Drug Synergy

Name	AC	CK
Simvastatin	2	13
Statin Drugs	2	13
Atorvastatin	1	3
Fenofibrates	1	3
Gemfibrozil	1	3
Arsenic	1	2
Donepezil (trade name Aricept)	1	2
Fluoride	1	2
Fructose	1	2
Insulin	1	2
Memantine	1	2
Sodium Selenate	1	2
Sodium Selenite	1	2
Cipro	1	1
Cisplatin	1	1
Doxorubicin	1	1
Glyphosate formulations	1	1
Roundup (herbicide)	1	1

Name	AC	CK
Breast Cancer	20	56
Cancers: Drug Resistant	21	45
Diabetes Mellitus: Type 2	5	32
Lung Cancer	8	29
Pancreatic Cancer	11	22
Dyslipidemias	2	20
Chemotherapy-Induced Toxicity: Cisplatin	4	18
Cancers: Multi-Drug Resistant	9	17
Statin-Induced Pathologies	3	16
Oxidative Stress	10	15
Liver Cancer	9	14
Cervical Cancer	4	13
Osteosarcoma	4	13
Diabetes: Cardiovascular Illness	2	12
Leukemia: Chronic myelogenous leukemia (CML)	3	12
Upper Respiratory Infections	2	11
A1C	1	10
Atrial Fibrillation	1	10
Atrial Fibrillation: Cardioconversion	1	10
Bone Fractures	1	10
Breast Cancer: Metastatic	1	10
Cervical Dysplasia	1	10
Childhood Infections	1	10
Coronary Artery Disease	1	10
Diabetes: Glycation/A1C	1	10
Diabetes: Lipids/Cholesterol	1	10
Dietary Fatty Acid Imbalance: Omega3/Omega6 Ratio	1	10
Drug-Induced Nutrient Depletion: Statin Drugs	1	10
Fatty Liver	1	10
Hyperlipidemia	1	10
Omega-3 Fatty Acid Deficiency	1	10
Osteoporosis	1	10
Pneumonia	1	10
Tachycardia	1	10
Torsades de Pointes	1	10
Triglycerides: Elevated	1	10
Colon Cancer	8	9
Ovarian Cancer	4	9
Colorectal Cancer	5	8
Carcinoma: Non-Small-Cell Lung	3	7
Gastric Cancer	3	7
Prostate Cancer	6	7
Chemotherapy	4	6
Female	1	5
MRSA	5	5
Bladder Cancer	2	4
Cancers: All	4	4
Candida Infection	4	4
DNA damage	3	4
Endothelial Dysfunction	2	4
Leukemia	3	4
Morphine Tolerance/Dependence	2	4
Neuroblastoma	2	4
Cancer Stem Cells	3	3
Chemotherapy-Induced Toxicity	2	3
Insulin Resistance	2	3
Liver Fibrosis	2	3
Multi-Organ Failure	1	3
Multiple Myeloma	3	3
Myocardial Infarction	2	3
Promyelocytic leukemia	3	3
Rhabdomyolysis	1	3
Acetaminophen (Tylenol) Toxicity	1	2
Aging	1	2
Aging: Brain	1	2
Alzheimer's Disease	1	2
Amyotrophic Lateral Sclerosis	1	2
Atherosclerosis	1	2
Bacterial Infections: Resistance/Biofilm Formation	2	2
Birth Defects	1	2
Brain Damage	1	2
Cerebral Ischemia	1	2
Chemically-Induced Liver Damage	1	2
Chemotherapy Induced Myelotoxicity	1	2
Chemotherapy-Induced Toxicity: Mitomycin-C	1	2
Diabetic Complications	1	2
Drug-Induced Toxicity: Epilepsy Drugs	1	2
Endometrial Cancer	1	2
Epilepsy	1	2
Erectile Dysfunction	1	2
Fibrosarcoma	1	2
Glioma	1	2
Head and Neck Cancer	1	2
Heart Failure	1	2
Hepatoma	1	2
Hypercholesterolemia	1	2
Hypertension	1	2
Immune Disorders: Low Immune Function	1	2
Inflammation	2	2
Influenza A	1	2
Influenza B	1	2
Kidney Failure: Chronic	1	2
Leptin Resistance	1	2
Liver Disease	1	2
Motor Neuron Disease	1	2
Neurodegenerative Diseases	1	2
Obesity	1	2
Organ Transplantation: Heart	1	2
Pain	1	2
Peripheral Neuropathies	1	2
Prenatal Chemical Exposures	1	2
Skin Cancer	1	2
Weight Problems	1	2
Acute Myeloid Leukemia	1	1
Acute lymphoblastic leukemia (ALL)	1	1
Cancer Metastasis	1	1
Candidiasis	1	1
Chronic Myeloid Leukemia	1	1
Colon Cancer Stem Cells	1	1
Coronavirus Infection	1	1
Diabetes Insipidus	1	1
Diabetes Mellitus: Type 1	1	1
Drug Toxicity: Methotrexate	1	1
Esophageal Cancer	1	1
Fungal Infection	1	1
Fungal Infections: Biofilm Formation/Resistance	1	1
Gastrointestinal polyps	1	1
Glioblastoma Multiforme	1	1
Hepatitis C	1	1
Infection: Antibiotic Resistant	1	1
Insulin-like Growth Factor (IGF): Elevated	1	1
Klebsiella Infections	1	1
Laryngeal Cancer	1	1
Lipopolysaccharide-Induced Toxicity	1	1
Lymphoma	1	1
Malaria	1	1
Mitochondrial Dysfunction	1	1
Muscle Atrophy	1	1
Osteoarthritis: Knee	1	1
Pseudomonas aeruginosa	1	1
Retinal Diseases	1	1
Retinoblastoma	1	1
Squamous cell carcinoma	1	1
Staphylococcal Infections	1	1
Staphylococcus epidermidis	1	1
Stem Cell Transplant	1	1
Urinary Tract Infections	1	1

