Focused Research Topics Glyphosate formulations & Genotoxic

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Associated Topics included in this Focused Research

Glyphosate Glyphosate formulations Roundup (herbicide)

This document was generated from a Focused Research webpage from GreenMedInfo.com

View the Evidence
16 Research Articles in Total

Fish exposed to a glyphosate-based herbicide undergo DNA damage.

Pubmed Data : Mutat Res. 2012 Mar 18 ;743(1-2):1-9. Epub 2012 Jan 14. PMID: 22266476
Article Published Date : Mar 17, 2012
Authors : S Guilherme, I Gaivão, M A Santos, M Pacheco
Study Type : Animal Study
Additional Links
Diseases : DNA damage : CK(1017) : AC(387), Oxidative Stress : CK(3871) : AC(1382)
Pharmacological Actions : Antioxidants : CK(7529) : AC(2682)
Problem Substances : Glyphosate : CK(502) : AC(160)
Adverse Pharmacological Actions : Aquacidal : CK(2) : AC(1), Genotoxic : CK(165) : AC(68)

Both the general health condition and reproductive success of J. multidenatata (fish) could be seriously affected by Roundup.

Pubmed Data : Arch Environ Contam Toxicol. 2012 Jan ;62(1):107-17. Epub 2011 Jun 4. PMID: 21643816
Article Published Date : Dec 31, 2011
Authors : Andrea Cecilia Hued, Sabrina Oberhofer, María de losÁngeles Bistoni
Study Type : Animal Study
Additional Links
Problem Substances : Glyphosate formulations : CK(522) : AC(160), Roundup (herbicide) : CK(502) : AC(160)
Adverse Pharmacological Actions : Aquacidal : CK(2) : AC(1), Endocrine Disruptor : CK(485) : AC(91), Genotoxic : CK(165) : AC(68)

Glyphosate pesticide (Roundup) exposure may adversely alter estrogen-related gene expression.

Pubmed Data : Hum Exp Toxicol. 2007 Sep;26(9):747-52. PMID: 17984146
Article Published Date : Sep 01, 2007
Authors : R Hokanson, R Fudge, R Chowdhary, D Busbee
Study Type : In Vitro Study
Additional Links
Diseases : Prenatal Chemical Exposures : CK(457) : AC(112)
Problem Substances : Glyphosate : CK(502) : AC(160), Roundup (herbicide) : CK(502) : AC(160)
Adverse Pharmacological Actions : Endocrine Disruptor : CK(485) : AC(91), Genotoxic : CK(165) : AC(68)

Commercial glyphosate herbicides exhibit genotoxicity in fish.

Pubmed Data : Mutagenesis. 2007 Jul;22(4):263-8. Epub 2007 Apr 10. PMID: 17426049
Article Published Date : Jul 01, 2007
Authors : Tolga Cavaş, Serpil Könen
Study Type : Animal Study
Additional Links
Diseases : DNA damage : CK(1017) : AC(387)
Problem Substances : Glyphosate : CK(502) : AC(160), Roundup (herbicide) : CK(502) : AC(160)
Adverse Pharmacological Actions : Genotoxic : CK(165) : AC(68)

Components of the original formulation of Roundup exhibit significant toxicity in five North American anurans (frogs; keystone species).

Pubmed Data : Ecotoxicol Environ Saf. 2012 Apr ;78:128-33. Epub 2011 Dec 3. PMID: 22137360
Article Published Date : Mar 31, 2012
Authors : Lindsay J Moore, Latice Fuentes, John H Rodgers, William W Bowerman, Greg K Yarrow, Wayne Y Chao, William C Bridges
Study Type : Animal Study
Additional Links
Problem Substances : Glyphosate : CK(502) : AC(160)
Adverse Pharmacological Actions : Aquacidal : CK(2) : AC(1), Genotoxic : CK(165) : AC(68)

Cytogenetic damage and induction of pro-oxidant state has been observed in human lymphocytes exposed in vitro to glyphosate.

Pubmed Data : Environ Mol Mutagen. 1998 ;32(1):39-46. PMID: 9707097
Article Published Date : Jan 01, 1998
Authors : M B Lioi, M R Scarfi, A Santoro, R Barbieri, O Zeni, F Salvemini, D Di Berardino, M V Ursini
Study Type : Human In Vitro
Additional Links
Diseases : DNA damage : CK(1017) : AC(387)
Problem Substances : Glyphosate : CK(502) : AC(160)
Adverse Pharmacological Actions : Genotoxic : CK(165) : AC(68)

Environmentally relevant concentrations of Roundup can pose a health risk for fish populations.

Pubmed Data : Mutagenesis. 2010 Sep ;25(5):523-30. Epub 2010 Jul 19. PMID: 20643706
Article Published Date : Aug 31, 2010
Authors : S Guilherme, I Gaivão, M A Santos, M Pacheco
Study Type : Animal Study
Additional Links
Diseases : DNA damage : CK(1017) : AC(387), Lipid Peroxidation : CK(695) : AC(255)
Pharmacological Actions : Antioxidants : CK(7529) : AC(2682)
Problem Substances : Glyphosate : CK(502) : AC(160)
Adverse Pharmacological Actions : Aquacidal : CK(2) : AC(1), Genotoxic : CK(165) : AC(68)

Genotoxic effects of the herbicide Roundup(®) have been observed in the fish species Corydoras paleatus after short-term, environmentally low concentration exposure.

