Drug: Indomethacin

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3 Problem Substances Researched for Drug: Indomethacin
NameACCKFocus
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)36Locked
Alendronate (trade name Fosamax) 12Locked
Freund adjuvant12Locked
20 Diseases Researched for Drug: Indomethacin
NameACCKFocus
Gastric Ulcer918Locked
Drug-Induced Toxicity: Indomethacin815Locked
Oxidative Stress612Locked
NSAID-induced toxicity 510Locked
Inflammation46Locked
Aspirin-Induced Toxicity 24Locked
Duodenal Ulcer24Locked
Pain24Locked
Lipid Peroxidation23Locked
Alcohol Toxicity 12Locked
Gastroduodenal Ulcer12Locked
Infertility12Locked
Lipopolysaccharide-Induced Toxicity12Locked
Mitochondrial Diseases12Locked
Mitochondrial Dysfunction 12Locked
Wound Healing12Locked
Drug-Induced Toxicity 11Locked
Oral Cancer11Locked
Squamous cell carcinoma11Locked
Tongue Cancer11Locked
1 Adverse Pharmacological Actions Researched for Drug: Indomethacin
NameACCKFocus
Inflammatory12Locked
26 Substances Researched for Drug: Indomethacin
NameACCKFocus
Curcumin510Locked
Mussel: Green-lipped (Perna canaliculus)23Locked
Apple12Locked
Argania spinosa (Argan)12Locked
Fructose12Locked
Glucose12Locked
Glutamine12Locked
Honey12Locked
Isoliquiritigenin12Locked
Kombucha Tea12Locked
Loquat Seeds12Locked
Maltose12Locked
Mangiferin12Locked
Melatonin12Locked
Moringa oleifera12Locked
Polyphenols12Locked
Resveratrol22Locked
Stilbenes22Locked
Sucrose12Locked
Tea12Locked
Water: Deep Sea12Locked
Whey12Locked
Fish Oil11Locked
Lichens11Locked
Quercetin11Locked
Sulforaphane11Locked
15 Pharmacological Actions Researched for Drug: Indomethacin
NameACCKFocus
Gastroprotective714Locked
Antioxidants713Locked
Anti-Inflammatory Agents610Locked
Anti-Ulcer Agents510Locked
Analgesics36Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor24Locked
Cyclooxygenase Inhibitors22Locked
Cytoprotective12Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor12Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor12Locked
Antiproliferative 11Locked
Cyclooxygenase 1 Inhibitor11Locked
Cyclooxygenase 2 Inhibitors11Locked
Prostaglandin H Synthase-1 (PGHS-1) Inhibits11Locked
Prostaglandin H Synthase-2 (PGHS-2) Up-Regulation11Locked

View the Evidence:
26 Abstracts with Drug: Indomethacin Research

[+]

Alendronate impairs the healing of gastric ulcers in rats.Aug 01, 2007

Pubmed Data : Dig Dis Sci. 2007 Aug;52(8):1879-89. Epub 2007 Apr 5. PMID: 17410434
Article Published Date : Aug 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Gastric Ulcer
Additional Keywords : Drug: Indomethacin
Problem Substances : Alendronate (trade name Fosamax)
[+]

An apple peel polyphenol extract protected cells against the indomethacin-associated adverse effects in vivo.Nov 08, 2011

Pubmed Data : J Agric Food Chem. 2011 Nov 9 ;59(21):11501-8. Epub 2011 Oct 6. PMID: 21954913
Article Published Date : Nov 08, 2011
Study Type : Animal Study
Additional Links
Substances : Apple, Polyphenols
Diseases : Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Cytoprotective
Additional Keywords : Drug: Indomethacin
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Analgesic and anti-inflammatory activity of saponins of Argania spinozaDec 31, 1997

