Cannabinoid Receptors

Name	AC	CK
Breast Cancer	4	9
Glioblastoma	3	8
Cardiovascular Diseases	1	5
Colorectal Cancer	1	5
Inflammation	4	5
Skin Cancer	3	5
Cancers: All	4	4
Cancer Metastasis	2	3
Colon Cancer	2	3
Endocannabinoid System	3	3
Thyroid Cancer	2	3
Acute lymphoblastic leukemia (ALL)	1	2
Aging	1	2
Alcohol Withdrawal	1	2
Bladder Cancer	1	2
Breast Cancer: Metastatic	1	2
Carcinoma: Non-Small-Cell Lung	1	2
Cerebral Ischemia	1	2
Diabetes Mellitus: Type 2	1	2
Lung Cancer	1	2
Lymphoma	2	2
Melanoma	1	2
Osteoporosis	1	2
Oxidative Stress	1	2
Prostate Cancer	2	2
Acne	1	1
Acute T cell Leukemias	1	1
Allergies	1	1
Astrocytoma	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Burkitt Lymphoma	1	1
Dermatitis	1	1
Dry Skin	1	1
Gastrointestinal Diseases	1	1
Gastrointestinal Inflammation	1	1
Glioma	1	1
HIV Infections	1	1
Hepatitis C	1	1
Herpes Simplex Virus Type 2	1	1
Immune Disorders	1	1
Inflammatory Bowel Diseases	1	1
Influenza	1	1
Leukemia	1	1
Lymphoma: Non-Hodgkin	1	1
Prostate: PSA Doubling	1	1
Psoriasis	1	1
Seborrheic Keratosis	1	1
Urinary Bladder Diseases	1	1

Name	AC	CK
Cannabinoids	20	30
Endocannabinoids	7	12
Cannabidiol	5	10
Delta-tetrahydrocannabinol (THC)	6	10
Anandamide	4	9
Cannabinoids: Synthetic	5	9
Black Raspberry	1	2
Olive Oil	1	2

Name	AC	CK	Focus
Electroacupuncture	3	5

Name	AC	CK
Antiproliferative	17	29
Apoptotic	16	23
Anti-metastatic	7	11
Antineoplastic Agents	4	7
Angiogenesis Inhibitors	3	5
Cell cycle arrest	3	5
Vasodilator Agents	1	5
Anti-Inflammatory Agents	4	4
Anticarcinogenic Agents	3	3
Cannabinoid Receptor Antagonist/Inverse Agonist	2	3
Anti-Apoptotic	1	2
Anti-Tumor	1	2
Catalase Up-Regulation	1	2
Chemopreventive	1	2
Chemosensitizer	1	2
Chemotherapeutic	1	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	2
Neuroprotective Agents	1	2
STAT3 Activation	1	2
Superoxide Dismutase Up-regulation	1	2
Tumor Necrosis Factor (TNF) Alpha Inhibitor	1	2
Vascular Endothelial Growth Factor A Inhibitor	1	2
Vascular Endothelial Growth Factor Regulator	1	2
Analgesics	1	1
Anti-Androgen	1	1
Anti-Angiogenic	1	1
Antinoceceptive	1	1
Caspase-3 Activation	1	1
Caspase-8 activation	1	1
Caspase-9 Activation	1	1
Immunomodulatory	1	1
Immunosuppressive Agents	1	1
NADPH Oxidase Inhibitors	1	1
P21 Activation	1	1
Tumor Suppressor Protein p53 Upregulation	1	1

[+]

Anandamide is a potent and selective inhibitor of the proliferation of breast cancer cells.Jul 06, 1998

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Proc Natl Acad Sci U S A. 1998 Jul 7 ;95(14):8375-80. PMID: 9653194

Article Published Date : Jul 06, 1998

Study Type : Human In Vitro

Additional Links

Substances : Anandamide, Cannabinoids

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Cannabinoid Receptors, Dose Response

[+]

Cannabidiol causes vasorelaxation of the human mesenteric artery.Aug 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cardiovasc Res. 2015 Sep 1 ;107(4):568-78. Epub 2015 Jun 19. PMID: 26092099

Article Published Date : Aug 31, 2015

Study Type : Human In Vitro

Additional Links

Substances : Cannabidiol

Diseases : Cardiovascular Diseases

Pharmacological Actions : Vasodilator Agents

Additional Keywords : Cannabinoid Receptors

[+]

Elevated CB2 receptor expression was identified in glioblastoma cells.Jun 29, 2009

Click here to read the entire abstract

Pubmed Data : Brain Res Bull. 2009 Jun 30 ;79(5):333-7. Epub 2009 Feb 6. PMID: 19480992