Pubmed Data : Environ Monit Assess. 2012 Jul 22. Epub 2012 Jul 22. PMID: 22821326
Article Published Date : Jul 21, 2012
Authors : Nédia de Castilhos Ghisi, Marta Margarete Cestari
Study Type : Animal Study, Environmental
Additional Links
Diseases : Glyphosate Toxicity : CK(76) : AC(30)
Problem Substances : Glyphosate : CK(502) : AC(160), Glyphosate formulations : CK(522) : AC(160), Roundup (herbicide) : CK(502) : AC(160)
Adverse Pharmacological Actions : Aquacidal : CK(2) : AC(1), Genotoxic : CK(165) : AC(68)

Glyphosate has genotoxic properties.

Pubmed Data : Int J Hyg Environ Health. 2006 Jan ;209(1):15-20. Epub 2005 Aug 29. PMID: 16373198
Article Published Date : Jan 01, 2006
Authors : Katarína Siviková, Ján Dianovskỳ
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage : CK(1017) : AC(387)
Problem Substances : Glyphosate : CK(502) : AC(160)
Adverse Pharmacological Actions : Genotoxic : CK(165) : AC(68)

Glyphosate-based pesticides adversely affect cell cycle regulation at concentrations 500 to 4000 times lower than used in agriculatural applications.

Pubmed Data : Biol Cell. 2004 Apr ;96(3):245-9. PMID: 15182708
Article Published Date : Apr 01, 2004
Authors : Julie Marc, Odile Mulner-Lorillon, Robert Bellé
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage : CK(1017) : AC(387)
Problem Substances : Glyphosate : CK(502) : AC(160)
Adverse Pharmacological Actions : Cell Cycle Inhibitor : CK(3) : AC(1), Cytotoxic : CK(85) : AC(50), Genotoxic : CK(165) : AC(68)

Glyphosphate exhibits genotoxicity in human cells.

Pubmed Data : Biomedica. 2005 Sep;25(3):335-45. PMID: 16276681
Article Published Date : Sep 01, 2005
Authors : Claudia Milena Monroy, Andrea Carolina Cortés, Diana Mercedes Sicard, Helena Groot de Restrepo
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage : CK(1017) : AC(387)
Problem Substances : Glyphosate : CK(502) : AC(160)
Adverse Pharmacological Actions : Genotoxic : CK(165) : AC(68)

Roundup herbicide is more toxic than its constituent parts and is genotoxic in concentrations that concentrations that correspond to a 450-fold dilution of spraying used in agriculture.

Pubmed Data : Arch Toxicol. 2012 Feb 14. Epub 2012 Feb 14. PMID: 22331240
Article Published Date : Feb 14, 2012
Authors : Verena J Koller, Maria Fürhacker, Armen Nersesyan, Miroslav Mišík, Maria Eisenbauer, Siegfried Knasmueller
Study Type : In Vitro Study
Additional Links
Diseases : Cancers: All : CK(14773) : AC(4596), DNA damage : CK(1017) : AC(387)
Problem Substances : Glyphosate : CK(502) : AC(160), Roundup (herbicide) : CK(502) : AC(160)
Adverse Pharmacological Actions : Genotoxic : CK(165) : AC(68)

Roundup is able to induce a dose-dependent formation of DNA adducts in the kidneys and liver of mice.

Pubmed Data : Environ Mol Mutagen. 1998 ;31(1):55-9. PMID: 9464316
Article Published Date : Jan 01, 1998
Authors : M Peluso, A Munnia, C Bolognesi, S Parodi
Study Type : Animal Study
Additional Links
Diseases : DNA damage : CK(1017) : AC(387)
Problem Substances : Roundup (herbicide) : CK(502) : AC(160)
Adverse Pharmacological Actions : Genotoxic : CK(165) : AC(68)

Roundup(®) formulation exhibits genotoxicity in blood cells of fish (Anguilla anguilla).

Pubmed Data : Ecotoxicology. 2012 Jul ;21(5):1381-90. Epub 2012 Apr 8. PMID: 22526921
Article Published Date : Jun 30, 2012
Authors : S Guilherme, M A Santos, C Barroso, I Gaivão, M Pacheco
Study Type : Animal Study
Additional Links
Problem Substances : Glyphosate : CK(502) : AC(160)
Adverse Pharmacological Actions : Aquacidal : CK(2) : AC(1), Genotoxic : CK(165) : AC(68)

The environmental metabolite of glyphosate, Aminomethylphosphonic acid, exhibits genotoxicity.

Pubmed Data : Ecotoxicol Environ Saf. 2009 Mar ;72(3):834-7. Epub 2008 Nov 14. PMID: 19013644
Article Published Date : Mar 01, 2009
Authors : F Mañas, L Peralta, J Raviolo, H García Ovando, A Weyers, L Ugnia, M Gonzalez Cid, I Larripa, N Gorla
Study Type : Human In Vitro
Additional Links
Diseases : DNA damage : CK(1017) : AC(387), Liver Cancer : CK(1235) : AC(462)
Problem Substances : Aminomethylphosphonic acid (AMPA) : CK(37) : AC(17), Glyphosate : CK(502) : AC(160)
Adverse Pharmacological Actions : Clastogenic : CK(6) : AC(2), Genotoxic : CK(165) : AC(68)

There is evidence that there is a genotoxic risk potential associated with exposure to glyphosate in areas where the herbicide is applied.

Pubmed Data : J Toxicol Environ Health A. 2009;72(15-16):986-97. PMID: 19672767
Article Published Date : Jan 01, 2009
Authors : C Bolognesi, G Carrasquilla, S Volpi, K R Solomon, E J P Marshall
Study Type : Human Study
Additional Links
Diseases : DNA damage : CK(1017) : AC(387)
Problem Substances : Glyphosate : CK(502) : AC(160)
Adverse Pharmacological Actions : Genotoxic : CK(165) : AC(68)

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