Metabolites

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3 Problem Substances Researched for Metabolites
NameACCKFocus
Acetaminophen11Locked
Bisphenol A 11Locked
Paracetamol11Locked
34 Diseases Researched for Metabolites
NameACCKFocus
Colorectal Cancer313Locked
Dysbiosis110Locked
Dysbiosis: Bifidobacteria Deficiency110Locked
Myelodysplastic Syndrome110Locked
Myelodysplastic Syndromes110Locked
Colon Cancer69Locked
Breast Cancer45Locked
Cancers: All34Locked
Lung Cancer34Locked
Oxidative Stress34Locked
Carcinoma: Non-Small-Cell Lung12Locked
Colitis12Locked
Colon Cancer: Prevention12Locked
Colorectal Cancer: Prevention 12Locked
Endometriosis12Locked
Hepatitis C12Locked
Lipid Peroxidation12Locked
Acetaminophen (Tylenol) Toxicity 11Locked
Alzheimer's Disease11Locked
Anxiety Disorders11Locked
Bisphenol Toxicity11Locked
Cancer Metastasis11Locked
Cardiovascular Disease: Prevention11Locked
Cardiovascular Diseases11Locked
Cervical Cancer11Locked
Chemically-Induced Liver Damage11Locked
Depression11Locked
Inflammation11Locked
Influenza A11Locked
Liver Cancer11Locked
Melanoma11Locked
Neurological Conditions11Locked
Ovarian Cancer11Locked
Thyroid Cancer11Locked
42 Substances Researched for Metabolites
NameACCKFocus
Black Raspberry314Locked
Vitamin A414Locked
Urolithin A 212Locked
Polyphenols211Locked
Anthocyanins110Locked
Pomegranate110Locked
Vitamin E: alpha tocopherol110Locked
Lichens66Locked
Curcumin35Locked
Nobiletin 23Locked
Vitamin C23Locked
Caffeic Acid12Locked
Curcuminoids22Locked
EGCG (Epigallocatechin gallate)12Locked
Ellagic Acid12Locked
Flavonoids22Locked
Gallic Acid12Locked
Ginsenosides12Locked
Green Tea12Locked
Isoliquiritigenin12Locked
Melatonin12Locked
Nigella sativa (aka Black Seed)12Locked
Resveratrol12Locked
Rosmarinic acid12Locked
Tetrahydrocurcumin22Locked
Vitamin D12Locked
6-Shogaol11Locked
Berries: All11Locked
Corn Silk11Locked
Flax Straw11Locked
Ginger11Locked
Gingerol 11Locked
Hydroxytyrosol11Locked
Lion's Mane (Hericium Erinaceus)11Locked
Nuts11Locked
Oleuropein11Locked
Olive11Locked
Polyunsaturated Fatty Acids (PUFAs)11Locked
Prebiotics11Locked
Rose 11Locked
Sulforaphane11Locked
Verbascoside11Locked
29 Pharmacological Actions Researched for Metabolites
NameACCKFocus
Antiproliferative 912Locked
Gastrointestinal Agents211Locked
Anticarcinogenic Agents59Locked
Apoptotic78Locked
Anti-Inflammatory Agents46Locked
Chemopreventive46Locked
Antioxidants34Locked
Immunomodulatory24Locked
Neuroprotective Agents44Locked
Antiviral Agents23Locked
Cardioprotective33Locked
Anti-metastatic22Locked
Antineoplastic Agents22Locked
Cell cycle arrest12Locked
Chemosensitizer12Locked
Enzyme Inhibitors12Locked
Hepatoprotective22Locked
Immunostimulatory12Locked
Anti-Apoptotic11Locked
Antihypertensive Agents11Locked
Bcl-2 protein down-regulation11Locked
Caspase-3 Activation11Locked
Caspase-8 activation11Locked
Caspase-9 Activation11Locked
Chemotherapeutic11Locked
Gastroprotective11Locked
Hypolipidemic11Locked
Neurogenesis11Locked
Topoisomerase II Inhibitor11Locked

View the Evidence:
37 Abstracts with Metabolites Research

[+]

