Natural Substance Synergy

Name	AC	CK
Aluminum Chloride	3	6
Acetaminophen	2	4
Benzo(a)pyrene	2	4
Paracetamol	2	4
Sodium Fluoride	2	4
Aflatoxin	1	2
Alloxan	1	2
Arsenite	1	2
Concanavalin A	1	2
Lead	1	2
Monosodium Glutamate (MSG)	1	2
Mycotoxin	1	2
Nicotine	1	2
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	2
Antibiotics	1	1

Name	AC	CK
Oxidative Stress	42	75
Breast Cancer	42	59
Prostate Cancer	28	34
Lung Cancer	22	31
Inflammation	20	28
Cardiovascular Diseases	7	27
Colorectal Cancer	14	24
Hypertension	4	24
Breast Cancer: Triple Negative	13	22
Colon Cancer	20	22
Diabetes Mellitus: Type 2	12	22
Hyperlipidemia	7	22
Polycystic Ovary Syndrome	3	22
Cognitive Decline/Dysfunction	7	21
Liver Cancer	15	21
Osteoarthritis: Knee	3	21
C-Reactive Protein	2	20
Headache: Migraine	2	20
Spondylitis: Ankylosing	1	20
Cancers: All	16	19
Diabetic Complications	8	18
Alzheimer's Disease	12	17
Cervical Cancer	7	17
Obesity	9	16
Oral Cancer	6	15
Atherosclerosis	3	14
Memory Disorders	3	14
Cardiovascular Disease: Prevention	2	12
Hypercholesterolemia	2	12
Metabolic Diseases	2	12
Vitamin D Deficiency	2	12
Aging Skin	2	11
Chemically-Induced Liver Damage	6	11
Hyperglycemia	4	11
Osteoarthritis	2	11
Urinary Tract Infections	2	11
Cholesterol: High	1	10
Cytomegalovirus Infections	1	10
Esophageal Cancer	1	10
Fibrosarcoma	1	10
Fibrosis	1	10
Folic Acid/Folate Deficiency	1	10
Herpes Simplex Virus Type 1	1	10
High Cholesterol	1	10
Homocysteine: Elevated	1	10
Irritable Bowel Syndrome	1	10
Melanoma	8	10
Metabolic Syndrome X	1	10
Morphine Tolerance/Dependence	1	10
Neurofibromatosis	1	10
Prostate: PSA Doubling	1	10
Prostatic Hyperplasia	1	10
Smoking Cessation: Nicotine Addiction	1	10
Lipid Peroxidation	5	9
Staphylococcus aureus infection	9	9
Brain Inflammation	4	8
Cerebral Ischemia	4	8
Diabetes: Oxidative Stress	4	8
Gastric Cancer	6	8
High Fat Diet	4	8
Malaria	5	8
Multiple Myeloma	3	8
Myocardial Infarction	4	8
Pancreatic Cancer	7	8
Parkinson's Disease	5	8
Acute Myeloid Leukemia	6	7
Escherichia coli Infections	7	7
Glioblastoma	6	7
Insulin Resistance	4	7
Neurodegenerative Diseases	5	7
Aluminum Toxicity	3	6
Candida Albicans	5	6
Diabetes Mellitus: Type 1	3	6
Dyslipidemias	3	6
Hypoglycemia	4	6
Promyelocytic leukemia	6	6
Sepsis	3	6
Ulcerative Colitis	3	6
Wound Healing	3	6
Cancers: Drug Resistant	1	5
Cancers: Multi-Drug Resistant	1	5
Head and Neck Cancer	3	5
Leukemia: Chronic myelogenous leukemia (CML)	1	5
Liver Fibrosis	3	5
Salmonella Infections	4	5
Acetaminophen (Tylenol) Toxicity	2	4
Cadmium Poisoning	2	4
Cancer Metastasis	2	4
Carcinoma: Non-Small-Cell Lung	3	4
Cholestasis	2	4
Cholesterol: Oxidation	2	4
Endothelial Dysfunction	2	4
Fluoride Toxicity	2	4
Lipopolysaccharide-Induced Toxicity	4	4
Peripheral Neuropathies	2	4
Prostate Cancer: Prevention	3	4
Pseudomonas aeruginosa	4	4
Triglycerides: Elevated	2	4
Aging	2	3
Asthma	2	3
Brain Ischemia	2	3
Chronic Pain	2	3
Colon Cancer: Prevention	2	3
Colorectal Cancer: Prevention	2	3
DNA damage	2	3
Dementia	2	3
Human Papillomavirus (HPV)	2	3
Influenza A	2	3
