Natural Substance/Drug Synergy

Name	AC	CK
Antibiotics	8	28
Fluoxetine (trade name Prozac)	4	24
Methotrexate	1	20
Sertraline	2	20
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	2	11
Acetaminophen	1	10
Antidepressants	1	10
Mesalamine	1	10
Paracetamol	1	10
Simvastatin	1	10
Statin Drugs	1	10
Doxorubicin	2	7
Cisplatin	2	4
Diclofenac	2	4
Indomethacin	2	3
Cadmium	1	2
Fluorouracil (5-FU or f5U)	1	2
Glibenclamide	1	2
Nicotine	1	2
Oseltamivir (trade name Tamiflu)	1	2
Paclitaxel	1	2
Paraquat	1	2
Prednisolone	1	2
Zoledronic Acid	1	2
Aspirin	1	1
Atorvastatin	1	1
Dexamethasone	1	1
Herceptin	1	1

Name	AC	CK
Breast Cancer	66	107
Helicobacter Pylori Infection	16	75
Colorectal Cancer	21	58
Depression	8	56
Rheumatoid Arthritis	8	40
Staphylococcus aureus infection	38	40
Cancers: All	30	35
Alzheimer's Disease	9	34
Liver Cancer	27	34
Escherichia coli Infections	23	32
Gastric Cancer	9	32
Ulcerative Colitis	4	31
Breast Cancer: Triple Negative	21	30
Candida Albicans	28	30
Lung Cancer	23	30
Cancers: Drug Resistant	22	29
Chronic Pain	7	29
Oxidative Stress	12	28
Staphylococcus aureus: Methicillin-resistant (MRSA)	25	28
Pseudomonas aeruginosa	24	27
Colon Cancer	18	25
Infection: Antibiotic Resistant	15	24
Coronavirus Infection	4	23
Ovarian Cancer	7	22
Bacterial Vaginosis	2	20
Depression: Postmenopausal	2	20
Diarrhea: Antibiotic-Associated	1	20
Graves Disease	2	20
High Cholesterol	2	20
Inflammation	13	20
Schizophrenia	2	20
Melanoma	12	16
Epilepsy	4	15
Multiple Myeloma	12	15
Chemotherapy-Induced Toxicity: Cyclophosphamide	3	14
Diabetes Mellitus: Type 2	7	14
Atherosclerosis	3	13
Carcinoma: Non-Small-Cell Lung	10	13
Klebsiella Infections	10	13
Acute lymphoblastic leukemia (ALL)	3	12
Cervical Cancer	7	12
Glioblastoma	11	12
Hepatitis C	3	12
Neuropathic Pain	6	12
Prostate Cancer	10	12
Acinetobacter baumannii infection	8	10
Allergic Rhinitis	1	10
Alopecia	1	10
Anxiety Disorders	1	10
Attention Deficit Disorder with Hyperactivity	1	10
Breast Cancer: Metastatic	1	10
C-Reactive Protein	1	10
Candida Infection	10	10
Cholesterol: High	1	10
Colorectal Adenomas	1	10
Depressive Disorder	1	10
Diabetic Nephropathy	5	10
Drug-Induced Toxicity: Methotrexate	1	10
Fibromyalgia	1	10
Hearing Loss: Sudden	1	10
Leukemia	10	10
Myocarditis: Viral	1	10
Peripheral Arterial Disease	1	10
Polycystic Ovary Syndrome	1	10
Prostatic Hyperplasia	1	10
Prostatitis: Bacterial	1	10
Rett Syndrome	1	10
Salmonella Infections	8	10
Silicosis	1	10
Tinea	1	10
Tonsillitis	1	10
Triglycerides: Elevated	1	10
Upper Respiratory Infections	1	10
Urinary Tract Infections	1	10
Arthritis	5	9
Skin Cancer	6	9
Glioma	6	8
Mycobacterium Tuberculosis	8	8
Sepsis	3	8
Chronic Lymphocytic Leukemia	3	7
Gram-Negative Bacterial Infections	5	7
Hyperglycemia	4	7
Leishmaniasis	4	7
Lipopolysaccharide-Induced Toxicity	2	7
Osteosarcoma	7	7
Pancreatic Cancer	6	7
Allodynia	3	6
Breast Cancer Stem Cells	2	6
Breast Cancer: Drug Resistant	2	6
Esophageal Cancer	4	6
Glioblastoma Multiforme	2	6
Nonalcoholic fatty liver disease (NAFLD)	3	6
Spinal Cord Injuries	3	6
Toxoplasma gondii Infection	3	6
Acute Myeloid Leukemia	5	5
Ebola Virus Infections	1	5
Endothelial Dysfunction	1	5
Hyperalgesia	3	5
Kidney Cancer	5	5
Lymphoma: B-Cell	3	5
Morphine Tolerance/Dependence	3	5
Wound Healing	4	5
Candidiasis	3	4
Diabetic Complications	2	4
Gram-Positive Bacterial Infections	4	4
HIV Infections	4	4
High Fat Diet	2	4
Hyperlipidemia	2	4
Lipid Peroxidation	2	4
Liver Fibrosis	2	4
Malaria	3	4
Malignant Melanoma	2	4
Obesity	2	4
Promyelocytic leukemia	4	4
Seizures	2	4
Seizures: Drug-Induced	2	4
Staphylococcal Infections	2	4
Toxoplasmosis	2	4
Bacterial Infections	3	3
Cachexia: Cancer	2	3
Campylobacter Infections	3	3
Cancer Metastasis	2	3
Cancers: Multi-Drug Resistant	3	3
Candida Glabrata	3	3
Chemotherapy-Induced Toxicity	2	3
Chemotherapy-Induced Toxicity: Bleomycin	2	3
Chemotherapy-Induced Toxicity: Cisplatin	2	3
Chronic Myeloid Leukemia	1	3
Cognitive Decline/Dysfunction	2	3
Cryptococcosis	2	3
Enterococcus Infections	3	3
Hepatitis B	2	3
Leukemia: Chronic Lymphocytic Leukemia (CLL)	1	3
Leukemia: Chronic myelogenous leukemia (CML)	3	3
Lymphoma	2	3
Mastocytosis	1	3
Schistosomiasis	2	3
Staphylococcus epidermidis	3	3
Steptococcus Mutans Infections	3	3
Trypanosomiasis	2	3
Acute T cell Leukemias	2	2
Anxiety	1	2
Aspirin-Induced Toxicity	1	2
Bacillus subtilis infections	2	2
Bladder Cancer	2	2
Burkitt Lymphoma	2	2
Candidiasis: Vulvovaginal	1	2
Cardiotoxicity: Chemotherapy-Induced	1	2
Chagas Disease	1	2
Chemically-Induced Liver Damage	1	2
Chemotherapy	2	2
Chemotherapy and Radiation Toxicity	1	2
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	2
Choriocarcinoma	2	2
Colitis	1	2
Diabetes: Oxidative Stress	1	2
Drug-Induced Toxicity: Indomethacin	1	2
Dyslipidemias	1	2
Ehrlich carcinoma	1	2
Fatty Liver	1	2
Fibrosarcoma	1	2
Fungus Diseases	2	2
Gastric Ulcer	1	2
High Fructose Diet	1	2
Inflammatory Bowel Diseases	1	2
Influenza	1	2
Influenza A	1	2
Insulin Resistance	1	2
Kidney Damage: Chemically-Induced	1	2
Kidney Damage: Drug-Induced	1	2
Klesiella Pneumonia Infection	1	2
Laryngeal Cancer	2	2
Leukemia: Acute myelogenous leukemia (AML)	2	2
Liver Damage: Drug-Induced	1	2
Liver Metastasis From Colon Cancer	1	2
Memory Loss	1	2
Metabolic Diseases	1	2
Mycobacterium abscessus	2	2
Neurodegenerative Diseases	1	2
Osteoarthritis	1	2
Osteomyelitis	1	2
Osteoporosis	1	2
Parasitic Diseases	1	2
Prediabetes	1	2
Respiratory Infections	1	2
Sciatica	1	2
Sleep Disorders	1	2
Squamous cell carcinoma	2	2
Streptococcus Infections	2	2
Traumatic Brain Injury	1	2
Trichinosis	1	2
Tuberculosis Drug Induced Toxicity	1	2
AIDS	1	1
Animal Cancers	1	1
Asthma	1	1
Autoimmune Diseases	1	1
Bacillus Cereus infection	1	1
Bacterial Infections: Resistance/Biofilm Formation	1	1
Bone Cancer	1	1
Brain Cancer	1	1
Brain Inflammation	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Cancer: Pain	1	1
Cancers: Canine	1	1
Carcinosarcomas	1	1
Cardiovascular Disease	1	1
Chemotherapy-Induced Toxicity: Doxorubicin	1	1
Chemotherapy-Induced Toxicity: Tamoxifen	1	1
Cholangiocarcinoma	1	1
Cystic Fibrosis	1	1
Cytomegalovirus Infections	1	1
Dementia	1	1
Diabesity	1	1
Enterobacteriaceae Infections	1	1
Epileptic Seizures	1	1
Fungal Infection	1	1
Fungal Infections: Biofilm Formation/Resistance	1	1
Head and Neck Cancer	1	1
Headache	1	1
Hepatic Steatosis	1	1
Herpes Simplex Virus Type 1	1	1
Herpes Simplex Virus Type 2	1	1
Hypoglycemia	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Lipomucopolysaccharidosis	1	1
Listeria Infections	1	1
Lyme Borreliosis	1	1
Lyme Disease	1	1
Mastitis	1	1
Measles	1	1
Medulloblastoma	1	1
Melanoma: Metastatic	1	1
Memory Disorders	1	1
Multiple Sclerosis	1	1
Mycobacterium Infections	1	1
Nephritis	1	1
Neurofibromatosis	1	1
Non-Hodgkin's lymphoma: B Cell	1	1
Oral Cancer	1	1
Parkinson's Disease	1	1
Periodontal Diseases	1	1
Peripheral Neuropathies	1	1
Radiation Induced Illness	1	1
Retinoblastoma	1	1
Rhabdomyosarcoma	1	1
Schwannoma	1	1
Shigellosis	1	1
Sjogren's Syndrome	1	1
Spondylitis: Ankylosing	1	1
Streptococcus pyogenes	1	1
Tuberculosis: Drug Resistant	1	1

