Drug: Metformin

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7 Problem Substances Researched for Drug: Metformin

Name	AC	CK
Sulfonylureas	6	70
Metformin	5	42
Glibenclamide	2	30
Glipizide	2	30
Glyburide	1	10
Insulin	1	10
Rosiglitazone (trade name Avandia)	1	10

23 Diseases Researched for Drug: Metformin

Name	AC	CK
Diabetes Mellitus: Type 2	15	146
Diabetes: Cardiovascular Illness	5	70
Coronary Artery Disease	3	50
Cardiac Mortality	2	20
Congestive Heart Failure	1	20
Osteoporosis	2	11
Adrenal Hyperandrogenism	1	10
Breast Cancer	1	10
Breast: Mammographic Density	1	10
Cancers: All	1	10
Diabetes: Lipids/Cholesterol	1	10
Drug-Induced Nutritional Deficiencies	1	10
Heart Failure	1	10
Hyperinsulinism	1	10
Myocardial Infarction	1	10
Polycystic Ovary Syndrome	1	10
Diabetes Mellitus: Type 1	3	6
Diabetes: Cognitive Dysfunction	1	2
Hyperglycemia	1	2
Hypothyroidism	1	2
Insulin Resistance	1	2
Oxidative Stress	1	2
Colorectal Cancer	1	1

2 Adverse Pharmacological Actions Researched for Drug: Metformin

Name	AC	CK	Focus
Cardiotoxic	2	40
Endocrine Disruptor: Thyroid	1	2

20 Substances Researched for Drug: Metformin

Name	AC	CK
Berberine	4	23
Calcium	1	10
Chinese Herbal Formula: Tiangui Fang	1	10
Garlic	1	10
NAC (N-acetyl-L-cysteine)	1	10
Chinese Skullcap	1	2
Cinnamaldehyde	1	2
Cinnamon	1	2
Fenugreek	1	2
Formononetin	1	2
Grapefruit Seed Extract	1	2
Honeybush	1	2
Polyphenols	1	2
Prickly Pear Cactus	1	2
Pterocarpus marsupium	1	2
Sage	1	2
Alpha-Lipoic Acid	1	1
Catechin	1	1
Resveratrol	1	1
Silibinin	1	1

15 Pharmacological Actions Researched for Drug: Metformin

Name	AC	CK
Hypoglycemic Agents	8	56
Apoptotic	3	12
Antiproliferative	1	10
Hypolipidemic	1	10
Antioxidants	2	4
Alpha-glucosidase inhibitor	1	2
Anti-Inflammatory Agents	1	2
Gluconeogenesis Inhibitor	1	2
Interleukin-1 beta downregulation	1	2
Interleukin-6 Downregulation	1	2
NF-kappaB Inhibitor	1	2
Pancreato Protective Agents	1	2
Tumor Necrosis Factor (TNF) Alpha Inhibitor	1	2
Osteogenic	1	1
RANK Downregulation	1	1

Research Articles 27
Cumulative Knowledge Score 43
Overall Research Rating GOOD

View the Evidence:
29 Abstracts with Drug: Metformin Research

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View the Evidence: 29 Abstracts with Drug: Metformin Research

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Initiating treatment of type 2 diabetes with glibenclamide or glipizide is associated with increased risk of coronary artery disease in comparison to gliclazide or glimepiride.Dec 01, 2008

Sulfonylureas are associated with an increased risk of adverse cardiovascular events in type 2 diabetic patients.Jun 01, 2009

Berberine is a potent oral hypoglycemic agent with benefical effects on lipid metabolism, comparable in efficacy to metformin. May 01, 2008

Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.Oct 06, 2009

Garlic improves metformin therapy in type 2 diabetics. Oct 01, 2011

Glibenclamide in combination with metformin is associated with significantly higher mortality. Nov 01, 2006

Increased intake of calcium reverses vitamin B12 malabsorption induced by the anti-diabetic drug metformin. Sep 01, 2000

Metformin and sulfonylurea drugs are associated with adverse side effects such as lactic acidosis and hypoglycemia, including fatal incidences. Jan 01, 1985

N-acetylcysteine compares favorably to metformin on mammographic density in postmenopausal women.Dec 31, 2011

Patients with type 2 diabetes who use sulfonylureas or insulin have an increased risk for cancer-related mortality. Feb 01, 2006

The Chinese herbal formula "tiangui fang" may have value in the treatment of hyperandrogenism and hyperinsulinism in polycystic ovary syndrome.Aug 01, 2000

The use of glyburide and/or metformin results in increased mortality in type 2 diabetics with coronary artery disease. Feb 01, 2001

The use of rosiglitazone (Avandia) in type 2 diabetic patients is associated with an increased risk of heart failure and of some fractures, mainly in women. Jun 20, 2009

There is a higher cardiovascular mortality in Type II diabetic patients taking sulphonylurea and metformin in combination than in those taking only sulphonylurea.May 01, 2000

Type 2 diabetic patients with ischemic heart disease using metformin, alone or in combination with sulfonylureas, exhibited a significantly increased mortality.Jan 01, 1999

Aqueous extract of unfermented honeybush attenuates STZ-induced diabetes and β-cell cytotoxicity.May 31, 2014

Cinnamaldehyde and berberine have greater anti-diabetic efficacy than metformin. Nov 05, 2008

Fenugreek seed polyphenolic extract and quercetin compares favorably to metformin in improving insulin signaling, sensitivity and functioning in a rat model. Apr 01, 2009

Fucoxanthin regulates Nrf2/Keap1 signaling to alleviate myocardial hypertrophy in diabetes.May 19, 2022

Grapefruit seed extract is comparable to metformin in positively modulating blood lipid profiles and blood sugar. Oct 01, 2008

Hepatoprotective effect of Opuntia microdasys (Lehm.) Pfeiff flowers against diabetes type II induced in rats.Sep 30, 2017

Hypoglycemic, Hypolipidemic and Antioxidant Potentials of Ethanolic Stem Bark Extract of Anacardium occidentale.Jun 29, 2022

Metformin may contribute to hypothyroidism.Aug 01, 2009

Pterocarpus marsupium exhibits antihyperglycemic activity. Jun 01, 1997

Sage leaf extract may be an effective treatment for type 2 diabetes.Aug 01, 2006

Scutellaria baicalensis (skullcap) enhances the anti-diabetic activity of metformin in diabetic rats. Jan 01, 2008

The protective effect of formononetin on cognitive impairment in streptozotocin-induced diabetic mice.Sep 30, 2018

Combined treatment of human colorectal cancer cells with silibinin and metformin may induce apoptosis at a dose that does not affect HCoEpiC.Apr 13, 2015

Resveratrol, EGCG, berberine and alpha-lipoic acid may have a beneficial effect on bone health through negatively regulating RANKL.Nov 01, 2010

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Drug: Metformin

View the Evidence:
29 Abstracts with Drug: Metformin Research