Leukemia: Acute promyelocytic leukemia	3	3
Listeria Infections	3	3
Lymphoma	2	3
Nonalcoholic fatty liver disease (NAFLD)	2	3
Osteoporosis	2	3
Squamous cell carcinoma	3	3
Staphylococcus aureus: Methicillin-resistant (MRSA)	3	3
Aging: Heart	1	2
Amnesia	1	2
Amyotrophic Lateral Sclerosis	1	2
Androgen-Induced Diseases	1	2
Arteriosclerosis	1	2
Avian Influenza	1	2
Bacterial Infections	1	2
Bowel Surgery	1	2
Brain Cancer	1	2
Brain Hypoxia	1	2
Breast Cancer: Chemically-Induced	2	2
Burns	1	2
Cancers	2	2
Candidiasis: Vulvovaginal	1	2
Chemotherapy and Radiation Toxicity	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Chronic Myeloid Leukemia	1	2
Depression	1	2
Depressive Disorder	1	2
Diabetes	1	2
Diabetic Neuropathy	1	2
Dry Eye Syndromes	1	2
Dysbiosis	1	2
Emesis	1	2
Epstein-Barr Virus Infections	1	2
Fructose-Induced Toxicity	1	2
Gallstones	1	2
Gout	1	2
Heart Failure	1	2
Hepatitis C	1	2
Huntington Disease	1	2
Hyperalgesia	1	2
Hyperinsulinism	1	2
Hyperuricemia	1	2
Immune Dysregulation: TH1/TH2 imbalance	1	2
Intestinal Polyps	1	2
Iron Poisoning	1	2
Lead Poisoning	1	2
Leishmaniasis	1	2
Leukemia	2	2
Leukemia: Chronic Lymphocytic Leukemia (CLL)	2	2
Liver Cancer: Prevention	1	2
Liver Cirrhosis	1	2
Liver Damage	1	2
Liver Damage: Aflatoxin-Induced	1	2
Liver Damage: Drug-Induced	1	2
Liver Disease	1	2
Malignant Melanoma	1	2
Menopausal Syndrome	1	2
Motor Neuron Disease	1	2
Multiple Sclerosis	2	2
Myelotoxicity	1	2
Nasopharyngeal Cancer	1	2
Nicotine/Tobacco Toxicity	1	2
Pulmonary Fibrosis: Bleomycin-Induced	1	2
Skin Cancer: Prevention	1	2
Sleep Disorders	1	2
Spinal Cord Injuries	1	2
Staphylococcal Infections	1	2
Staphylococcus epidermidis	2	2
Stress	1	2
Tuberculosis	1	2
Ulcers	1	2
Vomiting	1	2
Abdominal Obesity (Midsection Fat)	1	1
Acinetobacter baumannii infection	1	1
Acute T cell Leukemias	1	1
Aging: Brain	1	1
Alcoholic Liver Disease	1	1
Arthritis	1	1
Autoimmune Diseases	1	1
Bacillus Cereus infection	1	1
Brain Injury: Hippocampal Damage	1	1
Campylobacter Infections	1	1
Cancer Stem Cells	1	1
Candida Infection	1	1
Chagas Disease	1	1
Chemotherapy-Induced Toxicity: Doxorubicin	1	1
Chronic Lymphocytic Leukemia	1	1
Coronavirus Infection	1	1
Dental Implantation	1	1
Diabetic Retinopathy	1	1
Encephalomyelitis	1	1
Endometrial Cancer	1	1
Enterococcus Infections	1	1
Food Poisoning	1	1
Gastrointestinal Inflammation	1	1
Gonorrhea	1	1
Gram-Positive Bacterial Infections	1	1
Helicobacter Pylori Infection	1	1
Kidney Cancer	1	1
Klebsiella Infections	1	1
Learning disorders	1	1
Leiomyosarcoma	1	1
Leukemia: Acute myelogenous leukemia (AML)	1	1
Micrococcus luteus infections	1	1
Multi-Organ Failure	1	1
Mycobacterium tuberculosis	1	1
Neuroblastoma	1	1
Neurodevelopmental Disorders	1	1
Neurologic Disorders	1	1
Neurological Conditions	1	1
Non-Small-Cell Lung Carcinoma	1	1
Osteoclastoma	1	1
Osteopenia	1	1
Osteosarcoma	1	1
Ovarian Cancer	1	1
Periodontitis	1	1
Photooxidative Stress	1	1
Radiation	1	1
Renal Cancer	1	1
Retinal Degeneration: Light-Induced	1	1
Retinal Detachment	1	1
Rotavirus Infections	1	1
Skin Cancer	1	1
Tongue Cancer	1	1

