam Alhusaini, Laila Fadda, Iman Hassan, Hanaa M Ali, Njood Alsaadan, Nouf Aldowsari, Azizah Aldosari, Bshayer Alharbi
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Copper Toxicity : CK(49) : AC(23)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Natural Substances Versus Drugs : CK(2806) : AC(560)

Mechanistic insights of hepatoprotective effects of curcumin.

Pubmed Data : Food Chem Toxicol. 2019 Feb ;124:182-191. Epub 2018 Dec 5. PMID: 30529260
Article Published Date : Jan 31, 2019
Authors : Haroon Khan, Hammad Ullah, Seyed M Nabavi
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Chemically-Induced Liver Damage : CK(2304) : AC(1089), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Medical therapy of asthenoteratospermia with curcumin nanomicelle supplement could improve quality of semen parameters.

Pubmed Data : Phytother Res. 2018 Mar ;32(3):514-521. Epub 2017 Nov 28. PMID: 29193350
Article Published Date : Feb 28, 2018
Authors : Fatemeh Alizadeh, Maryam Javadi, Ali Akbar Karami, Fereshteh Gholaminejad, Maria Kavianpour, Hossein Khadem Haghighian
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Infertility: Male : CK(1757) : AC(452)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Malondialdehyde Down-regulation : CK(3028) : AC(992), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Molecular mechanisms of curcumin in neuroinflammatory disorders.

Pubmed Data : Endocr Metab Immune Disord Drug Targets. 2019 ;19(3):247-258. PMID: 30488803
Article Published Date : Dec 31, 2018
Authors : Mahsa Hatami, Mina Abdolahi, Neda Soveyd, Mahmoud Djalali, Mansoureh Togha, Niyaz Mohammadzadeh Honarvar
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Brain Inflammation : CK(1784) : AC(928)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Interleukin-1 beta downregulation : CK(6063) : AC(2940), Neuroprotective Agents : CK(20061) : AC(7949), NF-kappaB Inhibitor : CK(5952) : AC(3464), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Molecular mechanisms underlying curcumin-mediated therapeutic effects in type 2 diabetes and cancer.

Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:9698258. Epub 2018 Mar 20. PMID: 29743988
Article Published Date : Dec 31, 2017
Authors : Marzena Wojcik, Michal Krawczyk, Pawel Wojcik, Katarzyna Cypryk, Lucyna Alicja Wozniak
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cancers: All : CK(36404) : AC(14363), Diabetes Mellitus: Type 2 : CK(12953) : AC(2579)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Antiproliferative : CK(10001) : AC(7491), Chemopreventive : CK(6580) : AC(2166), Hypoglycemic Agents : CK(9221) : AC(2076)

Multiple mechanisms of curcumin targeting spinal cord injury.

Pubmed Data : Biomed Pharmacother. 2023 Jan 14 ;159:114224. Epub 2023 Jan 14. PMID: 36641925
Article Published Date : Jan 13, 2023
Authors : Guangjin Gu, Jie Ren, Bin Zhu, Zhongju Shi, Shiqing Feng, Zhijian Wei
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Spinal Cord Injuries : CK(890) : AC(347)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Nanocurcumin in myocardial infarction therapy: emerging trends and future directions.

Pubmed Data : Front Bioeng Biotechnol. 2024 ;12:1511331. Epub 2025 Jan 8. PMID: 39845374
Article Published Date : Dec 31, 2023
Authors : Mei Lv, Qing Sun, Yilin Yu, Jinwei Bao
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Myocardial Infarction : CK(2132) : AC(509)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963)

Nanocurcumin preserves kidney function and haematology parameters in DMBA-induced ovarian cancer treated with cisplatin.

Pubmed Data : Pharm Biol. 2023 Dec ;61(1):298-305. PMID: 36708211
Article Published Date : Nov 30, 2023
Authors : Melva Louisa, Erico Wanafri, Wawaimuli Arozal, Ni Made Dwi Sandhiutami, Ahmad Muhammad Basalamah
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1246) : AC(601), Ovarian Cancer : CK(1029) : AC(509)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Chemoprotective Agents : CK(4278) : AC(1621), Renoprotective : CK(4544) : AC(1971)

Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin.

Pubmed Data : Colloids Surf B Biointerfaces. 2017 Feb 1 ;150:223-241. Epub 2016 Nov 30. PMID: 27918967
Article Published Date : Jan 31, 2017
Authors : Zahid Hussain, Hnin Ei Thu, Shiow-Fern Ng, Shahzeb Khan, Haliza Katas
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Wound Healing : CK(4555) : AC(1412)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Natural products for promoting joint health and managing osteoarthritis.

Pubmed Data : Curr Rheumatol Rep. 2018 Sep 19 ;20(11):72. Epub 2018 Sep 19. PMID: 30232562
Article Published Date : Sep 18, 2018
Authors : Yves Henrotin, Ali Mobasheri
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Frankincense : CK(1021) : AC(260), Pycnogenol (Pine Bark) : CK(1254) : AC(223)
Diseases : Osteoarthritis : CK(2225) : AC(627)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

NPs-Cur enhance the action of curcumin on several pathways implicated in the pathophysiology of Alzheimer's disease.

Pubmed Data : Mol Pharm. 2015 Dec 23. Epub 2015 Dec 23. PMID: 26618861
Article Published Date : Dec 22, 2015
Authors : Ghislain Djiokeng Paka, Sihem Doggui, Ahlem Zaghmi, Ramia Safar, Lé Dao, Andreas Reisch, Andrey Klymchenko, V Gaëlle Roullin, Olivier Joubert, Charles Ramassamy
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alzheimer's Disease : CK(5355) : AC(2210)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Old but fancy: Curcumin in ulcerative colitis-current overview.

Pubmed Data : Nutrients. 2022 Dec 9 ;14(24). Epub 2022 Dec 9. PMID: 36558408
Article Published Date : Dec 08, 2022
Authors : Aleksandra Pituch-Zdanowska, Łukasz Dembiński, Aleksandra Banaszkiewicz
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Inflammation : CK(16108) : AC(5498), Ulcerative Colitis : CK(1411) : AC(447)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for murine colitis.

Pubmed Data : J Nanobiotechnology. 2022 Apr 29 ;20(1):206. Epub 2022 Apr 29. PMID: 35488343
Article Published Date : Apr 28, 2022
Authors : Cui Liu, Xiangji Yan, Yujie Zhang, Mei Yang, Yana Ma, Yuanyuan Zhang, Qiuran Xu, Kangsheng Tu, Mingzhen Zhang
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Colitis : CK(1542) : AC(735), Inflammation : CK(16108) : AC(5498), Ulcerative Colitis : CK(1411) : AC(447)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), NF-kappaB Inhibitor : CK(5952) : AC(3464)
Additional Keywords : Exosomes : CK(385) : AC(232)

Polymerized nano-curcumin has significant effects on the EAE scores and myelin repair mechanisms in an animal model of multiple sclerosis.

Pubmed Data : Neuropharmacology. 2015 Dec ;99:156-67. Epub 2015 Jul 23. PMID: 26211978
Article Published Date : Nov 30, 2015
Authors : Maryam Mohajeri, Majid Sadeghizadeh, Farhood Najafi, Mohammad Javan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Demyelinating Diseases : CK(3227) : AC(780), Multiple Sclerosis : CK(2432) : AC(557)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949), Remyelination : CK(24) : AC(13)
Additional Keywords : Gene Expression Regulation : CK(1401) : AC(623)

Prebiotic effect of berberine and curcumin Is associated with the improvement of obesity.

Pubmed Data : Nutrients. 2021 Apr 24 ;13(5). Epub 2021 Apr 24. PMID: 33923174
Article Published Date : Apr 23, 2021
Authors : Audrey M Neyrinck, Cándido Robles Sánchez, Julie Rodriguez, Patrice D Cani, Laure B Bindels, Nathalie M Delzenne
Study Type : Animal Study
Additional Links
Substances : Berberine : CK(2483) : AC(1079), Curcumin : CK(7239) : AC(3319)
Diseases : Obesity : CK(11004) : AC(2672)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Gastrointestinal Agents : CK(7657) : AC(2274)
Additional Keywords : Anti-Obesity Agents : CK(5172) : AC(1320)

Protective effect of curcumin against microplastic and nanoplastics toxicity.

Pubmed Data : Int J Environ Health Res. 2024 Aug 19:1-40. Epub 2024 Aug 19. PMID: 39161080
Article Published Date : Aug 18, 2024
Authors : Habibeh Mashayekhi-Sardoo, Samaneh Sepahi, Adel Ghorani-Azam, Hedyeh Askarpour, Thomas P Johnston, Amirhossein Sahebkar
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Microplastic Toxicity : CK(1075) : AC(509)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)
Problem Substances : Nano Plastic-and Micro-Particles : CK(557) : AC(257)

Protective effects of curcumin on ischemia/reperfusion injury.

Pubmed Data : Phytother Res. 2022 Sep 19. Epub 2022 Sep 19. PMID: 36123613
Article Published Date : Sep 18, 2022
Authors : Malihe Mohamadian, Negin Parsamanesh, Hossein Chiti, Thozhukat Sathyapalan, Amirhossein Sahebkar
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Ischemia : CK(626) : AC(325)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Radioprotective role of natural polyphenols: from sources to mechanisms.

Pubmed Data : Anticancer Agents Med Chem. 2021 Apr 18. Epub 2021 Apr 18. PMID: 33874875
Article Published Date : Apr 17, 2021
Authors : Muhammad Adnan, Azhar Rasul, Muhammad A Shah, Ghulam Hussain, Muhammad Asrar, Ammara Riaza, Iqra Sarfraza, Arif Hussaina, Khatereh Khorsandid, Ngit S Laie, Syed M Hussaina
Study Type : Animal Study
Additional Links
Substances : Apigenin : CK(681) : AC(392), Caffeic acid phenethyl ester : CK(284) : AC(172), Curcumin : CK(7239) : AC(3319), EGCG (Epigallocatechin gallate) : CK(1587) : AC(820), Epicatechin : CK(67) : AC(36), Gallic Acid : CK(341) : AC(212), Polyphenols : CK(2736) : AC(1003), Quercetin : CK(1876) : AC(855), Resveratrol : CK(3228) : AC(1513), Rutin : CK(463) : AC(223), Silibinin : CK(460) : AC(231)
Diseases : Silibinin : CK(460) : AC(231)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Radioprotective : CK(2398) : AC(713)

Reductive metabolites of curcumin and their therapeutic effects.

Pubmed Data : Heliyon. 2020 Nov ;6(11):e05469. Epub 2020 Nov 12. PMID: 33241148
Article Published Date : Oct 31, 2020
Authors : Achyut Pandey, Maya Chaturvedi, Shruti Mishra, Pramod Kumar, Pallavi Somvanshi, Rupesh Chaturvedi
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cancers: All : CK(36404) : AC(14363), Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Chemotherapeutic : CK(4390) : AC(1635), Immunomodulatory : CK(6531) : AC(2360)

Review of the effects and mechanism of curcumin in the treatment of inflammatory bowel disease.

Pubmed Data : Front Pharmacol. 2022 ;13:908077. Epub 2022 Jun 20. PMID: 35795556
Article Published Date : Dec 31, 2021
Authors : Yuan Lin, Hengjian Liu, Lingling Bu, Chen Chen, Xiaofeng Ye
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Inflammatory Bowel Diseases : CK(3196) : AC(926)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Gastrointestinal Agents : CK(7657) : AC(2274)

Role of Polyphenols in alleviating Alzheimer's disease: A Review

Pubmed Data : Curr Med Chem. 2022 Dec 2. Epub 2022 Dec 2. PMID: 36476438
Article Published Date : Dec 01, 2022
Authors : Tharsius Raja William Raja, Veeramuthu Duraipandiyan, Savarimuthu Ignacimuthu, Udaiyappan Janakiraman, Soosaimanickam Maria Packiam
Study Type : Review
Additional Links
Substances : Catechin : CK(965) : AC(313), Curcumin : CK(7239) : AC(3319), Hesperidin : CK(953) : AC(360), Kaempferol : CK(354) : AC(229), Polyphenols : CK(2736) : AC(1003), Quercetin : CK(1876) : AC(855), Resveratrol : CK(3228) : AC(1513)
Diseases : Alzheimer's Disease : CK(5355) : AC(2210)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Short-term adjunctive therapy with curcuminoids can suppress systemic inflammation in patients suffering from SM-induced chronic pulmonary complications.

Pubmed Data : Drug Res (Stuttg). 2014 Sep 30. Epub 2014 Sep 30. PMID: 25268878
Article Published Date : Sep 29, 2014
Authors : Y Panahi, M Ghanei, S Bashiri, A Hajihashemi, A Sahebkar
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemical Weapon Agent Injury : CK(26) : AC(6), Chemical Weapon Agent Injury: Sulfur Mustard : CK(62) : AC(8)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Short-term supplementation with curcumin improves liver fat and transaminase levels in patients with NAFLD.

Pubmed Data : Drug Res (Stuttg). 2017 Apr ;67(4):244-251. Epub 2017 Feb 3. PMID: 28158893
Article Published Date : Mar 31, 2017
Authors : Yunes Panahi, Parisa Kianpour, Reza Mohtashami, Ramezan Jafari, Luis E Simental-Mendía, Amirhossein Sahebkar
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Polyphenols : CK(2736) : AC(1003)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Stem cell therapy: curcumin does the trick.

Pubmed Data : Phytother Res. 2019 Nov ;33(11):2927-2937. Epub 2019 Aug 26. PMID: 31452263
Article Published Date : Oct 31, 2019
Authors : Simin Sharifi, Sepideh Zununi Vahed, Elham Ahmadian, Solmaz Maleki Dizaj, Atefeh Abedi, Seyed Mahdi Hosseiniyan Khatibi, Mohammad Samiei
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Wound Healing : CK(4555) : AC(1412)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

The beneficial effects of curcumin on aging and age-related diseases.

Pubmed Data : Front Aging Neurosci. 2025 ;17:1533963. Epub 2025 Jan 20. PMID: 39906716
Article Published Date : Dec 31, 2024
Authors : Ying He, Yongqing Liu, Min Zhang
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aging : CK(6221) : AC(1510)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), NF-kappaB Inhibitor : CK(5952) : AC(3464)

The combination of curcumin and berberine exhibited better ameliorative effects in treating NAFLD than lovastatin.

Pubmed Data : Biomed Pharmacother. 2018 Jan 17 ;99:325-333. Epub 2018 Jan 17. PMID: 29353208
Article Published Date : Jan 16, 2018
Authors : Wu-Wen Feng, Shuang-Yu Kuang, Can Tu, Zhi-Jie Ma, Jing-Yao Pang, Yan-Hui Wang, Qing-Ce Zang, Ta-Si Liu, Yan-Ling Zhao, Xiao-He Xiao, Jia-Bo Wang
Study Type : Animal Study
Additional Links
Substances : Berberine : CK(2483) : AC(1079), Curcumin : CK(7239) : AC(3319)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Superiority of Natural Substances versus Drugs : CK(1875) : AC(394)

The current study summarizes the reported knowledge on therapeutic potential of curcumin against multiple sclerosis.

Pubmed Data : Neurol Sci. 2017 Oct 27. Epub 2017 Oct 27. PMID: 29079885
Article Published Date : Oct 26, 2017
Authors : Munibah Qureshi, Ebtesam A Al-Suhaimi, Fazli Wahid, Omer Shehzad, Adeeb Shehzad
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Multiple Sclerosis : CK(2432) : AC(557)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

The effects of curcumin on diabetes mellitus: a systematic review.

Pubmed Data : Front Endocrinol (Lausanne). 2021 ;12:669448. Epub 2021 May 3. PMID: 34012421
Article Published Date : Dec 31, 2020
Authors : Ledyane Taynara Marton, Laís Maria Pescinini-E-Salzedas, Maria Eduarda Côrtes Camargo, Sandra M Barbalho, Jesselina F Dos Santos Haber, Renata Vargas Sinatora, Claudia Rucco Penteado Detregiachi, Raul J S Girio, Daniela Vieira Buchaim, Patricia Cincotto Dos Santos Bueno
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetes Mellitus: Type 1 : CK(2032) : AC(611), Diabetes Mellitus: Type 2 : CK(12953) : AC(2579)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anticholesteremic Agents : CK(4093) : AC(669), Antioxidants : CK(34551) : AC(14499)

The effects of curcumin on inflammasome: latest update.

Pubmed Data : Molecules. 2023 Jan 11 ;28(2). Epub 2023 Jan 11. PMID: 36677800
Article Published Date : Jan 10, 2023
Authors : Tarek Benameur, Socorro Vanesca Frota Gaban, Giulia Giacomucci, Francesca Martina Filannino, Teresa Trotta, Rita Polito, Giovanni Messina, Chiara Porro, Maria Antonietta Panaro
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Arthritis : CK(5826) : AC(1505), Inflammation : CK(16108) : AC(5498), Neurodegenerative Diseases : CK(13103) : AC(4279), Respiratory Diseases : CK(826) : AC(151)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Interleukin-18 down-regulation : CK(372) : AC(183), Interleukin-1 beta downregulation : CK(6063) : AC(2940)

The effects of curcumin plus piperine co-administration on inflammation and oxidative stress.

Pubmed Data : Curr Med Chem. 2024 Mar 29. Epub 2024 Mar 29. PMID: 38561618
Article Published Date : Mar 28, 2024
Authors : Hossein Hosseini, Farideh Ghavidel, Arezoo Rajabian, Masoud Homayouni-Tabrizi, Muhammed Majeed, Amirhossein Sahebkar
Study Type : Meta Analysis, Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Piperine : CK(600) : AC(258)
Diseases : Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

The evidence suggests a protective effect of curcumin in the control of epileptic seizures.

Pubmed Data : Adv Exp Med Biol. 2021 ;1291:363-373. PMID: 34331701
Article Published Date : Dec 31, 2020
Authors : Fatemeh Forouzanfar, Muhammed Majeed, Tannaz Jamialahmadi, Amirhosein Sahebkar
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Epilepsy : CK(1199) : AC(327)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Immunomodulatory : CK(6531) : AC(2360), Neuroprotective Agents : CK(20061) : AC(7949)

The impact of curcumin on immune response: an immunomodulatory strategy to treat sepsis.

Pubmed Data : Int J Mol Sci. 2022 Nov 25 ;23(23). Epub 2022 Nov 25. PMID: 36499036
Article Published Date : Nov 24, 2022
Authors : Alessandro Allegra, Giuseppe Mirabile, Roberta Ettari, Giovanni Pioggia, Sebastiano Gangemi
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Sepsis : CK(1436) : AC(491)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Immunomodulatory : CK(6531) : AC(2360)

The information presented in this paper identifies curcumin as a promising renoprotective molecule against renal injury.

Pubmed Data : Redox Biol. 2013 ;1:448-56. Epub 2013 Sep 17. PMID: 24191240
Article Published Date : Dec 31, 2012
Authors : Joyce Trujillo, Yolanda Irasema Chirino, Eduardo Molina-Jijón, Ana Cristina Andérica-Romero, Edilia Tapia, José Pedraza-Chaverrí
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Damage : CK(4109) : AC(1872), Liver Damage: Drug-Induced : CK(651) : AC(285), Liver Disease : CK(367) : AC(117), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Chemoprotective Agents : CK(4278) : AC(1621), Renoprotective : CK(4544) : AC(1971)

The multifaceted role of curcumin in advanced nanocurcumin form in the treatment and management of chronic disorders.

Pubmed Data : Molecules. 2021 Nov 24 ;26(23). Epub 2021 Nov 24. PMID: 34885693
Article Published Date : Nov 23, 2021
Authors : Priti Tagde, Pooja Tagde, Fahadul Islam, Sandeep Tagde, Muddaser Shah, Zareen Delawar Hussain, Md Habibur Rahman, Agnieszka Najda, Ibtesam S Alanazi, Mousa O Germoush, Hanan R H Mohamed, Mardi M Algandaby, Mohammed Z Nasrullah, Natalia Kot, Mohamed M Abdel-Daim
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cancers: All : CK(36404) : AC(14363), Chronic Disease : CK(216) : AC(57), Neurodegenerative Diseases : CK(13103) : AC(4279)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

The potential therapeutic effects of curcumin on pregnancy complications.

Pubmed Data : IUBMB Life. 2020 Oct 27. Epub 2020 Oct 27. PMID: 33107698
Article Published Date : Oct 26, 2020
Authors : Zahra Ghaneifar, Zahra Yousefi, Fatemeh Tajik, Banafsheh Nikfar, Fatemeh Ghalibafan, Elham Abdollahi, Amir Abbas Momtazi-Borojeni
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Pregnancy Complications : CK(662) : AC(89)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

The potential use of a curcumin-piperine combination as an antimalarial agent.

Pubmed Data : J Trop Med. 2021 ;2021:9135617. Epub 2021 Oct 11. PMID: 34671402
Article Published Date : Dec 31, 2020
Authors : Shafia Khairani, Nisa Fauziah, Hesti Lina Wiraswati, Ramdan Panigoro, Endang Yuni Setyowati, Afiat Berbudi
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Piperine : CK(600) : AC(258)
Diseases : Malaria : CK(303) : AC(135)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antimalarials : CK(125) : AC(78), Antioxidants : CK(34551) : AC(14499)

The preventive and therapeutic potential of polyphenolic nutraceuticals in Alzheimer's disease.

Pubmed Data : Adv Protein Chem Struct Biol. 2017 ;108:33-57. Epub 2017 Mar 22. PMID: 28427563
Article Published Date : Dec 31, 2016
Authors : Yousef Sawikr, Nagendra Sastry Yarla, Ilaria Peluso, Mohammad Amjad Kamal, Gjumrakch Aliev, Anupam Bishayee
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Flavonoids : CK(4698) : AC(2176), Piperine : CK(600) : AC(258), Polyphenols : CK(2736) : AC(1003), Resveratrol : CK(3228) : AC(1513)
Diseases : Alzheimer's Disease : CK(5355) : AC(2210), Brain Inflammation : CK(1784) : AC(928)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), NF-kappaB Inhibitor : CK(5952) : AC(3464)

The significant role of nutraceutical compounds in ulcerative colitis treatment.

Pubmed Data : Curr Med Chem. 2021 Dec 27. Epub 2021 Dec 27. PMID: 34961429
Article Published Date : Dec 26, 2021
Authors : Azzurra Chiara De Maio, Giovanna Basile, Domenico Iacopetta, Alessia Catalano, Jessica Ceramella, Danilo Cafaro, Carmela Saturnino, Maria Stefania Sinicropi
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Naringenin : CK(704) : AC(394), Oleuropein : CK(322) : AC(202)
Diseases : Ulcerative Colitis : CK(1411) : AC(447)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

The use of curcumin for the Ttreatment of renal disorders.

Pubmed Data : Adv Exp Med Biol. 2021 ;1291:327-343. PMID: 34331699
Article Published Date : Dec 31, 2020
Authors : Mohammad Bagherniya, Davood Soleimani, Mohammad Hossein Rouhani, Gholamreza Askari, Thozhukat Sathyapalan, Amirhossein Sahebkar
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetic Nephropathy : CK(1405) : AC(539), Proteinuria : CK(177) : AC(33)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

Therapeutic effect of curcumin on oral diseases.

Pubmed Data : Phytother Res. 2020 Nov 17. Epub 2020 Nov 17. PMID: 33205472
Article Published Date : Nov 16, 2020
Authors : Weilong Tang, Minquan Du, Shuang Zhang, Han Jiang
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Oral Cancer : CK(717) : AC(384), Periodontal Diseases : CK(808) : AC(203)
Pharmacological Actions : Anti-Bacterial Agents : CK(4228) : AC(1989), Anti-Inflammatory Agents : CK(39737) : AC(15858), Anticarcinogenic Agents : CK(2152) : AC(1018), Antioxidants : CK(34551) : AC(14499), Chemopreventive : CK(6580) : AC(2166)

Therapeutic effects of curcumin on sepsis and mechanisms of action.

Pubmed Data : Phytother Res. 2019 Nov ;33(11):2798-2820. Epub 2019 Aug 19. PMID: 31429161
Article Published Date : Oct 31, 2019
Authors : Arash Karimi, Ramin Ghodsi, Fateme Kooshki, Mozhdeh Karimi, Vahid Asghariazar, Ali Tarighat-Esfanjani
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Sepsis : CK(1436) : AC(491)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Phytotherapy : CK(4003) : AC(1031)

Therapeutic potential of curcumin in eye diseases.

Pubmed Data : Cent Eur J Immunol. 2019 ;44(2):181-189. Epub 2019 Jul 30. PMID: 31530988
Article Published Date : Dec 31, 2018
Authors : Dorota M Radomska-Leśniewska, Anna Osiecka-Iwan, Anna Hyc, Agata Góźdź, Anna M Dąbrowska, Piotr Skopiński
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cataract : CK(444) : AC(123), Conjunctivitis : CK(106) : AC(20), Diabetic Retinopathy : CK(483) : AC(211), Glaucoma : CK(611) : AC(145), Macular Degeneration : CK(604) : AC(173), Pterygium : CK(3) : AC(3), Uveitis : CK(156) : AC(40)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

These findings indicated that intranasal curcumin treatment effectively helped promote diabetic corneal epithelial/nerve wound healing.

Pubmed Data : Sci Rep. 2016 ;6:29753. Epub 2016 Jul 11. PMID: 27405815
Article Published Date : Dec 31, 2015
Authors : Chuanlong Guo, Mengshuang Li, Xia Qi, Guiming Lin, Fenghua Cui, Fengjie Li, Xianggen Wu
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetic Complications : CK(4678) : AC(1606), Wound Healing: Delayed : CK(132) : AC(52)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

These findings suggest a possible synergistic effect of nano-curcumin and coenzyme Q10 on clinical features of migraine.

Pubmed Data : Nutr Neurosci. 2019 Jun 26:1-10. Epub 2019 Jun 26. PMID: 31241007
Article Published Date : Jun 25, 2019
Authors : Mohammad Parohan, Payam Sarraf, Mohammad Hassan Javanbakht, Abbas Rahimi Foroushani, Sakineh Ranji-Burachaloo, Mahmoud Djalali
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10 : CK(2359) : AC(412), Curcumin : CK(7239) : AC(3319)
Diseases : Headache: Migraine : CK(1018) : AC(130)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Prophylactic Agents : CK(1700) : AC(335)
Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

These results suggest a preventive therapeutic potential for C. longa and its constituent, curcumin in asthma.

Pubmed Data : Iran J Basic Med Sci. 2017 Feb ;20(2):155-165. PMID: 28293392
Article Published Date : Jan 31, 2017
Authors : Farzaneh Shakeri, Mohammad Soukhtanloo, Mohammad Hossein Boskabady
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Asthma : CK(3242) : AC(707)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)

These results suggest that curcumin may have great therapeutic potential in the treatment of diabetic retinopathy.

Pubmed Data : Ophthalmic Res. 2018 Mar 29. Epub 2018 Mar 29. PMID: 29597206
Article Published Date : Mar 28, 2018
Authors : Fang Yang, Jinqiang Yu, Feng Ke, Mei Lan, Dekun Li, Ke Tan, Jiaojiao Ling, Ying Wang, Kaili Wu, Dai Li
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetic Retinopathy : CK(483) : AC(211)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hypoglycemic Agents : CK(9221) : AC(2076), Vascular Endothelial Growth Factor Inhibitors : CK(611) : AC(335)

This review focuses on the different targets of curcumin to treat cancer.

Pubmed Data : Asian Pac J Cancer Prev. 2016 ;17(6):2735-9. PMID: 27356682
Article Published Date : Dec 31, 2015
Authors : Muhammad Imran Qadir, Syeda Tahira Qousain Naqvi, Syed Aun Muhammad
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cancers: All : CK(36404) : AC(14363)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anticarcinogenic Agents : CK(2152) : AC(1018), Antioxidants : CK(34551) : AC(14499), Chemopreventive : CK(6580) : AC(2166)

This review highlights the current knowledge on the potential effects of the natural compound curcumin on cognition.

