Natural Substance Synergy

Name	AC	CK
Aluminum Chloride	2	4
Benzo(a)pyrene	2	4
Sodium Fluoride	2	4
Acetaminophen	1	2
Aflatoxin	1	2
Alloxan	1	2
Arsenite	1	2
Concanavalin A	1	2
Monosodium Glutamate (MSG)	1	2
Mycotoxin	1	2
Nicotine	1	2
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	2
Paracetamol	1	2
Antibiotics	1	1

Name	AC	CK
Oxidative Stress	35	65
Breast Cancer	34	49
Prostate Cancer	26	32
Inflammation	18	26
Cardiovascular Diseases	6	25
Lung Cancer	16	24
Osteoarthritis: Knee	3	21
C-Reactive Protein	2	20
Hyperlipidemia	6	20
Cognitive Decline/Dysfunction	6	19
Colon Cancer	17	19
Colorectal Cancer	9	19
Diabetic Complications	8	18
Breast Cancer: Triple Negative	9	17
Liver Cancer	11	17
Cervical Cancer	6	16
Cancers: All	12	14
Diabetes Mellitus: Type 2	8	14
Hypertension	3	14
Atherosclerosis	2	12
Cardiovascular Disease: Prevention	2	12
Hypercholesterolemia	2	12
Metabolic Diseases	2	12
Obesity	7	12
Vitamin D Deficiency	2	12
Alzheimer's Disease	8	11
Hyperglycemia	4	11
Aging Skin	1	10
Cholesterol: High	1	10
Cytomegalovirus Infections	1	10
Esophageal Cancer	1	10
Fibrosarcoma	1	10
Folic Acid/Folate Deficiency	1	10
Headache: Migraine	1	10
Herpes Simplex Virus Type 1	1	10
High Cholesterol	1	10
Homocysteine: Elevated	1	10
Irritable Bowel Syndrome	1	10
Morphine Tolerance/Dependence	1	10
Neurofibromatosis	1	10
Osteoarthritis	1	10
Polycystic Ovary Syndrome	1	10
Prostate: PSA Doubling	1	10
Prostatic Hyperplasia	1	10
Smoking Cessation: Nicotine Addiction	1	10
Urinary Tract Infections	1	10
Chemically-Induced Liver Damage	5	9
Lipid Peroxidation	5	9
Melanoma	7	9
Brain Inflammation	4	8
Diabetes: Oxidative Stress	4	8
Multiple Myeloma	3	8
Myocardial Infarction	4	8
Parkinson's Disease	5	8
Insulin Resistance	4	7
Neurodegenerative Diseases	5	7
Pancreatic Cancer	6	7
Acute Myeloid Leukemia	5	6
High Fat Diet	3	6
Promyelocytic leukemia	6	6
Sepsis	3	6
Wound Healing	3	6
Cancers: Drug Resistant	1	5
Cancers: Multi-Drug Resistant	1	5
Escherichia coli Infections	5	5
Head and Neck Cancer	3	5
Leukemia: Chronic myelogenous leukemia (CML)	1	5
Malaria	3	5
Oral Cancer	5	5
Staphylococcus aureus infection	5	5
Aluminum Toxicity	2	4
Cadmium Poisoning	2	4
Cancer Metastasis	2	4
Cerebral Ischemia	2	4
Cholestasis	2	4
Cholesterol: Oxidation	2	4
Diabetes Mellitus: Type 1	2	4
Dyslipidemias	2	4
Endothelial Dysfunction	2	4
Fluoride Toxicity	2	4
Gastric Cancer	4	4
Glioblastoma	3	4
Hypoglycemia	3	4
Liver Fibrosis	2	4
Prostate Cancer: Prevention	3	4
Triglycerides: Elevated	2	4
Ulcerative Colitis	2	4
Brain Ischemia	2	3
Candida Albicans	2	3
Carcinoma: Non-Small-Cell Lung	2	3
Chronic Pain	2	3
Colon Cancer: Prevention	2	3
Colorectal Cancer: Prevention	2	3
DNA damage	2	3
