Drug: Doxorubicin

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8 Problem Substances Researched for Drug: Doxorubicin
NameACCKFocus
Chemotherapy110Locked
Tamoxifen110Locked
Bisphosphonates13Locked
Dexamethasone13Locked
Doxorubicin23Locked
Zoledronic Acid13Locked
Cyclophosphamide12Locked
Bisphenol A 11Locked
44 Diseases Researched for Drug: Doxorubicin
NameACCKFocus
Chemotherapy-Induced Toxicity: Doxorubicin1755Locked
Chemotherapy-Induced Toxicity940Locked
Breast Cancer1239Locked
Oxidative Stress627Locked
Cancers: Drug Resistant1626Locked
Lung Cancer717Locked
Chemically-Induced Liver Damage212Locked
Promyelocytic leukemia 312Locked
Chemotherapy-Induced Toxicity: Cisplatin211Locked
Ovarian Cancer211Locked
Chemotherapy-Induced Toxicity: Cyclophosphamide110Locked
Fatty Liver110Locked
Hypertension110Locked
Lymphoma: Mantle Cell 110Locked
Nitrite Toxicity110Locked
Cardiotoxicity: Chemotherapy-Induced48Locked
Cancers: Multi-Drug Resistant77Locked
Cancers: All46Locked
Chemotherapy-Induced Toxicity: Adriamycin36Locked
Liver Cancer46Locked
Kidney Damage: Drug-Induced25Locked
Prostate Cancer45Locked
Leukemia34Locked
Lipid Peroxidation24Locked
Lymphoma24Locked
Tumors23Locked
Androgen Deficiency12Locked
Brain Injury: Hippocampal Damage12Locked
Cataract12Locked
Cognitive Decline/Dysfunction12Locked
Congestive Heart Failure12Locked
DNA damage12Locked
Heart Failure12Locked
Lymph Node Cancer12Locked
Nephropathy12Locked
Pancreatic Cancer22Locked
Breast Cancer: Triple Negative 11Locked
Breast Cancer: estrogen receptor alpha-positive11Locked
Chemotherapy11Locked
Gastric Cancer11Locked
Leukemia: Acute myelogenous leukemia (AML) 11Locked
Melanoma11Locked
Non-Small-Cell Lung Carcinoma11Locked
Uterine Cancer 11Locked
1 Problematic Actions Researched for Drug: Doxorubicin
NameACCKFocus
Chemotherapy212Locked
4 Adverse Pharmacological Actions Researched for Drug: Doxorubicin
NameACCKFocus
Hepatotoxic110Locked
Nephrotoxic13Locked
Neurotoxic12Locked
Chemoresistance upregulation11Locked
48 Substances Researched for Drug: Doxorubicin
NameACCKFocus
Chokeberry220Locked
Curcumin1014Locked
Genistein211Locked
Turkey Tail Mushroom211Locked
Caffeine110Locked
Daidzein110Locked
Isoflavones110Locked
Soy110Locked
Grape Seed Extract35Locked
Oleuropein24Locked
Resveratrol44Locked
Andrographis23Locked
Phellinus Linteus23Locked
Bee Propolis12Locked
Beet22Locked
Caffeic acid phenethyl ester12Locked
Catechin 12Locked
Celery12Locked
Diosgenin12Locked
Fenugreek12Locked
Garlic12Locked
Germanium12Locked
Hazelnut 12Locked
Loquat Seeds12Locked
Milk Thistle12Locked
Parsley12Locked
Sulforaphane22Locked
Taurine12Locked
Tea12Locked
Testosterone12Locked
Apigenin11Locked
Berberine11Locked
Black Cohosh11Locked
Cashew11Locked
Catechols11Locked
Chrysin11Locked
Coriolus versicolor11Locked
Cucurbitacin D11Locked
Flavonoids11Locked
Lion's Mane (Hericium Erinaceus)11Locked
Parthenolide11Locked
Quercetin11Locked
Rosemaric Acid11Locked
Rosemary11Locked
Sesamol11Locked
Theanine11Locked
Ursolic Acid11Locked
Wogonin11Locked
1 Therapeutic Actions Researched for Drug: Doxorubicin
NameACCKFocus
Exercise110Locked
28 Pharmacological Actions Researched for Drug: Doxorubicin
NameACCKFocus
Antioxidants1239Locked
Antineoplastic Agents1030Locked
Chemosensitizer1627Locked
Chemoprotective Agents321Locked
Apoptotic1819Locked
Antiproliferative 1012Locked
Chemotherapeutic312Locked
Superoxide Dismutase Up-regulation110Locked
Cell cycle arrest88Locked
Anticarcinogenic Agents45Locked
NF-kappaB Inhibitor55Locked
Cardioprotective24Locked
Renoprotective24Locked
Anti-Apoptotic12Locked
Antihypertensive Agents12Locked
Genoprotective12Locked
Glutathione Upregulation 12Locked
Hepatoprotective12Locked
Tumor Suppressor Protein p53 Upregulation22Locked
β(2)-adrenoceptor up-regulation12Locked
Anti-Inflammatory Agents11Locked
Cyclooxygenase Inhibitors11Locked
Enzyme Inhibitors11Locked
Estrogen Receptor Modulators11Locked
Heat Shock Protein Inducer11Locked
Interleukin-6 Downregulation11Locked
Lipoxygenase Inhibitors11Locked
STAT3 Inhibitor11Locked

