Focused Research Topics Curcumin & Hepatoprotective

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Associated Topics included in this Focused Research

Curcumin Curcumin: Lipidated

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162 Research Articles in Total

A review of turmeric and its major compound curcumin on health.

Pubmed Data : Front Pharmacol. 2020 ;11:01021. Epub 2020 Sep 15. PMID: 33041781
Article Published Date : Dec 31, 2019
Authors : Javad Sharifi-Rad, Youssef El Rayess, Alain Abi Rizk, Carmen Sadaka, Raviella Zgheib, Wissam Zam, Simona Sestito, Simona Rapposelli, Katarzyna Neffe-Skocińska, Dorota Zielińska, Bahare Salehi, William N Setzer, Noura S Dosoky, Yasaman Taheri, Marc El Beyrouthy, Miquel Martorell, Elise Adrian Ostrander, Hafiz Ansar Rasul Suleria, William C Cho, Alfred Maroyi, Natália Martins
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963), Hepatoprotective : CK(8989) : AC(3831), Neuroprotective Agents : CK(20061) : AC(7949)

Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies.

Pubmed Data : Nutrients. 2020 Jan 1 ;12(1). Epub 2020 Jan 1. PMID: 31906278
Article Published Date : Dec 31, 2019
Authors : Danja J Den Hartogh, Alessandra Gabriel, Evangelia Tsiani
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetes Mellitus: Type 2 : CK(12953) : AC(2579)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Hypoglycemic Agents : CK(9221) : AC(2076), Immunomodulatory : CK(6531) : AC(2360), Renoprotective : CK(4544) : AC(1971)

Curcumin alleviates hepatic ischemia-reperfusion injury.

Pubmed Data : J Invest Surg. 2023 Dec ;36(1):2164813. PMID: 36603844
Article Published Date : Nov 30, 2023
Authors : Cunle Zhu, Shangheng Shi, Peng Jiang, Xijian Huang, Jinxin Zhao, Yan Jin, Yuntai Shen, Xin Zhou, Huan Liu, Jinzhen Cai
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Inflammation : CK(16108) : AC(5498), Liver Damage : CK(4109) : AC(1872), Liver Injury: Ischemia/reperfusion : CK(175) : AC(95)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831)

Curcumin ameliorates lead-induced hepatotoxicity.

Pubmed Data : Biomolecules. 2019 Nov 5 ;9(11). Epub 2019 Nov 5. PMID: 31694300
Article Published Date : Nov 04, 2019
Authors : Ahlam Alhusaini, Laila Fadda, Iman H Hasan, Enas Zakaria, Abeer M Alenazi, Ayman M Mahmoud
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Inflammation : CK(16108) : AC(5498)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)
Problem Substances : Lead : CK(700) : AC(231)

Curcumin and capsaicin treatments attenuated hepatic fat accumulation and increased leptin levels related to inflammation.

Pubmed Data : Arch Physiol Biochem. 2015 Dec 26:1-29. Epub 2015 Dec 26. PMID: 26706937
Article Published Date : Dec 25, 2015
Authors : Muhammed Seyithanoğlu, Yıldız Öner-İyidoğan, Semra Doğru-Abbasoğlu, Sevda Tanrıkulu-Küçük, Hikmet Koçak, Şule Beyhan-Özdaş, Necla Koçak-Toker
Study Type : Animal Study
Additional Links
Substances : Capsaicin : CK(338) : AC(129), Curcumin : CK(7239) : AC(3319)
Diseases : High Fat Diet : CK(2040) : AC(984)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831)

Curcumin attenuates Concanavalin A-induced liver injury in mice.

Pubmed Data : Int Immunopharmacol. 2012 Jan ;12(1):151-7. Epub 2011 Dec 2. PMID: 22138522
Article Published Date : Dec 31, 2011
Authors : Chuan-tao Tu, Bing Han, Qun-yan Yao, Yi-an Zhang, Hong-chun Liu, Shun-cai Zhang
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Hepatitis: Lectin-Induced (concanavalin) : CK(58) : AC(31)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831)

Curcumin inhibits HMGB1 releasing and attenuates concanavalin A-induced hepatitis in mice.

Pubmed Data : Eur J Pharmacol. 2012 Oct 11. Epub 2012 Oct 11. PMID: 23063543
Article Published Date : Oct 10, 2012
Authors : Chao Wang, Hao Nie, Kan Li, Yan-Xiang Zhang, Fei Yang, Cheng-Bin Li, Chang-Fu Wang, Quan Gong
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Hepatitis: Lectin-Induced (concanavalin) : CK(58) : AC(31)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831), High-mobility group box-1 (HMGB1) inhibitor : CK(2) : AC(1)

Curcumin may be considered as protective factor against inflammatory state of PCOS.

Pubmed Data : Cell J. 2017 Oct ;19(3):425-433. Epub 2017 Aug 19. PMID: 28836404
Article Published Date : Sep 30, 2017
Authors : Shima Mohammadi, Latifeh Karimzadeh Bardei, Vida Hojati, Azita Ghorbani Ghorbani, Mohammad Nabiuni
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Polycystic Ovary Syndrome : CK(2116) : AC(332)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831), Insulin Sensitizers : CK(1957) : AC(422), Interleukin-6 Downregulation : CK(9337) : AC(3613)

Curcumin protected the liver from chronic-ethanol induced injury through attenuating oxidative stress

Pubmed Data : Pharmacogn Mag. 2015 Oct-Dec;11(44):707-715. PMID: 26600714
Article Published Date : Sep 30, 2015
Authors : Zhang E Xiong, Wei Guo Dong, Bao Ying Wang, Qiao Yun Tong, Zhong Yan Li
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alcoholic Liver Disease : CK(611) : AC(283)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Nrf2 activation : CK(3156) : AC(1794)

Curcumin protects mice from P. acnes-induced liver injury through reduction of HMGB1 cytoplasmic translocation and expression.

Pubmed Data : Int Immunopharmacol. 2015 Feb ;24(2):159-65. Epub 2014 Dec 13. PMID: 25510585
Article Published Date : Jan 31, 2015
Authors : Qiaoli Gu, Honggeng Guan, Qin Shi, Yanyun Zhang, Huilin Yang
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Acne : CK(943) : AC(168), Gram-Negative Bacterial Infections : CK(135) : AC(99)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831)

Curcumin supplementation mitigates NASH development and progression in female Wistar rats.

Pubmed Data : Physiol Rep. 2018 Jul ;6(14):e13789. PMID: 30009570
Article Published Date : Jun 30, 2018
Authors : Rory P Cunningham, Mary P Moore, Angelique N Moore, James C Healy, Michael D Roberts, R Scott Rector, Jeffrey S Martin
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin treatment attenuates lipopolysaccharide induced liver injury.

Pubmed Data : Biomed Pharmacother. 2016 Jul 6 ;83:302-313. Epub 2016 Jul 6. PMID: 27393927
Article Published Date : Jul 05, 2016
Authors : Wenhui Zhong, Kejian Qian, Jibin Xiong, Ke Ma, Aizhong Wang, Yan Zou
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875), Sepsis : CK(1436) : AC(491)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin treatment attenuates liver lesions induced by intestinal ischemia/reperfusion.

Pubmed Data : Oxid Med Cell Longev. 2014 ;2014:191624. Epub 2014 Aug 20. PMID: 25215173
Article Published Date : Dec 31, 2013
Authors : Zhe Fan, Huirong Jing, Jihong Yao, Yang Li, Xiaowei Hu, Huizhu Shao, Gang Shen, Jiyong Pan, Fuwen Luo, Xiaofeng Tian
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Intestinal Ischemia : CK(64) : AC(32), Liver Damage : CK(4109) : AC(1872)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831), Interleukin-6 Downregulation : CK(9337) : AC(3613), NF-kappaB Inhibitor : CK(5952) : AC(3464), Superoxide Dismutase Up-regulation : CK(2383) : AC(928)

Curcumin-galactomannoside complex offered significant hepatoprotective effects to attenuate alcohol induced alterations to hepatic function markers.

Pubmed Data : Biomed Res Int. 2018 ;2018:9159281. Epub 2018 Sep 23. PMID: 30345312
Article Published Date : Dec 31, 2017
Authors : Naveen T Krishnareddy, Jestin V Thomas, Saritha S Nair, Johannah N Mulakal, Balu P Maliakel, I M Krishnakumar
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alcohol Toxicity : CK(1235) : AC(480), Alcoholic Liver Disease : CK(611) : AC(283)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Dual anti-inflammatory effects of curcumin and berberine on acetaminophen-induced liver injury.

Pubmed Data : Biochem Biophys Res Commun. 2024 Nov 19 ;734:150772. Epub 2024 Sep 30. PMID: 39362031
Article Published Date : Nov 18, 2024
Authors : Fengguo Zhai, Jiale Wang, Xueying Wan, Yue Liu, Xu Mao
Study Type : Animal Study
Additional Links
Substances : Berberine : CK(2483) : AC(1079), Curcumin : CK(7239) : AC(3319)
Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Liver Damage: Drug-Induced : CK(651) : AC(285)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831), NF-kappaB Inhibitor : CK(5952) : AC(3464)
Problem Substances : NF-kappaB Inhibitor : CK(5952) : AC(3464), Paracetamol : CK(863) : AC(298)

Hepatoprotective effects of albumin-encapsulated nanoparticles of a curcumin derivative COP-22 against lipopolysaccharide/D-galactosamine-induced acute liver injury.

