Focused Research Topics Wheat & Diabetes Mellitus: Type 1

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Associated Topics included in this Focused Research

Gliadin Gluten Gluten exorphins Wheat Wheat Germ Agglutinin (WGA)

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View the Evidence
13 Research Articles in Total

Adults with Type 1 diabetes have a higher prevalance of celiac disease associated antibodies.

Pubmed Data : Diabetes Nutr Metab. 2001 Feb;14(1):37-42. PMID: 11345164
Article Published Date : Feb 01, 2001
Authors : E Matteucci, V Cinapri, S Quilici, A Lucchetti, P Mugnaini, O Giampietro
Study Type : Human Study
Additional Links
Diseases : Celiac Disease : CK(1612) : AC(232), Diabetes Mellitus: Type 1 : CK(1130) : AC(301), Diabetes Mellitus: Type 1: Prevention : CK(255) : AC(50)
Additional Keywords : Diseases that are Linked : CK(2335) : AC(304)
Problem Substances : Gliadin : CK(819) : AC(116), Wheat : CK(2775) : AC(335)

Celiac disease prevalance was found to be 3.5% in children with type 1 diabetes.

Pubmed Data : J Pediatr Endocrinol Metab. 1996 Mar;9 Suppl 1:101-11. PMID: 8887160
Article Published Date : Mar 01, 1996
Authors : R Lorini, A Scaramuzza, L Vitali, G d'Annunzio, M A Avanzini, C De Giacomo, F Severi
Study Type : Human Study
Additional Links
Diseases : Celiac Disease : CK(1612) : AC(232), Diabetes Mellitus: Type 1 : CK(1130) : AC(301), Diabetes Mellitus: Type 1: Prevention : CK(255) : AC(50)
Additional Keywords : Diseases that are Linked : CK(2335) : AC(304)
Problem Substances : Gliadin : CK(819) : AC(116)

Gliadin triggered insulinitis in type 1 diabetes associated with celiac disease

Pubmed Data : J Immunol. 2011 Oct 15 ;187(8):4338-46. Epub 2011 Sep 12. PMID: 21911598
Article Published Date : Oct 14, 2011
Authors : Heather J Galipeau, Nestor E Rulli, Jennifer Jury, Xianxi Huang, Romina Araya, Joseph A Murray, Chella S David, Fernando G Chirdo, Kathy D McCoy, Elena F Verdu
Study Type : Animal Study
Additional Links
Diseases : Celiac Disease : CK(1612) : AC(232), Diabetes Mellitus: Type 1 : CK(1130) : AC(301), Enteropathy : CK(28) : AC(6), Insulinitis : CK(2) : AC(1)
Problem Substances : Gliadin : CK(819) : AC(116)

Intolerance to wheat (CD autoantibodies) is higher than background rates in those with Turner syndrome.

Pubmed Data : Clin Exp Immunol. 2009 May;156(2):205-10. Epub 2009 Feb 26. PMID: 19298606
Article Published Date : May 01, 2009
Authors : K H Mortensen, L Cleemann, B E Hjerrild, E Nexo, H Locht, E M Jeppesen, C H Gravholt
Study Type : Human Study
Additional Links
Diseases : Autoimmune Diseases : CK(6629) : AC(1128), Celiac Disease : CK(1612) : AC(232), Diabetes Mellitus: Type 1 : CK(1130) : AC(301), Hypothyroidism : CK(582) : AC(89), Turner Syndrome : CK(10) : AC(1)
Additional Keywords : Diseases that are Linked : CK(2335) : AC(304)
Problem Substances : Wheat : CK(2775) : AC(335)
Adverse Pharmacological Actions : Immunotoxic : CK(294) : AC(52)

The prevalence rate of celiac disease in Libyan children with type 1 diabetes was 10.3%.

Pubmed Data : Diabetes Metab Res Rev. 2003 Jan-Feb;19(1):69-75. PMID: 12592646
Article Published Date : Jan 01, 2003
Authors : Abdelhakim Ashabani, Umaima Abushofa, Suliman Abusrewill, Mahmoud Abdelazez, Ludmila Tucková, Helena Tlaskalová-Hogenová
Study Type : Human Study
Additional Links
Diseases : Celiac Disease : CK(1612) : AC(232), Diabetes Mellitus: Type 1 : CK(1130) : AC(301), Diabetes Mellitus: Type 1: Prevention : CK(255) : AC(50)
Additional Keywords : Diseases that are Linked : CK(2335) : AC(304)
Problem Substances : Gliadin : CK(819) : AC(116)

The habitual consumption of wheat gluten may be a contributing factor in the pathogenesis of type 1 diabetes.

Pubmed Data : Med Hypotheses. 2007;68(3):607-19. Epub 2006 Oct 11. PMID: 17045415
Article Published Date : Jan 01, 2007
Authors : William E Barbeau, Josep Bassaganya-Riera, Raquel Hontecillas
Study Type : Commentary
Additional Links
Diseases : Diabetes Mellitus: Type 1 : CK(1130) : AC(301), Gluten Sensitivity : CK(778) : AC(105)
Additional Keywords : Zonulin : CK(15) : AC(5)
Problem Substances : Gliadin : CK(819) : AC(116), Gluten : CK(1088) : AC(167), Wheat : CK(2775) : AC(335)

Dietary gluten influences the development of type 1 diabetes (T1D).