View the Evidence:
67 Abstracts with Drug: Doxorubicin Research

[+]

A. melanocarpa may be regarded as a promising new source of bioactive antioxidant natural compounds for breast cancer patients.Feb 28, 2013

Pubmed Data : Food Chem Toxicol. 2013 Mar ;53:126-32. Epub 2012 Dec 5. PMID: 23220617
Article Published Date : Feb 28, 2013
Study Type : Human Study
Additional Links
Substances : Chokeberry
Diseases : Breast Cancer, Chemotherapy-Induced Toxicity, Nitrite Toxicity, Oxidative Stress
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Chemotherapeutic
Additional Keywords : Drug: Doxorubicin, Plant Extracts
[+]

Acute exercise protects against doxorubicin cardiotoxicity.Sep 01, 2008

Pubmed Data : Integr Cancer Ther. 2008 Sep;7(3):147-54. PMID: 18815146
Article Published Date : Sep 01, 2008
Study Type : Human Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity, Chemotherapy-Induced Toxicity: Doxorubicin, Hypertension, Oxidative Stress
Therapeutic Actions : Exercise
Additional Keywords : Drug: Doxorubicin
[+]

Caffeine potentiates chemotherapy for metastatic osteosarcoma.Sep 01, 2009

Pubmed Data : J Orthop Sci. 2009 Sep;14(5):556-65. Epub 2009 Oct 3. PMID: 19802667
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Substances : Caffeine
Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Lung Cancer
Pharmacological Actions : Antineoplastic Agents, Chemosensitizer
Additional Keywords : Drug: Doxorubicin, Drug Synergy
[+]

Exercise preconditioning protects against doxorubicin-induced cardiac dysfunction.Oct 05, 2006

Pubmed Data : Vet Microbiol. 2006 Oct 5;117(1):59-65. PMID: 18408619
Article Published Date : Oct 05, 2006
Study Type : Human Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity, Chemotherapy-Induced Toxicity: Doxorubicin
Additional Keywords : Drug: Doxorubicin
[+]

Fermented soy therapy may have therapeutic value in treating platinum-resistant ovarian cancer. Jan 01, 2006

Pubmed Data : Gynecol Oncol. 2006 Jan;100(1):205-9. Epub 2005 Sep 19. PMID: 16171852
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Substances : Daidzein, Genistein, Isoflavones, Soy
Diseases : Cancers: Drug Resistant, Ovarian Cancer
Additional Keywords : Drug: Doxorubicin
[+]

Intensive treatment strategies may not provide superior outcomes in mantle cell lymphoma. Jul 01, 2008

Pubmed Data : Ann Oncol. 2008 Jul ;19(7):1327-30. Epub 2008 Mar 17. PMID: 18349031
Article Published Date : Jul 01, 2008
Study Type : Human Study
Additional Links
Diseases : Lymphoma: Mantle Cell
Pharmacological Actions : Antineoplastic Agents
Additional Keywords : Drug: Doxorubicin
Anti Therapeutic Actions : Chemotherapy
Problem Substances : Chemotherapy
[+]

Our results suggest that the Aronia extract supplementation in breast cancer patients has a beneficial effect on thiols concentration in plasma. Dec 31, 2012

Pubmed Data : Mol Cell Biochem. 2013 Jan ;372(1-2):47-55. Epub 2012 Sep 5. PMID: 22949034
Article Published Date : Dec 31, 2012
Study Type : Human Study
Additional Links
Substances : Chokeberry
Diseases : Breast Cancer, Chemotherapy-Induced Toxicity: Cyclophosphamide, Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Superoxide Dismutase Up-regulation
Additional Keywords : Drug: Doxorubicin, Plant Extracts
[+]

Tamoxifen treatment for breast cancer may result in fatty liver.Nov 01, 2000

Pubmed Data : Oncol Rep. 2000 Nov-Dec;7(6):1299-304. PMID: 11032933
Article Published Date : Nov 01, 2000
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Fatty Liver
Additional Keywords : Drug: 5-flourouracil, Drug: Doxorubicin, Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Hepatotoxic
[+]