Dementia	2	3
Human Papillomavirus (HPV)	2	3
Lipopolysaccharide-Induced Toxicity	3	3
Listeria Infections	3	3
Nonalcoholic fatty liver disease (NAFLD)	2	3
Osteoporosis	2	3
Squamous cell carcinoma	3	3
Staphylococcus aureus: Methicillin-resistant (MRSA)	3	3
Acetaminophen (Tylenol) Toxicity	1	2
Aging: Heart	1	2
Amyotrophic Lateral Sclerosis	1	2
Androgen-Induced Diseases	1	2
Arteriosclerosis	1	2
Avian Influenza	1	2
Bacterial Infections	1	2
Bowel Surgery	1	2
Brain Cancer	1	2
Breast Cancer: Chemically-Induced	2	2
Burns	1	2
Cancers	2	2
Candidiasis: Vulvovaginal	1	2
Chemotherapy and Radiation Toxicity	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Chronic Myeloid Leukemia	1	2
Depressive Disorder	1	2
Diabetes	1	2
Diabetic Neuropathy	1	2
Dry Eye Syndromes	1	2
Emesis	1	2
Fructose-Induced Toxicity	1	2
Gallstones	1	2
Gout	1	2
Heart Failure	1	2
Hepatitis C	1	2
Huntington Disease	1	2
Hyperalgesia	1	2
Hyperinsulinism	1	2
Hyperuricemia	1	2
Immune Dysregulation: TH1/TH2 imbalance	1	2
Influenza A	1	2
Iron Poisoning	1	2
Leishmaniasis	1	2
Leukemia	2	2
Leukemia: Chronic Lymphocytic Leukemia (CLL)	2	2
Liver Cancer: Prevention	1	2
Liver Cirrhosis	1	2
Liver Damage	1	2
Liver Damage: Aflatoxin-Induced	1	2
Liver Damage: Drug-Induced	1	2
Liver Disease	1	2
Malignant Melanoma	1	2
Memory Disorders	1	2
Menopausal Syndrome	1	2
Motor Neuron Disease	1	2
Multiple Sclerosis	2	2
Myelotoxicity	1	2
Nasopharyngeal Cancer	1	2
Nicotine/Tobacco Toxicity	1	2
Peripheral Neuropathies	1	2
Salmonella Infections	2	2
Skin Cancer: Prevention	1	2
Stress	1	2
Ulcers	1	2
Vomiting	1	2
Abdominal Obesity (Midsection Fat)	1	1
Acinetobacter baumannii infection	1	1
Acute T cell Leukemias	1	1
Aging: Brain	1	1
Arthritis	1	1
Autoimmune Diseases	1	1
Bacillus Cereus infection	1	1
Brain Injury: Hippocampal Damage	1	1
Cancer Stem Cells	1	1
Candida Infection	1	1
Chagas Disease	1	1
Chemotherapy-Induced Toxicity: Doxorubicin	1	1
Chronic Lymphocytic Leukemia	1	1
Dental Implantation	1	1
Encephalomyelitis	1	1
Endometrial Cancer	1	1
Food Poisoning	1	1
Gastrointestinal Inflammation	1	1
Gonorrhea	1	1
Gram-Positive Bacterial Infections	1	1
Kidney Cancer	1	1
Learning disorders	1	1
Leiomyosarcoma	1	1
Leukemia: Acute myelogenous leukemia (AML)	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Lymphoma	1	1
Micrococcus luteus infections	1	1
Neuroblastoma	1	1
Neurodevelopmental Disorders	1	1
Neurologic Disorders	1	1
Neurological Conditions	1	1
Non-Small-Cell Lung Carcinoma	1	1
Osteoclastoma	1	1
Osteopenia	1	1
Ovarian Cancer	1	1
Periodontitis	1	1
Photooxidative Stress	1	1
Pseudomonas aeruginosa	1	1
Renal Cancer	1	1
Rotavirus Infections	1	1
Skin Cancer	1	1
Tongue Cancer	1	1

