Chemothapeutic Synergy: Paclitaxel

Name	AC	CK
Breast Cancer	40	61
Lung Cancer	13	18
Cancers: Drug Resistant	13	16
Ovarian Cancer	12	13
Breast Cancer: Triple Negative	9	11
Carcinoma: Non-Small-Cell Lung	8	10
Cervical Cancer	8	9
Cancers: All	7	8
Cancers: Multi-Drug Resistant	4	7
Prostate Cancer	5	6
Esophageal Cancer	3	5
Gastric Cancer	4	5
Chemotherapy-Induced Toxicity: Paclitaxel	2	4
Glioma	2	4
Colon Cancer	3	3
Kidney Cancer	3	3
Non-Small-Cell Lung Carcinoma	3	3
Pancreatic Cancer	3	3
Skin Cancer	2	3
Bladder Cancer	1	2
Bone Cancer	2	2
Chemotherapy-Induced Toxicity: Tamoxifen	1	2
Ehrlich carcinoma	1	2
Head and Neck Cancer	1	2
Liver Cancer	2	2
Thyroid Cancer	1	2
Acute Myeloid Leukemia	1	1
Breast Cancer Stem Cells	1	1
Cancer Metastasis	1	1
Chemotherapy-Induced Toxicity: Cisplatin	1	1
Choriocarcinoma	1	1
Colorectal Cancer	1	1
Endometrial Cancer	1	1
Glioblastoma	1	1
Intestinal Cancer	1	1
Oral Cancer	1	1

Name	AC	CK
Curcumin	12	23
Ginsenosides	7	11
Nobiletin	3	5
Beta-Elemene	4	4
Honokiol	4	4
Ashwagandha	2	3
Astragaloside	1	3
Cannabidiol	2	3
Flavonoids	2	3
Ligustrazine	2	3
Luteolin	2	3
Modified Arabinoxylan Rice Bran (MGN-3)	2	3
Silibinin	2	3
Thymoquinone	3	3
Ursolic Acid	2	3
Vitamin D	2	3
Alpha-Lipoic Acid	2	2
Andrographis	2	2
Asparagus	1	2
Bamboo	1	2
Berbamine	1	2
Betulinic acid	2	2
Butterfly Pea	1	2
Caffeic Acid	1	2
Cannabinoids	1	2
Cannabinoids: Synthetic	1	2
Carvacrol	1	2
Crocin	2	2
Diallyl sulfide	1	2
Echinacea	1	2
Fisetin	2	2
Ginseng (Korean)	1	2
Lotus	1	2
Mulberry	1	2
Naringenin	1	2
Paeonol	1	2
Piperlongumine	2	2
Quercetin	2	2
Resveratrol	2	2
Rosemaric Acid	1	2
Shikonin	2	2
Tanshinone IIA	2	2
Tomato	1	2
Vitamin C	1	2
Wogonin	1	2
Andrographolide	1	1
Artesunate	1	1
Berberine	1	1
Bitter Melon	1	1
Caffeic acid phenethyl ester	1	1
Cardamonin	1	1
Catechols	1	1
Citrus naringin	1	1
Cucurbitacin B	1	1
Diosmetin	1	1
Elecampane	1	1
Ellagic Acid	1	1
Fermented Foods and Beverages	1	1
Folic Acid	1	1
Formononetin	1	1
Gallic Acid	1	1
Geraniol	1	1
Ginger	1	1
Gingerol	1	1
Hydroxytyrosol	1	1
Modified Citrus Pectin	1	1
Mululuza	1	1
Nettle	1	1
Oleuropein	1	1
Organosulfur Compounds	1	1
Panax Ginseng	1	1
Psychedelics:All	1	1
Sesamol	1	1
Spirulina	1	1
Sulforaphane	1	1
Tetrahydrocurcumin	1	1
Viruses: Beneficial	1	1
Zerumbone	1	1

Name	AC	CK	Focus
Heat Therapy	1	1
Ultrasound therapy	1	1

Name	AC	CK
Apoptotic	53	72
Chemosensitizer	52	68
Antiproliferative	34	44
Chemotherapeutic	23	38
Antineoplastic Agents	11	13
Cell cycle arrest	10	13
Anti-metastatic	8	10
NF-kappaB Inhibitor	7	9
Bcl-2 protein down-regulation	5	7
Tumor Suppressor Protein p53 Upregulation	5	7
Chemoprotective Agents	3	5
Anti-Inflammatory Agents	3	4
Angiogenesis Inhibitors	2	3
Chemopreventive	2	3
Multidrug Resistance Gene Modulators	3	3
Vascular Endothelial Growth Factor Inhibitors	2	3
Antinoceceptive	1	2
Cannabinoid Receptor Antagonist/Inverse Agonist	1	2
Cyclooxygenase 2 Inhibitors	2	2
Immunomodulatory	2	2
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	2
P21 Activation	2	2
PI3K-AKT inhibitor	1	2
Radiosensitizer	2	2
Antioxidants	1	1
Autophagy Inhibitors	1	1
Bax/Bcl2 ratio: Increase	1	1
Caspase-3 Activation	1	1
Heat Shock Protein Down-Regulation	1	1
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	1
MicroRNA modulator	1	1
Paraptosis	1	1
STAT3 Inhibitor	1	1
Survivin Down-Regulation	1	1
Tumor Necrosis Factor (TNF) Alpha Inhibitor	1	1