Pubmed Data : Int J Mol Sci. 2022 Apr 28 ;23(9). Epub 2022 Apr 28. PMID: 35563293
Article Published Date : Apr 27, 2022
Authors : Wenwen Mu, Qi Wang, Mingxia Jia, Sijia Dong, Sijie Li, Jie Yang, Guoyun Liu
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875), Liver Damage : CK(4109) : AC(1872)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Liposomal curcumin may be useful for the prevention of copper sulphate induced liver injury.

Pubmed Data : Dose Response. 2018 Jul-Sep;16(3):1559325818790869. Epub 2018 Aug 9. PMID: 30116168
Article Published Date : Jun 30, 2018
Authors : Ahlam Alhusaini, Laila Fadda, Iman Hassan, Hanaa M Ali, Njood Alsaadan, Nouf Aldowsari, Azizah Aldosari, Bshayer Alharbi
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Copper Toxicity : CK(49) : AC(23)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Natural Substances Versus Drugs : CK(2806) : AC(560)

Mechanistic insights of hepatoprotective effects of curcumin.

Pubmed Data : Food Chem Toxicol. 2019 Feb ;124:182-191. Epub 2018 Dec 5. PMID: 30529260
Article Published Date : Jan 31, 2019
Authors : Haroon Khan, Hammad Ullah, Seyed M Nabavi
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Chemically-Induced Liver Damage : CK(2304) : AC(1089), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

The combination of curcumin and berberine exhibited better ameliorative effects in treating NAFLD than lovastatin.

Pubmed Data : Biomed Pharmacother. 2018 Jan 17 ;99:325-333. Epub 2018 Jan 17. PMID: 29353208
Article Published Date : Jan 16, 2018
Authors : Wu-Wen Feng, Shuang-Yu Kuang, Can Tu, Zhi-Jie Ma, Jing-Yao Pang, Yan-Hui Wang, Qing-Ce Zang, Ta-Si Liu, Yan-Ling Zhao, Xiao-He Xiao, Jia-Bo Wang
Study Type : Animal Study
Additional Links
Substances : Berberine : CK(2483) : AC(1079), Curcumin : CK(7239) : AC(3319)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Superiority of Natural Substances versus Drugs : CK(1875) : AC(394)

Curcumin attenuates oxidative stress and inflammatory response in the early phase after partial hepatectomy with simultaneous intraabdominal infection in rats.

Pubmed Data : J Surg Res. 2010 Mar;159(1):497-502. Epub 2008 Dec 31. PMID: 19321178
Article Published Date : Mar 01, 2010
Authors : Daniel Seehofer, Anja Schirmeier, Stig Bengmark, Si-Young Ria Cho, Martin Koch, Andri Lederer, Nada Rayes, Michael D Menger, Peter Neuhaus, Andreas K Nüssler
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Inflammation : CK(16108) : AC(5498), Liver Disease : CK(367) : AC(117), Liver Surgery : CK(16) : AC(4), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Curcumin protects against Aflatoxin B1-induced liver injury.

Pubmed Data : Ecotoxicol Environ Saf. 2021 Jan 15 ;208:111725. Epub 2020 Dec 5. PMID: 33396056
Article Published Date : Jan 14, 2021
Authors : Sihong Li, Ruimeng Liu, Gaoqiang Wei, Guifang Guo, Hongxiao Yu, Yixin Zhang, Muhammad Ishfaq, Saqib Ali Fazilani, Xiuying Zhang
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Inflammation : CK(16108) : AC(5498), Liver Damage: Aflatoxin-Induced : CK(104) : AC(48), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin (in low doses) is protective against ethanol-induced liver damage.

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):47-60. Epub 2008 Aug 21. PMID: 18716759
Article Published Date : Jan 01, 2009
Authors : Asser I Ghoneim
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alcohol Toxicity : CK(1235) : AC(480), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Apoptotic : CK(9585) : AC(7379), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Less is More : CK(21) : AC(3)

Curcumin ameliorates acute thioacetamide-induced hepatotoxicity.

Pubmed Data : J Gastroenterol Hepatol. 2006 Feb;21(2):358-66. PMID: 16509859
Article Published Date : Feb 01, 2006
Authors : Haim Shapiro, Michal Ashkenazi, Nir Weizman, Mark Shahmurov, Hussein Aeed, Rafael Bruck
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Enzyme Inhibitors : CK(846) : AC(399), Hepatoprotective : CK(8989) : AC(3831), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin ameliorates aflatoxin-induced lipid-peroxidation in liver and kidney of mice.

Pubmed Data : Acta Pol Pharm. 2008 Mar-Apr;65(2):195-202. PMID: 18666425
Article Published Date : Mar 01, 2008
Authors : Ramtej J Verma, Neeta Mathuria
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aflatoxicosis : CK(301) : AC(109), Cholesterol: Oxidation : CK(654) : AC(159), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831), Renoprotective : CK(4544) : AC(1971)

Curcumin attenuates alcohol toxicity.

Pubmed Data : J Pharm Pharm Sci. 2004 Aug 20;7(2):274-83. Epub 2004 Aug 20. PMID: 15367386
Article Published Date : Aug 20, 2004
Authors : Rajagopalan Rukkumani, Kode Aruna, Penumathsa Suresh Varma, Kallikat Narayanan Rajasekaran, Venugopal Padmanabhan Menon
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alcohol Toxicity : CK(1235) : AC(480), Chemically-Induced Liver Damage : CK(2304) : AC(1089), Lipid Peroxidation : CK(2057) : AC(806), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin attenuates cadmium-induced tisse damage in mice.

Pubmed Data : J Appl Toxicol. 2006 May-Jun;26(3):207-12. PMID: 16345010
Article Published Date : May 01, 2006
Authors : Vladislav Eybl, Dana Kotyzová, Ladislav Lesetický, Monika Bludovská, Jaroslav Koutenský
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cadmium Poisoning : CK(439) : AC(225), Lipid Peroxidation : CK(2057) : AC(806), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin attenuates dimethylnitrosamine-induced liver injury in rats.

Pubmed Data : Food Chem Toxicol. 2008 Apr;46(4):1279-87. Epub 2007 Sep 26. PMID: 18006204
Article Published Date : Apr 01, 2008
Authors : E Olatunde Farombi, Sangeeta Shrotriya, Hye-Kyung Na, Sung-Hoon Kim, Young-Joon Surh
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Anticarcinogenic Agents : CK(2152) : AC(1018), Hepatoprotective : CK(8989) : AC(3831)

Curcumin enhanced therapeutic efficacy of M. oleifera root extract and showed better antioxidant potential against beryllium toxicity.

Pubmed Data : Pharm Biol. 2015 Oct ;53(10):1465-73. Epub 2015 Apr 8. PMID: 25853973
Article Published Date : Sep 30, 2015
Authors : Narottam Das Agrawal, Satendra Kumar Nirala, Sangeeta Shukla, Ramesh Mathur
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Moringa oleifera : CK(748) : AC(377)
Diseases : Beryllium-induced Toxicity : CK(4) : AC(2), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Renoprotective : CK(4544) : AC(1971)

Curcumin inhibits lipid peroxidation and protein oxidation in rat liver mitochondria.

Pubmed Data : Biochim Biophys Acta. 2006 Jan;1760(1):70-7. Epub 2005 Oct 3. PMID: 16236451
Article Published Date : Jan 01, 2006
Authors : Qing-Yi Wei, Wei-Feng Chen, Bo Zhou, Li Yang, Zhong-Li Liu
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Lipid Peroxidation : CK(2057) : AC(806), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin limits the fibrogenic evolution of experimental fatty liver.

Pubmed Data : Lab Invest. 2010 Jan;90(1):104-15. Epub 2009 Nov 9. PMID: 19901911
Article Published Date : Jan 01, 2010
Authors : Francesco Vizzutti, Angela Provenzano, Sara Galastri, Stefano Milani, Wanda Delogu, Erica Novo, Alessandra Caligiuri, Elena Zamara, Umberto Arena, Giacomo Laffi, Maurizio Parola, Massimo Pinzani, Fabio Marra
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Fatty Liver : CK(4309) : AC(1216), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Enzyme Inhibitors : CK(846) : AC(399), Hepatoprotective : CK(8989) : AC(3831)

Curcumin may be effective in the management of diet-induced oxidative stress.

Pubmed Data : Sci Pharm. 2015 ;83(1):159-75. Epub 2014 Nov 4. PMID: 26839808
Article Published Date : Dec 31, 2014
Authors : Nachimuthu Maithili Karpaga Selvi, Magadi Gopalakrishna Sridhar, Rathinam Palamalai Swaminathan, Ramalingam Sripradha
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : High Fat Diet : CK(2040) : AC(984), High Fructose Diet : CK(474) : AC(187), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Malondialdehyde Down-regulation : CK(3028) : AC(992), Renoprotective : CK(4544) : AC(1971)

Curcumin pretreatment protects against acute acrylonitrile-induced oxidative damage in rats.

Pubmed Data : Radiat Oncol. 2010 Nov 22;5(1):111. Epub 2010 Nov 22. PMID: 19913070
Article Published Date : Nov 22, 2010
Authors : Xing Guangwei, Lu Rongzhu, Xu Wenrong, Wang Suhua, Zhao Xiaowu, Wang Shizhong, Zhang Ye, Michael Aschner, Shrinivas K Kulkarni, Mahendra Bishnoi
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemical Exposure: Acrylonitrile : CK(4) : AC(2), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Neuroprotective Agents : CK(20061) : AC(7949)

Curcumin protects against acute liver damage in the rat.

Pubmed Data : Biochim Biophys Acta. 2007 Jun;1770(6):989-96. Epub 2007 Feb 22. PMID: 17383825
Article Published Date : Jun 01, 2007
Authors : Karina Reyes-Gordillo, José Segovia, Mineko Shibayama, Paula Vergara, Mario G Moreno, Pablo Muriel
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin protects rats against acetaminophen-induced hepatorenal damages and shows synergistic activity with N-acetyl cysteine.