Pubmed Data : Nutrients. 2021 Apr 30 ;13(5). Epub 2021 Apr 30. PMID: 33946356
Article Published Date : Apr 29, 2021
Authors : Alessandra Berry, Barbara Collacchi, Roberta Masella, Rosaria Varì, Francesca Cirulli
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alzheimer's Disease : CK(5355) : AC(2210), Brain Inflammation : CK(1784) : AC(928), Cognitive Decline/Dysfunction : CK(5382) : AC(1059)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

This reviews the effects of curcumin on endometriosis and possible molecular mechanisms are discussed.

Pubmed Data : Biomed Pharmacother. 2017 Oct 25 ;97:91-97. Epub 2017 Oct 25. PMID: 29080464
Article Published Date : Oct 24, 2017
Authors : Tahereh Arablou, Roya Kolahdouz-Mohammadi
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Endometriosis : CK(579) : AC(159)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Anti-metastatic : CK(2870) : AC(2182), Antioxidants : CK(34551) : AC(14499)

This study found that melatonin and curcumin can be used to quicken neural recovery and help treat nerve injury.

Pubmed Data : EXCLI J. 2019 ;18:653-665. Epub 2019 Aug 21. PMID: 31611748
Article Published Date : Dec 31, 2018
Authors : Farshad Moharrami Kasmaie, Zohreh Jahromi, Rouhollah Gazor, Arash Zaminy
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Melatonin : CK(2891) : AC(911)
Diseases : Sciatic Nerve Crush Injury : CK(211) : AC(104)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Turmeric extract alleviates airway inflammation via oxidative stress-driven MAPKs/MMPs pathway.

Pubmed Data : Int Immunopharmacol. 2024 Nov 15 ;141:113018. Epub 2024 Aug 30. PMID: 39216235
Article Published Date : Nov 14, 2024
Authors : Jeong-Won Kim, Ji-Soo Jeong, Jin-Hwa Kim, Chang-Yeop Kim, Eun-Hye Chung, Je-Won Ko, Tae-Won Kim
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Asthma : CK(3242) : AC(707), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Using curcumin effectively prevented intestinal ischemia reperfusion injury induced lung injury.

Pubmed Data : Int J Clin Exp Pathol. 2015 ;8(4):3451-9. Epub 2015 Apr 1. PMID: 26097529
Article Published Date : Dec 31, 2014
Authors : Zhe Fan, Jihong Yao, Yang Li, Xiaowei Hu, Huizhu Shao, Xiaofeng Tian
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Intestinal Ischemia : CK(64) : AC(32)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin could effectively inhibit quinocetone induced apoptosis and inflammatory response in L02 cells.

Pubmed Data : Food Chem Toxicol. 2016 Jun 29. Epub 2016 Jun 29. PMID: 27375190
Article Published Date : Jun 28, 2016
Authors : Chongshan Dai, Bin Li, Yan Zhou, Daowen Li, Shen Zhang, Hui Li, Xilong Xiao, Shusheng Tang
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Inflammation : CK(16108) : AC(5498), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Antioxidants : CK(34551) : AC(14499), Cytoprotective : CK(809) : AC(401), NF-kappaB Inhibitor : CK(5952) : AC(3464), Nrf2 activation : CK(3156) : AC(1794)
Additional Keywords : Dose Response : CK(1770) : AC(700)

Curcumin protects against Aflatoxin B1-induced liver injury.

Pubmed Data : Ecotoxicol Environ Saf. 2021 Jan 15 ;208:111725. Epub 2020 Dec 5. PMID: 33396056
Article Published Date : Jan 14, 2021
Authors : Sihong Li, Ruimeng Liu, Gaoqiang Wei, Guifang Guo, Hongxiao Yu, Yixin Zhang, Muhammad Ishfaq, Saqib Ali Fazilani, Xiuying Zhang
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Inflammation : CK(16108) : AC(5498), Liver Damage: Aflatoxin-Induced : CK(104) : AC(48), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Effects of curcumin, a bioactive component of turmeric, on type 2 diabetes mellitus and its complications.

Pubmed Data : Food Funct. 2022 Nov 28 ;13(23):11999-12010. Epub 2022 Nov 28. PMID: 36367124
Article Published Date : Nov 27, 2022
Authors : Osman Bozkurt, Betül Kocaadam-Bozkurt, Hilal Yildiran
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetes Mellitus: Type 2 : CK(12953) : AC(2579), Inflammation : CK(16108) : AC(5498)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hypoglycemic Agents : CK(9221) : AC(2076), Hypolipidemic : CK(9173) : AC(2038)

This study demonstrated that turmeric or curcumin supplementation might have beneficial effects on some parameters related to prostate diseases.

Pubmed Data : Adv Exp Med Biol. 2021 ;1291:345-362. PMID: 34331700
Article Published Date : Dec 31, 2020
Authors : Mohammad Bagherniya, Gholamreza Askari, Babak Alikiaii, Saeed Abbasi, Davood Soleimani, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Inflammation : CK(16108) : AC(5498), Prostate Cancer : CK(2805) : AC(1046), Prostate Diseases : CK(4) : AC(3)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Chemotherapeutic : CK(4390) : AC(1635)

A combined dosage of tetrahydrocurcumin and chlorogenic acid protects against experimentally induced type 2 diabetes in rats.

Pubmed Data : Mol Cell Biochem. 2010 Aug;341(1-2):109-17. Epub 2010 Mar 26. PMID: 20339905
Article Published Date : Aug 01, 2010
Authors : Leelavinothan Pari, Krishnamoorthy Karthikesan, Venugopal P Menon
Study Type : Animal Study
Additional Links
Substances : Chlorogenic Acid : CK(431) : AC(189), Curcumin : CK(7239) : AC(3319), Tetrahydrocurcumin : CK(173) : AC(99)
Diseases : Diabetes Mellitus: Type 2 : CK(12953) : AC(2579), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Administration of curcumin and rutin could reduce the oxidative stress and enhance the antioxidant status in hyperglycemic periodontitis rats.

Pubmed Data : Molecules. 2021 Mar 2 ;26(5). Epub 2021 Mar 2. PMID: 33801378
Article Published Date : Mar 01, 2021
Authors : Gilda M Iova, Horia Calniceanu, Adelina Popa, Camelia A Szuhanek, Olivia Marcu, Gabriela Ciavoi, Ioana Scrobota
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Rutin : CK(463) : AC(223)
Diseases : Hyperglycemia : CK(2240) : AC(709), Oxidative Stress : CK(14758) : AC(5716), Periodontitis : CK(1328) : AC(311)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Antioxidant therapies for traumatic brain injury.

Pubmed Data : Neurotherapeutics. 2010 Jan;7(1):51-61. PMID: 20129497
Article Published Date : Jan 01, 2010
Authors : Edward D Hall, Radhika A Vaishnav, Ayman G Mustafa
Study Type : Review
Additional Links
Substances : Alpha-Lipoic Acid : CK(1501) : AC(366), Antioxidant formulas : CK(500) : AC(80), Curcumin : CK(7239) : AC(3319), Resveratrol : CK(3228) : AC(1513)
Diseases : Brain Injury: Traumatic : CK(383) : AC(131), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Antiviral therapies based on antioxidants are promising therapeutic agents against japanese encephalitis.

Pubmed Data : Int J Infect Dis. 2014 Jul ;24:30-6. Epub 2014 Apr 26. PMID: 24780919
Article Published Date : Jun 30, 2014
Authors : Yu Zhang, Zehua Wang, Huan Chen, Zongtao Chen, Yanping Tian
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Encephalitis: Japanese : CK(25) : AC(13), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Infective Agents : CK(92) : AC(47), Antioxidants : CK(34551) : AC(14499), Antiviral Agents : CK(3095) : AC(1702)
Additional Keywords : Antioxidants : CK(303) : AC(126), Selective Cytotoxicity : CK(274) : AC(201)

Article provides evidence that both resveratrol and curcumin possess great potential both as chemopreventive agents and anticancer drugs.

Pubmed Data : Molecules. 2010 ;15(10):7035-74. Epub 2010 Oct 12. PMID: 20944521
Article Published Date : Jan 01, 2010
Authors : Mareike Kelkel, Claus Jacob, Mario Dicato, Marc Diederich
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Resveratrol : CK(3228) : AC(1513), Stilbenes : CK(233) : AC(137)
Diseases : Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379), Cell cycle arrest : CK(2120) : AC(1715)
Anti Therapeutic Actions : Chemotherapy : CK(586) : AC(120)

Cadmium induced lipid peroxidation is abolished by curcumin treatment in the animal model.

Pubmed Data : Acta Neurol Scand Suppl. 1994;154:32-41. PMID: 15177643
Article Published Date : Jan 01, 1994
Authors : Vladislav Eybl, Dana Kotyzová, Monika Bludovská
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cadmium Poisoning : CK(439) : AC(225), Lipid Peroxidation : CK(2057) : AC(806), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Capsaicin, dihydrocapsaicin, and curcumin inhibit copper-induced oxidation of human serum lipids.

Pubmed Data : J Agric Food Chem. 2006 Aug 23;54(17):6436-9. PMID: 16910741
Article Published Date : Aug 23, 2006
Authors : Kiran D K Ahuja, Dale A Kunde, Madeleine J Ball, Dominic P Geraghty
Study Type : In Vitro Study
Additional Links
Substances : Capsaicin : CK(338) : AC(129), Curcumin : CK(7239) : AC(3319), Dihydrocapsaicin : CK(1) : AC(1)
Diseases : Cholesterol: Oxidation : CK(654) : AC(159), Copper Toxicity : CK(49) : AC(23), Lipid Peroxidation : CK(2057) : AC(806), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Consumption of curcumin may be a plausible way to prevent quinoxaline 1,4-dioxides-mediated oxidative stress and genotoxicity in human or animals.

Pubmed Data : Toxicol Mech Methods. 2015 May ;25(4):340-6. Epub 2015 May 21. PMID: 25996037
Article Published Date : Apr 30, 2015
Authors : Chongshan Dai, Shusheng Tang, Daowen Li, Kena Zhao, Xilong Xiao
Study Type : Human In Vitro
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : DNA damage : CK(2301) : AC(842), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Genoprotective : CK(522) : AC(203)
Adverse Pharmacological Actions : Genotoxic : CK(545) : AC(184)

Curcumin (in low doses) is protective against ethanol-induced liver damage.

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):47-60. Epub 2008 Aug 21. PMID: 18716759
Article Published Date : Jan 01, 2009
Authors : Asser I Ghoneim
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alcohol Toxicity : CK(1235) : AC(480), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Apoptotic : CK(9585) : AC(7379), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Less is More : CK(21) : AC(3)

Curcumin activates defensive genes and protects neurons against oxidative stress.

Pubmed Data : Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):395-403. PMID: 16677086
Article Published Date : Mar 01, 2006
Authors : Giovanni Scapagnini, Claudia Colombrita, Marialaura Amadio, Velia D'Agata, Enrico Arcelli, Maria Sapienza, Alessandro Quattrone, Vittorio Calabrese
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin activates the Nrf2 pathway and induces cellular protection against oxidative injury.

Pubmed Data : Curr Mol Med. 2019 Oct 16. Epub 2019 Oct 16. PMID: 31622191
Article Published Date : Oct 15, 2019
Authors : Milad Ashrafizadeh, Zahra Ahmadi, Reza Mohamamdinejad, Tahereh Farkhondeh, Saeed Samarghandian
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Nrf2 activation : CK(3156) : AC(1794)

Curcumin administration ameliorates oxidative stress-induced apoptosis in osteoblasts.

Pubmed Data : Cell Physiol Biochem. 2017 Feb 8 ;41(2):661-677. Epub 2017 Feb 8. PMID: 28291961
Article Published Date : Feb 07, 2017
Authors : Panpan Dai, Yixin Mao, Xiaoyu Sun, Xumin Li, Ibrahim Muhammad, Weiyan Gu, Dafeng Zhang, Yu Zhou, Jianfeng Ma, Zhenyu Ni, Shengbin Huang
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Osteoporosis : CK(2786) : AC(758), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Osteoprotective : CK(2037) : AC(685)

Curcumin alleviates aristolochic acid nephropathy based on SIRT1/Nrf2/HO-1 signaling pathway.

Pubmed Data : Toxicology. 2022 Sep ;479:153297. Epub 2022 Aug 28. PMID: 36037877
Article Published Date : Aug 31, 2022
Authors : Zhihui Liu, Bendong Shi, Yu Wang, Qingyang Xu, Hongxin Gao, Jun Ma, Xiaowen Jiang, Wenhui Yu
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Nephropathy : CK(327) : AC(86), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Antioxidants : CK(34551) : AC(14499), Heme oxygenase-1 up-regulation : CK(1336) : AC(776), Nrf2 activation : CK(3156) : AC(1794), SIRT1 Activator : CK(382) : AC(190), Superoxide Dismutase Up-regulation : CK(2383) : AC(928)

Curcumin ameliorates aflatoxin-induced lipid peroxidation in liver, kidney and testis of mice.

Pubmed Data : Acta Pol Pharm. 2007 Sep-Oct;64(5):413-6. PMID: 18540160
Article Published Date : Sep 01, 2007
Authors : Neeta Mathuria, Ramtej J Verma
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aflatoxicosis : CK(301) : AC(109), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin ameliorates oxidative stress during nicotine-induced lung toxicity in rats.

Pubmed Data : Ital J Biochem. 2004 Jul;53(2):82-6. PMID: 15646012
Article Published Date : Jul 01, 2004
Authors : Chandran Kalpana, Venugopal Padmanabhan Menon
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Nicotine/Tobacco Toxicity : CK(273) : AC(108), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin ameliorates sodium arsenite-induced oxidative damage and lipid peroxidation in different rat organs.

Pubmed Data : Molecules. 2009;14(3):1098-110. Epub 2009 Mar 10. PMID: 19049818
Article Published Date : Jan 01, 2009
Authors : Fatma M El-Demerdash, Mokhtar I Yousef, Fatma M E Radwan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Arsenic Poisoning : CK(383) : AC(129), Lipid Peroxidation : CK(2057) : AC(806), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin and ascorbic acid exhibit antioxidant and anticarcinogenic properties.

Pubmed Data : Cancer Lett. 1992 Apr 30;63(3):237-41. PMID: 1576592
Article Published Date : Apr 30, 1992
Authors : S C Sahu, M C Washington
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Vitamin C : CK(6066) : AC(1408)
Diseases : Cancers: All : CK(36404) : AC(14363), DNA damage : CK(2301) : AC(842), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Chemopreventive : CK(6580) : AC(2166)

Curcumin and Boswellia serrate has beneficial effects on glycoxidation and lipid peroxidation in chronically exercising master athletes.

Pubmed Data : Nutrients. 2016 Nov 21 ;8(11). Epub 2016 Nov 21. PMID: 27879642
Article Published Date : Nov 20, 2016
Authors : Nino Cristiano Chilelli, Eugenio Ragazzi, Romina Valentini, Chiara Cosma, Stefania Ferraresso, Annunziata Lapolla, Giovanni Sartore
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Frankincense : CK(1021) : AC(260)
Diseases : Advanced Glycation End products (AGE) : CK(589) : AC(249), Lipid Peroxidation : CK(2057) : AC(806), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Phytotherapy : CK(4003) : AC(1031), Plant Extracts : CK(18762) : AC(6782)

Curcumin and capsaicin have hypolipidemic and antioxidant effects in high-fat-fed rats.

Pubmed Data : Can J Physiol Pharmacol. 2007 Jun;85(6):588-96. PMID: 17823620
Article Published Date : Jun 01, 2007
Authors : H Manjunatha, K Srinivasan
Study Type : Animal Study
Additional Links
Substances : Capsaicin : CK(338) : AC(129), Curcumin : CK(7239) : AC(3319)
Diseases : Hyperlipidemia : CK(2140) : AC(553), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hypolipidemic : CK(9173) : AC(2038)

Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice.

Pubmed Data : J Nutr. 2001 Aug;131(8):2090-5. PMID: 11481399
Article Published Date : Aug 01, 2001
Authors : K Okada, C Wangpoengtrakul, T Tanaka, S Toyokuni, K Uchida, T Osawa
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Tetrahydrocurcumin : CK(173) : AC(99)
Diseases : Kidney Damage : CK(805) : AC(359), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anticarcinogenic Agents : CK(2152) : AC(1018), Antioxidants : CK(34551) : AC(14499), Renoprotective : CK(4544) : AC(1971)

Curcumin and piperine prevents chemically-induced oral cancer.

Pubmed Data : Singapore Med J. 2009 Feb;50(2):139-46. PMID: 19296028
Article Published Date : Feb 01, 2009
Authors : S Manoharan, S Balakrishnan, V P Menon, L M Alias, A R Reena
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Piperidines : CK(99) : AC(31)
Diseases : Oral Cancer : CK(717) : AC(384), Oxidative Stress : CK(14758) : AC(5716), Squamous cell carcinoma : CK(676) : AC(348)
Pharmacological Actions : Anticarcinogenic Agents : CK(2152) : AC(1018), Antioxidants : CK(34551) : AC(14499)

Curcumin and tetrahydrocurcumin can alleviate vascular dysfunction and high blood pressure caused by cadmium toxicity.

Pubmed Data : Tohoku J Exp Med. 2016 ;239(1):25-38. PMID: 27151191
Article Published Date : Dec 31, 2015
Authors : Upa Kukongviriyapan, Kwanjit Apaijit, Veerapol Kukongviriyapan
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Tetrahydrocurcumin : CK(173) : AC(99)
Diseases : Cadmium Poisoning : CK(439) : AC(225), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antihypertensive Agents : CK(7081) : AC(1029), Antioxidants : CK(34551) : AC(14499)
Problem Substances : Cadmium : CK(600) : AC(268)

Curcumin and turmeric inhibit adverse consequences of lipid peroxidation.

Pubmed Data : J Ethnopharmacol. 2007 Mar 21;110(2):368-73. Epub 2006 Oct 13. PMID: 17116380
Article Published Date : Mar 21, 2007
Authors : Biji T Kurien, R Hal Scofield
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Lipid Peroxidation : CK(2057) : AC(806), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin and vitamin E were shown to protect rat lungs from oxidative damage.

Pubmed Data : Hum Exp Toxicol. 2014 Sep 17. Epub 2014 Sep 17. PMID: 25233897
Article Published Date : Sep 16, 2014
Authors : S Hassani, Mr Sepand, A Jafari, J Jaafari, R Rezaee, M Zeinali, F Tavakoli, K Razavi-Azarkhiavi
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Vitamin E : CK(3040) : AC(571)
Diseases : Lipid Peroxidation : CK(2057) : AC(806), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Superoxide Dismutase Up-regulation : CK(2383) : AC(928)

Curcumin attenuated glutamate neurotoxicity by inhibiting ER stress-associated TXNIP/NLRP3 inflammasome activation.

Pubmed Data : Toxicol Appl Pharmacol. 2015 Jul 1 ;286(1):53-63. Epub 2015 Mar 16. PMID: 25791922
Article Published Date : Jun 30, 2015
Authors : Ying Li, Jia Li, Shanshan Li, Yi Li, Xiangxiang Wang, Baolin Liu, Qiang Fu, Shiping Ma
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin attenuated hypertension-induced oxidative stress and vascular structural modifications.

Pubmed Data : Nitric Oxide. 2014 Nov 15 ;42:44-53. Epub 2014 Sep 4. PMID: 25194767
Article Published Date : Nov 14, 2014
Authors : Orachorn Boonla, Upa Kukongviriyapan, Poungrat Pakdeechote, Veerapol Kukongviriyapan, Patchareewan Pannangpetch, Parichat Prachaney, Stephen E Greenwald
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Endothelial Dysfunction : CK(2733) : AC(581), Hypertension : CK(9125) : AC(1361), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antihypertensive Agents : CK(7081) : AC(1029), Antioxidants : CK(34551) : AC(14499), Nitric Oxide Enhancer : CK(324) : AC(90), Vasodilator Agents : CK(892) : AC(233)

Curcumin attenuated neurodegeneration in this animal model Alzheimer's disease.

Pubmed Data : J Alzheimers Dis. 2016 Apr 5. Epub 2016 Apr 5. PMID: 27060945
Article Published Date : Apr 04, 2016
Authors : Han-Chang Huang, Bo-Wen Zheng, Yu Guo, Jian Zhao, Jiang-Yan Zhao, Xiao-Wei Ma, Zhao-Feng Jiang
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alzheimer's Disease : CK(5355) : AC(2210), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin attenuates alcohol toxicity.

Pubmed Data : J Pharm Pharm Sci. 2004 Aug 20;7(2):274-83. Epub 2004 Aug 20. PMID: 15367386
Article Published Date : Aug 20, 2004
Authors : Rajagopalan Rukkumani, Kode Aruna, Penumathsa Suresh Varma, Kallikat Narayanan Rajasekaran, Venugopal Padmanabhan Menon
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alcohol Toxicity : CK(1235) : AC(480), Chemically-Induced Liver Damage : CK(2304) : AC(1089), Lipid Peroxidation : CK(2057) : AC(806), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin attenuates cadmium-induced tisse damage in mice.

Pubmed Data : J Appl Toxicol. 2006 May-Jun;26(3):207-12. PMID: 16345010
Article Published Date : May 01, 2006
Authors : Vladislav Eybl, Dana Kotyzová, Ladislav Lesetický, Monika Bludovská, Jaroslav Koutenský
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cadmium Poisoning : CK(439) : AC(225), Lipid Peroxidation : CK(2057) : AC(806), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction.

Pubmed Data : Arch Toxicol. 2008 Jul;82(7):471-81. Epub 2007 Nov 30. PMID: 18060385
Article Published Date : Jul 01, 2008
Authors : Nageswaran Sivalingam, Jayasree Basivireddy, Kunissery A Balasubramanian, Molly Jacob
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Drug-Induced Toxicity: Indomethacin : CK(78) : AC(40), Mitochondrial Diseases : CK(624) : AC(269), Mitochondrial Dysfunction : CK(628) : AC(269), NSAID-induced toxicity : CK(1142) : AC(429), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Drug: Indomethacin : CK(67) : AC(33)

Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats.

Pubmed Data : J Egypt Natl Canc Inst. 2008 Jun;20(2):141-8. PMID: 20029470
Article Published Date : Jun 01, 2008
Authors : Ramadan A M Hemeida, Omar M Mohafez
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Drug Toxicity: Methotrexate : CK(194) : AC(100), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin attenuates oxidative damage in animals treated with a renal carcinogen, ferric nitrilotriacetate (Fe-NTA).

Pubmed Data : Mol Cell Biochem. 2009 Apr;324(1-2):157-64. Epub 2009 Jan 23. PMID: 19165575
Article Published Date : Apr 01, 2009
Authors : Mohammad Iqbal, Yasumasa Okazaki, Shigeru Okada
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemical Exposure : CK(112) : AC(40), Kidney Damage : CK(805) : AC(359), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Chemopreventive : CK(6580) : AC(2166), Renoprotective : CK(4544) : AC(1971)

Curcumin attenuates oxidative stress in RAW264.7 cells by increasing the activity of antioxidant enzymes and activating the Nrf2-Keap1 pathway.

Pubmed Data : PLoS One. 2019 ;14(5):e0216711. Epub 2019 May 21. PMID: 31112588
Article Published Date : Dec 31, 2018
Authors : Xinyu Lin, Dingping Bai, Zixi Wei, Ying Zhang, Yifan Huang, Hui Deng, Xiaohong Huang
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Heme oxygenase-1 up-regulation : CK(1336) : AC(776), Immunomodulatory : CK(6531) : AC(2360), Nrf2 activation : CK(3156) : AC(1794), Superoxide Dismutase Up-regulation : CK(2383) : AC(928)

Curcumin attenuates the kainic acid-induced hippocampal cell death in the mice.

Pubmed Data : Carcinogenesis. 2009 Nov;30(11):1949-56. Epub 2009 Sep 30. PMID: 17300872
Article Published Date : Nov 01, 2009
Authors : Hyun Joo Shin, Ji Yeong Lee, Eunyung Son, Dong Hun Lee, Hyun Joon Kim, Sang Soo Kang, Gyeong Jae Cho, Wan Sung Choi, Gu Seob Roh
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Brain Injury: Hippocampal Damage : CK(44) : AC(21), Neurodegenerative Diseases : CK(13103) : AC(4279), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Enzyme Inhibitors : CK(846) : AC(399), Excitatory Amino Acid Agonists : CK(9) : AC(5), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin co-treatment seems to prevent oxidative damage and found to delay the development of cataract.

Pubmed Data : Indian J Exp Biol. 2004 Jun;42(6):601-3. PMID: 15260112
Article Published Date : Jun 01, 2004
Authors : S Padmaja, T N Raju
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cataract : CK(444) : AC(123), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Enzyme Inhibitors : CK(846) : AC(399)

Curcumin could attenuate cadmium quantum dots induced oxidative stress and lethality.

Pubmed Data : Environ Toxicol Pharmacol. 2016 Jan 4 ;42:55-62. Epub 2016 Jan 4. PMID: 26773363
Article Published Date : Jan 03, 2016
Authors : Swati Srivastava, Aakanksha Pant, Shalini Trivedi, Rakesh Pandey
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cadmium Poisoning : CK(439) : AC(225), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin could partially protect against reoxygenation injury in animals.

Pubmed Data : Adv Pharmacol Sci. 2016;2016:6173648. Epub 2016 Jan 21. PMID: 26904113
Article Published Date : Dec 31, 2015
Authors : Ermita I Ibrahim Ilyas, Busjra M Nur, Sonny P Laksono, Anton Bahtiar, Ari Estuningtyas, Caecilia Vitasyana, Dede Kusmana, Frans D Suyatna, Muhammad Kamil Tadjudin, Hans-Joachim Freisleben
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Myocardial Ischemia : CK(1001) : AC(460), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963)

Curcumin counteracts the aluminium-induced ageing-related alterations in the rat brain.

Pubmed Data : Biogerontology. 2009 Aug;10(4):489-502. Epub 2008 Nov 20. PMID: 19020987
Article Published Date : Aug 01, 2009
Authors : Deepak Sharma, Pallavi Sethi, Ezaj Hussain, Rameshwar Singh
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aging : CK(6221) : AC(1510), Aging: Brain : CK(1118) : AC(268), Aluminum Toxicity : CK(735) : AC(318), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin enhanced therapeutic efficacy of M. oleifera root extract and showed better antioxidant potential against beryllium toxicity.

Pubmed Data : Pharm Biol. 2015 Oct ;53(10):1465-73. Epub 2015 Apr 8. PMID: 25853973
Article Published Date : Sep 30, 2015
Authors : Narottam Das Agrawal, Satendra Kumar Nirala, Sangeeta Shukla, Ramesh Mathur
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Moringa oleifera : CK(748) : AC(377)
Diseases : Beryllium-induced Toxicity : CK(4) : AC(2), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Renoprotective : CK(4544) : AC(1971)

Curcumin has a beneficial therapeutic effect in diabetes-induced heart failure.

Pubmed Data : J Biochem Mol Toxicol. 2014 Jun ;28(6):263-70. Epub 2014 Apr 24. PMID: 24760747
Article Published Date : May 31, 2014
Authors : Osama M Abo-Salem, Gamaleldin I Harisa, Tarek M Ali, El-Sayed M El-Sayed, Fatma M Abou-Elnour
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetic Complications : CK(4678) : AC(1606), Heart Failure : CK(1929) : AC(337), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Interleukin-6 Downregulation : CK(9337) : AC(3613), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin has a cytoprotective and immunomodulating effect in rats subjected to carbon tetrachloride-induced oxidative stress.

Pubmed Data : Br J Rheumatol. 1994 Sep;33(9):847-52. PMID: 18340409
Article Published Date : Sep 01, 1994
Authors : H A Abu-Rizq, M H Mansour, A M Safer, M Afzal
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemical Exposure : CK(112) : AC(40), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Cytoprotective : CK(809) : AC(401)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Curcumin has a neuroprotective effect against homocysteine-induced cognitive impairment and oxidative stress in the rat.