Article Published Date : Jun 29, 2009

Study Type : Human In Vitro

Additional Links

Diseases : Glioblastoma

Additional Keywords : Cannabinoid Receptors

[+]

Endocannabinoid and ceramide levels are altered in patients with colorectal cancer.Jun 30, 2015

Click here to read the entire abstract

Pubmed Data : Oncol Rep. 2015 Jul ;34(1):447-54. Epub 2015 May 12. PMID: 25975960

Article Published Date : Jun 30, 2015

Study Type : Human In Vitro

Additional Links

Substances : Endocannabinoids

Diseases : Colorectal Cancer

Additional Keywords : Cannabinoid Receptors, Endocannabinoid System

[+]

A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice.May 07, 2017

Click here to read the entire abstract

Pubmed Data : Nat Med. 2017 May 8. Epub 2017 May 8. PMID: 28481360

Article Published Date : May 07, 2017

Study Type : Animal Study

Additional Links

Substances : Delta-tetrahydrocannabinol (THC)

Diseases : Aging: Brain , Cognitive Decline/Dysfunction

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Cannabinoid Receptors

[+]

A synthetic cannabinoid inhibited CXCL12-induced migration and invasive properties of breast cancer cells.Dec 31, 2010

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2011 ;6(9):e23901. Epub 2011 Sep 7. PMID: 21915267

Article Published Date : Dec 31, 2010

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cannabinoids

Diseases : Breast Cancer, Breast Cancer: Metastatic

Pharmacological Actions : Anti-metastatic, Antiproliferative

Additional Keywords : Cannabinoid Receptors, Synthetic Cannabinoids

[+]

Activation of cannabinoid receptors could be a new therapeutic approach for the treatment of skin tumors.Dec 31, 2002

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Clin Invest. 2003 Jan ;111(1):43-50. PMID: 12511587

Article Published Date : Dec 31, 2002

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cannabinoids

Diseases : Skin Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Antineoplastic Agents, Apoptotic, Vascular Endothelial Growth Factor A Inhibitor, Vascular Endothelial Growth Factor Regulator

Additional Keywords : Cannabinoid Receptors

[+]

Beta-caryophyllene constitutes an alluring therapeutic molecule towards the treatment of multiple sclerosis.Mar 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2017 Apr 1 ;18(4). Epub 2017 Apr 1. PMID: 28368293

Article Published Date : Mar 31, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Beta-Caryophyllene

Diseases : Inflammation: Brain, Multiple Sclerosis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Immunomodulatory, Interleukin-1 beta downregulation, Interleukin-6 Downregulation

Additional Keywords : Cannabinoid Receptors

[+]

Beta-caryophyllene could be useful for prevention and treatment of antiretroviral-induced neuropathic pain.Dec 26, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2019 Dec 27 ;25(1). Epub 2019 Dec 27. PMID: 31892132

Article Published Date : Dec 26, 2019

Study Type : Animal Study

Additional Links

Substances : Beta-Caryophyllene

Diseases : HIV Infections, Neuropathic Pain

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Cannabinoid Receptors

[+]

Black raspberry extracts may benefit osteoporotic patients with prostatic disease by simultaneously altering the activation of osteoblasts and osteoclasts.May 31, 2015

Click here to read the entire abstract

Pubmed Data : Aging Male. 2015 Jun ;18(2):124-32. Epub 2014 Aug 19. PMID: 25136745

Article Published Date : May 31, 2015

Study Type : Animal Study

Additional Links

Substances : Black Raspberry

Diseases : Aging, Osteoporosis

Additional Keywords : Cannabinoid Receptors, Plant Extracts

[+]

Cannabidiol enhanced the ability of THC to inhibit cell proliferation, induce cell cycle arrest and apoptosis.Dec 31, 2009

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Cancer Ther. 2010 Jan ;9(1):180-9. Epub 2010 Jan 6. PMID: 20053780

Article Published Date : Dec 31, 2009

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cannabidiol, Delta-tetrahydrocannabinol (THC)

Diseases : Cancer Metastasis, Glioblastoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Cannabinoid Receptors, Natural Substance Synergy

[+]

Cannabinoids inhibit the growth of melanoma cells but not of normal melanocytes.Nov 30, 2006

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : FASEB J. 2006 Dec ;20(14):2633-5. Epub 2006 Oct 25. PMID: 17065222

Article Published Date : Nov 30, 2006

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cannabinoids , Cannabinoids: Synthetic

Diseases : Melanoma

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Chemotherapeutic

Additional Keywords : Cannabinoid Receptors, Selective Cytotoxicity

[+]

Cannabinoids were effective in reducing the tumor load, prolonging the mean survival time as well as curing a significant proportion of mice in this study.Jul 14, 2002