Pubmed Data : Eur J Pharmacol. 2010 Feb 25;628(1-3):274-81. Epub 2009 Nov 15. PMID: 19919835
Article Published Date : Feb 25, 2010
Authors : Ehsan Kheradpezhouh, Mohammad-Reza Panjehshahin, Ramin Miri, Katayoun Javidnia, Ali Noorafshan, Ahmad Monabati, Ahmad-Reza Dehpour
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), NAC (N-acetyl-L-cysteine) : CK(1429) : AC(366)
Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831), Renoprotective : CK(4544) : AC(1971)
Additional Keywords : Drug Synergy : CK(389) : AC(174)

curcumin reduces markers of liver damage in rats treated with heated sunflower oil or ethanol.

Pubmed Data : Vet Ital. 2010 Jan-Mar;46(1):83-92. PMID: 20391370
Article Published Date : Jan 01, 2010
Authors : Nasr A M N El-Deen, Mohamed Eid
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alcohol Toxicity : CK(1235) : AC(480), Liver Damage: Drug-Induced : CK(651) : AC(285), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin reduces rat hepatic fibrosis.

Pubmed Data : Zhonghua Gan Zang Bing Za Zhi. 2007 Oct;15(10):753-7. PMID: 17963602
Article Published Date : Oct 01, 2007
Authors : Jian-chang Shu, Guo-rong Ye, Xia Lü, Li Fang, Hai-en Wu, Xiao-juan Chen
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Fibrosis : CK(882) : AC(399), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Curcumin reduces the toxic effects of iron loading in rat liver epithelial cells.

Pubmed Data : Liver Int. 2009 Jan;29(1):63-72. Epub 2008 May 19. PMID: 18492020
Article Published Date : Jan 01, 2009
Authors : Donald J Messner, Gowsala Sivam, Kris V Kowdley
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Iron Overload : CK(220) : AC(79), Iron Poisoning : CK(22) : AC(10), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Curcumin suppresses chemically-induced oxidative stress in the mouse liver.

Pubmed Data : Prog Biophys Mol Biol. 2007 Jan-Apr;93(1-3):295-300. Epub 2006 Aug 22. PMID: 11234915
Article Published Date : Jan 01, 2007
Authors : S Watanabe, T Fukui
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Enzyme Inhibitors : CK(846) : AC(399), Hepatoprotective : CK(8989) : AC(3831)

Curcumin, capsaicin and garlic inhibit adverse blood and liver changes associated wtih a high-fat diet in rats.

Pubmed Data : Ann Nutr Metab. 2004 Sep-Oct;48(5):314-20. Epub 2004 Oct 1. PMID: 15467281
Article Published Date : Sep 01, 2004
Authors : R K Kempaiah, K Srinivasan
Study Type : Animal Study
Additional Links
Substances : Capsaicin : CK(338) : AC(129), Curcumin : CK(7239) : AC(3319), Garlic : CK(2194) : AC(727)
Diseases : Hyperlipidemia : CK(2140) : AC(553), Liver Disease : CK(367) : AC(117), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Diallyl sulfide and curcumin effectively reduced Thallium acetate induced liver toxicity.

Pubmed Data : Cell J. 2015 ;17(2):379-88. Epub 2015 Jul 11. PMID: 26199917
Article Published Date : Dec 31, 2014
Authors : Mohamed M Abdel-Daim, Rania H Abdou
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Diallyl sulfide : CK(61) : AC(37)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Oxidative Stress : CK(14758) : AC(5716), Thallium Poisoning : CK(2) : AC(1)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Dietary curcumin supplementation attenuates hepatic damage and function abnormality in a chronic corticosterone-induced stress model in broilers.

Pubmed Data : J Steroid Biochem Mol Biol. 2024 Oct ;243:106579. Epub 2024 Jul 19. PMID: 39032671
Article Published Date : Sep 30, 2024
Authors : Xuemei Shan, Xingyu Xu, Lijun Wang, Yao Lu, Xinyu Chen, Fei Li, Min Du, Hua Xing, Shifeng Pan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Embelin and curcumin have a beneficial effect against oxidative tissue damage during chemically-induced hepatocarinogenesis in rats.

Pubmed Data : Mol Cell Biochem. 2006 Mar;284(1-2):49-55. Epub 2006 Feb 14. PMID: 16477385
Article Published Date : Mar 01, 2006
Authors : Meenakshisundaram Sreepriya, Geetha Bali
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Embelia ribes : CK(16) : AC(8)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Drug Synergy : CK(389) : AC(174)

Protective effects of curcumin and silymarin against paracetamol induced hepatotoxicity.

Pubmed Data : Gene. 2019 Sep 5 ;712:143966. Epub 2019 Jul 4. PMID: 31279711
Article Published Date : Sep 04, 2019
Authors : Marwa M Ahmad, Noha A Rezk, Amal Fawzy, Mohamed Sabry
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Silymarin : CK(455) : AC(112)
Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669), Plant Extracts : CK(18762) : AC(6782)
Problem Substances : Plant Extracts : CK(18762) : AC(6782), Paracetamol : CK(863) : AC(298)

Synergistic effect of black tea and curcumin in improving the hepatotoxicity induced by aflatoxin B1.

Pubmed Data : Toxicol Ind Health. 2015 Dec ;31(12):1269-80. Epub 2013 Jun 24. PMID: 23796760
Article Published Date : Nov 30, 2015
Authors : Abeer A Alm-Eldeen, Mohamed H Mona, Ali A Shati, Haitham I El-Mekkawy
Study Type : Animal Study
Additional Links
Substances : Black Tea : CK(1050) : AC(265), Curcumin : CK(7239) : AC(3319)
Diseases : Lipid Peroxidation : CK(2057) : AC(806), Liver Damage: Aflatoxin-Induced : CK(104) : AC(48), Oxidative Stress : CK(14758) : AC(5716)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)
Problem Substances : Aflatoxin : CK(230) : AC(87)

Curcumin exhibits inhibitory effects liver fibrosis associated with injury.

Pubmed Data : Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G20-30. Epub 2003 Mar 26. PMID: 12660143
Article Published Date : Jul 01, 2003
Authors : Jianye Xu, Yumei Fu, Anping Chen
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Fibrosis : CK(882) : AC(399)
Pharmacological Actions : Antineoplastic Agents : CK(2235) : AC(1468), Antioxidants : CK(34551) : AC(14499), Antiproliferative : CK(10001) : AC(7491), Hepatoprotective : CK(8989) : AC(3831), NF-kappaB Inhibitor : CK(5952) : AC(3464)
Additional Keywords : Drug Synergy : CK(389) : AC(174)

Curcumin inhibits chemically-induced liver cancer.

Pubmed Data : Food Chem Toxicol. 2000 Nov;38(11):991-5. PMID: 11038236
Article Published Date : Nov 01, 2000
Authors : S E Chuang, A L Cheng, J K Lin, M L Kuo
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Chemopreventive : CK(6580) : AC(2166), Hepatoprotective : CK(8989) : AC(3831), NF-kappaB Inhibitor : CK(5952) : AC(3464), Tumor Suppressor Protein p53 Upregulation : CK(755) : AC(554)

Curcumin inhibits NF-kappaB activation and reduces the severity of experimental fatty liver in mice.

Pubmed Data : Mech Ageing Dev. 2003 Dec;124(10-12):1025-34. PMID: 15582125
Article Published Date : Dec 01, 2003
Authors : Isabelle A Leclercq, Geoffrey C Farrell, Christine Sempoux, Aileen dela Peña, Yves Horsmans
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Fatty Liver : CK(4309) : AC(1216)
Pharmacological Actions : Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327), Enzyme Inhibitors : CK(846) : AC(399), Hepatoprotective : CK(8989) : AC(3831), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin prevents alcohol-induced liver disease in rats.

Pubmed Data : Am J Physiol Gastrointest Liver Physiol. 2003 Feb;284(2):G321-7. Epub 2002 Aug 28. PMID: 12388178
Article Published Date : Feb 01, 2003
Authors : Amin A Nanji, Kalle Jokelainen, George L Tipoe, Amir Rahemtulla, Peter Thomas, Andrew J Dannenberg
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alcoholic Liver Disease : CK(611) : AC(283)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831), NF-kappaB Inhibitor : CK(5952) : AC(3464)

Curcumin inhibits liver injury in a mouse model of endotoxemic shock.

Pubmed Data : Biotechnol Lett. 2010 Feb;32(2):209-14. Epub 2009 Oct 25. PMID: 19856147
Article Published Date : Feb 01, 2010
Authors : Sang Sik Yun, Sung Phil Kim, Mi Young Kang, Seok Hyun Nam
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Endotoxemia : CK(359) : AC(127), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Curcumin protects against experimental liver injury in mice.

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2003 Aug;28(8):756-8, 793. PMID: 15015361
Article Published Date : Aug 01, 2003
Authors : Yong-gang Liu, Hou-chang Chen, Yi-ping Jiang
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Lipopolysaccharide-Induced Toxicity : CK(3229) : AC(1875)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Curcumin and NAC protect against valproate-induced liver toxicity.

Pubmed Data : Arzneimittelforschung. 2010;60(11):647-53. PMID: 21175036
Article Published Date : Jan 01, 2010
Authors : Shehta Abd-Allah Said, Dina Saad El-Agamy
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), NAC (N-acetyl-L-cysteine) : CK(1429) : AC(366)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Drug-Induced Toxicity: Valproic Acid (Depakote) : CK(8) : AC(4)
Pharmacological Actions : Anticonvulsants : CK(1163) : AC(299), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Combination of vitamin C and curcumin safeguards against methotrexate-induced acute liver injury.