Name	AC	CK
Curcumin	43	118
NAC (N-acetyl-L-cysteine)	9	51
Vitamin C	32	46
Berberine	29	42
EGCG (Epigallocatechin gallate)	22	39
Vitamin D	15	37
Probiotics	5	34
Ginkgo biloba	4	25
Prunella vulgaris	3	25
Ginseng	3	24
Palmitoylethanolamide	4	24
Cannabidiol	11	22
Honeysuckle	2	22
Pomegranate	10	22
Chinese Skullcap	2	21
Resveratrol	11	21
Astragalus	1	20
Cranberry	1	20
Hedyotis corymbosa	1	20
Peony	1	20
Silibinin	10	20
Soy	2	20
Ginsenosides	14	19
Quercetin	16	19
Fucoidan	6	18
Melatonin	8	18
Nigella sativa (aka Black Seed)	4	16
Bee Propolis	5	15
Garlic	6	15
Allicin	5	14
Coenzyme Q10	3	14
Pterostilbene	6	14
Bee Venom	10	13
Cannabis	4	13
Royal Jelly	4	13
Thymoquinone	11	13
Lavender	3	12
Lycopene	2	12
Piperine	8	12
Theanine	2	12
Bromelain	2	11
Echinacea	2	11
Gingerol	5	11
Green Tea	5	11
Honey	2	11
Piperidines	2	11
Acetyl-l-carnitine	1	10
Almond	1	10
Apple Cider Vinegar	1	10
B-complex	1	10
Barberry	1	10
Bee Products	1	10
Bifidobacterium Longum	1	10
Curcuminoids	1	10
Flavonoids	7	10
Flaxseed	1	10
Lactobacillus reuteri	1	10
Mangiferin	8	10
Myrtle	1	10
Naringenin	5	10
Saw Palmetto	1	10
Selenium	1	10
Syrian rue	1	10
Tocotrienol: Delta	1	10
Wogonin	6	10
Parthenolide	8	9
Sulforaphane	8	9
Ursolic Acid	4	9
Carnosic Acid	5	8
Catechin	4	8
Chrysin	5	8
Honokiol	7	8
Oridonin	7	8
Polyphenols	8	8
Ginger	5	7
Luteolin	6	7
Tanshinone IIA	5	7
Baicalein	5	6
Beet	3	6
Genistein	2	6
Indole-3-Carbinol	5	6
Lactoferrin	5	6
Punicalagin	4	6
6-Shogaol	1	5
Amurensin G	1	5
Anthocyanins	3	5
Carrot	2	5
Dandelion	3	5
Deguelin	1	5
Emodin	5	5
Eugenol	3	5
Nordihydroguaiaretic acid (NDGA)	4	5
Plantago major	1	5
Puerarin	3	5
Amygdalin	3	4
Astragaloside	3	4
Beta-Elemene	4	4
Betulinic acid	3	4
Cannabinoids	4	4
Cannabinoids: Synthetic	2	4
Cinnamaldehyde	3	4
Hesperidin	3	4
Licorice	3	4
Magnolol	4	4
Maitake Mushroom	2	4
Olive leaf extract	3	4
Paeoniflorin	3	4
Panax Notoginseng	2	4
Saffron	2	4
Salvia miltiorrhiza	2	4
Turmeric	4	4
Vitamin E: alpha tocopherol	2	4
Artesunate	3	3
Beta-Caryophyllene	2	3
Biochanin A	2	3
Caffeic Acid	3	3
Chlorogenic Acid	2	3
Cinnamon	3	3
Citrus naringin	2	3
Ellagic Acid	2	3
Formononetin	3	3
Gallic Acid	2	3
Guduchi	2	3
Isoflavones	3	3
Mangosteen	2	3
Manuka Honey	3	3
Myricetin	3	3
Nobiletin	2	3
Oleanolic acid	2	3
Oleocanthal	2	3
Organosulfur Compounds	2	3
Phenethyl isothiocyanate	2	3
Piperlongumine	3	3
Propolis: Bee	2	3
Rosmarinic acid	3	3
Seaweed: Brown	2	3
Shikonin	3	3
Tangeretin	3	3
Thymol	3	3
Tomatidine	2	3
Vanillin	3	3
Vitamin B-12	2	3
Vitamin E	2	3
Vitamin E: Gamma-tocotrienol	3	3
Vitamin K	3	3
Wheat Grass	2	3
Zinc	3	3
Achillea fragrantissima	1	2
Allspice	1	2
Aloe Vera	2	2
Alpha-Lipoic Acid	1	2
Andrographolide	2	2
Apigenin	2	2
Arctigenin	2	2
Artemisinin	2	2
Ashwagandha	1	2
Astaxanthin	2	2
Banana	1	2
Basil	2	2
Berbamine	2	2
Beta Sitosterol	1	2
Beta-glucan	1	2
Black Tea	2	2
Bufalin	2	2
Capsaicin	2	2
Chlorella (Algae)	1	2
Chrysanthemum Indicum	1	2
Corn Silk	1	2
Crocin	2	2
Curcumol	2	2
Cyanidin 3-glucoside	1	2
DHA (Docosahexaenoic Acid)	2	2
Devils Claw	1	2
Elecampane	2	2
Evening Primrose Oil	1	2
False Black Pepper	1	2
Ferulic acid	2	2
Feverfew	1	2
Fucoxanthin	2	2
Garlic: Aged	1	2
Genipin	1	2
Geraniol	2	2
Germanium	2	2
Glycyrrhiza uralensis	1	2
Grape Seed Extract	2	2
Grapefruit	1	2
Green Coffee Bean	1	2
Griffithsin	2	2
Holy Basil	1	2
Hyperforin	1	2
Inulin	1	2
Isothiocyanates	2	2
L-Carnitine	1	2
Lactobacillus casei	1	2
Lactobacillus probiotics	1	2
Lactobacillus rhamnosus	1	2
Lemon Balm	1	2
Lemongrass	1	2
Lupeol	1	2
Magnesium	1	2
Mulberry	2	2
Myrrh	1	2
Nettle	1	2
Nisin	2	2
Onion	2	2
Oregano	2	2
Paeonol	2	2
Piceatannol	2	2
Pycnogenol (Pine Bark)	1	2
Resistant Starch	1	2
Rhubarb	1	2
Rooibos	1	2
Rosemaric Acid	1	2
Safflower	1	2
Silver (nanoparticles)	2	2
Silymarin	2	2
Sinomenine	1	2
Spikenard	1	2
Tetrahydrocurcumin	1	2
Thiamine (B-1)	2	2
Tocotrienol: Gamma	1	2
Valerian	1	2
Adlay	1	1
Antrodia cinnamomea	1	1
Asparagus	1	1
Beans: All	1	1
Benzyl isothiocyanate	1	1
Bergamot orange	1	1
Beta-sesquiphellandrene	1	1
Betel	1	1
Bitter Melon	1	1
Bixin	1	1
Black Currant	1	1
Black Raspberry	1	1
Blueberry	1	1
Breast Milk	1	1
Buckwheat	1	1
Burdock	1	1
Cafestol	1	1
Caffeic acid phenethyl ester	1	1
Carnosol	1	1
Carvacrol	1	1
Catechols	1	1
Cayenne	1	1
Celastrol	1	1
Celery seed	1	1
Chia	1	1
Chokeberry	1	1
Citral	1	1
Cruciferous Vegetables	1	1
Cucurbitacin B	1	1
Delta-tetrahydrocannabinol (THC)	1	1
Demethoxycurcumin	1	1
Diosmin	1	1
Epicatechin	1	1
Erucin	1	1
Feijoa	1	1
Fennel	1	1
Folic Acid	1	1
Fruit: All	1	1
Galbanic Acid	1	1
Geranium	1	1
Ginseng (Korean)	1	1
Glycyrrhizin	1	1
Goji	1	1
Gold (nanoparticles)	1	1
Grape	1	1
Haritaki (Terminalia chebula)	1	1
Harmine	1	1
Hibiscus sabdariffa	1	1
Homeopathic Medicine: All	1	1
Honeybush	1	1
Horse Chestnut	1	1
Iodine	1	1
Isomangiferin	1	1
Isoquercitrin	1	1
Kaempferol	1	1
Kudzu	1	1
L-arginine	1	1
Lactobacillus plantarum	1	1
Lichens	1	1
Lotus	1	1
Lutein	1	1
Magnolia	1	1
Maple Syrup	1	1
Modified Arabinoxylan Rice Bran (MGN-3)	1	1
Modified Citrus Pectin	1	1
Moringa oleifera	1	1
Neem	1	1
Oleuropein	1	1
Olive	1	1
Patchouli	1	1
Pelargonium graveolens	1	1
Peppermint	1	1
Perilla	1	1
Phellinus Linteus	1	1
Phloretin	1	1
Plum	1	1
Pyrogallol	1	1
Reishi Mushroom	1	1
Riboflavin (Vitamin B-2)	1	1
Rice Bran	1	1
Rosemary	1	1
Rutin	1	1
Saikosaponin	1	1
Sea buckthorn	1	1
Seaweed	1	1
Sesamol	1	1
Tannic Acid	1	1
Theaflavins	1	1
Thyme	1	1
Tocotrienols	1	1
Tomato	1	1
Tripterygium wilfordii	1	1
Vegetables: All	1	1
Verbascoside	1	1
Vitamin A	1	1
Vitamin B-6	1	1
Vitamin C: Intravenous	1	1
Vitamin K2	1	1
Water: Deuterium Depleted	1	1
Watercress	1	1
White Tea	1	1
beta-Carotene	1	1