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Blood. 2002 Jul 15 ;100(2):627-34. PMID: 12091357

Article Published Date : Jul 14, 2002

Study Type : Animal Study

Additional Links

Substances : Anandamide, Cannabinoids: Synthetic, Delta-tetrahydrocannabinol (THC)

Diseases : Acute lymphoblastic leukemia (ALL)

Pharmacological Actions : Anti-Tumor, Antineoplastic Agents, Antiproliferative , Apoptotic

Additional Keywords : Cannabinoid Receptors, Significant Treatment Outcome

[+]

Chronic exercise modulates the cellular immunity and its cannabinoid receptors expression.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2019 ;14(11):e0220542. Epub 2019 Nov 18. PMID: 31738771

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Therapeutic Actions : Exercise

Pharmacological Actions : Immunomodulatory

Additional Keywords : Cannabinoid Receptors

[+]

Electroacupuncture inhibits CB1 upregulation induced by ethanol withdrawal in mice.Jun 30, 2012

Click here to read the entire abstract

Pubmed Data : Neurochem Int. 2012 Jul ;61(2):277-85. Epub 2012 May 18. PMID: 22613131

Article Published Date : Jun 30, 2012

Study Type : Animal Study

Additional Links

Diseases : Alcohol Withdrawal

Therapeutic Actions : Electroacupuncture

Additional Keywords : Cannabinoid Receptors

[+]

Electroacupuncture potentiates cannabinoid receptor-mediated descending inhibitory control in a mouse model of knee osteoarthritis.Dec 31, 2017

Click here to read the entire abstract

Pubmed Data : Front Mol Neurosci. 2018 ;11:112. Epub 2018 Apr 6. PMID: 29681797

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Diseases : Osteoarthritis: Knee

Therapeutic Actions : Electroacupuncture

Pharmacological Actions : Antinoceceptive

Additional Keywords : Cannabinoid Receptors

[+]

Electroacupuncture pretreatment enhances STAT3 activation via CB1R to protect against cerebral ischemia.Sep 04, 2013

Click here to read the entire abstract

Pubmed Data : Brain Res. 2013 Sep 5 ;1529:154-64. Epub 2013 Jul 20. PMID: 23880371

Article Published Date : Sep 04, 2013

Study Type : Animal Study

Additional Links

Diseases : Cerebral Ischemia

Therapeutic Actions : Electroacupuncture

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents, STAT3 Activation

Additional Keywords : Cannabinoid Receptors

[+]

Electroacupuncture reduces visceral pain Via cannabinoid CB2 receptors in a mouse model of inflammatory bowel disease.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2022 ;13:861799. Epub 2022 Mar 25. PMID: 35401205

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Diseases : Inflammatory Bowel Diseases

Therapeutic Actions : Electroacupuncture

Additional Keywords : Cannabinoid Receptors

[+]

Extravirgin olive oil up-regulates CB₁ tumor suppressor gene in human colon cancer cells.Feb 28, 2015

Click here to read the entire abstract

Pubmed Data : J Nutr Biochem. 2015 Mar ;26(3):250-8. Epub 2014 Dec 3. PMID: 25533906

Article Published Date : Feb 28, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Olive Oil

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Chemopreventive

Additional Keywords : Cannabinoid Receptors, Endocannabinoid System, Epigenetic Modification In Cancer, Plant Extracts

[+]

Paeoniflorin exerts a neuroprotective effect in model of dementia.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Chin Med. 2018 ;13:14. Epub 2018 Mar 20. PMID: 29560022

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Paeoniflorin

Diseases : Dementia

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Cannabinoid Receptors

[+]

Palmitoylethanolamide attenuates PTZ-induced seizures through CB1 and CB2 receptors.Oct 31, 2015

Click here to read the entire abstract

Pubmed Data : Epilepsy Res. 2015 Nov ;117:23-8. Epub 2015 Aug 14. PMID: 26370914

Article Published Date : Oct 31, 2015

Study Type : Animal Study

Additional Links

Substances : Palmitoylethanolamide

Diseases : Seizures

Pharmacological Actions : Anticonvulsants

Additional Keywords : Cannabinoid Receptors

[+]

Palmitoylethanolamide improves murine experimental colitis.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Br J Pharmacol. 2015 Jan ;172(1):142-58. Epub 2014 Dec 1. PMID: 25205418

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Palmitoylethanolamide

Diseases : Colitis

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Cannabinoid Receptors

[+]

Synthetic cannabinoids inhibited growth, migration and invasion of NSCLC cells in in vitro as well as in vivo in a mouse model.Dec 31, 2010

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Prev Res (Phila). 2011 Jan ;4(1):65-75. Epub 2010 Nov 19. PMID: 21097714