Pubmed Data : Front Med (Lausanne). 2022 ;9:866343. Epub 2022 Apr 14. PMID: 35492324
Article Published Date : Dec 31, 2021
Authors : Dhekra Hasan Khudhair, Ali I Al-Gareeb, Hayder M Al-Kuraishy, Aya H El-Kadem, Engy Elekhnawy, Walaa A Negm, Sameh Saber, Simona Cavalu, Adrian Tirla, Saqer S Alotaibi, Gaber El-Saber Batiha
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Vitamin C : CK(6066) : AC(1408)
Diseases : Drug Toxicity: Methotrexate : CK(194) : AC(100), Liver Damage: Drug-Induced : CK(651) : AC(285)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

Curcumin ameliorates aflatoxin-induced toxicity in DNA, RNA and protein in liver and kidney of mice.

Pubmed Data : Acta Pol Pharm. 2007 Nov-Dec;64(6):497-502. PMID: 18323242
Article Published Date : Nov 01, 2007
Authors : Neeta Mathuria, Ramtej Jayram Verma
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aflatoxicosis : CK(301) : AC(109)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Renoprotective : CK(4544) : AC(1971)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Curcumin and a curcumin copper complex has a radioprotective effect in mouse livers.

Pubmed Data : J Radiat Res (Tokyo). 2007 May;48(3):241-5. Epub 2007 Apr 27. PMID: 17464095
Article Published Date : May 01, 2007
Authors : Prabhakar R Koiram, Veeresh P Veerapur, Amit Kunwar, Beena Mishra, Atanu Barik, Indira K Priyadarsini, Unnikrishnan K Mazhuvancherry
Study Type : Animal Study
Additional Links
Substances : Copper : CK(146) : AC(30), Curcumin : CK(7239) : AC(3319)
Diseases : Radiation Induced Illness : CK(1352) : AC(366), Radiation Induced Illness: Liver : CK(2) : AC(1)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Radioprotective : CK(2398) : AC(713)

Curcumin and eugenol prevents lipid peroxidation of rat liver microsomes.

Pubmed Data : Mol Cell Biochem. 1992 Apr;111(1-2):117-24. PMID: 1588934
Article Published Date : Apr 01, 1992
Authors : A C Reddy, B R Lokesh
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Eugenol : CK(219) : AC(133)
Diseases : Lipid Peroxidation : CK(2057) : AC(806)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin and turmeric extract might be recommendable to recover liver activity.

Pubmed Data : Sci Rep. 2017 Jul 26 ;7(1):6513. Epub 2017 Jul 26. PMID: 28747775
Article Published Date : Jul 25, 2017
Authors : Hwa-Young Lee, Seung-Wook Kim, Geum-Hwa Lee, Min-Kyung Choi, Han-Wool Chung, Yong-Chul Lee, Hyung-Ryong Kim, Ho Jeong Kwon, Han-Jung Chae
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin as a therapeutic strategy in liver diseases.

Pubmed Data : Nutrients. 2019 Oct 17 ;11(10). Epub 2019 Oct 17. PMID: 31627369
Article Published Date : Oct 16, 2019
Authors : Rita Rezzani, Caterina Franco, Luigi Fabrizio Rodella
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Disease : CK(367) : AC(117), Liver Failure: Acute : CK(57) : AC(25), Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin could be useful to protect the liver from nicotine toxicity.

Pubmed Data : J Tradit Complement Med. 2016 Apr ;6(2):176-83. Epub 2015 Jan 31. PMID: 27114942
Article Published Date : Mar 31, 2016
Authors : Mohammadreza Salahshoor, Sabah Mohamadian, Seyran Kakabaraei, Shiva Roshankhah, Cyrus Jalili
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Nicotine/Tobacco Toxicity : CK(273) : AC(108)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin exhibits hepatoprotective properties against selenium toxicity.

Pubmed Data : Indian J Physiol Pharmacol. 2005 Jan;49(1):111-4. PMID: 15881869
Article Published Date : Jan 01, 2005
Authors : S Padmaja, T N Raju
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Selenium : CK(1753) : AC(393)
Diseases : Selenium Toxicity (Selenosis) : CK(2) : AC(1)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Enzyme Inhibitors : CK(846) : AC(399), Hepatoprotective : CK(8989) : AC(3831)

Curcumin prevents acrylamide-induced DNA damage in liver cells.

Pubmed Data : Wei Sheng Yan Jiu. 2009 Jul;38(4):392-5. PMID: 19689063
Article Published Date : Jul 01, 2009
Authors : Jun Cao, Liping Jiang, Chengyan Geng, Xiaofeng Yao
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Acrylamide-induced toxicity : CK(121) : AC(69), DNA damage : CK(2301) : AC(842)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin prevents proteins expression changes of oxidative phosphorylation, cellular stress response, and lipid metabolism proteins in liver of mice fed a high-fructose diet.

Pubmed Data : J Proteomics. 2022 Apr 29 ;263:104595. Epub 2022 Apr 29. PMID: 35490921
Article Published Date : Apr 28, 2022
Authors : Oscar Gerardo Silva-Gaona, Magdalena Hernández-Ortiz, Katya Vargas-Ortiz, Joel Ramírez-Emiliano, Ma Eugenia Garay-Sevilla, Sergio Encarnación-Guevara, Victoriano Pérez-Vázquez
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : High Fructose Diet : CK(474) : AC(187), Liver Damage : CK(4109) : AC(1872)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Hypolipidemic : CK(9173) : AC(2038)

Curcumin protects against chemically-induced liver damage in rats.

Pubmed Data : Life Sci. 2006 Apr 4;78(19):2188-93. Epub 2005 Nov 8. PMID: 16288784
Article Published Date : Apr 04, 2006
Authors : Tomomi Sugiyama, Jun-ichi Nagata, Azumi Yamagishi, Kaori Endoh, Morio Saito, Kazuhiko Yamada, Shizuo Yamada, Keizo Umegaki
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin protects against oxidative and nitrative stress after praziquantel treatment in liver fluke-infected hamsters.

Pubmed Data : Int J Parasitol. 2011 Jan 21. Epub 2011 Jan 21. PMID: 21256849
Article Published Date : Jan 21, 2011
Authors : Lakhanawan Charoensuk, Porntip Pinlaor, Suksanti Prakobwong, Yusuke Hiraku, Umawadee Laothong, Wipaporn Ruangjirachuporn, Puangrat Yongvanit, Somchai Pinlaor
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Drug-Induced Toxicity : CK(562) : AC(83), Parasitic Diseases : CK(140) : AC(72)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcumin, capsaicin, and garlic have a beneficial effect in the red blood cells and liver of cholesterol fed rats.

Pubmed Data : Acta Pharmacol Sin. 2007 Oct;28(10):1559-65. PMID: 15296079
Article Published Date : Oct 01, 2007
Authors : R K Kempaiah, K Srinivasan
Study Type : Animal Study
Additional Links
Substances : Capsaicin : CK(338) : AC(129), Curcumin : CK(7239) : AC(3319), Garlic : CK(2194) : AC(727)
Diseases : High Cholesterol : CK(3091) : AC(530)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Cardioprotective : CK(9504) : AC(2963), Hepatoprotective : CK(8989) : AC(3831)

Evaluation of the hepatoprotective effects of curcumin and nanocurcumin against paraquat-induced liver injury.

Pubmed Data : J Biochem Mol Toxicol. 2021 Feb 5:e22739. Epub 2021 Feb 5. PMID: 33544450
Article Published Date : Feb 04, 2021
Authors : Nejat Kheiripour, Alireza Plarak, Ali Heshmati, Sara Soleimani Asl, Fereshteh Mehri, Alireza Ebadollahi-Natanzi, Akram Ranjbar, Asieh Hosseini
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Pesticide Toxicity : CK(1467) : AC(478)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Heme oxygenase-1 up-regulation : CK(1336) : AC(776), Hepatoprotective : CK(8989) : AC(3831), Nrf2 activation : CK(3156) : AC(1794)
Problem Substances : Paraquat : CK(190) : AC(94)

Liposomal curcumin is better than curcumin to alleviate complications in experimental diabetic mellitus.

Pubmed Data : Molecules. 2019 Feb 27 ;24(5). Epub 2019 Feb 27. PMID: 30818888
Article Published Date : Feb 26, 2019
Authors : Adriana Elena Bulboacă, Alina S Porfire, Lucia R Tefas, Paul Mihai Boarescu, Sorana D Bolboacă, Ioana C Stănescu, Angelo Corneliu Bulboacă, Gabriela Dogaru
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetes: Oxidative Stress : CK(635) : AC(244), Diabetic Complications : CK(4678) : AC(1606)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Hypoglycemic Agents : CK(9221) : AC(2076)

The protective effect of curcumin to PTU-induced hepatotoxicity is attributed to its antioxidative properties.

Pubmed Data : Food Chem Toxicol. 2018 Oct 24 ;123:169-180. Epub 2018 Oct 24. PMID: 30367912
Article Published Date : Oct 23, 2018
Authors : Suresh Kumar Bunker, Abinash Dutta, Jyotsnarani Pradhan, Jagneshwar Dandapat, G B N Chainy
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Graves Disease : CK(175) : AC(28), Hyperthyroidism : CK(264) : AC(55)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Epigenetic Modification : CK(586) : AC(216)

The synergistic hepatoprotective activity of rosemary essential oil and curcumin.