Name	AC	CK
Myotoxicity	1	3
Endocrine disruption: Leptin resistance	1	2
Neurotoxic	1	2
Teratogenic	1	2

Name	AC	CK
Curcumin	69	108
Soy	3	22
Probiotics	2	20
Isoflavones	3	17
Arginine	4	16
Resveratrol	11	15
Vitamin D	4	13
Garlic	3	12
Polyphenols	3	12
Vitamin K2	3	12
Milk Thistle	3	11
Silibinin	3	11
Turmeric	2	11
Caffeine	1	10
EGCG (Epigallocatechin gallate)	1	10
Magnesium	1	10
Magnesium Sulfate	1	10
Sesame Seed Oil	1	10
Vitamin C: Intravenous	1	10
Sulforaphane	3	8
Genistein	6	7
Catechin	4	6
Green Tea	3	5
Huaier (Trametes robiniophila murr)	1	5
Red Clover	1	5
Vitamin C	4	5
Deguelin	2	3
Ellagic Acid	2	3
NAC (N-acetyl-L-cysteine)	2	3
Quercetin	3	3
Stilbenes	2	3
Tea	2	3
Allicin	2	2
Anandamide	1	2
Berberine	2	2
Beta-glucan	1	2
Black Tea	1	2
Broccoli	1	2
Cucumber	1	2
Echinacea	1	2
Embelia ribes	1	2
Ginger	1	2
Glycoaminoglycans	1	2
Insulin-like Growth Factor (IGF-1)	1	2
Isoquercitrin	1	2
Kava Kava	1	2
Lysine	1	2
Mulberry	1	2
Pelargonium graveolens	2	2
Piperidines	1	2
Proline	1	2
Pumpkin	1	2
Shilajit	1	2
Soy Protein	1	2
Sprouts	1	2
Tocotrienol: Delta	2	2
Andrographis	1	1
Ashwagandha	1	1
Bacopa	1	1
Baicalein	1	1
Bay leaf	1	1
Cannabinoids	1	1
Cardamonin	1	1
Cayenne	1	1
Cinnamon	1	1
Copper	1	1
Cordyceps Militaris	1	1
DHA (Docosahexaenoic Acid)	1	1
Daidzein	1	1
Flavonoids	1	1
Ginsenosides	1	1
Glycyrrhizin	1	1
Holy Basil	1	1
Honokiol	1	1
Indole-3-Carbinol	1	1
Kaempferol	1	1
Licorice	1	1
Mango Seed	1	1
Manuka Honey	1	1
Melatonin	1	1
Myricetin	1	1
Nobiletin	1	1
Olive leaf extract	1	1
Phellinus Linteus	1	1
Pomegranate	1	1
Protandim	1	1
Pterostilbene	1	1
Puerarin	1	1
Red Sage	1	1
Rosemaric Acid	1	1
Tabebuia	1	1
Tannic Acid	1	1
Thymoquinone	1	1
Tocotrienol: Gamma	1	1
Vitamin E	1	1
Vitamin E: Gamma-tocotrienol	1	1
Vitamin K	1	1
Walnut	1	1

