Drug: Tamoxifen

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9 Problem Substances Researched for Drug: Tamoxifen
NameACCKFocus
Tamoxifen37283Locked
Arimidex340Locked
Aromatase Inhibitor Drugs330Locked
17beta-estradiol110Locked
Letrozole (trade name Femera)110Locked
Raloxifene110Locked
Aflatoxin11Locked
Paracetamol11Locked
Vinyl chloride11Locked
42 Diseases Researched for Drug: Tamoxifen
NameACCKFocus
Breast Cancer28178Locked
Endometrial Cancer16117Locked
Drug-Induced Toxicity 8102Locked
Endometrial Neoplasms431Locked
Fatty Liver431Locked
Memory Disorders: Drug-Induced230Locked
Cataract120Locked
Cognitive Decline/Dysfunction120Locked
Gastric Cancer220Locked
Osteoporosis220Locked
Chemically-Induced Liver Damage313Locked
Arthralgia110Locked
Bone Fractures110Locked
Colorectal Cancer110Locked
Coronary Artery Disease110Locked
Estrogen Dominance110Locked
Estrogen Dysregulation: 2/4/16 hydroxyestrone ratios110Locked
Gynecomastia110Locked
Hot Flash110Locked
Leukemia: Acute myelogenous leukemia (AML) 110Locked
Musculoskeletal Abnormalities110Locked
Musculoskeletal Complaints110Locked
Pain: Musculoskeletal110Locked
Rheumatic Diseases110Locked
Sexual Dysfunction110Locked
Stroke110Locked
DNA damage34Locked
Cancers: Drug Resistant33Locked
Aging12Locked
Arsenic Poisoning12Locked
Bladder Cancer12Locked
Bone Diseases12Locked
Cervical Cancer12Locked
Chemotherapy-Induced Toxicity: Tamoxifen12Locked
Liver Cancer12Locked
Oxidative Stress12Locked
Vaginal Cancer12Locked
Cancer Metastasis11Locked
Chemotherapy11Locked
Chemotherapy-Induced Toxicity11Locked
Thyroid Cancer11Locked
Uterine Cancer 11Locked
1 Problematic Actions Researched for Drug: Tamoxifen
NameACCKFocus
Chemotherapy110Locked
12 Adverse Pharmacological Actions Researched for Drug: Tamoxifen
NameACCKFocus
Carcinogenic17111Locked
Hepatotoxic330Locked
Neurotoxic230Locked
Genotoxic617Locked
Mutagenic413Locked
Estrogen Agonist211Locked
Estrogenic211Locked
Carcinogen110Locked
Cardiotoxic110Locked
Endocrine Disruptor12Locked
Oxidant12Locked
Proliferative11Locked
20 Substances Researched for Drug: Tamoxifen
NameACCKFocus
Catechin 312Locked
Alcohol 110Locked
Coffee110Locked
Tea110Locked
Vegetables: All 110Locked
Curcumin23Locked
Genistein23Locked
Flaxseed12Locked
Formononetin12Locked
Grape Seed Extract12Locked
Nigella sativa (aka Black Seed)12Locked
Red Sage12Locked
Soy12Locked
Apigenin11Locked
EPA (Eicosapentaenoic Acid)11Locked
Flavonoids11Locked
Luteolin11Locked
Pterostilbene11Locked
Quercetin11Locked
Urine11Locked
17 Pharmacological Actions Researched for Drug: Tamoxifen
NameACCKFocus
Anticarcinogenic Agents211Locked
Antioxidants211Locked
Antiproliferative 711Locked
Drug synergy211Locked
Apoptotic46Locked
Chemosensitizer23Locked
Cell cycle arrest12Locked
Hepatoprotective12Locked
Telomerase Upregulation12Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor12Locked
Anti-Angiogenic11Locked
Antineoplastic Agents11Locked
Epidermal growth factor receptor (EGFR) inhibitor11Locked
Estrogen Receptor Modulators11Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor11Locked
NF-kappaB Inhibitor11Locked
Vascular Endothelial Growth Factor A Inhibitor11Locked

View the Evidence:
60 Abstracts with Drug: Tamoxifen Research

[+]