Pubmed Data : Molecules. 2022 Dec 15 ;27(24). Epub 2022 Dec 15. PMID: 36558044
Article Published Date : Dec 14, 2022
Authors : Maged E Mohamed, Nancy S Younis, Hossam S El-Beltagi, Omar M Mohafez
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Rosemary : CK(555) : AC(211)
Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Liver Damage: Drug-Induced : CK(651) : AC(285)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Essential Oils : CK(1005) : AC(429), Natural Substance Synergy : CK(1400) : AC(669)
Problem Substances : Natural Substance Synergy : CK(1400) : AC(669), Paracetamol : CK(863) : AC(298)

Theracurmin has the ability to control lipid metabolism and can potentially serve as an effective therapeutic remedy for the prevention of fatty liver.

Pubmed Data : Toxicol Res. 2019 Oct ;35(4):403-410. Epub 2019 Oct 15. PMID: 31636851
Article Published Date : Sep 30, 2019
Authors : Jin Won Yang, Hee Kyung Yeo, Jee Hye Yun, Jung Un Lee
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Hypolipidemic : CK(9173) : AC(2038)

This review summarizes the existing evidence regarding the potential role of natural antioxidants in the treatment of NAFLD.

Pubmed Data : Liver Int. 2015 Oct 5. Epub 2015 Oct 5. PMID: 26436447
Article Published Date : Oct 04, 2015
Authors : Federico Salomone, Justyna Godos, Shira Zelber-Sagi
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Resveratrol : CK(3228) : AC(1513)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Curcuma longa extract or curcumin has the ability to alleviate the hepatotoxic effects caused by mercuric chloride in rats.

Pubmed Data : Exp Toxicol Pathol. 2017 Mar 20. Epub 2017 Mar 20. PMID: 28336172
Article Published Date : Mar 19, 2017
Authors : Deepmala Joshi, Deepak Kumar Mittal, Sangeeta Shukla, Sunil Kumar Srivastav, Vaibhav A Dixit
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)
Problem Substances : Mercury : CK(889) : AC(215)

Curcumin affects β-catenin pathway in HSCs and might suggest a possible new explanation for the effects of curcumin on HSC activation and liver fibrosis.

Pubmed Data : J Pharm Pharmacol. 2014 Nov ;66(11):1615-22. Epub 2014 Jun 19. PMID: 24945564
Article Published Date : Oct 31, 2014
Authors : Lei Cui, Xin Jia, Qian Zhou, Xuguang Zhai, Yajun Zhou, Huixia Zhu
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cirrhosis : CK(919) : AC(230)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831), Wnt/β-catenin signaling pathway modulation : CK(330) : AC(224)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Turmeric protects against iron-induced lipid peroxidation in the rat liver.

Pubmed Data : Food Chem Toxicol. 1994 Mar;32(3):279-83. PMID: 8157223
Article Published Date : Mar 01, 1994
Authors : A C Reddy, B R Lokesh
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Turmeric : CK(9427) : AC(3904)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Lipid Peroxidation : CK(2057) : AC(806)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Accumulating data shows that curcumin plays a critical role in combating liver fibrogenesis.

Pubmed Data : Dig Dis Sci. 2015 Jun ;60(6):1554-64. Epub 2014 Dec 23. PMID: 25532502
Article Published Date : May 31, 2015
Authors : Youcai Tang
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Risk Reduction : CK(17935) : AC(2006)

The effect of curcumin phytosome on the treatment of patients with non-alcoholic fatty liver disease.

Pubmed Data : Adv Exp Med Biol. 2021 ;1308:25-35. PMID: 33861434
Article Published Date : Dec 31, 2020
Authors : Seyed Reza Mirhafez, Mohsen Azimi-Nezhad, Maryam Dehabeh, Mitra Hariri, Ronika Danesh Naderan, Ali Movahedi, Mohammed Abdalla, Thozhukat Sathyapalan, Amirhossein Sahebkar
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetes Mellitus: Type 2 : CK(12953) : AC(2579), Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Effects of curcumin supplementation on vitamin D levels in women with premenstrual syndrome and dysmenorrhea.

Pubmed Data : BMC Complement Med Ther. 2022 Jan 22 ;22(1):19. Epub 2022 Jan 22. PMID: 35065636
Article Published Date : Jan 21, 2022
Authors : Leyla Arabnezhad, Mahtab Mohammadifard, Ladan Rahmani, Zahra Majidi, Gordon A Ferns, Afsane Bahrami
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Vitamin D : CK(11762) : AC(1712)
Diseases : Dysmenorrhea : CK(1027) : AC(109)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Curcumin alleviates high-fat diet-induced hepatic steatosis and obesity.

Pubmed Data : Food Res Int. 2021 May ;143:110270. Epub 2021 Mar 9. PMID: 33992371
Article Published Date : Apr 30, 2021
Authors : Shuo Li, Jinming You, Zirui Wang, Yue Liu, Bo Wang, Min Du, Tiande Zou
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : High Fat Diet : CK(2040) : AC(984), Liver Steatosis : CK(180) : AC(79), Obesity : CK(11004) : AC(2672)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Anti-Obesity Agents : CK(5172) : AC(1320)

Curcumin protected against the development of hepatic steatosis by reducing hepatic fat accumulation.

Pubmed Data : Basic Clin Pharmacol Toxicol. 2013 Sep ;113(3):152-7. Epub 2013 May 25. PMID: 23574662
Article Published Date : Aug 31, 2013
Authors : Min Young Um, Kwang Hyun Hwang, Jiyun Ahn, Tae Youl Ha
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Fatty Liver : CK(4309) : AC(1216), Hepatic Steatosis : CK(434) : AC(180), High Fat Diet : CK(2040) : AC(984), Obesity : CK(11004) : AC(2672)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831), Hypolipidemic : CK(9173) : AC(2038)

Hepatic fibroblast growth factor 21 is required for curcumin or resveratrol in exerting their metabolic beneficial effect in male mice.

Pubmed Data : Nutr Diabetes. 2025 Feb 10 ;15(1):4. Epub 2025 Feb 10. PMID: 39929809
Article Published Date : Feb 09, 2025
Authors : Jia Nuo Feng, Weijuan Shao, Lin Yang, Juan Pang, Wenhua Ling, Dinghui Liu, Michael B Wheeler, Housheng Hansen He, Tianru Jin
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Resveratrol : CK(3228) : AC(1513)
Diseases : Metabolic Diseases : CK(1273) : AC(272), Obesity : CK(11004) : AC(2672)
Pharmacological Actions : Gastrointestinal Agents : CK(7657) : AC(2274), Hepatoprotective : CK(8989) : AC(3831)

Curcumin is a potential candidate for prevention and treatment of hepatic fibrosis.

Pubmed Data : Biochem J. 2004 Nov 15;384(Pt 1):149-57. PMID: 15320868
Article Published Date : Nov 15, 2004
Authors : Shizhong Zheng, Anping Chen
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Fibrosis : CK(882) : AC(399)
Pharmacological Actions : Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379), Enzyme Inhibitors : CK(846) : AC(399), Hepatoprotective : CK(8989) : AC(3831)

Curcumin may play a role in suppressing hepatic fibrinogenesis.

Pubmed Data : Lab Invest. 2008 May;88(5):529-40. Epub 2008 Mar 10. PMID: 18332871
Article Published Date : May 01, 2008
Authors : Jianguo Lin, Anping Chen
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Fibrosis : CK(882) : AC(399)
Pharmacological Actions : Antiproliferative : CK(10001) : AC(7491), Enzyme Inhibitors : CK(846) : AC(399), Hepatoprotective : CK(8989) : AC(3831)

Curcumin has a prophylactic effect on hepatic fibrosis.

Pubmed Data : Zhonghua Gan Zang Bing Za Zhi. 2006 May;14(5):337-40. PMID: 16732906
Article Published Date : May 01, 2006
Authors : Ya-jun He, Jian-chang Shu, Xia Lü, Li Fang, Yan Sheng
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Fibrosis : CK(882) : AC(399)
Pharmacological Actions : Anti-Fibrotic : CK(2209) : AC(1052), Apoptotic : CK(9585) : AC(7379), Enzyme Inhibitors : CK(846) : AC(399), Hepatoprotective : CK(8989) : AC(3831)

Curcumin induces recovery from hepatic injury.

Pubmed Data : Indian J Biochem Biophys. 2008 Oct;45(5):317-25. PMID: 19069843
Article Published Date : Oct 01, 2008
Authors : S Priya, P R Sudhakaran
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Liver Fibrosis : CK(882) : AC(399)
Pharmacological Actions : Apoptotic : CK(9585) : AC(7379), Hepatoprotective : CK(8989) : AC(3831)

Curcumin protects against acetaminophen-induced toxicity.

Pubmed Data : Curr Neurovasc Res. 2012 Jan 16. Epub 2012 Jan 16. PMID: 22272768
Article Published Date : Jan 16, 2012
Authors : Elida Bulku, Sidney J Stohs, Lorraine Cicero, Tracy Brooks, Herb Halley, Sidhartha D Ray
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Chemically-Induced Liver Damage : CK(2304) : AC(1089)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Apoptotic : CK(9585) : AC(7379), Hepatoprotective : CK(8989) : AC(3831)

Curcumin reduces the programmed cell death associated with toxic bile acids in liver injury during cholestasis.

Pubmed Data : Biochem Biophys Res Commun. 2006 Feb 17;340(3):800-6. Epub 2005 Dec 20. PMID: 16380075
Article Published Date : Feb 17, 2006
Authors : Carina Bernt, Timo Vennegeerts, Ulrich Beuers, Christian Rust
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cholestasis : CK(163) : AC(53)
Pharmacological Actions : Apoptotic : CK(9585) : AC(7379), Enzyme Inhibitors : CK(846) : AC(399), Hepatoprotective : CK(8989) : AC(3831)

Synergistic therapy with celastrol-curcumin multifunctional nanomedicine: Anti-hepatocellular carcinoma and reduced hepatotoxicity.