Article Published Date : Dec 31, 2010

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cannabinoids: Synthetic

Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Matrix metalloproteinase-9 (MMP-9) inhibitor

Additional Keywords : Cannabinoid Receptors

[+]

THC may provide a protective effect against oxidative damage induced by diabetes.Sep 30, 2014

Click here to read the entire abstract

Pubmed Data : Cell Biochem Funct. 2014 Oct ;32(7):612-9. Epub 2014 Sep 3. PMID: 25187240

Article Published Date : Sep 30, 2014

Study Type : Animal Study

Additional Links

Substances : Delta-tetrahydrocannabinol (THC)

Diseases : Diabetes Mellitus: Type 2, Oxidative Stress

Pharmacological Actions : Catalase Up-Regulation, Superoxide Dismutase Up-regulation

Additional Keywords : Cannabinoid Receptors

[+]

The discovery of IL-12-induced CB2 overexpression in thyroid cancer cells may offer a new target for anaplastic thyroid cancer treatmentJan 31, 2008

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Gene Ther. 2008 Feb ;15(2):101-7. Epub 2007 Dec 21. PMID: 18197164

Article Published Date : Jan 31, 2008

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cannabinoids , Cannabinoids: Synthetic

Diseases : Thyroid Cancer

Pharmacological Actions : Apoptotic, Cannabinoid Receptor Antagonist/Inverse Agonist, Chemosensitizer

Additional Keywords : Cannabinoid Receptors, Chemothapeutic Synergy: Paclitaxel

[+]

The in vivo assessment of the role of CB receptors in inflammation and cancer might be instrumental in broadening the understanding about bladder cancer biology.Sep 30, 2015

Click here to read the entire abstract

Pubmed Data : Life Sci. 2015 Oct 1 ;138:41-51. Epub 2014 Oct 15. PMID: 25445433

Article Published Date : Sep 30, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cannabinoids , Endocannabinoids

Diseases : Bladder Cancer, Inflammation

Pharmacological Actions : Antiproliferative , Apoptotic, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Cannabinoid Receptors

[+]

These results confirm the value of exogenous cannabinoids for the treatment of melanomas. Sep 30, 2015

Click here to read the entire abstract

Pubmed Data : Life Sci. 2015 Oct 1 ;138:35-40. Epub 2015 Apr 25. PMID: 25921771

Article Published Date : Sep 30, 2015

Study Type : Animal Study

Additional Links

Substances : Cannabinoids , Delta-tetrahydrocannabinol (THC)

Diseases : Skin Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Cannabinoid Receptors

[+]

Zerumbone ameliorates neuropathic pain symptoms.Jun 23, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2021 Jun 24 ;26(13). Epub 2021 Jun 24. PMID: 34202590

Article Published Date : Jun 23, 2021

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Zerumbone

Diseases : Neuropathic Pain

Pharmacological Actions : Analgesics, Antinoceceptive

Additional Keywords : Cannabinoid Receptors

[+]

β-Caryophyllene, a natural bicyclic sesquiterpene attenuates doxorubicin-induced cardiotoxicity.Mar 01, 2019

Click here to read the entire abstract

Pubmed Data : Chem Biol Interact. 2019 Mar 2. Epub 2019 Mar 2. PMID: 30836069

Article Published Date : Mar 01, 2019

Study Type : Animal Study

Additional Links

Substances : Beta-Caryophyllene

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Chemoprotective Agents

Additional Keywords : Cannabinoid Receptors

[+]

Δ9-tetrahydrocannabinol prevents mortality from acute respiratory distress syndrome.Aug 27, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2020 Aug 28 ;21(17). Epub 2020 Aug 28. PMID: 32872332

Article Published Date : Aug 27, 2020

Study Type : Animal Study

Additional Links

Substances : Delta-tetrahydrocannabinol (THC)

Diseases : Acute Respiratory Distress Syndrome

Pharmacological Actions : MicroRNA modulator

Additional Keywords : Cannabinoid Receptors, Cytokine Modulation, Cytokine Storm

[+]

An analogue of anandamide Met-F-AEA could have significance in providing a basis for the management of thyroid carcinomas.Mar 31, 2010

Click here to read the entire abstract

Pubmed Data : Invest New Drugs. 2010 Apr ;28(2):115-23. Epub 2009 Feb 3. PMID: 19189054

Article Published Date : Mar 31, 2010

Study Type : In Vitro Study

Additional Links

Diseases : Thyroid Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, P21 Activation, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Cannabinoid Receptors

[+]

Beta-caryophyllene administration could be a novel treatment to reduce hyper-inflammation in human sepsis.Dec 31, 2017

Click here to read the entire abstract

Pubmed Data : Med Hypotheses. 2018 Jan ;110:68-70. Epub 2017 Nov 4. PMID: 29317072