Name	AC	CK	Focus
Radiotherapy	1	2

Name	AC	CK
Curcumin	95	193
Vitamin C	38	82
Green Tea	16	60
Quercetin	35	55
Resveratrol	34	54
Polyphenols	16	46
Turmeric	14	46
Vitamin E	19	46
EGCG (Epigallocatechin gallate)	29	42
Vitamin D	29	41
Coenzyme Q10	7	37
Frankincense	6	34
Selenium	16	32
Vitamin B-12	4	32
Piperine	18	31
Omega-3 Fatty Acids	3	30
Vitamin E: alpha tocopherol	7	28
Fish Oil	5	25
Ginkgo biloba	4	24
Catechin	14	22
Peony	2	22
Aloe Vera	2	20
Folic Acid	2	20
Lignans	2	20
Anthocyanins	7	19
Melatonin	14	18
Olive Oil	5	17
Nigella sativa (aka Black Seed)	4	16
Zinc	5	16
Hesperidin	4	15
Luteolin	10	15
Bacopa	4	14
Black Pepper	3	13
EPA (Eicosapentaenoic Acid)	3	13
Berberine	10	12
Cranberry	3	12
Mangosteen	2	12
NAC (N-acetyl-L-cysteine)	6	12
Riboflavin (Vitamin B-2)	3	12
Sulforaphane	10	12
Tocotrienol: Gamma	4	12
Beet	2	11
Cocoa	2	11
Coffee	2	11
Cyanidin 3-glucoside	2	11
Fennel	2	11
Flavonoids	9	11
Ginger	9	11
Ginsenosides	7	11
Licorice	7	11
Milk Thistle	2	11
Vitamin E: Gamma-Tocopherol	2	11
Angelica	1	10
Apples	1	10
Astragaloside	7	10
Chinese Herbal Formula: Jinye Baidu	1	10
Delphinidin	1	10
Egg	1	10
Flaxseed	1	10
Garlic	6	10
Ginseng (American)	1	10
Grapefruit	1	10
Haritaki (Terminalia chebula)	1	10
Hazelnut	1	10
Lactobacillus rhamnosus	1	10
Magnesium Sulfate	1	10
Nattokinase	1	10
Nuts: All	1	10
Phosphatidylserine	1	10
Pine Cone	1	10
Pycnogenol (Pine Bark)	1	10
Red Yeast Rice	1	10
Soup	1	10
Thymoquinone	5	10
Vitamin B-5 (Pantothenic Acid)	1	10
acetyl-11-keto-beta-boswellic acid	1	10
Ferulic acid	6	9
Fisetin	4	9
Artemisinin	6	8
Cannabidiol	4	8
Delta-tetrahydrocannabinol (THC)	4	8
Genistein	7	8
Lycopene	5	8
Silibinin	6	8
Carnosic Acid	5	7
Cucurbitacin B	2	7
Ginseng	2	7
Kaempferol	5	7
Pomegranate	5	7
Reishi Mushroom	5	7
Rosemary	4	7
Silymarin	4	7
Astragalus	3	6
Bee Propolis	4	6
Blueberry	4	6
Capsaicin	4	6
Fenugreek	3	6
Honey	4	6
Pterostilbene	5	6
Puerarin	3	6
Sea buckthorn	4	6
Spirulina	3	6
Achiote	1	5
Alpha-Lipoic Acid	3	5
Amurensin G	1	5
Astaxanthin	4	5
Betulinic acid	3	5
Cannabis	3	5
Chrysin	4	5
Citral	1	5
Gingerol	1	5
Glutathione	3	5
Grape Seed Extract	4	5
Lemongrass	1	5
Lotus	3	5
Panaxadiol	1	5
Phenethyl isothiocyanate	4	5
Sesamin	1	5
Vitamin K	5	5
Apigenin	3	4
Apple Polyphenols	2	4
Arginine	2	4
Bisdemethoxycurcumin	3	4
Black Tea	2	4
Blackberry	2	4
Cannabinoids	2	4
Carnosine	2	4
Carotenoids	4	4
Chamomile	2	4
Cinnamon	3	4
Clove	3	4
Dandelion	3	4
Emodin	2	4
Eugenol	3	4
Ginseng (Korean)	2	4
Honokiol	3	4
Lactobacillus plantarum	2	4
Onion	2	4
Oregano	3	4
Parthenolide	2	4
Piceatannol	3	4
Red Clover	2	4
Red Sage	2	4
Rhubarb	2	4
Soy Protein	2	4
Tangeretin	3	4
Taurine	2	4
Thyme	3	4
Thymol	4	4
Ursolic Acid	3	4
Vitamin A	3	4
Apple	2	3
Artichoke	2	3
Beans: All	2	3
Bromelain	3	3
Carvacrol	3	3
Chinese Skullcap	2	3
Citrus Peel	2	3
Curcuminoids	2	3
DHA (Docosahexaenoic Acid)	2	3
Fig	2	3
Fucoidan	2	3
Indole-3-Carbinol	2	3
Isoflavones	2	3
Isothiocyanates	3	3
Marjoram	2	3
Medicinal Mushrooms	2	3
Mistletoe	2	3
Mugwort	2	3
Myo-inositol	2	3
Nobiletin	2	3
Olive	2	3
Probiotics	2	3
Shiitake Mushroom	2	3
St. Johns Wort	2	3
Tomato	3	3
White Tea	2	3
Acai	2	2
Adlay	1	2
Andrographis	1	2
Arctigenin	2	2
Artesunate	1	2
Asiatic Acid	1	2
Bael	1	2
Baicalein	2	2
Bamboo	1	2
Banana	1	2
Bee Venom	2	2
Beta-Caryophyllene	2	2
Beta-glucan	1	2
Black Bean	1	2
Boswellia	1	2
Broccoli	2	2
Chlorogenic Acid	1	2
Chokeberry	2	2