Pubmed Data : Pharmacol Biochem Behav. 2010 Oct;96(4):378-85. Epub 2010 Jul 6. PMID: 20619287
Article Published Date : Oct 01, 2010
Authors : Amin Ataie, Masoumeh Sabetkasaei, Abbas Haghparast, Akbar Hajizadeh Moghaddam, Behrang Kazeminejad
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cognitive Decline/Dysfunction : CK(5382) : AC(1059), Homocysteine: Elevated : CK(780) : AC(113), Neurodegenerative Diseases : CK(13103) : AC(4279), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin has a protective effect against oxidative damage on skin cells.

Pubmed Data : J Trauma. 2001 Nov;51(5):927-31. PMID: 11706342
Article Published Date : Nov 01, 2001
Authors : T T Phan, P See, S T Lee, S Y Chan
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Infective Agents: Urinary : CK(3) : AC(2), Antioxidants : CK(34551) : AC(14499), Enzyme Inhibitors : CK(846) : AC(399)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Curcumin has a protective effect on eccentric exercise induced muscle damage.

Pubmed Data : Int J Vitam Nutr Res. 2014 ;84(3-4):163-72. PMID: 26098480
Article Published Date : Dec 31, 2013
Authors : Ismail Boz, Muaz Belviranli, Nilsel Okudan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Muscle Damage: Exercise-Induced : CK(1101) : AC(137), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Malondialdehyde Down-regulation : CK(3028) : AC(992)

Curcumin has anti-ulcer activity in experimental gastric ulcer in rats.

Pubmed Data : Biomed Environ Sci. 2009 Dec;22(6):488-95. PMID: 20337222
Article Published Date : Dec 01, 2009
Authors : M Tuorkey, K Karolin
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Gastric Ulcer : CK(631) : AC(291), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Ulcer Agents : CK(1250) : AC(341), Antioxidants : CK(34551) : AC(14499), Gastroprotective : CK(1692) : AC(701), Interleukin-6 Downregulation : CK(9337) : AC(3613)

Curcumin has antioxidant activity.

Pubmed Data : Mutat Res. 1994 Dec 1;311(2):249-55. PMID: 7526190
Article Published Date : Dec 01, 1994
Authors : M Subramanian, Sreejayan, M N Rao, T P Devasagayam, B B Singh
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : DNA damage : CK(2301) : AC(842), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antimutagenic Agents : CK(218) : AC(138), Antioxidants : CK(34551) : AC(14499)

Curcumin has neuroprotective effects against a fungal toxin.

Pubmed Data : Methods Find Exp Clin Pharmacol. 2007 Jan-Feb;29(1):19-25. PMID: 17344940
Article Published Date : Jan 01, 2007
Authors : P Kumar, S S V Padi, P S Naidu, A Kumar
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Fungal Infection : CK(511) : AC(285), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Curcumin improves D-galactose and normal-aging associated memory impairment.

Pubmed Data : PLoS One. 2022 ;17(6):e0270123. Epub 2022 Jun 29. PMID: 35767571
Article Published Date : Dec 31, 2021
Authors : Md Ashrafur Rahman, Arif Anzum Shuvo, Asim Kumar Bepari, Mehedi Hasan Apu, Manik Chandra Shill, Murad Hossain, Mohammed Uddin, Md Rabiul Islam, Monjurul Kader Bakshi, Javed Hasan, Atiqur Rahman, Ghazi Mohammad Sayedur Rahman, Hasan Mahmud Reza
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aging : CK(6221) : AC(1510), Memory Disorders : CK(2227) : AC(614), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin improves outcomes and attenuates focal cerebral ischemic injury.

Pubmed Data : Neurochem Res. 2010 Mar;35(3):374-9. Epub 2009 Sep 23. PMID: 19774461
Article Published Date : Mar 01, 2010
Authors : Jing Zhao, Shanshan Yu, Weiping Zheng, Gang Feng, Guobiao Luo, Linli Wang, Yong Zhao
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cerebral Ischemia : CK(1183) : AC(566), Middle Cerebral Artery Occlusion (MCAO) : CK(121) : AC(53), Oxidative Stress : CK(14758) : AC(5716), Stroke: Recovery : CK(70) : AC(11)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin inhibits glutamate-induced excitoxicity in vitro.

Pubmed Data : Mol Cell Biochem. 2007 Apr;298(1-2):187-94. Epub 2006 Nov 25. PMID: 17131042
Article Published Date : Apr 01, 2007
Authors : Hyun-Woo Suh, Seongman Kang, Ki-Sun Kwon
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Excitotoxicity : CK(59) : AC(36), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin inhibits lipid peroxidation and protein oxidation in rat liver mitochondria.

Pubmed Data : Biochim Biophys Acta. 2006 Jan;1760(1):70-7. Epub 2005 Oct 3. PMID: 16236451
Article Published Date : Jan 01, 2006
Authors : Qing-Yi Wei, Wei-Feng Chen, Bo Zhou, Li Yang, Zhong-Li Liu
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Lipid Peroxidation : CK(2057) : AC(806), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin inhibits nicotine-induced toxicity.

Pubmed Data : J Med Food. 2004;7(4):467-71. PMID: 15671691
Article Published Date : Jan 01, 2004
Authors : C Kalpana, Venugopal P Menon
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Nicotine/Tobacco Toxicity : CK(273) : AC(108), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin inhibits reactive oxygen species formation and vascular hyperpermeability following haemorrhagic shock.

Pubmed Data : Clin Exp Pharmacol Physiol. 2010 Sep;37(9):939-44. Epub 2010 May 28. PMID: 20528978
Article Published Date : Sep 01, 2010
Authors : Binu Tharakan, Felicia A Hunter, W Roy Smythe, Ed W Childs
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Hemorrhagic Shock : CK(45) : AC(22), Oxidative Stress : CK(14758) : AC(5716), Vascular Diseases: Hyperpermeability : CK(2) : AC(1)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin may attenuate lead and cadmium-induce neurotoxicity.

Pubmed Data : Anesth Analg. 2001 Oct;93(4):912-6. PMID: 14729307
Article Published Date : Oct 01, 2001
Authors : Sheril Daniel, Janice L Limson, Amichand Dairam, Gareth M Watkins, Santy Daya
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Brain Injury: Hippocampal Damage : CK(44) : AC(21), Cadmium Poisoning : CK(439) : AC(225), Lead Poisoning : CK(483) : AC(182), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

curcumin may be an effective strategy to combat the genotoxicity of arsenic.

Pubmed Data : Asian Pac J Cancer Prev. 2010;11(1):239-47. PMID: 20593964
Article Published Date : Jan 01, 2010
Authors : Jaydip Biswas, Soumi Roy, Sutapa Mukherjee, Dona Sinha, Madhumita Roy
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Arsenic Poisoning : CK(383) : AC(129), DNA damage : CK(2301) : AC(842), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin may be effective in the management of diet-induced oxidative stress.

Pubmed Data : Sci Pharm. 2015 ;83(1):159-75. Epub 2014 Nov 4. PMID: 26839808
Article Published Date : Dec 31, 2014
Authors : Nachimuthu Maithili Karpaga Selvi, Magadi Gopalakrishna Sridhar, Rathinam Palamalai Swaminathan, Ramalingam Sripradha
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : High Fat Diet : CK(2040) : AC(984), High Fructose Diet : CK(474) : AC(187), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Malondialdehyde Down-regulation : CK(3028) : AC(992), Renoprotective : CK(4544) : AC(1971)

Curcumin may be useful to ameliorate lipid metabolism alterations and oxidative damage associated with hormone deprivation in menopause.

Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:5719291. Epub 2015 Nov 23. PMID: 26640615
Article Published Date : Dec 31, 2015
Authors : Maurilio da Silva Morrone, Carlos Eduardo Schnorr, Guilherme Antônio Behr, Juciano Gasparotto, Rafael Calixto Bortolin, Katia da Boit Martinello, Bernardo Saldanha Henkin, Thallita Kelly Rabello, Alfeu Zanotto-Filho, Daniel Pens Gelain, José Cláudio Fonseca Moreira
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Menopausal Syndrome : CK(768) : AC(114), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hypolipidemic : CK(9173) : AC(2038)

Curcumin may inhibit oxidative stress including LDL cholesterol oxidation.

Pubmed Data : J Enzyme Inhib Med Chem. 2010 Oct;25(5):720-9. PMID: 20163327
Article Published Date : Oct 01, 2010
Authors : Hye-Sook Lee, Min-Ja Lee, Hyuck Kim, Sung-Kyu Choi, Jai-Eun Kim, Hyung-In Moon, Won-Hwan Park
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cholesterol: Oxidation : CK(654) : AC(159), Endothelial Dysfunction : CK(2733) : AC(581), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), NF-kappaB Inhibitor : CK(5952) : AC(3464), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Curcumin may prevent oxidative insults to spermatozoa and thus preserve the functional activity of male gametes.

Pubmed Data : Anim Reprod Sci. 2016 Jun 21. Epub 2016 Jun 21. PMID: 27377223
Article Published Date : Jun 20, 2016
Authors : Eva Tvrdá, Eva Tušimová, Anton Kováčik, Dušan Paál, Hana Greifová, Abzal Abdramanov, Norbert Lukáč
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Oxidative Stress : CK(14758) : AC(5716), Sperm Quality: Low : CK(688) : AC(136)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Cytoprotective : CK(809) : AC(401)

Curcumin may protect rat HSCs against oxidative stress and inhibit the GO induced activation and secretion of ECM molecules in vitro.

Pubmed Data : Mol Med Rep. 2015 Dec 17. Epub 2015 Dec 17. PMID: 26676408
Article Published Date : Dec 16, 2015
Authors : Zhenxiong Liu, Weijia Dou, Yuanyuan Zheng, Qinsheng Wen, Ming Qin, Xuxia Wang, Hua Tang, Rong Zhang, Dandan Lv, Jingjie Wang, Shuguang Zhao
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Malondialdehyde Down-regulation : CK(3028) : AC(992), Nrf2 activation : CK(3156) : AC(1794)

Curcumin may protect the aging brain from oxidative stress.

Pubmed Data : Int J Dev Neurosci. 2010 Aug;28(5):351-7. Epub 2010 Apr 18. PMID: 20403421
Article Published Date : Aug 01, 2010
Authors : Preeticia Dkhar, Ramesh Sharma
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aging : CK(6221) : AC(1510), Aging: Brain : CK(1118) : AC(268), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)
Additional Keywords : Drug Synergy : CK(389) : AC(174)

Curcumin mitigates sodium fluoride toxicity in Caenorhabditis elegans.

Pubmed Data : Ecotoxicol Environ Saf. 2024 Dec ;288:117372. Epub 2024 Nov 26. PMID: 39603217
Article Published Date : Nov 30, 2024
Authors : Jianing Xu, Boning Zhang, Xiaoyu Liu, Pengyun Du, Wei Wang, Chenggang Zhang
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)
Problem Substances : Sodium Fluoride : CK(1466) : AC(405)

Curcumin pretreatment is a promising adjuvant strategy for stem cells transplantation in myocardial restoration.

Pubmed Data : Stem Cells Int. 2015 ;2015:638153. Epub 2015 May 5. PMID: 26074974
Article Published Date : Dec 31, 2014
Authors : Jianfeng Liu, Ping Zhu, Peng Song, Weiping Xiong, Haixu Chen, Wenhui Peng, Shuxia Wang, Shan Li, Zhiqing Fu, Yutang Wang, Haibin Wang
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Ischemia: Myocardial : CK(85) : AC(30), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Angiogenesis Inducing Agents : CK(290) : AC(149), Anti-Apoptotic : CK(5568) : AC(3160), Antioxidants : CK(34551) : AC(14499), Heme oxygenase-1 up-regulation : CK(1336) : AC(776)
Additional Keywords : Mesenchymal Stem Cells : CK(167) : AC(103)

Curcumin pretreatment protects against acute acrylonitrile-induced oxidative damage in rats.

Pubmed Data : Radiat Oncol. 2010 Nov 22;5(1):111. Epub 2010 Nov 22. PMID: 19913070
Article Published Date : Nov 22, 2010
Authors : Xing Guangwei, Lu Rongzhu, Xu Wenrong, Wang Suhua, Zhao Xiaowu, Wang Shizhong, Zhang Ye, Michael Aschner, Shrinivas K Kulkarni, Mahendra Bishnoi
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemical Exposure: Acrylonitrile : CK(4) : AC(2), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin prevents advanced glycation induced complications of diabetes.

Pubmed Data : Biochem Pharmacol. 1998 Dec 15;56(12):1607-14. PMID: 9973181
Article Published Date : Dec 15, 1998
Authors : G B Sajithlal, P Chithra, G Chandrakasan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : A1C : CK(277) : AC(35), Advanced Glycation End products (AGE) : CK(589) : AC(249), Diabetic Complications : CK(4678) : AC(1606), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin prevents and reverses cirrhosis induced by bile duct obstruction.

Pubmed Data : Fundam Clin Pharmacol. 2008 Aug;22(4):417-27. PMID: 18705752
Article Published Date : Aug 01, 2008
Authors : Karina Reyes-Gordillo, José Segovia, Mineko Shibayama, Victor Tsutsumi, Paula Vergara, Mario G Moreno, Pablo Muriel
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Biliary Cirrhosis : CK(12) : AC(2), Cirrhosis : CK(826) : AC(225), Gallbladder Inflammation : CK(25) : AC(5), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin prevents forebrain ischemia-induced neuronal damage and oxidative insult in the rat hippocampus.

Pubmed Data : Neurochem Res. 2006 May;31(5):611-8. Epub 2006 May 23. PMID: 16770732
Article Published Date : May 01, 2006
Authors : Fadhel A Al-Omar, Mahmoud N Nagi, Mustafa M Abdulgadir, Khalda S Al Joni, Abdulhakeem A Al-Majed
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Brain Injury: Hippocampal Damage : CK(44) : AC(21), Brain Ischemia : CK(582) : AC(255), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Apoptotic : CK(9585) : AC(7379), Enzyme Inhibitors : CK(846) : AC(399), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin prevents free radical-mediated cataractogenesis.

Pubmed Data : Free Radic Biol Med. 2010 Feb 15;48(4):483-92. Epub 2009 Dec 10. PMID: 19932168
Article Published Date : Feb 15, 2010
Authors : Ramar Manikandan, Raman Thiagarajan, Sivagnanam Beulaja, Ganapasam Sudhandiran, Munuswamy Arumugam
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cataract : CK(444) : AC(123), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin prevents selenite-induced cataractogenesis in rat pups.

Pubmed Data : Curr Eye Res. 2010 Feb;35(2):122-9. PMID: 20136422
Article Published Date : Feb 01, 2010
Authors : R Manikandan, R Thiagarajan, S Beulaja, G Sudhandiran, M Arumugam
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Vitamin C : CK(6066) : AC(1408), Vitamin E : CK(3040) : AC(571)
Diseases : Cataract : CK(444) : AC(123), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Sodium Selenite : CK(50) : AC(20)

Curcumin protects 6-hydroxydopamine (6-OHDA)-induced neuronal death associated with Parkinson disease.

Pubmed Data : Biochem Pharmacol. 2009 Jul 15;78(2):178-83. Epub 2009 Apr 8. PMID: 19464433
Article Published Date : Jul 15, 2009
Authors : Jun Wang, Xi-Xun Du, Hong Jiang, Jun-Xia Xie
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Oxidative Stress : CK(14758) : AC(5716), Parkinson's Disease : CK(3012) : AC(1116)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Apoptotic : CK(9585) : AC(7379), Neuroprotective Agents : CK(20061) : AC(7949), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin protects against acute liver damage in the rat.

Pubmed Data : Biochim Biophys Acta. 2007 Jun;1770(6):989-96. Epub 2007 Feb 22. PMID: 17383825
Article Published Date : Jun 01, 2007
Authors : Karina Reyes-Gordillo, José Segovia, Mineko Shibayama, Paula Vergara, Mario G Moreno, Pablo Muriel
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin protects against aging-related stress and dysfunction through autophagy activation in rat brain.

Pubmed Data : Mol Biol Rep. 2024 May 25 ;51(1):694. Epub 2024 May 25. PMID: 38796662
Article Published Date : May 24, 2024
Authors : Akanksha Singh, Arun Kumar Yadawa, Syed Ibrahim Rizvi
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aging: Brain : CK(1118) : AC(268), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin protects against alcohol and PUFA-induced lipid peroxidation.

Pubmed Data : Phytother Res. 2003 Sep;17(8):925-9. PMID: 13680826
Article Published Date : Sep 01, 2003
Authors : R Rukkumani, M Sri Balasubashini, Venugopal P Menon
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alcohol Toxicity : CK(1235) : AC(480), Hyperlipidemia : CK(2140) : AC(553), Lipid Peroxidation : CK(2057) : AC(806), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin protects against chemically-induced cataract formation in rat lenses.

Pubmed Data : Am J Clin Nutr. 1996 Nov;64(5):761-6. PMID: 8901798
Article Published Date : Nov 01, 1996
Authors : S Awasthi, S K Srivatava, J T Piper, S S Singhal, M Chaubey, Y C Awasthi
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cataract : CK(444) : AC(123), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin protects against chemically-induced oxidative stress in the brain.

Pubmed Data : Eur Rev Med Pharmacol Sci. 2006 Jul-Aug;10(4):157-61. PMID: 16910344
Article Published Date : Jul 01, 2006
Authors : A Rajeswari
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin protects against cisplatin-induced oxidative injury in rat testis.

Pubmed Data : Hum Reprod. 2009 Jul;24(7):1717-25. Epub 2009 Mar 11. PMID: 19279034
Article Published Date : Jul 01, 2009
Authors : Yusuf Ozlem Ilbey, Emin Ozbek, Mustafa Cekmen, Abdulmuttalip Simsek, Alper Otunctemur, Adnan Somay
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemotherapy-Induced Toxicity : CK(3239) : AC(1520), Chemotherapy-Induced Toxicity: Cisplatin : CK(1246) : AC(601), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), NF-kappaB Inhibitor : CK(5952) : AC(3464)
Additional Keywords : Drug: Cisplatin : CK(49) : AC(18)

Curcumin protects against hydrogen peroxide induced cytotoxicity.

Pubmed Data : Hum Exp Toxicol. 2010 May 20. Epub 2010 May 20. PMID: 20488840
Article Published Date : May 20, 2010
Authors : M A Siddiqui, M P Kashyap, V Kumar, V K Tripathi, V K Khanna, S Yadav, A B Pant
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Cytoprotective : CK(809) : AC(401)

Curcumin protects against methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells.

Pubmed Data : Acta Pharmacol Sin. 2006 Sep;27(9):1192-8. PMID: 16923340
Article Published Date : Sep 01, 2006
Authors : Wen-hsiung Chan, Hsin-jung Wu
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : DNA damage : CK(2301) : AC(842), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Apoptotic : CK(9585) : AC(7379)

Curcumin protects against nicotine-induced lung toxicity by modulating the extent of lipid peroxidation and augmenting antioxidant defense system.

Pubmed Data : Pol J Pharmacol. 2004 Sep-Oct;56(5):581-6. PMID: 15591646
Article Published Date : Sep 01, 2004
Authors : C Kalpana, V P Menon
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Lipid Peroxidation : CK(2057) : AC(806), Nicotine/Tobacco Toxicity : CK(273) : AC(108), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin protects against oxidative insult induced by pentylenetetrazol in epileptic rats.

Pubmed Data : Methods Find Exp Clin Pharmacol. 2010 May;32(4):227-32. PMID: 20508869
Article Published Date : May 01, 2010
Authors : V Sharma, B Nehru, A Munshi, A Jyothy
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Piperidines : CK(99) : AC(31)
Diseases : Drug-Induced Toxicity: Epilepsy Drugs : CK(19) : AC(10), Epilepsy : CK(1199) : AC(327), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)
Additional Keywords : Drug Synergy : CK(389) : AC(174)

Curcumin protects human trophoblast HTR8/SVneo cells from H2O2-induced oxidative stress.

Pubmed Data : Antioxidants (Basel). 2020 Feb 1 ;9(2). Epub 2020 Feb 1. PMID: 32024207
Article Published Date : Jan 31, 2020
Authors : Lina Qi, Jingle Jiang, Jingfei Zhang, Lili Zhang, Tian Wang
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Hydrogen Peroxide Induced Toxicity : CK(437) : AC(349), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin reduces indomethacin-induced damage in the rat small intestine.

Pubmed Data : Cancer Res. 2010 Nov 15;70(22):9218-23. Epub 2010 Oct 26. PMID: 17351913
Article Published Date : Nov 15, 2010
Authors : Nageswaran Sivalingam, Raghunath Hanumantharaya, Minnie Faith, Jayasree Basivireddy, K A Balasubramanian, Molly Jacob
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Duodenal Ulcer : CK(95) : AC(29), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Ulcer Agents : CK(1250) : AC(341), Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Drug: Indomethacin : CK(67) : AC(33)

curcumin reduces markers of liver damage in rats treated with heated sunflower oil or ethanol.

Pubmed Data : Vet Ital. 2010 Jan-Mar;46(1):83-92. PMID: 20391370
Article Published Date : Jan 01, 2010
Authors : Nasr A M N El-Deen, Mohamed Eid
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alcohol Toxicity : CK(1235) : AC(480), Liver Damage: Drug-Induced : CK(651) : AC(285), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin showed significant amelioration in all genotoxic and oxidative stress-related indices.

Pubmed Data : Drug Chem Toxicol. 2017 Feb 1:1-8. Epub 2017 Feb 1. PMID: 28147706
Article Published Date : Jan 31, 2017
Authors : Ankit Nariya, Ambar Pathan, Naumita Shah, Shiva Chettiar, Alpesh Patel, Jignasha Dattani, Divya Chandel, Mandava Rao, Devendrasinh Jhala
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Lead Poisoning : CK(483) : AC(182), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Genoprotective : CK(522) : AC(203)
Problem Substances : Lead : CK(700) : AC(231)

Curcumin significantly reduces lipid peroxidation associated with diabetes.

Pubmed Data : J Cardiovasc Pharmacol. 2005 Nov;46(5):697-705. PMID: 16220078
Article Published Date : Nov 01, 2005
Authors : Jayesh B Majithiya, R Balaraman
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetes: Cardiovascular Illness : CK(744) : AC(133), Lipid Peroxidation : CK(2057) : AC(806), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin supplementation can attenuate exercise-induced oxidative stress by increasing blood antioxidant capacity.

Pubmed Data : Int J Sports Med. 2014 Jun ;35(6):469-75. Epub 2013 Oct 28. PMID: 24165958
Article Published Date : May 31, 2014
Authors : M Takahashi, K Suzuki, H K Kim, Y Otsuka, A Imaizumi, M Miyashita, S Sakamoto
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Oxidative Stress : CK(14758) : AC(5716)
Therapeutic Actions : Exercise : CK(6919) : AC(1026)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Superoxide Dismutase Up-regulation : CK(2383) : AC(928)

Curcumin supplementation to aluminum treated rats was able to normalize significantly the activities of all the three mitochondrial complexes.

Pubmed Data : Neurotox Res. 2011 Nov ;20(4):351-61. Epub 2011 Jun 9. PMID: 21656326
Article Published Date : Oct 31, 2011
Authors : Pooja Khanna Sood, Uma Nahar, Bimla Nehru
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aluminum Toxicity : CK(735) : AC(318), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)
Problem Substances : Aluminum : CK(1075) : AC(356)

Curcumin suppresses chemically-induced oxidative stress in the mouse liver.

Pubmed Data : Prog Biophys Mol Biol. 2007 Jan-Apr;93(1-3):295-300. Epub 2006 Aug 22. PMID: 11234915
Article Published Date : Jan 01, 2007
Authors : S Watanabe, T Fukui
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Enzyme Inhibitors : CK(846) : AC(399), Hepatoprotective : CK(8989) : AC(3831)

Curcumin was shown to have positive effects on lifespan extension in animal studies.

Pubmed Data : Biofactors. 2013 Jan-Feb;39(1):133-40. Epub 2013 Jan 17. PMID: 23325575
Article Published Date : Dec 31, 2012
Authors : Li-Rong Shen, Laurence D Parnell, Jose M Ordovas, Chao-Qiang Lai
Study Type : Animal Study, Insect Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Tetrahydrocurcumin : CK(173) : AC(99)
Diseases : Aging : CK(6221) : AC(1510), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Superoxide Dismutase Up-regulation : CK(2383) : AC(928)
Additional Keywords : Gene Expression Regulation : CK(1401) : AC(623), Longevity : CK(4) : AC(2)

Curcumin works synergistically with drugs as an anti-fibrotic agent in liver fibrosis.

Pubmed Data : Zhong Yao Cai. 2003 Nov;26(11):795-8. PMID: 14989060
Article Published Date : Nov 01, 2003
Authors : Weifeng Yang, Houchang Chen, Yiping Jiang
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Fibrosis : CK(882) : AC(399), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Antiproliferative : CK(10001) : AC(7491)
Additional Keywords : Drug Synergy : CK(389) : AC(174)

Curcumin, capsaicin and garlic inhibit adverse blood and liver changes associated wtih a high-fat diet in rats.

Pubmed Data : Ann Nutr Metab. 2004 Sep-Oct;48(5):314-20. Epub 2004 Oct 1. PMID: 15467281
Article Published Date : Sep 01, 2004
Authors : R K Kempaiah, K Srinivasan
Study Type : Animal Study
Additional Links
Substances : Capsaicin : CK(338) : AC(129), Curcumin : CK(7239) : AC(3319), Garlic : CK(2194) : AC(727)
Diseases : Hyperlipidemia : CK(2140) : AC(553), Liver Disease : CK(367) : AC(117), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin, ellagic acid and bixin attenuate radiation induced toxicity.

Pubmed Data : Indian J Exp Biol. 1996 Sep;34(9):845-7. PMID: 9014516
Article Published Date : Sep 01, 1996
Authors : K C Thresiamma, J George, R Kuttan
Study Type : Animal Study
Additional Links
Substances : Bixin : CK(50) : AC(30), Carotenoids : CK(4462) : AC(1222), Curcumin : CK(7239) : AC(3319), Ellagic Acid : CK(540) : AC(294)
Diseases : Oxidative Stress : CK(14758) : AC(5716), Radiation Induced Illness : CK(1352) : AC(366)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Radioprotective : CK(2398) : AC(713)

Curcumin, resveratrol and melatonin protect against cadmium-induced oxidative damage.

Pubmed Data : Toxicology. 2006 Aug 15;225(2-3):150-6. Epub 2006 May 26. PMID: 16806632
Article Published Date : Aug 15, 2006
Authors : Vladislav Eybl, Dana Kotyzova, Jaroslav Koutensky
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Melatonin : CK(2891) : AC(911), Resveratrol : CK(3228) : AC(1513)
Diseases : Cadmium Poisoning : CK(439) : AC(225), Lipid Peroxidation : CK(2057) : AC(806), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Stilbenes : CK(406) : AC(244)

Curcumin-manganese complexes have enhanced antioxidant activity.

Pubmed Data : Free Radic Biol Med. 2003 Dec 15;35(12):1632-44. PMID: 14680686
Article Published Date : Dec 15, 2003
Authors : Opa Vajragupta, Preecha Boonchoong, Hiroshi Watanabe, Michihisa Tohda, Naparat Kummasud, Yaowared Sumanont
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Manganese : CK(25) : AC(5)
Diseases : Lipid Peroxidation : CK(2057) : AC(806), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)
Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

Curcuminoids have anti-tumor and antioxidant activity.

Pubmed Data : Cancer Lett. 1995 Jul 20;94(1):79-83. PMID: 7621448
Article Published Date : Jul 20, 1995
Authors : A J Ruby, G Kuttan, K D Babu, K N Rajasekharan, R Kuttan
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Breast Cancer : CK(8297) : AC(3043), Oxidative Stress : CK(14758) : AC(5716), Tumors : CK(205) : AC(120)
Pharmacological Actions : Anti-Tumor : CK(167) : AC(78), Antioxidants : CK(34551) : AC(14499)

Curcuminoids may be used to ameliorate oxidative damage in patients with beta-thalassemia/Hb E disease.