Five or more years of tamoxifen use increases risk of cataracts in breast cancer patients.Mar 01, 2000

Pubmed Data : Breast Cancer Res Treat. 2000 Mar;60(2):167-72. PMID: 10845279
Article Published Date : Mar 01, 2000
Study Type : Meta Analysis
Additional Links
Diseases : Cataract, Drug-Induced Toxicity
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
[+]

Postoperative tamoxifen for ductal carcinoma in situ does not reduce overall mortality. Dec 31, 2011

Pubmed Data : Cochrane Database Syst Rev. 2012 ;10:CD007847. Epub 2012 Oct 17. PMID: 23076938
Article Published Date : Dec 31, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Breast Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
[+]

Tamoxifen interferes with cognitive function in breast cancer patients. Nov 01, 2000

Pubmed Data : Breast Cancer Res Treat. 2000 Nov;64(2):165-76. PMID: 11194452
Article Published Date : Nov 01, 2000
Study Type : Meta Analysis
Additional Links
Diseases : Cognitive Decline/Dysfunction, Drug-Induced Toxicity , Memory Disorders: Drug-Induced
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Neurotoxic
[+]

Tamoxifen use may cause endometrial cancer, as well as being associated with poorer prognosis. May 04, 1998

Pubmed Data : Int J Cancer. 1998 May 4;76(3):325-30. PMID: 9579567
Article Published Date : May 04, 1998
Study Type : Meta Analysis
Additional Links
Diseases : Endometrial Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Two year treatment with Tamoxifen and Arimidex result in a number of side effects which reduce quality of life. Dec 01, 2006

Pubmed Data : Breast Cancer Res Treat. 2006 Dec;100(3):273-84. Epub 2006 Jun 21. PMID: 16944295
Article Published Date : Dec 01, 2006
Study Type : Meta Analysis
Additional Links
Diseases : Drug-Induced Toxicity
Additional Keywords : Drug: Tamoxifen
Problem Substances : Arimidex, Tamoxifen
[+]

Adjuvant tamoxifen therapy for early stage breast cancer increases the risk of second primarly malignancies such as endometrial, colon and somatch cancer.May 03, 1995

Pubmed Data : J Natl Cancer Inst. 1995 May 3;87(9):645-51. PMID: 7752269
Article Published Date : May 03, 1995
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Colorectal Cancer, Endometrial Cancer, Gastric Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Adjuvant treatment with aromatase inhibitors in breast cancer result in higher rates of hot flushes, musculoskeletal complaints, osteoporosis and fractures.Aug 01, 2006

Pubmed Data : Curr Med Res Opin. 2006 Aug;22(8):1609-21. PMID: 16870085
Article Published Date : Aug 01, 2006
Study Type : Human Study
Additional Links
Diseases : Bone Fractures, Breast Cancer, Drug-Induced Toxicity , Hot Flash, Musculoskeletal Complaints, Pain: Musculoskeletal
Additional Keywords : Drug: Tamoxifen
Problem Substances : Arimidex, Aromatase Inhibitor Drugs
[+]

Arimidex therapy contributes in the decline of bone mineral density in early breast cancer patients.Jan 01, 2010

Pubmed Data : Bratisl Lek Listy. 2010;111(1):27-32. PMID: 20429308
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Osteoporosis
Additional Keywords : Drug: Tamoxifen
Problem Substances : Arimidex, Aromatase Inhibitor Drugs, Letrozole (trade name Femera)
[+]

Aromatase inhibitors can induce an arthralgia syndrome.Jul 01, 2008

Pubmed Data : J Clin Oncol. 2008 Jul 1;26(19):3147-52. Epub 2008 May 12. PMID: 18474874
Article Published Date : Jul 01, 2008
Study Type : Human Study
Additional Links
Diseases : Arthralgia, Breast Cancer, Drug-Induced Toxicity , Musculoskeletal Abnormalities, Rheumatic Diseases
Additional Keywords : Drug: Tamoxifen
Problem Substances : Aromatase Inhibitor Drugs
[+]

Chemotherapy, but not a specific chemotherapy regimen, was associated with an increased risk of stroke.Apr 01, 2002

