Gene Expression Regulation

Name	AC	CK
Bisphenol A	2	6
Doxorubicin	1	5
Acetaminophen	2	4
Aflatoxin	2	4
Sodium Fluoride	2	4
Aluminum	2	3
Mercury	2	3
Calcium Carbonate	1	2
Formaldehyde	1	2
Glyphosate	1	2
Indomethacin	1	2
Insulin	1	2
Lead	1	2
Paracetamol	1	2
Pesticides	1	2
Meat: Cooked	1	1
Paraquat	1	1
Polycyclic aromatic hydrocarbon	1	1

Name	AC	CK
Inflammation	35	119
Obesity	54	104
Oxidative Stress	31	86
Diabetes Mellitus: Type 2	22	81
Breast Cancer	39	70
High Fat Diet	33	65
Lung Cancer	23	48
Polycystic Ovary Syndrome	5	42
Vitamin D Deficiency	7	36
Aging	14	33
Nonalcoholic fatty liver disease (NAFLD)	17	30
Colon Cancer	17	29
Prostate Cancer	17	29
Alzheimer's Disease	17	28
Colorectal Cancer	18	26
Liver Cancer	18	23
Diabetes Mellitus: Type 2: Prevention	3	22
Gestational Diabetes	3	22
Insulin Resistance	12	22
Cancers: All	15	21
DNA damage	6	21
Hyperlipidemia	7	21
C-Reactive Protein	2	20
Carcinoma: Non-Small-Cell Lung	7	19
Wound Healing	5	19
Oral Cancer	7	18
Cancers: Drug Resistant	8	17
Atherosclerosis	9	16
Hypercholesterolemia	8	16
Osteoarthritis	4	15
Metabolic Diseases	7	14
Multiple Sclerosis	7	14
Hepatic Steatosis	7	13
Rheumatoid Arthritis	3	13
Stress	3	13
Ulcerative Colitis	3	13
Asthma	3	12
Breast Cancer: Triple Negative	12	12
Cognitive Decline/Dysfunction	7	12
Coronary Artery Disease	2	12
Hypertension	2	12
Systemic Lupus Erythematosus	2	12
Diabetes Mellitus: Type 1: Prevention	2	11
Diabetic Complications	6	11
Acne	1	10
Anemia: Sickle Cell	1	10
Back Pain	1	10
Breast Cancer: BRCA1	1	10
Breast Cancer: Drug Resistant	2	10
Carcinoma: Small Cell Lung	1	10
Cervical Cancer	10	10
Diabetes: Gestational	1	10
Endothelial Dysfunction	1	10
Fibrosarcoma	1	10
Glaucoma	1	10
Glioblastoma Multiforme	1	10
Irritable Bowel Syndrome	1	10
Kidney Failure: Chronic	1	10
Leukemia: Monocytic	1	10
Lung Cancer: Metastatic	1	10
Metabolic Syndrome X	6	10
Miscarriage: Recurrent	1	10
Schizophrenia	1	10
Sitting Sickness	1	10
Thalassemia	1	10
Diabetes Mellitus: Type 1	5	9
Gastric Cancer	8	9
Lipid Peroxidation	5	9
Chemically-Induced Liver Damage	4	8
Diabetic Nephropathy	4	8
Alcoholic Liver Disease	4	7
Glioblastoma	3	7
Graves Disease	2	7
Bisphenol Toxicity	2	6
Bladder Cancer	5	6
Cancer Metastasis	3	6
Liver Steatosis	3	6
Memory Loss	3	6
Pancreatic Cancer	5	6
Astrocytoma	1	5
Breast Cancer: Metastatic	3	5
Chronic Obstructive Pulmonary Disease	1	5
Colon Cancer: Prevention	3	5
Dyslipidemias	3	5
Hydrogen Peroxide Induced Toxicity	1	5
Leukemia: Chronic myelogenous leukemia (CML)	1	5
Liver Cirrhosis	3	5
Liver Damage	3	5
Muscle Atrophy	3	5
Non-Small-Cell Lung Carcinoma	1	5
Osteoporosis	3	5
Periodontal Diseases	1	5
Squamous cell carcinoma	4	5
Triglycerides: Elevated	3	5
Tuberculosis	1	5
Acetaminophen (Tylenol) Toxicity	2	4
Acute Myeloid Leukemia	4	4
Advanced Glycation End products (AGE)	3	4
Alcohol Toxicity	2	4
Cachexia	2	4
Circadian Dysregulation	2	4
Colitis	2	4
Down Syndrome	2	4
Fluoride Toxicity	2	4
Infertility: Male	2	4
Kidney Fibrosis	2	4
Leukemia	3	4
Lipopolysaccharide-Induced Toxicity	3	4
Lung Injury: Acute	2	4
Lymphoma	2	4
Sleep Disorders	2	4
Stroke: Attenuation/Recovery	2	4
Varicocele	2	4
Werner Syndrome	2	4
Aluminum Toxicity	2	3
Autoimmune Diseases	2	3
Breast Cancer: Chemically-Induced	2	3
Breast Cancer: Lung Metastasis	2	3
Candida Albicans	3	3
Cardiovascular Diseases	3	3
Dementia	2	3
Depression	2	3
Escherichia coli Infections	3	3
Fibrosis	2	3
Hyperglycemia	2	3
Inflammatory Bowel Diseases	2	3
Kidney Damage: Chemically-Induced	2	3
Liver Fibrosis	2	3