High levels of Bifidobacteria are associated with increased levels of anthocyanin microbial metabolites.Jul 31, 2014

Pubmed Data : Food Funct. 2014 Aug ;5(8):1932-8. PMID: 24958563
Article Published Date : Jul 31, 2014
Study Type : Human Study
Additional Links
Substances : Anthocyanins, Polyphenols
Diseases : Dysbiosis: Bifidobacteria Deficiency
Additional Keywords : Metabolites, Microbiota
[+]

In UA producers, the genera Butyrivibrio, Enterobacter, Escherichia, Lactobacillus, Prevotella, Serratia and Veillonella were increased and Collinsella decreased significantly at week 4 compared to baseline.Jul 19, 2015

Pubmed Data : Food Funct. 2015 Jul 20. Epub 2015 Jul 20. PMID: 26189645
Article Published Date : Jul 19, 2015
Study Type : Human Study
Additional Links
Substances : Pomegranate, Urolithin A
Diseases : Dysbiosis
Pharmacological Actions : Gastrointestinal Agents
Additional Keywords : Metabolites, Microbiota
[+]

This study supports the hypothesis that black raspberries might be beneficial to colorectal cancer patients through the regulation of multiple metabolites.Jul 31, 2015

Pubmed Data : Cancer Prev Res (Phila). 2015 Aug ;8(8):743-50. Epub 2015 Jun 8. PMID: 26054356
Article Published Date : Jul 31, 2015
Study Type : Human Study
Additional Links
Substances : Black Raspberry
Diseases : Colorectal Cancer
Additional Keywords : Metabolites
[+]

Vitamin E and a synthetic analogue of vitamin A improve the treatment outcome of myelodysplastic syndrome. Dec 01, 1990

Pubmed Data : Am J Med. 1990 Dec;89(6):739-47. PMID: 2252043
Article Published Date : Dec 01, 1990
Study Type : Human Study
Additional Links
Substances : Vitamin A, Vitamin E: alpha tocopherol
Diseases : Myelodysplastic Syndrome, Myelodysplastic Syndromes
Additional Keywords : Metabolites
[+]

A major metabolite of EGCG increased the activity of CD4(+) T cells and enhanced the cytotoxic activity of NK cells in vivo.May 10, 2016

Pubmed Data : J Agric Food Chem. 2016 May 11 ;64(18):3591-7. Epub 2016 May 2. PMID: 27112424
Article Published Date : May 10, 2016
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Green Tea
Pharmacological Actions : Immunostimulatory
Additional Keywords : Metabolites
[+]

Administration of melatonin, retinoic acid and Nigella sativa reduced the carcinogenic effects of DMBA.Nov 30, 2005

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Exp Pathol. 2005 Dec ;86(6):383-96. PMID: 16309544
Article Published Date : Nov 30, 2005
Study Type : Animal Study
Additional Links
Substances : Melatonin, Nigella sativa (aka Black Seed), Vitamin A
Diseases : Breast Cancer, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Metabolites, Phytotherapy, Plant Extracts
[+]

BRB extracts and their physiologically relevant metabolites contain phytochemicals that affect immune processes relevant to carcinogenesis and immunotherapy.Aug 31, 2014

Pubmed Data : Cancer Immunol Immunother. 2014 Sep ;63(9):889-900. Epub 2014 Jun 4. PMID: 24893859
Article Published Date : Aug 31, 2014
Study Type : Animal Study
Additional Links
Substances : Black Raspberry
Diseases : Cancers: All
Pharmacological Actions : Anticarcinogenic Agents, Immunomodulatory
Additional Keywords : Metabolites, Plant Extracts
[+]

Co-administration of antioxidant significantly increased plasma level of curcumin in animal models.Nov 25, 2015

Pubmed Data : Mol Nutr Food Res. 2015 Nov 26. Epub 2015 Nov 26. PMID: 26608515
Article Published Date : Nov 25, 2015
Study Type : Animal Study
Additional Links
Substances : Caffeic Acid, Curcumin, Gallic Acid, Rosmarinic acid, Vitamin C
Diseases : Colon Cancer
Pharmacological Actions : Antioxidants, Antiproliferative
Additional Keywords : Increased Bioavailability, Metabolites
[+]