Pubmed Data : Clin Biochem. 2010 Mar;43(4-5):424-9. Epub 2009 Nov 10. PMID: 19900435
Article Published Date : Mar 01, 2010
Authors : Ruchaneekorn W Kalpravidh, Noppadol Siritanaratkul, Praphaipit Insain, Ratiya Charoensakdi, Narumol Panichkul, Suneerat Hatairaktham, Somdet Srichairatanakool, Chada Phisalaphong, Eliezer Rachmilewitz, Suthat Fucharoen
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Hemoglobinopathies : CK(20) : AC(2), Oxidative Stress : CK(14758) : AC(5716), Thalassemia : CK(229) : AC(28)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Enzyme Inhibitors : CK(846) : AC(399)

Curcuminoids positively modulates oxidative damage and mitochondrial dysfunction in diabetic rat brain.

Pubmed Data : Free Radic Res. 2008 Nov;42(11-12):999-1005. PMID: 19031318
Article Published Date : Nov 01, 2008
Authors : Manisha Rastogi, Rudra P Ojha, G V Rajamanickam, Aruna Agrawal, Abha Aggarwal, G P Dubey
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Flavonoids : CK(4698) : AC(2176), Polyphenols : CK(2736) : AC(1003)
Diseases : Diabetes: Cognitive Dysfunction : CK(387) : AC(153), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Dietary curcumin ameliorates aging-related cerebrovascular dysfunction through the AMPK/uncoupling protein 2 pathway.

Pubmed Data : Cell Physiol Biochem. 2013 ;32(5):1167-77. Epub 2013 Nov 11. PMID: 24335167
Article Published Date : Dec 31, 2012
Authors : Yunfei Pu, Hexuan Zhang, Peijian Wang, Yu Zhao, Qiang Li, Xing Wei, Yuanting Cui, Jing Sun, Qianhui Shang, Daoyan Liu, Zhiming Zhu
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Brain Inflammation : CK(1784) : AC(928), Cerebrovascular Disorders : CK(36) : AC(7), Ischemia : CK(626) : AC(325), Neurodegenerative Diseases : CK(13103) : AC(4279), Oxidative Stress : CK(14758) : AC(5716), Stroke : CK(4410) : AC(773)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949), Neurorestorative : CK(71) : AC(21)

Dietary curcumin supplementation attenuates hepatic damage and function abnormality in a chronic corticosterone-induced stress model in broilers.

Pubmed Data : J Steroid Biochem Mol Biol. 2024 Oct ;243:106579. Epub 2024 Jul 19. PMID: 39032671
Article Published Date : Sep 30, 2024
Authors : Xuemei Shan, Xingyu Xu, Lijun Wang, Yao Lu, Xinyu Chen, Fei Li, Min Du, Hua Xing, Shifeng Pan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

EGCG and curcumin suppress Alzheimer disease associated beta amyloid production.

Pubmed Data : Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H715-21. Epub 2005 Mar 18. PMID: 18695518
Article Published Date : Aug 01, 2005
Authors : Yoshiari Shimmyo, Takeshi Kihara, Akinori Akaike, Tetsuhiro Niidome, Hachiro Sugimoto
Study Type : In Vitro Study
Additional Links
Substances : Catechin : CK(965) : AC(313), Curcumin : CK(7239) : AC(3319)
Diseases : Alzheimer's Disease : CK(5355) : AC(2210), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Enzyme Inhibitors : CK(846) : AC(399), Neuroprotective Agents : CK(20061) : AC(7949)

Embelin and curcumin have a beneficial effect against oxidative tissue damage during chemically-induced hepatocarinogenesis in rats.

Pubmed Data : Mol Cell Biochem. 2006 Mar;284(1-2):49-55. Epub 2006 Feb 14. PMID: 16477385
Article Published Date : Mar 01, 2006
Authors : Meenakshisundaram Sreepriya, Geetha Bali
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Embelia ribes : CK(16) : AC(8)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Drug Synergy : CK(389) : AC(174)

Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis.

Pubmed Data : J Nanobiotechnology. 2025 Feb 7 ;23(1):89. Epub 2025 Feb 7. PMID: 39915858
Article Published Date : Feb 06, 2025
Authors : Weiwei Tang, Xiaomin Huang, Yun-Di Yi, Fan Cao, Manli Deng, Jiawei Fan, Zheng-Xuan Jiang, Li-Ming Tao, Xianwen Wang, Lei Shi
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Hyaluronic Acid : CK(249) : AC(39)
Diseases : Oxidative Stress : CK(14758) : AC(5716), Uveitis : CK(156) : AC(40)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Heme oxygenase-1 up-regulation : CK(1336) : AC(776), Nrf2 activation : CK(3156) : AC(1794)

Melatonin, curcumin, quercetin, and resveratrol ameliorate chemically-induced kidney damage.

Pubmed Data : Neuro Endocrinol Lett. 2007 Dec;28(6):739-44. PMID: 18684806
Article Published Date : Dec 01, 2007
Authors : V Eybl, D Kotyzová, P Cerná, J Koutensky
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Melatonin : CK(2891) : AC(911), Quercetin : CK(1876) : AC(855), Resveratrol : CK(3228) : AC(1513)
Diseases : Kidney Damage : CK(805) : AC(359), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Renoprotective : CK(4544) : AC(1971)
Additional Keywords : Stilbenes : CK(406) : AC(244)

Meta-analysis of randomized controlled trials of 4 weeks or longer suggest that curcumin may afford some protection against oxidative stress.

Pubmed Data : Nutr Res. 2018 12 ;60:1-12. Epub 2018 Sep 4. PMID: 30527253
Article Published Date : Jan 11, 2018
Authors : Si Qin, Lifan Huang, Jiaojiao Gong, Shasha Shen, Juan Huang, Yao Tang, Hong Ren, Huaidong Hu
Study Type : Meta Analysis
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Malondialdehyde Down-regulation : CK(3028) : AC(992)

MiR-125b-5p is targeted by curcumin to regulate the cellular antioxidant capacity.

Pubmed Data : Free Radic Res. 2022 Dec 30:1-11. Epub 2022 Dec 30. PMID: 36583645
Article Published Date : Dec 29, 2022
Authors : Lingli Lin, Xi Chen, Xiaoting Sun, Baoping Xiao, Jian Li, Jingwen Liu, Guiling Li
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), MicroRNA modulator : CK(1560) : AC(897)

NAC and curcumin protect against malathion-induced toxicity in human peripheral blood mononuclear cells.

Pubmed Data : Toxicol In Vitro. 2009 Oct;23(7):1319-25. Epub 2009 Jul 14. PMID: 19607909
Article Published Date : Oct 01, 2009
Authors : Tanzeel Ahmed, Ashok K Tripathi, Sanvidhan G Suke, Vivek Kumar, Rafat S Ahmed, Shukla Das, Basu Dev Banerjee
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), NAC (N-acetyl-L-cysteine) : CK(1429) : AC(366)
Diseases : Oxidative Stress : CK(14758) : AC(5716), Pesticide Toxicity : CK(1467) : AC(478)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Apoptotic : CK(9585) : AC(7379)

Palliative effect of curcumin on doxorubicin-induced testicular damage in male rats.

Pubmed Data : J Biochem Mol Toxicol. 2019 Oct ;33(10):e22384. Epub 2019 Aug 30. PMID: 31468665
Article Published Date : Sep 30, 2019
Authors : Emrah Hicazi Aksu, Fatih Mehmet Kandemir, Serkan Yıldırım, Sefa Küçükler, Muhammed Baheeddin Dörtbudak, Cüneyt Çağlayan, Fulya Benzer
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(845) : AC(423), Oxidative Stress : CK(14758) : AC(5716), Testicular Injury: Chemical/Metal Induced : CK(774) : AC(385)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Chemoprotective Agents : CK(4278) : AC(1621), Malondialdehyde Down-regulation : CK(3028) : AC(992)

Piperine displays the more anti-oxidative, anti-apoptotic and chemo-protective properties in the DLM induced splenic apoptosis as compared to curcumin.

Pubmed Data : Pestic Biochem Physiol. 2015 Mar ;119:16-27. Epub 2015 Mar 10. PMID: 25868812
Article Published Date : Feb 28, 2015
Authors : Anoop Kumar, Neelima Sharma
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Piperine : CK(600) : AC(258)
Diseases : Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Antioxidants : CK(34551) : AC(14499)
Problem Substances : Deltamethrin : CK(45) : AC(21)

Pretreatment with curcumin induces Nrf2 and an antioxidant response that may play an important role in the protective effect of this antioxidant against hemin-induced neuronal death.

Pubmed Data : Oxid Med Cell Longev. 2013 ;2013:801418. Epub 2013 Dec 22. PMID: 24454990
Article Published Date : Dec 31, 2012
Authors : Susana González-Reyes, Silvia Guzmán-Beltrán, Omar Noel Medina-Campos, José Pedraza-Chaverri
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Heme oxygenase-1 up-regulation : CK(1336) : AC(776), Neuroprotective Agents : CK(20061) : AC(7949), Nrf2 activation : CK(3156) : AC(1794), Superoxide Dismutase Up-regulation : CK(2383) : AC(928)

Protective effect of curcumin on zebrafish liver under ethanol-induced oxidative stress.

Pubmed Data : Comp Biochem Physiol C Toxicol Pharmacol. 2022 May 3:109360. Epub 2022 May 3. PMID: 35523403
Article Published Date : May 02, 2022
Authors : Lei Song, Ming Li, Chi Feng, Rigaiqiqige Sa, Xiaodong Hu, Jie Wang, Xiaoyu Yin, Chelimuge Qi, Wu Dong, Jingfeng Yang
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alcoholic Liver Disease : CK(611) : AC(283), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Protective effects of curcumin and silymarin against paracetamol induced hepatotoxicity.

Pubmed Data : Gene. 2019 Sep 5 ;712:143966. Epub 2019 Jul 4. PMID: 31279711
Article Published Date : Sep 04, 2019
Authors : Marwa M Ahmad, Noha A Rezk, Amal Fawzy, Mohamed Sabry
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Silymarin : CK(455) : AC(112)
Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669), Plant Extracts : CK(18762) : AC(6782)
Problem Substances : Plant Extracts : CK(18762) : AC(6782), Paracetamol : CK(863) : AC(298)

Retinal protective effect of curcumin metabolite hexahydrocurcumin against blue light-induced RPE damage.

Pubmed Data : Phytomedicine. 2023 Feb ;110:154606. Epub 2022 Dec 15. PMID: 36584606
Article Published Date : Jan 31, 2023
Authors : Yi-Hsiung Lin, Shwu-Jiuan Sheu, Wangta Liu, Yun-Tzu Hsu, Chen-Xi He, Chang-Yi Wu, Kuo-Jen Chen, Po-Yen Lee, Chien-Chih Chiu, Kai-Chun Cheng
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Blue Light Toxicity : CK(119) : AC(41), Macular Degeneration : CK(604) : AC(173), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)
Anti Therapeutic Actions : Blue Light (400−495 nm) : CK(378) : AC(106)

Sulforaphane and curcumin protect against malathion toxicity.

Pubmed Data : Eur Rev Med Pharmacol Sci. 2012 Jul ;16 Suppl 3:144-8. PMID: 22957429
Article Published Date : Jun 30, 2012
Authors : H Alp, I Aytekin, N K Hatipoglu, A Alp, M Ogun
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Sulforaphane : CK(1344) : AC(630)
Diseases : Malathion Toxicity : CK(2) : AC(1), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Synergistic effect of black tea and curcumin in improving the hepatotoxicity induced by aflatoxin B1.

Pubmed Data : Toxicol Ind Health. 2015 Dec ;31(12):1269-80. Epub 2013 Jun 24. PMID: 23796760
Article Published Date : Nov 30, 2015
Authors : Abeer A Alm-Eldeen, Mohamed H Mona, Ali A Shati, Haitham I El-Mekkawy
Study Type : Animal Study
Additional Links
Substances : Black Tea : CK(1050) : AC(265), Curcumin : CK(7239) : AC(3319)
Diseases : Lipid Peroxidation : CK(2057) : AC(806), Liver Damage: Aflatoxin-Induced : CK(104) : AC(48), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)
Problem Substances : Aflatoxin : CK(230) : AC(87)

Synergistic effects of a novel combination of natural compounds prevent H2O2-induced oxidative stress in red blood cells.

Pubmed Data : Int J Mol Sci. 2025 Feb 5 ;26(3). Epub 2025 Feb 5. PMID: 39941102
Article Published Date : Feb 04, 2025
Authors : Giuditta Benincasa, Paola Bontempo, Ugo Trama, Claudio Napoli
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Vitamin C : CK(6066) : AC(1408), Vitamin E : CK(3040) : AC(571)
Diseases : Hydrogen Peroxide Induced Toxicity : CK(437) : AC(349), Lipid Peroxidation : CK(2057) : AC(806), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

Tetrahydrocurcumin ameliorates tacrolimus-induced nephrotoxicity via inhibiting apoptosis.

Pubmed Data : Transplant Proc. 2018 Nov ;50(9):2854-2859. Epub 2018 Mar 16. PMID: 30401411
Article Published Date : Oct 31, 2018
Authors : C S Park, H J Jang, J H Lee, M Y Oh, H J Kim
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Tetrahydrocurcumin : CK(173) : AC(99)
Diseases : Kidney Damage: Chemically-Induced : CK(561) : AC(281), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Antioxidants : CK(34551) : AC(14499), Renoprotective : CK(4544) : AC(1971)

Tetrahydrocurcumin protect against radiation-induced lipid peroxidation.

Pubmed Data : Appl Physiol Nutr Metab. 2009 Dec;34(6):1093-7. PMID: 10803946
Article Published Date : Dec 01, 2009
Authors : S M Khopde, K I Priyadarsini, S N Guha, J G Satav, P Venkatesan, M N Rao
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Tetrahydrocurcumin : CK(173) : AC(99)
Diseases : Lipid Peroxidation : CK(2057) : AC(806), Oxidative Stress : CK(14758) : AC(5716), Radiation Induced Illness : CK(1352) : AC(366)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Tetrahydrocurcumin protects against oxidative damage associated with chemical exposure.

Pubmed Data : Basic Clin Pharmacol Toxicol. 2006 Nov;99(5):329-34. PMID: 17076682
Article Published Date : Nov 01, 2006
Authors : Leelavinothan Pari, Pidaran Murugan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Kidney Damage : CK(805) : AC(359), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Renoprotective : CK(4544) : AC(1971)

Tetrahydrocurcumin protects against oxidative stress in cholesterol-fed rabbits.

Pubmed Data : J Atheroscler Thromb. 2002;9(5):243-50. PMID: 12409634
Article Published Date : Jan 01, 2002
Authors : Michitaka Naito, Xiaohong Wu, Hideki Nomura, Michiteru Kodama, Yuriko Kato, Yoji Kato, Toshihiko Osawa
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Tetrahydrocurcumin : CK(173) : AC(99)
Diseases : Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients with ischemic stroke.

Pubmed Data : Nutr J. 2023 Dec 11 ;22(1):69. Epub 2023 Dec 11. PMID: 38082237
Article Published Date : Dec 10, 2023
Authors : Kosar Boshagh, Fariborz Khorvash, Amirhossein Sahebkar, Muhammed Majeed, Nimah Bahreini, Gholamreza Askari, Mohammad Bagherniya
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Piperine : CK(600) : AC(258)
Diseases : C-Reactive Protein : CK(3950) : AC(392), Oxidative Stress : CK(14758) : AC(5716), Stroke: Ischemic : CK(1030) : AC(284)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

The study demonstrated that curcumin was a potent protective compound against the nicotine-induced stress.

Pubmed Data : Mol Biol Rep. 2015 Dec ;42(12):1623-37. Epub 2015 Nov 11. PMID: 26559197
Article Published Date : Nov 30, 2015
Authors : Moumita Maiti, Krishna Chattopadhyay, Mukesh Verma, Brajadulal Chattopadhyay
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Nicotine/Tobacco Toxicity : CK(273) : AC(108), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Immunomodulatory : CK(6531) : AC(2360)

Theracurmin Super effectively reduced oxidative stress before and after exercise.

Pubmed Data : Integr Med Res. 2025 Mar ;14(1):101099. Epub 2024 Nov 15. PMID: 39897573
Article Published Date : Feb 28, 2025
Authors : Xinxing Li, Dae Young Kim, Yunho Sung, Donghyun Kim, Seohyun Ahn, Hyejung Shin, Nur Afiqah Binti Zulkifli, Ji-Won Seo, Shu Jiang, Parivash Jamrasi, SoYoung Ahn, Jun Hyun Bae, HeeKyung Yeo, Hayoung Park, Wook Song
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Oxidative Stress : CK(14758) : AC(5716)
Therapeutic Actions : Exercise : CK(6919) : AC(1026)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

These studies show that ultrasoluble curcumin and turmeric could prove useful as a therapeutic intervention in systemic lupus erythematosus and Sjogren's syndrome.

Pubmed Data : Lupus Sci Med. 2015 ;2(1):e000114. Epub 2015 Sep 8. PMID: 26380101
Article Published Date : Dec 31, 2014
Authors : Biji T Kurien, Valerie M Harris, Syed M S Quadri, Patricia Coutinho-de Souza, Joshua Cavett, Amanda Moyer, Bilal Ittiq, Angela Metcalf, Husayn F Ramji, Dat Truong, Ramesh Kumar, Kristi A Koelsch, Mike Centola, Adam Payne, Debashish Danda, R Hal Scofield
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Lupus Erythematosus: Systemic : CK(787) : AC(139), Lymphadenopathy : CK(10) : AC(4), Oxidative Stress : CK(14758) : AC(5716), Proteinuria : CK(177) : AC(33), Sjogren's Syndrome : CK(167) : AC(38)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Renoprotective : CK(4544) : AC(1971)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Thymoquinone and curcumin defeat aging-associated oxidative alterations induced by D-galactose.

Pubmed Data : Int J Mol Sci. 2021 Jun 25 ;22(13). Epub 2021 Jun 25. PMID: 34202112
Article Published Date : Jun 24, 2021
Authors : Ali H El-Far, Yaser H A Elewa, Elsayeda-Zeinab A Abdelfattah, Abdel-Wahab A Alsenosy, Mustafa S Atta, Khalid M Abou-Zeid, Soad K Al Jaouni, Shaker A Mousa, Ahmed E Noreldin
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Thymoquinone : CK(1178) : AC(692)
Diseases : Aging : CK(6221) : AC(1510), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963), Neuroprotective Agents : CK(20061) : AC(7949)

Turmeric and curcumin appear to be beneficial in preventing diabetes-induced oxidative stress in rats.

Pubmed Data : Med Sci Monit. 2007 Dec;13(12):BR286-92. PMID: 18049430
Article Published Date : Dec 01, 2007
Authors : Palla Suryanarayana, Alleboena Satyanarayana, Nagalla Balakrishna, Putcha Uday Kumar, Geereddy Bhanuprakash Reddy
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Diabetes: Oxidative Stress : CK(635) : AC(244), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Turmeric prevents oxidative stress induced kidney cell damage.

Pubmed Data : Free Radic Biol Med. 1998 Jan 1;24(1):49-54. PMID: 9436613
Article Published Date : Jan 01, 1998
Authors : H H Cohly, A Taylor, M F Angel, A K Salahudeen
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Kidney Damage : CK(805) : AC(359), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Renoprotective : CK(4544) : AC(1971)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Turmeric reduces oxidative stress and attenuates aortic fatty streak development in rabbits.

Pubmed Data : Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1225-31. PMID: 12117742
Article Published Date : Jul 01, 2002
Authors : José L Quiles, M Dolores Mesa, César L Ramírez-Tortosa, Concepción M Aguilera, Maurizio Battino, Angel Gil, M Carmen Ramírez-Tortosa
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Aortic Plaques : CK(27) : AC(10), Arteriosclerosis : CK(522) : AC(144), Cholesterol: Oxidation : CK(654) : AC(159), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Various antioxidants may ameliorate napthalene-induced toxicity.

Pubmed Data : Toxicology. 2002 Oct 30;180(1):97-105. PMID: 12324202
Article Published Date : Oct 30, 2002
Authors : Sidney J Stohs, Sunny Ohia, Debasis Bagchi
Study Type : Commentary
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Cysteine (see N-Acetylcysteine) : CK(111) : AC(33), Melatonin : CK(2891) : AC(911), Vitamin E : CK(3040) : AC(571)
Diseases : Napthalene-Induced Toxicity : CK(3) : AC(2), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcuma as an adjuvant in colorectal cancer treatment.

Pubmed Data : Life Sci. 2021 Dec 1 ;286:120043. Epub 2021 Oct 9. PMID: 34637800
Article Published Date : Nov 30, 2021
Authors : Cecilia Villegas, Rebeca Perez, Olov Sterner, Iván González-Chavarría, Cristian Paz
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Colorectal Cancer : CK(4889) : AC(2276)
Pharmacological Actions : Antineoplastic Agents : CK(2235) : AC(1468), Antioxidants : CK(34551) : AC(14499), NF-kappaB Inhibitor : CK(5952) : AC(3464)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Curcumin exhibits anti-metastatic properties in breast cancer cells.

Pubmed Data : Carcinogenesis. 2008 Apr;29(4):779-89. Epub 2007 Nov 13. PMID: 17999991
Article Published Date : Apr 01, 2008
Authors : Beatrice E Bachmeier, Isabelle V Mohrenz, Valentina Mirisola, Erwin Schleicher, Francesco Romeo, Clara Höhneke, Marianne Jochum, Andreas G Nerlich, Ulrich Pfeffer
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Breast Cancer : CK(8297) : AC(3043), Cancer Metastasis : CK(961) : AC(542)
Pharmacological Actions : Anti-metastatic : CK(2870) : AC(2182), Antioxidants : CK(34551) : AC(14499), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin exhibits chemopreventive properties against cholangiocarcinoma cells.

Pubmed Data : Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2265-72. Epub 2010 May 25. PMID: 20510329
Article Published Date : Aug 01, 2010
Authors : Bunliang Suphim, Auemduan Prawan, Upa Kukongviriyapan, Sarinya Kongpetch, Benjaporn Buranrat, Veerapol Kukongviriyapan
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cholangiocarcinoma : CK(213) : AC(91)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379), Chemopreventive : CK(6580) : AC(2166), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin exhibits inhibitory effects liver fibrosis associated with injury.

Pubmed Data : Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G20-30. Epub 2003 Mar 26. PMID: 12660143
Article Published Date : Jul 01, 2003
Authors : Jianye Xu, Yumei Fu, Anping Chen
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Fibrosis : CK(882) : AC(399)
Pharmacological Actions : Antineoplastic Agents : CK(2235) : AC(1468), Antioxidants : CK(34551) : AC(14499), Antiproliferative : CK(10001) : AC(7491), Hepatoprotective : CK(8989) : AC(3831), NF-kappaB Inhibitor : CK(5952) : AC(3464)
Additional Keywords : Drug Synergy : CK(389) : AC(174)

Curcumin prevents diabetes-associated abnormalities in the kidneys.

Pubmed Data : Nutrition. 2009 Sep;25(9):964-72. Epub 2009 Mar 5. PMID: 19268536
Article Published Date : Sep 01, 2009
Authors : Jane Chiu, Zia A Khan, Hana Farhangkhoee, Subrata Chakrabarti
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), NF-kappaB Inhibitor : CK(5952) : AC(3464), Renoprotective : CK(4544) : AC(1971)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Curcumin prevents shock-wave lithotripsy-induced renal injury.

Pubmed Data : Urol Res. 2009 Jun;37(3):159-64. Epub 2009 Apr 2. PMID: 19340419
Article Published Date : Jun 01, 2009
Authors : Muzaffer Bas, Volkan Tugcu, Eray Kemahli, Emin Ozbek, Mehmet Uhri, Tuncay Altug, Ali I Tasci
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Kidney Stones : CK(273) : AC(61), Shock wave lithotripsy (SWL)-induced damage : CK(2) : AC(1)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), NF-kappaB Inhibitor : CK(5952) : AC(3464), Nitric Oxide Inhibitor : CK(705) : AC(356)

Curcumin attenuates LPS-induced sickness behavior.

Pubmed Data : Neurosci Lett. 2022 May 11 ;781:136680. Epub 2022 May 11. PMID: 35568344
Article Published Date : May 10, 2022
Authors : Letícia Reis, Merelym K Oliveira, Viviana Carolina T Rojas, Tatiane H Batista, Elisa S Estevam, Fernando Vitor-Vieira, Fabiana C Vilela, Alexandre Giusti-Paiva
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Nrf2 activation : CK(3156) : AC(1794)

Curcumin abrogated cancer associated fibroblast induced invasion and EMT, and inhibited ROS production and CXCR4 and IL-6 receptor expression in prostate cancer cells.

Pubmed Data : Int J Oncol. 2015 Oct 13. Epub 2015 Oct 13. PMID: 26499200
Article Published Date : Oct 12, 2015
Authors : Yuefeng Du, Qingzhi Long, Lin Zhang, Ying Shi, Xioagang Liu, Xudong Li, Bin Guan, Yanchao Tian, Xinyang Wang, Lei Li, Dalin He
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Prostate Cancer : CK(2805) : AC(1046)
Pharmacological Actions : Anti-metastatic : CK(2870) : AC(2182), Antioxidants : CK(34551) : AC(14499), Chemotherapeutic : CK(4390) : AC(1635)

Curcumin and NAC protect against valproate-induced liver toxicity.

Pubmed Data : Arzneimittelforschung. 2010;60(11):647-53. PMID: 21175036
Article Published Date : Jan 01, 2010
Authors : Shehta Abd-Allah Said, Dina Saad El-Agamy
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), NAC (N-acetyl-L-cysteine) : CK(1429) : AC(366)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Drug-Induced Toxicity: Valproic Acid (Depakote) : CK(8) : AC(4)
Pharmacological Actions : Anticonvulsants : CK(1163) : AC(299), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Mechanism of Curcuma longa and its neuroactive components for the management of epileptic seizures.

Pubmed Data : Curr Neuropharmacol. 2021 May 17. Epub 2021 May 17. PMID: 33998991
Article Published Date : May 16, 2021
Authors : Brandon Kar Meng Choo, Mohd Farooq Shaikh
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Epilepsy : CK(1199) : AC(327)
Pharmacological Actions : Anticonvulsants : CK(1163) : AC(299), Antioxidants : CK(34551) : AC(14499)

Mechanistic insight of curcumin: a potential pharmacological candidate for epilepsy.

Pubmed Data : Front Pharmacol. 2024 ;15:1531288. Epub 2025 Jan 7. PMID: 39845785
Article Published Date : Dec 31, 2023
Authors : Saima Khatoon, Nida Kalam
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Epilepsy : CK(1199) : AC(327)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anticonvulsants : CK(1163) : AC(299), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin is a nitric oxide scavenger.

Pubmed Data : Gynecol Oncol. 2004 Sep;94(3):760-8. PMID: 9120760
Article Published Date : Sep 01, 2004
Authors : Sreejayan, M N Rao
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Nitric Oxide Inhibitor : CK(705) : AC(356)

The potential of turmeric extract-loaded chitosan microparticles for the treatment of gastrointestinal disorders.

Pubmed Data : J Microencapsul. 2024 Nov ;41(7):547-563. Epub 2024 Aug 14. PMID: 39140474
Article Published Date : Oct 31, 2024
Authors : Pimonsri Mittraparp-Arthorn, Suwipa Ungphaiboon, Chutha Takahashi Yupanqui, Sirikan Suwannasin, Chutikan Wijukkul, Niwan Tanmanee, Teerapol Srichana
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Gastrointestinal Diseases : CK(211) : AC(73)
Pharmacological Actions : Anti-Bacterial Agents : CK(4228) : AC(1989), Antioxidants : CK(34551) : AC(14499), Gastrointestinal Agents : CK(7657) : AC(2274), Nitric Oxide Inhibitor : CK(705) : AC(356)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Dietary tetrahydrocurcumin reduces renal fibrosis and cardiac hypertrophy.

Pubmed Data : Pharmacol Res Perspect. 2018 04 ;6(2):e00385. Epub 2018 Feb 19. PMID: 29468071
Article Published Date : Dec 31, 2017
Authors : Wei Ling Lau, Mahyar Khazaeli, Javad Savoj, Kasim Manekia, Maria Bangash, Roshni G Thakurta, Anhthu Dang, Nosratola D Vaziri, Bhupinder Singh
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Tetrahydrocurcumin : CK(173) : AC(99)
Diseases : Cardiac Hypertrophy : CK(248) : AC(135), Fibrosis : CK(383) : AC(185)
Pharmacological Actions : Anti-Fibrotic : CK(2209) : AC(1052), Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963)

The anticancer potential of tetrahydrocurcumin-phytosomes against oral carcinoma progression.