Melanoma	3	3
Memory Disorders	2	3
Ovarian Cancer	3	3
Periodontitis	2	3
Prostate Cancer: Prevention	2	3
Pseudomonas aeruginosa	3	3
Staphylococcus aureus: Methicillin-resistant (MRSA)	3	3
Ultraviolet Radiation Induced Damage	2	3
Acute Respiratory Distress Syndrome	1	2
Aflatoxicosis	1	2
Amnesia	1	2
Arthritis	1	2
Atopic Dermatitis	1	2
Autoimmune Thyroiditis	1	2
Bacterial Infections	1	2
Brain Edema	1	2
Brain Hypoxia	1	2
Brain Injury: Traumatic	1	2
Cachexia: Cancer	1	2
Cachexia: Chemotherapy Induced	1	2
Cancer Mortality	1	2
Cancers: Radiation-Resistant	1	2
Cardiac Hypertrophy	1	2
Cardiomyopathy	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chemotherapy-Induced Toxicity: Peripheral Neuropathy	1	2
Cholestasis	1	2
Chronic Kidney Disease (CKD)	1	2
Chronic Myeloid Leukemia	2	2
Clostridium Infections	1	2
Cocaine Withdrawal	1	2
Degenerative Disk Disease	1	2
Demyelinating Diseases	1	2
Diabetes: Oxidative Stress	1	2
Diabetic Retinopathy	1	2
Dry Eye Syndromes	1	2
Dysbiosis: Bifidobacteria Deficiency	1	2
Dyspepsia	1	2
Encephalomyelitis	1	2
Epilepsy	1	2
Fatty Liver	1	2
Fetal Origin of Adult Disease	1	2
Fish Diseases	1	2
Gastric Ulcer	1	2
Glyphosate Toxicity	1	2
Hearing Loss	1	2
Heart Failure	1	2
Hepatitis C	1	2
Herpes Simplex Virus Type 1	2	2
Hirschsprung Disease	1	2
Hypoglycemia	1	2
Infection: Antibiotic Resistant	2	2
Intracerebral Hemorrhage	1	2
Kidney Cancer	2	2
Kidney Damage	1	2
Liver Damage: Aflatoxin-Induced	1	2
Lung Diseases	1	2
Mercury Poisoning	1	2
Neurodegenerative Diseases	2	2
Nicotine/Tobacco Toxicity	1	2
Peripheral Neuropathies	1	2
Porphyromonas gingivalis	1	2
Prediabetes	1	2
Psoriasis	1	2
Pulmonary Emphysema	1	2
Pulmonary Fibrosis	1	2
Salmonella Infections	2	2
Seizures	1	2
Sepsis	1	2
Sjogren's Syndrome	1	2
Snake Bite: Venom Toxicity	1	2
Steptococcus Mutans Infections	2	2
Stroke	1	2
Tendon Injury	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Testosterone: Too Low	1	2
Thyroid Diseases	1	2
Tinnitus	1	2
Xerostomia	1	2
AIDS	1	1
Aging Skin	1	1
Aging: Brain	1	1
Allergic Rhinitis	1	1
Amyotrophic lateral sclerosis (ALS)	1	1
Anxiety	1	1
Autism Spectrum Disorders	1	1
Avian Influenza	1	1
Bile Duct Cancer	1	1
Blue Light Toxicity	1	1
Bone Diseases	1	1
Bone Fractures	1	1
Brain Cancer	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Burkitt Lymphoma	1	1
Candidiasis: Vulvovaginal	1	1
Central Nervous System Diseases	1	1
Chemotherapy-Induced Toxicity: Cisplatin	1	1
Cholangiocarcinoma	1	1
Chronic Disease	1	1
Chronic Lymphocytic Leukemia	1	1
Cytomegalovirus Infections	1	1
Endometrial Cancer	1	1
Esophageal Cancer	1	1
Gastrointestinal Diseases	1	1
Gram-Negative Bacterial Infections	1	1
H5N1 Infection	1	1
HIV Drug-Induced Toxicity	1	1
HIV Infections	1	1
Head and Neck Cancer	1	1
Heart Disease	1	1
Helicobacter Pylori Infection	1	1
Hepatitis B	1	1
Herpes Simplex Virus Type 2	1	1
Human Papillomavirus (HPV)	1	1
Influenza	1	1
Insulin Disorders	1	1
Keloid	1	1
Lung Cancer: Prevention	1	1
Nasopharyngeal Cancer	1	1
Neuroblastoma	1	1
Parkinson's Disease	1	1
Pesticide Toxicity	1	1
Post-Traumatic Stress Disorders (PTSD)	1	1
Prenatal Nutrition: Prevention of Problems	1	1
Promyelocytic leukemia	1	1
Rhabdomyosarcoma	1	1
Shigellosis	1	1
Skin Cancer	1	1
Skin Cancer: Prevention	1	1
Skin Diseases	1	1
Spinal Cord Injuries	1	1
Thyroid Cancer	1	1
Toxoplasma gondii Infection	1	1
Urinary Tract Infections	1	1
Viral Hemorrhagic Septicemia virus (VHSV)	1	1

Name	AC	CK
Western Diet	2	4
Low Dose Ionizing Radiation	1	2
Blue Light (400−495 nm)	1	1