Turkey tail mushroom contains a polysaccharopeptide which demonstrates chemotherapeutic activity against both leukemic and breast cancer cells.Mar 01, 2008

Pubmed Data : Int J Oncol. 2008 Mar;32(3):689-99 PMID: 18292947
Article Published Date : Mar 01, 2008
Study Type : Human Study
Additional Links
Substances : Turkey Tail Mushroom
Diseases : Breast Cancer, Promyelocytic leukemia
Additional Keywords : Drug: Doxorubicin, Drug-Plant-Vitamin Synergies
[+]

A case of acute kidney injury related to intravenous zoledronic acid in a patient with multiple myeloma has been reported.Jan 01, 2009

Pubmed Data : Nippon Jinzo Gakkai Shi. 2009;51(5):557-62. PMID: 19715164
Article Published Date : Jan 01, 2009
Study Type : Human: Case Report
Additional Links
Diseases : Kidney Damage: Drug-Induced
Additional Keywords : Drug: Doxorubicin
Problem Substances : Bisphosphonates, Dexamethasone, Zoledronic Acid
Adverse Pharmacological Actions : Nephrotoxic
[+]

"Impaired cognitive function and hippocampal neurogenesis following cancer chemotherapy."Feb 14, 2012

Pubmed Data : Clin Cancer Res. 2012 Feb 14. Epub 2012 Feb 14. PMID: 22338017
Article Published Date : Feb 14, 2012
Study Type : Animal Study
Additional Links
Diseases : Brain Injury: Hippocampal Damage, Chemotherapy-Induced Toxicity, Chemotherapy-Induced Toxicity: Doxorubicin, Cognitive Decline/Dysfunction
Additional Keywords : Drug: Doxorubicin
Anti Therapeutic Actions : Chemotherapy
Problem Substances : Cyclophosphamide, Doxorubicin
Adverse Pharmacological Actions : Neurotoxic
[+]

Aged garlic extract and grape seed proanthocyanidin protect against doxorubicin-induced cardiotoxicity.Aug 01, 2009

Pubmed Data : Can J Physiol Pharmacol. 2009 Aug;87(8):633-40. PMID: 19767888
Article Published Date : Aug 01, 2009
Study Type : Animal Study
Additional Links
Substances : Garlic, Grape Seed Extract
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants
Additional Keywords : Drug: Doxorubicin, Plant Extracts, Proanthocyanidins
[+]

Andrographis may be more effective an anticancer agent than Doxorubicin in lymphoma. Dec 01, 2008

Pubmed Data : Mol Biol Rep. 2008 Dec;35(4):535-40. Epub 2007 Sep 5. PMID: 17805989
Article Published Date : Dec 01, 2008
Study Type : Animal Study
Additional Links
Substances : Andrographis
Diseases : Lymph Node Cancer, Lymphoma
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants
Additional Keywords : Drug: Doxorubicin, Plant Extracts, Superiority of Natural Substances versus Drugs
[+]

Caffeic acid phenetyl ester, a compound found within bee propolis, protects against doxorubucin-induced cardiotoxicity in rats. Sep 30, 2010

Pubmed Data : Am J Ind Med. 2010 Sep 30. Epub 2010 Sep 30. PMID: 14745846
Article Published Date : Sep 30, 2010
Study Type : Animal Study
Additional Links
Substances : Bee Propolis, Caffeic acid phenethyl ester
Diseases : Cardiotoxicity: Chemotherapy-Induced, Chemotherapy-Induced Toxicity, Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants
Additional Keywords : Drug: Doxorubicin
[+]

Celery has a protective effect against doxorubicin toxicity. Jan 01, 2009

Pubmed Data : Molecules. 2009 ;14(4):1627-38. Epub 2009 Apr 24. PMID: 19396021
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Celery
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Lipid Peroxidation
Pharmacological Actions : Antioxidants
Additional Keywords : Drug: Doxorubicin, Plant Extracts
[+]

Curcumin attenuates acute adriamycin myocardial toxicity in rats.Jun 01, 1998

Pubmed Data : Br J Pharmacol. 1998 Jun;124(3):425-7. PMID: 9647462
Article Published Date : Jun 01, 1998
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Adriamycin
Pharmacological Actions : Cardioprotective
Additional Keywords : Drug: Doxorubicin
[+]

Curcumin can inhibit tumour growth in a xenograft animal model in vivo.Jan 13, 2010

Pubmed Data : Phytother Res. 2010 Jan 13;24(2):189-192. Epub 2010 Jan 13. PMID: 20077433
Article Published Date : Jan 13, 2010
Study Type : Transgenic Animal Study
Additional Links
Substances : Curcumin
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Drug: Doxorubicin, Drug-Plant-Vitamin Synergies
[+]