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Pubmed Data : Biomed Pharmacother. 2017 Feb 20 ;89:227-232. Epub 2017 Feb 20. PMID: 28231544

Article Published Date : Feb 19, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Bcl-2 protein down-regulation, Chemosensitizer, NF-kappaB Inhibitor

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

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Inhibiting tumour metastasis by DQA modified paclitaxel plus ligustrazine micelles in treatment of non-small-cell lung cancer.Nov 30, 2019

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Pubmed Data : Turk Arch Otorhinolaryngol. 2020 Dec ;58(4):241-248. Epub 2020 Dec 1. PMID: 33554199

Article Published Date : Nov 30, 2020

Study Type : Animal Study

Additional Links

Substances : Carvacrol

Diseases : Chemotherapy-Induced Toxicity: Paclitaxel

Pharmacological Actions : Chemoprotective Agents

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

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Rosmarinic acid suppresses inflammation, angiogenesis, and improves paclitaxel induced apoptosis in a breast cancer model.Nov 30, 2021

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Wogonin combined with low-dose paclitaxel obtained the same efficacy as with high dose Paclitaxel reducing tumor burden by 61%.Sep 30, 2013

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Cardamonin inhibits the expression of P-glycoprotein and enhances the anti-proliferation of paclitaxel on SKOV3-Taxol cells.Dec 31, 2021

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Pubmed Data : J Nat Med. 2022 Jan ;76(1):220-233. Epub 2021 Nov 9. PMID: 34751899

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

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Substances : Cardamonin

Diseases : Ovarian Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

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Chemovirotherapy of pancreatic adenocarcinoma by combining oncolytic vaccinia virus GLV-1h68 with nab-paclitaxel plus gemcitabine.Sep 14, 2017

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Pubmed Data : Tumour Biol. 2017 Apr ;39(4):1010428317698353. PMID: 28443468

Article Published Date : Mar 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Chemosensitizer

Additional Keywords : Carcinoma: Non-Small-Cell Lung, Chemosensitizer, Chemothapeutic Synergy: Paclitaxel, CURCUMIN

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Curcumin sensitized breast cancer cells to chemotherapeutic drugs by reducing the BCSC population mainly through a reduction in the expression of ABCG2.Dec 31, 2014

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Formononetin ameliorates the drug resistance of Taxol resistant triple negative breast cancer by inhibiting autophagy.Dec 31, 2020

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Pubmed Data : Anticancer Res. 2014 Jan ;34(1):81-7. PMID: 24403447

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Modified Arabinoxylan Rice Bran (MGN-3)

Diseases : Breast Cancer, Cancer Metastasis

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

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Modified citrus pectin targets galectin-3-induced STAT3 activation and synergize paclitaxel cytotoxic effect on ovarian cancer spheroids.Jul 31, 2019

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Sulforaphane enhances the anticancer activity of taxanes against triple negative breast cancer by killing cancer stem cells.Feb 26, 2017

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Pubmed Data : Cancer Lett. 2017 Feb 27. Epub 2017 Feb 27. PMID: 28254410

Article Published Date : Feb 26, 2017

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Chemosensitizer, Chemotherapeutic

Additional Keywords : Cancer Stem Cells, Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Docetaxel

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Synergistic anticancer effects of andrographolide and paclitaxel against A549 NSCLC cells.Oct 31, 2016

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Pubmed Data : J Oncol. 2022 ;2022:7961537. Epub 2022 Sep 16. PMID: 36157225

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Tetrahydrocurcumin

Diseases : Breast Cancer

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

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Tetramethylpyrazine enhances the antitumor effect of paclitaxel by inhibiting angiogenesis and inducing apoptosis.Dec 31, 2018

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View the Evidence: 119 Abstracts with Chemothapeutic Synergy: Paclitaxel Research

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Effect of turmeric supplementation on the pharmacokinetics of paclitaxel in breast cancer patients.Feb 17, 2022

Astragaloside IV enhances the sensitivity of breast cancer stem cells to paclitaxel by inhibiting stemness.Dec 30, 2023

Paclitaxel-loaded ginsenoside Rg3 liposomes for drug-resistant cancer therapy.Sep 23, 2022