Chrysanthemum Indicum	1	2
Coconut	1	2
Coptidis rhizoma	1	2
Creatine	1	2
Crocetin	1	2
Cumin	2	2
Daidzein	2	2
Dates	1	2
Dogwood	1	2
Eriodictyol	1	2
Fermented Foods and Beverages	1	2
Fruit: All	2	2
Fucoxanthin	1	2
GABA (gamma-Aminobutyric Acid)	1	2
Gardenia	1	2
Glutamine	1	2
Glycoaminoglycans	1	2
Glycyrrhizin	1	2
Graviola	1	2
Guar gum	1	2
Guduchi	2	2
Hawthorn	1	2
Hedyotis corymbosa	1	2
Hibiscus sabdariffa	1	2
Holy Basil	1	2
Hu Zhang (Polygonum cuspidatum)	1	2
Huperzine	1	2
Insulin-like Growth Factor (IGF-1)	1	2
Irvingia gabonensis	1	2
Kahweol	2	2
Kudzu	1	2
L-Carnitine	1	2
L-arginine	1	2
Lactobacillus rhamnosus GG	2	2
Lavender	1	2
Lemon	1	2
Ligustrazine	1	2
Lion's Mane (Hericium Erinaceus)	1	2
Loquat	1	2
Lupeol	1	2
Lychee	1	2
Maitake Mushroom	2	2
Manganese	1	2
Mint	1	2
Niacin	1	2
Oats	1	2
Oleanolic acid	1	2
Olive leaf extract	1	2
Oridonin	2	2
Paeoniflorin	1	2
Pea Protein	1	2
Peanut	1	2
Peppermint	1	2
Piperlongumine	2	2
Polyunsaturated Fatty Acids (PUFAs)	2	2
Pomegranate Peel	1	2
Pumpkin	1	2
Pumpkin Seeds	1	2
Purple Carrots	1	2
Raspberry	2	2
Rose Hips	2	2
Rutin	2	2
Safflower	1	2
Sage	2	2
Salvia miltiorrhiza	1	2
Schisandra	1	2
Silver (nanoparticles)	1	2
Spikenard	1	2
Stilbenes	2	2
Tamarind	1	2
Tetrahydrocurcumin	1	2
Theanine	1	2
Triptolide	1	2
Urolithin A	1	2
Vitamin K2	1	2
Water: Deuterium Depleted	1	2
Yerba Santa	1	2
Zeolite	1	2
Acerola	1	1
Alpha Linolenic Acid	1	1
Anise	1	1
Antioxidant formulas	1	1
Antrodia camphorata	1	1
Bai Zhu	1	1
Basil	1	1
Bay leaf	1	1
Benzyl isothiocyanate	1	1
Berries: All	1	1
Beta Sitosterol	1	1
Beta-Elemene	1	1
Biochanin A	1	1
Black Currant	1	1
Black Tea Theaflavins	1	1
Burdock	1	1
Butyrate	1	1
Caffeine	1	1
Caffeoylquinic Acids	1	1
Camu Camu	1	1
Cardamom	1	1
Carnosine	1	1
Carsonic Acid	1	1
Cherry: All Varieties	1	1
Chitosan	1	1
Chlorella (Algae)	1	1
Copper	1	1
Cordyceps Militaris	1	1
Coriandor	1	1
Cranberry Proanthocyanidins	1	1
Cryptoxanthin	1	1
Culinary Herbs and Spices	1	1
Curcuma Longa	1	1
D-Limonene	1	1
Demethoxycurcumin	1	1
Diallyl sulfide	1	1
Dill	1	1
Diosgenin	1	1
Ellagic Acid	1	1
Evodiamine	1	1
Galbanic Acid	1	1
Garcinia dulcis	1	1
Gold (nanoparticles)	1	1
Grape	1	1
Grapes	1	1
Guava	1	1
Hydrogen Peroxide	1	1
Indian Gooseberry	1	1
Inositol Hexaphosphate	1	1
Kimchi	1	1
Lactobacillus casei	1	1
Lavender: Essential Oil	1	1
Lecithin	1	1
Lemon Balm	1	1
Lettuce	1	1
Lingonberry	1	1
Linoleic acid	1	1
Long Pepper	1	1
Lutein	1	1
Magnesium	1	1
Magnolol	1	1
Mango	1	1
Milk	1	1
Modified Arabinoxylan Rice Bran (MGN-3)	1	1
Modified Citrus Pectin	1	1
Modified Rice Bran (MGN-3)	1	1
Monolaurin	1	1
Mulberry	1	1
Mustard Oil	1	1
Myricetin	1	1
Myrrh	1	1
Naringenin	1	1
Nettle	1	1
Nisin	1	1
Noni	1	1
Oak	1	1
Onions	1	1
Orange: Mandarin	1	1
Palmitoylethanolamide	1	1
Papain	1	1
Plum	1	1
Potassium	1	1
Psychedelics:All	1	1
Rice Bran	1	1
Rooibos	1	1
Rose	1	1
S-Adenosylmethionine (SAMe)	1	1
Saffron	1	1
Shikonin	1	1
Strawberry	1	1
Tansy	1	1
Tea	1	1
Tea: Oolong	1	1
Testosterone	1	1
Theaflavins	1	1
Thiamine (B-1)	1	1
Thujae occidentalis	1	1
Toad	1	1
Tocopherols	1	1
Tocotrienol: Delta	1	1
Tomatidine	1	1
Toona sinensis	1	1
Ubiquinol	1	1
Vanadium	1	1
Vegetables: All	1	1
Vitamin E: Gamma-tocotrienol	1	1
Vitamin E: delta-tocopherol	1	1
Walnut	1	1
Water: Deep Sea	1	1
Watercress	1	1
Whey	1	1
Xanthohumol	1	1
Yeast	1	1
Zataria multiflora	1	1
beta-Carotene	1	1
neohesperidin	1	1