Name	AC	CK	Focus
Hyperbaric Treatment	1	10

Name	AC	CK
Apoptotic	59	89
Chemosensitizer	48	82
Antineoplastic Agents	36	69
Antiproliferative	43	65
Antioxidants	19	44
Cell cycle arrest	19	31
NF-kappaB Inhibitor	22	29
Hypoglycemic Agents	6	27
Anti-Bacterial Agents	7	16
Anti-metastatic	3	13
Radiosensitizer	3	13
Anticholesteremic Agents	2	12
Caspase-3 Activation	3	11
Hypolipidemic	1	10
Nitric Oxide Inhibitor	1	10
Tumor Suppressor Protein p53 Upregulation	4	9
Neuroprotective Agents	4	8
Anticarcinogenic Agents	5	7
Cyclooxygenase 2 Inhibitors	6	7
Antifungal Agents	6	6
Chemotherapeutic	2	6
Hepatoprotective	3	6
Anti-Inflammatory Agents	4	5
Anti-Tumor	1	5
Chemopreventive	3	5
HER-2 oncoprotein down-regulation	1	5
Analgesics	2	4
Anti-Angiogenic	2	4
Antiviral Agents	3	4
Drug synergy	3	4
Nitric Oxide Enhancer	2	4
Renoprotective	2	4
Vascular Endothelial Growth Factor A Inhibitor	2	4
Vasodilator Agents	2	4
Calcium Channel Blockers	1	3
Enzyme Inhibitors	2	3
Matrix metalloproteinase-2 (MMP-2) inhibitor	2	3
Superoxide Dismutase Up-regulation	2	3
Tumor Necrosis Factor (TNF) Alpha Inhibitor	3	3
Bcl-2 protein down-regulation	2	2
Cardioprotective	1	2
Cyclooxygenase 1 Inhibitor	2	2
Immunomodulatory	1	2
Immunosuppressive Agents	1	2
Anti-Androgen	1	1
Anti-Proliferative	1	1
Antimalarials	1	1
Caspase-9 Activation	1	1
Cell Differentiation Inducer	1	1
Cyclooxygenase Inhibitors	1	1
Epidermal growth factor receptor (EGFR) inhibitor	1	1
Heat Shock Protein Down-Regulation	1	1
Immunostimulatory	1	1
Insulin-Like Growth Factor Inhibition/Downregulation	1	1
MicroRNA modulator	1	1
Prostaglandin PGE2 downregulation	1	1
Proteasome Inhibitors	1	1
Protein Kinase Inhibitors	1	1
Quorum Sensing Inhibition	1	1
Survival protein down-regulation	1	1
TRAIL sensitizer	1	1
apoptosis	1	1