Name	AC	CK	Focus
Radiotherapy	1	2

Name	AC	CK
Curcumin	75	150
Vitamin C	27	67
Resveratrol	32	52
Green Tea	15	50
Quercetin	30	49
Polyphenols	16	46
EGCG (Epigallocatechin gallate)	25	37
Vitamin D	25	34
Vitamin E	16	33
Frankincense	4	31
Omega-3 Fatty Acids	3	30
Turmeric	9	30
Vitamin B-12	3	30
Piperine	16	29
Selenium	12	27
Vitamin E: alpha tocopherol	6	27
Fish Oil	5	25
Ginkgo biloba	3	22
Catechin	13	20
Folic Acid	2	20
Lignans	2	20
Anthocyanins	7	19
Coenzyme Q10	4	16
Nigella sativa (aka Black Seed)	4	16
Olive Oil	4	15
Melatonin	11	14
Zinc	4	14
Black Pepper	3	13
EPA (Eicosapentaenoic Acid)	3	13
Luteolin	8	12
Riboflavin (Vitamin B-2)	3	12
Tocotrienol: Gamma	4	12
Cocoa	2	11
Cranberry	2	11
Cyanidin 3-glucoside	2	11
Milk Thistle	2	11
Vitamin E: Gamma-Tocopherol	2	11
Aloe Vera	1	10
Angelica	1	10
Apples	1	10
Chinese Herbal Formula: Jinye Baidu	1	10
Delphinidin	1	10
Egg	1	10
Fennel	1	10
Garlic	6	10
Haritaki (Terminalia chebula)	1	10
Hazelnut	1	10
Lactobacillus rhamnosus	1	10
Magnesium Sulfate	1	10
Mangosteen	1	10
NAC (N-acetyl-L-cysteine)	5	10
Nattokinase	1	10
Phosphatidylserine	1	10
Pine Cone	1	10
Pycnogenol (Pine Bark)	1	10
Red Yeast Rice	1	10
Soup	1	10
Thymoquinone	5	10
Vitamin B-5 (Pantothenic Acid)	1	10
acetyl-11-keto-beta-boswellic acid	1	10
Astragaloside	6	9
Fisetin	4	9
Flavonoids	7	9
Sulforaphane	8	9
Berberine	7	8
Cannabidiol	4	8
Delta-tetrahydrocannabinol (THC)	4	8
Ferulic acid	5	8
Artemisinin	5	7
Cucurbitacin B	2	7
Ginsenosides	4	7
Lycopene	4	7
Silibinin	5	7
Capsaicin	4	6
Fenugreek	3	6
Genistein	6	6
Pomegranate	4	6
Spirulina	3	6
Achiote	1	5
Alpha-Lipoic Acid	3	5
Amurensin G	1	5
Carnosic Acid	4	5
Chrysin	4	5
Citral	1	5
Gingerol	1	5
Ginseng	1	5
Grape Seed Extract	4	5
Hesperidin	3	5
Honey	3	5
Lemongrass	1	5
Lotus	3	5
Panaxadiol	1	5
Pterostilbene	4	5
Rosemary	3	5
Sesamin	1	5
Vitamin K	5	5
Apple Polyphenols	2	4
Arginine	2	4
Astragalus	2	4
Black Tea	2	4
Blackberry	2	4
Blueberry	3	4
Carotenoids	4	4
Cinnamon	3	4
Emodin	2	4
Ginger	4	4
Kaempferol	3	4
Onion	2	4
Oregano	3	4
Phenethyl isothiocyanate	3	4
Piceatannol	3	4
Puerarin	2	4
Red Clover	2	4
Red Sage	2	4
Reishi Mushroom	3	4
Sea buckthorn	3	4
Soy Protein	2	4
Tangeretin	3	4
Vitamin A	3	4
Artichoke	2	3
Astaxanthin	2	3
Beans: All	2	3
Bee Propolis	2	3
Cannabis	2	3
Chinese Skullcap	2	3
Citrus Peel	2	3
Clove	2	3
DHA (Docosahexaenoic Acid)	2	3
Fucoidan	2	3
Indole-3-Carbinol	2	3
Isoflavones	2	3
Isothiocyanates	3	3
Licorice	2	3
Medicinal Mushrooms	2	3
Mistletoe	2	3
Mugwort	2	3
Nobiletin	2	3
Olive	2	3
Silymarin	2	3
St. Johns Wort	2	3
Thyme	2	3
Tomato	3	3
Acai	2	2
Adlay	1	2
Andrographis	1	2
Arctigenin	2	2
Asiatic Acid	1	2
Bael	1	2
Baicalein	2	2
Bamboo	1	2
Bee Venom	2	2
Beta-glucan	1	2
Bisdemethoxycurcumin	1	2
Black Bean	1	2
Boswellia	1	2
Broccoli	2	2
Bromelain	2	2
Cannabinoids	1	2
Carnosine	1	2
Chamomile	1	2
Chlorogenic Acid	1	2
Chokeberry	2	2
Chrysanthemum Indicum	1	2
Coconut	1	2
Coptidis rhizoma	1	2
Creatine	1	2
Crocetin	1	2
Cumin	2	2
Daidzein	2	2
