Drug: Paclitaxel

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17 Diseases Researched for Drug: Paclitaxel

Name	AC	CK	Focus
Chemotherapy-Induced Toxicity: Cisplatin	1	10
Chemotherapy-Induced Toxicity: Paclitaxel	1	10
Chemotherapy-Induced Toxicity: Peripheral Neuropathy	1	10
Esophageal Cancer	1	10
Neuropathic Pain	1	10
Breast Cancer	3	5
Chemotherapy	2	3
Lung Cancer	2	3
Breast Cancer: Lung Metastasis	1	2
Liver Cancer	1	2
Melanoma	1	2
Ovarian Cancer	1	2
Cancers: Multi-Drug Resistant	1	1
Gastric Cancer	1	1
Multiple Myeloma	1	1
Non-Hodgkin Lymphoma	1	1
Retinoblastoma	1	1

1 Problematic Actions Researched for Drug: Paclitaxel

Name	AC	CK	Focus
Chemotherapy	1	10

11 Substances Researched for Drug: Paclitaxel

Name	AC	CK	Focus
Acetyl-l-carnitine	1	10
Curcumin	3	5
Collagen	1	2
Diosgenin	1	2
EGCG (Epigallocatechin gallate)	1	2
Fenugreek	1	2
Resveratrol	2	2
Whey	1	2
Cannabinoids	1	1
Feverfew	1	1
Tabebuia	1	1

10 Pharmacological Actions Researched for Drug: Paclitaxel

Name	AC	CK	Focus
Apoptotic	7	9
Chemosensitizer	6	8
Antineoplastic Agents	3	5
Antiproliferative	3	4
Cell cycle arrest	3	4
NF-kappaB Inhibitor	2	3
Cyclooxygenase 2 Inhibitors	1	2
Enzyme Inhibitors	1	2
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	2
Tumor Suppressor Protein p53 Upregulation	1	1

Research Articles 13
Cumulative Knowledge Score 21
Overall Research Rating GOOD

View the Evidence:
13 Abstracts with Drug: Paclitaxel Research

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Bi-weekly administration of paclitaxel and cisplatin in patients with advanced esophageal cancer results in amedian survival for all patients of 9 months.Mar 04, 2002

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Pubmed Data : Br J Cancer. 2002 Mar 4;86(5):669-73. PMID: 11875723

Article Published Date : Mar 04, 2002

Study Type : Human Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Esophageal Cancer

Additional Keywords : Drug: Cisplatin, Drug: Paclitaxel

Anti Therapeutic Actions : Chemotherapy

[+]

Prophylactic acetyl-L-carnitine treatment against paclitaxel-evoked pain may be related to a protective effect on C-fiber mitochondria.Mar 01, 2008

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Pubmed Data : Exp Neurol. 2008 Mar;210(1):229-37. Epub 2007 Nov 17. PMID: 18078936

Article Published Date : Mar 01, 2008

Study Type : Human Study

Additional Links

Substances : Acetyl-l-carnitine

Diseases : Chemotherapy-Induced Toxicity: Paclitaxel, Chemotherapy-Induced Toxicity: Peripheral Neuropathy, Neuropathic Pain

Additional Keywords : Drug: Paclitaxel

[+]

Curcumin enhances oral bioavailability and anti-tumor therapeutic efficacy of paclitaxel upon administration in nanoemulsion formulation.Jan 01, 2010

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Pubmed Data : PLoS One. 2010;5(10):e13264. Epub 2010 Oct 11. PMID: 20845461

Article Published Date : Jan 01, 2010

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Chemotherapy, Ovarian Cancer

Pharmacological Actions : Enzyme Inhibitors

Additional Keywords : Drug: Paclitaxel, Drug Synergy

[+]

Curcumin works synergistically with paclitaxel to inhibit breast cancer cell metastasis to the lung in a mouse model. Oct 15, 2005

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Pubmed Data : Clin Cancer Res. 2005 Oct 15;11(20):7490-8. PMID: 16243823

Article Published Date : Oct 15, 2005

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Breast Cancer, Breast Cancer: Lung Metastasis, Lung Cancer

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, NF-kappaB Inhibitor

Additional Keywords : Drug: Paclitaxel, Drug-Plant-Vitamin Synergies

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Diosgenin, a compound isolated from fenugreek, has chemosensitizing activity against human liver cancer cells. Jan 04, 2010