Pubmed Data : Free Radic Res. 2002 Apr;36(4):455-60. PMID: 15494603
Article Published Date : Apr 01, 2002
Study Type : Human Study
Additional Links
Diseases : Stroke
Additional Keywords : Drug: Tamoxifen
Anti Therapeutic Actions : Chemotherapy
[+]

Green tea reduces percent mammographic density in women at increased risk of breast cancer.Dec 01, 2017

Pubmed Data : Cancer Prev Res (Phila). 2017 Dec ;10(12):710-718. Epub 2017 Sep 13. PMID: 28904061
Article Published Date : Dec 01, 2017
Study Type : Human Study
Additional Links
Substances : Catechin , Tea
Diseases : Breast Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants
Additional Keywords : Drug: Tamoxifen, Plant Extracts
[+]

Higher estradiol levels are associated with gynecomastia.Nov 02, 1984

Pubmed Data : Dtsch Med Wochenschr. 1984 Nov 2 ;109(44):1678-82. PMID: 6489180
Article Published Date : Nov 02, 1984
Study Type : Human Study
Additional Links
Diseases : Estrogen Dominance, Gynecomastia
Additional Keywords : Diseases that are Linked, Drug: Tamoxifen
Problem Substances : 17beta-estradiol
[+]

Moderate coffee and alcohol consumption improves the estrogen metabolite profile in adjuvant treated breast cancer patients.Dec 01, 2006

Pubmed Data : Mol Genet Metab. 2006 Dec ;89(4):381-9. Epub 2006 Sep 15. PMID: 16978896
Article Published Date : Dec 01, 2006
Study Type : Human Study
Additional Links
Substances : Alcohol , Coffee
Diseases : Breast Cancer, Estrogen Dysregulation: 2/4/16 hydroxyestrone ratios
Additional Keywords : Drug: Tamoxifen
[+]

Raloxifene is associated with double the risk of coronary artery disease. Jan 01, 2009

Pubmed Data : Climacteric. 2009;12 Suppl 1:108-11. PMID: 19811253
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Diseases : Coronary Artery Disease
Additional Keywords : Drug: Tamoxifen
Problem Substances : Raloxifene
Adverse Pharmacological Actions : Cardiotoxic
[+]

Tamoxifen causes DNA adducs in the endometrium of women. Aug 01, 2000

Pubmed Data : Carcinogenesis. 2000 Aug;21(8):1461-7. PMID: 10910945
Article Published Date : Aug 01, 2000
Study Type : Human Study
Additional Links
Diseases : Endometrial Cancer, Endometrial Neoplasms
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic, Genotoxic, Mutagenic
[+]

Tamoxifen has been shown to cause endometrial cancer in humans.Mar 01, 2001

Pubmed Data : Eur J Obstet Gynecol Reprod Biol. 2001 Mar;95(1):105-10. PMID: 11267730
Article Published Date : Mar 01, 2001
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Endometrial Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Tamoxifen increases the risk of endometrial hyperplasia and carcinoma in breast cancer patients.Jan 01, 2003

Pubmed Data : Vopr Onkol. 2003;49(2):198-204. PMID: 12785205
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Diseases : Endometrial Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Tamoxifen may induce fatty liver in patients with breast cancer.Jan 01, 2003

Pubmed Data : AJR Am J Roentgenol. 2003 Jan;180(1):129-34. PMID: 12490491
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Diseases : Fatty Liver
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Hepatotoxic
[+]

Tamoxifen therapy has been associated with the development of acute myeloid leukemia during breast cancer treatment.Mar 01, 1997

Pubmed Data : Med Oncol. 1997 Mar;14(1):61-2. PMID: 9232614
Article Published Date : Mar 01, 1997
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Leukemia: Acute myelogenous leukemia (AML)
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Tamoxifen treatment for breast cancer in Japanese women results in an increased risk for endomentrial and stomach cancer.Dec 01, 2000

Pubmed Data : Ann Oncol. 2000 Dec;11(12):1537-43. PMID: 11205460
Article Published Date : Dec 01, 2000
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Endometrial Cancer, Gastric Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Tamoxifen treatment for breast cancer may result in fatty liver.Nov 01, 2000