Name	AC	CK
Vitamin D	18	86
Curcumin	44	69
Vitamin C	14	43
Sulforaphane	8	32
EGCG (Epigallocatechin gallate)	18	30
Broccoli Sprouts	3	22
Lactobacillus rhamnosus GG	3	22
Omega-3 Fatty Acids	3	22
Flavonoids	14	21
Thymoquinone	11	19
Cannabinoids	4	18
Lactobacillus plantarum	5	18
Berberine	10	17
Genistein	7	17
Black Raspberry	4	16
Fish Oil	4	16
Ginger	6	16
Quercetin	8	16
Amurensin G	3	15
Polyphenols	10	14
Resveratrol	11	14
Coenzyme Q10	3	13
Flaxseed	3	13
Shilajit	2	13
Water: Deuterium Depleted	3	13
Delta-tetrahydrocannabinol (THC)	2	12
Ellagic Acid	5	12
Garlic	3	12
Zinc	2	12
Alpha-Lipoic Acid	5	11
Chlorella (Algae)	1	10
Indole-3-Carbinol	1	10
Lactobacillus gasseri	1	10
Magnesium	1	10
Myo-inositol	1	10
Passion Flower	1	10
Persimmon	1	10
Pycnogenol (Pine Bark)	1	10
Vitamin B-12	1	10
Nigella sativa (aka Black Seed)	3	9
Turmeric	6	9
Astaxanthin	5	8
Bacopa	4	8
Kaempferol	4	8
Dragon Fruit	4	7
Ginsenosides	6	7
Myricetin	2	7
Propolis: Bee	2	7
Royal Jelly	4	7
Taurine	2	7
Anthocyanins	4	6
Cannabidiol	5	6
Fucoidan	3	6
Ginseng (Korean)	3	6
Green Tea	4	6
Lychee	3	6
Reishi Mushroom	4	6
Rutin	3	6
Seaweed	3	6
Spirulina	3	6
Tomato	3	6
Apigenin	3	5
Babchi	1	5
Bisdemethoxycurcumin	1	5
Blueberry	3	5
DHA (Docosahexaenoic Acid)	4	5
Diosgenin	3	5
Folic Acid	3	5
Melatonin	3	5
Mushrooms: All	1	5
Nobiletin	3	5
Peony	3	5
Propolis: Brazillian	1	5
Silibinin	3	5
Ursolic Acid	4	5
Walnut	3	5
Angelica	2	4
Astragalus	2	4
Baccharis trimera	2	4
Bee Venom	3	4
Bitter Melon	2	4
Black Currant	2	4
Cannabis	3	4
Carvacrol	2	4
Chlorogenic Acid	2	4
Cinnamon	2	4
Cranberry	3	4
Crocin	2	4
EPA (Eicosapentaenoic Acid)	3	4
Ferulic acid	3	4
Guarana	2	4
Hesperidin	2	4
Lingonberry	2	4
Magnolol	3	4
Moringa oleifera	2	4
Mulberry	2	4
Piperine	3	4
Puerarin	2	4
Safflower	2	4
Shiitake Mushroom	2	4
Tetrahydrocurcumin	2	4
Vitamin E	2	4
Andrographolide	2	3
Ashwagandha	2	3
Astragaloside	2	3
Bee Propolis	3	3
Chokeberry	2	3
Coffee	2	3
Curcuminoids	2	3
Dandelion	2	3
Fisetin	3	3
Ginseng	2	3
Green Coffee Bean	2	3
Guduchi	3	3
Honokiol	2	3
Kimchi	2	3
Lactobacillus casei	2	3
Lactobacillus rhamnosus	3	3
Lactoferrin	2	3
Licorice	2	3
Luteolin	3	3
Magnolia	2	3
Mangosteen	2	3
Marjoram	2	3
Onion	2	3
Organosulfur Compounds	2	3
Pomegranate	3	3
Pterostilbene	2	3
Saffron	2	3
Shikonin	2	3
Strawberry	2	3
Syrian rue	2	3
Urolithin A	2	3
Vitamin K2	2	3
Wasabi	2	3
Xanthohumol	2	3
Acai	1	2
Achiote	1	2
Agaricus brasiliensis	1	2
Allicin	1	2
Aloe Vera	1	2
Apple	1	2
Baicalein	2	2
Beta-glucan	1	2
Betaine	1	2
Bilberry	1	2
Black Tea	1	2
Blue Honeysuckle	1	2
Brown Rice: Pre-Germinated	1	2
Burdock	1	2
Caffeic acid phenethyl ester	1	2
Capparis spinosa (caper)	1	2
Carnosic Acid	2	2
Cashew	1	2
Celastrol	1	2
Chia	1	2
Chlorophyllin	1	2
Chrysanthemum Indicum	1	2
Chrysin	2	2
Cinnamaldehyde	1	2
Citrus naringin	1	2
Cocoa	1	2
Common bean	1	2
Cryptoxanthin	1	2
Cucurbitacin B	1	2
Cucurbitacin E	2	2
Echinacea	1	2
Elderberry	1	2
Eugenol	2	2
Evening Primrose Oil	1	2