Name	AC	CK
Exercise	1	10
Microbiota Transfer Therapy	1	10
Integrative Medicine	2	3

Name	AC	CK
Antiproliferative	153	195
Apoptotic	152	194
Anti-Bacterial Agents	116	189
Chemosensitizer	93	145
Anti-Inflammatory Agents	54	137
Chemotherapeutic	77	128
Antioxidants	48	123
Antiviral Agents	19	59
Gastrointestinal Agents	14	57
Antidepressive Agents	8	56
Antimicrobial	42	52
Chemoprotective Agents	19	52
Hepatoprotective	13	52
Analgesics	14	48
Tumor Necrosis Factor (TNF) Alpha Inhibitor	14	48
Anti-metastatic	33	45
Neuroprotective Agents	16	45
Antineoplastic Agents	35	44
Cell cycle arrest	32	40
Antifungal Agents	24	35
NF-kappaB Inhibitor	22	34
Gastroprotective	9	32
Hypoglycemic Agents	13	31
Immunomodulatory	20	30
Hypolipidemic	6	28
Interleukin-6 Downregulation	12	25
Renoprotective	13	25
Chemopreventive	14	23
Interleukin-1 beta downregulation	9	22
Anticholesteremic Agents	3	21
Anticonvulsants	7	21
Bcl-2 protein down-regulation	11	18
Angiogenesis Inhibitors	13	17
Cyclooxygenase 2 Inhibitors	12	17
Cardioprotective	5	16
Matrix metalloproteinase-9 (MMP-9) inhibitor	10	15
Antinoceceptive	7	14
Interleukin-8 downregulation	4	13
Vascular Endothelial Growth Factor Inhibitors	9	13
Anti-Angiogenic	8	12
Autophagy Up-regulation	6	11
Anti-atherogenic	1	10
Antiparasitic Agents	6	10
Insulin Sensitizers	1	10
Matrix metalloproteinase-2 (MMP-2) inhibitor	7	10
MicroRNA modulator	8	9
Anti-Ulcer Agents	4	8
Cyclin D1 Down-Regulation	3	8
Anti-Tumor	2	7
Leishmanicidal	4	7
Anti-Fibrotic	3	6
Malondialdehyde Down-regulation	3	6
Nrf2 activation	4	6
Anti-Retroviral Agents	1	5
Superoxide Dismutase Up-regulation	3	5
Tumor Suppressor Protein p53 Upregulation	5	5
Anticarcinogenic Agents	4	4
Brain-derived neurotrophic factor modulator	2	4
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	2	4
Interleukin-10 upregulation	2	4
Interleukin-12 upregulation	2	4
Osteoprotective	2	4
P21 Activation	3	4
Radiosensitizer	3	4
Anti-HIV Agents	3	3
Cyclooxygenase Inhibitors	2	3
Immunostimulatory	1	3
Vascular Endothelial Growth Factor A Inhibitor	2	3
AKT-mammalian target of rapamycin (mTOR) pathway inhibitor	1	2
Acetylcholinesterase Inhibitor	1	2
Alpha-glucosidase inhibitor	2	2
Angiogenesis Inducing Agents	1	2
Anthelmintics	1	2
Anti-Anxiety Agents	1	2
Anti-Apoptotic	2	2
Anti-Cachexic Agents	1	2
Catalase Up-Regulation	1	2
Cyclooxygenase 1 Inhibitor	1	2
Cytotoxic	2	2
Hypnotics and Sedatives	1	2
Interferon Gamma Reducer	1	2
Interleukin-10 downregulation	1	2
Interleukin-17 downregulation	1	2
Interleukin-4 downregulation	1	2
Multidrug Resistance Gene Modulators	2	2
Nitric Oxide Enhancer	1	2
Pancreato Protective Agents	1	2
Quorum Sensing Inhibition	2	2
Radioprotective	2	2
STAT3 Inhibitor	2	2
Survivin Down-Regulation	2	2
Vascular Endothelial Growth Factor C Inhibitor	1	2
Wnt/β-catenin signaling pathway modulation	2	2
apoptosis	1	2
Anti-Asthmatic Agents	1	1
Antimalarials	1	1
Appetite Stimulants	1	1
Bcl-xL down-regulation	1	1
Heat Shock Protein Inducer	1	1
Histone deacetylase inhibitor	1	1
Interleukin-12 downregulation	1	1
Interleukin-23 Downregulation	1	1
Photoprotective	1	1
Postaglandin PGE2 downregulation	1	1
Reactive Oxygen Species (ROS) attenuation	1	1
Reverse Transcriptase Inhibitors	1	1
SIRT1 Activator	1	1

