Drug: Metformin

Focus Your Research

Click any topic below to filter + focus research

7 Problem Substances Researched for Drug: Metformin

Name	AC	CK
Sulfonylureas	6	70
Metformin	5	42
Glibenclamide	2	30
Glipizide	2	30
Glyburide	1	10
Insulin	1	10
Rosiglitazone (trade name Avandia)	1	10

27 Diseases Researched for Drug: Metformin

Name	AC	CK
Diabetes Mellitus: Type 2	20	172
Diabetes: Cardiovascular Illness	5	70
Coronary Artery Disease	3	50
Cardiac Mortality	2	20
Congestive Heart Failure	1	20
Osteoporosis	2	11
Adrenal Hyperandrogenism	1	10
Breast Cancer	1	10
Breast: Mammographic Density	1	10
Cancers: All	1	10
Diabetes: Lipids/Cholesterol	1	10
Drug-Induced Nutritional Deficiencies	1	10
Heart Failure	1	10
Hyperinsulinism	1	10
Myocardial Infarction	1	10
Polycystic Ovary Syndrome	1	10
Diabetes Mellitus: Type 1	3	6
Hyperglycemia	2	4
Oxidative Stress	2	4
Cardiomegaly	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Diabetes: Cognitive Dysfunction	1	2
Hypothyroidism	1	2
Insulin Resistance	1	2
Myocardial Fibrosis	1	2
Wound Healing	1	2
Colorectal Cancer	1	1

2 Adverse Pharmacological Actions Researched for Drug: Metformin

Name	AC	CK	Focus
Cardiotoxic	2	40
Endocrine Disruptor: Thyroid	1	2

26 Substances Researched for Drug: Metformin

Name	AC	CK
Berberine	4	23
Calcium	1	10
Chinese Herbal Formula: Tiangui Fang	1	10
Garlic	1	10
NAC (N-acetyl-L-cysteine)	1	10
Polyphenols	2	4
Cashew	1	2
Chinese Skullcap	1	2
Cinnamaldehyde	1	2
Cinnamon	1	2
Fenugreek	1	2
Flavonoids	1	2
Formononetin	1	2
Fucoxanthin	1	2
Grapefruit Seed Extract	1	2
Hesperidin	1	2
Honeybush	1	2
Mululuza	1	2
Prickly Pear Cactus	1	2
Pterocarpus marsupium	1	2
Sage	1	2
Seaweed: Brown	1	2
Alpha-Lipoic Acid	1	1
Catechin	1	1
Resveratrol	1	1
Silibinin	1	1

3 Therapeutic Actions Researched for Drug: Metformin

Name	AC	CK
Dietary Modification: Low Carbohydrate/Ketogenic	1	10
Exercise: HIIT	1	10
Photobiomodulation	1	2

19 Pharmacological Actions Researched for Drug: Metformin

Name	AC	CK
Hypoglycemic Agents	12	72
Hypolipidemic	3	22
Antioxidants	6	12
Apoptotic	3	12
Cardioprotective	2	12
Antiproliferative	1	10
Hepatoprotective	1	10
Anti-Inflammatory Agents	2	4
NF-kappaB Inhibitor	2	4
Tumor Necrosis Factor (TNF) Alpha Inhibitor	2	4
Alpha-glucosidase inhibitor	1	2
Gluconeogenesis Inhibitor	1	2
Heme oxygenase-1 up-regulation	1	2
Interleukin-1 beta downregulation	1	2
Interleukin-6 Downregulation	1	2
Pancreato Protective Agents	1	2
Superoxide Dismutase Up-regulation	1	2
Osteogenic	1	1
RANK Downregulation	1	1

Research Articles 35
Cumulative Knowledge Score 56
Overall Research Rating GOOD

View the Evidence:
35 Abstracts with Drug: Metformin Research

Filter by Study Type

Sort Abstracts

Limited to Members Only

By default, all articles on GreenMedInfo.com are sorted based on the content type which best reflects the data which most users are searching for. For instance, people viewing substances are generally most interested in viewing diseases that these substances have shown to have positive influences. This section is for allowing more advanced sorting methods. Currently, these advanced sorting methods are available for members only. If you are already a member, you can sign in by clicking here. If you do not currently have a user account, and would like to create one/become a member, click here to begin the singup process.

Currently Available Sorting Options

Article Published Date - Sort all displayed articles by their published date
Quick Summary Fieldsets - Sort alphabetically, rather than by Cumulative Knowledge
Cumulative Knowledge - Default sorting method. Allows you to sort descendingly

Free Sample of Member-Only Features

Although all 30,000+ articles on GreenMedInfo.com are made entirely free to view as an educational service to the public, we provide a powerful set of enhanced data comprehension and retrieval tools for subscribing members. Above you are viewing a free preview, limited to 10000 rows, of the membership feature called "Cumulative Knowledge" (learn more).

The Focus Article Feature is not enabled.

Upgrading to the Friend membership gives you access to unlimited rows of Cumulative Knowledge data.