Flaxseed Oil	1	2
Fruit: All	1	2
Ginkgo biloba	1	2
Glutathione	1	2
Gotu Kola	1	2
Grape	2	2
Hemp Seed	1	2
Honey	2	2
Huaier (Trametes robiniophila murr)	2	2
Hydrogen Water	1	2
Indian Mulberry	1	2
Kombucha Tea	1	2
Krill	1	2
Lactobacillus Acidophilus	1	2
Lactobacillus probiotics	2	2
Lactobacillus salivarius	1	2
Lignans	1	2
Litchi	1	2
Lupeol	2	2
Lycopene	1	2
Mucuna pruriens (aka Velvet Beans)	1	2
Naringenin	1	2
Noni leaf extract	1	2
Octacosanol	1	2
Okra	1	2
Oleanolic acid	1	2
Oligonol	1	2
Paeoniflorin	1	2
Panax Notoginseng	1	2
Pantethine	1	2
Parthenolide	1	2
Peach	1	2
Pectin	1	2
Phloretin	2	2
Pineapple	1	2
Pistachio nut	1	2
Plum	1	2
Policosanol	1	2
Pomegranate flower	1	2
Prebiotics	1	2
Probiotics	1	2
Pueraria mirifica	1	2
Red Wine	1	2
Rice Bran	1	2
Rice: Black	1	2
Rosemary	2	2
Selenium	1	2
Sesame Seed Oil	1	2
Sesamin	1	2
Solanum Glaucophyllum	1	2
Soursop	1	2
Tea: Oolong	1	2
Theanine	2	2
Theophylline	1	2
Thyme	1	2
Trichosanthes Kirilowii	1	2
Triptolide	1	2
Turmerones	1	2
Ubiquinol	1	2
Vegetables: All	1	2
Vinegar	1	2
Vitamin D3	1	2
Water: Deep Sea	1	2
Whey	1	2
Wogonin	1	2
Yarrow	1	2
beta-Carotene	1	2
2,3,5,4'-tetrahydroxystilbene-2-O-β -D-glucoside (THSG)	1	1
6-Shogaol	1	1
Adlay	1	1
Amygdalin (laetrile)	1	1
Andrographis	1	1
Antrodia camphorata	1	1
Artichoke	1	1
Asiatic Acid	1	1
Bacillus Clausii	1	1
Barberry	1	1
Basil	1	1
Benzyl isothiocyanate	1	1
Bergamot	1	1
Beta-Elemene	1	1
Betulinic acid	1	1
Biochanin A	1	1
Black Pepper	1	1
Butterfly Pea	1	1
Caffeic Acid	1	1
Camel Milk	1	1
Cannabigerol	1	1
Carnosol	1	1
Catechin	1	1
Chickpea	1	1
Clove	1	1
Cordyceps Militaris	1	1
Cruciferous Vegetables	1	1
Cucurbitacin D	1	1
Daidzein	1	1
Delphinidin	1	1
Eriodictyol	1	1
Evodiamine	1	1
Fenugreek	1	1
Fermented Foods and Beverages	1	1
Feverfew	1	1
Fig	1	1
Flax Straw	1	1
Folate	1	1
Formononetin	1	1
Frankincense	1	1
Fucoxanthin	1	1
Garcinia cambogia	1	1
Goji	1	1
Guggul	1	1
Gynostemma	1	1
Hazelnut	1	1
Hibiscus	1	1
Homeopathic Medicine: All	1	1
Hyperforin	1	1
Iodine	1	1
Isothiocyanates	1	1
Japanese cypress	1	1
Kahweol	1	1
Lactobacillus fermentum	1	1
Lactobacillus paracasei	1	1
Lactobacillus reuteri	1	1
Lavender: Essential Oil	1	1
Lettuce	1	1
Lichens	1	1
Lotus	1	1
Lysergic Acid Diethylamide (LSD)	1	1
Mangiferin	1	1
Manuka Honey	1	1
Maple Syrup	1	1
Maqui	1	1
Medicinal Mushrooms	1	1
Mugwort	1	1
Mustard Oil	1	1
Nettle	1	1
Nicotinamide	1	1
Nisin	1	1
Oleocanthal	1	1
Oleuropein	1	1
Olive leaf extract	1	1
Orange	1	1
Papaya	1	1
Patchouli	1	1
Peppermint	1	1
Perilla	1	1
Polyunsaturated Fatty Acids (PUFAs)	1	1
Prickly Pear Cactus	1	1
Procyanidin B2	1	1
Psilocybin	1	1
Psychedelics:All	1	1
Pumpkin	1	1
Rooibos	1	1
Rose	1	1
Rosmarinic acid	1	1
Sea buckthorn	1	1
Sesamol	1	1
St. Johns Wort	1	1
Sweet Potato	1	1
Sweet Potato: Purple	1	1
Tamarind	1	1
Tanshinone IIA	1	1
Theaflavins	1	1
Thiamine (B-1)	1	1
Thymol	1	1
Vitamin E: Gamma-tocotrienol	1	1
Yellow Sweet Clover (Melilotus officinalis)	1	1
Yerba Mate	1	1