Pubmed Data : PLoS One. 2012 ;7(3):e33315. Epub 2012 Mar 13. PMID: 22428018
Article Published Date : Jan 01, 2012
Authors : Julie Christine Antvorskov, Petra Fundova, Karsten Buschard, David P Funda
Study Type : Animal Study
Additional Links
Diseases : Autoimmune Diseases : CK(6629) : AC(1128), Diabetes Mellitus: Type 1 : CK(1130) : AC(301)
Problem Substances : Gluten : CK(1088) : AC(167)
Adverse Pharmacological Actions : Diabetogenic : CK(269) : AC(46), Immunotoxic : CK(294) : AC(52)

Dietary gluten alters the balance of proinflammatory and anti-inflammatory cytokines in T cells of BALB/c mice, indicating that gluten may contribute to increased incidence of type 1 diabetes.

Pubmed Data : Immunology. 2012 Aug 22. Epub 2012 Aug 22. PMID: 22913724
Article Published Date : Aug 21, 2012
Authors : Julie C Antvorskov, Petra Fundova, Karsten Buschard, David P Funda
Study Type : Animal Study
Additional Links
Diseases : Diabetes Mellitus: Type 1 : CK(1130) : AC(301), Diabetes Mellitus: Type 1: Prevention : CK(255) : AC(50), Inflammation : CK(3240) : AC(882)
Problem Substances : Gluten : CK(1088) : AC(167)
Adverse Pharmacological Actions : Inflammatory : CK(244) : AC(66)

Dietary gluten reduces the number of intestinal regulatory T cells in mice which may result in loss of self-tolerance and therefore increased risk of type 1 diabetes.

Pubmed Data : Scand J Immunol. 2008 Jun ;67(6):553-9. PMID: 18476878
Article Published Date : Jun 01, 2008
Authors : M Ejsing-Duun, J Josephsen, B Aasted, K Buschard, A K Hansen
Study Type : Animal Study
Additional Links
Diseases : Diabetes Mellitus: Type 1 : CK(1130) : AC(301)
Pharmacological Actions : Interleukin-10 downregulation : CK(128) : AC(45)
Problem Substances : Gluten : CK(1088) : AC(167)
Adverse Pharmacological Actions : Diabetogenic : CK(269) : AC(46), Immunotoxic : CK(294) : AC(52)

Gluten-free diet prevents diabetes in NOD mice.

Pubmed Data : Diabetes Metab Res Rev. 1999 Sep-Oct;15(5):323-7. PMID: 10585617
Article Published Date : Aug 31, 1999
Authors : D P Funda, A Kaas, T Bock, H Tlaskalová-Hogenová, K Buschard
Study Type : Animal Study
Additional Links
Diseases : Diabetes Mellitus: Type 1 : CK(1130) : AC(301), Diabetes Mellitus: Type 1: Prevention : CK(255) : AC(50), Hyperinsulinism : CK(251) : AC(56)
Problem Substances : Gliadin : CK(819) : AC(116), Gluten : CK(1088) : AC(167)
Adverse Pharmacological Actions : Diabetogenic : CK(269) : AC(46), Immunotoxic : CK(294) : AC(52)

Low incidence of spontaneous type 1 diabetes in non-obese diabetic mice raised on gluten-free diets is associated with changes in the intestinal microbiome.

Article Published Date : Dec 31, 2012
Authors : Eric V Marietta, Andres M Gomez, Carl Yeoman, Ashenafi Y Tilahun, Chad R Clark, David H Luckey, Joseph A Murray, Bryan A White, Yogish C Kudva, Govindarajan Rajagopalan
Study Type : Animal Study
Additional Links
Diseases : Diabetes Mellitus: Type 1 : CK(1130) : AC(301)
Therapeutic Actions : Dietary Modification: Wheat/Gluten Free : CK(293) : AC(46)
Problem Substances : Gluten : CK(1088) : AC(167)
Adverse Pharmacological Actions : Diabetogenic : CK(269) : AC(46)

Prevalence of celiac among diabetic patients in comparison to normal population was 8.3% vs. 0.6%.

Pubmed Data : J Res Med Sci. 2011 Mar ;16 Suppl 1:S401-6. PMID: 22247725
Article Published Date : Mar 01, 2011
Authors : Homayoon Bashiri, Aliasghar Keshavarz, Hamid Madani, Ahmadreza Hooshmandi, Shahrzad Bazargan-Hejazi, Alireza Ahmadi
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 1 : CK(1130) : AC(301)
Additional Keywords : Celiac Prevalence : CK(121) : AC(13)
Problem Substances : Gluten : CK(1088) : AC(167)

Remission without insulin therapy on gluten-free diet in a 6-year old boy with type 1 diabetes mellitus.

Pubmed Data : BMJ Case Rep. 2012 ;2012. Epub 2012 Jun 21. PMID: 22729336
Article Published Date : Dec 31, 2011
Authors : Stine Møller Sildorf, Siri Fredheim, Jannet Svensson, Karsten Buschard
Study Type : Human: Case Report
Additional Links
Diseases : Diabetes Mellitus: Type 1 : CK(1130) : AC(301), Diabetes Mellitus: Type 1: Prevention : CK(255) : AC(50)
Therapeutic Actions : Dietary Modification: Wheat/Gluten Free : CK(293) : AC(46)
Additional Keywords : Disease Remission : CK(3) : AC(1)
Problem Substances : Gluten : CK(1088) : AC(167), Wheat : CK(2775) : AC(335)
Adverse Pharmacological Actions : Diabetogenic : CK(269) : AC(46)

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