Click here to read the entire abstract

Pubmed Data : Oncol Rep. 2009 Nov;22(5):1045-50. PMID: 19787219

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Food Chem Toxicol. 2007 Jul;45(7):1293-300. Epub 2007 Jan 26. PMID: 17353074

Article Published Date : Jul 01, 2007

Study Type : Animal Study

Additional Links

Substances : Kava Kava

Additional Keywords : Drug Synergy, Plant Extracts

[+]

Selective activity of deguelin identifies therapeutic targets for androgen receptor-positive breast cancerDec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Chemother Pharmacol. 2006 Feb;57(3):376-88. Epub 2005 Jul 14. PMID: 16021489

Article Published Date : Feb 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cancers: Multi-Drug Resistant

Additional Keywords : Drug Synergy

[+]

Cytotoxicity of juglone and thymoquinone against pancreatic cancer cells.Aug 24, 2020

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Pubmed Data : Chem Biol Interact. 2020 Aug 25 ;327:109142. Epub 2020 Jun 28. PMID: 32610056

Article Published Date : Aug 24, 2020

Study Type : In Vitro Study

Additional Links

Substances : Thymoquinone, Walnut

Diseases : Pancreatic Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic

Additional Keywords : Drug Synergy

[+]

Deguelin potentiates apoptotic activity of an EGFR tyrosine kinase inhibitor (AG1478) in PIK3CA-mutated head and neck squamous cell carcinoma.Jan 25, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Med Hypotheses. 2011 Feb;76(2):291-2. Epub 2010 Nov 3. PMID: 21051155

Article Published Date : Feb 01, 2011

Study Type : Review

Additional Links

Substances : Resveratrol

Diseases : Diabetes Mellitus: Type 1, Diabetes Mellitus: Type 2, Muscle Atrophy

Additional Keywords : Drug: Bortezomib, Drug Synergy

[+]

Resveratrol may have value as a potential adjunctive treatment for late-stage hormone refractory prostate cancer.Nov 15, 2010

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Pubmed Data : Hum Mol Genet. 2010 Nov 15;19(22):4319-29. Epub 2010 Aug 20. PMID: 20729295

Article Published Date : Nov 15, 2010

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Prostate Cancer

Pharmacological Actions : Anti-Androgen, Antiproliferative , Cell cycle arrest, Epidermal growth factor receptor (EGFR) inhibitor

Additional Keywords : Drug Synergy, Stilbenes

[+]

Resveratrol protects human retinal pigment epithelial cells from acrolein-induced damage.Jun 01, 2010

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Pubmed Data : J Ocul Pharmacol Ther. 2010 Jun;26(3):231-6. PMID: 20565308

The natural Nuclear factor-kappaB inhibitor curcumin may help to overcome drug resistance in human pancreatic cancer. Sep 01, 2006

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Pubmed Data : Mol Cancer Ther. 2006 Sep;5(9):2251-60. PMID: 16985059

Article Published Date : Sep 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cancers: Drug Resistant, Pancreatic Cancer

Pharmacological Actions : Apoptotic, NF-kappaB Inhibitor

Additional Keywords : Drug Synergy

[+]

The vegetable compound indole-3-carbinol as a dietary supplement may benefit cancer prevention and improve adenovirus oncolytic therapies.Aug 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

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View the Evidence: 174 Abstracts with Drug Synergy Research

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"Lipid-lowering drugs and essential omega-6 and omega-3 fatty acids in patients with coronary heart disease."Jan 31, 2005

"Sesame oil exhibits synergistic effect with anti-diabetic medication in patients with type 2 diabetes mellitus."Jun 01, 2011

Caffeine potentiates chemotherapy for metastatic osteosarcoma.Sep 01, 2009

Curcumin acts as an adjuvant to imatinib in decreasing the NO levels and may help in the treatment of CML patients.Aug 15, 2011

Garlic improves metformin therapy in type 2 diabetics. Oct 01, 2011

High dietary intake of soy isoflavones was associated with lower risk of recurrence among post-menopausal patients with breast cancer positive for estrogen and progesterone receptor and those who were receiving anastrozole (Arimidex) as endocrine therapy.Feb 01, 2010