Dates	1	2
Eriodictyol	1	2
Fermented Foods and Beverages	1	2
Fruit: All	2	2
Fucoxanthin	1	2
Gardenia	1	2
Ginseng (Korean)	1	2
Glutamine	1	2
Glutathione	1	2
Glycoaminoglycans	1	2
Glycyrrhizin	1	2
Graviola	1	2
Guar gum	1	2
Hawthorn	1	2
Hedyotis corymbosa	1	2
Hibiscus sabdariffa	1	2
Holy Basil	1	2
Honokiol	2	2
Hu Zhang (Polygonum cuspidatum)	1	2
Huperzine	1	2
Insulin-like Growth Factor (IGF-1)	1	2
Irvingia gabonensis	1	2
Kahweol	2	2
Kudzu	1	2
L-Carnitine	1	2
Lemon	1	2
Ligustrazine	1	2
Lion's Mane (Hericium Erinaceus)	1	2
Loquat	1	2
Lupeol	1	2
Lychee	1	2
Manganese	1	2
Marjoram	1	2
Mint	1	2
Myo-inositol	1	2
Niacin	1	2
Oats	1	2
Oleanolic acid	1	2
Olive leaf extract	1	2
Paeoniflorin	1	2
Parthenolide	1	2
Pea Protein	1	2
Peanut	1	2
Piperlongumine	2	2
Polyunsaturated Fatty Acids (PUFAs)	2	2
Pomegranate Peel	1	2
Pumpkin	1	2
Purple Carrots	1	2
Rhubarb	1	2
Rose Hips	2	2
Rutin	2	2
Sage	2	2
Shiitake Mushroom	1	2
Spikenard	1	2
Tamarind	1	2
Taurine	1	2
Ursolic Acid	2	2
Vitamin K2	1	2
Water: Deuterium Depleted	1	2
Yerba Santa	1	2
Zeolite	1	2
Acerola	1	1
Anise	1	1
Antioxidant formulas	1	1
Apigenin	1	1
Apple	1	1
Bai Zhu	1	1
Bay leaf	1	1
Beet	1	1
Benzyl isothiocyanate	1	1
Berries: All	1	1
Beta Sitosterol	1	1
Beta-Caryophyllene	1	1
Beta-Elemene	1	1
Betulinic acid	1	1
Black Currant	1	1
Black Tea Theaflavins	1	1
Burdock	1	1
Butyrate	1	1
Caffeine	1	1
Caffeoylquinic Acids	1	1
Camu Camu	1	1
Cardamom	1	1
Carnosine	1	1
Carsonic Acid	1	1
Carvacrol	1	1
Cherry: All Varieties	1	1
Chitosan	1	1
Chlorella (Algae)	1	1
Coffee	1	1
Copper	1	1
Cordyceps Militaris	1	1
Coriandor	1	1
Cranberry Proanthocyanidins	1	1
Cryptoxanthin	1	1
Culinary Herbs and Spices	1	1
Curcuma Longa	1	1
D-Limonene	1	1
Dandelion	1	1
Diallyl sulfide	1	1
Diosgenin	1	1
Ellagic Acid	1	1
Eugenol	1	1
Evodiamine	1	1
Fig	1	1
Garcinia dulcis	1	1
Gold (nanoparticles)	1	1
Grapes	1	1
Guava	1	1
Hydrogen Peroxide	1	1
Inositol Hexaphosphate	1	1
Kimchi	1	1
Lactobacillus casei	1	1
Lactobacillus rhamnosus GG	1	1
Lavender: Essential Oil	1	1
Lecithin	1	1
Lettuce	1	1
Lingonberry	1	1
Long Pepper	1	1
Lutein	1	1
Magnolol	1	1
Maitake Mushroom	1	1
Mango	1	1
Milk	1	1
Modified Arabinoxylan Rice Bran (MGN-3)	1	1
Modified Citrus Pectin	1	1
Modified Rice Bran (MGN-3)	1	1
Monolaurin	1	1
Mulberry	1	1
Mustard Oil	1	1
Myricetin	1	1
Naringenin	1	1
Nettle	1	1
Nisin	1	1
Noni	1	1
Onions	1	1
Orange: Mandarin	1	1
Oridonin	1	1
Palmitoylethanolamide	1	1
Papain	1	1
Plum	1	1
Potassium	1	1
Psychedelics:All	1	1
Raspberry	1	1
Rice Bran	1	1
Rooibos	1	1
Rose	1	1
S-Adenosylmethionine (SAMe)	1	1
Saffron	1	1
Stilbenes	1	1
Strawberry	1	1
Tea	1	1
Testosterone	1	1
Theaflavins	1	1
Thiamine (B-1)	1	1
Thujae occidentalis	1	1
Toad	1	1
Tocopherols	1	1
Tocotrienol: Delta	1	1
Tomatidine	1	1
Ubiquinol	1	1
Vanadium	1	1
Vegetables: All	1	1
Vitamin E: Gamma-tocotrienol	1	1
Vitamin E: delta-tocopherol	1	1
Walnut	1	1
Water: Deep Sea	1	1
Watercress	1	1
Whey	1	1
Yeast	1	1
Zataria multiflora	1	1
beta-Carotene	1	1

