Focused Research Topics Roundup (herbicide) & Endocrine Disruptor

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Associated Topics included in this Focused Research

Glyphosate Roundup (herbicide)

This document was generated from a Focused Research webpage from GreenMedInfo.com

View the Evidence
11 Research Articles in Total

Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines at exceedingly small concentrations (.5 ppm to 10 ppm).

Pubmed Data : Toxicology. 2009 Aug 21;262(3):184-91. Epub 2009 Jun 17. PMID: 19539684
Article Published Date : Aug 21, 2009
Authors : Céline Gasnier, Coralie Dumont, Nora Benachour, Emilie Clair, Marie-Christine Chagnon, Gilles-Eric Séralini
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage : CK(1017) : AC(387)
Additional Keywords : Estrogen Receptor Beta : CK(25) : AC(12)
Problem Substances : Glyphosate : CK(502) : AC(160), Roundup (herbicide) : CK(502) : AC(160)
Adverse Pharmacological Actions : Cytotoxic : CK(85) : AC(50), Endocrine Disruptor : CK(485) : AC(91), Mutagenic : CK(23) : AC(12)

Both the general health condition and reproductive success of J. multidenatata (fish) could be seriously affected by Roundup.

Pubmed Data : Arch Environ Contam Toxicol. 2012 Jan ;62(1):107-17. Epub 2011 Jun 4. PMID: 21643816
Article Published Date : Dec 31, 2011
Authors : Andrea Cecilia Hued, Sabrina Oberhofer, María de losÁngeles Bistoni
Study Type : Animal Study
Additional Links
Problem Substances : Glyphosate formulations : CK(522) : AC(160), Roundup (herbicide) : CK(502) : AC(160)
Adverse Pharmacological Actions : Aquacidal : CK(2) : AC(1), Endocrine Disruptor : CK(485) : AC(91), Genotoxic : CK(165) : AC(68)

Roundup exposure may adversely affect human reproduction and fetal development in case of contamination.

Pubmed Data : Arch Environ Contam Toxicol. 2007 Jul;53(1):126-33. Epub 2007 May 4. PMID: 17486286
Article Published Date : Jul 01, 2007
Authors : N Benachour, H Sipahutar, S Moslemi, C Gasnier, C Travert, G E Séralini
Study Type : In Vitro Study
Additional Links
Diseases : Endocrine Diseases : CK(14) : AC(4), Prenatal Chemical Exposures : CK(457) : AC(112)
Problem Substances : Glyphosate : CK(502) : AC(160), Roundup (herbicide) : CK(502) : AC(160)
Adverse Pharmacological Actions : Aromatase Disruptor : CK(1) : AC(1), Endocrine Disruptor : CK(485) : AC(91)

Endocrine and toxic effects of Roundup, not just glyphosate, can be observed in mammals, and Roundup adjuvants enhance glyphosate bioavailability and/or bioaccumulation.

Pubmed Data : Environ Health Perspect. 2005 Jun;113(6):716-20. PMID: 15929894
Article Published Date : Jun 01, 2005
Authors : Sophie Richard, Safa Moslemi, Herbert Sipahutar, Nora Benachour, Gilles-Eric Seralini
Study Type : Animal Study
Additional Links
Additional Keywords : Drug-Plant-Vitamin Synergies : CK(965) : AC(266)
Problem Substances : Glyphosate : CK(502) : AC(160)
Adverse Pharmacological Actions : Bioaccumulator : CK(107) : AC(26), Cytotoxic : CK(85) : AC(50), Endocrine Disruptor : CK(485) : AC(91)

Glyphosate herbicides (Roundup) exhibit pre- and postnatal toxicity in rats.

Pubmed Data : Arch Toxicol. 2007 Sep;81(9):665-73. Epub 2007 Jul 19. PMID: 17634926
Article Published Date : Sep 01, 2007
Authors : Eliane Dallegrave, Fabiana D Mantese, Rosemari T Oliveira, Anderson J M Andrade, Paulo R Dalsenter, Augusto Langeloh
Study Type : Animal Study
Additional Links
Diseases : Postnatal Care: Breastfeeding : CK(219) : AC(26), Pregnancy: Environmental Exposures : CK(29) : AC(6), Prenatal Chemical Exposures : CK(457) : AC(112)
Problem Substances : Glyphosate : CK(502) : AC(160), Polyoxyethylene amine : CK(12) : AC(7), Roundup (herbicide) : CK(502) : AC(160)
Adverse Pharmacological Actions : Endocrine Disruptor : CK(485) : AC(91)

Glyphosate pesticide (Roundup) exposure may adversely alter estrogen-related gene expression.