Name	AC	CK
Aromatherapy	1	10
Mediterranean diet	1	10
Light Therapy	2	4
Acupuncture	1	2
Dietary Modification: Low Carbohydrate/Ketogenic	1	2
Exercise: Endurance	1	2

Name	AC	CK
Antioxidants	95	188
Apoptotic	113	168
Antiproliferative	108	152
Anti-Inflammatory Agents	54	143
Neuroprotective Agents	43	90
Hepatoprotective	24	62
Chemopreventive	33	57
Hypolipidemic	13	50
Antineoplastic Agents	22	48
Anticarcinogenic Agents	20	45
Tumor Necrosis Factor (TNF) Alpha Inhibitor	19	45
Cell cycle arrest	27	40
Interleukin-6 Downregulation	16	39
Anticholesteremic Agents	7	38
Antihypertensive Agents	6	36
Hypoglycemic Agents	15	35
NF-kappaB Inhibitor	24	31
Cardioprotective	11	27
Antiviral Agents	7	26
Chemotherapeutic	11	26
Immunomodulatory	14	24
Interleukin-1 beta downregulation	9	24
Anti-Bacterial Agents	19	23
Cyclooxygenase 2 Inhibitors	17	21
Nrf2 activation	9	21
Chemosensitizer	10	19
Anti-metastatic	15	17
Analgesics	5	16
Tumor Suppressor Protein p53 Upregulation	11	16
Antimicrobial	12	13
Anti-Apoptotic	6	12
Insulin Sensitizers	2	12
Prophylactic Agents	2	12
Renoprotective	6	12
Chemoprotective Agents	6	11
Angiogenesis Inhibitors	6	10
Anti-Infective Agents	1	10
Dermatologic Agents	1	10
MicroRNA modulator	7	10
Vascular Cell Adhesion Molecule-1 Inhibitor	1	10
Anti-Fibrotic	5	9
Matrix metalloproteinase-2 (MMP-2) inhibitor	6	8
Vascular Endothelial Growth Factor Inhibitors	4	8
Antinoceceptive	4	7
Bcl-2 protein down-regulation	7	7
Cytoprotective	4	7
Cytotoxic	5	7
Matrix metalloproteinase-9 (MMP-9) inhibitor	6	7
Anti-Tumor	3	6
Vasodilator Agents	3	6
Gastroprotective	3	5
Heme oxygenase-1 up-regulation	3	5
Acetylcholinesterase Inhibitor	3	4
Antidepressive Agents	2	4
Antifungal Agents	3	4
Brain-derived neurotrophic factor modulator	2	4
Interleukin-8 downregulation	3	4
Superoxide Dismutase Up-regulation	2	4
Vascular Endothelial Growth Factor A Inhibitor	3	4
Alpha-amylase inhibitor	2	3
Alpha-glucosidase inhibitor	2	3
Antimalarials	2	3
Caspase-3 Activation	3	3
Immunostimulatory	2	3
Radioprotective	2	3
Anti-Adipogenic	2	2
Anti-Angiogenic	1	2
Anti-Ulcer Agents	1	2
Anti-atherogenic	1	2
Antioxidant	1	2
Autophagy Up-regulation	2	2
Bax/Bcl2 Ratio: Decrease	1	2
Bone Density Conservation Agents	1	2
Cardiovascular Agents	1	2
Cyclin D1 Down-Regulation	2	2
Detoxifier	1	2
Gastrointestinal Agents	1	2
Genoprotective	1	2
Histone deacetylase inhibitor	1	2
Interferon-gamma (IFN-gamma) inducer	1	2
Interleukin-17 downregulation	1	2
Interleukin-18 down-regulation	1	2
Interleukin-4 downregulation	1	2
Interleukin-5 downregulation	1	2
Leishmanicidal	1	2
Malondialdehyde Down-regulation	1	2
Neurogenesis	1	2
Neurorestorative	1	2
Nitric Oxide Inhibitor	1	2
Osteoprotective	1	2
Pancreato Protective Agents	1	2
Radiosensitizer	1	2
Regenerative	1	2
STAT3 Inhibitor	2	2
Transforming growth factor beta (TGF-β) inhibitor	2	2
Uricosuric Agents	1	2
Vascular Endothelial Growth Factor Regulator	1	2
Wnt/β-catenin pathway down-regulation	1	2
Wnt/β-catenin signaling pathway modulation	2	2
12-lipoxygenase (12-LOX) Inhibitor	1	1
Anabolic Agents	1	1
Anti-Asthmatic Agents	1	1
Anti-cancer	1	1
Antiprotozoal Agents	1	1
Cyclooxygenase Inhibitors	1	1
Enzyme Inhibitors	1	1
Estrogen Receptor Agonist	1	1
Heat Shock Protein Inducer	1	1
Interleukin-10 downregulation	1	1
NF-E2-Related Factor-2 (Nrf2) Modulator	1	1
Neuritogenic	1	1
P21 Activation	1	1
Paraptosis	1	1
Phase II Detoxification Enzyme Inducer	1	1
Photoprotective	1	1
Postaglandin PGE2 downregulation	1	1
SIRT1 Activator	1	1
Survivin Down-Regulation	1	1
TRAIL sensitizer	1	1
Telomerase Upregulation	1	1
Vascular smooth muscle cell (VSMC) inhibitor	1	1