Name	AC	CK
Meditation	4	31
Exercise	7	21
Exercise: Aerobic	2	20
Yoga	2	20
Yogic Technique: Sudarshan kriya	2	20
Mindfullness Training	2	11
Exercise: Endurance	1	10
Spa Bathing	1	10
Light-Emitting Diodes (LEDs) Therapy	2	7
Laser Treatment: Low-Level	2	3
Hyperbaric Treatment	1	2
Aromatherapy	1	1
Breastfeeding	1	1

Name	AC	CK
Anti-Inflammatory Agents	99	329
Antioxidants	69	162
Apoptotic	74	146
Antiproliferative	85	134
Tumor Necrosis Factor (TNF) Alpha Inhibitor	32	103
Immunomodulatory	26	88
Hepatoprotective	38	68
Hypolipidemic	31	66
Chemopreventive	42	65
MicroRNA modulator	29	65
Cell cycle arrest	35	64
Neuroprotective Agents	35	59
NF-kappaB Inhibitor	25	55
Chemotherapeutic	29	49
Anti-metastatic	32	46
Anticholesteremic Agents	16	46
Hypoglycemic Agents	15	44
Interleukin-6 Downregulation	13	39
Anticarcinogenic Agents	24	38
Interleukin-1 beta downregulation	12	38
Antineoplastic Agents	9	27
Nrf2 activation	8	25
Anti-Apoptotic	8	23
Cyclooxygenase 2 Inhibitors	11	23
Gastrointestinal Agents	11	21
Interleukin-8 downregulation	3	21
Superoxide Dismutase Up-regulation	6	19
Angiogenesis Inhibitors	7	18
Cardioprotective	10	18
Malondialdehyde Down-regulation	5	18
Renoprotective	10	18
Vascular Endothelial Growth Factor Inhibitors	7	18
Chemosensitizer	8	17
Catalase Up-Regulation	3	13
Histone deacetylase inhibitor	2	12
Enzyme Inhibitors	5	11
Anti Inflammatory	1	10
Anti-Bacterial Agents	10	10
Antimicrobial	8	10
Antiviral Agents	9	10
Interleukin-12 downregulation	1	10
Interleukin-23 Downregulation	1	10
Anti-Adipogenic	4	9
Cytoprotective	3	8
Hypoxia-inducible factor-1 (HIF-1) inhibitor	3	8
Matrix metalloproteinase-2 (MMP-2) inhibitor	7	8
Anti-Tumor	2	7
Anti-atherogenic	4	7
Vascular Endothelial Growth Factor A Inhibitor	2	7
Anti-Angiogenic	2	6
Autophagy Up-regulation	2	6
Gastroprotective	3	6
Genoprotective	3	6
Heme oxygenase-1 up-regulation	4	6
Matrix metalloproteinase-9 (MMP-9) inhibitor	6	6
Wnt/β-catenin signaling pathway modulation	4	6
Anti-Fibrotic	3	5
Insulin Sensitizers	3	5
Interleukin-17 downregulation	3	5
Tumor Suppressor Protein p53 Upregulation	5	5
Autophagy Inhibitors	3	4
Chemoprotective Agents	2	4
Chondroprotective	2	4
Cytotoxic	3	4
Detoxifier	2	4
Fibroblast growth factor 21 upregulation	2	4
Interleukin-10 upregulation	2	4
Matrix metalloproteinase-1 (MMP-1) inhibitor	2	4
Matrix metalloproteinase-3 (MMP-3) inhibitor	2	4
Nitric Oxide Inhibitor	3	4
Osteoprotective	3	4
Pancreato Protective Agents	3	4
Prophylactic Agents	3	4
Remyelination	2	4
Angiogenesis Inducing Agents	1	3
Antihypertensive Agents	2	3
Antioxidant Effects	2	3
Bcl-2 protein down-regulation	3	3
DNA Repair Up-regulation	2	3
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	2	3
Insulin-releasing	2	3
NF-E2-Related Factor-2 (Nrf2) Modulator	3	3
Adiponectin Down-Regulation	1	2
Androgen Antagonists	1	2
Anti-Glycation Agents	1	2
Anti-Ulcer Agents	1	2
Anticonvulsants	1	2
Antidepressive Agents	1	2
Appetite Depressants	1	2
Brain-derived neurotrophic factor modulator	1	2
Cyclooxygenase Inhibitors	1	2
Enzyme Activators	1	2
Fertility Agents: Male	1	2
Immunomodulatory: Th17 downregulation	1	2
Immunostimulatory	1	2
Interferon Gamma Reducer	1	2
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	1	2
Matrix Metalloproteinases Inhibitors	1	2
Osteogenic	1	2
Phase I Detoxification Enzyme Inducer	1	2
Phase II Detoxification Enzyme Inducer	1	2
Proteasome Inhibitors	1	2
Radioprotective	1	2
Radiosensitizer	2	2
SIRT1 Activator	1	2
STAT3 Inhibitor	2	2
Transforming growth factor beta (TGF-β) upregulation	1	2
anti-inflammatory	1	2
Acetylcholinesterase Inhibitor	1	1
Anti-Allergic Agents	1	1
Anti-Androgen	1	1
Anti-Infective Agents	1	1
Antioxidant	1	1
Antiparasitic Agents	1	1
Cyclin D1 Down-Regulation	1	1
Cyclin-dependent kinase inhibitor: P16INK4	1	1
Estradiol Antagonists	1	1
Glutathione S-transferase Inhibitor	1	1
Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor	1	1
Interleukin-10 downregulation	1	1
Neurogenesis	1	1
P16 Activation	1	1
P21 Activation	1	1
Phosphodiesterase Inhibitors	1	1
Photoprotective	1	1
Quorum Sensing Inhibition	1	1
Regenerative	1	1
Survivin Down-Regulation	1	1
Telomerase Inhibitor	1	1
Transforming growth factor beta (TGF-β) inhibitor	1	1
Vasodilator Agents	1	1
Vitamin D Receptor (VDR) Modulator	1	1

[+]

CoQ10 intake for 12 weeks in PCOS women significantly improved gene expression of LDLR, PPAR-γ, IL-1, IL-8 and TNF-α.Sep 25, 2017

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Pubmed Data : Gynecol Endocrinol. 2017 Sep 26:1-6. Epub 2017 Sep 26. PMID: 28949260

Article Published Date : Sep 25, 2017

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10

Diseases : Polycystic Ovary Syndrome

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Gene Expression Regulation

[+]

Delta9-tetrahydrocannabinol administration led to the inhibition of the VEGF Pathway in Two Patients with Glioblastoma Multiforme.Aug 14, 2004

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Pubmed Data : Epigenetics. 2014 Dec 2 ;9(12):1557-69. PMID: 25484259