Article Published Date : Dec 31, 2017

Study Type : Review

Additional Links

Substances : Beta-Caryophyllene

Diseases : Sepsis

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Cannabinoid Receptors

[+]

Cannabinoid receptor ligands induce decreased viability, growth suppression and cell death by apoptosis in MCL cells.Dec 18, 2005

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : FEBS Lett. 2005 Dec 19 ;579(30):6885-9. PMID: 16337199

Article Published Date : Dec 18, 2005

Study Type : In Vitro Study

Additional Links

Substances : Anandamide, Cannabinoids , Cannabinoids: Synthetic

Diseases : Breast Cancer, Lymphoma

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Cannabinoid Receptors

[+]

Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.Nov 22, 1999

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Proc Natl Acad Sci U S A. 1999 Nov 23 ;96(24):14136-41. PMID: 10570211

Article Published Date : Nov 22, 1999

Study Type : In Vitro Study

Additional Links

Substances : Cannabidiol, Cannabinoids

Diseases : Endothelial Dysfunction

Pharmacological Actions : Vasodilator Agents

Additional Keywords : Cannabinoid Receptors

[+]

Cannabinoids - via direct or indirect activation of CB(1) and/or CB(2) receptors exert protective effects in well-established models of intestinal inflammation and colon cancer.Jul 31, 2009

Click here to read the entire abstract

Pubmed Data : Pharmacol Res. 2009 Aug ;60(2):117-25. Epub 2009 Mar 18. PMID: 19442536

Article Published Date : Jul 31, 2009

Study Type : Review

Additional Links

Substances : Cannabinoids

Diseases : Colon Cancer, Endocannabinoid System, Gastrointestinal Inflammation, Inflammation, Inflammatory Bowel Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents

Additional Keywords : Cannabinoid Receptors

[+]

Cannabinoids are promising candidates for gastrointestinal and urinary diseases.Dec 31, 2014

Click here to read the entire abstract

Pubmed Data : Handb Exp Pharmacol. 2015 ;231:423-47. PMID: 26408170

Article Published Date : Dec 31, 2014

Study Type : Review

Additional Links

Substances : Cannabidiol, Cannabinoids

Diseases : Gastrointestinal Diseases, Urinary Bladder Diseases

Additional Keywords : Cannabinoid Receptors

[+]

Cannabinoids exert anti-inflammatory, anti-proliferative, anti-invasive, anti-metastatic and pro-apoptotic effects in different cancer types.May 31, 2015

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Pubmed Data : Histol Histopathol. 2015 Jun ;30(6):629-45. Epub 2014 Dec 4. PMID: 25472761

Article Published Date : May 31, 2015

Study Type : Review

Additional Links

Substances : Cannabinoids

Diseases : Glioma

Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Antiproliferative , Apoptotic

Additional Keywords : Cannabinoid Receptors

[+]

Cannabinoids have the potential to regulate the activation and balance of human Th1/Th2 cells by a CB2 receptor-dependent pathway.Nov 30, 2002

Click here to read the entire abstract

Pubmed Data : J Neuroimmunol. 2002 Dec ;133(1-2):124-31. PMID: 12446015

Article Published Date : Nov 30, 2002

Study Type : In Vitro Study

Additional Links

Substances : Cannabinoids , Delta-tetrahydrocannabinol (THC)

Diseases : Immune Dysregulation: TH1/TH2 imbalance

Pharmacological Actions : Immunomodulatory

Additional Keywords : Cannabinoid Receptors

[+]

Cannabinoids might be a suitable treatment for rheumatoid arthritis.Apr 30, 2019

Click here to read the entire abstract

Pubmed Data : Curr Opin Rheumatol. 2019 May ;31(3):271-278. PMID: 30920973

Article Published Date : Apr 30, 2019

Study Type : Review

Additional Links

Substances : Cannabidiol

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Cannabinoid Receptors

[+]

Cannabinoids modulate neuronal activity and cancer by CB1 and CB2 receptor-independent mechanisms.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2017 ;8:720. Epub 2017 Oct 10. PMID: 29066974

Article Published Date : Dec 31, 2016

Study Type : Review

Additional Links

Substances : Cannabinoids

Diseases : Cancers: All

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Cannabinoid Receptors

[+]

Cannabinoids possess attributes that have impact in both cancer pain and prostate cancer pathophysiology.Dec 31, 2011

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Indian J Urol. 2012 Jan ;28(1):9-14. PMID: 22557710

Article Published Date : Dec 31, 2011

Study Type : Review

Additional Links

Substances : Cannabinoids

Diseases : Prostate: PSA Doubling, Prostate Cancer

Pharmacological Actions : Analgesics, Anti-Angiogenic

Additional Keywords : Cannabinoid Receptors

[+]

