Cytokine Modulation

Name	AC	CK	Focus
Oseltamivir (trade name Tamiflu)	1	10
Zanamivir	1	10

Name	AC	CK
Coronavirus Infection	14	23
Influenza	2	11
Influenza A	2	11
H1N1 Infection	1	10
H3N2 Infection	1	10
Influenza: Human	1	10
Vitamin D Deficiency	1	10
Virally-Induced Cytokine Storm	4	5
Inflammation	2	4
Acute Respiratory Distress Syndrome	2	3
AIDS	1	2
Breast Cancer	1	2
Breast Cancer: Metastatic	1	2
Breast Cancer: Triple Negative	1	2
High Fat Diet	1	2
Melanoma	1	2
Melanoma: Metastasis	1	2
Multiple Sclerosis	1	2
Obesity	1	2
Dengue Fever	1	1
Ebola	1	1
Vesicular Stomatitis Virus	1	1

Name	AC	CK
Vitamin D	4	13
Apricot Kernel	1	10
Cinnamon	1	10
Elderberry	1	10
Ephedra sinica (Ma Huang)	1	10
Probiotics	2	3
Vitamin C	2	3
Andrographolide	2	2
Delta-tetrahydrocannabinol (THC)	1	2
Echinacea	2	2
Lactobacillus casei	1	2
Lactoferrin	2	2
Resveratrol	1	2
Vitamin E	1	2
Beta-glucan	1	1
Burdock	1	1
Cat's Claw	1	1
Chinese Skullcap	1	1
Curcumin	1	1
Feverfew	1	1
Ginger	1	1
Ginseng	1	1
Honeysuckle	1	1
Magnolia	1	1
NAC (N-acetyl-L-cysteine)	1	1
Parthenolide	1	1
Polyphenols	1	1
Saffron	1	1
Salvia miltiorrhiza	1	1
Selenium	1	1
Shitake Mushroom	1	1

Name	AC	CK	Focus
Laser Treatment: Low-Level	1	1

Name	AC	CK
Antiviral Agents	6	24
Anti-Inflammatory Agents	11	22
Tumor Necrosis Factor (TNF) Alpha Enhancer	2	11
Enzyme Inhibitors	1	10
Immunomodulatory	9	9
Interleukin-6 Downregulation	5	7
Tumor Necrosis Factor (TNF) Alpha Inhibitor	6	7
Interleukin-8 downregulation	3	3
Anti-metastatic	1	2
Antioxidants	1	2
Antiproliferative	1	2
Apoptotic	1	2
Interleukin-17 downregulation	1	2
Interleukin-2 Downregulation	2	2
MicroRNA modulator	1	2
Anti-Asthmatic Agents	1	1
Gastrointestinal Agents	1	1
Interleukin-22 Downregulation	1	1
Neuroprotective Agents	1	1
Prophylactic Agents	1	1

[+]

Evidence for possible association of vitamin D status with cytokine storm and unregulated inflammation in COVID-19 patients.Sep 01, 2020

Click here to read the entire abstract

Pubmed Data : Aging Clin Exp Res. 2020 Sep 2. Epub 2020 Sep 2. PMID: 32876941

Article Published Date : Sep 01, 2020

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Coronavirus Infection, Vitamin D Deficiency

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Cytokine Modulation, Cytokine Storm

[+]

Elderberry stimulates cytokine production in the healthy immune system to fight off viral infection.Apr 01, 2001

Click here to read the entire abstract

Pubmed Data : Eur Cytokine Netw. 2001 Apr-Jun;12(2):290-6.PMID:11399518

Article Published Date : Apr 01, 2001

Study Type : Human Study

Additional Links

Substances : Elderberry

Diseases : Influenza: Human

Pharmacological Actions : Antiviral Agents, Tumor Necrosis Factor (TNF) Alpha Enhancer

Additional Keywords : Cytokine Modulation

[+]