Pubmed Data : Oncol Rep. 2000 Nov-Dec;7(6):1299-304. PMID: 11032933
Article Published Date : Nov 01, 2000
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Fatty Liver
Additional Keywords : Drug: 5-flourouracil, Drug: Doxorubicin, Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Hepatotoxic
[+]

Tamoxifen treatment for breast cancer results in one-third of all patients developing endometrial polyps, hyperplasia, metaplasia, consistent with an estrogen-agonist effect.Aug 01, 2000

Pubmed Data : Gynecol Oncol. 2000 Aug;78(2):181-6. PMID: 10926800
Article Published Date : Aug 01, 2000
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Endometrial Cancer, Endometrial Neoplasms
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Estrogen Agonist, Estrogenic
[+]

Tamoxifen treatment in breast cancer may induce non-alcoholic fatty liver.May 01, 2002

Pubmed Data : Intern Med. 2002 May;41(5):345-50. PMID: 12058881
Article Published Date : May 01, 2002
Study Type : Human Study
Additional Links
Diseases : Fatty Liver
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Hepatotoxic
[+]

Tamoxifen treatment increases the risk of endometrial cancer in both premenopausal and postmenopausal women Mar 02, 2005

Pubmed Data : J Natl Cancer Inst. 2005 Mar 2;97(5):375-84. PMID: 15741574
Article Published Date : Mar 02, 2005
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Endometrial Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Tamoxifen treatment results in adverse structural and functional changes in the brain in women. Jan 01, 2004

Pubmed Data : Neuroimage. 2004 Jan;21(1):364-71. PMID: 14741674
Article Published Date : Jan 01, 2004
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity , Memory Disorders: Drug-Induced
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Neurotoxic
[+]

Tamoxifen usage is associated with bone loss in patients who continued to menstruate after adjuvant chemotherapy.Feb 01, 2006

Pubmed Data : J Clin Oncol. 2006 Feb 1;24(4):675-80. PMID: 16446340
Article Published Date : Feb 01, 2006
Study Type : Human Study
Additional Links
Diseases : Osteoporosis
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
[+]

Tamoxifen use is associated with increased risk for endomentrial polyps and cancer.Dec 01, 2005

Pubmed Data : Gynecol Obstet Fertil. 2005 Dec;33(12):975-9. PMID: 16321556
Article Published Date : Dec 01, 2005
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Endometrial Cancer, Endometrial Neoplasms
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogen
[+]

The widespread use of tamoxifen as a preventive agent against breast cancer in healthy women may result in significantly elevated levels of endometrial cancer.Sep 09, 2000

Pubmed Data : Lancet. 2000 Sep 9;356(9233):881-7. PMID: 11036892
Article Published Date : Sep 09, 2000
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Endometrial Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Vegetable intake is associated with reduced breast cancer recurrence in tamoxifen users.Jul 06, 2010

Pubmed Data : Breast Cancer Res Treat. 2010 Jul 6. Epub 2010 Jul 6. PMID: 20607600
Article Published Date : Jul 06, 2010
Study Type : Human Study
Additional Links
Substances : Vegetables: All
Diseases : Breast Cancer
Pharmacological Actions : Drug synergy
Additional Keywords : Drug: Tamoxifen
[+]

Women treated with tamoxifen in the adjuvant setting experienced symptoms of sexual dysfunction.May 01, 1999

Pubmed Data : J Clin Oncol. 1999 May;17(5):1488-92. PMID: 10334535
Article Published Date : May 01, 1999
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity , Sexual Dysfunction
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
[+]

Dietary flaxseed interacts positively with tamoxifen to induce breast tumor regression. Jan 01, 2007

Pubmed Data : Nutr Cancer. 2007;58(2):162-70. PMID: 17640162
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Substances : Flaxseed
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Drug: Tamoxifen, Drug-Plant-Vitamin Synergies
[+]

Grape seed extract, black seed extract and curcumin ameliorate tamoxifen-induced liver injury.Jan 01, 2007