Curcumin prevents adriamycin nephrotoxicity in rats.Jan 01, 2000

Pubmed Data : Br J Pharmacol. 2000 Jan;129(2):231-4. PMID: 10694226
Article Published Date : Jan 01, 2000
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Adriamycin, Kidney Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Renoprotective
Additional Keywords : Drug: Doxorubicin
[+]

Curcumin protects against doxorubicin (adriamycin)-induced toxicity in rats.Apr 01, 2009

Pubmed Data : J Med Food. 2009 Apr;12(2):394-402. PMID: 19459743
Article Published Date : Apr 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemically-Induced Liver Damage, Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants
Additional Keywords : Drug: Doxorubicin, Drug Side Effect Attenuation, Plant Extracts
[+]

Diosgenin, a compound isolated from fenugreek, has chemosensitizing activity against human liver cancer cells. Jan 04, 2010

Pubmed Data : Cancer Lett. 2010 Jan 4. Epub 2010 Jan 4. PMID: 20053498
Article Published Date : Jan 04, 2010
Study Type : Animal Study
Additional Links
Substances : Diosgenin, Fenugreek
Diseases : Liver Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Drug: Doxorubicin, Drug: Paclitaxel, Drug-Plant-Vitamin Synergies
[+]

Germanium compounds may have therapeutic value in the treatment of various cancers.Apr 01, 1985

Pubmed Data : J Biol Response Mod. 1985 Apr;4(2):159-68. PMID: 3998767
Article Published Date : Apr 01, 1985
Study Type : Animal Study
Additional Links
Substances : Germanium
Diseases : Cancers: All, Leukemia, Lymphoma
Pharmacological Actions : Antineoplastic Agents
Additional Keywords : Drug: Doxorubicin, Drug-Plant-Vitamin Synergies
[+]

Grape seed extract has a protective role against doxorubicin-induced cardiotoxicity and genotoxicity in albino mice.Aug 01, 2010

Pubmed Data : J Med Food. 2010 Aug;13(4):917-25. PMID: 20553142
Article Published Date : Aug 01, 2010
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Cardiotoxicity: Chemotherapy-Induced, Chemotherapy-Induced Toxicity: Doxorubicin, DNA damage
Pharmacological Actions : Cardioprotective, Genoprotective
Additional Keywords : Drug: Doxorubicin
[+]

Green tea catechins augment the antitumor activity of doxorubicin in an in vivo mouse model for chemoresistant liver cancer.Jul 01, 2010

Pubmed Data : Int J Oncol. 2010 Jul ;37(1):111-23. PMID: 20514403
Article Published Date : Jul 01, 2010
Study Type : Animal Study
Additional Links
Substances : Catechin , Tea
Diseases : Cancers: Drug Resistant, Liver Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Drug: Doxorubicin, Drug Synergy
[+]

Hazelnut prevented doxorubicin-induced cataract in low doses.Aug 01, 2005

Pubmed Data : Med Sci Monit. 2005 Aug;11(8):BR300-4. Epub 2005 Jul 25. PMID: 16049376
Article Published Date : Aug 01, 2005
Study Type : Animal Study
Additional Links
Substances : Hazelnut
Diseases : Cataract, Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants
Additional Keywords : Drug: Doxorubicin
[+]

Loquat seed inhibits oxidative stress associated wtih adriamycin-induced nephropathy. Dec 01, 2004

Pubmed Data : Biol Pharm Bull. 2004 Dec;27(12):1961-4. PMID: 15577213
Article Published Date : Dec 01, 2004
Study Type : Animal Study
Additional Links
Substances : Loquat Seeds
Diseases : Chemotherapy-Induced Toxicity: Adriamycin, Lipid Peroxidation, Nephropathy, Oxidative Stress
Pharmacological Actions : Glutathione Upregulation , Renoprotective
Additional Keywords : Drug: Doxorubicin, Plant Extracts
[+]

Oleuropein confers protection against doxorubicin-induced cardiotoxicity. Jul 01, 2009

Pubmed Data : NMR Biomed. 2009 Jul;22(6):585-92. PMID: 19308947
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Substances : Oleuropein
Diseases : Cardiotoxicity: Chemotherapy-Induced, Chemotherapy-Induced Toxicity, Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antihypertensive Agents, Antioxidants
Additional Keywords : Drug: Doxorubicin
[+]

Oleuropein prevents doxorubicin-induced cardiotoxicity and improves therapeutic outcome. Mar 01, 2007