The administration of oral maoto granules to healthy adults with seasonal influenza was well tolerated and associated with equivalent clinical and virological efficacy to oseltamivir or zanamivir.Jul 31, 2012

Click here to read the entire abstract

Pubmed Data : J Infect Chemother. 2012 Aug ;18(4):534-43. Epub 2012 Feb 16. PMID: 22350323

Article Published Date : Jul 31, 2012

Study Type : Human Study

Additional Links

Substances : Apricot Kernel, Cinnamon, Ephedra sinica (Ma Huang)

Diseases : H1N1 Infection, H3N2 Infection , Influenza, Influenza A

Pharmacological Actions : Antiviral Agents, Enzyme Inhibitors

Additional Keywords : Cytokine Modulation, Maoto Granules, Natural Substances Versus Drugs

Problem Substances : Oseltamivir (trade name Tamiflu), Zanamivir

[+]

Ascorbate supplementation hinders metastasis, tumor growth and inflammatory cytokine secretion as well as enhanced encapsulation of tumors elicited by melanoma and breast cancer.Dec 31, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Oncol. 2013 Jan ;42(1):55-64. Epub 2012 Nov 21. PMID: 23175106

Article Published Date : Dec 31, 2012

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Breast Cancer, Breast Cancer: Metastatic, Breast Cancer: Triple Negative , Inflammation, Melanoma, Melanoma: Metastasis

Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Antioxidants, Antiproliferative , Apoptotic

Additional Keywords : Cytokine Modulation, Significant Treatment Outcome, Supplementation

[+]

Resveratrol relieves symptoms in experimental autoimmune encephalomyelitis, an animal model of Multiple Sclerosis, by modulating cytokines and macrophages. Jan 01, 2009

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2009 Jan;9(1):134-43. Epub 2008 Nov 18. PMID: 19022403

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Multiple Sclerosis

Pharmacological Actions : Interleukin-6 Downregulation

Additional Keywords : Cytokine Modulation

[+]

The administration of probiotic L. casei exerted an anti-inflammatory response in mice fed an high fat diet.Jun 30, 2015

Click here to read the entire abstract

Pubmed Data : Nutrition. 2015 Jul-Aug;31(7-8):1000-7. Epub 2015 Feb 24. PMID: 26059375

Article Published Date : Jun 30, 2015

Study Type : Animal Study

Additional Links

Substances : Lactobacillus casei, Probiotics

Diseases : High Fat Diet, Inflammation, Obesity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Cytokine Modulation

[+]

Vitamin E supplementation modulates immune function and cytokine production during a mouse experimental model of virally-induced AIDS. Apr 01, 1995

Click here to read the entire abstract

Pubmed Data : Immunopharmacology. 1995 Apr;29(3):225-33. PMID: 7622353

Article Published Date : Apr 01, 1995

Study Type : Animal Study

Additional Links

Substances : Vitamin E

Diseases : AIDS, Virally-Induced Cytokine Storm

Additional Keywords : Cytokine Modulation

[+]

Δ9-tetrahydrocannabinol prevents mortality from acute respiratory distress syndrome.Aug 27, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2020 Aug 28 ;21(17). Epub 2020 Aug 28. PMID: 32872332

Article Published Date : Aug 27, 2020

Study Type : Animal Study

Additional Links

Substances : Delta-tetrahydrocannabinol (THC)

Diseases : Acute Respiratory Distress Syndrome

Pharmacological Actions : MicroRNA modulator

Additional Keywords : Cannabinoid Receptors, Cytokine Modulation, Cytokine Storm

[+]

Cytokine storm in COVID-19 and parthenolide: Preclinical evidence.May 29, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Phytother Res. 2020 May 30. Epub 2020 May 30. PMID: 32472655

Article Published Date : May 29, 2020

Study Type : Commentary

Additional Links

Substances : Feverfew, Parthenolide

Diseases : Coronavirus Infection

Pharmacological Actions : Immunomodulatory, Interleukin-2 Downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Cytokine Modulation, Cytokine Storm

