Drug: Indomethacin

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3 Problem Substances Researched for Drug: Indomethacin

Name	AC	CK
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	3	6
Alendronate (trade name Fosamax)	1	2
Freund adjuvant	1	2

20 Diseases Researched for Drug: Indomethacin

Name	AC	CK
Gastric Ulcer	9	18
Drug-Induced Toxicity: Indomethacin	8	15
Oxidative Stress	6	12
NSAID-induced toxicity	5	10
Inflammation	4	6
Aspirin-Induced Toxicity	2	4
Duodenal Ulcer	2	4
Pain	2	4
Lipid Peroxidation	2	3
Alcohol Toxicity	1	2
Gastroduodenal Ulcer	1	2
Infertility	1	2
Lipopolysaccharide-Induced Toxicity	1	2
Mitochondrial Diseases	1	2
Mitochondrial Dysfunction	1	2
Wound Healing	1	2
Drug-Induced Toxicity	1	1
Oral Cancer	1	1
Squamous cell carcinoma	1	1
Tongue Cancer	1	1

1 Adverse Pharmacological Actions Researched for Drug: Indomethacin

Name	AC	CK	Focus
Inflammatory	1	2

26 Substances Researched for Drug: Indomethacin

Name	AC	CK
Curcumin	5	10
Mussel: Green-lipped (Perna canaliculus)	2	3
Apple	1	2
Argania spinosa (Argan)	1	2
Fructose	1	2
Glucose	1	2
Glutamine	1	2
Honey	1	2
Isoliquiritigenin	1	2
Kombucha Tea	1	2
Loquat Seeds	1	2
Maltose	1	2
Mangiferin	1	2
Melatonin	1	2
Moringa oleifera	1	2
Polyphenols	1	2
Resveratrol	2	2
Stilbenes	2	2
Sucrose	1	2
Tea	1	2
Water: Deep Sea	1	2
Whey	1	2
Fish Oil	1	1
Lichens	1	1
Quercetin	1	1
Sulforaphane	1	1

15 Pharmacological Actions Researched for Drug: Indomethacin

Name	AC	CK
Gastroprotective	7	14
Antioxidants	7	13
Anti-Inflammatory Agents	6	10
Anti-Ulcer Agents	5	10
Analgesics	3	6
Matrix metalloproteinase-2 (MMP-2) inhibitor	2	4
Cyclooxygenase Inhibitors	2	2
Cytoprotective	1	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	2
Tumor Necrosis Factor (TNF) Alpha Inhibitor	1	2
Antiproliferative	1	1
Cyclooxygenase 1 Inhibitor	1	1
Cyclooxygenase 2 Inhibitors	1	1
Prostaglandin H Synthase-1 (PGHS-1) Inhibits	1	1
Prostaglandin H Synthase-2 (PGHS-2) Up-Regulation	1	1

Research Articles 24
Cumulative Knowledge Score 38
Overall Research Rating GOOD

View the Evidence:
25 Abstracts with Drug: Indomethacin Research

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View the Evidence: 25 Abstracts with Drug: Indomethacin Research

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Alendronate impairs the healing of gastric ulcers in rats.Aug 01, 2007

An apple peel polyphenol extract protected cells against the indomethacin-associated adverse effects in vivo.Nov 08, 2011

Analgesic and anti-inflammatory activity of saponins of Argania spinozaDec 31, 1997

Comparative healing property of kombucha tea and black tea against indomethacin-induced gastric ulceration in mice: possible mechanism of action.Nov 30, 2010

Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction.Jul 01, 2008

Curcumin protects against indomethacin-induced gastric injury. Oct 01, 2009

Curcumin reduces indomethacin-induced damage in the rat small intestine.Nov 15, 2010

Curcumin's antiulcer activity is primarily attributed to MMP-9 inhibition, one of the major path-ways of ulcer healing.Mar 11, 2005

Gastroprotective activities of ethanol extract of black rice bran.Jun 21, 2021

Green mussel extract exhibits anti-inflammatory and gastroprotective properties.Jan 01, 1980

Honey and a glucose-fructose-sucrose-maltose mixture against ethanol-, indomethacin-, and acidified aspirin-induced lesions in the rat.Nov 01, 2002

Isoliquiritigenin prevented the occurrence of gastric ulcers by indomethacin.Apr 30, 2015

Loquat seed extract and deep sea water protect against NSAID-induced gastric injury in rats.Jan 01, 2011

Mangifera indica exhibits ant-inflammatory properties.Aug 01, 2004

Melatonin and curcumin protect against ndomethacin-induced acute gastric ulceration.Sep 15, 2006

Moringa oleifera extracts had analgesic, anti-inflammatory, anti-oxidant properties. Aug 31, 2015

Oral glutamine attenuates indomethacin-induced small intestinal damage.Sep 01, 2004

The vaccine ingredient Freund's adjuvant is used to induce arthritis in rat experiments - Article 2. Dec 01, 2009

This review summarizes the ovulatory defects after pharmacologic COX-2 inhibition, and discusses the possible mechanisms underlying the anti-ovulatory actions of NSAIDs.Apr 30, 2006

Whey protein concentrate protects against ulcerative lesions caused by subcutaneous administration of indomethacin.Jan 01, 2004

Extracts of lichen species Peltigera rufescens have anti-inflammatory and antioxidant effects. Dec 31, 2009

Green mussel lipid extracts have anti-cyclooxygenase activity superior to fish oil. Mar 01, 2007

Resveratrol inhibits PGHS-1 and upregulates PGHS-2 synthesis. Jun 01, 1998

Resveratrol or a combination of resveratrol and quercetin, in concentrations equivalent to that present in red wines, are effective inhibitors of oral squamous carcinoma cell (SCC-25) growth and proliferation.Jan 01, 2006

Sulforaphane has protective effect on indomethacin-induced cytoxicity in human intestinal cells.Sep 01, 2009

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Drug: Indomethacin

View the Evidence:
25 Abstracts with Drug: Indomethacin Research