Pubmed Data : J Mol Cell Cardiol. 2007 Mar;42(3):549-58. Epub 2007 Jan 16. PMID: 17223128
Article Published Date : Mar 01, 2007
Study Type : Animal Study
Additional Links
Substances : Oleuropein
Diseases : Cardiotoxicity: Chemotherapy-Induced, Chemotherapy-Induced Toxicity, Chemotherapy-Induced Toxicity: Doxorubicin, Oxidative Stress
Additional Keywords : Drug: Doxorubicin, Drug-Plant-Vitamin Synergies
[+]

Parsley and celery juices restore antioxidant activity in doxorubicin-treated rats.Sep 03, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2010 Sep 3 ;15(9):6193-204. Epub 2010 Sep 3. PMID: 20877216
Article Published Date : Sep 03, 2010
Study Type : Animal Study
Additional Links
Substances : Parsley
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants
Additional Keywords : Drug: Doxorubicin
[+]

Phellinus linteus has a synergistic effect with the drug doxorubicin in prostate cancer. Aug 07, 2006

Pubmed Data : Br J Cancer. 2006 Aug 7;95(3):282-8. Epub 2006 Jul 25. PMID: 16868541
Article Published Date : Aug 07, 2006
Study Type : Animal Study
Additional Links
Substances : Phellinus Linteus
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
Additional Keywords : Drug: Doxorubicin, Drug-Plant-Vitamin Synergies
[+]

Restoration of appropriate testosterone levels may have therapeutic value in the treatment of heart failure.Apr 28, 2011

Pubmed Data : Gen Comp Endocrinol. 2011 Apr 28. Epub 2011 Apr 28. PMID: 21549119
Article Published Date : Apr 28, 2011
Study Type : Animal Study
Additional Links
Substances : Testosterone
Diseases : Androgen Deficiency, Congestive Heart Failure, Heart Failure
Pharmacological Actions : β(2)-adrenoceptor up-regulation
Additional Keywords : Chemotherapy Induced Toxicity, Drug: Doxorubicin
[+]

Silymarin, a compound found within milk thistle, has a protective effect against Doxorubicin-induced oxidative stress and liver damage. Feb 05, 2010

Pubmed Data : Toxicol Appl Pharmacol. 2010 Feb 5. Epub 2010 Feb 5. PMID: 20144634
Article Published Date : Feb 05, 2010
Study Type : Animal Study
Additional Links
Substances : Milk Thistle
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective
Additional Keywords : Drug: Doxorubicin
[+]

Taurine potentiates the antitumor activity of doxorubicin. Sep 01, 2009

Pubmed Data : Biol Pharm Bull. 2009 Sep;32(9):1584-7. PMID: 19721236
Article Published Date : Sep 01, 2009
Study Type : Animal Study
Additional Links
Substances : Taurine
Diseases : Cancers: All, Tumors
Additional Keywords : Drug: Doxorubicin, Drug-Plant-Vitamin Synergies
[+]

Andrographis contains a compound which enhances chemosensitivity of cancer cells to doxorubicin.May 01, 2010

Pubmed Data : Biochem Pharmacol. 2010 May 1;79(9):1242-50. Epub 2009 Dec 21. PMID: 20026083
Article Published Date : May 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Andrographis
Diseases : Cancers: All
Pharmacological Actions : Apoptotic, Chemosensitizer
Additional Keywords : Drug: Doxorubicin, Drug-Plant-Vitamin Synergies
[+]

Apigenin may have a therapeutic role in the treatment of multi-drug resistant cancers. Sep 10, 2009

Pubmed Data : J Med Chem. 2009 Sep 10;52(17):5311-22. PMID: 19725578
Article Published Date : Sep 10, 2009
Study Type : In Vitro Study
Additional Links
Substances : Apigenin
Diseases : Cancers: Multi-Drug Resistant
Additional Keywords : Drug: Doxorubicin
[+]

Beetroot extract has 10 times lower toxicity than the chemo-agent doxorubicin; it has anti-cancer properties against breast and prostate cancer cells.Feb 28, 2011

Pubmed Data : Anticancer Agents Med Chem. 2011 Mar ;11(3):280-4. PMID: 21434853
Article Published Date : Feb 28, 2011
Study Type : In Vitro Study
Additional Links
Substances : Beet
Diseases : Breast Cancer, Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative
Additional Keywords : Drug: Doxorubicin, Natural Substance Synergy, Plant Extracts
[+]

Berberine increases doxorubicin sensitivity by suppressing STAT3 in lung cancer.Oct 26, 2015

Pubmed Data : Am J Chin Med. 2015 Oct 27:1-16. Epub 2015 Oct 27. PMID: 26503561
Article Published Date : Oct 26, 2015
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Lung Cancer
Pharmacological Actions : Chemosensitizer, STAT3 Inhibitor
Additional Keywords : Drug: Doxorubicin
[+]