[+]

The importance of vitamin d metabolism as a potential prophylactic, immunoregulatory and neuroprotective treatment for COVID-19.Jan 25, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Transl Med. 2020 08 26 ;18(1):322. Epub 2020 Aug 26. PMID: 32847594

Article Published Date : Jan 25, 2020

Study Type : Review

Additional Links

Substances : Vitamin D

Diseases : Coronavirus Infection

Pharmacological Actions : Immunomodulatory, Neuroprotective Agents, Prophylactic Agents

Additional Keywords : Cytokine Modulation, Cytokine Storm

[+]

A systematic review on the effects of Echinacea supplementation on cytokine levels.Jul 28, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Metabol Open. 2021 Jul 29:100115. Epub 2021 Jul 29. PMID: 34341776

Article Published Date : Jul 28, 2021

Study Type : Review

Additional Links

Substances : Echinacea

Diseases : Coronavirus Infection

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Cytokine Modulation, Cytokine Storm

[+]

Andrographolide could bind with TNF and NFkB1 proteins, block TNF-induced cytokine storm in COVID-19 patients.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Immunol. 2021;12:648250. Epub 2021 Jun 24. PMID: 34248936

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Andrographolide

Diseases : Coronavirus Infection

Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Cytokine Modulation, Cytokine Storm

[+]

Andrographolide may be effective in lowering cytokine storm and treating severe symptoms.Jul 16, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2022 Jul 17 ;27(14). Epub 2022 Jul 17. PMID: 35889428

Article Published Date : Jul 16, 2022

Study Type : In Vitro Study

Additional Links

Substances : Andrographolide

Diseases : Coronavirus Infection

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Cytokine Modulation, Cytokine Storm

[+]

Curcumin suppression of cytokine release and cytokine storm. A potential therapy for patients with Ebola and other severe viral infections.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : In Vivo. 2015 Jan-Feb;29(1):1-4. PMID: 25600522

Article Published Date : Dec 31, 2014

Study Type : Review

Additional Links

Substances : Curcumin

Diseases : Ebola

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Cytokine Modulation, Cytokine Storm

[+]

Echinacea root contains cytokine-modulating capability that may be therapeutic in combating influenza A infections. Jul 01, 2009

Click here to read the entire abstract

Pubmed Data : NMR Biomed. 2009 Jul;22(6):585-92. PMID: 17021999

Article Published Date : Jul 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Echinacea

Diseases : Influenza, Influenza A, Virally-Induced Cytokine Storm

Additional Keywords : Cytokine Modulation

[+]

L. edodes may have future potential by way of influencing immunotherapies for addressing COVID-19 that rely on reducing cytokine storm.Aug 24, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Total Environ. 2020 Aug 25 ;732:139330. Epub 2020 May 11. PMID: 32413619

Article Published Date : Aug 24, 2020

Study Type : In Vitro Study

Additional Links

Substances : Beta-glucan, Shitake Mushroom

Diseases : Coronavirus Infection

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Interleukin-22 Downregulation, Interleukin-2 Downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Cytokine Modulation, Cytokine Storm

[+]

Low-level laser therapy combined with conventional medical therapy has the potential to prevent the progression of COVID-19.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Can J Respir Ther. 2020 ;56:25-31. Epub 2020 Jul 23. PMID: 32844112

Article Published Date : Dec 31, 2019

Study Type : Review

Additional Links

Diseases : Acute Respiratory Distress Syndrome, Coronavirus Infection

Therapeutic Actions : Photobiomodulation

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Cytokine Modulation, Cytokine Storm

[+]

Mini-Review on the Roles of Vitamin C, Vitamin D, and Selenium in the Immune System against COVID-19.Nov 15, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2020 Nov 16 ;25(22). Epub 2020 Nov 16. PMID: 33207753