Name	AC	CK
Aromatherapy	1	10
Mediterranean diet	1	10
Light Therapy	2	4
Acupuncture	1	2
Exercise: Endurance	1	2

Name	AC	CK
Apoptotic	96	148
Antioxidants	77	143
Antiproliferative	91	135
Anti-Inflammatory Agents	39	112
Neuroprotective Agents	34	66
Antineoplastic Agents	21	46
Chemopreventive	30	44
Anticholesteremic Agents	7	38
Cell cycle arrest	25	38
Tumor Necrosis Factor (TNF) Alpha Inhibitor	15	37
Anticarcinogenic Agents	18	34
Hepatoprotective	18	34
Interleukin-6 Downregulation	13	33
Hypoglycemic Agents	13	31
Antihypertensive Agents	5	26
Hypolipidemic	9	26
NF-kappaB Inhibitor	20	26
Cardioprotective	10	25
Antiviral Agents	4	23
Interleukin-1 beta downregulation	7	20
Chemotherapeutic	7	19
Immunomodulatory	10	19
Chemosensitizer	9	18
Nrf2 activation	7	18
Analgesics	4	15
Cyclooxygenase 2 Inhibitors	13	15
Tumor Suppressor Protein p53 Upregulation	8	13
Anti-metastatic	9	11
Anti-Bacterial Agents	9	10
Anti-Infective Agents	1	10
Dermatologic Agents	1	10
Vascular Cell Adhesion Molecule-1 Inhibitor	1	10
Angiogenesis Inhibitors	5	9
Anti-Apoptotic	4	8
Antimicrobial	8	8
Renoprotective	4	8
Vascular Endothelial Growth Factor Inhibitors	4	8
Antinoceceptive	4	7
Chemoprotective Agents	4	7
Anti-Fibrotic	3	6
Anti-Tumor	3	6
Matrix metalloproteinase-2 (MMP-2) inhibitor	4	6
MicroRNA modulator	4	6
Vasodilator Agents	3	6
Bcl-2 protein down-regulation	5	5
Matrix metalloproteinase-9 (MMP-9) inhibitor	4	5
Cytoprotective	2	4
Cytotoxic	3	4
Interleukin-8 downregulation	3	4
Superoxide Dismutase Up-regulation	2	4
Vascular Endothelial Growth Factor A Inhibitor	3	4
Alpha-amylase inhibitor	2	3
Caspase-3 Activation	3	3
Gastroprotective	2	3
Heme oxygenase-1 up-regulation	2	3
Acetylcholinesterase Inhibitor	1	2
Anti-Adipogenic	2	2
Anti-Angiogenic	1	2
Anti-Ulcer Agents	1	2
Anti-atherogenic	1	2
Antidepressive Agents	1	2
Antifungal Agents	1	2
Antioxidant	1	2
Autophagy Up-regulation	2	2
Bax/Bcl2 Ratio: Decrease	1	2
Bone Density Conservation Agents	1	2
Brain-derived neurotrophic factor modulator	1	2
Cardiovascular Agents	1	2
Detoxifier	1	2
Genoprotective	1	2
Immunostimulatory	1	2
Insulin Sensitizers	1	2
Interferon-gamma (IFN-gamma) inducer	1	2
Leishmanicidal	1	2
Malondialdehyde Down-regulation	1	2
Neurorestorative	1	2
Nitric Oxide Inhibitor	1	2
Osteoprotective	1	2
Pancreato Protective Agents	1	2
Prophylactic Agents	1	2
Radioprotective	1	2
Radiosensitizer	1	2
Uricosuric Agents	1	2
Vascular Endothelial Growth Factor Regulator	1	2
Wnt/β-catenin pathway down-regulation	1	2
12-lipoxygenase (12-LOX) Inhibitor	1	1
Alpha-glucosidase inhibitor	1	1
Anabolic Agents	1	1
Anti-cancer	1	1
Antimalarials	1	1
Antiprotozoal Agents	1	1
Cyclin D1 Down-Regulation	1	1
Cyclooxygenase Inhibitors	1	1
Enzyme Inhibitors	1	1
Estrogen Receptor Agonist	1	1
Heat Shock Protein Inducer	1	1
Interleukin-10 downregulation	1	1
NF-E2-Related Factor-2 (Nrf2) Modulator	1	1
Neuritogenic	1	1
P21 Activation	1	1
Phase II Detoxification Enzyme Inducer	1	1
Photoprotective	1	1
Postaglandin PGE2 downregulation	1	1
SIRT1 Activator	1	1
STAT3 Inhibitor	1	1
Survivin Down-Regulation	1	1
TRAIL sensitizer	1	1
Telomerase Upregulation	1	1
Transforming growth factor beta (TGF-β) inhibitor	1	1
Vascular smooth muscle cell (VSMC) inhibitor	1	1
Wnt/β-catenin signaling pathway modulation	1	1

[+]

Synergistic and hepatoprotective effect of total glucosides of paeony on ankylosing spondylitis.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : J Drugs Dermatol. 2014 Sep ;13(9):1092-7. PMID: 25226010

Click here to read the entire abstract

Pubmed Data : J Med Food. 2018 May ;21(5):511-520. Epub 2018 Apr 30. PMID: 29708818

Click here to read the entire abstract

Pubmed Data : Pain Manag. 2016 Nov 21. Epub 2016 Aug 21. PMID: 27866449

Article Published Date : Nov 20, 2016

Study Type : Human Study

Additional Links

Substances : Magnesium Sulfate

Diseases : Morphine Tolerance/Dependence

Additional Keywords : Natural Substance Synergy

[+]

Metabolised pycnogenol induces apoptosis in human fibrosarcoma cells.Mar 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Oncol. 2015 Apr ;46(4):1629-36. Epub 2015 Jan 27. PMID: 25625225

Article Published Date : Mar 31, 2015

Study Type : Human Study

Additional Links

Substances : Pycnogenol (Pine Bark)

Diseases : Fibrosarcoma

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic

Additional Keywords : Gene Expression Regulation, Natural Substance Synergy

[+]

Multi-nutrient supplementation improved cognition and mobility in able older females at clinically relevant levels.Jan 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : Complement Ther Med. 2015 Apr ;23(2):165-74. Epub 2015 Jan 14. PMID: 25847554

Article Published Date : Mar 31, 2015

Study Type : Human Study

Additional Links

Substances : Nigella sativa (aka Black Seed), Turmeric

Diseases : Metabolic Diseases

Pharmacological Actions : Antihypertensive Agents, Hypoglycemic Agents, Hypolipidemic