Pubmed Data : Hum Exp Toxicol. 2007 Sep;26(9):747-52. PMID: 17984146
Article Published Date : Sep 01, 2007
Authors : R Hokanson, R Fudge, R Chowdhary, D Busbee
Study Type : In Vitro Study
Additional Links
Diseases : Prenatal Chemical Exposures : CK(457) : AC(112)
Problem Substances : Glyphosate : CK(502) : AC(160), Roundup (herbicide) : CK(502) : AC(160)
Adverse Pharmacological Actions : Endocrine Disruptor : CK(485) : AC(91), Genotoxic : CK(165) : AC(68)

Maternal exposure to agrochemicals (such as glyphosate) during pregnancy induces a variety of functional abnormalities in the specific activity of the enzymes in the studied organs of the pregnant rats and their fetuses.

Pubmed Data : Environ Res. 2001 Mar ;85(3):226-31. PMID: 11237511
Article Published Date : Mar 01, 2001
Authors : J Daruich, F Zirulnik, M S Gimenez
Study Type : Animal Study
Additional Links
Diseases : Prenatal Chemical Exposures : CK(457) : AC(112)
Problem Substances : Glyphosate : CK(502) : AC(160)
Adverse Pharmacological Actions : Endocrine Disruptor : CK(485) : AC(91), Teratogenic : CK(320) : AC(63)

Prepubertal exposure to commercial formulation of the herbicide glyphosate alters testosterone levels and testicular morphology.

Pubmed Data : Arch Toxicol. 2010 Apr;84(4):309-17. Epub 2009 Dec 12. PMID: 20012598
Article Published Date : Apr 01, 2010
Authors : R M Romano, M A Romano, M M Bernardi, P V Furtado, C A Oliveira
Study Type : Human Study
Additional Links
Diseases : Hormonal Disorders: Children : CK(14) : AC(3), Pesticide Toxicity : CK(192) : AC(61), Testosterone: Too Low : CK(433) : AC(78)
Additional Keywords : Environmental Pollutant : CK(59) : AC(30)
Problem Substances : Glyphosate : CK(502) : AC(160), Roundup (herbicide) : CK(502) : AC(160)
Adverse Pharmacological Actions : Endocrine Disruptor : CK(485) : AC(91)

The glyphosate herbicide Roundup exhibits teratogenic potential in rats.

Pubmed Data : Toxicol Lett. 2003 Apr 30;142(1-2):45-52. PMID: 12765238
Article Published Date : Apr 30, 2003
Authors : Eliane Dallegrave, Fabiana DiGiorgio Mantese, Ricardo Soares Coelho, Janaina Drawans Pereira, Paulo Roberto Dalsenter, Augusto Langeloh
Study Type : Animal Study
Additional Links
Diseases : Prenatal Chemical Exposures : CK(457) : AC(112)
Problem Substances : Glyphosate : CK(502) : AC(160), Roundup (herbicide) : CK(502) : AC(160)
Adverse Pharmacological Actions : Endocrine Disruptor : CK(485) : AC(91), Teratogenic : CK(320) : AC(63)

The herbicide Roundup may cause disorder in the morphophysiology of the male genital system of animals.

Pubmed Data : Reprod Toxicol. 2007 Feb;23(2):182-91. Epub 2006 Nov 11. PMID: 17166697
Article Published Date : Feb 01, 2007
Authors : André G Oliveira, Luiz F Telles, Rex A Hess, Germán A B Mahecha, Cleida A Oliveira
Study Type : Animal Study
Additional Links
Diseases : Endocrine Diseases : CK(14) : AC(4), Hormonal Disorders: Children : CK(14) : AC(3)
Problem Substances : Glyphosate : CK(502) : AC(160), Roundup (herbicide) : CK(502) : AC(160)
Adverse Pharmacological Actions : Endocrine Disruptor : CK(485) : AC(91)

This review reveals a coherent body of evidence indicating that GlyBH could be toxic below the regulatory lowest observed adverse effect level for chronic toxic effects.

Pubmed Data : Food Chem Toxicol. 2015 Aug 14. Epub 2015 Aug 14. PMID: 26282372
Article Published Date : Aug 13, 2015
Authors : R Mesnage, N Defarge, J Spiroux de Vendômois, G E Séralini
Study Type : Review
Additional Links
Diseases : Herbicide Toxicity : CK(12) : AC(7)
Problem Substances : Glyphosate : CK(502) : AC(160)
Adverse Pharmacological Actions : Endocrine Disruptor : CK(485) : AC(91)

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