Black cohosh potentiates the antiproliferative effects of chemotherapy agents on human breast cancer cells. Oct 01, 2006

Pubmed Data : Planta Med. 2006 Oct;72(13):1200-6. Epub 2006 Sep 20. PMID: 16988912
Article Published Date : Oct 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Black Cohosh
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest
Additional Keywords : Drug: Doxorubicin, Drug-Plant-Vitamin Synergies
[+]

BPA at environmentally relevant doses reduces the efficacy of chemotherapeutic agents doxorubicin, cisplatin, and vinblastine.Jan 31, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Health Perspect. 2009 Feb ;117(2):175-80. Epub 2008 Oct 8. PMID: 19270784
Article Published Date : Jan 31, 2009
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer, Breast Cancer: estrogen receptor alpha-positive, Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic, Estrogen Receptor Modulators
Additional Keywords : Drug: Cisplatin, Drug: Doxorubicin, Drug: Vinblastine
Problem Substances : Bisphenol A
Adverse Pharmacological Actions : Chemoresistance upregulation
[+]

Cashew contains an anticancer catechol with activity against multidrug resistant cancer cell lines.Apr 21, 2009

Pubmed Data : J Ethnopharmacol. 2009 Apr 21;122(3):450-6. Epub 2009 Feb 10. PMID: 19429311
Article Published Date : Apr 21, 2009
Study Type : In Vitro Study
Additional Links
Substances : Cashew, Catechols
Diseases : Cancers: Multi-Drug Resistant, Leukemia, Tumors
Pharmacological Actions : Apoptotic, Cell cycle arrest
Additional Keywords : Drug: Doxorubicin, Drug-Plant-Vitamin Synergies, Plant Extracts
[+]

Cucurbitacin D decreases cell proliferation and induces apoptosis in doxorubicin-resistant breast cancer cells.Oct 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Cell Biochem. 2015 Nov ;409(1-2):33-43. Epub 2015 Jul 14. PMID: 26169986
Article Published Date : Oct 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin D
Diseases : Breast Cancer, Cancers: Drug Resistant
Pharmacological Actions : Antiproliferative , Apoptotic, Chemotherapeutic, NF-kappaB Inhibitor
Additional Keywords : Drug: Doxorubicin
[+]

Curcumin down-regulates multidrug-resistance. Jan 18, 2008

Pubmed Data : Cancer Lett. 2008 Jan 18;259(1):111-8. Epub 2007 Nov 19. PMID: 18006147
Article Published Date : Jan 18, 2008
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant
Pharmacological Actions : NF-kappaB Inhibitor
Additional Keywords : Drug: Doxorubicin
[+]

Curcumin enhances the effectiveness of doxorubicin. Oct 31, 2011

Pubmed Data : Pharmazie. 2011 Nov ;66(11):871-4. PMID: 22204133
Article Published Date : Oct 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity
Pharmacological Actions : Chemosensitizer
Additional Keywords : Drug: Doxorubicin, Drug Synergy
Problem Substances : Doxorubicin
[+]

Curcumin has antiproliferative effects against human breast tumor cell lines.Jun 01, 1997

Pubmed Data : Anticancer Drugs. 1997 Jun;8(5):470-81. PMID: 9215611
Article Published Date : Jun 01, 1997
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Breast Cancer, Cancers: Drug Resistant, Cancers: Multi-Drug Resistant
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Cell cycle arrest
Additional Keywords : Drug: Doxorubicin
[+]

Curcumin inhibits the growth of breast cancer through the manipulation of the arachidonate metabolism. Jan 01, 2007

Pubmed Data : BMC Cancer. 2007;7:138. Epub 2007 Jul 25. PMID: 17651499
Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Breast Cancer, Cancers: Drug Resistant
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase Inhibitors, Lipoxygenase Inhibitors
Additional Keywords : Drug: Doxorubicin
[+]

Curcumin reduces multi-drug resistance in uterine cancer cells.Oct 01, 2008

Pubmed Data : Oncol Rep. 2008 Oct;20(4):731-5. PMID: 18813811
Article Published Date : Oct 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cancers: Multi-Drug Resistant, Uterine Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer
Additional Keywords : Drug: Doxorubicin
[+]

Curcumin reduces NF-kappa B factor activation associated with anticancer drugs. Dec 01, 2009

Pubmed Data : Endocr Relat Cancer. 2009 Dec;16(4):1339-50. Epub 2009 Sep 2. PMID: 12007574
Article Published Date : Dec 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy, Chemotherapy-Induced Toxicity
Pharmacological Actions : Antineoplastic Agents, NF-kappaB Inhibitor
Additional Keywords : Drug: Doxorubicin, Drug: Tamoxifen
[+]