High dose magnesium converts ibutilide into a safer and more effective agent.Sep 01, 2010

High dose vitamin D3 prevents recurrence of pneumonia in children treated with antibiotics.Oct 01, 2010

Hyperbaric oxygen therapy may be an appropriate therapeutic regimen for the treatment of patients with osteosarcoma.Nov 01, 2009

Intravenous vitamin C administration improves quality of life in breast cancer patients during chemo-/radiotherapy and aftercare.Nov 01, 2011

L-Arginine enhances the triglyceride-lowering effect of simvastatin in patients with elevated plasma triglycerides.May 01, 2009

Oral curcumin is safe and feasible in patients with pancreatic cancer.Sep 22, 2010

Probiotic use concomitantly with specific anti-infective agents provides more reliable cytological diagnostics, reduces the number of false positive and false negative findings on cervical malignancy and normalizes vaginal microflora in higher percentage Nov 01, 2011

Probiotics work synergistically with cholesterol lowering drugs in the treatment of atherogenic dyslipidemia associated wtih non-alcoholic fatty liver disease.Jan 01, 2011

Tea polyphenol has potential to be a therapeutic adjuvant against human metastatic breast cancer.Feb 01, 2012

These results suggest that combined administration of black soybean with fenofibrate enhances the antihyperlipidemic action of fenofibrate.Jun 01, 2015

vitamin Vitamin (2) works synergistically with alendronate on improving both osteocalcin carboxylation and BMD of femoral neck in postmenopausal women with osteoporosis.Jan 01, 2008

Huaier may be a potential drug for the treatment of cancers caused by aberrant mTOR signaling.Mar 31, 2016

Irilone from red clover potentiates progesterone signaling.Jan 28, 2018

This study demonstrates that sulforaphane targets multiple signaling pathways to suppress ovarian cancer in vitro and in vivo.Nov 01, 2018

A possible increased risk of rhabdomyolysis during concomitant use of simvastatin and gemfibrozil has been reported. Dec 01, 1996

Atorvastatin induced multiple organ failure has been reported.May 01, 2010

A combination of curcumin and green tea catechins prevents dimethylhydrazine-induced colon carcinogenesis.Jan 01, 2010

A mixture containing ascorbic acid, lysine, proline and green tea extract inhibits breast cancer.Aug 01, 2009

Anandamide can induce apoptotis and DNA fragmentation in human neuronal and immune cells through increasing intracellular calcium, mitochondrial uncoupling and cytochrome c release.Oct 12, 2000

Arginine may work synergistically with statin drugs to prevent atherosclerosis development. Sep 01, 2005

Beta-glucan and mulberry have synergistic effects on metabolic disorders.Oct 12, 2017

Cucumis sativus and Cucurbita maxima extract attenuate diabetes-induced hepatic and pancreatic injury in a rat model.Jul 31, 2020

Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo.Sep 13, 2010

Curcumin enhances adriamycin-induced human liver-derived hepatoma G2 cell death.Jun 14, 2011

Curcumin enhances oral bioavailability and anti-tumor therapeutic efficacy of paclitaxel upon administration in nanoemulsion formulation.Jan 01, 2010

Curcumin enhances the effect of cisplatin in suppression of head and neck squamous cell carcinoma. Oct 01, 2010

Curcumin exhibits inhibitory effects liver fibrosis associated with injury. Jul 01, 2003

Curcumin has a novel synergistic effect with the drug cyclosporine as an immunosuppressive. Jun 01, 2003

Curcumin has a synergistic effect with cisplatin against fibrosarcoma.Mar 01, 1999

Curcumin has anticancer, chemosensitization and radiosensitization effects in prostate cancer.Mar 01, 2007

Curcumin inhibits endometrial cancer and works synergistically with the aromatase inhibitor letrozole. Oct 01, 2009