Pubmed Data : BMC Oral Health. 2024 Sep 26 ;24(1):1126. Epub 2024 Sep 26. PMID: 39327561
Article Published Date : Sep 25, 2024
Authors : Nehal Raouf, Zeinab Elsayed Darwish, Omneya Ramadan, Hebatallah S Barakat, Shimaa A Elbanna, Marwa M Essawy
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Tetrahydrocurcumin : CK(173) : AC(99)
Diseases : Oral Cancer : CK(717) : AC(384), Squamous cell carcinoma : CK(676) : AC(348)
Pharmacological Actions : Antineoplastic Agents : CK(2235) : AC(1468), Antioxidants : CK(34551) : AC(14499), Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379)

Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in male mice, indicating its protective value against chemical carcinogenesis and toxicity.

Pubmed Data : Pharmacol Toxicol. 2003 Jan;92(1):33-8. PMID: 12710595
Article Published Date : Jan 01, 2003
Authors : Mohammad Iqbal, Som Datta Sharma, Yasumasa Okazaki, Masayoshi Fujisawa, Shigeru Okada
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cancers: All : CK(36404) : AC(14363)
Pharmacological Actions : Anticarcinogenic Agents : CK(2152) : AC(1018), Antioxidants : CK(34551) : AC(14499), Phase II Detoxification Enzyme Inducer : CK(100) : AC(55)

The activation of EpRE/ARE system was up to four fold higher than the sum of the activities of the single ingredients.

Pubmed Data : Arch Biochem Biophys. 2015 Apr 15 ;572:28-35. Epub 2015 Feb 21. PMID: 25711533
Article Published Date : Apr 14, 2015
Authors : Karin Linnewiel-Hermoni, Marina Khanin, Michael Danilenko, Gabriel Zango, Yaara Amosi, Joseph Levy, Yoav Sharoni
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid : CK(167) : AC(112), Carotenoids : CK(4462) : AC(1222), Curcumin : CK(7239) : AC(3319), Flavonoids : CK(4698) : AC(2176), Lycopene : CK(1267) : AC(372), Polyphenols : CK(2736) : AC(1003)
Diseases : Cancers: All : CK(36404) : AC(14363), Prostate Cancer : CK(2805) : AC(1046)
Pharmacological Actions : Antineoplastic Agents : CK(2235) : AC(1468), Antioxidants : CK(34551) : AC(14499), Antiproliferative : CK(10001) : AC(7491)
Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

Curcumin and hesperetin attenuate D-galactose-induced brain senescence in vitro and in vivo

Pubmed Data : Nutr Res Pract. 2020 Oct ;14(5):438-452. Epub 2020 Aug 6. PMID: 33029285
Article Published Date : Sep 30, 2020
Authors : Jihye Lee, Yoo Sun Kim, Eunju Kim, Yerin Kim, Yuri Kim
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Flavonoids : CK(4698) : AC(2176)
Diseases : Neurodegenerative Diseases : CK(13103) : AC(4279)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

These findings suggest that curcumin may be used as an adjunct therapy in individuals with oxidative stress.

Pubmed Data : Biomedicine (Taipei). 2019 Dec ;9(4):23. Epub 2019 Nov 14. PMID: 31724938
Article Published Date : Nov 30, 2019
Authors : Mohammad Alizadeh, Sorayya Kheirouri
Study Type : Meta Analysis
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Brain: Oxidative Stress : CK(644) : AC(347)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Malondialdehyde Down-regulation : CK(3028) : AC(992)

"Curcumin nanoparticles improve the physicochemical properties of curcumin and effectively enhance its antioxidant and antihepatoma activities."

Pubmed Data : J Agric Food Chem. 2010 Jun 23 ;58(12):7376-82. PMID: 20486686
Article Published Date : Jun 23, 2010
Authors : Feng-Lin Yen, Tzu-Hui Wu, Cheng-Wei Tzeng, Liang-Tzung Lin, Chun-Ching Lin
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Hepatoma : CK(37) : AC(32), Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Antineoplastic Agents : CK(2235) : AC(1468), Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Nanoencapsulated Curcumin : CK(5) : AC(3)

A novel curcumin derivative regenerates pancreatic islets in experimental type-1 diabetes in rats (long term study).

Pubmed Data : Diabetol Metab Syndr. 2013 ;5(1):75. Epub 2013 Nov 26. PMID: 24279645
Article Published Date : Dec 31, 2012
Authors : Mohamed T Abdel Aziz, Mohamed F El-Asmar, Ameen M Rezq, Soheir M Mahfouz, Mohamed A Wassef, Hanan H Fouad, Hanan H Ahmed, Fatma M Taha
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetes Mellitus: Type 1 : CK(2032) : AC(611), Diabetes Mellitus: Type 1: Prevention : CK(383) : AC(87)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Regenerative : CK(486) : AC(201)
Additional Keywords : Beta Cell Regeneration : CK(78) : AC(29)

A review of natural antioxidants in the management of Parkinson's disease.

Pubmed Data : J Integr Med. 2021 Mar 27. Epub 2021 Mar 27. PMID: 33863692
Article Published Date : Mar 26, 2021
Authors : Reem Abdul-Latif, Ieva Stupans, Ayman Allahham, Benu Adhikari, Thilini Thrimawithana
Study Type : Review
Additional Links
Substances : Ashwagandha : CK(748) : AC(301), Curcumin : CK(7239) : AC(3319), Ginkgo biloba : CK(2047) : AC(658), Hydroxytyrosol : CK(310) : AC(144), St. Johns Wort : CK(401) : AC(118)
Diseases : Brain: Oxidative Stress : CK(644) : AC(347), Parkinson's Disease : CK(3012) : AC(1116)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

A review of the beneficial effects of antioxidants on Helicobacter pylori eradication.

Pubmed Data : Helicobacter. 2018 Dec ;23(6):e12535. Epub 2018 Sep 6. PMID: 30191635
Article Published Date : Nov 30, 2018
Authors : Yao-Bin Yang-Ou, Yi Hu, Yin Zhu, Nong-Hua Lu
Study Type : Meta Analysis, Review
Additional Links
Substances : Cranberry : CK(712) : AC(147), Curcumin : CK(7239) : AC(3319), NAC (N-acetyl-L-cysteine) : CK(1429) : AC(366)
Diseases : Helicobacter Pylori Infection : CK(1213) : AC(275)
Pharmacological Actions : Anti-Bacterial Agents : CK(4228) : AC(1989), Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Natural Substance/Drug Synergy : CK(1526) : AC(720)

Advantages of Curcuma longa in preventing male infertility caused by thioacetamide.

Pubmed Data : Open Vet J. 2024 Jul ;14(7):1585-1595. Epub 2024 Jul 31. PMID: 39175971
Article Published Date : Jun 30, 2024
Authors : Fatima A Jaber, Fatima S Alaryani, Boudor S Almutiri, Suzan B Abdu, Arif Mohammed
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Chemical Exposure : CK(112) : AC(40), Infertility: Male : CK(1757) : AC(452)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Fertility Agents: Male : CK(455) : AC(123)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Anti-fatigue and anti-oxidant effects of curcumin supplementation in exhaustive swimming.

Pubmed Data : Curr Res Food Sci. 2022 ;5:1148-1157. Epub 2022 Jul 16. PMID: 35875345
Article Published Date : Dec 31, 2021
Authors : Yong Chen, Jiajun Wang, Ziheng Jing, Jose M Ordovas, Jing Wang, Lirong Shen
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Fatigue: Excercise-Induced : CK(674) : AC(98)
Therapeutic Actions : Exercise: Swimming : CK(141) : AC(33)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Antiobesity effects of phytochemicals from an epigenetic perspective.

Pubmed Data : Nutrition. 2020 Dec 21 ;84:111119. Epub 2020 Dec 21. PMID: 33476999
Article Published Date : Dec 20, 2020
Authors : Yildiz Dincer, Selin Yuksel
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Genistein : CK(945) : AC(434), Isothiocyanates : CK(1659) : AC(819)
Diseases : Obesity : CK(11004) : AC(2672)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Anti-Obesity Agents : CK(5172) : AC(1320), Epigenetic Modification : CK(586) : AC(216)

Antioxidant actions of thymoquinone, silymarin, and curcumin on experimental aortic ischemia-reperfusion.

Pubmed Data : Braz J Cardiovasc Surg. 2022 Jun 3. Epub 2022 Jun 3. PMID: 35657313
Article Published Date : Jun 02, 2022
Authors : Mustafa Yardımcı, Mustafa Göz, Mehmet Salih Aydın, Nazım Kankılıç, Ebru Temiz
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Silymarin : CK(455) : AC(112), Thymoquinone : CK(1178) : AC(692)
Diseases : Ischemia : CK(626) : AC(325)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Antioxidant and anti-inflammatory activity of curcumin transdermal gel in an IL-10 knockout mouse model of inflammatory bowel disease.

Pubmed Data : An Acad Bras Cienc. 2022 ;94(4):e20201378. Epub 2022 Dec 5. PMID: 36477991
Article Published Date : Dec 31, 2021
Authors : Fernanda O Araujo, Matheus B Felício, Cássio F Lima, Mayra S Piccolo, Virgínia R Pizziolo, Gaspar Diaz-Muñoz, Daniel S S Bastos, Leandro L Oliveira, Maria DO C G Peluzio, Marisa A N Diaz
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Inflammatory Bowel Diseases : CK(3196) : AC(926)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Malondialdehyde Down-regulation : CK(3028) : AC(992)

Black seed oil-based curcumin nanoformulations ameliorated cuprizone-induced demyelination in the mouse hippocampus.

Pubmed Data : Mol Neurobiol. 2024 Jun 18. Epub 2024 Jun 18. PMID: 38890237
Article Published Date : Jun 17, 2024
Authors : Mohammad Zubair Alam, Hala Abubaker Bagabir, Mohammad Alameen Faisal Zaher, Thamer M A Alqurashi, Badrah S Alghamdi, Mohsin Kazi, Ghulam Md Ashraf, Gadah Ali Alshahrany, Noor Ahmed Alzahrani, Rafal Mohammed Bakhalgi, Juweiriya, Mona Al-Thepyani, Hanin Abdulbaset AboTaleb, Rahaf Saeed Aldhahri, Gamal Said Abd El-Aziz, Fahad A Al-Abbasi, Loay Khaled Eibani, Faisal Jaman Alzahrani, Mohd Sajjad Ahmad Khan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Nigella sativa (aka Black Seed) : CK(1912) : AC(494)
Diseases : Multiple Sclerosis : CK(2432) : AC(557)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Brain targeted curcumin loaded turmeric oil microemulsion protects against trimethyltin induced neurodegeneration.

Pubmed Data : Pharm Res. 2023 Jan 26. Epub 2023 Jan 26. PMID: 36703027
Article Published Date : Jan 25, 2023
Authors : Suraj More, Atmaram Pawar
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Neurodegenerative Diseases : CK(13103) : AC(4279)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

C urcumin protects against gamma-radiation induced DNA damage and lipid peroxidation in cultured human lymphocytes.

Pubmed Data : Mutat Res. 2006 Dec 10;611(1-2):96-103. Epub 2006 Sep 14. PMID: 16973408
Article Published Date : Dec 10, 2006
Authors : M Srinivasan, N Rajendra Prasad, Venugopal P Menon
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : DNA damage : CK(2301) : AC(842), Radiation Induced Illness: Immune Suppression : CK(3) : AC(3)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Radioprotective : CK(2398) : AC(713)

Chemopreventive synergism between green tea extract and curcumin in patients with potentially malignant oral disorders.

Pubmed Data : J Contemp Dent Pract. 2020 May 1 ;21(5):521-531. Epub 2020 May 1. PMID: 32690834
Article Published Date : Apr 30, 2020
Authors : Mellekatte C Neetha, Mamatha G Panchaksharappa, Shashikala Pattabhiramasastry, Nandish V Shivaprasad, Usha G Venkatesh
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Green Tea : CK(4491) : AC(1379)
Diseases : Oral Cancer : CK(717) : AC(384)
Pharmacological Actions : Anticarcinogenic Agents : CK(2152) : AC(1018), Antioxidants : CK(34551) : AC(14499), Chemopreventive : CK(6580) : AC(2166)
Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669), Plant Extracts : CK(18762) : AC(6782)

Co-administration of antioxidant significantly increased plasma level of curcumin in animal models.

Pubmed Data : Mol Nutr Food Res. 2015 Nov 26. Epub 2015 Nov 26. PMID: 26608515
Article Published Date : Nov 25, 2015
Authors : Yoshiki Nimiya, Weicang Wang, Zheyuan Du, Elvira Sukamtoh, Julia Zhu, Eric Decker, Guodong Zhang
Study Type : Animal Study
Additional Links
Substances : Caffeic Acid : CK(136) : AC(87), Curcumin : CK(7239) : AC(3319), Gallic Acid : CK(341) : AC(212), Rosmarinic acid : CK(193) : AC(108), Vitamin C : CK(6066) : AC(1408)
Diseases : Colon Cancer : CK(1920) : AC(1203)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Antiproliferative : CK(10001) : AC(7491)
Additional Keywords : Increased Bioavailability : CK(83) : AC(34), Metabolites : CK(84) : AC(37)

Combination of vitamin C and curcumin safeguards against methotrexate-induced acute liver injury.

Pubmed Data : Front Med (Lausanne). 2022 ;9:866343. Epub 2022 Apr 14. PMID: 35492324
Article Published Date : Dec 31, 2021
Authors : Dhekra Hasan Khudhair, Ali I Al-Gareeb, Hayder M Al-Kuraishy, Aya H El-Kadem, Engy Elekhnawy, Walaa A Negm, Sameh Saber, Simona Cavalu, Adrian Tirla, Saqer S Alotaibi, Gaber El-Saber Batiha
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Vitamin C : CK(6066) : AC(1408)
Diseases : Drug Toxicity: Methotrexate : CK(194) : AC(100), Liver Damage: Drug-Induced : CK(651) : AC(285)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

Curcuma longa-loaded PCL nanoparticles have an interesting protective capacity against paraquat-induced damage.

Pubmed Data : Polymers (Basel). 2022 Sep 9 ;14(18). Epub 2022 Sep 9. PMID: 36145919
Article Published Date : Sep 08, 2022
Authors : Ana Teixeira, Marisa P Sárria, Inês Pinto, Begoña Espiña, Andreia C Gomes, Alberto C P Dias
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Paraquat Toxicity : CK(27) : AC(15), Pesticide Toxicity : CK(1467) : AC(478)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)
Problem Substances : Paraquat : CK(190) : AC(94)

Curcumin alleviated HLS-induced reduction of bone mineral density in tibiae and preserved bone structure in tibiae and mechanical strength in femurs.

Pubmed Data : Osteoporos Int. 2015 May 12. Epub 2015 May 12. PMID: 25963235
Article Published Date : May 11, 2015
Authors : M Xin, Y Yang, D Zhang, J Wang, S Chen, D Zhou
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Osteoporosis : CK(2786) : AC(758)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Vitamin D Receptor (VDR) Modulator : CK(4) : AC(3)
Additional Keywords : Microgravity Induced Bone Loss : CK(7) : AC(3)

Curcumin ameliorates aflatoin-induced toxicity in serum of mice.

Pubmed Data : Acta Pol Pharm. 2008 May-Jun;65(3):339-43. PMID: 18646553
Article Published Date : May 01, 2008
Authors : Neeta Mathuria, Ramtej Jayram Verma
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aflatoxicosis : CK(301) : AC(109)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin ameliorates aflatoxin-induced toxicity in DNA, RNA and protein in liver and kidney of mice.

Pubmed Data : Acta Pol Pharm. 2007 Nov-Dec;64(6):497-502. PMID: 18323242
Article Published Date : Nov 01, 2007
Authors : Neeta Mathuria, Ramtej Jayram Verma
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aflatoxicosis : CK(301) : AC(109)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Renoprotective : CK(4544) : AC(1971)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Curcumin ameliorates aflatoxin-induced toxicity.

Pubmed Data : Poult Sci. 2008 Jun;87(6):1125-30. PMID: 18493001
Article Published Date : Jun 01, 2008
Authors : N K S Gowda, D R Ledoux, G E Rottinghaus, A J Bermudez, Y C Chen
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aflatoxicosis : CK(301) : AC(109)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin and a curcumin copper complex has a radioprotective effect in mouse livers.

Pubmed Data : J Radiat Res (Tokyo). 2007 May;48(3):241-5. Epub 2007 Apr 27. PMID: 17464095
Article Published Date : May 01, 2007
Authors : Prabhakar R Koiram, Veeresh P Veerapur, Amit Kunwar, Beena Mishra, Atanu Barik, Indira K Priyadarsini, Unnikrishnan K Mazhuvancherry
Study Type : Animal Study
Additional Links
Substances : Copper : CK(146) : AC(30), Curcumin : CK(7239) : AC(3319)
Diseases : Radiation Induced Illness : CK(1352) : AC(366), Radiation Induced Illness: Liver : CK(2) : AC(1)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Radioprotective : CK(2398) : AC(713)

Curcumin and eugenol prevents lipid peroxidation of rat liver microsomes.

Pubmed Data : Mol Cell Biochem. 1992 Apr;111(1-2):117-24. PMID: 1588934
Article Published Date : Apr 01, 1992
Authors : A C Reddy, B R Lokesh
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Eugenol : CK(219) : AC(133)
Diseases : Lipid Peroxidation : CK(2057) : AC(806)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin and naringenin exhibit neuroprotective properties in an animal model of Parkinson's disease.

Pubmed Data : Free Radic Res. 2005 Oct;39(10):1119-25. PMID: 16298737
Article Published Date : Oct 01, 2005
Authors : Virginia Zbarsky, Krishna P Datla, Shabnam Parkar, Deepal K Rai, Okezie I Aruoma, David T Dexter
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Naringenin : CK(704) : AC(394)
Diseases : Parkinson's Disease : CK(3012) : AC(1116)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin and photobiomodulation in chronic viral hepatitis and hepatocellular carcinoma.

Pubmed Data : Int J Mol Sci. 2020 Sep 28 ;21(19). Epub 2020 Sep 28. PMID: 32998270
Article Published Date : Sep 27, 2020
Authors : Laura Marinela Ailioaie, Gerhard Litscher
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Hepatitis B : CK(422) : AC(114), Liver Cancer : CK(3119) : AC(1641), Liver Cirrhosis : CK(919) : AC(230)
Therapeutic Actions : Photobiomodulation : CK(17459) : AC(3331)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Antiviral Agents : CK(3095) : AC(1702)

Curcumin and taurine significantly minimized BPA-induced cardiotoxicity in rats.

Pubmed Data : Environ Sci Pollut Res Int. 2019 Mar 6. Epub 2019 Mar 6. PMID: 30840252
Article Published Date : Mar 05, 2019
Authors : Fatma Gökçe Apaydin, Ayşe Aslanturk, Meltem Uzunhisarcikli, Hatice Bas, Suna Kalender, Yusuf Kalender
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Taurine : CK(246) : AC(71)
Diseases : Bisphenol Toxicity : CK(4416) : AC(1329)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963)
Problem Substances : Bisphenol A : CK(4570) : AC(1323)

Curcumin and taurine significantly protect BPA induced testicular damage in rats.

Pubmed Data : Pak J Pharm Sci. 2019 May ;32(3):1043-1047. PMID: 31278718
Article Published Date : Apr 30, 2019
Authors : Suna Kalender, Fatma Gökçe Apaydin, Yusuf Kalender
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Taurine : CK(246) : AC(71)
Diseases : Bisphenol Toxicity : CK(4416) : AC(1329), Testicular Injury: Chemical/Metal Induced : CK(774) : AC(385)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Malondialdehyde Down-regulation : CK(3028) : AC(992)
Problem Substances : Bisphenol A : CK(4570) : AC(1323)

Curcumin and turmeric extract might be recommendable to recover liver activity.

Pubmed Data : Sci Rep. 2017 Jul 26 ;7(1):6513. Epub 2017 Jul 26. PMID: 28747775
Article Published Date : Jul 25, 2017
Authors : Hwa-Young Lee, Seung-Wook Kim, Geum-Hwa Lee, Min-Kyung Choi, Han-Wool Chung, Yong-Chul Lee, Hyung-Ryong Kim, Ho Jeong Kwon, Han-Jung Chae
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin and turmeric inhibit experimental tumorigenesis and DNA adduct formation.

Pubmed Data : Nutr Cancer. 1998;30(2):163-6. PMID: 9589436
Article Published Date : Jan 01, 1998
Authors : K Krishnaswamy, V K Goud, B Sesikeran, M A Mukundan, T P Krishna
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : DNA damage : CK(2301) : AC(842), Oral Cancer : CK(717) : AC(384)
Pharmacological Actions : Antineoplastic Agents : CK(2235) : AC(1468), Antioxidants : CK(34551) : AC(14499), Chemopreventive : CK(6580) : AC(2166)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Curcumin as a permeability enhancer enhanced the antihyperlipidemic activity of dietary green tea extract.

Pubmed Data : BMC Complement Altern Med. 2019 Jun 13 ;19(1):129. Epub 2019 Jun 13. PMID: 31196040
Article Published Date : Jun 12, 2019
Authors : Ashlesha P Pandit, Shreyas R Joshi, Preeti S Dalal, Vinita C Patole
Study Type : Animal Study
Additional Links
Substances : Catechin : CK(965) : AC(313), Curcumin : CK(7239) : AC(3319), EGCG (Epigallocatechin gallate) : CK(1587) : AC(820)
Diseases : Hyperlipidemia : CK(2140) : AC(553)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hypolipidemic : CK(9173) : AC(2038)
Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

Curcumin as a potential antioxidant could be an effective attenuative agent against AlP-induced oxidative damage in testis.

Pubmed Data : Pharm Nanotechnol. 2023 Mar 16. Epub 2023 Mar 16. PMID: 36927427
Article Published Date : Mar 15, 2023
Authors : Akram Ranjbar, Nejat Kheiripour, Hossein Shateri, Amirhossein Sameri, Hadi Ghasemi
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aluminum Toxicity : CK(735) : AC(318), Testicular Injury: Chemical/Metal Induced : CK(774) : AC(385)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)
Problem Substances : Aluminum : CK(1075) : AC(356)

Curcumin as a therapeutic strategy in liver diseases.

Pubmed Data : Nutrients. 2019 Oct 17 ;11(10). Epub 2019 Oct 17. PMID: 31627369
Article Published Date : Oct 16, 2019
Authors : Rita Rezzani, Caterina Franco, Luigi Fabrizio Rodella
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Disease : CK(367) : AC(117), Liver Failure: Acute : CK(57) : AC(25), Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin at 30 and 60 mg/kg dose levels significantly attenuated vincristine induced neuropathy.

Pubmed Data : Pharm Biol. 2015 Jun ;53(6):838-48. Epub 2014 Nov 28. PMID: 25429779
Article Published Date : May 31, 2015
Authors : Anand Babu, K G Prasanth, Bhaskar Balaji
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemotherapy-Induced Toxicity: Vincristine : CK(13) : AC(7)
Pharmacological Actions : Antinoceceptive : CK(959) : AC(291), Antioxidants : CK(34551) : AC(14499), Chemoprotective Agents : CK(4278) : AC(1621)

Curcumin attenuates high-fat-diet induced blood lipid elevation and oxidation.

Pubmed Data : Wei Sheng Yan Jiu. 2000 Jul;29(4):240-2. PMID: 12520931
Article Published Date : Jul 01, 2000
Authors : S Wang, B Chen, C Sun
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Hyperlipidemia : CK(2140) : AC(553), Lipid Peroxidation : CK(2057) : AC(806)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin attenuates lead-induced neurotoxicity via inhibition of oxidative stress and chelating activity.

Pubmed Data : Biomolecules. 2019 Sep 6 ;9(9). Epub 2019 Sep 6. PMID: 31489882
Article Published Date : Sep 05, 2019
Authors : Kabeer Abubakar, Maryam Muhammad Mailafiya, Abubakar Danmaigoro, Samaila Musa Chiroma, Ezamin Bin Abdul Rahim, Md Zuki Abu Bakar Zakaria
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Brain: Oxidative Stress : CK(644) : AC(347), Lead Poisoning : CK(483) : AC(182)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Chelating Agents : CK(48) : AC(25), Neuroprotective Agents : CK(20061) : AC(7949)
Problem Substances : Lead : CK(700) : AC(231)

Curcumin combined with metformin may act synergistically on dyslipidemia and oxidative stress, as well as increased PON 1 levels.

Pubmed Data : Diabetol Metab Syndr. 2019 ;11:33. Epub 2019 Apr 30. PMID: 31061679
Article Published Date : Dec 31, 2018
Authors : Daniela Fernandes Roxo, Carlos Alberto Arcaro, Vania Ortega Gutierres, Mariana Campos Costa, Juliana Oriel Oliveira, Tayra Ferreira Oliveira Lima, Renata Pires Assis, Iguatemy Lourenço Brunetti, Amanda Martins Baviera
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Dyslipidemias : CK(1626) : AC(329), Hyperglycemia : CK(2240) : AC(709)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hypoglycemic Agents : CK(9221) : AC(2076)
Additional Keywords : Natural Substance/Drug Synergy : CK(1526) : AC(720)

Curcumin compensated the adverse effects of sodium arsenite on kidney tissue, lipid peroxidation and total antioxidant capacity of serum.

Pubmed Data : Exp Toxicol Pathol. 2016 Nov 28. Epub 2016 Nov 28. PMID: 27908582
Article Published Date : Nov 27, 2016
Authors : Hamid Reza Momeni, Najmeh Eskandari
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Arsenic Poisoning : CK(383) : AC(129)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Renoprotective : CK(4544) : AC(1971)
Problem Substances : Arsenite : CK(34) : AC(20)

Curcumin could ameliorate aluminium induced testicular damage.

Pubmed Data : Int J Fertil Steril. 2017 Oct ;11(3):166-175. Epub 2017 Aug 27. PMID: 28868838
Article Published Date : Sep 30, 2017
Authors : Ebrahim Cheraghi, Alireza Golkar, Kambiz Roshanaei, Behrang Alani
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aluminum Toxicity : CK(735) : AC(318), Testicular Injury: Chemical/Metal Induced : CK(774) : AC(385)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Cytoprotective : CK(809) : AC(401)
Problem Substances : Aluminum : CK(1075) : AC(356)

Curcumin could be useful to protect the liver from nicotine toxicity.

Pubmed Data : J Tradit Complement Med. 2016 Apr ;6(2):176-83. Epub 2015 Jan 31. PMID: 27114942
Article Published Date : Mar 31, 2016
Authors : Mohammadreza Salahshoor, Sabah Mohamadian, Seyran Kakabaraei, Shiva Roshankhah, Cyrus Jalili
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Nicotine/Tobacco Toxicity : CK(273) : AC(108)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin could inhibit the pro-oxidant effects of gallic acid.

Pubmed Data : Ren Fail. 2015 Dec 27:1-9. Epub 2015 Dec 27. PMID: 26707166
Article Published Date : Dec 26, 2015
Authors : Sunny O Abarikwu, Mojisola Durojaiye, Adenike Alabi, Bede Asonye, Oghenetega Akiri
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Gallic Acid : CK(341) : AC(212)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin could protect against endosulfan induced immunotoxicity in human human peripheral blood mononuclear cells by attenuating apoptosis.

Pubmed Data : Hum Exp Toxicol. 2015 Aug 4. Epub 2015 Aug 4. PMID: 26242398
Article Published Date : Aug 03, 2015
Authors : Tanzeel Ahmed, B D Banerjee
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Pesticide Toxicity : CK(1467) : AC(478)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Antioxidants : CK(34551) : AC(14499), Heat Shock Protein Inducer : CK(156) : AC(57)

Curcumin decreases dibutyl phthalate-induced renal dysfunction in Kunming mice via inhibiting oxidative stress and apoptosis.