Co-treatments with Uro-A decreased IC50 values for both 5-FU and 5'DFUR and additionally arrested the cell cycle at the G2/M phase.Apr 30, 2015

Pubmed Data : Food Funct. 2015 May ;6(5):1460-9. PMID: 25857357
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid, Urolithin A
Diseases : Colon Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Cell cycle arrest, Chemosensitizer
Additional Keywords : Drug: 5-flourouracil, Metabolites, Microbiota
[+]

Curcumin alters the phase II distribution of resveratrol through inhibiting efflux transporters including MRP2 and BCRP.Oct 25, 2015

Pubmed Data : Pharm Res. 2015 Oct 26. Epub 2015 Oct 26. PMID: 26502886
Article Published Date : Oct 25, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin, Resveratrol
Additional Keywords : Increased Bioavailability, Metabolites
[+]

Freeze-dried black raspberries produced beneficial effects against colonic adenoma development in mice and modulated multiple metabolic pathways.Aug 04, 2015

Pubmed Data : Carcinogenesis. 2015 Aug 5. Epub 2015 Aug 5. PMID: 26246425
Article Published Date : Aug 04, 2015
Study Type : Animal Study
Additional Links
Substances : Black Raspberry
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Enzyme Inhibitors
Additional Keywords : Metabolites
[+]

Oral administration of nobiletin significantly inhibited colitis-associated colon carcinogenesis in mice.Sep 09, 2015

Pubmed Data : Mol Nutr Food Res. 2015 Sep 10. Epub 2015 Sep 10. PMID: 26445322
Article Published Date : Sep 09, 2015
Study Type : Animal Study
Additional Links
Substances : Nobiletin
Diseases : Colitis, Colon Cancer, Colon Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antiproliferative , Apoptotic, Chemopreventive
Additional Keywords : Metabolites
[+]

Suppression of lung cancer progression by isoliquiritigenin through its metabolite 2, 4, 2', 4'-Tetrahydroxychalcone.Oct 02, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Clin Cancer Res. 2018 Oct 3 ;37(1):243. Epub 2018 Oct 3. PMID: 30285892
Article Published Date : Oct 02, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Isoliquiritigenin
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Metabolites, Plant Extracts
[+]

This result provides a scientific basis for potential therapeutic strategies to treat endometriosis by protopanaxadiol a metabolite of ginsenoside.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Dis. 2018 05 1 ;9(5):574. Epub 2018 May 1. PMID: 29760378
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Endometriosis
Pharmacological Actions : Immunomodulatory
Additional Keywords : Metabolites
[+]

Vitamin D metabolites all possess modest to strong anti- hepatitis C virus activity.Oct 05, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Virol Antivir Res. 2014 Oct 6 ;3(3). PMID: 26594646
Article Published Date : Oct 05, 2014
Study Type : Animal Study
Additional Links
Substances : Vitamin D
Diseases : Hepatitis C
Pharmacological Actions : Antiviral Agents
Additional Keywords : Gene Expression Regulation, Metabolites
[+]

Agathisflavone enhances retinoic acid-induced neurogenesis and its receptors α and β in pluripotent stem cells.Sep 30, 2011

Pubmed Data : Stem Cells Dev. 2011 Oct ;20(10):1711-21. Epub 2011 Mar 18. PMID: 21281018
Article Published Date : Sep 30, 2011
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Vitamin A
Pharmacological Actions : Anti-Apoptotic, Neurogenesis, Neuroprotective Agents
Additional Keywords : Metabolites
[+]

All-trans retinoic acid improves the iodine uptake of thyroid cancer cells.Feb 22, 2016

Pubmed Data : Zhonghua Yi Xue Za Zhi. 2016 Feb 23 ;96(7):553-558. PMID: 26902198
Article Published Date : Feb 22, 2016
Study Type : In Vitro Study
Additional Links
Substances : Vitamin A
Diseases : Thyroid Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative
Additional Keywords : Metabolites
[+]

Anticancer potential of lichens' secondary metabolites.Jan 04, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2020 Jan 5 ;10(1). Epub 2020 Jan 5. PMID: 31948092
Article Published Date : Jan 04, 2020
Study Type : Review
Additional Links
Substances : Lichens
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Metabolites
[+]