[+]

Ginkgo biloba preparations plus donepezil can improve clinical effectiveness rate and vocabulary memory outcomes.Dec 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Aging Neurosci. 2023 ;15:1124710. Epub 2023 Mar 7. PMID: 36960422

Article Published Date : Dec 31, 2022

Study Type : Meta Analysis, Review

Additional Links

Substances : Ginkgo biloba

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Ginseng-containing traditional medicine preparations in combination with fluoropyrimidine-based chemotherapy for advanced gastric cancer.Dec 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2023 ;18(4):e0284398. Epub 2023 Apr 17. PMID: 37068063

Article Published Date : Dec 31, 2022

Study Type : Meta Analysis, Review

Additional Links

Substances : Ginseng

Diseases : Gastric Cancer

Pharmacological Actions : Chemoprotective Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

A review of the beneficial effects of antioxidants on Helicobacter pylori eradication.Nov 30, 2018

Click here to read the entire abstract

Pubmed Data : Helicobacter. 2018 Dec ;23(6):e12535. Epub 2018 Sep 6. PMID: 30191635

Article Published Date : Nov 30, 2018

Study Type : Meta Analysis, Review

Additional Links

Substances : Cranberry, Curcumin, NAC (N-acetyl-L-cysteine)

Diseases : Helicobacter Pylori Infection

Pharmacological Actions : Anti-Bacterial Agents, Antioxidants

Additional Keywords : Natural Substance/Drug Synergy

[+]

Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Des Devel Ther. 2019 ;13:1969-1984. Epub 2019 Jun 17. PMID: 31354242

Article Published Date : Dec 31, 2018

Study Type : Meta Analysis

Additional Links

Substances : Peony

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Methotrexate

[+]

Honeysuckle combined with conventional therapy may be beneficial for the treatment of COVID-19 in improving lung CT, clinical cure rate, clinical symptoms.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2021 ;12:708636. Epub 2021 Sep 15. PMID: 34603023

Article Published Date : Dec 31, 2020

Study Type : Meta Analysis, Review

Additional Links

Substances : Honeysuckle

Diseases : Coronavirus Infection

Pharmacological Actions : Antiviral Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Specific combinations of traditional medicines appeared to produce higher contributions to tumor response rate than the TMs individually.Aug 05, 2015

Click here to read the entire abstract

Pubmed Data : Integr Cancer Ther. 2015 Aug 6. Epub 2015 Aug 6. PMID: 26254190

Article Published Date : Aug 05, 2015

Study Type : Meta Analysis

Additional Links

Substances : Astragalus, Chinese Skullcap , Hedyotis corymbosa

Diseases : Colorectal Cancer

Additional Keywords : Drug: Oxaliplatin, Natural Substance/Drug Synergy

[+]

The addition of probiotics to standard therapy is associated with improved H. pylori eradication rates in both children and adults.Dec 31, 2015

Click here to read the entire abstract

Pubmed Data : Infect Drug Resist. 2016 ;9:275-289. Epub 2016 Dec 7. PMID: 27994474

Article Published Date : Dec 31, 2015

Study Type : Meta Analysis

Additional Links

Substances : Probiotics

Diseases : Diarrhea: Antibiotic-Associated, Helicobacter Pylori Infection

Pharmacological Actions : Gastroprotective

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Antibiotics

[+]

Bee products are effective in symptomatic treatment of upper respiratory tract infections.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Turk J Pediatr. 2020 ;62(4):634-640. PMID: 32779416

Article Published Date : Dec 31, 2019

Study Type : Human Study

Additional Links

Substances : Bee Products, Bee Propolis, Honey, Royal Jelly

Diseases : Upper Respiratory Infections

Pharmacological Actions : Anti-Bacterial Agents, Antiviral Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Probiotic Bifidobacterium longum supplied with methimazole improved the thyroid function of Graves' disease patients through the gut-thyroid axis Jan 06, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Commun Biol. 2021 09 7 ;4(1):1046. Epub 2021 Sep 7. PMID: 34493790

Article Published Date : Jan 06, 2021

Study Type : Human Study

Additional Links

Substances : Bifidobacterium Longum

Diseases : Graves Disease

Pharmacological Actions : Gastrointestinal Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

"Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer."Feb 28, 2011

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Lett. 2011 Mar ;2(2):319-322. Epub 2011 Jan 21. PMID: 22866084

Article Published Date : Feb 28, 2011

Study Type : Human Study

Additional Links

Substances : Fucoidan

Diseases : Colorectal Adenomas

Pharmacological Actions : Chemosensitizer

Additional Keywords : Natural Substance/Drug Synergy

[+]

Adding 100 g of almonds daily to chronic statin therapy for 4 weeks significantly reduced non-HDL-C.Dec 31, 2014

Click here to read the entire abstract

Pubmed Data : J Clin Lipidol. 2015 ;9(1):58-64. Epub 2014 Oct 13. PMID: 25670361

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Substances : Almond

Diseases : High Cholesterol

Pharmacological Actions : Anticholesteremic Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Adding Berberis vulgaris fruit extract on metronidazole improve the efficacy of bacterial vaginosis therapy.Jul 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Electron Physician. 2016 Aug ;8(8):2818-2827. Epub 2016 Aug 25. PMID: 27757195

Article Published Date : Jul 31, 2016

Study Type : Human Study

Additional Links

Substances : Barberry

Diseases : Bacterial Vaginosis

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Adding M. communis extract to metronidazole increases the efficiency of bacterial vaginosis treatment.Feb 28, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Avicenna J Phytomed. 2017 Mar-Apr;7(2):129-136. PMID: 28348968