Curcumin may protect the aging brain from oxidative stress.Aug 01, 2010

Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer.Dec 01, 2009

Curcumin potentiates the antitumor effects of gemcitabine in an animal model of human bladder cancer through suppression of proliferative and angiogenic biomarkers.Jan 15, 2010

Curcumin protects against oxidative insult induced by pentylenetetrazol in epileptic rats.May 01, 2010

Curcumin protects rats against acetaminophen-induced hepatorenal damages and shows synergistic activity with N-acetyl cysteine.Feb 25, 2010

Curcumin reduced the side effects of mitomycin C in the treatment of breast cancer.Nov 01, 2009

Curcumin works synergistically with erythropoietin to stimulate liver regeneration.May 01, 2008

Curcumin works synergistically with oxaliplatin to inhibit colorectal cancer.May 15, 2002

Curcumin works synergistically with the drug candesartan to reduce ischemic brain damage in rats.Aug 17, 2010

Donepezil markedly potentiates memantine neurotoxicity.Feb 01, 2008

Echinacea has an immune-stimulating effect individually and synergistically with the drug agent levamisole.Aug 24, 2010

Embelin and curcumin have a beneficial effect against oxidative tissue damage during chemically-induced hepatocarinogenesis in rats.Mar 01, 2006

Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding.Nov 01, 2008

Ginger (Zingiber officinale Roscoe) elicits antinociceptive properties and potentiates morphine-induced analgesia in the rat radiant heat tail-flick test.Nov 30, 2010

Glycosaminoglycans boost insulin-like growth factor-I-promoted neuroprotection, indicating their potential value in motor neuron disease and peripheral neuropathies.Jan 01, 1999

Green tea catechins augment the antitumor activity of doxorubicin in an in vivo mouse model for chemoresistant liver cancer.Jul 01, 2010

Isoquercetin inhibit influenza A and B viruses. Nov 01, 2010

L-arginine may reduce hypercholesterolemia-induced endothelial dysfunction.Aug 30, 2005

L-arginine prevents endothelial dysfunction in rats with chronic renal failure.Mar 01, 2007

Low levels of selenium, fluoride and arsenic are toxic to rat embryos.Mar 30, 1999

Resveratrol enhances the anti-tumor effect of immunotherapy in a neuroblastoma model. Feb 22, 2011

Resveratrol may prevent cardiac dysfunction in diabetics. Dec 01, 2010

Resveratrol works synergistically with ellagic acid, grape seed extract and other phytochemicals to inhibit skin cancer promotion. Feb 01, 2010

Resveratrol works synergistically with the drug vardenafil in a diabetic animal model of erectile dysfunction.Jan 26, 2011

Safety Study: Kava does not produce or aggravte liver injury.Jul 01, 2007

Selective activity of deguelin identifies therapeutic targets for androgen receptor-positive breast cancerDec 31, 2015

Shilajit prevents the development of tolerance to morphine in mice. Jun 17, 2005

Soy and tea bioactive components may be used to inhibit the progression of estrogen-dependent breast cancer.Jan 01, 2004

Soy phytochemicals synergistically enhance the preventive effect of tamoxifen on the growth of estrogen-dependent human breast carcinoma in mice.Jun 01, 2007

Sulforaphane enhances the anticancer activity of a chemo-agent against pancreatic cancer. Aug 29, 2011

Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer.Aug 01, 2010

Vitamin K2 works synergistically with acyclic retinoid to suppress growth in human hepatocellular carcinoma cells.Mar 01, 2007

"Curcumin enhances the anticancer effects of trichostatin a in breast cancer cells."Jan 30, 2012

"Honokiol in combination with radiation targets notch signaling to inhibit colon cancer stem cells."Apr 01, 2012

"Quercetin induces oxidative stress and potentiates the apoptotic action of 2-methoxyestradiol in human hepatoma cells."Jan 01, 2009

Drug Synergy

View the Evidence:
174 Abstracts with Drug Synergy Research