Pubmed Data : Hum Exp Toxicol. 2021 Mar 17:9603271211001124. Epub 2021 Mar 17. PMID: 33729022
Article Published Date : Mar 16, 2021
Authors : F Liang, J Xi, X Chen, J Huang, D Jin, X Zhu
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Kidney Damage: Chemically-Induced : CK(561) : AC(281), Phthalate Toxicity : CK(1232) : AC(238)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Antioxidants : CK(34551) : AC(14499), Renoprotective : CK(4544) : AC(1971)
Problem Substances : Phthalates : CK(1705) : AC(331)

Curcumin enriched virgin coconut oil protects against 7,12-dimethyl benz[a] anthracene-induced skin papilloma.

Pubmed Data : Nutr Cancer. 2020 Jun 12:1-8. Epub 2020 Jun 12. PMID: 32530305
Article Published Date : Jun 11, 2020
Authors : Arunaksharan Narayanankutty, Anusree Nair, Soorya Parathodi Illam, Aman Upaganlawar, Achuthan C Raghavamenon
Study Type : Animal Study
Additional Links
Substances : Coconut Oil : CK(478) : AC(106), Curcumin : CK(7239) : AC(3319)
Diseases : Papilloma : CK(10) : AC(5)
Pharmacological Actions : Anticarcinogenic Agents : CK(2152) : AC(1018), Antioxidants : CK(34551) : AC(14499)

Curcumin exerts a protective effect on doxorubicin-induced nephrotic syndrome.

Pubmed Data : J Ethnopharmacol. 2019 Dec 24 ;250:112502. Epub 2019 Dec 24. PMID: 31881321
Article Published Date : Dec 23, 2019
Authors : Hua-Ying Fan, Xue-Kai Wang, Xin Li, Kai Ji, Shi-Hao Du, Yu Liu, Lin-Lin Kong, Jing-Chen Xu, Gang-Qiang Yang, Da-Quan Chen, Dong Qi
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(845) : AC(423)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Chemoprotective Agents : CK(4278) : AC(1621), Heme oxygenase-1 up-regulation : CK(1336) : AC(776), Nrf2 activation : CK(3156) : AC(1794)

Curcumin exerts a stroke preventive effect by attenuating oxidative stress to improve vascular endothelial function.

Pubmed Data : BMC Cardiovasc Disord. 2018 Mar 1 ;18(1):43. Epub 2018 Mar 1. PMID: 29490624
Article Published Date : Feb 28, 2018
Authors : Cong Lan, Xinjian Chen, Yuxun Zhang, Wei Wang, Wei Eric Wang, Yukai Liu, Yue Cai, Hongmei Ren, Shuo Zheng, Lin Zhou, Chunyu Zeng
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Stroke : CK(4410) : AC(773), Stroke: Attenuation/Recovery : CK(998) : AC(156)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin exhibits anti-cataract activity in the diabetic rat lens.

Pubmed Data : Mol Vis. 2005;11:561-8. Epub 2005 Jul 26. PMID: 16088325
Article Published Date : Jan 01, 2005
Authors : P Anil Kumar, P Suryanarayana, P Yadagiri Reddy, G Bhanuprakash Reddy
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cataract : CK(444) : AC(123), Diabetes: Cataract : CK(73) : AC(41)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin exhibits anti-HIV activity.

Pubmed Data : Res Virol. 1998 Jan-Feb;149(1):43-52. PMID: 9561563
Article Published Date : Jan 01, 1998
Authors : S Barthelemy, L Vergnes, M Moynier, D Guyot, S Labidalle, E Bahraoui
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : HIV Infections : CK(1193) : AC(399)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin exhibits cytoprotective properties against shiga toxin.

Pubmed Data : Biochem Biophys Res Commun. 2001 Apr 27;283(1):36-41. PMID: 11322764
Article Published Date : Apr 27, 2001
Authors : A Sood, R Mathew, H Trachtman
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Shigellosis : CK(35) : AC(17)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Apoptotic : CK(9585) : AC(7379), Enzyme Inhibitors : CK(846) : AC(399), Heat Shock Protein Inducer : CK(156) : AC(57)

Curcumin exhibits hepatoprotective properties against selenium toxicity.

Pubmed Data : Indian J Physiol Pharmacol. 2005 Jan;49(1):111-4. PMID: 15881869
Article Published Date : Jan 01, 2005
Authors : S Padmaja, T N Raju
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Selenium : CK(1753) : AC(393)
Diseases : Selenium Toxicity (Selenosis) : CK(2) : AC(1)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Enzyme Inhibitors : CK(846) : AC(399), Hepatoprotective : CK(8989) : AC(3831)

Curcumin has a cytoprotective effect against paracetomol-induced cytotoxicity.

Pubmed Data : Biochem Pharmacol. 1990 Jun 15;39(12):1869-75. PMID: 2353930
Article Published Date : Jun 15, 1990
Authors : I A Donatus, Sardjoko, N P Vermeulen
Study Type : In Vitro Study
Additional Links
Substances : Catechols : CK(23) : AC(19), Curcumin : CK(7239) : AC(3319)
Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Lipid Peroxidation : CK(2057) : AC(806), NSAID-induced toxicity : CK(1142) : AC(429)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Cytoprotective : CK(809) : AC(401)

Curcumin has a detoxifiying and antioxidant effect in rats experimentallly exposed to mercury.

Pubmed Data : Cont Lens Anterior Eye. 2009 Dec 21. Epub 2009 Dec 21. PMID: 20229497
Article Published Date : Dec 21, 2009
Authors : Rakhi Agarwal, Sudhir K Goel, Jai Raj Behari
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Mercury Poisoning : CK(546) : AC(159)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Detoxifier : CK(856) : AC(254)

Curcumin has a protective effect on myocardial ischemia reperfusion injury.

Pubmed Data : Zhong Yao Cai. 2005 Oct;28(10):920-2. PMID: 16479932
Article Published Date : Oct 01, 2005
Authors : Hong Cheng, Weiguan Liu, Xiaomei Ai
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Lipid Peroxidation : CK(2057) : AC(806), Myocardial Ischemia : CK(1001) : AC(460)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963)

Curcumin has an ameliorative effect on chlorpyrifos-induced biochemical changes in Cyprinus carpio.

Pubmed Data : Ecotoxicol Environ Saf. 2018 Apr 30 ;151:49-54. Epub 2018 Jan 3. PMID: 29306070
Article Published Date : Apr 29, 2018
Authors : M Enis Yonar
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Pesticide Toxicity : CK(1467) : AC(478)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)
Problem Substances : Chlorpyrifos : CK(230) : AC(87)

Curcumin has ant-allergic activities.

Pubmed Data : Biol Pharm Bull. 2005 Aug;28(8):1438-43. PMID: 16079489
Article Published Date : Aug 01, 2005
Authors : Makoto Suzuki, Tomonori Nakamura, Sachi Iyoki, Akihiro Fujiwara, Yuhya Watanabe, Kunihiko Mohri, Kimiaki Isobe, Kageyoshi Ono, Shingo Yano
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Allergies : CK(2000) : AC(406)
Pharmacological Actions : Anti-Allergic Agents : CK(598) : AC(221), Antioxidants : CK(34551) : AC(14499)

Curcumin has anti-leukemia properties.

Pubmed Data : J Nat Prod. 2007 Dec;70(12):1884-8. Epub 2007 Dec 13. PMID: 18076140
Article Published Date : Dec 01, 2007
Authors : Miguel López-Lázaro, Elaine Willmore, Andrew Jobson, Kathryn L Gilroy, Hannah Curtis, Kay Padget, Caroline A Austin
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Leukemia : CK(2094) : AC(910)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin has been shown to be very effective against cataract.

Pubmed Data : Pharmacol Rep. 2016 Jan 22 ;68(3):561-569. Epub 2016 Jan 22. PMID: 26894964
Article Published Date : Jan 21, 2016
Authors : Thiagarajan Raman, Manikandan Ramar, Munusamy Arumugam, Seyed Mohammad Nabavi, Mosur Kumaraswamy Nagarajan Sai Varsha
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cataract : CK(444) : AC(123)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Cytoprotective : CK(809) : AC(401)

Curcumin has leishmanicidal activity.

Pubmed Data : Biol Pharm Bull. 2002 Jan;25(1):131-3. PMID: 11824543
Article Published Date : Jan 01, 2002
Authors : Tatsuo Koide, Mitsuhiko Nose, Yuiko Ogihara, Yoshisada Yabu, Nobuo Ohta
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Leishmaniasis : CK(185) : AC(126)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Leishmanicidal : CK(164) : AC(110)

Curcumin has neuroprotective effects in traumatic brain injury models.

Pubmed Data : Curr Neurovasc Res. 2023 Mar 3. Epub 2023 Mar 3. PMID: 36872351
Article Published Date : Mar 02, 2023
Authors : Chen Bing, Shi Quan-Xing, Nie Chuang, Zhao Zhi-Ping, Wang Tao, Zhou Qiang, Gu Jian-Wen
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Brain: Oxidative Stress : CK(644) : AC(347), Brain Inflammation : CK(1784) : AC(928), Traumatic Brain Injury : CK(537) : AC(153)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin has preventive effects on oxidative stress parameters against ischemia-reperfusion injury.

Pubmed Data : Eur Rev Med Pharmacol Sci. 2015 Dec ;19(23):4664-70. PMID: 26698266
Article Published Date : Nov 30, 2015
Authors : Y Yılmaz, K Taken, M Atar, M Ergün, H Söylemez
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Ischemia : CK(626) : AC(325)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin has protective effects against hepatic ischemia/reperfusion injury. Its mechanism might be related to the overexpression of heat shock protein 70 and antioxidant enzymes.

Pubmed Data : World J Gastroenterol. 2007 Apr 7;13(13):1953-61. PMID: 17461496
Article Published Date : Apr 07, 2007
Authors : Shi-Qiang Shen, Yuan Zhang, Jin-Jian Xiang, Cheng-Long Xiong
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Disease : CK(367) : AC(117)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Apoptotic : CK(9585) : AC(7379), Enzyme Inhibitors : CK(846) : AC(399), Heat Shock Protein Inducer : CK(156) : AC(57)
Additional Keywords : Heat Shock Protein Inducer : CK(7) : AC(5)

Curcumin has radioprotective properties.

Pubmed Data : Biophys Chem. 2001 Aug 30;92(1-2):119-26. PMID: 11527584
Article Published Date : Aug 30, 2001
Authors : S Kapoor, K I Priyadarsini
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Radiation Induced Illness : CK(1352) : AC(366)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Radioprotective : CK(2398) : AC(713)

Curcumin improved total antioxidant capacity and lowered PSA scores.

Pubmed Data : Nutr Cancer. 2016 ;68(1):77-85. Epub 2016 Jan 15. PMID: 26771294
Article Published Date : Dec 31, 2015
Authors : Jalal Hejazi, Reza Rastmanesh, Forough-Azam Taleban, Seyed-Hadi Molana, Ehsan Hejazi, Golamreza Ehtejab, Noboru Hara
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Prostate Cancer : CK(2805) : AC(1046)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin improves the ability of donepezil to ameliorate memory impairment.

Pubmed Data : Drug Chem Toxicol. 2022 Sep 7:1-9. Epub 2022 Sep 7. PMID: 36069210
Article Published Date : Sep 06, 2022
Authors : Opeyemi Babatunde Ogunsuyi, Olayemi Philemon Aro, Ganiyu Oboh, Olawande Chinedu Olagoke
Study Type : Insect Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Memory Disorders : CK(2227) : AC(614)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949), Nrf2 activation : CK(3156) : AC(1794)

Curcumin improves the function of umbilical vein endothelial cells.

Pubmed Data : Mol Med Rep. 2022 Jun ;25(6). Epub 2022 May 11. PMID: 35543146
Article Published Date : May 31, 2022
Authors : Yulin Yuan, Caiping Zhang, Yunwu He, Lingzhi Yuan, Qian Zhao, Yuhe Liu, Shiyin Long
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Atherosclerosis : CK(2063) : AC(778), Hydrogen Peroxide Induced Toxicity : CK(437) : AC(349)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin improves the metabolic status in diabetic conditions.

Pubmed Data : Phytother Res. 2007 Apr;21(4):395-7. PMID: 8609907
Article Published Date : Apr 01, 2007
Authors : P S Babu, K Srinivasan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Blood Sugar Problems : CK(20719) : AC(4503), Lipid Peroxidation : CK(2057) : AC(806)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species.

Pubmed Data : Cancer Lett.2006 Jul 28;239(1):144-50. Epub 2005 Nov 21 PMID: 16770527
Article Published Date : Jul 28, 2006
Authors : Manikandan Panchatcharam, Sumitra Miriyala, Vinaya Subramani Gayathri, Lonchin Suguna
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Wound Healing : CK(4555) : AC(1412)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin induces programmed cell death in human promyelocytic leukemia HL-60 cells.

Pubmed Data : Life Sci. 2008 Feb 13;82(7-8):367-75. Epub 2007 Dec 7. PMID: 18187158
Article Published Date : Feb 13, 2008
Authors : Ya-Fan Liao, Hui-Chih Hung, Tzyh-Chyuan Hour, Pei-Chen Hsu, Ming-Ching Kao, Gregory J Tsay, Guang-Yaw Liu
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Leukemia: Acute promyelocytic leukemia : CK(72) : AC(50)
Pharmacological Actions : Anticarcinogenic Agents : CK(2152) : AC(1018), Antioxidants : CK(34551) : AC(14499), Apoptotic : CK(9585) : AC(7379)

Curcumin inhibits human leukemia cells.

Pubmed Data : Biochim Biophys Acta. 1996 Nov 15;1317(2):95-100. PMID: 8950193
Article Published Date : Nov 15, 1996
Authors : M L Kuo, T S Huang, J K Lin
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Promyelocytic leukemia : CK(163) : AC(138)
Pharmacological Actions : Antineoplastic Agents : CK(2235) : AC(1468), Antioxidants : CK(34551) : AC(14499), Apoptotic : CK(9585) : AC(7379), Bcl-2 protein down-regulation : CK(711) : AC(529), Oncogene Suppressor : CK(18) : AC(14)

Curcumin inhibits radiation-impaired healing of excisional wounds in mice.

Pubmed Data : J Wound Care. 2004 Mar;13(3):107-9. PMID: 15045805
Article Published Date : Mar 01, 2004
Authors : G C Jagetia, G K Rajanikant
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Radiation Induced Illness : CK(1352) : AC(366), Wound Healing : CK(4555) : AC(1412)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Radioprotective : CK(2398) : AC(713)

Curcumin inhibits xanthine oxidase.

Pubmed Data : Nutrition. 2006 Jun;22(6):593-9. PMID: 19800788
Article Published Date : Jun 01, 2006
Authors : Liang Shen, Hong-Fang Ji
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Gout : CK(255) : AC(63)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Enzyme Inhibitors : CK(846) : AC(399), Xanthine oxidase inhibitor : CK(91) : AC(49)

Curcumin intervention ameliorates the AFB(1) induced toxicity.

Pubmed Data : J Ethnopharmacol. 2010 Feb 17;127(3):641-4. Epub 2009 Dec 14. PMID: 20015472
Article Published Date : Feb 17, 2010
Authors : Sujatha Nayak, R B Sashidhar
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aflatoxicosis : CK(301) : AC(109), Chemically-Induced Liver Damage : CK(2304) : AC(1089), Liver Damage: Aflatoxin-Induced : CK(104) : AC(48)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Curcumin is a natural product, which can be a therapeutic option in a variety of retinal diseases due to its pleiotropic properties.

Pubmed Data : Antioxidants (Basel). 2020 Jan 6 ;9(1). Epub 2020 Jan 6. PMID: 31935797
Article Published Date : Jan 05, 2020
Authors : Daniel López-Malo, Carlos Alberto Villarón-Casares, Jorge Alarcón-Jiménez, Maria Miranda, Manuel Díaz-Llopis, Francisco J Romero, Vincent M Villar
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetic Retinopathy : CK(483) : AC(211), Glaucoma : CK(611) : AC(145), Macular Degeneration : CK(604) : AC(173), Retinal Diseases : CK(146) : AC(60), Retinitis Pigmentosa : CK(106) : AC(25)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin is a potential glucose-lowering agent and antioxidant in type 2 diabetic mice.

Pubmed Data : Phytother Res. 2008 Feb;22(2):180-4. PMID: 18398869
Article Published Date : Feb 01, 2008
Authors : Kwon-Il Seo, Myung-Sook Choi, Un Ju Jung, Hye-Jin Kim, Jiyoung Yeo, Seon-Min Jeon, Mi-Kyung Lee
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetes Mellitus: Type 2 : CK(12953) : AC(2579), Insulin Resistance : CK(4864) : AC(1098)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hypoglycemic Agents : CK(9221) : AC(2076)

Curcumin is capable of modulating the expression of over 2,000 genes in a cancer cell line simultaneously.

Pubmed Data : Nutr Cancer. 2012 ;64(4):607-16. Epub 2012 Apr 10. PMID: 22489823
Article Published Date : Dec 31, 2011
Authors : Seethalakshmi Sreenivasan, Karthiyaini Thirumalai, Subramanian Krishnakumar
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Retinoblastoma : CK(78) : AC(35)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379), Cell cycle arrest : CK(2120) : AC(1715)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Curcumin lessens unpredictable chronic mild stress-induced depression and memory deficits by modulating oxidative stress and cholinergic activity.

Pubmed Data : Pak J Pharm Sci. 2019 Jul ;32(4(Supplementary)):1893-1900. PMID: 31680089
Article Published Date : Jun 30, 2019
Authors : Fizza Naqvi, Sadia Saleem, Faizan Naqvi, Zehra Batool, Sadia Sadir, Saiqa Tabassum, Saara Ahmed, Laraib Liaquat, Saida Haider
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Anxiety : CK(4246) : AC(759), Anxiety : CK(4246) : AC(759)
Pharmacological Actions : Acetylcholinesterase Inhibitor : CK(259) : AC(128), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin may attenuate diabetic complications.

Pubmed Data : FEBS Lett. 2009 Nov 19;583(22):3637-42. Epub 2009 Oct 20. PMID: 19850041
Article Published Date : Nov 19, 2009
Authors : P Muthenna, P Suryanarayana, Shravan K Gunda, J Mark Petrash, G Bhanuprakash Reddy
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetic Complications : CK(4678) : AC(1606)
Pharmacological Actions : Aldose reductase inhibitor : CK(32) : AC(9), Antioxidants : CK(34551) : AC(14499)

Curcumin may be beneficial in the treatment of acute stress induced anxiety and enhancement of memory function.

Pubmed Data : Brain Res Bull. 2015 Jun ;115:1-8. Epub 2015 Apr 11. PMID: 25869755
Article Published Date : May 31, 2015
Authors : Saida Haider, Fizza Naqvi, Zehra Batool, Saiqa Tabassum, Sadia Sadir, Laraib Liaquat, Faizan Naqvi, Nudrat Anwer Zuberi, Hina Shakeel, Tahira Perveen
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Anxiety Disorders : CK(1558) : AC(241), Brain Inflammation : CK(1784) : AC(928), Stress : CK(1192) : AC(198)
Pharmacological Actions : Anti-Anxiety Agents : CK(4846) : AC(804), Antioxidants : CK(34551) : AC(14499), Malondialdehyde Down-regulation : CK(3028) : AC(992), Superoxide Dismutase Up-regulation : CK(2383) : AC(928)

Curcumin may have a role to play in modulating pathological scar formation.

Pubmed Data : J Cell Mol Med. 2009 Apr;13(4):712-25. Epub 2008 Apr 10. PMID: 18410527
Article Published Date : Apr 01, 2009
Authors : A Scharstuhl, H A M Mutsaers, S W C Pennings, W A Szarek, F G M Russel, F A D T G Wagener
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Scars : CK(226) : AC(59), Wound Healing : CK(4555) : AC(1412)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Apoptotic : CK(9585) : AC(7379)

Curcumin may have therapeutic value in Alzheimer disease prevention.

Pubmed Data : Cancer Lett. 2009 Nov 24. Epub 2009 Nov 24. PMID: 11755008
Article Published Date : Nov 24, 2009
Authors : S A Frautschy, W Hu, P Kim, S A Miller, T Chu, M E Harris-White, G M Cole
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alzheimer's Disease : CK(5355) : AC(2210)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin may have therapeutic value in the treatment of endometriosis.

Pubmed Data : Indian J Biochem Biophys. 2009 Feb;46(1):59-65. PMID: 19374255
Article Published Date : Feb 01, 2009
Authors : Snehasikta Swarnakar, Sumit Paul
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Endometriosis : CK(579) : AC(159)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin may offer potential remedy of gastric antral ulcerations.

Pubmed Data : J Microbiol Biotechnol. 2016 May 20. Epub 2016 May 20. PMID: 27197667
Article Published Date : May 19, 2016
Authors : Jeong-Hwan Kim, Soojung Jin, Hyun Ju Kwon, Byung Woo Kim
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Gastric Ulcer : CK(631) : AC(291), Lipid Peroxidation : CK(2057) : AC(806)
Pharmacological Actions : Anti-Ulcer Agents : CK(1250) : AC(341), Antioxidants : CK(34551) : AC(14499), Gastroprotective : CK(1692) : AC(701)
Problem Substances : Naproxen : CK(68) : AC(10)

Curcumin may play a protective role against oxidative stress in islet transplantation outcomes.

Pubmed Data : Pancreas. 2009 May;38(4):454-60. PMID: 19188863
Article Published Date : May 01, 2009
Authors : A N Balamurugan, Leonid Akhov, Gopalan Selvaraj, Subbiah Pugazhenthi
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Organ Transplantation: Pancreatic Islet Cells : CK(8) : AC(5)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Apoptotic : CK(9585) : AC(7379)

Curcumin may potentially serve as an antioxidant therapy of Pelizaeus-Merzbacher disease caused by PLP1 gene duplication.

Pubmed Data : Ann Clin Transl Neurol. 2015 Aug ;2(8):787-96. Epub 2015 Jun 24. PMID: 26339673
Article Published Date : Jul 31, 2015
Authors : Dirk B Epplen, Thomas Prukop, Tobias Nientiedt, Philipp Albrecht, Friederike A Arlt, Ruth M Stassart, Celia M Kassmann, Axel Methner, Klaus-Armin Nave, Hauke B Werner, Michael W Sereda
Study Type : Transgenic Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Leukodystrophy : CK(4) : AC(2), Pelizaeus-Merzbacher disease (PMD) : CK(2) : AC(1)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin might increase the effect of vitamin C in protecting the function of endothelial cells through its anti-oxidant with hypoglycemic and hypolipidemic actions.

Pubmed Data : Clin Hemorheol Microcirc. 2006;35(4):481-9. PMID: 17148847
Article Published Date : Jan 01, 2006
Authors : Suthiluk Patumraj, Natchaya Wongeakin, Patarin Sridulyakul, Amporn Jariyapongskul, Narisa Futrakul, Srichitra Bunnag
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Vitamin C : CK(6066) : AC(1408)
Diseases : Dyslipidemias : CK(1626) : AC(329), Endothelial Dysfunction : CK(2733) : AC(581)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hypoglycemic Agents : CK(9221) : AC(2076), Hypolipidemic : CK(9173) : AC(2038)
Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

Curcumin mitigates neurotoxic and neurobehavioral changes of gentamicin.

Pubmed Data : Life Sci. 2021 Jan 15 ;265:118824. Epub 2020 Dec 2. PMID: 33278387
Article Published Date : Jan 14, 2021
Authors : Yasmina M Abd-Elhakim, Sabry M Abdel-Motal, Seham M Malhat, Hend I Mostafa, Attia A A Moselhy, Rasha R Beheiry, Enas N Said
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemotherapy-Induced Toxicity: Gentamicin : CK(194) : AC(102)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Antioxidants : CK(34551) : AC(14499), Chemoprotective Agents : CK(4278) : AC(1621), Malondialdehyde Down-regulation : CK(3028) : AC(992), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin potentiates α7 nicotinic acetylcholine receptors and alleviates autistic-like social deficits and brain oxidative stress status.

Pubmed Data : Int J Mol Sci. 2021 Jul 6 ;22(14). Epub 2021 Jul 6. PMID: 34298871
Article Published Date : Jul 05, 2021
Authors : Petrilla Jayaprakash, Dmytro Isaev, Waheed Shabbir, Dietrich E Lorke, Bassem Sadek, Murat Oz
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Autism Spectrum Disorders : CK(3722) : AC(571), Brain: Oxidative Stress : CK(644) : AC(347)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin pre-treatment could reduce the effect of radiation on the skin of patients receiving radiotherapy for the treatment of cancer.

Pubmed Data : Antioxidants (Basel). 2015 ;4(1):25-41. Epub 2015 Jan 13. PMID: 26785336
Article Published Date : Dec 31, 2014
Authors : Ganesh Chandra Jagetia, Golgod Krishnamurthy Rajanikant
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Radiotherapy : CK(219) : AC(53)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Radioprotective : CK(2398) : AC(713), Superoxide Dismutase Up-regulation : CK(2383) : AC(928)

Curcumin pretreatment has a beneficial effect on wound healing in mice whole-body exposed to various doses of gamma-radiation.

Pubmed Data : Chemosphere. 2009 Mar;74(9):1145-51. Epub 2009 Jan 13. PMID: 15172199
Article Published Date : Mar 01, 2009
Authors : Ganesh Chandra Jagetia, G K Rajanikant
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Radiation Induced Illness : CK(1352) : AC(366), Wound Healing : CK(4555) : AC(1412)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Radioprotective : CK(2398) : AC(713)

Curcumin prevents acrylamide-induced DNA damage in liver cells.

Pubmed Data : Wei Sheng Yan Jiu. 2009 Jul;38(4):392-5. PMID: 19689063
Article Published Date : Jul 01, 2009
Authors : Jun Cao, Liping Jiang, Chengyan Geng, Xiaofeng Yao
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Acrylamide-induced toxicity : CK(121) : AC(69), DNA damage : CK(2301) : AC(842)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin prevents cholesterol oxidation, indicating its therapeutic value in attenuating atherosclerosis and lesion formation.

Pubmed Data : Prostaglandins Other Lipid Mediat. 2009 Nov;90(1-2):13-20. Epub 2009 Jun 21. PMID: 19549571
Article Published Date : Nov 01, 2009
Authors : Mohamedain M Mahfouz, Sherry Q Zhou, Fred A Kummerow
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Atherosclerosis : CK(2063) : AC(778), Cholesterol: Oxidation : CK(654) : AC(159)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin prevents chronic intermittent hypoxia-induced myocardial injury.

Pubmed Data : Ther Adv Chronic Dis. 2020 ;11:2040622320922104. Epub 2020 Jun 24. PMID: 32637058
Article Published Date : Dec 31, 2019
Authors : Sophie Moulin, Claire Arnaud, Sophie Bouyon, Jean-Louis Pépin, Diane Godin-Ribuot, Elise Belaidi
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Hypoxia : CK(436) : AC(244)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963), Hypoxia-inducible factor-1 (HIF-1) inhibitor : CK(89) : AC(33)

Curcumin prevents cisplatin-induced chromosomal abberations in rat bone marrow cells.

Pubmed Data : Mutat Res. 2000 Feb 16;465(1-2):131-7. PMID: 10708978
Article Published Date : Feb 16, 2000
Authors : L M Antunes, M C Araújo, J D Darin, M L Bianchi
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemotherapy Induced Myelotoxicity : CK(68) : AC(14), Chemotherapy-Induced Toxicity: Cisplatin : CK(1246) : AC(601)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Genoprotective : CK(522) : AC(203)

Curcumin prevents cisplatin-induced decrease in the tight and adherens junctions: relation to oxidative stress.

Pubmed Data : Food Funct. 2015 Oct 15. Epub 2015 Oct 15. PMID: 26467482
Article Published Date : Oct 14, 2015
Authors : Joyce Trujillo, Eduardo Molina-Jijón, Omar Noel Medina-Campos, Rafael Rodríguez-Muñoz, José Luis Reyes, María L Loredo, Diana Barrera-Oviedo, Enrique Pinzón, Daniela Saraí Rodríguez-Rangel, José Pedraza-Chaverri
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1246) : AC(601)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Chemoprotective Agents : CK(4278) : AC(1621), Renoprotective : CK(4544) : AC(1971)

Curcumin prevents DNA damage associated with benzo[a]pyrene exposure.