Pubmed Data : Ann Pharm Fr. 1998 ;56(5):220-8. PMID: 9805822
Article Published Date : Dec 31, 1997
Study Type : Animal Study
Additional Links
Substances : Argania spinosa (Argan)
Diseases : Inflammation, Pain
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents
Additional Keywords : Drug: Indomethacin
[+]

Comparative healing property of kombucha tea and black tea against indomethacin-induced gastric ulceration in mice: possible mechanism of action.Nov 30, 2010

Pubmed Data : Food Funct. 2010 Dec ;1(3):284-93. Epub 2010 Nov 3. PMID: 21776478
Article Published Date : Nov 30, 2010
Study Type : Animal Study
Additional Links
Substances : Kombucha Tea, Tea
Diseases : Drug-Induced Toxicity: Indomethacin, Gastric Ulcer, NSAID-induced toxicity , Oxidative Stress, Wound Healing
Pharmacological Actions : Anti-Ulcer Agents, Antioxidants
Additional Keywords : Drug: Indomethacin, Drug: Omeprazole, Plant Extracts
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction.Jul 01, 2008

Pubmed Data : Arch Toxicol. 2008 Jul;82(7):471-81. Epub 2007 Nov 30. PMID: 18060385
Article Published Date : Jul 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Drug-Induced Toxicity: Indomethacin, Mitochondrial Diseases, Mitochondrial Dysfunction , NSAID-induced toxicity , Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Drug: Indomethacin
[+]

Curcumin protects against indomethacin-induced gastric injury. Oct 01, 2009

Pubmed Data : Anticancer Drugs. 2009 Oct;20(9):757-69. PMID: 16631530
Article Published Date : Oct 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Drug-Induced Toxicity: Indomethacin, Gastric Ulcer
Pharmacological Actions : Gastroprotective
Additional Keywords : Drug: Indomethacin
[+]

Curcumin reduces indomethacin-induced damage in the rat small intestine.Nov 15, 2010

Pubmed Data : Cancer Res. 2010 Nov 15;70(22):9218-23. Epub 2010 Oct 26. PMID: 17351913
Article Published Date : Nov 15, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Duodenal Ulcer, Oxidative Stress
Pharmacological Actions : Anti-Ulcer Agents, Antioxidants
Additional Keywords : Drug: Indomethacin
[+]

Curcumin's antiulcer activity is primarily attributed to MMP-9 inhibition, one of the major path-ways of ulcer healing.Mar 11, 2005

Pubmed Data : J Biol Chem. 2005 Mar 11;280(10):9409-15. Epub 2004 Dec 22. PMID: 15615723
Article Published Date : Mar 11, 2005
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Gastric Ulcer, Oxidative Stress
Pharmacological Actions : Anti-Ulcer Agents, Gastroprotective, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords : Drug: Indomethacin
[+]

Gastroprotective activities of ethanol extract of black rice bran.Jun 21, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Jun 22 ;26(13). Epub 2021 Jun 22. PMID: 34206628
Article Published Date : Jun 21, 2021
Study Type : Animal Study
Additional Links
Substances : Rice Bran
Diseases : Alcohol Toxicity , Gastric Ulcer
Pharmacological Actions : Anti-Ulcer Agents, Gastrointestinal Agents
Additional Keywords : Drug: Indomethacin, Phytotherapy, Plant Extracts
[+]

Gastroprotective effects of Spirulina platensis, golden kiwifruit flesh, and golden kiwifruit peel extracts.Oct 02, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2021 Oct 3 ;13(10). Epub 2021 Oct 3. PMID: 34684501
Article Published Date : Oct 02, 2021
Study Type : Animal Study
Additional Links
Substances : Kiwifruit, Spirulina
Diseases : Gastric Ulcer
Pharmacological Actions : Anti-Ulcer Agents, Gastroprotective
Additional Keywords : Drug: Indomethacin, Phytotherapy, Plant Extracts
[+]

Green mussel extract exhibits anti-inflammatory and gastroprotective properties.Jan 01, 1980