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Synergistic and hepatoprotective effect of total glucosides of paeony on ankylosing spondylitis.Dec 31, 2018

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Pubmed Data : J Drugs Dermatol. 2014 Sep ;13(9):1092-7. PMID: 25226010

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Pubmed Data : J Med Food. 2018 May ;21(5):511-520. Epub 2018 Apr 30. PMID: 29708818

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Pubmed Data : Pain Manag. 2016 Nov 21. Epub 2016 Aug 21. PMID: 27866449

Article Published Date : Nov 20, 2016

Study Type : Human Study

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Substances : Magnesium Sulfate

Diseases : Morphine Tolerance/Dependence

Additional Keywords : Natural Substance Synergy

[+]

Metabolised pycnogenol induces apoptosis in human fibrosarcoma cells.Mar 31, 2015

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Pubmed Data : Int J Oncol. 2015 Apr ;46(4):1629-36. Epub 2015 Jan 27. PMID: 25625225

Article Published Date : Mar 31, 2015

Study Type : Human Study

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Substances : Pycnogenol (Pine Bark)

Diseases : Fibrosarcoma

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic

Additional Keywords : Gene Expression Regulation, Natural Substance Synergy

[+]

Multi-nutrient supplementation improved cognition and mobility in able older females at clinically relevant levels.Jan 31, 2016

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Pubmed Data : Complement Ther Med. 2015 Apr ;23(2):165-74. Epub 2015 Jan 14. PMID: 25847554

Article Published Date : Mar 31, 2015

Study Type : Human Study

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Substances : Nigella sativa (aka Black Seed), Turmeric

Diseases : Metabolic Diseases

Pharmacological Actions : Antihypertensive Agents, Hypoglycemic Agents, Hypolipidemic

Additional Keywords : Natural Substance Synergy, Significant Treatment Outcome

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The combination of vitamin B-12 and fish oil has a synergistic effect on lowering plasma concentrations of homocysteine.Dec 31, 2014

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Pubmed Data : Asia Pac J Clin Nutr. 2015 ;24(3):403-11. PMID: 26420180

These findings suggest a possible synergistic effect of nano-curcumin and coenzyme Q10 on clinical features of migraine.Jun 25, 2019

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Pubmed Data : Nutr Neurosci. 2019 Jun 26:1-10. Epub 2019 Jun 26. PMID: 31241007

Article Published Date : Jun 25, 2019

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10, Curcumin

Diseases : Headache: Migraine

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Prophylactic Agents

Additional Keywords : Natural Substance Synergy

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Twelve-week use of curcumin complex or its combination with boswellic acid reduces pain-related symptoms in patients with osteoarthritis.Jan 08, 2018

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Pubmed Data : BMC Complement Altern Med. 2018 Jan 9 ;18(1):7. Epub 2018 Jan 9. PMID: 29316908

Panaxadiol and Epigallocatechin Gallate have a synergistic apoptotic effect on human colorectal cancer cells.May 08, 2012

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Pubmed Data : Phytother Res. 2012 May 8. Epub 2012 May 8. PMID: 22566066

Article Published Date : May 08, 2012

Study Type : Human In Vitro

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Substances : Catechin , EGCG (Epigallocatechin gallate), Ginseng, Green Tea, Panaxadiol

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Natural Substance Synergy

[+]

The annatto constituent cis-bixin has intriguing selective anti-myeloma activity.Sep 30, 2010

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Pubmed Data : Med J Malaysia. 2021 01 ;76(1):80-86. PMID: 33510114

A combination of virgin coconut oil and extra virgin olive oil elicits superior protection against doxorubicin cardiotoxicity in rats.Jan 28, 2022

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Pubmed Data : Turk J Pharm Sci. 2022 04 29 ;19(2):138-144. PMID: 35509244

Article Published Date : Jan 28, 2022

Study Type : Animal Study

Additional Links

Substances : Coconut, Olive Oil

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Cardioprotective, Chemoprotective Agents

Additional Keywords : Natural Substance Synergy

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A curcumin-artemisinin combination is effective for malaria. May 01, 2006

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Pubmed Data : Antimicrob Agents Chemother. 2006 May;50(5):1859-60. PMID: 16641461