Article Published Date : Dec 01, 2014

Study Type : Human Study

Additional Links

Therapeutic Actions : Exercise: Endurance

Pharmacological Actions : Anti Inflammatory

Additional Keywords : DNA Methylation, Epigenetic Modification, Gene Expression Regulation

[+]

Fish oil supplementation for 6 weeks in women with gestational diabetes significantly improved gene expression of PPAR-γ, IL-1, and TNF-α.Jan 30, 2018

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Pubmed Data : Nutrients. 2018 Jan 31 ;10(2). Epub 2018 Jan 31. PMID: 29385062

Article Published Date : Jan 30, 2018

Study Type : Human Study

Additional Links

Substances : Fish Oil

Diseases : Diabetes: Gestational, Gestational Diabetes

Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Gene Expression Regulation

[+]

Ginger can improve rheumatoid arthritis by decreasing disease manifestations in patients.May 24, 2019

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Pubmed Data : Gene. 2019 May 25 ;698:179-185. Epub 2019 Mar 4. PMID: 30844477

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2021 Feb 17 ;11(1):3972. Epub 2021 Feb 17. PMID: 33597583

Article Published Date : Feb 16, 2021

Study Type : Human Study

Additional Links

Substances : Lactobacillus plantarum

Diseases : Coronary Artery Disease, Endothelial Dysfunction

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-12 downregulation, Interleukin-8 downregulation

Additional Keywords : Gene Expression Regulation

[+]

Lactobacillus rhamnosus SP1 normalises skin expression of genes implicated in insulin signalling and improves adult acne.Nov 29, 2016

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Pubmed Data : Benef Microbes. 2016 Nov 30 ;7(5):625-630. Epub 2016 Sep 6. PMID: 27596801

Article Published Date : Nov 29, 2016

Study Type : Human Study

Additional Links

Diseases : Acne

Additional Keywords : Gene Expression Regulation

[+]

Magnesium and zinc co-supplementation for 12 weeks among women with PCOS had beneficial effects on inflammation and oxidative stress. Nov 09, 2017

Sudarshan Kriya practice may exert effects on immunity, aging, cell death, and stress regulation through transcriptional regulation.Jan 31, 2008

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Pubmed Data : J Psychosom Res. 2008 Feb ;64(2):213-8. PMID: 18222135

Article Published Date : Jan 31, 2008

Study Type : Human Study

Additional Links

Diseases : Aging, DNA damage, Oxidative Stress

Therapeutic Actions : Yogic Technique: Sudarshan kriya

Pharmacological Actions : Anti-Apoptotic, Antioxidants

Additional Keywords : Gene Expression Regulation

[+]

Sulforaphane treatment resulted in a significant reduction in specific airway resistance and also increased small airway luminal area.Dec 31, 2014

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Pubmed Data : Respir Res. 2015 ;16:106. Epub 2015 Sep 15. PMID: 26369337

The median survival time of patients in the deuterium depleted water consuming group was 2-4 times longer than it is generally observed in lung cancer patients.Dec 31, 2012

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[+]

Berberine can significantly inhibit the activity of N-acetyltransferase in human lung cancer cell line A549.May 31, 2014

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Pubmed Data : J Tradit Chin Med. 2014 Jun ;34(3):302-8. PMID: 24992757

Article Published Date : May 31, 2014

Study Type : Human In Vitro

Additional Links

Substances : Berberine

Diseases : Lung Cancer

Pharmacological Actions : Antineoplastic Agents, Enzyme Inhibitors, MicroRNA modulator

Additional Keywords : Chinese Herbs, Gene Expression Regulation

[+]

Bisdemethoxycurcumin induced changes in gene expression that may reveal cytotoxic information on the genetic level.Jan 10, 2015

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Pubmed Data : In Vivo. 2015 11-12;29(6):711-728. PMID: 26546528

verticillin A from Verticillium-infected wild mushrooms as a potent anti-cancer agent that effectively suppresses 5-FU-resistant human colon cancer cells. Aug 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Genom Data. 2015 Sep 1 ;5:189-191. PMID: 26309812

Article Published Date : Aug 31, 2015

Study Type : Human In Vitro

Additional Links

Substances : Mushrooms: All

Diseases : Colon Cancer

Pharmacological Actions : Apoptotic, Cell cycle arrest, Chemotherapeutic

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Epigenetic Modification In Cancer, Gene Expression Regulation

[+]

Vitamin C modulated the immune system.Mar 22, 2017

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Pubmed Data : BMC Genomics. 2017 Mar 23 ;18(1):252. Epub 2017 Mar 23. PMID: 28335738

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Gene Expression Regulation

[+]

Achillea Millefolium hydro alcoholic extract protects pancreatic cells.Dec 31, 2013

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Pubmed Data : Lipids. 2016 Aug 16. Epub 2016 Aug 16. PMID: 27531126

Article Published Date : Aug 15, 2016

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Hypolipidemic

Additional Keywords : Gene Expression Regulation

[+]

Alternating consumption of β-glucan and quercetin reduces mortality in mice with colorectal cancer.Sep 30, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Food Sci Nutr. 2019 Oct ;7(10):3273-3285. Epub 2019 Sep 4. PMID: 31660141

Article Published Date : Sep 30, 2019

Study Type : Animal Study

Additional Links

Substances : Beta-glucan, Quercetin

Diseases : Cancer Mortality, Colorectal Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Chemotherapeutic, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Gene Expression Regulation

[+]