To Participate

Click here to login
Click here to order a membership

[+]

Drug: Metformin jQuery(function ($) { $(".node-field-image").click(function () { $(".node-field-image").toggleClass("open"); }); $(".node.topic>.colfull").click(function () { $(".node.topic>.colfull").toggleClass("open"); }); })

Focus Your Research

Click any topic below to filter + focus research

View the Evidence: 35 Abstracts with Drug: Metformin Research

Limited to Members Only

Currently Available Sorting Options

Initiating treatment of type 2 diabetes with glibenclamide or glipizide is associated with increased risk of coronary artery disease in comparison to gliclazide or glimepiride.Dec 01, 2008

Sulfonylureas are associated with an increased risk of adverse cardiovascular events in type 2 diabetic patients.Jun 01, 2009

Berberine is a potent oral hypoglycemic agent with benefical effects on lipid metabolism, comparable in efficacy to metformin. May 01, 2008

Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.Oct 06, 2009

Garlic improves metformin therapy in type 2 diabetics. Oct 01, 2011

Glibenclamide in combination with metformin is associated with significantly higher mortality. Nov 01, 2006

High intensity intermittent exercise improves cardiac structure and function and reduces liver fat in patients with type 2 diabetes.Dec 31, 2015

In T2D patients treated with diet and metformin, two days of iso-energetic replacement of dietary carbohydrates by protein and fat reduced all indices of glycaemic variability by 36%-45%.Sep 30, 2020

Increased intake of calcium reverses vitamin B12 malabsorption induced by the anti-diabetic drug metformin. Sep 01, 2000

Metformin and sulfonylurea drugs are associated with adverse side effects such as lactic acidosis and hypoglycemia, including fatal incidences. Jan 01, 1985

N-acetylcysteine compares favorably to metformin on mammographic density in postmenopausal women.Dec 31, 2011

Patients with type 2 diabetes who use sulfonylureas or insulin have an increased risk for cancer-related mortality. Feb 01, 2006

The Chinese herbal formula "tiangui fang" may have value in the treatment of hyperandrogenism and hyperinsulinism in polycystic ovary syndrome.Aug 01, 2000

The use of glyburide and/or metformin results in increased mortality in type 2 diabetics with coronary artery disease. Feb 01, 2001

The use of rosiglitazone (Avandia) in type 2 diabetic patients is associated with an increased risk of heart failure and of some fractures, mainly in women. Jun 20, 2009

There is a higher cardiovascular mortality in Type II diabetic patients taking sulphonylurea and metformin in combination than in those taking only sulphonylurea.May 01, 2000

Type 2 diabetic patients with ischemic heart disease using metformin, alone or in combination with sulfonylureas, exhibited a significantly increased mortality.Jan 01, 1999

Aqueous extract of unfermented honeybush attenuates STZ-induced diabetes and β-cell cytotoxicity.May 31, 2014

Cinnamaldehyde and berberine have greater anti-diabetic efficacy than metformin. Nov 05, 2008

Combination of metformin and hesperidin mitigates cyclophosphamide-induced hepatotoxicity.Mar 31, 2023

Fenugreek seed polyphenolic extract and quercetin compares favorably to metformin in improving insulin signaling, sensitivity and functioning in a rat model. Apr 01, 2009

Fucoxanthin regulates Nrf2/Keap1 signaling to alleviate myocardial hypertrophy in diabetes.May 19, 2022

Grapefruit seed extract is comparable to metformin in positively modulating blood lipid profiles and blood sugar. Oct 01, 2008

Hepatoprotective effect of Opuntia microdasys (Lehm.) Pfeiff flowers against diabetes type II induced in rats.Sep 30, 2017

Hypoglycemic, Hypolipidemic and Antioxidant Potentials of Ethanolic Stem Bark Extract of Anacardium occidentale.Jun 29, 2022

Metformin may contribute to hypothyroidism.Aug 01, 2009

Pterocarpus marsupium exhibits antihyperglycemic activity. Jun 01, 1997

Sage leaf extract may be an effective treatment for type 2 diabetes.Aug 01, 2006

Sargassum fusiforme polysaccharide is a potential auxiliary substance for metformin in the management of diabetes.Mar 06, 2022

Scutellaria baicalensis (skullcap) enhances the anti-diabetic activity of metformin in diabetic rats. Jan 01, 2008

The effect of combined photobiomodulation and metformin on open skin wound healing in a non-genetic model of type II diabetes.Mar 31, 2017

The protective effect of formononetin on cognitive impairment in streptozotocin-induced diabetic mice.Sep 30, 2018

Vernonia amygdalina possesses antihyperglycemic effect.Jan 26, 2011

Combined treatment of human colorectal cancer cells with silibinin and metformin may induce apoptosis at a dose that does not affect HCoEpiC.Apr 13, 2015

Resveratrol, EGCG, berberine and alpha-lipoic acid may have a beneficial effect on bone health through negatively regulating RANKL.Nov 01, 2010

Print Options

Drug: Metformin

View the Evidence:
35 Abstracts with Drug: Metformin Research