Article Published Date : May 01, 2006

Study Type : Animal Study

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Substances : Artemisinin, Curcumin

Diseases : Malaria

Additional Keywords : Natural Substance Synergy

[+]

A diet containing a mixture of P. montana and red ginseng extracts reversed learning and memory impairments.Jul 31, 2018

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Pubmed Data : J Basic Clin Physiol Pharmacol. 2015 May 1 ;26(3):237-51. PMID: 25918918

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Pubmed Data : Mol Cancer Ther. 2010 Jan ;9(1):180-9. Epub 2010 Jan 6. PMID: 20053780

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View the Evidence: 564 Abstracts with Natural Substance Synergy Research

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Synergistic and hepatoprotective effect of total glucosides of paeony on ankylosing spondylitis.Dec 31, 2018

A case-control nutrigenomic study on the synergistic activity of folate and vitamin B12 in cervical cancer progression.Dec 31, 2011

A combination of curcumin and fennel essential oil significantly improved symptoms and quality of life in IBS patients over 30 days.May 31, 2016

A combination of green tea and ginkgo biloba extracts effectively improved skin conditions and the improvement of skin elasticity.Aug 31, 2014

A combination of selenium and silymari led to a significant reduction in PSA levels.Dec 14, 2013

A functional beverage of mangosteen, aloe vera, green tea, and multivitamins enhances plasma antioxidant capacity in healthy adults.Dec 31, 2014

A herbal formulation is a safe and effective intervention for management of joint discomfort.Apr 30, 2018

A joint consumption of apple juice, natural antioxidants and polyphenols might provide mild favorable effects on cardiometabolic markers, as compared to apple polyphenols alone.Nov 30, 2014

Acute effects of combined Bacopa, American ginseng and whole coffee fruit on working memory and cerebral haemodynamic response of the prefrontal cortex.Nov 17, 2019

An anthocyanin mixture reduced the inflammatory response in hypercholesterolemic subjects.Aug 31, 2013

Chemopreventive synergism between green tea extract and curcumin in patients with potentially malignant oral disorders.Apr 30, 2020

Co-administration of flaxseed and hesperidin appears to be superior to either supplementation alone on metabolic syndrome treatment.Apr 14, 2020

Coenzyme Q10 and vitamin E had beneficial effects on cardiometabolic outcomes among women with polycystic ovary syndrome.Jan 31, 2019

Constitutes of Boswellia serrata extract act synergistically to exert anti-inflammatory/anti-arthritic activity.Mar 05, 2019

CoQ10 and vitamin E supplementation had beneficial effects on serum FBS and insulin levels as well as HOMA-IR and total testosterone levels.Sep 06, 2018

Essential oils of black pepper and angelica reduced the level of nicotine craving and allowed a longer delay before next use of tobacco.Jul 31, 2013

Gazpacho soup consumption is associated with a lower prevalence of hypertension.Sep 30, 2013

Grapefruit juice enhances the systolic blood pressure-lowering effects of dietary nitrate-containing beetroot juice. Jun 09, 2020

Increased dietary ω-3 polyunsaturated fatty acids and extra virgin olive oil have beneficial synergistic effects on lipid metabolism and oxidative stress in patients with MetS.May 31, 2015

Magnesium sulphate increased the potency of morphine thereby reducing the amount of postoperative pain killer needed.Nov 20, 2016

Metabolised pycnogenol induces apoptosis in human fibrosarcoma cells.Mar 31, 2015

Multi-nutrient supplementation improved cognition and mobility in able older females at clinically relevant levels.Jan 31, 2016

Nattokinase combined with red yeast rice, but not nattokinase alone, has potent effects on blood lipids in human subjects with hyperlipidemia.Jan 01, 2009

Pine cone lignin and ascorbic acid combination has a potent antiviral activity, promoting faster healing, reduction of symptoms and reducing the frequency of recurrence episodes in HSV-1.Oct 31, 2009

Study suggests link between tea consumption and vitamin D levelsAug 19, 2012

The administration of cranberries, L. rhamnosus, and vitamin C might represent a safe and effective option in women with recurrent UTIs.Jun 06, 2016

The combination hazelnut and cocoa may act in a synergic and protective way on cardiovascular system.Jul 08, 2017

The combination of black seeds and turmeric can be recommended with lifestyle modification as a starting point for patients with MetS to halt its future complications and progression.Mar 31, 2015

The combination of vitamin B-12 and fish oil has a synergistic effect on lowering plasma concentrations of homocysteine.Dec 31, 2014

The consumption of cooked whole eggs is an effective way to increase the absorption of α-tocopherol and γ-tocopherol from foods.Oct 31, 2016

The consumption of nuts is associated with better dietary and lifestyle patterns in Polish adults.Jun 21, 2019

The present study results showed that curcumin-piperine co-supplementation in outpatients with COVID-19 could significantly reduce weakness.Jun 05, 2022

The results of the present study indicate that a dietary pattern characterised by the intake of lignans, quercetin and resveratrol may play a protective role in the development of oesophageal cancersNov 30, 2014

There is a synergistic interplay between curcumin and polyphenol-rich foods in the Mediterranean diet.Jul 20, 2017