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Pubmed Data : Cancer Lett. 2010 Jan 4. Epub 2010 Jan 4. PMID: 20053498

Article Published Date : Jan 04, 2010

Study Type : Animal Study

Additional Links

Substances : Diosgenin, Fenugreek

Diseases : Liver Cancer

Pharmacological Actions : Chemosensitizer

Additional Keywords : Drug: Doxorubicin, Drug: Paclitaxel, Drug-Plant-Vitamin Synergies

[+]

EGCG sensitizes breast cancer cells to paclitaxel in a mouse model of breast carcinoma.Jan 15, 2010

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Pubmed Data : Breast Cancer Res. 2010 Jan 15;12(1):R8. Epub 2010 Jan 15. PMID: 20078855

Article Published Date : Jan 15, 2010

Study Type : Animal Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Breast Cancer

Pharmacological Actions : Chemosensitizer

Additional Keywords : Drug: Paclitaxel

[+]

Whey and collagen hydrolysate protein inhibit melanoma proliferation in mice treated with paclitaxel.Oct 01, 2009

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Pubmed Data : J Cutan Pathol. 2009 Oct;36(10):1053-62. Epub 2009 Jan 27. PMID: 19187112

Article Published Date : Oct 01, 2009

Study Type : Animal Study

Additional Links

Substances : Collagen, Whey

Diseases : Melanoma

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Drug: Paclitaxel, Drug-Plant-Vitamin Synergies

[+]

Cannabinoids work synergistically with paclitaxel in gastric cancer cell lines.Jul 01, 2009

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Pubmed Data : J Surg Res. 2009 Jul;155(1):40-7. Epub 2008 Aug 9. PMID: 19394652

Article Published Date : Jul 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Cannabinoids

Diseases : Gastric Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemosensitizer

Additional Keywords : Drug: Paclitaxel, Drug Synergy

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Curcumin works synergistically with paclitaxel to overcome multidrug resistance in tumor cells. May 01, 2009

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Pubmed Data : Mol Pharm. 2009 May-Jun;6(3):928-39. PMID: 19278222

Article Published Date : May 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cancers: Multi-Drug Resistant, Chemotherapy

Pharmacological Actions : Antineoplastic Agents, Apoptotic, NF-kappaB Inhibitor

Additional Keywords : Drug: Paclitaxel, Drug-Plant-Vitamin Synergies, Drug Synergy

[+]

Feverfew contains the compound parthenolide which exhibits microtubule-interfering activity in human breast cancer cells. Oct 15, 2004

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Pubmed Data : Chem Biol Interact. 2004 Oct 15;149(2-3):165-73. PMID: 15501437

Article Published Date : Oct 15, 2004

Study Type : In Vitro Study

Additional Links

Substances : Feverfew

Diseases : Breast Cancer

Additional Keywords : Drug: Paclitaxel, Drug-Plant-Vitamin Synergies, Plant Extracts

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Paclitaxel and beta-lapachone (a compound within Tabebuia) synergistically induce programmed cell death in human retinoblastoma cells.Feb 01, 2010

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Pubmed Data : J Cell Physiol. 2010 Feb;222(2):433-43. PMID: 19918798

Article Published Date : Feb 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Tabebuia

Diseases : Retinoblastoma

Pharmacological Actions : Apoptotic, Chemosensitizer, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Drug: Paclitaxel, Drug Synergy

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Resveratrol combines favorably with paclitaxel to induce cell death in lung cancer cells. Sep 01, 2003

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Pubmed Data : Anticancer Res. 2003 Sep-Oct;23(5A):4039-46. PMID: 14666716

Article Published Date : Sep 01, 2003

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Drug: Paclitaxel, Drug-Plant-Vitamin Synergies, Stilbenes

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Resveratrol increase the sensitivy of non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced programmed cell death. Jan 01, 2004

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Pubmed Data : Mol Cancer Ther. 2004 Jan;3(1):71-84. PMID: 14749477

Article Published Date : Jan 01, 2004

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Multiple Myeloma, Non-Hodgkin Lymphoma

Pharmacological Actions : Apoptotic, Cell cycle arrest, Chemosensitizer

Additional Keywords : Drug: Paclitaxel, Drug-Plant-Vitamin Synergies, Stilbenes

Research Articles 13
Cumulative Knowledge Score 21
Overall Research Rating GOOD

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