A multiple-targets alkaloid nuciferine overcomes paclitaxel-induced drug resistance in vitro and in vivo.Sep 09, 2020

Amelioration of combination of paclitaxel and di allyl sulfide on the alterations of Bcl2, P53 and apoptosis changes against 7,12 Di methyl benz (A) anthracene induced skin cancer.Mar 31, 2021

Bamboo concentrate enhances the bioavailability of the chemotherapy agent paclitaxel. Nov 01, 2010

Berbamine has synergistic antitumor effects with paclitaxel in glioma cells.Dec 31, 2016

Caffeic acid inhibited non-small-cell lung cancer cell growth by inducing apoptosis.Dec 31, 2017

Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma.Jan 25, 2020

Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells.Jan 31, 2013

Combinations of nobiletin with paclitaxel and carboplatin significantly suppressed the growth of subcutaneous A549 tumors xenografts in nude mice.Mar 31, 2014

Curcumin and vitamin D3 enhanced the tumor response to paclitaxel.Oct 15, 2019

Curcumin is a potent chemosensitizer to improve the therapeutic index of paclitaxel.Jul 13, 2011

Echinacea angustifolia extract is a potential candidate for breast cancer treatment.Sep 21, 2020

Exogenous vitamin C boosts the antitumor efficacy of paclitaxel containing reduction-sensitive shell-sheddable micelles in vivo.Feb 01, 2017

Flavopiridol and paclitaxel exerted synergistic cytotoxic activities against SKOV3 cells in vitro and significantly suppress the tumor growth of mice bearing SKOV3 cells.Dec 31, 2014

Ginsenoside Rg3 promotes cytotoxicity and apoptosis of Paclitaxel by inhibiting NF-κB signalling.Feb 19, 2017

Inhibiting tumour metastasis by DQA modified paclitaxel plus ligustrazine micelles in treatment of non-small-cell lung cancer.Nov 30, 2019

Korean red ginseng extract enhances paclitaxel distribution to mammary tumors.May 16, 2016

Luteolin combined with low-dose paclitaxel synergistically inhibits epithelial-mesenchymal transition and induces cell apoptosis on esophageal carcinoma.Sep 06, 2021

MGN-3 supplementation enhances tumor cell demise in the presence of a low dose of paclitaxel.Jun 30, 2016

Molecular mechanisms of Asparagus racemosus willd. and Withania somnifera (L.) Dunal as chemotherapeutic adjuvants for breast cancer treatment.Apr 27, 2024

Mulberry water extract enhanced the cytotoxicity of paclitaxel and induced severe G2/M arrest, mitotic catastrophe and subsequent apoptosis.Dec 31, 2015

Naringenin relieves paclitaxel-induced pain by suppressing calcitonin gene-related peptide signalling.May 06, 2024

Nobiletin reversed paclitaxel resistance in multi-drug resistance tumors.Nov 25, 2019

Paeonol reversed paclitaxel resistance in MCF-7/PTX cells by downregulating the activity of the SET/PP2A/Akt pathway.Jun 30, 2015

Protective effect of carvacrol against paclitaxel-induced ototoxicity. Nov 30, 2020

Rosmarinic acid suppresses inflammation, angiogenesis, and improves paclitaxel induced apoptosis in a breast cancer model.Nov 30, 2021

Silybin and paclitaxel in dextran-based nanoparticles are an effective treatment through chemotherapy sensitization and microenvironment modulation.Feb 06, 2020

The discovery of IL-12-induced CB2 overexpression in thyroid cancer cells may offer a new target for anaplastic thyroid cancer treatmentJan 31, 2008

The synergistic anti cancer effects of paclitaxel and α-tomatine may be beneficial for refractory prostate cancer treatment.Nov 14, 2013

These results showed that 20(s)-ginsenoside Rg3 enhanced the oral bioavailability of paclitaxel.Oct 31, 2012

Ursolic acid accelerates paclitaxel-induced cell death in esophageal cancer cells.Oct 24, 2021

Wogonin combined with low-dose paclitaxel obtained the same efficacy as with high dose Paclitaxel reducing tumor burden by 61%.Sep 30, 2013

Design and development of spirulina polysaccharide-loaded nanoemulsions with improved the antitumor effects of paclitaxel.May 25, 2020

Enhanced lysosomal function is critical for paclitaxel resistance in cancer cells: reversed by artesunate.Jul 22, 2020

Piperlongumine increases the apoptotic effect of doxorubicin and paclitaxel in a cervical cancer cell line.Feb 29, 2020

Piperlongumine induces ROS mediated cell death and synergizes paclitaxel in human intestinal cancer cells.Jul 31, 2020

Synergistic combinations of paclitaxel and withaferin A against human non-small cell lung cancer cells.Apr 20, 2020