Article Published Date : Nov 15, 2020

Study Type : Review

Additional Links

Substances : Selenium, Vitamin C, Vitamin D

Diseases : Coronavirus Infection

Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents, Immunomodulatory

Additional Keywords : Cytokine Modulation

[+]

Natural immunomodulators treat the cytokine storm in SARS-CoV-2.Dec 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Adv Pharm Bull. 2023 Jan ;13(1):79-87. Epub 2021 Oct 2. PMID: 36721816

Article Published Date : Dec 31, 2022

Study Type : Review

Additional Links

Substances : Lactoferrin, Polyphenols

Diseases : Coronavirus Infection

Pharmacological Actions : Antiviral Agents, Immunomodulatory

Additional Keywords : Cytokine Modulation, Cytokine Storm, Essential Oils

[+]

Probiotics supplementation could reduce the severity of COVID-19 morbidity and mortality.Mar 18, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Arch Med Res. 2021 Mar 19. Epub 2021 Mar 19. PMID: 33785208

Article Published Date : Mar 18, 2021

Study Type : Review

Additional Links

Substances : Probiotics

Diseases : Coronavirus Infection

Pharmacological Actions : Gastrointestinal Agents, Immunomodulatory

Additional Keywords : Cytokine Modulation, Cytokine Storm, Risk Reduction

[+]

Saffron represents a promising substance for toning down cytokine storm during COVID-19.Aug 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Metabol Open. 2021 Sep ;11:100111. Epub 2021 Jul 21. PMID: 34312610

Article Published Date : Aug 31, 2021

Study Type : Review

Additional Links

Substances : Saffron

Diseases : Coronavirus Infection

Pharmacological Actions : Anti-Asthmatic Agents, Immunomodulatory

Additional Keywords : Cytokine Modulation, Cytokine Storm

[+]

Scutellaria baicalensis (Chinese skullcap) stimulates resistance to viral infection in human leukocytes through the beneficial modulation of cytokines. Sep 01, 2008

Click here to read the entire abstract

Pubmed Data : J Interferon Cytokine Res. 2008 Sep;28(9):571-81. PMID: 18771341

Article Published Date : Sep 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Chinese Skullcap

Diseases : Vesicular Stomatitis Virus, Virally-Induced Cytokine Storm

Pharmacological Actions : Antiviral Agents, Tumor Necrosis Factor (TNF) Alpha Enhancer

Additional Keywords : Cytokine Modulation

[+]

The potential for Lactoferrin to reduce SARS-CoV-2 induced cytokine storm.Mar 11, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int Immunopharmacol. 2021 Mar 12 ;95:107571. Epub 2021 Mar 12. PMID: 33765614

Article Published Date : Mar 11, 2021

Study Type : In Vitro Study

Additional Links

Substances : Lactoferrin

Diseases : Coronavirus Infection

Pharmacological Actions : Immunomodulatory

Additional Keywords : Cytokine Modulation, Cytokine Storm

[+]

This study intends to provide reference for clinical use of traditional Chinese medicine to resist new coronavirus.Feb 29, 2020

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2020 Mar ;45(6):1225-1231. PMID: 32281329

Article Published Date : Feb 29, 2020

Study Type : In Vitro Study

Additional Links

Substances : Burdock, Ginger, Ginseng, Honeysuckle, Magnolia, Salvia miltiorrhiza

Diseases : Coronavirus Infection

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Cytokine Modulation, Cytokine Storm

[+]

Uncaria tomentosa (cat's claw) reduces monocyte infection rates and cytokine levels caused by Dengue Virus-2. Mar 01, 2008

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2008 Mar;8(3):468-76. Epub 2007 Dec 26. PMID: 18279801

Article Published Date : Mar 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Cat's Claw

Diseases : Dengue Fever, Virally-Induced Cytokine Storm

Pharmacological Actions : Antiviral Agents, Immunomodulatory, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Cytokine Modulation

[+]