These findings suggest a possible synergistic effect of nano-curcumin and coenzyme Q10 on clinical features of migraine.Jun 25, 2019

Twelve-week use of curcumin complex or its combination with boswellic acid reduces pain-related symptoms in patients with osteoarthritis.Jan 08, 2018

Use of aloe vera and turmeric paste as a supplementary medicine in oral submucosal fibrosis.Sep 30, 2019

Zinc and the Chinese herbal formula Jinye Baidu granule significantly increase the negative conversion rate of HCMV-IgM.May 01, 2005

ω-3 fatty acids and curcumin supplementation can be considered as a new promising approach in migraine management.May 31, 2017

Amurensin G augmented the cytotoxic and apoptotic effects of TRAIL in TRAIL resistant leukemic cells.Jul 31, 2012

Combination treatments with luteolin and fisetin may be a potential candidate for the treatment and prevention of diabetes and its complications.Jun 25, 2017

Cucurbitacin B in the combination with curcumin could serve as a novel, promising approach for human hepatoma.Oct 05, 2015

Curcumin and citral in combination may be a useful therapeutic intervention for breast cancer.Aug 31, 2015

Panaxadiol and Epigallocatechin Gallate have a synergistic apoptotic effect on human colorectal cancer cells.May 08, 2012

The annatto constituent cis-bixin has intriguing selective anti-myeloma activity.Sep 30, 2010

The synergistic antiproliferative action of combined γ-tocotrienol and sesamin treatment in mouse and human mammary cancer cells was cytostatic, not cytotoxic.Dec 31, 2012

Vitamin D and beta-glucans synergically stimulate human macrophage activity.May 03, 2021

γ-tocotrienol and 6-gingerol when used in combination act synergistically increasing cytotoxicity and apoptosis in cancer cells.Dec 31, 2014

Antidiabetic potential and high synergistic antibacterial activity of silver nanoparticles synthesised with Musa Paradisiaca tepal extract.Dec 31, 2020

Irvingia gabonensis extract has an analgesic effect.Jun 01, 2009

SKN-1 is involved in combination of apple peels and blueberry extracts synergistically protecting against oxidative stress in Caenorhabditis elegans.Jun 23, 2020

Synergistic lipid-lowering effects of Zingiber mioga and Hippophae rhamnoides extracts.Aug 31, 2020

A cocktail of betulinic acid, parthenolide, honokiol and ginsenoside Rh2 in liposome systems for lung cancer treatment.Dec 31, 2019

A combination of black bean peel and pomegranate peel extracts, have the ability to ameliorate hyperglycemia by inhibiting oxidative stress induced damage to the pancreas.Dec 31, 2014

A combination of black seeds and turmeric at low doses showed enhanced efficacy in preventing metabolic syndrome in fructose fed rats.Jan 31, 2015

A combination of chamomile and oregano extracts could form a new class of drugs to treat diabetic complications.Sep 01, 2016

A combination of five main alkaloids from Rhizoma Coptidis showed a synergetic cholesterol-lowering efficacy.Apr 14, 2016

A combination of Korean red ginseng extract and Glycyrrhiza glabra L. extract enhances their individual anti-obesity properties.Feb 29, 2020

A combination of lycopene and vitamin E acted in a synergistic fashion to bring significant effects against oxidative stress in tauopathies.Dec 31, 2016

A combination of piperine and ferulic acid might be an alternative therapy in the treatment of psychiatric disorders with high efficacy and low side effects.Jul 29, 2015

A combination of pomegranate, date fruit and date seeds led to a more potent treatment result than each alone. Mar 25, 2015

A combination of resveratrol and curcumin is effective against aluminum chloride-induced neuroinflammation in rats.Feb 06, 2017

A combination of virgin coconut oil and extra virgin olive oil elicits superior protection against doxorubicin cardiotoxicity in rats.Jan 28, 2022

A curcumin-artemisinin combination is effective for malaria. May 01, 2006

A diet containing a mixture of P. montana and red ginseng extracts reversed learning and memory impairments.Jul 31, 2018

A ketogenic diet combined with melatonin overcomes cisplatin and vincristine drug resistance in breast carcinoma syngraft.Nov 26, 2019

A quercetin, EGCG and apple polyphenol concentrate improved disorders of lipid metabolism and pro-oxidant-antioxidant homeostasis.Dec 31, 2016

A sea buckthorn and olive oil mixture could be considered as an alternative dressing for full-thickness burns.Jun 30, 2014

A sulfated polysaccharide, fucoidan, enhances the immunomodulatory effects of lactic acid bacteria.Feb 29, 2012

ACE exhibits anti-hyperlipidemia properties and is associated with partially synergistic effects compared with AI or CL alone.Jul 22, 2015

Administration of melatonin and vitamin C as radioprotectors before irradiation may reduce genotoxicity caused by x-ray irradiation.Dec 31, 2015

Administration of vitamins C and E in combination may exert synergistic antinociceptive effects.Dec 31, 2010

Natural Substance Synergy

View the Evidence:
564 Abstracts with Natural Substance Synergy Research