Genistein acts as a chemosensitzer, contributing to overcoming drug-resistance in prostate, breast, lung and pancreatic ancers. Aug 01, 2005

Pubmed Data : Cancer Res. 2005 Aug 1;65(15):6934-42. PMID: 16061678
Article Published Date : Aug 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Genistein
Diseases : Breast Cancer, Cancers: Drug Resistant, Chemotherapy-Induced Toxicity: Cisplatin, Lung Cancer, Pancreatic Cancer, Prostate Cancer
Pharmacological Actions : Apoptotic, NF-kappaB Inhibitor
Additional Keywords : Drug: Doxorubicin, Drug-Plant-Vitamin Synergies
[+]

Grape seed extract and the conventional cytotoxic agent doxorubicin have a synergistic effect against human breast cancer cells. May 01, 2004

Pubmed Data : Breast Cancer Res Treat. 2004 May;85(1):1-12. PMID: 15039593
Article Published Date : May 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Grape Seed Extract
Diseases : Breast Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
Additional Keywords : Drug: Doxorubicin, Drug-Plant-Vitamin Synergies, Plant Extracts
[+]

Lion's main enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells.Nov 28, 2010

Pubmed Data : Cancer Lett. 2010 Nov 28 ;297(2):144-54. PMID: 20554107
Article Published Date : Nov 28, 2010
Study Type : In Vitro Study
Additional Links
Substances : Lion's Mane (Hericium Erinaceus)
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer
Additional Keywords : Drug: Doxorubicin
[+]

Parthenolide reverses doxorubicin resistance in human lung carcinoma A549 cells.Aug 13, 2013

Pubmed Data : Toxicol Lett. 2013 Aug 14 ;221(2):73-82. Epub 2013 Jun 20. PMID: 23792430
Article Published Date : Aug 13, 2013
Study Type : In Vitro Study
Additional Links
Substances : Parthenolide
Diseases : Cancers: Drug Resistant, Lung Cancer
Pharmacological Actions : Chemotherapeutic, Heat Shock Protein Inducer, NF-kappaB Inhibitor
Additional Keywords : Drug: Doxorubicin
[+]

Quercetin induces programmed cell death in human myeloid leukemia cells and their doxorubicin resistant variants. Jan 01, 2005

Pubmed Data : Neoplasma. 2005;52(4):273-9. PMID: 16059641
Article Published Date : Jan 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Cancers: Drug Resistant, Promyelocytic leukemia
Pharmacological Actions : Apoptotic
Additional Keywords : Drug: Doxorubicin
[+]

Resveratrol attenuates doxorubicin-induced cellular damage by modulating nitric oxide and apoptosis.Dec 06, 2010

Pubmed Data : Exp Toxicol Pathol. 2010 Dec 6. Epub 2010 Dec 6. PMID: 21144718
Article Published Date : Dec 06, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Apoptotic
Additional Keywords : Drug: Doxorubicin
[+]

Resveratrol induces cell-cycle disruption and programmed cell death in chemoresistant melanoma.Jul 01, 2010

Pubmed Data : J Cell Biochem. 2010 Jul 1;110(4):893-902. PMID: 20564188
Article Published Date : Jul 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Cancers: Drug Resistant, Melanoma
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Chemosensitizer
Additional Keywords : Drug: Doxorubicin, Stilbenes
[+]

Resveratrol reverses doxorubicin resistance in acute myeloid leukemia cells.Jan 01, 2008

Pubmed Data : Environ Health. 2008;7:21. Epub 2008 May 30. PMID: 20350534
Article Published Date : Jan 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Drug: Doxorubicin, Stilbenes
[+]

Resveratrol sensitizes resistant leukemia cells to the the effects of anticancer drugs. Jan 01, 2006

Pubmed Data : Neoplasma. 2006;53(5):384-92. PMID: 17013532
Article Published Date : Jan 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Leukemia
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Cell cycle arrest, Chemosensitizer
Additional Keywords : Drug: Doxorubicin, Stilbenes
[+]

Reversal effect of rosmarinic acid on multidrug resistance in gastric cancer cells.Dec 31, 2012

Pubmed Data : J Asian Nat Prod Res. 2013 ;15(3):276-85. Epub 2013 Feb 19. PMID: 23421517
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Rosemaric Acid, Rosemary
Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant, Gastric Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Drug: Doxorubicin
[+]

Review: Genetic and epigenetic modeling of the origins of multidrug-resistant cells in a human sarcoma cell line.Oct 15, 2005