Synergistic killing effect of paclitaxel and honokiol in non-small cell lung cancer cells through paraptosis induction.Sep 15, 2020

3,3'-diindolylmethane enhances paclitaxel sensitivity in breast cancer. Dec 31, 2020

6-Gingerol with 5-flourouracil and paclitaxel resulted in 83.2% and 52% inhibition of cervical cancer cells. Feb 26, 2017

A combination of curcumin and paclitaxel exhibited synergistic anti-proliferative and pro-apoptosis effects on Hep3B cells.Jun 24, 2015

Administration with hyperoside sensitizes breast cancer cells to paclitaxel by blocking the TLR4 signaling.Jan 09, 2020

Andrographolide demonstrated antiproliferative and apoptotic properties.Dec 31, 2019

Anti-cancer effects of alpha lipoic acid, cisplatin and paclitaxel combination in the OVCAR-3 ovarian adenocarcinoma cell line.Apr 04, 2024

Anticancer efficacy of 6-gingerol with paclitaxel against wild type of human breast adenocarcinoma.Apr 21, 2022

Beta-elemene had synergistic effect with paclitaxel.Jun 30, 2013

Betulinic acid in the treatment of breast cancer: Application and mechanism progress.Aug 31, 2023

Bitter melon extract treatment has a significant effect on uptake of the 99mTc-PAC on MCF-7 cells.Apr 23, 2020

Caffeic acid phenethyl ester synergistically enhances paclitaxel activity in ovarian cancer cells.Jul 31, 2023

Cardamonin inhibits the expression of P-glycoprotein and enhances the anti-proliferation of paclitaxel on SKOV3-Taxol cells.Dec 31, 2021

Chemovirotherapy of pancreatic adenocarcinoma by combining oncolytic vaccinia virus GLV-1h68 with nab-paclitaxel plus gemcitabine.Sep 14, 2017

Co-delivery of paclitaxel and honokiol suppressed multidrug resistance and metastasis of breast cancer.Aug 27, 2017

Co-treatment with low dose berberine could significantly attenuate the anticancer activity of chemotherapeutic agents.Dec 31, 2014

Combination of curcumin and paclitaxel liposomes exhibits enhanced cytotoxicity towards A549/A549-T cells.Jul 31, 2020

Combination of shikonin with paclitaxel overcomes multidrug resistance in human ovarian carcinoma cells.Dec 31, 2018

Combined treatment of β-elemene-paclitaxel is more effective at inhibiting bone neoplasm growth than β-elemene or paclitaxel single treatment GPR124.Jul 31, 2018

Combined ultrasonic treatment and chemotherapy with paclitaxel showed a significantly increased killing of MCF7 cells compared to both monotherapies.Dec 31, 2014

Crocin and paclitaxel and crocin and gamma radiation had synergistic effect on MCF-7 cell line to get more significant apoptosis.Dec 31, 2014

Crocin enhances the sensitivity to paclitaxel in human breast cancer cells by reducing BIRC5 expression.Jan 31, 2024

Cucurbitacin B, showed potential in vitro synergistic antiproliferative effects combined with paclitaxel in A549 cells.Jun 09, 2017

Curcumin by itself was as good as carboplatin or paclitaxel in inducing apoptosis in the primary ovarian cancer cells.Mar 31, 2016

Curcumin has the ability to improve the paclitaxel induced apoptosis of HPV positive human cervical cancer cell lines via the NF-κB-p53-caspase-3 pathway.Mar 31, 2015

Curcumin might be a potential adjuvant for non-small-cell lung cancer patients during Paclitaxel treatment.Mar 31, 2017

Curcumin sensitized breast cancer cells to chemotherapeutic drugs by reducing the BCSC population mainly through a reduction in the expression of ABCG2.Dec 31, 2014

Cytotoxicity of Tanshinone IIA combined with Taxol on drug-resist breast cancer cells MCF-7 through inhibition of Tau.Mar 31, 2018

Diosmetin induces apoptosis and enhances the chemotherapeutic efficacy of paclitaxel in non-small cell lung cancer cells.May 31, 2019

Effect of Gallic acid in potentiating chemotherapeutic effect of paclitaxel in HeLa cervical cancer cells.Dec 31, 2018

Effect of ginseng rare ginsenoside components combined with paclitaxel on A549 lung cancer.Mar 31, 2018

Fermented red ginseng extract may be more effective for decreasing cancer cell survival by inducing apoptotic cell death.Mar 31, 2015

Folic acid significantly enhanced the efficacy of curcumin in down-regulating various survival signals induced by paclitaxel in cervical cancer.Dec 07, 2017

Chemothapeutic Synergy: Paclitaxel

View the Evidence:
119 Abstracts with Chemothapeutic Synergy: Paclitaxel Research