Curcumin and its metabolites could inhibit type A influenza virus infection.Oct 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : FEBS J. 2013 Nov ;280(22):5829-40. Epub 2013 Sep 23. PMID: 24034558
Article Published Date : Oct 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Curcuminoids, Tetrahydrocurcumin
Diseases : Influenza A
Pharmacological Actions : Antiviral Agents
Additional Keywords : Metabolites, Petasiphenol
[+]

Discovery of novel ascorbic acid derivatives and other metabolites in fruit of Rosa roxburghii.Nov 01, 2022

Pubmed Data : Food Chem. 2022 Nov 2 ;405(Pt A):134807. Epub 2022 Nov 2. PMID: 36370576
Article Published Date : Nov 01, 2022
Study Type : In Vitro Study
Additional Links
Substances : Rose , Vitamin C
Additional Keywords : Metabolites
[+]

Diverse metabolites from corn silk with anti-Aβ1-42 aggregation activity.Sep 30, 2019

Pubmed Data : Fitoterapia. 2019 Oct ;138:104356. Epub 2019 Sep 11. PMID: 31520649
Article Published Date : Sep 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Corn Silk
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Metabolites
[+]

Flax straw metabolites effectively induced growth inhibition and apoptosis in human breast adenocarcinoma cells. Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2016 ;7:282. Epub 2016 Aug 31. PMID: 27630565
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Flax Straw
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Gene Expression Regulation, Metabolites
[+]

Lichen metabolites showed various cytotoxic effects in a concentration-dependent manner against cancer cells. Feb 28, 2013

Pubmed Data : Phytother Res. 2013 Mar ;27(3):431-7. Epub 2012 May 25. PMID: 22628260
Article Published Date : Feb 28, 2013
Study Type : In Vitro Study
Additional Links
Substances : Lichens
Diseases : Breast Cancer, Cervical Cancer, Colon Cancer, Oxidative Stress
Pharmacological Actions : Antioxidants, Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation
Additional Keywords : Dose Response, Metabolites
[+]

Lichen secondary metabolite physciosporin decreases the stemness potential of colorectal cancer cells.Nov 27, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2019 Nov 28 ;9(12). Epub 2019 Nov 28. PMID: 31795147
Article Published Date : Nov 27, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lichens
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Chemotherapeutic
Additional Keywords : Cancer Stem Cells, Metabolites
[+]

Lichen secondary metabolites are responsible for induction of apoptosis in HT-29 and A2780 human cancer cell lines.Mar 31, 2012

Pubmed Data : Toxicol In Vitro. 2012 Apr ;26(3):462-8. Epub 2012 Jan 21. PMID: 22285236
Article Published Date : Mar 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Lichens
Diseases : Colon Cancer, Ovarian Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Metabolites
[+]

Metabolites of [6]-shogoal can account for the bioactivity of the parent compound, and specifically triggers molecular pathways responsible for cancer cell death in a similar fashion.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2013 ;8(1):e54677. Epub 2013 Jan 30. PMID: 23382939
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol, Ginger, Gingerol
Diseases : Colon Cancer, Lung Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Chemopreventive
Additional Keywords : Metabolites
[+]

Non-bioaccessible material of nuts provides substrates for the human gut microbiota and the formation of new bioactive metabolites.May 24, 2016

Pubmed Data : Crit Rev Food Sci Nutr. 2016 May 25:0. Epub 2016 May 25. PMID: 27224877
Article Published Date : May 24, 2016
Study Type : Review
Additional Links
Substances : Nuts, Prebiotics
Additional Keywords : Metabolites, Microbiota
[+]

Olive metabolites appear to act as topoisomerase II poisons in complex formulations intended for human dietary consumption.Jun 30, 2015

Pubmed Data : Biochemistry. 2015 Jul 1. Epub 2015 Jul 1. PMID: 26132160
Article Published Date : Jun 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Hydroxytyrosol, Oleuropein, Olive, Verbascoside
Pharmacological Actions : Topoisomerase II Inhibitor
Additional Keywords : Metabolites
[+]