Ameliorative effects of high intensity interval training and Lactobacillus rhamnosus GG Protect against tetracycline-induced fatty liver.Dec 31, 2021

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Pubmed Data : EXCLI J. 2022 ;21:991-1006. Epub 2022 Jul 21. PMID: 36110559

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Lactobacillus rhamnosus GG

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Therapeutic Actions : Exercise

Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor

Additional Keywords : Gene Expression Regulation

[+]

An antioxidant-rich extract of seaweed polyphenols combined with current PC treatment modalities may inhibit tumor relapse by targeting therapy-orchestrated autophagy in residual cells.Dec 31, 2014

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Pubmed Data : Cureus. 2023 Dec ;15(12):e51088. Epub 2023 Dec 25. PMID: 38274944

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Pubmed Data : World J Gastroenterol. 2015 Sep 21 ;21(35):10091-103. PMID: 26401074

Article Published Date : Sep 20, 2015

Study Type : Animal Study

Additional Links

Substances : Broccoli Sprouts

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective, Phase I Detoxification Enzyme Inducer, Phase II Detoxification Enzyme Inducer

Additional Keywords : Gene Expression Regulation, Plant Extracts

Problem Substances : Acetaminophen

[+]

C. spinosa has the potential to down regulate inflammation-involved genes in Alzheimer's disease.Oct 24, 2016

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Pubmed Data : Nutr Neurosci. 2016 Oct 25:1-8. Epub 2016 Aug 25. PMID: 27778760

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View the Evidence: 621 Abstracts with Gene Expression Regulation Research

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1,25-dihydroxyvitamin D3 induces stable and reproducible therapeutic tolerogenic dendritic cells with specific epigenetic modifications.Dec 31, 2020

Acute effects of the consumption of Passiflora setacea juice on metabolic risk factors and gene expression profile in humans.Apr 15, 2020

Aerobic exercise-training down-regulated pro-inflammatory genes, but up-regulated anti-inflammatory, neuron survival and axon growth-related genes.Aug 31, 2015

B12 supplementation influences regulation of several metabolically important Type 2 diabetes-associated genes through methylation of miR21.Nov 13, 2017

Brain education-based meditation helps lower LDL cholesterol level and the inflammatory gene expression in patients with hypertension or T2D.Apr 30, 2019

Broccoli sprout homogenate is safe in stable SCD patients and may induce changes in gene expression levels.Dec 31, 2015

Chlorella ingestion may be useful in preventing or ameliorating the course of type 2 diabetes development.May 31, 2015

Concurrent alteration in inflammatory biomarker gene expression and oxidative stress: how aerobic training and vitamin D improve T2DM.Jun 21, 2022

CoQ10 intake for 12 weeks in PCOS women significantly improved gene expression of LDLR, PPAR-γ, IL-1, IL-8 and TNF-α.Sep 25, 2017

Delta9-tetrahydrocannabinol administration led to the inhibition of the VEGF Pathway in Two Patients with Glioblastoma Multiforme.Aug 14, 2004

Diospyros peregrina fruit preparation mediated immunomodulation of lymphocytes isolated from the blood of breast cancer patients.Dec 31, 2020

Effects of Sudarshan Kriya yoga and advanced meditation program on benetic expression of pro-inflammatory and antioxidants genes.Jun 30, 2023

Endurance training positively affects thousands of DNA methylation sites and genes which leads to improvement in muscle function and health.Dec 01, 2014

Fish oil supplementation for 6 weeks in women with gestational diabetes significantly improved gene expression of PPAR-γ, IL-1, and TNF-α.Jan 30, 2018

Ginger can improve rheumatoid arthritis by decreasing disease manifestations in patients.May 24, 2019

Indole-3-carbinol could modulate the gene expression involved in wound healing in systemic lupus erythematosus cases and healthy controls.Jun 30, 2020

Lactobacillus gasseri CP2305 administration is a potential candidate therapeutic option for patients with IBS.Dec 31, 2016

Lactobacillus GG is associated with mucin genes expressions in type 2 diabetes mellitus.Jul 31, 2023

Lactobacillus plantarum 299v probiotic supplementation in men with stable coronary artery disease suppresses systemic inflammation.Feb 16, 2021

Lactobacillus rhamnosus SP1 normalises skin expression of genes implicated in insulin signalling and improves adult acne.Nov 29, 2016

Magnesium and zinc co-supplementation for 12 weeks among women with PCOS had beneficial effects on inflammation and oxidative stress. Nov 09, 2017

Maternal gene expression changes during pregnancy and that these changes are related to vitamin D levels.Dec 31, 2015

Metabolised pycnogenol induces apoptosis in human fibrosarcoma cells.Mar 31, 2015

Mindfulness meditation reduces intraocular pressure, lowers stress biomarkers and modulates gene expression in glaucoma.Nov 30, 2018

Omega-3 fatty acids supplementation for 12 weeks in PCOS women significantly improved gene expression of PPAR-γ and LDLR.Feb 23, 2017

Omega-3 fatty acids supplementation for 6 weeks to women with gestational diabetes mellitus had beneficial effects.Jan 05, 2020

Oral Shilajit supplementation in adult overweight/class I obese human subjects promoted skeletal muscle adaptation.Jun 30, 2016

Prolonged periods of sedentary behavior are associated with significantly lower BRCA1 mRNA expression.Nov 01, 2015

Rapid changes in histone deacetylases and inflammatory gene expression in expert meditatorsJan 31, 2014

Spa therapy induces clinical improvement and protein changes in patients with chronic back pain.Oct 23, 2019