Pubmed Data : Mutat Res. 2004 Feb 14;557(2):203-13. PMID: 14729375
Article Published Date : Feb 14, 2004
Authors : K Polasa, A N Naidu, I Ravindranath, K Krishnaswamy
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Benzo[a]pyrene-induced Toxicity : CK(215) : AC(129), DNA damage : CK(2301) : AC(842)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Genoprotective : CK(522) : AC(203)

Curcumin prevents myocardial ischemia in the cat heart.

Pubmed Data : Indian J Med Res. 1995 Jan;101:31-5. PMID: 7883281
Article Published Date : Jan 01, 1995
Authors : M Dikshit, L Rastogi, R Shukla, R C Srimal
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Myocardial Ischemia : CK(1001) : AC(460)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963)
Additional Keywords : Natural Substances Versus Drugs : CK(2806) : AC(560)

Curcumin prevents proteins expression changes of oxidative phosphorylation, cellular stress response, and lipid metabolism proteins in liver of mice fed a high-fructose diet.

Pubmed Data : J Proteomics. 2022 Apr 29 ;263:104595. Epub 2022 Apr 29. PMID: 35490921
Article Published Date : Apr 28, 2022
Authors : Oscar Gerardo Silva-Gaona, Magdalena Hernández-Ortiz, Katya Vargas-Ortiz, Joel Ramírez-Emiliano, Ma Eugenia Garay-Sevilla, Sergio Encarnación-Guevara, Victoriano Pérez-Vázquez
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : High Fructose Diet : CK(474) : AC(187), Liver Damage : CK(4109) : AC(1872)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Hypolipidemic : CK(9173) : AC(2038)

Curcumin prevents radiation-induced mammary tumors.

Pubmed Data : Int J Radiat Oncol Biol Phys. 2002 Jan 1;52(1):212-23. PMID: 11777641
Article Published Date : Jan 01, 2002
Authors : Hiroshi Inano, Makoto Onoda
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Breast Cancer : CK(8297) : AC(3043), Breast Cancer: Prevention : CK(552) : AC(82)
Pharmacological Actions : Anticarcinogenic Agents : CK(2152) : AC(1018), Antineoplastic Agents : CK(2235) : AC(1468), Antioxidants : CK(34551) : AC(14499), Enzyme Inhibitors : CK(846) : AC(399), Radioprotective : CK(2398) : AC(713)

Curcumin prevents radiation-induced thymic lymphoma in mice.

Pubmed Data : J Environ Pathol Toxicol Oncol. 2007;26(4):273-9. PMID: 18197825
Article Published Date : Jan 01, 2007
Authors : P Dange, H Sarma, Badri Narain Pandey, Kaushala Prasad Mishra
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Vitamin C : CK(6066) : AC(1408)
Diseases : Aging : CK(6221) : AC(1510), Lymphoma : CK(430) : AC(168), Radiation Induced Illness : CK(1352) : AC(366)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Chemopreventive : CK(6580) : AC(2166)

Curcumin protects against chemically-induced liver damage in rats.

Pubmed Data : Life Sci. 2006 Apr 4;78(19):2188-93. Epub 2005 Nov 8. PMID: 16288784
Article Published Date : Apr 04, 2006
Authors : Tomomi Sugiyama, Jun-ichi Nagata, Azumi Yamagishi, Kaori Endoh, Morio Saito, Kazuhiko Yamada, Shizuo Yamada, Keizo Umegaki
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin protects against colchicine-induced cognitive dysfunction and oxidative stress in rats.

Pubmed Data : Hum Exp Toxicol. 2012 Jan 19. Epub 2012 Jan 19. PMID: 22262262
Article Published Date : Jan 19, 2012
Authors : S Khurana, S Jain, P K Mediratta, B D Banerjee, K K Sharma
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cognitive dysfunction: colchicine-induced : CK(2) : AC(1)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin protects against cypermethrin-induced oxidative stress in rats.

Pubmed Data : Exp Toxicol Pathol. 2010 Dec 2. Epub 2010 Dec 2. PMID: 21130633
Article Published Date : Dec 02, 2010
Authors : Palanisamy Sankar, Avinash G Telang, Ayyasamy Manimaran
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Pesticide Toxicity : CK(1467) : AC(478), Pesticide Toxicity: Cypermethrin : CK(10) : AC(6)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin protects against doxorubicin (adriamycin)-induced toxicity in rats.

Pubmed Data : J Med Food. 2009 Apr;12(2):394-402. PMID: 19459743
Article Published Date : Apr 01, 2009
Authors : Ragaa Hosny Mohamad, Amal Mohamad El-Bastawesy, Zekry Khalid Zekry, Hussain A Al-Mehdar, Mohamad Gamil Abdel Monaam Al-Said, Soaad Shaker Aly, Sabry Mohamed Sharawy, Mahmuod M El-Merzabani
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Chemotherapy-Induced Toxicity: Doxorubicin : CK(845) : AC(423)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Drug: Doxorubicin : CK(195) : AC(76), Drug Side Effect Attenuation : CK(251) : AC(49), Plant Extracts : CK(18762) : AC(6782)

Curcumin protects against gamma radiation-induced ileal mucosal damage.

Pubmed Data : Arch Toxicol. 2009 Jun;83(6):609-17. Epub 2008 Aug 27. PMID: 18754102
Article Published Date : Jun 01, 2009
Authors : Meryem Akpolat, Mehmet Kanter, Mustafa Cem Uzal
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Radiation Induced Illness : CK(1352) : AC(366), Radiation Induced Illness: Mucositis : CK(348) : AC(44)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Radioprotective : CK(2398) : AC(713)

Curcumin protects against gamma ray induced conformational change of human serum albumin.

Pubmed Data : Int J Biol Macromol. 2017 Jun ;99:600-607. Epub 2017 Mar 6. PMID: 28274864
Article Published Date : May 31, 2017
Authors : Turban Kar, Pijush Basak, Rittik Kumar Ghosh, Maitree Bhattacharyya
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Radiation Induced Illness : CK(1352) : AC(366)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Radioprotective : CK(2398) : AC(713)
Additional Keywords : Antioxidants : CK(303) : AC(126), CURCUMIN : CK(25) : AC(18), CURCUMIN : CK(25) : AC(18), CURCUMIN : CK(25) : AC(18)

Curcumin protects against ischaemia/reperfusion insult in rat forebrain.

Pubmed Data : Pharmacol Res. 2002 Sep;46(3):273-9. PMID: 12220971
Article Published Date : Sep 01, 2002
Authors : Asser I Ghoneim, Ashraf B Abdel-Naim, Amani E Khalifa, Ezzeddin S El-Denshary
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Brain Ischemia : CK(582) : AC(255)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin protects against ischemia/reperfusion injury in rat kidneys.

Pubmed Data : World J Urol. 2008 Jun;26(3):285-91. Epub 2008 Mar 29. PMID: 18373094
Article Published Date : Jun 01, 2008
Authors : Omer Bayrak, Ebru Uz, Reyhan Bayrak, Faruk Turgut, Ali Fuat Atmaca, Semsettin Sahin, Mehmet Erol Yildirim, Arif Kaya, Ersin Cimentepe, Ali Akcay
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Kidney Damage : CK(805) : AC(359)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Enzyme Inhibitors : CK(846) : AC(399), Renoprotective : CK(4544) : AC(1971)

Curcumin protects against isoproterenol induced myocardial infarction in rats.

Pubmed Data : Nutr Cancer. 2001;39(1):148-53. PMID: 8858558
Article Published Date : Jan 01, 2001
Authors : C Nirmala, R Puvanakrishnan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Myocardial Infarction : CK(2132) : AC(509)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963)

Curcumin protects against lipid peroxidation and oxidative stress during nicotine-induced toxicity.

Pubmed Data : Toxicol Mech Methods. 2004;14(6):339-43. PMID: 20021100
Article Published Date : Jan 01, 2004
Authors : C Kalpana, Venugopal P Menon
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Lipid Peroxidation : CK(2057) : AC(806), Nicotine/Tobacco Toxicity : CK(273) : AC(108)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin protects against metal-induced lipid peroxidation and mitigates adverse effects on the antioxidant system.

Pubmed Data : Antioxidants (Basel). 2023 Jan 21 ;12(2). Epub 2023 Jan 21. PMID: 36829803
Article Published Date : Jan 20, 2023
Authors : Elena Smirnova, Mohammad Moniruzzaman, Sungyeon Chin, Anjana Sureshbabu, Adhimoolam Karthikeyan, Kyoungtag Do, Taesun Min
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Metal Toxicity : CK(2667) : AC(1036)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Chelating Agents : CK(48) : AC(25)

Curcumin protects against oxidative and nitrative stress after praziquantel treatment in liver fluke-infected hamsters.

Pubmed Data : Int J Parasitol. 2011 Jan 21. Epub 2011 Jan 21. PMID: 21256849
Article Published Date : Jan 21, 2011
Authors : Lakhanawan Charoensuk, Porntip Pinlaor, Suksanti Prakobwong, Yusuke Hiraku, Umawadee Laothong, Wipaporn Ruangjirachuporn, Puangrat Yongvanit, Somchai Pinlaor
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Drug-Induced Toxicity : CK(562) : AC(83), Parasitic Diseases : CK(140) : AC(72)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin protects against smoke-induced DNA damage.

Pubmed Data : Metabolism. 2002 Jul;51(7):887-92. PMID: 1937145
Article Published Date : Jul 01, 2002
Authors : L Srinivas, V K Shalini
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : DNA damage : CK(2301) : AC(842)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin protects against the age-related hearing loss.

Pubmed Data : Biochem Pharmacol. 2023 Jun ;212:115575. Epub 2023 Apr 30. PMID: 37334787
Article Published Date : May 31, 2023
Authors : Ning Li, Xirui Yan, Weiling Huang, Min Chu, Yang Dong, Haiyan Song, Yinting Peng, Jianrong Shi, Qing Liu
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Hearing Loss : CK(236) : AC(73)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Antioxidants : CK(34551) : AC(14499), Heme oxygenase-1 up-regulation : CK(1336) : AC(776), Nrf2 activation : CK(3156) : AC(1794)

Curcumin protects rat myocardium against isoproterenol-induced ischemic injury.

Pubmed Data : J Cardiovasc Pharmacol. 2010 Apr;55(4):377-84. PMID: 20125031
Article Published Date : Apr 01, 2010
Authors : Vineeta Tanwar, Jaspreet Sachdeva, Mahaveer Golechha, Santosh Kumari, Dharamvir Singh Arya
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Myocardial Ischemia : CK(1001) : AC(460)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963)

Curcumin protects testicle cells of mice from damage induced by chronic alcohol administration.

Pubmed Data : Med Sci Monit. 2008 Nov;14(11):BR237-42. PMID: 18971866
Article Published Date : Nov 01, 2008
Authors : Francesco Giannessi, Maria Anita Giambelluca, Lucia Grasso, Maria Concetta Scavuzzo, Riccardo Ruffoli
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alcohol Toxicity : CK(1235) : AC(480), Infertility: Male : CK(1757) : AC(452), Testicular Diseases : CK(58) : AC(21), Testosterone: Too Low : CK(895) : AC(146)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin reduces burn progression in rats.

Pubmed Data : Acad Emerg Med. 2007 Dec;14(12):1125-9. PMID: 18045885
Article Published Date : Dec 01, 2007
Authors : Adam J Singer, Steve A McClain, Alexander Romanov, Jean Rooney, Tom Zimmerman
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Burns : CK(656) : AC(177)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin reduces high glucose induced neural tube defects by blocking cellular stress and caspase activation.

Pubmed Data : Am J Obstet Gynecol. 2015 Jun ;212(6):802.e1-8. Epub 2015 Jan 13. PMID: 25595578
Article Published Date : May 31, 2015
Authors : Yanqing Wu, Fang Wang, E Albert Reece, Peixin Yang
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetes: Oxidative Stress : CK(635) : AC(244), Diabetic Complications : CK(4678) : AC(1606), Neural Tube Defects : CK(38) : AC(7)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Antioxidants : CK(34551) : AC(14499)

Curcumin reduces oxidative stress associated with exposure to an environmental pollutant.

Pubmed Data : Toxicol Ind Health. 2011 Jan 18. Epub 2011 Jan 18. PMID: 21245202
Article Published Date : Jan 18, 2011
Authors : Osman Ciftci, Ilknur Ozdemir, Sadettin Tanyildizi, Sedat Yildiz, Hakan Oguzturk
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Dioxin Toxicity : CK(27) : AC(11)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin restrains oxidative stress of after intracerebral hemorrhage.

Pubmed Data : Front Pharmacol. 2022 ;13:889226. Epub 2022 Apr 27. PMID: 35571134
Article Published Date : Dec 31, 2021
Authors : Chenyang Duan, Hanbin Wang, Dian Jiao, Yanqin Geng, Qiaoli Wu, Hua Yan, Chunhui Li
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Intracerebral Hemorrhage : CK(292) : AC(54)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Heme oxygenase-1 up-regulation : CK(1336) : AC(776), Neuroprotective Agents : CK(20061) : AC(7949), Nrf2 activation : CK(3156) : AC(1794)

Curcumin seems to be an efficient reducer of oxidative stress related complications in patients with PCOS.

Pubmed Data : Diabetes Metab Syndr. 2020 Jan 8 ;14(2):77-82. Epub 2020 Jan 8. PMID: 31991296
Article Published Date : Jan 07, 2020
Authors : Javad Heshmati, Fereshteh Golab, Mojgan Morvaridzadeh, Eric Potter, Maryam Akbari-Fakhrabadi, Farnaz Farsi, Sara Tanbakooei, Farzad Shidfar
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Polycystic Ovary Syndrome : CK(2116) : AC(332)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), SIRT1 Activator : CK(382) : AC(190), Superoxide Dismutase Up-regulation : CK(2383) : AC(928)

Curcumin supplementation could ameliorate cognitive deficits and reverse biochemical alterations in a ICV-streptozotocin Alzheimer's rat model.

Pubmed Data : Eur J Pharmacol. 2016 Jan 5 ;770:52-60. Epub 2015 Dec 2. PMID: 26638997
Article Published Date : Jan 04, 2016
Authors : Doaa M Samy, Cherine A Ismail, Rasha A Nassra, Teshreen M Zeitoun, Azhar M Nomair
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alzheimer's Disease : CK(5355) : AC(2210), Brain: Oxidative Stress : CK(644) : AC(347), Diabetes Mellitus: Type 2 : CK(12953) : AC(2579)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin supplementation could improve diabetes-induced endothelial dysfunction.

Pubmed Data : BMC Complement Altern Med. 2010;10:57. Epub 2010 Oct 14. PMID: 20946622
Article Published Date : Jan 01, 2010
Authors : Sirada Rungseesantivanon, Naris Thenchaisri, Preecha Ruangvejvorachai, Suthiluk Patumraj
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetes: Cardiovascular Illness : CK(744) : AC(133), Endothelial Dysfunction : CK(2733) : AC(581)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Curcumin suppresses the lipid accumulation and oxidative stress induced by benzo[a]pyrene toxicity in HepG2 cells.

Pubmed Data : Antioxidants (Basel). 2021 Aug 20 ;10(8). Epub 2021 Aug 20. PMID: 34439562
Article Published Date : Aug 19, 2021
Authors : Seung-Cheol Lee, Seung-Cheol Jee, Min Kim, Soee Kim, Min Kyoung Shin, Yunkyung Kim, Jung-Suk Sung
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Benzo[a]pyrene-induced Toxicity : CK(215) : AC(129)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Detoxifier : CK(856) : AC(254)
Problem Substances : Benzo(a)pyrene : CK(184) : AC(108)

Curcumin treatment has a protective effect against intestinal damage induced by bile duct ligation.

Pubmed Data : J Invest Surg. 2015 Dec 18:1-9. Epub 2015 Dec 18. PMID: 26682581
Article Published Date : Dec 17, 2015
Authors : Mehmet Kanter, Mumtaz Takir, Hasan Huseyin Mutlu, Betul Kanter, Osman Kostek, Aybala Erek Toprak
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cholestasis : CK(163) : AC(53)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Antioxidants : CK(34551) : AC(14499), Gastroprotective : CK(1692) : AC(701)

Curcumin works synergistically with antifungal drugs.

Pubmed Data : FEMS Yeast Res. 2010 Aug 1;10(5):570-8. Epub 2010 Apr 23. PMID: 20528949
Article Published Date : Aug 01, 2010
Authors : Monika Sharma, Raman Manoharlal, Arvind Singh Negi, Rajendra Prasad
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Flavonoids : CK(4698) : AC(2176), Polyphenols : CK(2736) : AC(1003), Vitamin C : CK(6066) : AC(1408)
Diseases : Candida Infection : CK(507) : AC(232)
Pharmacological Actions : Antifungal Agents : CK(730) : AC(422), Antioxidants : CK(34551) : AC(14499), Apoptotic : CK(9585) : AC(7379)
Additional Keywords : Drug Synergy : CK(389) : AC(174)

Curcumin works synergistically with erythropoietin to stimulate liver regeneration.

Pubmed Data : Langenbecks Arch Surg. 2008 May;393(3):325-32. Epub 2008 Feb 27. PMID: 18301913
Article Published Date : May 01, 2008
Authors : Daniel Seehofer, Ulf P Neumann, Anja Schirmeier, Jessica Carter, Si-Young Ria Cho, Andri Lederer, Nada Rayes, Michael D Menger, Andreas K Nüssler, Peter Neuhaus
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Disease : CK(367) : AC(117)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Antiproliferative : CK(10001) : AC(7491)
Additional Keywords : Drug Synergy : CK(389) : AC(174), Liver Regeneration : CK(103) : AC(44)

Curcumin works synergistically with insulin on muscle cell glucose metabolism.

Pubmed Data : Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2366-73. Epub 2010 Jun 1. PMID: 20561944
Article Published Date : Aug 01, 2010
Authors : Changkeun Kang, Euikyung Kim
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetes Insipidus : CK(45) : AC(6), Diabetes Mellitus: Type 2 : CK(12953) : AC(2579), Insulin Resistance : CK(4864) : AC(1098)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hypoglycemic Agents : CK(9221) : AC(2076)
Additional Keywords : Drug Synergy : CK(389) : AC(174)

Curcumin's neuroprotective properties may be due to its anticholinesterase, antioxidant activity and brain insulin receptor modulating activities.

Pubmed Data : Pharmacol Res. 2010 Mar;61(3):247-52. Epub 2009 Dec 21. PMID: 20026275
Article Published Date : Mar 01, 2010
Authors : Rahul Agrawal, Bhanvi Mishra, Ethika Tyagi, Chandishwar Nath, Rakesh Shukla
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Dementia : CK(2211) : AC(386), Memory Disorders : CK(2227) : AC(614)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Cholinesterase Inhibitors : CK(38) : AC(28), Insulin Receptor Modulator : CK(12) : AC(2)

Curcumin, an antioxidant and anti-inflammatory agent protects endothelial cells against oxidative stress.

Pubmed Data : Biol Pharm Bull. 2006 Apr;29(4):670-4. PMID: 10889462
Article Published Date : Apr 01, 2006
Authors : R Motterlini, R Foresti, R Bassi, C J Green
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Endothelial Dysfunction : CK(2733) : AC(581), Hypoxia : CK(436) : AC(244)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin, capsaicin, and garlic have a beneficial effect in the red blood cells and liver of cholesterol fed rats.

Pubmed Data : Acta Pharmacol Sin. 2007 Oct;28(10):1559-65. PMID: 15296079
Article Published Date : Oct 01, 2007
Authors : R K Kempaiah, K Srinivasan
Study Type : Animal Study
Additional Links
Substances : Capsaicin : CK(338) : AC(129), Curcumin : CK(7239) : AC(3319), Garlic : CK(2194) : AC(727)
Diseases : High Cholesterol : CK(3091) : AC(530)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963), Hepatoprotective : CK(8989) : AC(3831)

Curcumin, resveratrol and EGCG may have a therapeutic role in proliferative vitreoretinopathy (PVR).

Pubmed Data : Curr Eye Res. 2010 Nov;35(11):1021-33. PMID: 20958191
Article Published Date : Nov 01, 2010
Authors : Anne F Alex, Manfred Spitznas, André P Tittel, Christian Kurts, Nicole Eter
Study Type : In Vitro Study
Additional Links
Substances : Catechin : CK(965) : AC(313), Curcumin : CK(7239) : AC(3319), Resveratrol : CK(3228) : AC(1513)
Diseases : Eye Diseases: Vitreous Disorders : CK(12) : AC(3), Proliferative Vitreoretinopathy (PVR) : CK(6) : AC(5)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379)
Additional Keywords : Stilbenes : CK(406) : AC(244)

Curcumin, resveratrol and vanillin protects against DNA damage.

Pubmed Data : Minerva Med. 1988 May;79(5):387-90. PMID: 12561251
Article Published Date : May 01, 1988
Authors : Guo-An Liu, Rong-Liang Zheng
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Flavonoids : CK(4698) : AC(2176), Polyphenols : CK(2736) : AC(1003), Resveratrol : CK(3228) : AC(1513), Vanillin : CK(90) : AC(54)
Diseases : DNA damage : CK(2301) : AC(842)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Genoprotective : CK(522) : AC(203)

Curcumin-free turmeric extract inhibits chemically-induced gastric tumors in mice.

Pubmed Data : Cancer Lett. 1997 Sep 16;118(1):79-85. PMID: 9310263
Article Published Date : Sep 16, 1997
Authors : S S Deshpande, A D Ingle, G B Maru
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Benzo[a]pyrene-induced Toxicity : CK(215) : AC(129), Gastric Cancer : CK(1619) : AC(725)
Pharmacological Actions : Anticarcinogenic Agents : CK(2152) : AC(1018), Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782), Turmeric Versus Curcumin : CK(4) : AC(2)

Curcumin-loaded nanocapsules reverses the depressant-like behaviour and oxidative stress induced by β-amyloid.

Pubmed Data : Neuroscience. 2019 12 15 ;423:122-130. Epub 2019 Nov 4. PMID: 31698022
Article Published Date : Jan 14, 2019
Authors : Eduarda Monteiro Fidelis, Anne Suély Pinto Savall, Edina da Luz Abreu, Felipe Carvalho, Flávia Elizabete Guerra Teixeira, Sandra Elisa Haas, Tuane Bazanella Sampaio, Simone Pinton
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alzheimer's Disease : CK(5355) : AC(2210), Brain: Oxidative Stress : CK(644) : AC(347), Depression : CK(9574) : AC(1756)
Pharmacological Actions : Antidepressive Agents : CK(7908) : AC(1466), Antioxidants : CK(34551) : AC(14499), Catalase Up-Regulation : CK(403) : AC(165), Superoxide Dismutase Up-regulation : CK(2383) : AC(928)

Curcumin-loaded zein and shellac composite nanoparticles for ulcerative colitis treatment.

Pubmed Data : Eur J Pharm Biopharm. 2025 Apr ;209:114658. Epub 2025 Feb 4. PMID: 39914574
Article Published Date : Mar 31, 2025
Authors : Xiaoyan Mu, Hemin Roghzai, Lingwen Zeng, Xiaoqiang Sun, Xiubo Zhao
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Ulcerative Colitis : CK(1411) : AC(447)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcumin: a natural organic component that plays a multi-faceted role in ovarian cancer.

Pubmed Data : J Ovarian Res. 2023 Mar 1 ;16(1):47. Epub 2023 Mar 1. PMID: 36859398
Article Published Date : Feb 28, 2023
Authors : Xiaoping Liu, Mingming Qi, Xidie Li, Jingjin Wang, Mingyuan Wang
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Ovarian Cancer : CK(1029) : AC(509)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Apoptotic : CK(9585) : AC(7379)

Curcuminoid-piperine combination improves radical scavenging activity in women with premenstrual syndrome and dysmenorrhea.

Pubmed Data : Chonnam Med J. 2024 May ;60(2):113-119. Epub 2024 May 24. PMID: 38841613
Article Published Date : Apr 30, 2024
Authors : Samira Karbasi, Saman Seyedabadi, Samira Mozaffari, Zahra Foroutan, Gordon A Ferns, Asghar Zarban, Afsane Bahrami
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Piperine : CK(600) : AC(258)
Diseases : Dysmenorrhea : CK(1027) : AC(109), Premenstrual syndrome : CK(507) : AC(55)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Curcuminoids protect against neuronal cell death in an Alzheimer disease model.

Pubmed Data : Neurosci Lett. 2001 Apr 27;303(1):57-61. PMID: 11297823
Article Published Date : Apr 27, 2001
Authors : D S Kim, S Y Park, J K Kim
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alzheimer's Disease : CK(5355) : AC(2210)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Dietary curcumin and capsaicin have hypolipidemic and antioxidant effects.

Pubmed Data : Life Sci. 2001 Dec 7;70(3):253-67. PMID: 17960446
Article Published Date : Dec 07, 2001
Authors : H Manjunatha, K Srinivasan
Study Type : Animal Study
Additional Links
Substances : Capsaicin : CK(338) : AC(129), Curcumin : CK(7239) : AC(3319)
Diseases : High Cholesterol : CK(3091) : AC(530)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hypolipidemic : CK(9173) : AC(2038)

Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice.

Pubmed Data : Radiat Res. 2010 May;173(5):590-601. PMID: 20426658
Article Published Date : May 01, 2010
Authors : James C Lee, Paul A Kinniry, Evguenia Arguiri, Matthew Serota, Stathis Kanterakis, Shampa Chatterjee, Charalambos C Solomides, Prashanthi Javvadi, Constantinos Koumenis, Keith A Cengel, Melpo Christofidou-Solomidou
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Lung Cancer : CK(3063) : AC(1429), Pulmonary Fibrosis : CK(379) : AC(149), Radiation Induced Illness : CK(1352) : AC(366)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Radioprotective : CK(2398) : AC(713)

Effects of curcumin on low-density lipoprotein oxidation: From experimental studies to clinical practice.

Pubmed Data : EXCLI J. 2022 ;21:840-851. Epub 2022 Jun 22. PMID: 36110563
Article Published Date : Dec 31, 2021
Authors : Fatemeh Baratzadeh, Alexandra E Butler, Prashant Kesharwani, Seyed Adel Moallem, Amirhossein Sahebkar
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Atherosclerosis : CK(2063) : AC(778)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hypolipidemic : CK(9173) : AC(2038)

Enhanced anticancer efficiency of curcumin co-loaded lawsone solid lipid nanoparticles against MCF-7 breast cancer cell lines.

Pubmed Data : Assay Drug Dev Technol. 2025 Jan 27. Epub 2025 Jan 27. PMID: 39869018
Article Published Date : Jan 26, 2025
Authors : Shivarani Penugonda, Pranusha Beesappagari, Maddileti Repollu, Poojitha Badiginchala, Samreen Qudsiya, Chinni Usha Sree Mala, Ravi Gundawar, Bhargav Eranti
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Breast Cancer : CK(8297) : AC(3043)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Evaluation of the hepatoprotective effects of curcumin and nanocurcumin against paraquat-induced liver injury.

Pubmed Data : J Biochem Mol Toxicol. 2021 Feb 5:e22739. Epub 2021 Feb 5. PMID: 33544450
Article Published Date : Feb 04, 2021
Authors : Nejat Kheiripour, Alireza Plarak, Ali Heshmati, Sara Soleimani Asl, Fereshteh Mehri, Alireza Ebadollahi-Natanzi, Akram Ranjbar, Asieh Hosseini
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Pesticide Toxicity : CK(1467) : AC(478)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Heme oxygenase-1 up-regulation : CK(1336) : AC(776), Hepatoprotective : CK(8989) : AC(3831), Nrf2 activation : CK(3156) : AC(1794)
Problem Substances : Paraquat : CK(190) : AC(94)

Herbal antioxidants in dialysis patients: a review of potential mechanisms and medical implications.