Cannabinoids prevent proliferation and cause apoptosis via a combination of cannabinoid receptor-independent, cellular and molecular mechanisms.Dec 31, 2012

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Br J Pharmacol. 2013 Jan ;168(1):79-102. PMID: 22594963

Article Published Date : Dec 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Cannabidiol, Cannabinoids

Diseases : Prostate Cancer

Pharmacological Actions : Anti-Androgen, Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Cannabinoid Receptors

[+]

CB1 receptor immunoreactivity was significantly lower while CB2 receptor immunoreactivity was significantly greater in the membranes of glioblastoma multiforme and astrocytoma.Apr 30, 2010

Click here to read the entire abstract

Pubmed Data : Neurochem Int. 2010 May-Jun;56(6-7):829-33. Epub 2010 Mar 20. PMID: 20307616

Article Published Date : Apr 30, 2010

Study Type : In Vitro Study

Additional Links

Substances : Cannabinoids

Diseases : Astrocytoma, Glioblastoma

Additional Keywords : Cannabinoid Receptors

[+]

CB2 receptor activation signals apoptosis via a ceramide-dependent stimulation of the mitochondrial intrinsic pathway.Jun 30, 2006

Click here to read the entire abstract

Pubmed Data : Exp Cell Res. 2006 Jul 1 ;312(11):2121-31. Epub 2006 Apr 19. PMID: 16624285

Article Published Date : Jun 30, 2006

Study Type : In Vitro Study

Additional Links

Substances : Cannabinoids , Delta-tetrahydrocannabinol (THC)

Diseases : Acute T cell Leukemias

Pharmacological Actions : Apoptotic

Additional Keywords : Cannabinoid Receptors

[+]

Electroacupuncture increases the CB2 receptor expression on keratinocytes and infiltrating inflammatory cells in inflammatory skin tissues.Nov 30, 2010

Click here to read the entire abstract

Pubmed Data : J Pain. 2010 Dec ;11(12):1250-8. Epub 2010 Jun 2. PMID: 20627823

Article Published Date : Nov 30, 2010

Study Type : In Vitro Study

Additional Links

Diseases : Inflammation

Therapeutic Actions : Electroacupuncture

Pharmacological Actions : Antinoceceptive

Additional Keywords : Cannabinoid Receptors

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In the current study we demonstrated that cannabidiol can induce apoptosis in murine as well as human leukemia cells.Aug 31, 2006

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Pharmacol. 2006 Sep ;70(3):897-908. Epub 2006 Jun 5. PMID: 16754784

Article Published Date : Aug 31, 2006

Study Type : In Vitro Study

Additional Links

Substances : Cannabidiol

Diseases : Leukemia

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation, NADPH Oxidase Inhibitors

Additional Keywords : Cannabinoid Receptors

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The endocannabinoid system controls the growth and metastasis of malignant cells.Apr 30, 2003

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Pubmed Data : Recenti Prog Med. 2003 May ;94(5):194-8. PMID: 12723496

Article Published Date : Apr 30, 2003

Study Type : Review

Additional Links

Substances : Cannabinoids , Delta-tetrahydrocannabinol (THC), Endocannabinoids

Diseases : Cancer Metastasis, Cancers: All, Endocannabinoid System

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic

Additional Keywords : Cannabinoid Receptors

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The experimental evidence reviewed in this article argues in favor of the therapeutic potential of these compounds in immune disorders and cancer.Jan 31, 2002

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Pubmed Data : Prostaglandins Leukot Essent Fatty Acids. 2002 Feb-Mar;66(2-3):319-32. PMID: 12052046

Article Published Date : Jan 31, 2002

Study Type : Review

Additional Links

Substances : Cannabinoids , Endocannabinoids

Diseases : Cancers: All, Endocannabinoid System, Immune Disorders

Pharmacological Actions : Antiproliferative , Apoptotic, Immunosuppressive Agents

Additional Keywords : Cannabinoid Receptors

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The present study reviews current insights into the role of cannabinoids and their receptors on viral infections.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Med Virol. 2016 Jan ;88(1):1-12. Epub 2015 Jun 25. PMID: 26059175

Article Published Date : Dec 31, 2015

Study Type : Review

Additional Links

Substances : Cannabinoids

Diseases : Hepatitis C, Herpes Simplex Virus Type 2, HIV Infections, Influenza

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory

Additional Keywords : Cannabinoid Receptors

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These results show an association between elevated CB2 expression in HER2+ breast tumors and poor patient prognosis.May 31, 2015

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Pubmed Data : J Natl Cancer Inst. 2015 Jun ;107(6):djv077. Epub 2015 Apr 8. PMID: 25855725