Pubmed Data : Int J Pharm. 2025 Feb 25 ;671:125289. Epub 2025 Jan 27. PMID: 39880142
Article Published Date : Feb 24, 2025
Authors : Yushi Liu, Jiawen Song, Yurou Guo, Sihui Li, Minghao Yuan, Jiamei Tang, Yulu Wang, Meifeng Li, Yiping Guo, Li Guo
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Celastrol : CK(213) : AC(133), Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Apoptotic : CK(9585) : AC(7379), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Natural Substance Synergy : CK(1400) : AC(669)

Effect of moderate exercises and curcumin on hepatic transcriptional factors associated with lipid metabolism and steatosis in elderly male rat.

Pubmed Data : Res Pharm Sci. 2021 Jun ;16(3):294-304. Epub 2021 May 12. PMID: 34221063
Article Published Date : May 31, 2021
Authors : Minoo Shirpoor, Asghar Tofighi, Alireza Shirpoor, Masoumeh Pourjabali, Leila Chodari
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Dyslipidemias : CK(1626) : AC(329), Liver Steatosis : CK(180) : AC(79)
Therapeutic Actions : Exercise : CK(6919) : AC(1026)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831), Hypolipidemic : CK(9173) : AC(2038)

Hyperlipidemia-induced lipotoxicity and immune activation in rats are prevented by curcumin and rutin.

Pubmed Data : Int Immunopharmacol. 2020 Jan 30 ;81:106217. Epub 2020 Jan 30. PMID: 32007794
Article Published Date : Jan 29, 2020
Authors : Alessandra G Manzoni, Daniela F Passos, Jossiele W Leitemperger, Tamiris R Storck, Pedro H Doleski, Matheus H Jantsch, Vania L Loro, Daniela B R Leal
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Rutin : CK(463) : AC(223)
Diseases : Hyperlipidemia : CK(2140) : AC(553)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831), Hypolipidemic : CK(9173) : AC(2038), Renoprotective : CK(4544) : AC(1971)

Short-term supplementation with Curcumin led to an improvement in different features of NAFLD.

Pubmed Data : Phytother Res. 2016 Jun 8. Epub 2016 Jun 8. PMID: 27270872
Article Published Date : Jun 07, 2016
Authors : Sepideh Rahmani, Sedigheh Asgary, Gholamreza Askari, Mahtab Keshvari, Mahdi Hatamipour, Awat Feizi, Amirhossein Sahebkar
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831), Hypolipidemic : CK(9173) : AC(2038)
Additional Keywords : Significant Treatment Outcome : CK(4297) : AC(505)

This study suggested beneficial effects of combined curcuminoids and piperine supplementation on disease severity in patients with NAFLD.

Pubmed Data : J Cell Biochem. 2019 Sep ;120(9):15989-15996. Epub 2019 Jun 6. PMID: 31168845
Article Published Date : Aug 31, 2019
Authors : Yunes Panahi, Ghasem Valizadegan, Nobakht Ahamdi, Shiva Ganjali, Muhammed Majeed, Amirhossein Sahebkar
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Piperine : CK(600) : AC(258)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831), Hypolipidemic : CK(9173) : AC(2038)

A combination strategy of thymoquinone and curcumin might be considered as a potential antidote in combating liver injury induced by acetaminophen.

Pubmed Data : Folia Morphol (Warsz). 2019 Mar 5. Epub 2019 Mar 5. PMID: 30835338
Article Published Date : Mar 04, 2019
Authors : Muhammad Atteya, Aly Mohamed Ahmed, Amal AlRabiah, Tahani Ahmad Al-Matrafi, Maha M Arafah, Samar Al-Saggaf, Sahar Hussein Shereef, Abdul-Aziz Haji Ahmed, Hamad Mohammed Alqahtani, Raeesa Abdel Tawab Mohammad
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Thymoquinone : CK(1178) : AC(692)
Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)
Problem Substances : Hepatoprotective : CK(8989) : AC(3831), Paracetamol : CK(863) : AC(298)

A curcumin-phospholipid complex works synergistically to protect the livers of rats following chemical exposure.

Pubmed Data : Int J Pharm. 2007 Feb 7;330(1-2):155-63. Epub 2006 Sep 23. PMID: 17112692
Article Published Date : Feb 07, 2007
Authors : Kuntal Maiti, Kakali Mukherjee, Arunava Gantait, Bishnu Pada Saha, Pulok K Mukherjee
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Phosphatidylcholine : CK(112) : AC(24)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Ameliorative effect of curcumin on hepatotoxicity induced by chloroquine phosphate.

Pubmed Data : Environ Toxicol Pharmacol. 2010 Sep ;30(2):103-9. Epub 2010 May 20. PMID: 21787638
Article Published Date : Aug 31, 2010
Authors : J J Dattani, D K Rajput, N Moid, H N Highland, L B George, K R Desai
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Anti-Malarial Drug Toxicity : CK(7) : AC(4), Malaria : CK(303) : AC(135)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)
Problem Substances : Chloroquine phosphate (CQ) : CK(2) : AC(1)

Beneficial effects of curcumin supplementation were observed in decreasing disease activity scores and severity of cirrhosis in patients with cirrhosis.

Pubmed Data : Phytother Res. 2020 Feb 3. Epub 2020 Feb 3. PMID: 32017253
Article Published Date : Feb 02, 2020
Authors : Masoud Nouri-Vaskeh, Aida Malek Mahdavi, Hossein Afshan, Leila Alizadeh, Mohammad Zarei
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cirrhosis : CK(826) : AC(225)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Combination of pomegranate extract and curcumin ameliorates thioacetamide-induced liver fibrosis.

Pubmed Data : Toxicol Mech Methods. 2020 Jul 27:1-23. Epub 2020 Jul 27. PMID: 32718261
Article Published Date : Jul 26, 2020
Authors : Ayah M H Gowifel, Mona G Khalil, Somaia A Nada, Sanaa A Kenawy, Kawkab A Ahmed, Maha M Salama, Marwa M Safar
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Pomegranate : CK(1800) : AC(573)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Liver Fibrosis : CK(882) : AC(399)
Pharmacological Actions : Anti-Fibrotic : CK(2209) : AC(1052), Hepatoprotective : CK(8989) : AC(3831)

Curcumin alleviates ethanol-induced oxidative damage in liver cells.

Pubmed Data : J Ethnopharmacol. 2010 Jan 18. Epub 2010 Jan 18. PMID: 20080166
Article Published Date : Jan 18, 2010
Authors : Wei Bao, Ke Li, Shuang Rong, Ping Yao, Liping Hao, Chenjiang Ying, Xiping Zhang, Andreas Nussler, Liegang Liu
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alcohol Toxicity : CK(1235) : AC(480), Alcoholic Liver Disease : CK(611) : AC(283)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Curcumin ameliorates aflatoxin-induced changes in SDH and ATPase activities in liver and kidney of mice.

Pubmed Data : Acta Pol Pharm. 2008 Jul-Aug;65(4):415-9. PMID: 19051581
Article Published Date : Jul 01, 2008
Authors : Ramtej J Verma, Bhaswat S Chakraborty, Chintan Patel, Neeta Mathuria
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aflatoxicosis : CK(301) : AC(109), Liver Damage: Aflatoxin-Induced : CK(104) : AC(48)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831), Renoprotective : CK(4544) : AC(1971)

Curcumin and andrographolide co-administration safely prevent steatosis induction and ROS production in HepG2 cell line.

Pubmed Data : Molecules. 2023 Jan 27 ;28(3). Epub 2023 Jan 27. PMID: 36770927
Article Published Date : Jan 26, 2023
Authors : Rosaria Maria Pipitone, Rossella Zito, Giulia Lupo, Ayesha Javed, Claudia La Mantia, Gabriele Di Maria, Giovanni Pratelli, Francesca Di Salvo, Simona Fontana, Marzia Pucci, Daniela Carlisi, Stefania Grimaudo
Study Type : In Vitro Study
Additional Links
Substances : Andrographis : CK(432) : AC(202), Curcumin : CK(7239) : AC(3319)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Curcumin attenuated Alcoholic liver disease by modulating lipid deposition in hepatocytes via a Nrf2/FXR activation-dependent mechanism.

Pubmed Data : IUBMB Life. 2015 Aug ;67(8):645-58. Epub 2015 Aug 25. PMID: 26305715
Article Published Date : Jul 31, 2015
Authors : Chunfeng Lu, Feng Zhang, Wenxuan Xu, Xiafei Wu, Naqi Lian, Huanhuan Jin, Qin Chen, Lianyun Chen, Jiangjuan Shao, Li Wu, Yin Lu, Shizhong Zheng
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alcoholic Liver Disease : CK(611) : AC(283), Hepatic Steatosis : CK(434) : AC(180)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831), Nrf2 activation : CK(3156) : AC(1794)

Curcumin could modulate hepatocyte epithelial-mesenchymal transition implicated in treatment of liver fibrosis.

Pubmed Data : Lab Invest. 2015 Aug 24. Epub 2015 Aug 24. PMID: 26302188
Article Published Date : Aug 23, 2015
Authors : Desong Kong, Feng Zhang, Jiangjuan Shao, Li Wu, Xiaoping Zhang, Li Chen, Yin Lu, Shizhong Zheng
Study Type : Human In Vitro
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Liver Fibrosis : CK(882) : AC(399)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Curcumin could protect against the synergistic toxicity of ethanol and atrazine.