Additional Keywords : Natural Substance Synergy, Significant Treatment Outcome

[+]

The combination of vitamin B-12 and fish oil has a synergistic effect on lowering plasma concentrations of homocysteine.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asia Pac J Clin Nutr. 2015 ;24(3):403-11. PMID: 26420180

Click here to read the entire abstract

Pubmed Data : Br J Nutr. 2014 Dec ;112(12):2002-9. Epub 2014 Oct 27. PMID: 25345471

Article Published Date : Nov 30, 2014

Study Type : Human Study

Additional Links

Substances : Lignans, Quercetin, Resveratrol

Diseases : Esophageal Cancer

Pharmacological Actions : Anticarcinogenic Agents

Additional Keywords : Dietary Modification, Natural Substance Synergy, Plant Extracts

[+]

There is a synergistic interplay between curcumin and polyphenol-rich foods in the Mediterranean diet.Jul 20, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Panaxadiol and Epigallocatechin Gallate have a synergistic apoptotic effect on human colorectal cancer cells.May 08, 2012

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2012 May 8. Epub 2012 May 8. PMID: 22566066

Article Published Date : May 08, 2012

Study Type : Human In Vitro

Additional Links

Substances : Catechin , EGCG (Epigallocatechin gallate), Ginseng, Green Tea, Panaxadiol

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Natural Substance Synergy

[+]

The annatto constituent cis-bixin has intriguing selective anti-myeloma activity.Sep 30, 2010

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Anti Therapeutic Actions : Radiotherapy

[+]

Administration of vitamins C and E in combination may exert synergistic antinociceptive effects.Dec 31, 2010

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2011 ;6(12):e29240. Epub 2011 Dec 14. PMID: 22195029

Article Published Date : Dec 31, 2010

Study Type : Animal Study

Additional Links

Substances : Vitamin C, Vitamin E

Diseases : Hyperalgesia, Inflammation, Peripheral Neuropathies

Pharmacological Actions : Analgesics, Antinoceceptive

Additional Keywords : Natural Substance Synergy

[+]

Amelioration of oxidative stress by dietary fenugreek seeds is potentiated by onion in streptozotocin-induced diabetic rats.Mar 19, 2017

Click here to read the entire abstract

Pubmed Data : Appl Physiol Nutr Metab. 2017 Mar 20. Epub 2017 Mar 20. PMID: 28319671

Click here to read the entire abstract

Pubmed Data : Evid Based Complement Alternat Med. 2017 ;2017:9764843. Epub 2017 Jul 9. PMID: 28769989

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Chrysanthemum Indicum, Cinnamon

Diseases : Gout, Hyperuricemia

Pharmacological Actions : Uricosuric Agents

Additional Keywords : Natural Substance Synergy

[+]

Co-administration of curcumin plus piperine potentiates the hypocholesterolemic effects of curcumin by increasing the activity and gene expression.Jun 30, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drugs Aging. 2007;24(11):945-55. PMID: 20614824

Article Published Date : Jan 01, 2007

Study Type : Animal Study

Additional Links

Substances : Curcumin, Guar gum

Diseases : Colon Cancer, Colorectal Cancer

Additional Keywords : Natural Substance Synergy

[+]

Combining green tea polyphenols and quercetin significantly enhanced the antiproliferative and proapoptotic effect in vivo. Dec 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:7218504. Epub 2018 Nov 26. PMID: 30598686

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Fermented Foods and Beverages, Spirulina

Diseases : Dementia

Pharmacological Actions : Brain-derived neurotrophic factor modulator, Neuroprotective Agents

Additional Keywords : Natural Substance Synergy

[+]

Effect of pea protein plus grape seed dry extract on a murine model of Candida albicans induced vaginitis.Dec 31, 2017

Click here to read the entire abstract

Pubmed Data : Future Microbiol. 2018 09 ;13:1375-1382. Epub 2018 Sep 26. PMID: 30256168

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Carcinogenesis. 2011 Apr ;32(4):561-7. Epub 2011 Jan 27. PMID: 21273642

Article Published Date : Mar 31, 2011

Study Type : Animal Study

Additional Links

Substances : Indole-3-Carbinol, Silibinin

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemopreventive

Additional Keywords : Natural Substance Synergy

[+]

Eriodictyol synergistically potentiates the anti-tumour effect of EGCG by amplifying 67LR-dependent signalling in MM cellsDec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Medicina (Kaunas). 2019 May 21 ;55(5). Epub 2019 May 21. PMID: 31117289

Article Published Date : May 20, 2019

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid, Silibinin, Vitamin C

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidant, Hepatoprotective

Additional Keywords : Natural Substance Synergy

Problem Substances : Acetaminophen, Paracetamol

[+]

Herbal compatibility of ginseng and rhubarb exerts synergistic neuroprotection in cerebral ischemia/reperfusion injury.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Physiol. 2019 ;10:1174. Epub 2019 Sep 13. PMID: 31572219