Sudarshan Kriya practice may exert effects on immunity, aging, cell death, and stress regulation through transcriptional regulation.Jan 31, 2008

Sulforaphane treatment resulted in a significant reduction in specific airway resistance and also increased small airway luminal area.Dec 31, 2014

Suppression of Growth Differentiation Factor 15 Gene Expression by Curcumin in Patients with Beta-Thalassemia Intermedia.Dec 31, 2023

Suppression of pro-inflammatory and pro-survival biomarkers in oral cancer patients consuming a black raspberry phytochemical-rich troche.Dec 22, 2015

Taking myo-inositol by women with PCOS had beneficial effects on glycemic control, triglycerides and VLDL-cholesterol levels, and gene expression of PPAR-γ.Jan 03, 2019

The bioactivity of garlic is multifaceted and includes activation of genes related to immunity, apoptosis, and xenobiotic metabolism in humans and Mono Mac 6 cells.Sep 29, 2015

The effect of genistein on lipid levels and LDLR, LXRα and ABCG1 expression in postmenopausal women with hyperlipidemia.Dec 31, 2018

The median survival time of patients in the deuterium depleted water consuming group was 2-4 times longer than it is generally observed in lung cancer patients.Dec 31, 2012

Third-trimester high-dose vitD3 supplementation in healthy pregnant women had balanced effects on biomarkers of cord blood Th1 and Th2 responses.Dec 31, 2015

Transcriptomic profile of whole blood cells from elderly subjects fed probiotic bacteria Lactobacillus rhamnosus GG.Dec 31, 2015

ubiquinol decreases monocytic expression and DNA methylation of the pro-inflammatory CXCL2 gene in humans.Sep 30, 2012

Upregulation of vitamin D-related genes in schizophrenic patients.Dec 31, 2017

Vitamin C boosts DNA demethylation in TET2 germline mutation carriers.Jan 13, 2023

Vitamin C supplementation has beneficial effects for the male partners of couples with recurrent pregnancy loss could lead to improved pregnancy outcomes.Feb 29, 2020

Vitamin D reduces clinical and metabolic symptoms in end-stage renal disease.May 30, 2022

Vitamin D supplementation may have a beneficial role in ulcerative colitis patients.Jun 30, 2016

Yogic practices have rapid effects at the molecular level in circulating immune cells.Dec 31, 2012

Alpha-lipoic acid could be a therapeutic agent because of its inhibitory effects on ROS production, inflammation, and adipose tissue expansionDec 31, 2015

Amurensin G augmented the cytotoxic and apoptotic effects of TRAIL in TRAIL resistant leukemic cells.Jul 31, 2012

Amurensin G had significant antiangiogenic and antitumor growth effects in tamoxifen resistant breast cancer.Sep 30, 2012

Amurensin G. was a potent SIRT1 Inhibitor which led to the down regulation of multidrug resistance.Oct 31, 2010

Berberine can significantly inhibit the activity of N-acetyltransferase in human lung cancer cell line A549.May 31, 2014

Bisdemethoxycurcumin induced changes in gene expression that may reveal cytotoxic information on the genetic level.Jan 10, 2015

In utero bisphenol A exposure is linked with sex specific changes in the transcriptome and methylome of human amniocytes.Sep 18, 2019

LED irradiation promoted elastin gene expression more in elderly than in younger adults.Mar 31, 2016

Malaysian and Brazilian red propolis show potential to assist in wound healing.Dec 31, 2014

Psoralea corylifolia induces apoptosis and autophagy and alteres genes expression assayed by cDNA microarray in human prostate cancer PC-3 cells.Jun 30, 2018

Sulforaphane regulates xenobiotic metabolism phase II and III enzymes differently in colorectal cancer and untransformed epithelial colon cells.Oct 31, 2016

Taurine ameliorates particulate matter-induced emphysema by switching on mitochondrial NADH dehydrogenase genes.Oct 24, 2017

The proapoptotic effect of cannabinoids on tumor cells is mediated by a ceramide dependent upregulation of the stress protein p8.Mar 31, 2006

These results provide important new data for ellagic acid in anti-colorectal carcinoma research.Jan 31, 2017

Thymoquinone-rich fractions of Nigella sativa could be an alternative to combat oxidative stress insults in neurodegenerative diseases.Dec 31, 2015

verticillin A from Verticillium-infected wild mushrooms as a potent anti-cancer agent that effectively suppresses 5-FU-resistant human colon cancer cells. Aug 31, 2015

Vitamin C modulated the immune system.Mar 22, 2017

Albiflorin ameliorates obesity by inducing thermogenic genes.Dec 31, 2016

In vitro and in vivo anti-lung cancer activity of emodin: A RNA-seq transcriptome analysis.Sep 20, 2022

Supplemented with natural herbo-mineral Shilajit shows induction of microvascular and extracellular matrix mechanisms.Jul 31, 2019

10% pectin supplementation for one month in adult rats decreases body-fat content and ameliorates age-related insulin and leptin resistance.Jul 21, 2015

4D-DIA quantitative proteomics revealed the core mechanism of diabetic retinopathy after berberine treatment.Aug 30, 2023

5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.Dec 31, 2015

A cucurbitane type triterpenoid compound from Momordica charantia alleviated diabetic metabolic symptoms in alloxan induced diabetic mice.Oct 31, 2016

A hot water extract from wasabi leaves induces mild suppression of obesity in a high-fat diet induced mice.Jul 31, 2013

Gene Expression Regulation

View the Evidence:
621 Abstracts with Gene Expression Regulation Research