Omega-3 metabolites may contribute to the beneficial effects against CVDs that are attributed to omega-3 PUFAs.Sep 06, 2015

Pubmed Data : J Cardiol. 2015 Sep 7. Epub 2015 Sep 7. PMID: 26359712
Article Published Date : Sep 06, 2015
Study Type : Review
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Cardiovascular Disease: Prevention, Cardiovascular Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective
Additional Keywords : Metabolites
[+]

Physciosporin inhibits lung cancer cell motility through novel mechanisms of action.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(9):e0137889. Epub 2015 Sep 15. PMID: 26371759
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Lichens
Diseases : Cancer Metastasis, Lung Cancer
Pharmacological Actions : Anti-metastatic, Antineoplastic Agents
Additional Keywords : Metabolites, Plant Extracts
[+]

Repeated exposure to a metabolite of bisphenol A aggressively stimulated breast cancer cell growth.Dec 13, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Pharmacol. 2018 Dec 14. Epub 2018 Dec 14. PMID: 30552153
Article Published Date : Dec 13, 2018
Study Type : In Vitro Study
Additional Links
Diseases : Bisphenol Toxicity, Breast Cancer
Additional Keywords : Metabolites
Problem Substances : Bisphenol A
[+]

Secondary metabolites present in lichen could induce apoptosis in A375 melanoma cancer cell line.Dec 20, 2016

Pubmed Data : Chem Biol Interact. 2016 Dec 21 ;263:36-45. Epub 2016 Dec 21. PMID: 28012710
Article Published Date : Dec 20, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lichens
Diseases : Melanoma
Pharmacological Actions : Apoptotic
Additional Keywords : Dose Response, Metabolites
[+]

Tetrahydrocurcumin and octahydrocurcumin possess superior hepatic-protective effect against acetaminophen-induced liver injury.Dec 31, 2018

Pubmed Data : Food Chem Toxicol. 2019 Jan ;123:349-362. Epub 2018 Nov 10. PMID: 30423402
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Curcuminoids, Tetrahydrocurcumin
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Oxidative Stress
Pharmacological Actions : Hepatoprotective
Additional Keywords : Metabolites
Problem Substances : Acetaminophen, Paracetamol
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The in vitro and in vivo bioactivities of these polyphenol metabolites and catabolites are assessed.Sep 30, 2010

Pubmed Data : Br J Nutr. 2010 Oct ;104 Suppl 3:S67-90. PMID: 20955651
Article Published Date : Sep 30, 2010
Study Type : Review
Additional Links
Substances : Berries: All, Flavonoids, Polyphenols
Pharmacological Actions : Gastrointestinal Agents, Gastroprotective
Additional Keywords : Metabolites, Plant Extracts
[+]

The metabolites of Nobiletin may exhibit stronger beneficial effects on diseases pathogenesis.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2016 ;2016:2918796. Epub 2016 Sep 27. PMID: 27761146
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Substances : Nobiletin
Diseases : Cancers: All, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Neuroprotective Agents
Additional Keywords : Metabolites
[+]

The reported health-promoting properties of the mushroom fruit bodies, mycelia, and bioactive pure compounds in lion's mane.Aug 04, 2015

Pubmed Data : J Agric Food Chem. 2015 Aug 5. Epub 2015 Aug 5. PMID: 26244378
Article Published Date : Aug 04, 2015
Study Type : Review
Additional Links
Substances : Lion's Mane (Hericium Erinaceus)
Diseases : Anxiety Disorders, Depression, Neurological Conditions
Pharmacological Actions : Anticarcinogenic Agents, Antihypertensive Agents, Cardioprotective, Hepatoprotective, Hypolipidemic, Neuroprotective Agents
Additional Keywords : Metabolites
[+]

This study provides appealing evidence that the principal metabolites of sulforaphane retain the anticancer activity of the parent compound in HepG2 cells.May 08, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 May 9 ;10(5). Epub 2018 May 9. PMID: 29747418
Article Published Date : May 08, 2018
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Liver Cancer
Pharmacological Actions : Chemopreventive
Additional Keywords : Metabolites

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