Article Published Date : Feb 28, 2017

Study Type : Human Study

Additional Links

Substances : Myrtle

Diseases : Bacterial Vaginosis

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Addition of epigallocatechin gallate 400 mg to sofosbuvir 400 mg + daclatisvir 60 mg in in treatment of patients with chronic hepatitis C.Jan 18, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2019 09 19 ;9(1):13593. Epub 2019 Sep 19. PMID: 31537880

Article Published Date : Jan 18, 2019

Study Type : Human Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Hepatitis C

Pharmacological Actions : Antiviral Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Adjuvant palmitoylethanolamide therapy with risperidone improves negative symptoms in patients with schizophrenia.Sep 30, 2022

Click here to read the entire abstract

Pubmed Data : Psychiatry Res. 2022 Oct ;316:114737. Epub 2022 Jul 27. PMID: 35917650

Article Published Date : Sep 30, 2022

Study Type : Human Study

Additional Links

Substances : Palmitoylethanolamide

Diseases : Schizophrenia

Additional Keywords : Natural Substance/Drug Synergy

[+]

Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection.Nov 20, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : World J Gastroenterol. 2012 Nov 21 ;18(43):6302-7. PMID: 23180952

Article Published Date : Nov 20, 2012

Study Type : Human Study

Additional Links

Substances : Probiotics

Diseases : Helicobacter Pylori Infection

Additional Keywords : Natural Substance/Drug Synergy

[+]

Antimicrobial activity of Prunella Vulgaris extracts against multi-drug resistant Escherichia Coli from patients of urinary tract infection.Apr 30, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pak J Med Sci. 2018 May-Jun;34(3):616-620. PMID: 30034426

Article Published Date : Apr 30, 2018

Study Type : Human In Vitro, Human Study

Additional Links

Substances : Prunella vulgaris

Diseases : Escherichia coli Infections, Infection: Antibiotic Resistant, Urinary Tract Infections

Pharmacological Actions : Antimicrobial

Additional Keywords : Natural Substance/Drug Synergy

[+]

Application of Peganum harmala seed can be useful in reducing urinary symptoms in patients with benign prostatic hyperplasia.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Renal Inj Prev. 2017 ;6(2):127-131. Epub 2016 Dec 18. PMID: 28497089

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Substances : Syrian rue

Diseases : Prostatic Hyperplasia

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

Additional Keywords : Natural Substance/Drug Synergy

[+]

Black cumin seeds decreased Methotrexate hepatotoxicity and improved survival in children with ALLMar 19, 2015

Click here to read the entire abstract

Pubmed Data : Infect Disord Drug Targets. 2015 Mar 20. Epub 2015 Mar 20. PMID: 25809628

Article Published Date : Mar 19, 2015

Study Type : Human Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Acute lymphoblastic leukemia (ALL), Drug-Induced Toxicity: Methotrexate

Pharmacological Actions : Chemotherapeutic, Hepatoprotective

Additional Keywords : Natural Substance/Drug Synergy

[+]

Cannabis users report greater pain relief in combination with opioids than when opioids are used alone.Jan 31, 2015

Click here to read the entire abstract

Pubmed Data : Drug Alcohol Depend. 2015 Feb 1 ;147:144-50. Epub 2014 Dec 10. PMID: 25533893

Article Published Date : Jan 31, 2015

Study Type : Human Study

Additional Links

Substances : Cannabis

Diseases : Chronic Pain

Pharmacological Actions : Analgesics

Additional Keywords : Natural Substance/Drug Synergy

[+]

Clinical efficacy of acetylcysteine combined with tetrandrine tablets on patients with silicosis.Jul 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Ther Med. 2020 Aug ;20(2):1285-1290. Epub 2020 Jun 10. PMID: 32765668

Article Published Date : Jul 31, 2020

Study Type : Human Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Silicosis

Therapeutic Actions : Exercise

Additional Keywords : Natural Substance/Drug Synergy

[+]

Curcumin could reverse the development of depression and enhance the outcome of antidepressants treatment in major depressive disorder.Jul 31, 2015

Click here to read the entire abstract

Pubmed Data : J Clin Psychopharmacol. 2015 Aug ;35(4):406-10. PMID: 26066335

Article Published Date : Jul 31, 2015

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Depression

Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance/Drug Synergy, Significant Treatment Outcome

Problem Substances : Antidepressants

[+]

Curcumin may be a safe and effective therapy for maintenance of remission in quiescent UC when given as adjunctive therapy along with mesalamine or sulfasalazine. Dec 31, 2011

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cochrane Database Syst Rev. 2012 ;10:CD008424. Epub 2012 Oct 17. PMID: 23076948

Article Published Date : Dec 31, 2011

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Ulcerative Colitis

Additional Keywords : Complementary Alternative Medicine, Natural Substance/Drug Synergy, Randomized Controlled Trials As Topic

Problem Substances : Mesalamine, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Curcuminoids with piperine may be used as a safe and effective add on to standard antidepressants in patients with major depressive disorders.Dec 31, 2014

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2015 Jan ;29(1):17-21. Epub 2014 Aug 4. PMID: 25091591

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Substances : Curcumin, Piperidines

Diseases : Anxiety Disorders, Depression, Depressive Disorder

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Effective analgesic between acetominophen + B vitamins vs. acetominophen in pediatric ambulatory surgery.Dec 31, 2009

Click here to read the entire abstract

Pubmed Data : Cir Cir. 2010 ;78(5):400-9. PMID: 21219810

Article Published Date : Dec 31, 2009

Study Type : Human Study

Additional Links

Substances : B-complex

Diseases : Chronic Pain

Pharmacological Actions : Analgesics

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Acetaminophen, Paracetamol

[+]

Efficacy and tolerance of cannabidiol in the treatment of epilepsy in patients with Rett syndrome.Jul 23, 2023

Click here to read the entire abstract

Pubmed Data : Epilepsia Open. 2023 Jul 24. Epub 2023 Jul 24. PMID: 37485779

Article Published Date : Jul 23, 2023

Study Type : Human Study

Additional Links

Substances : Cannabidiol

Diseases : Epilepsy, Rett Syndrome

Pharmacological Actions : Anticonvulsants

Additional Keywords : Natural Substance/Drug Synergy

[+]

Fecal microbiota transplantation plus tislelizumab and fruquintinib in refractory microsatellite stable metastatic colorectal cancer.Nov 30, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : EClinicalMedicine. 2023 Dec ;66:102315. Epub 2023 Nov 14. PMID: 38024475

Article Published Date : Nov 30, 2023

Study Type : Human Study

Additional Links

Diseases : Colorectal Cancer

Therapeutic Actions : Microbiota Transfer Therapy

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Helicobacter pylori eradication: Sequential therapy and Lactobacillus reuteri supplementation.Nov 20, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : World J Gastroenterol. 2012 Nov 21 ;18(43):6250-4. PMID: 23180945

Article Published Date : Nov 20, 2012

Study Type : Human Study

Additional Links

Substances : Lactobacillus reuteri

Diseases : Helicobacter Pylori Infection

Additional Keywords : Natural Substance/Drug Synergy

[+]

L-Theanine adjunct to risperidone in the treatment of chronic schizophrenia inpatients.Nov 30, 2023

Click here to read the entire abstract

Pubmed Data : Psychopharmacology (Berl). 2023 Dec ;240(12):2631-2640. Epub 2023 Sep 12. PMID: 37697164