Pubmed Data : Ren Fail. 2021 Dec ;43(1):351-361. PMID: 33593237
Article Published Date : Nov 30, 2021
Authors : Masoumeh Asgharpour, Amirhesam Alirezaei
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Emodin : CK(405) : AC(258), Quercetin : CK(1876) : AC(855), Resveratrol : CK(3228) : AC(1513), Silymarin : CK(455) : AC(112)
Diseases : Chronic Kidney Disease (CKD) : CK(1186) : AC(211)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

How can nanomicelle-curcumin modulate aluminum phosphide-induced neurotoxicity?: Role of SIRT1/FOXO3 signaling pathway.

Pubmed Data : AIMS Neurosci. 2023 ;10(1):56-74. Epub 2023 Apr 4. PMID: 37077959
Article Published Date : Dec 31, 2022
Authors : Milad Khodavysi, Nejat Kheiripour, Hassan Ghasemi, Sara Soleimani-Asl, Ali Fathi Jouzdani, Mohammadmahdi Sabahi, Zahra Ganji, Zahra Azizi, Akram Ranjbar
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aluminum Toxicity : CK(735) : AC(318)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)
Problem Substances : Aluminum : CK(1075) : AC(356)

Improvement of sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by curcumin: results of a randomised, double-blind, placebo-controlled trial.

Pubmed Data : Br J Nutr. 2012 Oct ;108(7):1272-9. Epub 2011 Nov 18. PMID: 22099425
Article Published Date : Sep 30, 2012
Authors : Yunes Panahi, Amirhossein Sahebkar, Mojtaba Amiri, Seyyed Masoud Davoudi, Fatemeh Beiraghdar, Seyyedeh Leila Hoseininejad, Marjan Kolivand
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemical Weapon Agent Injury: Sulfur Mustard : CK(62) : AC(8), Pruritus : CK(114) : AC(20)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)
Problem Substances : Mustard Gas : CK(51) : AC(6)

Liposomal curcumin enhances the effect of naproxen in a model of migraine.

Pubmed Data : Med Sci Monit. 2019 Jul 9 ;25:5087-5097. Epub 2019 Jul 9. PMID: 31287810
Article Published Date : Jul 08, 2019
Authors : Adriana E Bulboacă, Sorana D Bolboacă, Angelo C Bulboacă, Alina S Porfire, Lucia R Tefas, Șoimița M Suciu, Gabriela Dogaru, Ioana C Stănescu
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Headache: Migraine : CK(1018) : AC(130)
Pharmacological Actions : Antinoceceptive : CK(959) : AC(291), Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Liposomal Curcumin : CK(22) : AC(11)

Liposomal curcumin is better than curcumin to alleviate complications in experimental diabetic mellitus.

Pubmed Data : Molecules. 2019 Feb 27 ;24(5). Epub 2019 Feb 27. PMID: 30818888
Article Published Date : Feb 26, 2019
Authors : Adriana Elena Bulboacă, Alina S Porfire, Lucia R Tefas, Paul Mihai Boarescu, Sorana D Bolboacă, Ioana C Stănescu, Angelo Corneliu Bulboacă, Gabriela Dogaru
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetes: Oxidative Stress : CK(635) : AC(244), Diabetic Complications : CK(4678) : AC(1606)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Hypoglycemic Agents : CK(9221) : AC(2076)

Melatonin and curcumin protect against ndomethacin-induced acute gastric ulceration.

Pubmed Data : Free Radic Biol Med. 2006 Sep 15;41(6):911-25. Epub 2006 Apr 30. PMID: 16934674
Article Published Date : Sep 15, 2006
Authors : Krishnendu Ganguly, Parag Kundu, Aditi Banerjee, Russel J Reiter, Snehasikta Swarnakar
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Melatonin : CK(2891) : AC(911)
Diseases : Drug-Induced Toxicity: Indomethacin : CK(78) : AC(40), Gastric Ulcer : CK(631) : AC(291)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Gastroprotective : CK(1692) : AC(701), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(944) : AC(588)
Additional Keywords : Drug: Indomethacin : CK(67) : AC(33)

Melatonin may increase cell survival in the hippocampus via decreasing oxidative stress and SIRT2 expression and increasing Bcl-2 expression.

Pubmed Data : Brain Res Bull. 2018 Jan 8 ;137:306-310. Epub 2018 Jan 8. PMID: 29325994
Article Published Date : Jan 07, 2018
Authors : Arzu Keskin-Aktan, Kazime Gonca Akbulut, Çiğdem Yazici-Mutlu, Gizem Sonugur, Müge Ocal, Hakan Akbulut
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Melatonin : CK(2891) : AC(911)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

NAC and curcumin ameliorate pesticide-induced oxidative DNA damage in human peripheral blood mononuclear cells.

Pubmed Data : Environ Monit Assess. 2010 Nov 4. Epub 2010 Nov 4. PMID: 21049288
Article Published Date : Nov 04, 2010
Authors : Tanzeel Ahmed, Rahul Pathak, Md Mustafa, Rajarshi Kar, Ashok K Tripathi, Rafat S Ahmed, B D Banerjee
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), NAC (N-acetyl-L-cysteine) : CK(1429) : AC(366)
Diseases : DNA damage : CK(2301) : AC(842), Pesticide Toxicity : CK(1467) : AC(478)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Neuroprotective effects of mitochondria-targeted curcumin against rotenone-induced oxidative damage in cerebellum.

Pubmed Data : J Biochem Mol Toxicol. 2020 Jan ;34(1):e22416. Epub 2019 Nov 12. PMID: 31714633
Article Published Date : Dec 31, 2019
Authors : Whidul Hasan, Rajesh Kumar Kori, Juli Jain, Rajesh Singh Yadav, Deepali Jat
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Brain: Oxidative Stress : CK(644) : AC(347)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949), Superoxide Dismutase Up-regulation : CK(2383) : AC(928)
Problem Substances : Rotenone : CK(57) : AC(32)

Obtained findings suggest that curcumin may attenuate the MSG-induced apoptosis.

Pubmed Data : Gen Physiol Biophys. 2018 May ;37(3):329-336. PMID: 29938678
Article Published Date : Apr 30, 2018
Authors : Miodrag Vucic, Irena Cojbasic, Jelena Vucic, Voja Pavlovic
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Antioxidants : CK(34551) : AC(14499)
Problem Substances : Monosodium Glutamate (MSG) : CK(265) : AC(107)

Oral administration of curcumin could effectively stabilize artesunate-induced testicular dysfunction.

Pubmed Data : Dose Response. 2015 Apr-Jun;13(2):1559325815592393. Epub 2015 Jun 26. PMID: 26673878
Article Published Date : Mar 31, 2015
Authors : Ketaki R Desai, Dhrupadsinh K Rajput, Pragnesh B Patel, Hyacinth N Highland
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Anti-Malarial Drug Toxicity : CK(7) : AC(4)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Superoxide Dismutase Up-regulation : CK(2383) : AC(928)

Oral curcumin positively modulates blood lipid levels and lipid peroxidation.

Pubmed Data : Indian J Physiol Pharmacol. 1992 Oct;36(4):273-5. PMID: 1291482
Article Published Date : Oct 01, 1992
Authors : K B Soni, R Kuttan
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cholesterol: High : CK(1726) : AC(267), HDL: Low : CK(305) : AC(50), Lipid Peroxidation : CK(2057) : AC(806)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hypolipidemic : CK(9173) : AC(2038)

Pectic polysaccharides of Momordica charantia in combination with curcumin had liver protective effects.

Pubmed Data : Biochem Biophys Rep. 2017 Sep ;11:64-71. Epub 2017 Jun 23. PMID: 28955769
Article Published Date : Aug 31, 2017
Authors : Hasina Perveen, Moumita Dash, Shamima Khatun, Moulima Maity, Syed Sirajul Islam, Sandip Chattopadhyay
Study Type : In Vitro Study
Additional Links
Substances : Bitter Melon : CK(411) : AC(166), Curcumin : CK(7239) : AC(3319)
Diseases : Arsenic Poisoning : CK(383) : AC(129)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Cytoprotective : CK(809) : AC(401)
Additional Keywords : Polysaccharides : CK(1326) : AC(748)
Problem Substances : Arsenic : CK(608) : AC(184)

Prophylactic use of curcumin may effectively rescue pancreatic islets from damage without affecting the normal function of these cellular structures.

Pubmed Data : BJU Int. 2002 Jun;89(9):829-34. PMID: 17900558
Article Published Date : Jun 01, 2002
Authors : Kanitkar Meghana, Galande Sanjeev, Bhonde Ramesh
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetes Mellitus: Type 1 : CK(2032) : AC(611)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Beta Cell Protection : CK(61) : AC(25)

Protective and anti-oxidative effects of curcumin and resveratrol on Aβ-oligomer-induced damage in the SH-SY5Y cell line.

Pubmed Data : J Neurol Sci. 2022 Aug 1 ;441:120356. Epub 2022 Aug 1. PMID: 35963200
Article Published Date : Jul 31, 2022
Authors : Haibo Yu, Toru Yamashita, Xiao Hu, Zhihong Bian, Xinrang Hu, Tian Feng, Koh Tadokoro, Ryuta Morihara, Koji Abe
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Resveratrol : CK(3228) : AC(1513)
Diseases : Alzheimer's Disease : CK(5355) : AC(2210)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

Protective effect and mechanism of curcumin on aorta in rats with metabolic syndrome

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2019 Nov ;44(21):4685-4690. PMID: 31872665
Article Published Date : Oct 31, 2019
Authors : Li-Jie Yan, Shun-Bao Wang, Xian-Qing Wang, Xue-Ming Cao
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Metabolic Diseases : CK(1273) : AC(272)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Protective effect of Curcuma extract in an ex vivo model of retinal degeneration.

Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:8923615. Epub 2022 Jul 29. PMID: 35941902
Article Published Date : Dec 31, 2021
Authors : Kambiz Hassanzadeh, Zakaria Vahabzadeh, Lucia Bucarello, Jessica Dragotto, Massimo Corbo, Rita Maccarone, Marco Feligioni
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Retinal Diseases : CK(146) : AC(60)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Protective effects of curcumin and its analogues via the Nrf2 pathway in metabolic syndrome.

Pubmed Data : Curr Med Chem. 2023 May 10. Epub 2023 May 10. PMID: 37218198
Article Published Date : May 09, 2023
Authors : Shahnaz Rajabi, Majid Darroudi, Kobra Naseri, Tahereh Farkhondeh, Saeed Samarghandian
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Metabolic Syndrome X : CK(3095) : AC(546)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Nrf2 activation : CK(3156) : AC(1794)

Protective Effects of Curcumin in Cardiovascular Diseases-Impact on Oxidative Stress and Mitochondria.

Pubmed Data : Cells. 2022 01 20 ;11(3). Epub 2022 Jan 20. PMID: 35159155
Article Published Date : Jan 19, 2022
Authors : Fiona Frederike Cox, Angelina Misiou, Annika Vierkant, Niloofar Ale-Agha, Maria Grandoch, Judith Haendeler, Joachim Altschmied
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cardiovascular Diseases : CK(17333) : AC(2878)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963)

Review: Curcumin may have therapeutic value in obesity.

Pubmed Data : Pediatr Rehabil. 2004 Oct-Dec;7(4):245-60. PMID: 21091916
Article Published Date : Oct 01, 2004
Authors : Lini Alappat, Atif B Awad
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Obesity : CK(11004) : AC(2672)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Role of nano curcumin on superoxide dismutase levels in leukoplakia.

Pubmed Data : J Oral Maxillofac Pathol. 2022 Jan-Mar;26(1):21-25. Epub 2022 Mar 31. PMID: 35571299
Article Published Date : Dec 31, 2021
Authors : Sunanda Deb, Deepak Bhargava, Puja Bansal, Vijay Kanuru
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Leukoplakia : CK(121) : AC(19)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Superoxide Dismutase Up-regulation : CK(2383) : AC(928)

Rosemary/carnosic acid, alone or combined with curcumin, may be useful to prevent and treat ER-negative breast cancer.

Pubmed Data : Fitoterapia. 2012 Oct ;83(7):1160-8. Epub 2012 Jul 22. PMID: 22828666
Article Published Date : Sep 30, 2012
Authors : Linda Saxe Einbond, Hsan-Au Wu, Ryota Kashiwazaki, Kan He, Marc Roller, Tao Su, Xiaomei Wang, Sarah Goldsberry
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid : CK(167) : AC(112), Curcumin : CK(7239) : AC(3319), Rosemary : CK(555) : AC(211)
Diseases : Breast Cancer: Triple Negative : CK(970) : AC(659)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379), Cell cycle arrest : CK(2120) : AC(1715)
Additional Keywords : Gene Expression Regulation : CK(1401) : AC(623), Natural Substance Synergy : CK(1400) : AC(669), Plant Extracts : CK(18762) : AC(6782)

Study on the mechanism of curcumin regulating lung injury induced by outdoor fine particulate matter.

Pubmed Data : Mediators Inflamm. 2019 ;2019:8613523. Epub 2019 Aug 21. PMID: 31530996
Article Published Date : Dec 31, 2018
Authors : Kunlun Huang, ChanMei Shi, JingQi Min, Laifu Li, Tao Zhu, Huapeng Yu, Huojin Deng
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Air Pollution Linked Toxicity : CK(4976) : AC(742)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Heme oxygenase-1 up-regulation : CK(1336) : AC(776)

Synergistic antioxidant and antibacterial activity of curcumin-C3 encapsulated chitosan nanoparticles.

Pubmed Data : Curr Pharm Des. 2020 Jun 9. Epub 2020 Jun 9. PMID: 32516096
Article Published Date : Jun 08, 2020
Authors : Desu Naveen Kumar Reddy, Fu-Yung Huang, Shao-Pin Wang, Ramya Kumar
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Escherichia coli Infections : CK(603) : AC(450), Staphylococcus aureus infection : CK(776) : AC(576)
Pharmacological Actions : Anti-Bacterial Agents : CK(4228) : AC(1989), Antioxidants : CK(34551) : AC(14499)

The application of curcumin may be a novel strategy to protect against age-related change in AMD.

Pubmed Data : Drug Des Devel Ther. 2015;9:5337-5344. Epub 2015 Sep 25. PMID: 26445530
Article Published Date : Dec 31, 2014
Authors : Wei Zhu, Yan Wu, Yi-Fang Meng, Jin-Yu Wang, Ming Xu, Jian-Jun Tao, Jiong Lu
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Macular Degeneration : CK(604) : AC(173)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Antioxidants : CK(34551) : AC(14499)

The combination of curcumin and quercetin appears to reduce the number and size of ileal and rectal adenomas in patients with Familialadenomatous polyposis without appreciable toxicity.

Pubmed Data : Clin Gastroenterol Hepatol. 2006 Aug;4(8):1035-8. Epub 2006 Jun 6. PMID: 16757216
Article Published Date : Aug 01, 2006
Authors : Marcia Cruz-Correa, Daniel A Shoskes, Patricia Sanchez, Rhongua Zhao, Linda M Hylind, Steven D Wexner, Francis M Giardiello
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Quercetin : CK(1876) : AC(855)
Diseases : Colon Polyps : CK(110) : AC(23), Colorectal Cancer : CK(4889) : AC(2276), Familial Adenomatous Polyposis : CK(24) : AC(4), Gastrointestinal polyps : CK(34) : AC(6)
Pharmacological Actions : Antineoplastic Agents : CK(2235) : AC(1468), Antioxidants : CK(34551) : AC(14499)

The combination of hyaluronic acid, chondroitin sulfate, curcumin and quercetin was effective in preventing recurrent urinary tract infections.

Pubmed Data : Eur J Obstet Gynecol Reprod Biol. 2016 Dec ;207:125-128. Epub 2016 Nov 1. PMID: 27838537
Article Published Date : Nov 30, 2016
Authors : M Torella, F Del Deo, A Grimaldi, S A Iervolino, M Pezzella, C Tammaro, P Gallo, C Rappa, P De Franciscis, N Colacurci
Study Type : Human Study
Additional Links
Substances : Chondroitin Sulfate : CK(70) : AC(18), Curcumin : CK(7239) : AC(3319), Hyaluronic Acid : CK(249) : AC(39), Quercetin : CK(1876) : AC(855)
Diseases : Aging : CK(6221) : AC(1510), Urinary Tract Infections : CK(655) : AC(91)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Risk Reduction : CK(17935) : AC(2006)

The influence of separate and combined supplementation with curcumin and quercetin on the protective capacity in rats.

Pubmed Data : Vopr Pitan. 2017 ;86(2):14-22. Epub 2017 Feb 27. PMID: 30645874
Article Published Date : Dec 31, 2016
Authors : A S Balakina, I V Aksenov, N V Trusov, G V Guseva, L I Avrenyeva, L V Kravchenko, V A Tutelyan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Quercetin : CK(1876) : AC(855)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Heme oxygenase-1 up-regulation : CK(1336) : AC(776), Nrf2 activation : CK(3156) : AC(1794)
Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

The joint use of doxorubicin and curcumin resulted in a significant reduction of free radical oxidation.

Pubmed Data : Fiziol Zh. 2015 ;61(5):90-8. PMID: 26845849
Article Published Date : Dec 31, 2014
Authors : O Linnik, T Drevytska, O Gonchar, S Chornyi, A Kovalyov, I Mankovska
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(845) : AC(423)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Chemoprotective Agents : CK(4278) : AC(1621)

The mixture of quercetin and curcuminoids at a 3:1 ratio was the best formulations for use in wound healing.

Pubmed Data : Int J Mol Sci. 2021 Dec 23 ;23(1). Epub 2021 Dec 23. PMID: 35008566
Article Published Date : Dec 22, 2021
Authors : Chuda Chittasupho, Amornrat Manthaisong, Siriporn Okonogi, Sarin Tadtong, Weerasak Samee
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Quercetin : CK(1876) : AC(855)
Diseases : Pseudomonas aeruginosa : CK(483) : AC(365), Wound Healing : CK(4555) : AC(1412)
Pharmacological Actions : Anti-Bacterial Agents : CK(4228) : AC(1989), Antimicrobial : CK(1577) : AC(790), Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

The PI3K/Akt pathway: a target for curcumin's therapeutic effects.

Pubmed Data : J Diabetes Metab Disord. 2025 Jun ;24(1):52. Epub 2025 Jan 17. PMID: 39845908
Article Published Date : May 31, 2025
Authors : Mahdieh Aliyari, Sahar Ghoflchi, Seyed Isaac Hashemy, Seyedeh Fatemeh Hashemi, Amirali Reihani, Hossein Hosseini
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Metabolic Diseases : CK(1273) : AC(272), Neurodegenerative Diseases : CK(13103) : AC(4279)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Neuroprotective Agents : CK(20061) : AC(7949)

The protective effect of curcumin to PTU-induced hepatotoxicity is attributed to its antioxidative properties.

Pubmed Data : Food Chem Toxicol. 2018 Oct 24 ;123:169-180. Epub 2018 Oct 24. PMID: 30367912
Article Published Date : Oct 23, 2018
Authors : Suresh Kumar Bunker, Abinash Dutta, Jyotsnarani Pradhan, Jagneshwar Dandapat, G B N Chainy
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Graves Disease : CK(175) : AC(28), Hyperthyroidism : CK(264) : AC(55)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Epigenetic Modification : CK(586) : AC(216)

The study demonstrated the safety, tolerance, and enhanced efficacy of CGM in comparison with unformulated standard curcumin.

Pubmed Data : J Clin Psychopharmacol. 2016 Jun ;36(3):236-43. PMID: 27043120
Article Published Date : May 31, 2016
Authors : Subash Pandaran Sudheeran, Della Jacob, Johannah Natinga Mulakal, Gopakumar Gopinathan Nair, Abhilash Maliakel, Balu Maliakel, Ramadasan Kuttan, Krishnakumar Im
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Curcuminoids : CK(7851) : AC(3498), Fenugreek : CK(769) : AC(204), Fiber : CK(1656) : AC(217)
Diseases : Anxiety : CK(4246) : AC(759), Stress : CK(1192) : AC(198)
Pharmacological Actions : Anti-Anxiety Agents : CK(4846) : AC(804), Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Blood Brain Barrier : CK(240) : AC(88), Plant Extracts : CK(18762) : AC(6782)

The synergistic hepatoprotective activity of rosemary essential oil and curcumin.

Pubmed Data : Molecules. 2022 Dec 15 ;27(24). Epub 2022 Dec 15. PMID: 36558044
Article Published Date : Dec 14, 2022
Authors : Maged E Mohamed, Nancy S Younis, Hossam S El-Beltagi, Omar M Mohafez
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Rosemary : CK(555) : AC(211)
Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Liver Damage: Drug-Induced : CK(651) : AC(285)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Essential Oils : CK(1005) : AC(429), Natural Substance Synergy : CK(1400) : AC(669)
Problem Substances : Natural Substance Synergy : CK(1400) : AC(669), Paracetamol : CK(863) : AC(298)

Theracurmin has the ability to control lipid metabolism and can potentially serve as an effective therapeutic remedy for the prevention of fatty liver.

Pubmed Data : Toxicol Res. 2019 Oct ;35(4):403-410. Epub 2019 Oct 15. PMID: 31636851
Article Published Date : Sep 30, 2019
Authors : Jin Won Yang, Hee Kyung Yeo, Jee Hye Yun, Jung Un Lee
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Hypolipidemic : CK(9173) : AC(2038)

Therapeutic effect of curcumin and C60 fullerene against hyperglycemia-mediated tissue damage in diabetic rat lungs.

Pubmed Data : J Bioenerg Biomembr. 2021 Feb ;53(1):25-38. Epub 2021 Jan 7. PMID: 33411205
Article Published Date : Jan 31, 2021
Authors : Ersin Demir
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Hyperglycemia : CK(2240) : AC(709), Lung Damage : CK(441) : AC(192)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Antioxidants : CK(34551) : AC(14499)

These findings provide evidence for the beneficial effect of curcumin and carotenoid mixtures as a supplementation having antioxidant and antiatherogenic potentials.

Pubmed Data : Int J Mol Sci. 2017 Mar 23 ;18(4). Epub 2017 Mar 23. PMID: 28333071
Article Published Date : Mar 22, 2017
Authors : Renata Pires Assis, Carlos Alberto Arcaro, Vânia Ortega Gutierres, Juliana Oriel Oliveira, Paulo Inácio Costa, Amanda Martins Baviera, Iguatemy Lourenço Brunetti
Study Type : Animal Study
Additional Links
Substances : Bixin : CK(50) : AC(30), Carotenoids : CK(4462) : AC(1222), Curcumin : CK(7239) : AC(3319), Lycopene : CK(1267) : AC(372), Yoghurt : CK(1142) : AC(159)
Diseases : Diabetes: Oxidative Stress : CK(635) : AC(244), Diabetic Complications : CK(4678) : AC(1606)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963)
Additional Keywords : Risk Reduction : CK(17935) : AC(2006)

This review summarizes the existing evidence regarding the potential role of natural antioxidants in the treatment of NAFLD.

Pubmed Data : Liver Int. 2015 Oct 5. Epub 2015 Oct 5. PMID: 26436447
Article Published Date : Oct 04, 2015
Authors : Federico Salomone, Justyna Godos, Shira Zelber-Sagi
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Resveratrol : CK(3228) : AC(1513)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Trichostatin A works synergistically with curcumin to inhibit human leukemia cells.

Pubmed Data : Pharmazie. 2006 Aug;61(8):710-6. PMID: 16964716
Article Published Date : Aug 01, 2006
Authors : Jie Chen, Hai Bai, Cunbang Wang, Jiuhong Kang
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), NAC (N-acetyl-L-cysteine) : CK(1429) : AC(366), Vitamin C : CK(6066) : AC(1408)
Diseases : Promyelocytic leukemia : CK(163) : AC(138)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Antiproliferative : CK(10001) : AC(7491)
Additional Keywords : Drug Synergy : CK(389) : AC(174)

Turmeric and curcumin inhibit aflatoxin induced hemolysis.

Pubmed Data : Evid Based Complement Alternat Med. 2010 Jan 4. Epub 2010 Jan 4. PMID: 17665866
Article Published Date : Jan 04, 2010
Authors : Neeta Mathuria, Ramtej Jayram Verma
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Aflatoxicosis : CK(301) : AC(109)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Turmeric and curcumin protect against gamma-radiation-induced chromosome aberrations in Chinese hamster ovary cells.

Pubmed Data : Teratog Carcinog Mutagen. 1999;19(1):9-18. PMID: 10321406
Article Published Date : Jan 01, 1999
Authors : M C Araújo, F L Dias, C S Takahashi
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Radiation Induced Illness : CK(1352) : AC(366)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Cell cycle arrest : CK(2120) : AC(1715), Radioprotective : CK(2398) : AC(713)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Turmeric bioactive compounds alleviate spinal nerve ligation-induced neuropathic pain.

Pubmed Data : Nutrients. 2023 Oct 17 ;15(20). Epub 2023 Oct 17. PMID: 37892476
Article Published Date : Oct 16, 2023
Authors : Julianna M Santos, Rui Wang, Viren Bhakta, Zarek Driver, Yakhnitsa Vadim, Takaki Kiritoshi, Guangchen Ji, Volker Neugebauer, Chwan-Li Shen
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Neuropathic Pain : CK(922) : AC(324)
Pharmacological Actions : Analgesics : CK(9680) : AC(1472), Antioxidants : CK(34551) : AC(14499)

Turmeric mitigates xenobiotic exposure.

Pubmed Data : Plant Foods Hum Nutr. 1993 Jul;44(1):87-92. PMID: 8332589
Article Published Date : Jul 01, 1993
Authors : V K Goud, K Polasa, K Krishnaswamy
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Xenobiotic Exposures : CK(20) : AC(8)
Pharmacological Actions : Anticarcinogenic Agents : CK(2152) : AC(1018), Antioxidants : CK(34551) : AC(14499)

Turmeric oil compounds exhibit antioxidant and anti-mutagenic properties.

Pubmed Data : Z Naturforsch C. 2002 Sep-Oct;57(9-10):828-35. PMID: 12440720
Article Published Date : Sep 01, 2002
Authors : Guddadarangavvanahally K Jayaprakasha, Bhabani S Jena, Pradeep S Negi, Kunnumpurath K Sakariah
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904), Turmerones : CK(32) : AC(23)
Diseases : DNA damage : CK(2301) : AC(842)
Pharmacological Actions : Anti-Bacterial Agents : CK(4228) : AC(1989), Antimutagenic Agents : CK(218) : AC(138), Antioxidants : CK(34551) : AC(14499), Genoprotective : CK(522) : AC(203)

Vitamin E and curcumin may alleviate the hepatic antioxidant gene expression in hyperthyroid rats.

Pubmed Data : Chem Biol Interact. 2010 Jan 27;183(2):304-16. Epub 2009 Nov 13. PMID: 19914224
Article Published Date : Jan 27, 2010
Authors : Umakanta Subudhi, Gagan B N Chainy
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Vitamin E : CK(3040) : AC(571)
Diseases : Hyperthyroidism : CK(264) : AC(55)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Vitamin E and curcumin protects hypothyroid-induced altered rectal temperature, serum transaminase activity and hepatic histoarchitecture.

Pubmed Data : Life Sci. 2009 Mar 13;84(11-12):372-9. Epub 2009 Jan 13. PMID: 19174171
Article Published Date : Mar 13, 2009
Authors : Umakanta Subudhi, Kajari Das, Biswaranjan Paital, Shravani Bhanja, Gagan B N Chainy
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Vitamin E : CK(3040) : AC(571)
Diseases : Hypothyroidism : CK(863) : AC(152)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Wound-healing effects of curcumin and its nanoformulations.

Pubmed Data : Pharmaceutics. 2022 Oct 25 ;14(11). Epub 2022 Oct 25. PMID: 36365107
Article Published Date : Oct 24, 2022
Authors : Amrita Kumari, Neha Raina, Abhishek Wahi, Khang Wen Goh, Pratibha Sharma, Riya Nagpal, Atul Jain, Long Chiau Ming, Madhu Gupta
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Wound Healing : CK(4555) : AC(1412)
Pharmacological Actions : Anti-Bacterial Agents : CK(4228) : AC(1989), Antioxidants : CK(34551) : AC(14499)
Additional Keywords : Antioxidants : CK(34551) : AC(14499)

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