Article Published Date : May 31, 2015

Study Type : In Vitro Study

Additional Links

Diseases : Breast Cancer, Breast Cancer: HER-2 Overexpressed

Additional Keywords : Cannabinoid Receptors

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This review critically discusses the pharmacology of CB receptor activation as a novel therapeutic anticancer strategyJun 30, 2009

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Pubmed Data : J Pharm Pharmacol. 2009 Jul ;61(7):839-53. PMID: 19589225

Article Published Date : Jun 30, 2009

Study Type : Review

Additional Links

Substances : Cannabinoids , Endocannabinoids

Diseases : Cancers: All

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Anti-metastatic, Anticarcinogenic Agents, Antineoplastic Agents, Antiproliferative

Additional Keywords : Cannabinoid Receptors, Endocannabinoid System

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This review discusses how the endocannabinoid system can help treat diseases of the skin.Jul 31, 2009

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Trends Pharmacol Sci. 2009 Aug ;30(8):411-20. Epub 2009 Jul 14. PMID: 19608284

Article Published Date : Jul 31, 2009

Study Type : Review

Additional Links

Substances : Endocannabinoids

Diseases : Acne, Allergies, Dermatitis, Dry Skin , Inflammation, Psoriasis, Seborrheic Keratosis, Skin Cancer

Pharmacological Actions : Anticarcinogenic Agents, Cannabinoid Receptor Antagonist/Inverse Agonist

Additional Keywords : Cannabinoid Receptors, Endocannabinoid System

[+]

This review summarises the demonstrated antitumour actions of cannabinoids and indicating possible avenues for cannabinoids as antitumour agents.Nov 30, 2003

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Pubmed Data : Expert Opin Ther Targets. 2003 Dec ;7(6):749-58. PMID: 14640910

Article Published Date : Nov 30, 2003

Study Type : Review

Additional Links

Substances : Cannabinoids , Endocannabinoids

Diseases : Cancers: All

Additional Keywords : Cannabinoid Receptors

[+]

Using cannabinoid receptor ligands will have efficiency in reducing tumor burden in malignant lymphoma overexpressing CB1 and CB2.Aug 31, 2008

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Cancer. 2008 Sep 1 ;123(5):1025-33. PMID: 18546271

Article Published Date : Aug 31, 2008

Study Type : In Vitro Study

Additional Links

Substances : Anandamide

Diseases : Burkitt Lymphoma, Lymphoma, Lymphoma: Non-Hodgkin

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Cannabinoid Receptors

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View the Evidence: 55 Abstracts with Cannabinoid Receptors Research

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Anandamide is a potent and selective inhibitor of the proliferation of breast cancer cells.Jul 06, 1998

Cannabidiol causes vasorelaxation of the human mesenteric artery.Aug 31, 2015

Elevated CB2 receptor expression was identified in glioblastoma cells.Jun 29, 2009

Endocannabinoid and ceramide levels are altered in patients with colorectal cancer.Jun 30, 2015

A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice.May 07, 2017

A synthetic cannabinoid inhibited CXCL12-induced migration and invasive properties of breast cancer cells.Dec 31, 2010

Activation of cannabinoid receptors could be a new therapeutic approach for the treatment of skin tumors.Dec 31, 2002

Beta-caryophyllene constitutes an alluring therapeutic molecule towards the treatment of multiple sclerosis.Mar 31, 2017

Beta-caryophyllene could be useful for prevention and treatment of antiretroviral-induced neuropathic pain.Dec 26, 2019

Black raspberry extracts may benefit osteoporotic patients with prostatic disease by simultaneously altering the activation of osteoblasts and osteoclasts.May 31, 2015

Cannabidiol enhanced the ability of THC to inhibit cell proliferation, induce cell cycle arrest and apoptosis.Dec 31, 2009

Cannabinoids inhibit the growth of melanoma cells but not of normal melanocytes.Nov 30, 2006

Cannabinoids were effective in reducing the tumor load, prolonging the mean survival time as well as curing a significant proportion of mice in this study.Jul 14, 2002

Chronic exercise modulates the cellular immunity and its cannabinoid receptors expression.Dec 31, 2018

Electroacupuncture inhibits CB1 upregulation induced by ethanol withdrawal in mice.Jun 30, 2012

Electroacupuncture potentiates cannabinoid receptor-mediated descending inhibitory control in a mouse model of knee osteoarthritis.Dec 31, 2017

Electroacupuncture pretreatment enhances STAT3 activation via CB1R to protect against cerebral ischemia.Sep 04, 2013

Electroacupuncture reduces visceral pain Via cannabinoid CB2 receptors in a mouse model of inflammatory bowel disease.Dec 31, 2021