Article Published Date : Nov 30, 2023

Study Type : Human Study

Additional Links

Substances : Theanine

Diseases : Schizophrenia

Additional Keywords : Natural Substance/Drug Synergy

[+]

Lavandula angustifilia infusion has some positive therapeutic effects on depressed patients most importantly decreases mean depression score and might be used alone or as an adjunct to other anti-depressant drugs.Jul 31, 2013

Click here to read the entire abstract

Pubmed Data : Iran Red Crescent Med J. 2013 Aug ;15(8):734-9. Epub 2013 Aug 5. PMID: 24578844

Article Published Date : Jul 31, 2013

Study Type : Human Study

Additional Links

Substances : Lavender

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Milled flaxseed lowers total and LDL cholesterol in patients with peripheral artery disease.Mar 31, 2015

Click here to read the entire abstract

Pubmed Data : J Nutr. 2015 Apr ;145(4):749-57. Epub 2015 Feb 18. PMID: 25694068

Article Published Date : Mar 31, 2015

Study Type : Human Study

Additional Links

Substances : Flaxseed

Diseases : Cholesterol: High, Peripheral Arterial Disease

Pharmacological Actions : Anticholesteremic Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

N-acetylcysteine combined with dexamethasone treatment improves sudden sensorineural hearing loss.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Cell Dev Biol. 2021 ;9:659486. Epub 2021 Mar 18. PMID: 33816510

Article Published Date : Dec 31, 2020

Study Type : Human Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Hearing Loss: Sudden

Pharmacological Actions : Antioxidants

Additional Keywords : Natural Substance/Drug Synergy

[+]

Novel bioenhanced curcumin with mesalamine for induction of clinical and endoscopic remission in mild-to-moderate ulcerative colitis.Aug 31, 2021

Click here to read the entire abstract

Pubmed Data : J Clin Gastroenterol. 2021 Sep 1 ;55(8):702-708. PMID: 32889959

Article Published Date : Aug 31, 2021

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Ulcerative Colitis

Pharmacological Actions : Gastrointestinal Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Palmitoylethanolamide and acetyl-L-carnitine act synergistically with duloxetine and pregabalin in fibromyalgia.May 31, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Clin Exp Rheumatol. 2023 Jun ;41(6):1323-1331. Epub 2023 Jun 28. PMID: 37378482

Article Published Date : May 31, 2023

Study Type : Human Study

Additional Links

Substances : Acetyl-l-carnitine, Palmitoylethanolamide

Diseases : Fibromyalgia

Pharmacological Actions : Analgesics

Additional Keywords : Natural Substance/Drug Synergy

[+]

Preparation and optimization of garlic oil/apple vider vinegar nanoemulsion loaded with minoxidil to treat alopecia.Dec 13, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmaceutics. 2021 Dec 14 ;13(12). Epub 2021 Dec 14. PMID: 34959435

Article Published Date : Dec 13, 2021

Study Type : Human Study

Additional Links

Substances : Apple Cider Vinegar, Garlic

Diseases : Alopecia

Additional Keywords : Natural Substance/Drug Synergy

[+]

Prunella vulgaris may be a potential adjuvant medicine for breast cancer treatment.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2018 ;9:806. Epub 2018 Aug 3. PMID: 30123125

Article Published Date : Dec 31, 2017

Study Type : Human Study

Additional Links

Substances : Prunella vulgaris

Diseases : Breast Cancer

Pharmacological Actions : Chemoprotective Agents, Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Resveratrol adjunct to methylphenidate improves symptoms of attention-deficit/hyperactivity disorder.Apr 30, 2021

Click here to read the entire abstract

Pubmed Data : Eur Child Adolesc Psychiatry. 2021 May ;30(5):799-807. Epub 2020 May 24. PMID: 32449130

Article Published Date : Apr 30, 2021

Study Type : Human Study

Additional Links

Substances : Resveratrol

Diseases : Attention Deficit Disorder with Hyperactivity

Additional Keywords : Natural Substance/Drug Synergy

[+]

Silibinin may improve the effects of methotrexate on certain biochemical and clinical markers of patients with active rheumatoid arthritis.Jun 30, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oman Med J. 2016 Jul ;31(4):263-9. PMID: 27403238

Article Published Date : Jun 30, 2016

Study Type : Human Study

Additional Links

Substances : Silibinin

Diseases : C-Reactive Protein, Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

Somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide led to an overall clinical benefit been achieved in 75% of cases.Dec 31, 2012

Click here to read the entire abstract

Pubmed Data : Neuro Endocrinol Lett. 2013 ;34(7):660-8. PMID: 24464005

Article Published Date : Dec 31, 2012

Study Type : Human Study

Additional Links

Substances : Melatonin, Vitamin D

Diseases : Breast Cancer, Breast Cancer: Metastatic, Chemotherapy-Induced Toxicity: Cyclophosphamide

Additional Keywords : Natural Substance/Drug Synergy, Significant Treatment Outcome

[+]

Synergism of allicin in combination with itraconazole and terbinafine, which could be a reference for the treatment of tinea capitis due to M. canis.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Med (Lausanne). 2021 ;8:783086. Epub 2021 Nov 26. PMID: 34901093

Article Published Date : Dec 31, 2020

Study Type : Human Study

Additional Links

Substances : Allicin

Diseases : Tinea

Pharmacological Actions : Antifungal Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

The addition of POMx to simvastatin therapy in hypercholesterolemic patients improved oxidative stress and lipid status in the patient's serum and in their HMDM. Dec 31, 2013

Click here to read the entire abstract

Pubmed Data : Atherosclerosis. 2014 Jan ;232(1):204-10. Epub 2013 Nov 19. PMID: 24401239

Article Published Date : Dec 31, 2013

Study Type : Human Study

Additional Links

Substances : Pomegranate

Diseases : Atherosclerosis, High Cholesterol, Oxidative Stress, Triglycerides: Elevated

Pharmacological Actions : Anti-atherogenic, Antioxidants, Hypolipidemic

Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts

Problem Substances : Simvastatin, Statin Drugs

[+]

The administration of soybean could enhance the response to SSRI anti depressants in menopausal women.Feb 28, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Acta Pol Pharm. 2014 Mar-Apr;71(2):323-7. PMID: 25272653

Article Published Date : Feb 28, 2014

Study Type : Human Study

Additional Links

Substances : Soy

Diseases : Depression, Depression: Postmenopausal

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Fluoxetine (trade name Prozac) , Sertraline

[+]

The administration of soybean could enhance the response to SSRI anti depressants in menopausal women.Feb 28, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Acta Pol Pharm. 2014 Mar-Apr;71(2):323-7. PMID: 25272653

Article Published Date : Feb 28, 2014

Study Type : Human Study

Additional Links

Substances : Soy

Diseases : Depression, Depression: Postmenopausal

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Fluoxetine (trade name Prozac) , Sertraline

[+]

The combination of bevacizumab and tocotrienol is potent in chemotherapy refractory ovarian cancer. Feb 28, 2019

Click here to read the entire abstract

Pubmed Data : Pharmacol Res. 2019 Mar ;141:392-396. Epub 2019 Jan 9. PMID: 30639384

Article Published Date : Feb 28, 2019

Study Type : Human Study

Additional Links

Substances : Tocotrienol: Delta

Diseases : Ovarian Cancer

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

[+]

The combination of serenoa repens, selenium, lycopene and bromelain are beneficial in patients with chronic bacterial prostatitis.Oct 04, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Arch Ital Urol Androl. 2016 Oct 5 ;88(3):177-182. Epub 2016 Oct 5. PMID: 27711089