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Ginseng, Rhubarb

Diseases : Cerebral Ischemia

Natural Substance Synergy jQuery(function ($) { $(".node-field-image").click(function () { $(".node-field-image").toggleClass("open"); }); $(".node.topic>.colfull").click(function () { $(".node.topic>.colfull").toggleClass("open"); }); })

Focus Your Research

Click any topic below to filter + focus research

View the Evidence: 474 Abstracts with Natural Substance Synergy Research

Limited to Members Only

Currently Available Sorting Options

Synergistic and hepatoprotective effect of total glucosides of paeony on ankylosing spondylitis.Dec 31, 2018

A case-control nutrigenomic study on the synergistic activity of folate and vitamin B12 in cervical cancer progression.Dec 31, 2011

A combination of curcumin and fennel essential oil significantly improved symptoms and quality of life in IBS patients over 30 days.May 31, 2016

A combination of green tea and ginkgo biloba extracts effectively improved skin conditions and the improvement of skin elasticity.Aug 31, 2014

A combination of selenium and silymari led to a significant reduction in PSA levels.Dec 14, 2013

A functional beverage of mangosteen, aloe vera, green tea, and multivitamins enhances plasma antioxidant capacity in healthy adults.Dec 31, 2014

A herbal formulation is a safe and effective intervention for management of joint discomfort.Apr 30, 2018

A joint consumption of apple juice, natural antioxidants and polyphenols might provide mild favorable effects on cardiometabolic markers, as compared to apple polyphenols alone.Nov 30, 2014

Acute effects of combined Bacopa, American ginseng and whole coffee fruit on working memory and cerebral haemodynamic response of the prefrontal cortex.Nov 17, 2019

An anthocyanin mixture reduced the inflammatory response in hypercholesterolemic subjects.Aug 31, 2013

Chemopreventive synergism between green tea extract and curcumin in patients with potentially malignant oral disorders.Apr 30, 2020

Co-administration of flaxseed and hesperidin appears to be superior to either supplementation alone on metabolic syndrome treatment.Apr 14, 2020

Coenzyme Q10 and vitamin E had beneficial effects on cardiometabolic outcomes among women with polycystic ovary syndrome.Jan 31, 2019

Constitutes of Boswellia serrata extract act synergistically to exert anti-inflammatory/anti-arthritic activity.Mar 05, 2019

CoQ10 and vitamin E supplementation had beneficial effects on serum FBS and insulin levels as well as HOMA-IR and total testosterone levels.Sep 06, 2018

Essential oils of black pepper and angelica reduced the level of nicotine craving and allowed a longer delay before next use of tobacco.Jul 31, 2013

Gazpacho soup consumption is associated with a lower prevalence of hypertension.Sep 30, 2013

Grapefruit juice enhances the systolic blood pressure-lowering effects of dietary nitrate-containing beetroot juice. Jun 09, 2020

Increased dietary ω-3 polyunsaturated fatty acids and extra virgin olive oil have beneficial synergistic effects on lipid metabolism and oxidative stress in patients with MetS.May 31, 2015

Magnesium sulphate increased the potency of morphine thereby reducing the amount of postoperative pain killer needed.Nov 20, 2016

Metabolised pycnogenol induces apoptosis in human fibrosarcoma cells.Mar 31, 2015

Multi-nutrient supplementation improved cognition and mobility in able older females at clinically relevant levels.Jan 31, 2016

Nattokinase combined with red yeast rice, but not nattokinase alone, has potent effects on blood lipids in human subjects with hyperlipidemia.Jan 01, 2009

Pine cone lignin and ascorbic acid combination has a potent antiviral activity, promoting faster healing, reduction of symptoms and reducing the frequency of recurrence episodes in HSV-1.Oct 31, 2009

Study suggests link between tea consumption and vitamin D levelsAug 19, 2012

The administration of cranberries, L. rhamnosus, and vitamin C might represent a safe and effective option in women with recurrent UTIs.Jun 06, 2016

The combination hazelnut and cocoa may act in a synergic and protective way on cardiovascular system.Jul 08, 2017

The combination of black seeds and turmeric can be recommended with lifestyle modification as a starting point for patients with MetS to halt its future complications and progression.Mar 31, 2015

The combination of vitamin B-12 and fish oil has a synergistic effect on lowering plasma concentrations of homocysteine.Dec 31, 2014

The consumption of cooked whole eggs is an effective way to increase the absorption of α-tocopherol and γ-tocopherol from foods.Oct 31, 2016

The consumption of nuts is associated with better dietary and lifestyle patterns in Polish adults.Jun 21, 2019

The results of the present study indicate that a dietary pattern characterised by the intake of lignans, quercetin and resveratrol may play a protective role in the development of oesophageal cancersNov 30, 2014

There is a synergistic interplay between curcumin and polyphenol-rich foods in the Mediterranean diet.Jul 20, 2017

These findings suggest a possible synergistic effect of nano-curcumin and coenzyme Q10 on clinical features of migraine.Jun 25, 2019