Pubmed Data : Hepatogastroenterology. 2007 Jan-Feb;54(73):320-4. PMID: 21046982
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Substances : Curcumin, Grape Seed Extract, Nigella sativa (aka Black Seed)
Diseases : Chemically-Induced Liver Damage, Chemotherapy-Induced Toxicity: Tamoxifen, Drug-Induced Toxicity
Pharmacological Actions : Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Drug: Tamoxifen, Plant Extracts
[+]

Soy phytochemicals synergistically enhance the preventive effect of tamoxifen on the growth of estrogen-dependent human breast carcinoma in mice.Jun 01, 2007

Pubmed Data : Carcinogenesis. 2007 Jun;28(6):1217-23. Epub 2007 Jan 18. PMID: 17234721
Article Published Date : Jun 01, 2007
Study Type : Animal Study
Additional Links
Substances : Genistein, Soy
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Chemosensitizer
Additional Keywords : Drug: Tamoxifen, Drug Synergy
[+]

Tamoxifen causes DNA damage in multiple organs of adult femaile cynomolgus monkeys.Sep 15, 2003

Pubmed Data : Cancer Res. 2003 Sep 15;63(18):5999-6003. PMID: 14522927
Article Published Date : Sep 15, 2003
Study Type : Animal Study
Additional Links
Diseases : DNA damage
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Genotoxic
[+]

Tamoxifen enhances bladder and liver cancer carcinogenesis in mice exposed to arsenic. Sep 15, 2006

Pubmed Data : Toxicol Appl Pharmacol. 2006 Sep 15;215(3):295-305. Epub 2006 May 18. PMID: 16712894
Article Published Date : Sep 15, 2006
Study Type : Animal Study
Additional Links
Diseases : Arsenic Poisoning, Bladder Cancer, Liver Cancer
Additional Keywords : Drug: Tamoxifen, Drug-Plant-Vitamin Synergies
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Tamoxifen impairs both longitudinal and cortical bone growth in young male rats.Aug 01, 2008

Pubmed Data : J Bone Miner Res. 2008 Aug;23(8):1267-77. PMID: 18348701
Article Published Date : Aug 01, 2008
Study Type : Animal Study
Additional Links
Diseases : Bone Diseases
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Endocrine Disruptor
[+]

Tamoxifen induces endometrial and vaginal cancer in rats in the absence of endometrial hyperplasia.Apr 01, 2000

Pubmed Data : Carcinogenesis. 2000 Apr;21(4):793-7. PMID: 10753217
Article Published Date : Apr 01, 2000
Study Type : Animal Study
Additional Links
Diseases : Cervical Cancer, Endometrial Cancer, Vaginal Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Tamoxifen is a liver carcinogen in rats.Sep 28, 2001

Pubmed Data : Cancer Lett. 2001 Sep 28;171(1):27-35. PMID: 11485825
Article Published Date : Sep 28, 2001
Study Type : Animal Study
Additional Links
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Tamoxifen metabolites exhibit genotoxic activity.Dec 01, 2001

Pubmed Data : Chem Res Toxicol. 2001 Dec;14(12):1643-53. PMID: 11743747
Article Published Date : Dec 01, 2001
Study Type : Animal Study
Additional Links
Diseases : Breast Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Genotoxic
[+]

Tanshinone IIA, a compound found within Red Sage, has potential anti-cancer activity that is stronger than tamoxifen in both ER-positive and ER-negative breast cancers.Dec 01, 2009

Pubmed Data : Int J Mol Med. 2009 Dec;24(6):773-80. PMID: 19885617
Article Published Date : Dec 01, 2009
Study Type : Transgenic Animal Study
Additional Links
Substances : Red Sage
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Drug: Tamoxifen, Superiority of Natural Substances versus Drugs
[+]

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.Jan 06, 2011

Pubmed Data : Nature. 2011 Jan 6;469(7328):102-6. Epub 2010 Nov 28. PMID: 21113150
Article Published Date : Jan 06, 2011
Study Type : Animal Study
Additional Links
Diseases : Aging
Pharmacological Actions : Antiproliferative , Telomerase Upregulation
Additional Keywords : Drug: Tamoxifen
[+]

The developmental and reproductive toxicity observed in animals given tamoxifen may be due to the oxidative stress it induces.Mar 02, 2001