Article Published Date : Oct 04, 2016

Study Type : Human Study

Additional Links

Substances : Bromelain, Lycopene, Saw Palmetto, Selenium

Diseases : Prostatitis: Bacterial

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts

[+]

The combined use of echinacea with azithromycin produced favourable outcome than azithromycin alone in pediatric patients with recurrent tonsillitis.Jul 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Otolaryngol. 2020 Jul - Aug;41(4):102344. Epub 2019 Nov 12. PMID: 32487336

Article Published Date : Jul 31, 2020

Study Type : Human Study

Additional Links

Substances : Echinacea

Diseases : Tonsillitis

Additional Keywords : Natural Substance/Drug Synergy

[+]

The effect of coenzyme Q10 plus trimetazidine on acute viral myocarditis treatment.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Transl Res. 2021 ;13(12):13854-13861. Epub 2021 Dec 15. PMID: 35035725

Article Published Date : Dec 31, 2020

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10

Diseases : Myocarditis: Viral

Pharmacological Actions : Cardioprotective

Additional Keywords : Natural Substance/Drug Synergy

[+]

The efficacy of curcuminoids in improvement of ulcerative colitis symptoms and patients' self-reported well-being.Oct 31, 2018

Click here to read the entire abstract

Pubmed Data : J Cell Biochem. 2018 Nov ;119(11):9552-9559. Epub 2018 Aug 21. PMID: 30132960

Article Published Date : Oct 31, 2018

Study Type : Human Study

Additional Links

Substances : Curcuminoids

Diseases : Ulcerative Colitis

Pharmacological Actions : Gastrointestinal Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

The potential prebiotic berberine combined with methimazole improved the therapeutic effect of Graves' disease patients.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Immunol. 2021 ;12:826067. Epub 2022 Jan 10. PMID: 35082799

Article Published Date : Dec 31, 2020

Study Type : Human Study

Additional Links

Substances : Berberine

Diseases : Graves Disease

Pharmacological Actions : Gastrointestinal Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Therapeutic effect of curcumin in women with polycystic ovary syndrome receiving metformin.Dec 31, 2020

Click here to read the entire abstract

Pubmed Data : Adv Exp Med Biol. 2021 ;1308:109-117. PMID: 33861440

Article Published Date : Dec 31, 2020

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Polycystic Ovary Syndrome

Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic, Insulin Sensitizers

Additional Keywords : Natural Substance/Drug Synergy

[+]

Vitamin D supplementation improves the therapeutic effect of mometasone on allergic rhinitis.Sep 15, 2023

Click here to read the entire abstract

Pubmed Data : Acta Biochim Pol. 2023 Sep 16 ;70(3):583-589. PMID: 37716008

Article Published Date : Sep 15, 2023

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Allergic Rhinitis

Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

6-shogaol, 6-gingerol and pterostilbene selectively killed breast cancer stem cells.Mar 10, 2015

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2015 Mar 11 ;63(9):2432-41. Epub 2015 Feb 25. PMID: 25686711

Article Published Date : Mar 10, 2015

Study Type : Human In Vitro

Additional Links

Substances : 6-Shogaol, Gingerol , Pterostilbene

Diseases : Breast Cancer, Breast Cancer Stem Cells

Pharmacological Actions : Chemosensitizer, Cyclin D1 Down-Regulation

Additional Keywords : Natural Substance/Drug Synergy

[+]

Amurensin G. was a potent SIRT1 Inhibitor which led to the down regulation of multidrug resistance.Oct 31, 2010

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Pharmacol. 2010 Nov ;78(5):855-64. Epub 2010 Aug 16. PMID: 20713551

Article Published Date : Oct 31, 2010

Study Type : Animal Study, Human In Vitro

Additional Links

Substances : Amurensin G

Diseases : Breast Cancer: Drug Resistant, Cancers: Drug Resistant

Pharmacological Actions : Chemosensitizer

Additional Keywords : Gene Expression Regulation, Natural Substance/Drug Synergy, Plant Extracts

Problem Substances : Doxorubicin

[+]

Combinations of EGCG and anticancer compounds induced synergistic anticancer effects in vitro and in vivo experiments, and showed an average reduction in tumor volume by 70.3 %.Aug 31, 2015

Click here to read the entire abstract

Pubmed Data : J Cancer Res Clin Oncol. 2015 Sep ;141(9):1511-22. Epub 2014 Dec 28. PMID: 25544670

Article Published Date : Aug 31, 2015

Study Type : Animal Study, Human In Vitro

Additional Links

Substances : Catechin , EGCG (Epigallocatechin gallate), Green Tea

Diseases : Cancers: All

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Cancer Stem Cells, Natural Substance/Drug Synergy

[+]

Findings suggest that Plantago ovata husk could be a potentially useful adjuvant in chemotherapy for colorectal cancer.Jun 01, 2012

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Pubmed Data : Br J Nutr. 2012 Jun ;107(11):1591-602. Epub 2011 Sep 29. PMID: 22018732

Article Published Date : Jun 01, 2012

Study Type : Human In Vitro

Additional Links

Substances : Plantago major

Diseases : Colorectal Cancer

Additional Keywords : Natural Substance/Drug Synergy

[+]

Hydrocortisone and ascorbic acid synergistically prevent and repair lipopolysaccharide-induced pulmonary endothelial barrier dysfunction.Jan 10, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Chest. 2017 11 ;152(5):954-962. Epub 2017 Jul 21. PMID: 28739448

Article Published Date : Jan 10, 2017

Study Type : Human In Vitro

Additional Links

Substances : Vitamin C

Diseases : Endothelial Dysfunction, Lipopolysaccharide-Induced Toxicity, Sepsis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

Additional Keywords : Natural Substance/Drug Synergy

[+]

Piperine enhanced mitomycin-C therapy in human cervical cancer cells.Nov 19, 2017

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2017 Nov 20. Epub 2017 Nov 20. PMID: 29169726

Article Published Date : Nov 19, 2017

Study Type : Human In Vitro

Additional Links

Substances : Piperine

Diseases : Cervical Cancer

Pharmacological Actions : Bcl-2 protein down-regulation, Chemosensitizer

Additional Keywords : Natural Substance/Drug Synergy

[+]

Prunella vulgaris has potent anti-Ebola virus activity and may be developed as a novel antiviral approach against EBOV infection.Feb 29, 2016

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Pubmed Data : Antiviral Res. 2016 Mar ;127:20-31. Epub 2016 Jan 9. PMID: 26778707

Article Published Date : Feb 29, 2016

Study Type : Human In Vitro

Additional Links

Substances : Prunella vulgaris

Diseases : Ebola Virus Infections

Pharmacological Actions : Anti-Retroviral Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Pterostilbene might be used to modulate two anticancer compounds in well-defined sets of GBM patients.Nov 07, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2016 Nov 8 ;7(45):73200-73215. PMID: 27689322

Article Published Date : Nov 07, 2016

Study Type : Human In Vitro

Additional Links

Substances : Pterostilbene

Diseases : Glioblastoma Multiforme

Pharmacological Actions : Antiproliferative , Cell cycle arrest, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Gefitinib, Natural Substance/Drug Synergy

[+]

The combination of centchroman with genistein has selective cytotoxic effect for human breast cancer cell lines.Oct 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Indian J Pharmacol. 2016 Nov-Dec;48(6):637-642. PMID: 28066099