Pubmed Data : Arzneimittelforschung. 1980;30(12):2128-32. PMID: 7194074
Article Published Date : Jan 01, 1980
Study Type : Animal Study
Additional Links
Substances : Mussel: Green-lipped (Perna canaliculus)
Diseases : Aspirin-Induced Toxicity , Drug-Induced Toxicity: Indomethacin, Gastric Ulcer, NSAID-induced toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Gastroprotective
Additional Keywords : Drug: Indomethacin
[+]

Honey and a glucose-fructose-sucrose-maltose mixture against ethanol-, indomethacin-, and acidified aspirin-induced lesions in the rat.Nov 01, 2002

Pubmed Data : Exp Toxicol Pathol. 2002 Nov;54(3):217-21. PMID: 12484559
Article Published Date : Nov 01, 2002
Study Type : Animal Study
Additional Links
Substances : Fructose, Glucose, Honey, Maltose, Sucrose
Diseases : Alcohol Toxicity , Aspirin-Induced Toxicity , Gastric Ulcer, NSAID-induced toxicity
Pharmacological Actions : Gastroprotective
Additional Keywords : Drug: Indomethacin
[+]

Isoliquiritigenin prevented the occurrence of gastric ulcers by indomethacin.Apr 30, 2015

Pubmed Data : Planta Med. 2015 May ;81(7):586-93. Epub 2015 Apr 15. PMID: 25875506
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Substances : Isoliquiritigenin
Diseases : Gastric Ulcer
Pharmacological Actions : Anti-Ulcer Agents, Gastroprotective
Additional Keywords : Drug: Indomethacin, Phytotherapy, Plant Extracts
[+]

Loquat seed extract and deep sea water protect against NSAID-induced gastric injury in rats.Jan 01, 2011

Pubmed Data : J Nat Med. 2011 Jan;65(1):9-17. Epub 2010 Jul 17. PMID: 20640522
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Substances : Loquat Seeds, Water: Deep Sea
Diseases : Drug-Induced Toxicity: Indomethacin, NSAID-induced toxicity
Pharmacological Actions : Gastroprotective
Additional Keywords : Drug: Indomethacin, Plant Extracts
[+]

Mangifera indica exhibits ant-inflammatory properties.Aug 01, 2004

Pubmed Data : Pharmacol Res. 2004 Aug;50(2):143-9. PMID: 15177302
Article Published Date : Aug 01, 2004
Study Type : Animal Study
Additional Links
Substances : Mangiferin
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Pain
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Drug: Indomethacin, Plant Extracts, Xanthones
[+]

Melatonin and curcumin protect against ndomethacin-induced acute gastric ulceration.Sep 15, 2006

Pubmed Data : Free Radic Biol Med. 2006 Sep 15;41(6):911-25. Epub 2006 Apr 30. PMID: 16934674
Article Published Date : Sep 15, 2006
Study Type : Animal Study
Additional Links
Substances : Curcumin, Melatonin
Diseases : Drug-Induced Toxicity: Indomethacin, Gastric Ulcer
Pharmacological Actions : Antioxidants, Gastroprotective, Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords : Drug: Indomethacin
[+]

Moringa oleifera extracts had analgesic, anti-inflammatory, anti-oxidant properties. Aug 31, 2015

Pubmed Data : J Basic Clin Physiol Pharmacol. 2015 Sep 1 ;26(5):491-9. PMID: 26020553
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Drug: Indomethacin, Natural Substances Versus Drugs
[+]

Oral glutamine attenuates indomethacin-induced small intestinal damage.Sep 01, 2004

Pubmed Data : Clin Sci (Lond). 2004 Sep;107(3):281-9. PMID: 15128285
Article Published Date : Sep 01, 2004
Study Type : Animal Study
Additional Links
Substances : Glutamine
Diseases : Duodenal Ulcer, Gastroduodenal Ulcer, Oxidative Stress
Additional Keywords : Drug: Indomethacin
[+]