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Res. 2005 Oct 15 ;65(20):9388-97. PMID: 16230402
Article Published Date : Oct 15, 2005
Study Type : Review
Additional Links
Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant
Additional Keywords : Drug: Doxorubicin, Multidrug Resistance
[+]

Sufloraphane reduces doxorubicin resistance.Oct 10, 2006

Pubmed Data : Mutat Res. 2006 Oct 10;601(1-2):92-101. Epub 2006 Jul 14. PMID: 16843502
Article Published Date : Oct 10, 2006
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Cancers: Drug Resistant
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Chemosensitizer, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Drug: Doxorubicin, Drug-Plant-Vitamin Synergies
[+]

Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines.Dec 31, 2012

Pubmed Data : J Complement Integr Med. 2013 ;10(1):1-10. Epub 2013 Jun 26. PMID: 23828331
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Beet
Diseases : Breast Cancer, Cancers: Drug Resistant, Pancreatic Cancer, Prostate Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Drug: Doxorubicin, Natural Substance/Drug Synergy
[+]

The association of sulforaphane-doxorubicin may therefore allow doxorubicin to be administered at lower doses, thereby reducing its potential toxicity.Jan 01, 2007

Pubmed Data : Ann N Y Acad Sci. 2007 Jan;1095:62-9. PMID: 17404018
Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Anticarcinogenic Agents, Chemosensitizer, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Drug: Doxorubicin, Drug-Plant-Vitamin Synergies
[+]

The mushroom Phellinus Linteus induces programmed cell death and arrests growth in human lung cancer cells. Feb 01, 2007

Pubmed Data : Mol Carcinog. 2007 Feb;46(2):144-54. PMID: 17131292
Article Published Date : Feb 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Phellinus Linteus
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Drug: Doxorubicin
[+]

Theanine enhances the antitumor efficacy of chemotherapeutic agents. Dec 05, 2003

Pubmed Data : Biochim Biophys Acta. 2003 Dec 5;1653(2):47-59. PMID: 14643924
Article Published Date : Dec 05, 2003
Study Type : Review
Additional Links
Substances : Theanine
Diseases : Cancers: All, Ovarian Cancer
Pharmacological Actions : Antineoplastic Agents, Enzyme Inhibitors
Additional Keywords : Drug: Doxorubicin, Drug-Plant-Vitamin Synergies
[+]

This data showed a synergistic inhibitory effect of manuka honey on doxorubicin-mediated apoptotic cell death in liver cancer cells.May 27, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Res. 2021 May 28 ;54(1):16. Epub 2021 May 28. PMID: 34049576
Article Published Date : May 27, 2021
Study Type : In Vitro Study
Additional Links
Substances : Honey
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Drug: Doxorubicin
[+]

This reflects the significance of sesamol in ameliorating the deleterious effects associated with cancer chemotherapy.Jun 30, 2013

Pubmed Data : J Pharm Pharmacol. 2013 Jul ;65(7):1083-93. Epub 2013 Apr 22. PMID: 23738736
Article Published Date : Jun 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Oxidative Stress
Pharmacological Actions : Antioxidants, Chemoprotective Agents
Additional Keywords : Drug: Doxorubicin
[+]

Turkey tail mushroom (C. versicolor) potentiates the anti-cancer activity of the chemotherapy drugs doxorubicin and etoposide against human promyelocytic leukemia cells. Jul 01, 2005

Pubmed Data : Oncol Rep. 2005 Jul;14(1):145-55. PMID: 15944782
Article Published Date : Jul 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Coriolus versicolor, Turkey Tail Mushroom
Diseases : Promyelocytic leukemia
Pharmacological Actions : Apoptotic, Cell cycle arrest
Additional Keywords : Drug: Doxorubicin, Drug: Etoposide, Drug-Plant-Vitamin Synergies
[+]

Ursolic acid induces doxorubicin-resistant liver cancer cell death.Dec 01, 2010

Pubmed Data : Cancer Lett. 2010 Dec 1;298(1):128-38. Epub 2010 Jul 13. PMID: 20630652
Article Published Date : Dec 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Ursolic Acid
Diseases : Cancers: Drug Resistant, Liver Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Drug: Doxorubicin
[+]

Wogonin and chrysin may contribute to overcoming drug resistance in non-small cell lung cancer cells. May 01, 2007

Pubmed Data : Int J Cancer. 2007 May 1;120(9):2019-27. PMID: 17266043
Article Published Date : May 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Chrysin, Flavonoids, Wogonin
Diseases : Cancers: Drug Resistant, Lung Cancer, Non-Small-Cell Lung Carcinoma
Pharmacological Actions : Apoptotic, Cell cycle arrest, Interleukin-6 Downregulation
Additional Keywords : Drug: Doxorubicin

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