Twelve-week use of curcumin complex or its combination with boswellic acid reduces pain-related symptoms in patients with osteoarthritis.Jan 08, 2018

Use of aloe vera and turmeric paste as a supplementary medicine in oral submucosal fibrosis.Sep 30, 2019

Zinc and the Chinese herbal formula Jinye Baidu granule significantly increase the negative conversion rate of HCMV-IgM.May 01, 2005

ω-3 fatty acids and curcumin supplementation can be considered as a new promising approach in migraine management.May 31, 2017

Amurensin G augmented the cytotoxic and apoptotic effects of TRAIL in TRAIL resistant leukemic cells.Jul 31, 2012

Combination treatments with luteolin and fisetin may be a potential candidate for the treatment and prevention of diabetes and its complications.Jun 25, 2017

Cucurbitacin B in the combination with curcumin could serve as a novel, promising approach for human hepatoma.Oct 05, 2015

Curcumin and citral in combination may be a useful therapeutic intervention for breast cancer.Aug 31, 2015

Panaxadiol and Epigallocatechin Gallate have a synergistic apoptotic effect on human colorectal cancer cells.May 08, 2012

The annatto constituent cis-bixin has intriguing selective anti-myeloma activity.Sep 30, 2010

The synergistic antiproliferative action of combined γ-tocotrienol and sesamin treatment in mouse and human mammary cancer cells was cytostatic, not cytotoxic.Dec 31, 2012

γ-tocotrienol and 6-gingerol when used in combination act synergistically increasing cytotoxicity and apoptosis in cancer cells.Dec 31, 2014

Irvingia gabonensis extract has an analgesic effect.Jun 01, 2009

A cocktail of betulinic acid, parthenolide, honokiol and ginsenoside Rh2 in liposome systems for lung cancer treatment.Dec 31, 2019

A combination of black bean peel and pomegranate peel extracts, have the ability to ameliorate hyperglycemia by inhibiting oxidative stress induced damage to the pancreas.Dec 31, 2014

A combination of black seeds and turmeric at low doses showed enhanced efficacy in preventing metabolic syndrome in fructose fed rats.Jan 31, 2015

A combination of chamomile and oregano extracts could form a new class of drugs to treat diabetic complications.Sep 01, 2016

A combination of five main alkaloids from Rhizoma Coptidis showed a synergetic cholesterol-lowering efficacy.Apr 14, 2016

A combination of Korean red ginseng extract and Glycyrrhiza glabra L. extract enhances their individual anti-obesity properties.Feb 29, 2020

A combination of lycopene and vitamin E acted in a synergistic fashion to bring significant effects against oxidative stress in tauopathies.Dec 31, 2016

A combination of piperine and ferulic acid might be an alternative therapy in the treatment of psychiatric disorders with high efficacy and low side effects.Jul 29, 2015

A combination of pomegranate, date fruit and date seeds led to a more potent treatment result than each alone. Mar 25, 2015

A combination of resveratrol and curcumin is effective against aluminum chloride-induced neuroinflammation in rats.Feb 06, 2017

A curcumin-artemisinin combination is effective for malaria. May 01, 2006

A diet containing a mixture of P. montana and red ginseng extracts reversed learning and memory impairments.Jul 31, 2018

A ketogenic diet combined with melatonin overcomes cisplatin and vincristine drug resistance in breast carcinoma syngraft.Nov 26, 2019

A quercetin, EGCG and apple polyphenol concentrate improved disorders of lipid metabolism and pro-oxidant-antioxidant homeostasis.Dec 31, 2016

A sea buckthorn and olive oil mixture could be considered as an alternative dressing for full-thickness burns.Jun 30, 2014

A sulfated polysaccharide, fucoidan, enhances the immunomodulatory effects of lactic acid bacteria.Feb 29, 2012

ACE exhibits anti-hyperlipidemia properties and is associated with partially synergistic effects compared with AI or CL alone.Jul 22, 2015

Administration of melatonin and vitamin C as radioprotectors before irradiation may reduce genotoxicity caused by x-ray irradiation.Dec 31, 2015

Administration of vitamins C and E in combination may exert synergistic antinociceptive effects.Dec 31, 2010

Amelioration of oxidative stress by dietary fenugreek seeds is potentiated by onion in streptozotocin-induced diabetic rats.Mar 19, 2017

Andrographis and Hedyotis corymbosa in combination with curcumin have anti-malaria action.Feb 01, 2004

Antioxidants exhibited protective effects against D-galactose-induced oxidative damage in rats.Mar 29, 2016

Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats.Nov 13, 2006

Apple polyphenol extracts might emerge as a promising nutritional ingredient in the management of chronic diseases such as diabetes.Dec 31, 2015

Artemisinin and curcumin inhibit Drosophila brain tumor, prolong life span, and restore locomotor activity.Jun 30, 2014

Natural Substance Synergy

View the Evidence:
474 Abstracts with Natural Substance Synergy Research