Pubmed Data : Ren Fail. 2017 Nov ;39(1):588-596. PMID: 28741978
Article Published Date : Oct 31, 2017
Authors : Sunny O Abarikwu, Queen C Duru, Rex-Clovis C Njoku, Benjamin A Amadi, Aseme Tamunoibuomie, Enebimoere Keboh
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alcohol Toxicity : CK(1235) : AC(480), Pesticide Toxicity : CK(1467) : AC(478)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831), Renoprotective : CK(4544) : AC(1971)
Additional Keywords : Synergistic Toxicity : CK(244) : AC(119)
Problem Substances : Ethanol : CK(27) : AC(12), Pesticides : CK(2401) : AC(488)

Curcumin effectively protects against zinc oxide nanoparticle induced hepatotoxicity in rats.

Pubmed Data : Balkan Med J. 2016 May ;33(3):252-7. Epub 2016 May 1. PMID: 27308068
Article Published Date : Apr 30, 2016
Authors : Layasadat Khorsandi, Esrafil Mansouri, Mahmoud Orazizadeh, Zahra Jozi
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)
Problem Substances : Nanoparticles : CK(467) : AC(297)

Curcumin eliminates oxidized LDL roles in activating hepatic stellate cells which are associated wtih liver fibrosis.

Pubmed Data : Lab Invest. 2009 Nov;89(11):1275-90. Epub 2009 Sep 7. PMID: 19736547
Article Published Date : Nov 01, 2009
Authors : Qiaohua Kang, Anping Chen
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Cholesterol: Oxidation : CK(654) : AC(159), Liver Fibrosis : CK(882) : AC(399)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Curcumin exhibits liver-protective properties against alcohol cytotoxicity.

Pubmed Data : J Ethnopharmacol. 2004 Nov;95(1):31-7. PMID: 15374604
Article Published Date : Nov 01, 2004
Authors : R S Naik, A M Mujumdar, Saroj Ghaskadbi
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alcohol Toxicity : CK(1235) : AC(480)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Curcumin has a liver protecting effect against aflatoxin B(1)-induced liver injury.

Pubmed Data : Arch Toxicol. 2010 May;84(5):389-96. Epub 2010 Jan 30. PMID: 20112103
Article Published Date : May 01, 2010
Authors : Dina S El-Agamy
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Aflatoxicosis : CK(301) : AC(109), Liver Damage: Aflatoxin-Induced : CK(104) : AC(48)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Stilbenes : CK(406) : AC(244)

Curcumin has a protective effect against nicotine-induced genotoxicity on rat liver.

Pubmed Data : Eur J Pharmacol. 2008 Jul 7;588(2-3):151-7. Epub 2008 Apr 15. PMID: 18508046
Article Published Date : Jul 07, 2008
Authors : Gargi Bandyopadhyaya, Surajit Sinha, Braja Dulal Chattopadhyay, Anindita Chakraborty
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), DNA damage : CK(2301) : AC(842), Nicotine/Tobacco Toxicity : CK(273) : AC(108)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Curcumin has potent liver preservation properties in an isolated perfusion model.

Pubmed Data : Transplantation. 2006 Oct 15;82(7):931-7. PMID: 17038909
Article Published Date : Oct 15, 2006
Authors : Changguo Chen, Thomas D Johnston, Guanghan Wu, Dinesh Ranjan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Organ Transplantation: Liver : CK(187) : AC(30)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Curcumin has potential for hepatic fibrosis therapy.

Pubmed Data : J Clin Rheumatol. 2010 Feb 2. Epub 2010 Feb 2. PMID: 18037917
Article Published Date : Feb 02, 2010
Authors : M A O'Connell, S A Rushworth
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Fibrosis : CK(882) : AC(399)
Pharmacological Actions : Anti-Fibrotic : CK(2209) : AC(1052), Hepatoprotective : CK(8989) : AC(3831)

Curcumin has therapeutic value in the prevention and treatment of liver diseases or damage.

Pubmed Data : Liver Int. 2009 Nov;29(10):1457-66. PMID: 19811613
Article Published Date : Nov 01, 2009
Authors : Yadira Rivera-Espinoza, Pablo Muriel
Study Type : Review
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alcoholic Liver Disease : CK(611) : AC(283), Chemically-Induced Liver Damage : CK(2304) : AC(1089), Liver Diseases : CK(62) : AC(19)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Curcumin inhibits LDL cholesterol induced hepatic stellate cell activation associated with fatty liver and liver fibrosis.

Pubmed Data : Endocrinology. 2009 Dec;150(12):5384-94. Epub 2009 Oct 6. PMID: 19808779
Article Published Date : Dec 01, 2009
Authors : Qiaohua Kang, Anping Chen
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Fatty Liver : CK(4309) : AC(1216), High Cholesterol : CK(3091) : AC(530), Liver Fibrosis : CK(882) : AC(399)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Curcumin inhibits lipid peroxidation and cholesterol levels in mice.

Pubmed Data : Indian J Physiol Pharmacol. 1992 Oct;36(4):239-43. PMID: 1291474
Article Published Date : Oct 01, 1992
Authors : K K Soudamini, M C Unnikrishnan, K B Soni, R Kuttan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide : CK(519) : AC(248), Lipid Peroxidation : CK(2057) : AC(806)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Curcumin inhibits radiation-induced changes in the liver.

Pubmed Data : J Radiol Prot. 2001 Dec;21(4):361-70. PMID: 11787891
Article Published Date : Dec 01, 2001
Authors : P Varadkar, P Dubey, M Krishna, N Verma
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Ellagic Acid : CK(540) : AC(294), Quercetin : CK(1876) : AC(855)
Diseases : Radiation Induced Illness : CK(1352) : AC(366)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831), Protein Kinase Inhibitors : CK(32) : AC(21), Radioprotective : CK(2398) : AC(713)

Curcumin may reverse liver fibrosis by epigenetic mechanisms.

Pubmed Data : Chin J Nat Med. 2016 Apr ;14(4):255-64. PMID: 27114312
Article Published Date : Mar 31, 2016
Authors : Peng Wu, Rui Huang, Ya-Li Xiong, Chao Wu
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Fibrosis : CK(882) : AC(399)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : DNA Methylation : CK(384) : AC(78)

Curcumin pretreatment may have clinical potential in hepatic transplantation.

Pubmed Data : Transplantation. 2006 Feb 27;81(4):623-6. PMID: 16495813
Article Published Date : Feb 27, 2006
Authors : Stephen J McNally, Ewen M Harrison, James A Ross, O James Garden, Stephen J Wigmore
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Organ Transplantation: Liver : CK(187) : AC(30)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Curcumin prevented high-fructose induced hyperlipidemia and hepatic steatosis.

Pubmed Data : Pharm Biol. 2016 May 30:1-7. Epub 2016 May 30. PMID: 27241764
Article Published Date : May 29, 2016
Authors : Nachimuthu Maithilikarpagaselvi, Magadi Gopalakrishna Sridhar, Rathinam Palamalai Swaminathan, Ramalingam Sripradha, Bhawana Badhe
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Hepatic Steatosis : CK(434) : AC(180), High Fructose Diet : CK(474) : AC(187), Hyperlipidemia : CK(2140) : AC(553)
Pharmacological Actions : Enzyme Inhibitors : CK(846) : AC(399), Hepatoprotective : CK(8989) : AC(3831)

Curcumin prevented the development of immunological alterations in NAFLD.

Pubmed Data : PLoS One. 2017 ;12(3):e0172900. Epub 2017 Mar 3. PMID: 28257515
Article Published Date : Dec 31, 2016
Authors : María Eugenia Inzaugarat, Elena De Matteo, Placida Baz, Diego Lucero, Cecilia Claudia García, Esteban Gonzalez Ballerga, Jorge Daruich, Juan Antonio Sorda, Miriam Ruth Wald, Alejandra Claudia Cherñavsky
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Curcumin prevents fructose-induced hepatic steatosis driven by hepatic insulin and leptin resistance.

Pubmed Data : Hepatology. 2010 May;51(5):1555-66. PMID: 20222050
Article Published Date : May 01, 2010
Authors : Jian-Mei Li, Yu-Cheng Li, Ling-Dong Kong, Qing-Hua Hu
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Fatty Liver : CK(4309) : AC(1216), Insulin Resistance : CK(4864) : AC(1098), Leptin Resistance : CK(21) : AC(9)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Curcumin prevents paracetamol-induced liver mitochondrial alterations.

Pubmed Data : J Pharm Pharmacol. 2016 Jan 15. Epub 2016 Jan 15. PMID: 26773315
Article Published Date : Jan 14, 2016
Authors : Luis Fernando Granados-Castro, Daniela Sarai Rodríguez-Rangel, Berenice Fernández-Rojas, Juan Carlos León-Contreras, Rogelio Hernández-Pando, Omar Noel Medina-Campos, Dianelena Eugenio-Pérez, Enrique Pinzón, José Pedraza-Chaverri
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)
Problem Substances : Hepatoprotective : CK(8989) : AC(3831), Paracetamol : CK(863) : AC(298)

Curcumin prevents the NASH by mitochondria protection and apoptosis reduction and provided a possible novel treatment for NASH.

Pubmed Data : Int J Clin Exp Pathol. 2015 ;8(9):11503-9. Epub 2015 Sep 1. PMID: 26617882
Article Published Date : Dec 31, 2014
Authors : Long Wang, Yisong Lv, Huixiang Yao, Li Yin, Jianhui Shang
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Hepatoprotective : CK(8989) : AC(3831)

Curcumin protects against alcohol and oxidized fat-induced liver toxicity.