Pubmed Data : Life Sci. 2001 Mar 2;68(15):1735-49. PMID: 11270620
Article Published Date : Mar 02, 2001
Study Type : Animal Study
Additional Links
Diseases : Oxidative Stress
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Oxidant
[+]

These results indicate the use of formononetin in the prevention of breast cancer carcinogenesis.Aug 31, 2011

Pubmed Data : Horm Metab Res. 2011 Sep ;43(10):681-6. Epub 2011 Sep 19. PMID: 21932171
Article Published Date : Aug 31, 2011
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest
Additional Keywords : Drug: Tamoxifen
[+]

An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride.Mar 31, 2014

Pubmed Data : Crit Rev Toxicol. 2014 Apr ;44(4):348-91. Epub 2014 Feb 4. PMID: 24494825
Article Published Date : Mar 31, 2014
Study Type : Review
Additional Links
Diseases : DNA damage
Additional Keywords : Drug: Tamoxifen
Problem Substances : Aflatoxin, Tamoxifen, Vinyl chloride
Adverse Pharmacological Actions : Carcinogenic, Genotoxic, Mutagenic
[+]

Antineoplaston A10 is an agent found within human urine, has anti-cancer properties (especially in hormone sensitive cancers). Jan 01, 1988

Pubmed Data : J Steroid Biochem. 1988 ;30(1-6):325-8. PMID: 3133525
Article Published Date : Jan 01, 1988
Study Type : Review
Additional Links
Substances : Urine
Diseases : Breast Cancer
Additional Keywords : Drug: Tamoxifen
[+]

Apigenin and luteolin are potent inhibitors of human thyroid cancer cell lines. Apr 01, 1999

Pubmed Data : Thyroid. 1999 Apr;9(4):369-76. PMID: 10319943
Article Published Date : Apr 01, 1999
Study Type : In Vitro Study
Additional Links
Substances : Apigenin, Flavonoids, Luteolin
Diseases : Thyroid Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Drug: Tamoxifen
[+]

Curcumin reduces NF-kappa B factor activation associated with anticancer drugs. Dec 01, 2009

Pubmed Data : Endocr Relat Cancer. 2009 Dec;16(4):1339-50. Epub 2009 Sep 2. PMID: 12007574
Article Published Date : Dec 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy, Chemotherapy-Induced Toxicity
Pharmacological Actions : Antineoplastic Agents, NF-kappaB Inhibitor
Additional Keywords : Drug: Doxorubicin, Drug: Tamoxifen
[+]

EGCG exhibits anti-cancer activity against tamoxifen-resistant breast cancer lines.Apr 01, 2011

Pubmed Data : Biosci Rep. 2011 Apr ;31(2):99-108. PMID: 20446926
Article Published Date : Apr 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Catechin
Diseases : Breast Cancer, Cancer Metastasis, Cancers: Drug Resistant
Pharmacological Actions : Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords : Drug: Tamoxifen, Tamoxifen Resistance
[+]

EGCG is capable of killing tamoxifen-resistant breast cancer cells.Jan 01, 2007

Pubmed Data : Cancer Detect Prev. 2007 ;31(6):499-504. PMID: 18061364
Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Catechin
Diseases : Breast Cancer
Pharmacological Actions : Anticarcinogenic Agents, Estrogen Receptor Modulators
Additional Keywords : Drug: Tamoxifen, Tamoxifen Resistance
[+]

EPA may be useful for the treatment of tamoxifen-resistant breast cancer cells with high levels of activated Akt .Jun 30, 2003

Pubmed Data : Ann Oncol. 2003 Jul ;14(7):1051-6. PMID: 12853346
Article Published Date : Jun 30, 2003
Study Type : In Vitro Study
Additional Links
Substances : EPA (Eicosapentaenoic Acid)
Diseases : Breast Cancer, Cancers: Drug Resistant
Additional Keywords : Drug: Tamoxifen, Tamoxifen Resistance
Problem Substances : Tamoxifen
[+]

Genistein sensitizes inhibitory effect of tamoxifen on the growth of estrogen receptor-positive and HER2-overexpressing human breast cancer cells.Jul 01, 2007