Vitamin D and L-cysteine could be useful in preventing the 'cytokine storm,' one of the most severe consequences of infection with COVID-19.Jul 12, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Am Coll Nutr. 2020 Jul 13:1-6. Epub 2020 Jul 13. PMID: 32659175

Article Published Date : Jul 12, 2020

Study Type : Review

Additional Links

Substances : NAC (N-acetyl-L-cysteine), Vitamin D

Additional Keywords : Cytokine Modulation, Cytokine Storm, Risk Reduction

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View the Evidence: 26 Abstracts with Cytokine Modulation Research

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Evidence for possible association of vitamin D status with cytokine storm and unregulated inflammation in COVID-19 patients.Sep 01, 2020

Elderberry stimulates cytokine production in the healthy immune system to fight off viral infection.Apr 01, 2001

The administration of oral maoto granules to healthy adults with seasonal influenza was well tolerated and associated with equivalent clinical and virological efficacy to oseltamivir or zanamivir.Jul 31, 2012

Ascorbate supplementation hinders metastasis, tumor growth and inflammatory cytokine secretion as well as enhanced encapsulation of tumors elicited by melanoma and breast cancer.Dec 31, 2012

Resveratrol relieves symptoms in experimental autoimmune encephalomyelitis, an animal model of Multiple Sclerosis, by modulating cytokines and macrophages. Jan 01, 2009

The administration of probiotic L. casei exerted an anti-inflammatory response in mice fed an high fat diet.Jun 30, 2015

Vitamin E supplementation modulates immune function and cytokine production during a mouse experimental model of virally-induced AIDS. Apr 01, 1995

Δ9-tetrahydrocannabinol prevents mortality from acute respiratory distress syndrome.Aug 27, 2020

Cytokine storm in COVID-19 and parthenolide: Preclinical evidence.May 29, 2020

The importance of vitamin d metabolism as a potential prophylactic, immunoregulatory and neuroprotective treatment for COVID-19.Jan 25, 2020

A systematic review on the effects of Echinacea supplementation on cytokine levels.Jul 28, 2021

Andrographolide could bind with TNF and NFkB1 proteins, block TNF-induced cytokine storm in COVID-19 patients.Dec 31, 2020

Andrographolide may be effective in lowering cytokine storm and treating severe symptoms.Jul 16, 2022

Curcumin suppression of cytokine release and cytokine storm. A potential therapy for patients with Ebola and other severe viral infections.Dec 31, 2014

Echinacea root contains cytokine-modulating capability that may be therapeutic in combating influenza A infections. Jul 01, 2009

L. edodes may have future potential by way of influencing immunotherapies for addressing COVID-19 that rely on reducing cytokine storm.Aug 24, 2020

Low-level laser therapy combined with conventional medical therapy has the potential to prevent the progression of COVID-19.Dec 31, 2019

Mini-Review on the Roles of Vitamin C, Vitamin D, and Selenium in the Immune System against COVID-19.Nov 15, 2020

Natural immunomodulators treat the cytokine storm in SARS-CoV-2.Dec 31, 2022

Probiotics supplementation could reduce the severity of COVID-19 morbidity and mortality.Mar 18, 2021

Saffron represents a promising substance for toning down cytokine storm during COVID-19.Aug 31, 2021

Scutellaria baicalensis (Chinese skullcap) stimulates resistance to viral infection in human leukocytes through the beneficial modulation of cytokines. Sep 01, 2008

The potential for Lactoferrin to reduce SARS-CoV-2 induced cytokine storm.Mar 11, 2021

This study intends to provide reference for clinical use of traditional Chinese medicine to resist new coronavirus.Feb 29, 2020

Uncaria tomentosa (cat's claw) reduces monocyte infection rates and cytokine levels caused by Dengue Virus-2. Mar 01, 2008

Vitamin D and L-cysteine could be useful in preventing the 'cytokine storm,' one of the most severe consequences of infection with COVID-19.Jul 12, 2020

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Cytokine Modulation

View the Evidence:
26 Abstracts with Cytokine Modulation Research