Pubmed Data : Ital J Biochem. 2004 Jul;53(2):61-6. PMID: 15646009
Article Published Date : Jul 01, 2004
Authors : Rajagopalan Rukkumani, Kode Aruna, Penumathsa Suresh Varma, Venugopal Padmanabhan Menon
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alcohol Toxicity : CK(1235) : AC(480), Chemically-Induced Liver Damage : CK(2304) : AC(1089)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(944) : AC(588)

Curcumin protects against bisphenol A-induced hepatic steatosis.

Pubmed Data : Food Sci Nutr. 2023 Sep ;11(9):5091-5101. Epub 2023 Jun 1. PMID: 37701206
Article Published Date : Aug 31, 2023
Authors : Ting Hong, Jun Zou, Jie Yang, Hao Liu, Zhuo Cao, Youming He, Dan Feng
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Bisphenol Toxicity : CK(4416) : AC(1329), Liver Steatosis : CK(180) : AC(79)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)
Problem Substances : Bisphenol A : CK(4570) : AC(1323)

Curcumin protects against chemically-induced rat liver injury.

Pubmed Data : Int J Cancer. 2005 Mar 20;114(2):190-4. PMID: 10813555
Article Published Date : Mar 20, 2005
Authors : E J Park, C H Jeon, G Ko, J Kim, D H Sohn
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089), Liver Damage : CK(4109) : AC(1872)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Curcumin protects against endotoxin-induced acute liver injury in rats.

Pubmed Data : J Huazhong Univ Sci Technolog Med Sci. 2006;26(6):678-81. PMID: 17357487
Article Published Date : Jan 01, 2006
Authors : Qingquan Lian, Xingwang Li, You Shang, Shanglong Yao, Li Ma, Shengwei Jin
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Endotoxemia : CK(359) : AC(127), Liver Damage : CK(4109) : AC(1872)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Curcumin protects the liver against aflatoxin-induced changes.

Pubmed Data : Poult Sci. 2009 Dec;88(12):2620-7. PMID: 19903961
Article Published Date : Dec 01, 2009
Authors : L P Yarru, R S Settivari, N K S Gowda, E Antoniou, D R Ledoux, G E Rottinghaus
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Damage: Aflatoxin-Induced : CK(104) : AC(48)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Curcumin suppresses prevents pre-cancerous changes in the liver of animals.

Pubmed Data : Nutr Cancer. 2003;45(1):53-9. PMID: 12791505
Article Published Date : Jan 01, 2003
Authors : Yogeshwer Shukla, Annu Arora
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Liver Cancer : CK(3119) : AC(1641)
Pharmacological Actions : Antineoplastic Agents : CK(2235) : AC(1468), Hepatoprotective : CK(8989) : AC(3831)

Curcumin treatment beneficially repaired and regenerated liver tissues of diabetic groups and also redeveloped the liver's microvascular complications.

Pubmed Data : J Med Assoc Thai. 2012 May ;95 Suppl 5:S133-41. PMID: 22934459
Article Published Date : Apr 30, 2012
Authors : Wipapan Khimmaktong, Hattaya Petpiboolthai, Busaba Panyarachun, Vipavee Anupunpisit
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Diabetes: Liver Disease : CK(17) : AC(9)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831), Regenerative : CK(486) : AC(201)
Additional Keywords : Liver Regeneration : CK(103) : AC(44)

Curcumin, silymarin and N-acetylcysteine protect against antitubercular drug-induced hepatotoxicity.

Pubmed Data : Hum Exp Toxicol. 2012 Feb 8. Epub 2012 Feb 8. PMID: 22318308
Article Published Date : Feb 08, 2012
Authors : M Singh, P Sasi, V H Gupta, G Rai, D N Amarapurkar, P P Wangikar
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), NAC (N-acetyl-L-cysteine) : CK(1429) : AC(366), Silymarin : CK(455) : AC(112)
Diseases : Tuberculosis Drug Induced Toxicity : CK(123) : AC(33)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)
Problem Substances : Tubercular Drugs : CK(8) : AC(4)

Curcuminoids may suppress liver inflammation associated with endotoxemia.

Pubmed Data : Shock. 2002 May;17(5):399-403. PMID: 12022761
Article Published Date : May 01, 2002
Authors : Wahyuni Lukita-Atmadja, Yoshiya Ito, Gregory L Baker, Robert S McCuskey
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Endotoxemia : CK(359) : AC(127)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Dietary curcuminoids prevent high-fat diet-induced lipid accumulation in rat liver and epididymal adipose tissue.

Pubmed Data : J Nutr. 2001 Nov;131(11):2932-5. PMID: 11694621
Article Published Date : Nov 01, 2001
Authors : A Asai, T Miyazawa
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Fatty Liver : CK(4309) : AC(1216)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Efficacy of a Peruvian botanical remedy (Sabell A4+) for treating liver disease and protecting gastric mucosal integrity.

Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:5486728. Epub 2019 Oct 24. PMID: 31781272
Article Published Date : Dec 31, 2018
Authors : Mark G Swain, John L Wallace, D Lorne Tyrrell, José Cabanillas, Steven K H Aung, Hongqun Liu, Lindsay Finnie-Carvalho, Grishma Shrestha, Hugh A Semple, Francis H Y Green
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Soursop : CK(77) : AC(56)
Diseases : Liver Disease : CK(367) : AC(117)
Pharmacological Actions : Gastroprotective : CK(1692) : AC(701), Hepatoprotective : CK(8989) : AC(3831)

Encapsulated curcumin enhances intestinal absorption and improves hepatic damage in alcoholic liver disease-induced rats.

Pubmed Data : Prev Nutr Food Sci. 2019 Dec ;24(4):410-417. Epub 2019 Dec 31. PMID: 31915636
Article Published Date : Nov 30, 2019
Authors : Sin Geun Kim, Hyung Joo Suh, Sung Hee Han, Hyun-Sun Lee, Hyo-Won Kim, Hoon Kim
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Alcoholic Liver Disease : CK(611) : AC(283)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Hepatoprotective effect of curcumin against bisphenol A-induced hepatic steatosis.

Pubmed Data : J Nutr Biochem. 2022 Jun 30:109103. Epub 2022 Jun 30. PMID: 35780999
Article Published Date : Jun 29, 2022
Authors : Ting Hong, Xin Jiang, Jun Zou, Jie Yang, Hongmin Zhang, Haiyan Mai, Wenhua Ling, Dan Feng
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Bisphenol Toxicity : CK(4416) : AC(1329), Chemically-Induced Liver Damage : CK(2304) : AC(1089)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Hepatoprotective : CK(8989) : AC(3831)
Problem Substances : Bisphenol A : CK(4570) : AC(1323)

Mechanism of natural drugs on nonalcoholic fatty liver disease.

Pubmed Data : Mini Rev Med Chem. 2021 Apr 5. Epub 2021 Apr 5. PMID: 33820503
Article Published Date : Apr 04, 2021
Authors : Jiao Xie, Ling Li, Lei Zhao
Study Type : Review
Additional Links
Substances : Berberine : CK(2483) : AC(1079), Betulinic acid : CK(254) : AC(178), Curcumin : CK(7239) : AC(3319), Ginsenosides : CK(2640) : AC(1452), Silibinin : CK(460) : AC(231), Wormwood : CK(102) : AC(47)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Results of this clinical trial suggest that short-term treatment with curcumin plus piperine administration improves NAFLD severity.

Pubmed Data : Adv Exp Med Biol. 2021 ;1328:11-19. PMID: 34981468
Article Published Date : Dec 31, 2020
Authors : Seyed Reza Mirhafez, Maryam Dehabeh, Mitra Hariri, Azam Rezaie Farimani, Ali Movahedi, Ronika Danesh Naderan, Tannaz Jamialahmadi, Luis E Simental-Mendía, Amirhossein Sahebkar
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Piperidines : CK(99) : AC(31)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(3451) : AC(969)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Tetrahydrocurcumin protect against chloroquine induced liver toxicity.

Pubmed Data : J Pharm Pharm Sci. 2005;8(1):115-23. Epub 2005 Apr 30. PMID: 15946605
Article Published Date : Jan 01, 2005
Authors : Leelavinothan Pari, D Rosalin Amali
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Chemically-Induced Liver Damage : CK(2304) : AC(1089)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

The improvement of intestinal dysbiosis and hepatic metabolic dysfunction in dextran sulfate sodium-induced colitis.

Pubmed Data : J Gastroenterol Hepatol. 2023 Aug ;38(8):1333-1345. Epub 2023 May 20. PMID: 37210613
Article Published Date : Jul 31, 2023
Authors : Feini Zhou, Ting Mai, Ziren Wang, Zhaolong Zeng, Jingjing Shi, Fan Zhang, Ning Kong, Hao Jiang, Lingnan Guo, Maosheng Xu, Jiangnan Lin
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319)
Diseases : Colitis : CK(1542) : AC(735), Inflammatory Bowel Diseases : CK(3196) : AC(926)
Pharmacological Actions : Gastrointestinal Agents : CK(7657) : AC(2274), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Hepatoprotective : CK(8989) : AC(3831)

Turmeric and curcumin reverse aflatoxin-induced liver damage.

Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 1992 Aug;38(4):353-63. PMID: 1291640
Article Published Date : Aug 01, 1992
Authors : Y Fujiyama-Fujiwara, R Umeda, O Igarashi
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(7239) : AC(3319), Lignans : CK(343) : AC(107)
Diseases : Aflatoxicosis : CK(301) : AC(109), Liver Damage: Aflatoxin-Induced : CK(104) : AC(48)
Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

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