The vaccine ingredient Freund's adjuvant is used to induce arthritis in rat experiments - Article 2. Dec 01, 2009

Pubmed Data : J Physiol Pharmacol. 2009 Dec;60(4):147-55. PMID: 20065509
Article Published Date : Dec 01, 2009
Study Type : Animal Study
Additional Links
Additional Keywords : Drug: Indomethacin, Vaccine Adjuvant
Problem Substances : Freund adjuvant
Adverse Pharmacological Actions : Inflammatory
[+]

This review summarizes the ovulatory defects after pharmacologic COX-2 inhibition, and discusses the possible mechanisms underlying the anti-ovulatory actions of NSAIDs.Apr 30, 2006

Pubmed Data : Histol Histopathol. 2006 May ;21(5):541-56. PMID: 16493584
Article Published Date : Apr 30, 2006
Study Type : Animal Study
Additional Links
Diseases : Infertility
Additional Keywords : Drug: Indomethacin
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Whey protein concentrate protects against ulcerative lesions caused by subcutaneous administration of indomethacin.Jan 01, 2004

Pubmed Data : J Med Food. 2004;7(3):309-14. PMID: 15383224
Article Published Date : Jan 01, 2004
Study Type : Animal Study
Additional Links
Substances : Whey
Diseases : Drug-Induced Toxicity: Indomethacin, Gastric Ulcer
Pharmacological Actions : Anti-Ulcer Agents
Additional Keywords : Drug: Indomethacin
[+]

Extracts of lichen species Peltigera rufescens have anti-inflammatory and antioxidant effects. Dec 31, 2009

Pubmed Data : J Nat Med. 2010 Jan ;64(1):42-9. Epub 2009 Oct 15. PMID: 19830512
Article Published Date : Dec 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Lichens
Diseases : Inflammation, Lipid Peroxidation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Drug: Indomethacin, Plant Extracts
[+]

Green mussel lipid extracts have anti-cyclooxygenase activity superior to fish oil. Mar 01, 2007

Pubmed Data : Comp Biochem Physiol B Biochem Mol Biol. 2007 Mar;146(3):346-56. Epub 2006 Nov 17. PMID: 17197217
Article Published Date : Mar 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Fish Oil, Mussel: Green-lipped (Perna canaliculus)
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
Additional Keywords : Drug: Indomethacin, Green Muscle Lipids Superior to Fish Oil Lipids
[+]

Resveratrol inhibits PGHS-1 and upregulates PGHS-2 synthesis. Jun 01, 1998

Pubmed Data : Prostaglandins Other Lipid Mediat. 1998 Jun;56(2-3):131-43. PMID: 9785383
Article Published Date : Jun 01, 1998
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol, Stilbenes
Pharmacological Actions : Cyclooxygenase Inhibitors, Prostaglandin H Synthase-1 (PGHS-1) Inhibits, Prostaglandin H Synthase-2 (PGHS-2) Up-Regulation
Additional Keywords : Drug: Indomethacin
[+]

Resveratrol or a combination of resveratrol and quercetin, in concentrations equivalent to that present in red wines, are effective inhibitors of oral squamous carcinoma cell (SCC-25) growth and proliferation.Jan 01, 2006

Pubmed Data : Basic Clin Pharmacol Toxicol. 2006 Jan;98(1):32-7. PMID: 10211549
Article Published Date : Jan 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Quercetin, Resveratrol, Stilbenes
Diseases : Oral Cancer, Squamous cell carcinoma, Tongue Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Drug: Indomethacin, Natural Substance Synergy
[+]

Sulforaphane has protective effect on indomethacin-induced cytoxicity in human intestinal cells.Sep 01, 2009

Pubmed Data : Mol Nutr Food Res. 2009 Sep;53(9):1166-76. PMID: 19653226
Article Published Date : Sep 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Drug-Induced Toxicity , Drug-Induced Toxicity: Indomethacin
Additional Keywords : Drug: Indomethacin

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