Extravirgin olive oil up-regulates CB₁ tumor suppressor gene in human colon cancer cells.Feb 28, 2015

Paeoniflorin exerts a neuroprotective effect in model of dementia.Dec 31, 2017

Palmitoylethanolamide attenuates PTZ-induced seizures through CB1 and CB2 receptors.Oct 31, 2015

Palmitoylethanolamide improves murine experimental colitis.Dec 31, 2014

Synthetic cannabinoids inhibited growth, migration and invasion of NSCLC cells in in vitro as well as in vivo in a mouse model.Dec 31, 2010

THC may provide a protective effect against oxidative damage induced by diabetes.Sep 30, 2014

The discovery of IL-12-induced CB2 overexpression in thyroid cancer cells may offer a new target for anaplastic thyroid cancer treatmentJan 31, 2008

The in vivo assessment of the role of CB receptors in inflammation and cancer might be instrumental in broadening the understanding about bladder cancer biology.Sep 30, 2015

These results confirm the value of exogenous cannabinoids for the treatment of melanomas. Sep 30, 2015

Zerumbone ameliorates neuropathic pain symptoms.Jun 23, 2021

β-Caryophyllene, a natural bicyclic sesquiterpene attenuates doxorubicin-induced cardiotoxicity.Mar 01, 2019

Δ9-tetrahydrocannabinol prevents mortality from acute respiratory distress syndrome.Aug 27, 2020

An analogue of anandamide Met-F-AEA could have significance in providing a basis for the management of thyroid carcinomas.Mar 31, 2010

Beta-caryophyllene administration could be a novel treatment to reduce hyper-inflammation in human sepsis.Dec 31, 2017

Cannabinoid receptor ligands induce decreased viability, growth suppression and cell death by apoptosis in MCL cells.Dec 18, 2005

Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.Nov 22, 1999

Cannabinoids - via direct or indirect activation of CB(1) and/or CB(2) receptors exert protective effects in well-established models of intestinal inflammation and colon cancer.Jul 31, 2009

Cannabinoids are promising candidates for gastrointestinal and urinary diseases.Dec 31, 2014

Cannabinoids exert anti-inflammatory, anti-proliferative, anti-invasive, anti-metastatic and pro-apoptotic effects in different cancer types.May 31, 2015

Cannabinoids have the potential to regulate the activation and balance of human Th1/Th2 cells by a CB2 receptor-dependent pathway.Nov 30, 2002

Cannabinoids might be a suitable treatment for rheumatoid arthritis.Apr 30, 2019

Cannabinoids modulate neuronal activity and cancer by CB1 and CB2 receptor-independent mechanisms.Dec 31, 2016

Cannabinoids possess attributes that have impact in both cancer pain and prostate cancer pathophysiology.Dec 31, 2011

Cannabinoids prevent proliferation and cause apoptosis via a combination of cannabinoid receptor-independent, cellular and molecular mechanisms.Dec 31, 2012

CB1 receptor immunoreactivity was significantly lower while CB2 receptor immunoreactivity was significantly greater in the membranes of glioblastoma multiforme and astrocytoma.Apr 30, 2010

CB2 receptor activation signals apoptosis via a ceramide-dependent stimulation of the mitochondrial intrinsic pathway.Jun 30, 2006

Electroacupuncture increases the CB2 receptor expression on keratinocytes and infiltrating inflammatory cells in inflammatory skin tissues.Nov 30, 2010

In the current study we demonstrated that cannabidiol can induce apoptosis in murine as well as human leukemia cells.Aug 31, 2006

The endocannabinoid system controls the growth and metastasis of malignant cells.Apr 30, 2003

The experimental evidence reviewed in this article argues in favor of the therapeutic potential of these compounds in immune disorders and cancer.Jan 31, 2002

The present study reviews current insights into the role of cannabinoids and their receptors on viral infections.Dec 31, 2015

These results show an association between elevated CB2 expression in HER2+ breast tumors and poor patient prognosis.May 31, 2015

This review critically discusses the pharmacology of CB receptor activation as a novel therapeutic anticancer strategyJun 30, 2009

This review discusses how the endocannabinoid system can help treat diseases of the skin.Jul 31, 2009

This review summarises the demonstrated antitumour actions of cannabinoids and indicating possible avenues for cannabinoids as antitumour agents.Nov 30, 2003

Using cannabinoid receptor ligands will have efficiency in reducing tumor burden in malignant lymphoma overexpressing CB1 and CB2.Aug 31, 2008

ω-3 endocannabinoid epoxides have anti-inflammatory effects. Jul 06, 2017

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Cannabinoid Receptors

View the Evidence:
55 Abstracts with Cannabinoid Receptors Research