Pubmed Data : Mol Carcinog. 2007 Jul;46(7):534-42. PMID: 17295235
Article Published Date : Jul 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Genistein
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer, Drug synergy
Additional Keywords : Drug: Tamoxifen, Drug Synergy
[+]

Pterostilbene and tamoxifen show an additive effect against breast cancer in vitro.Nov 01, 2010

Pubmed Data : Am J Surg. 2010 Nov;200(5):577-80. PMID: 21056131
Article Published Date : Nov 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Pterostilbene
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Drug: Tamoxifen, Drug Synergy, Stilbenes
[+]

Quercetin Inhibits angiogenesis in tamoxifen-resistant breast cancer cells.Oct 31, 2010

Pubmed Data : Food Chem Toxicol. 2010 Nov ;48(11):3227-34. Epub 2010 Sep 4. PMID: 20804812
Article Published Date : Oct 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Breast Cancer, Cancers: Drug Resistant
Pharmacological Actions : Anti-Angiogenic, Antioxidants, Vascular Endothelial Growth Factor A Inhibitor
Additional Keywords : Drug: Tamoxifen, Tamoxifen Resistance
Problem Substances : Tamoxifen
[+]

Tamoxifen has a proliferative effecct against endometrial cancer cells.Sep 01, 2004

Pubmed Data : Oncol Rep. 2004 Sep;12(3):517-21. PMID: 15289830
Article Published Date : Sep 01, 2004
Study Type : In Vitro Study
Additional Links
Diseases : Endometrial Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic, Estrogen Agonist, Proliferative
[+]

Tamoxifen has both antagonistic and agonistic effects on estrogen receptors, indicating it may have carcinogenic potential in estrogen sensitive cancers.Feb 01, 1997

Pubmed Data : Semin Oncol. 1997 Feb;24(1 Suppl 1):S1-71-S1-80. PMID: 9045319
Article Published Date : Feb 01, 1997
Study Type : Review
Additional Links
Diseases : Endometrial Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Estrogenic
[+]

Tamoxifen induces lesions in endometrial tissues associated with DNA damage and cancer.May 01, 1999

Pubmed Data : Cancer Res. 1999 May 1;59(9):2091-5. PMID: 10232593
Article Published Date : May 01, 1999
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic, Genotoxic, Mutagenic
[+]

Tamoxifen is a carcinogen in the human uterus and rat liver.May 01, 2004

Pubmed Data : Cancer Res. 2004 May 1;64(9):3144-7. PMID: 15126352
Article Published Date : May 01, 2004
Study Type : Commentary
Additional Links
Diseases : DNA damage, Endometrial Cancer, Uterine Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Tamoxifen is genotoxic and carcinogenic to endometrial cells.May 01, 2004

Pubmed Data : Drug Metab Rev. 2004 May;36(2):199-218. PMID: 15237851
Article Published Date : May 01, 2004
Study Type : In Vitro Study
Additional Links
Diseases : Endometrial Cancer, Endometrial Neoplasms
Additional Keywords : Drug: Tamoxifen
Problem Substances : Paracetamol
Adverse Pharmacological Actions : Genotoxic, Mutagenic
[+]

Tamoxifen may induce endometrial cancer.Jan 01, 2006

Pubmed Data : Ann Ist Super Sanita. 2006;42(2):170-3. PMID: 17033137
Article Published Date : Jan 01, 2006
Study Type : Review
Additional Links
Diseases : Endometrial Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Tamoxifen may induce non-alcoholic fatty liver.Jan 01, 2007

Pubmed Data : Expert Opin Drug Saf. 2007 Jan;6(1):1-4. PMID: 17181445
Article Published Date : Jan 01, 2007
Study Type : Review
Additional Links
Diseases : Chemically-Induced Liver Damage, Fatty Liver
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen

Drug: Tamoxifen Related Articles

Tamoxifen: Praised As "Life Saving" But Still Causing Cancer
Written by Sayer Ji, Founder
Many of the drugs used to treat breast cancer today are probable or known cancer-causing agents. Tamoxifen, for instance, is classified by the World Health Organization as a "human carcinogen," but recent news headlines praised extended use of this drug for "saving lives." It is obvious that the mainstream media has swallowed the tamoxifen-flavored Kool-Aid ... will you?

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