Article Published Date : Oct 31, 2016

Study Type : Human In Vitro

Additional Links

Substances : Genistein

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Chemosensitizer

Additional Keywords : Breast Cancer, Breast Cancer: Triple Negative, Chemosensitizer, Genistein, Natural Substance/Drug Synergy, Selective Cytotoxicity

[+]

These results suggest deguelin could have potential for the treatment of human CLL.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2016 ;11(4):e0154159. Epub 2016 Apr 21. PMID: 27101369

Article Published Date : Dec 31, 2015

Study Type : Animal Study, Human In Vitro

Additional Links

Substances : Deguelin

Diseases : Chronic Lymphocytic Leukemia

Pharmacological Actions : Apoptotic, NF-kappaB Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

Ursolic acid enhances the sensitivity of MCF-7 and MDA-MB-231 cells to epirubicin.May 24, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2022 May 25 ;27(11). Epub 2022 May 25. PMID: 35684339

Article Published Date : May 24, 2022

Study Type : Human In Vitro

Additional Links

Substances : Ursolic Acid

Diseases : Breast Cancer

Pharmacological Actions : Apoptotic, Autophagy Up-regulation, Chemosensitizer

Additional Keywords : Natural Substance/Drug Synergy

[+]

Baicalin acts as an adjuvant to potentiate the activity of azithromycin against Staphylococcus saprophyticus biofilm: an in vitro, in vivo, and molecular study.Oct 11, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Vet Res. 2022 Oct 12 ;53(1):83. Epub 2022 Oct 12. PMID: 36224607

Article Published Date : Oct 11, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Flavonoids

Diseases : Staphylococcal Infections

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation, Natural Substance/Drug Synergy

[+]

Beetroot-carrot juice can be used as an effective treatment for CLL alone or in combination with chlorambucil.Jun 14, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Open Access Maced J Med Sci. 2015 Jun 15 ;3(2):331-6. Epub 2015 Jun 2. PMID: 27275246

Article Published Date : Jun 14, 2015

Study Type : Human: Case Report

Additional Links

Substances : Beet, Carrot

Diseases : Leukemia: Chronic Lymphocytic Leukemia (CLL)

Pharmacological Actions : Chemopreventive, Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Dihydrotanshinone I is effective against drug-resistant Helicobacter pylori.Feb 16, 2021

Click here to read the entire abstract

Pubmed Data : Antimicrob Agents Chemother. 2021 Feb 17 ;65(3). Epub 2021 Feb 17. PMID: 33318002

Article Published Date : Feb 16, 2021

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Salvia miltiorrhiza

Diseases : Helicobacter Pylori Infection

Pharmacological Actions : Anti-Bacterial Agents, Anti-Ulcer Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Eugenol works synergistically with colistin against colistin-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae.Sep 13, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Microbiol Spectr. 2023 Sep 14 ;11(5):e0366622. Epub 2023 Sep 14. PMID: 37707450

Article Published Date : Sep 13, 2023

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Eugenol

Diseases : Klebsiella Infections, Pseudomonas aeruginosa

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Fucoidan enhances the chemotherapeutic sensitivity of capecitabine in colon cancer Sep 24, 2022

Click here to read the entire abstract

Pubmed Data : Int J Biol Macromol. 2022 Sep 25 ;222(Pt A):562-572. Epub 2022 Sep 25. PMID: 36170928

Article Published Date : Sep 24, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Fucoidan

Diseases : Colon Cancer

Pharmacological Actions : Chemosensitizer, Immunostimulatory

Additional Keywords : Natural Substance/Drug Synergy

[+]

In vitro and in vivo synergistic effect of chrysin in combination with colistin against Acinetobacter baumannii.Dec 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Microbiol. 2022 ;13:961498. Epub 2022 Oct 28. PMID: 36386691

Article Published Date : Dec 31, 2021

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Chrysin

Diseases : Acinetobacter baumannii infection

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Naringenin restores colistin activation against colistin-resistant gram-negative bacteria in vitro and in vivo.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Microbiol. 2022 ;13:916587. Epub 2022 Aug 3. PMID: 35992710

Article Published Date : Dec 31, 2021

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Naringenin

Diseases : Gram-Negative Bacterial Infections

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Omalizumab ensures compatibility to bee venom immunotherapy (VIT) after VIT-induced anaphylaxis in a patient with systemic mastocytosis.Dec 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Allergol Select. 2021 ;5:128-132. Epub 2021 Mar 11. PMID: 33733040

Article Published Date : Dec 31, 2020

Study Type : Human: Case Report

Additional Links

Substances : Bee Venom

Diseases : Mastocytosis

Additional Keywords : Natural Substance/Drug Synergy

[+]

Oxidative lipid damage by naringenin selectively sensitizes chronic myeloid leukemia cell lines.Sep 02, 2024

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Pubmed Data : Biochem Biophys Res Commun. 2024 Sep 3 ;733:150653. Epub 2024 Sep 3. PMID: 39278089

Article Published Date : Sep 02, 2024

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Naringenin

Diseases : Chronic Myeloid Leukemia

Pharmacological Actions : Antiproliferative , Chemosensitizer

Additional Keywords : Natural Substance/Drug Synergy

[+]

Synergistic effect of oridonin and a PI3K/mTOR inhibitor on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma.Jan 22, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Hematol Oncol. 2016 08 23 ;9(1):72. Epub 2016 Aug 23. PMID: 27554093

Article Published Date : Jan 22, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Oridonin

Diseases : Lymphoma: B-Cell

Pharmacological Actions : Apoptotic

Additional Keywords : Natural Substance/Drug Synergy

[+]

The combination of Biochanin A and SB590885 potentiates the inhibition of tumour progression in hepatocellular carcinoma.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Cell Int. 2020 ;20:371. Epub 2020 Aug 5. PMID: 32774165

Article Published Date : Dec 31, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Biochanin A

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Natural Substance/Drug Synergy

[+]

The dual roles of ginsenosides in improving the anti-tumor efficiency of cyclophosphamide in mammary carcinoma mice. Aug 23, 2020

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2020 Aug 24:113271. Epub 2020 Aug 24. PMID: 32853742

Article Published Date : Aug 23, 2020

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Breast Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemotherapeutic, Nrf2 activation

Additional Keywords : Natural Substance/Drug Synergy

[+]

3,3'-diindolylmethane plus eflornithine suppress DNA replication and cell cycle in esophageal squamous cell Carcinoma.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Cancer. 2022 ;13(8):2607-2619. Epub 2022 May 16. PMID: 35711839

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Diseases : Esophageal Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Natural Substance/Drug Synergy

[+]

A combination of ascorbate with Amphotericin B is a potentially effective treatment that may reduce nephrotoxicity in patients with systemic candidiasis.Jul 31, 2015

Click here to read the entire abstract

Pubmed Data : Am J Physiol Regul Integr Comp Physiol. 2015 Aug 1 ;309(3):R223-34. PMID: 25994956

Article Published Date : Jul 31, 2015

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Candida Albicans, Candidiasis, Sepsis

Pharmacological Actions : Renoprotective

Additional Keywords : Natural Substance/Drug Synergy

[+]

Achillea fragrantissima, rich in flavonoids and tannins, potentiates the activity of diminazine aceturate against Trypanosoma evansi in rats.Feb 29, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Trop Med. 2016 Mar ;9(3):228-34. Epub 2016 Jan 11. PMID: 26972392

Article Published Date : Feb 29, 2016

Study Type : Animal Study

Additional Links

Substances : Achillea fragrantissima

Diseases : Parasitic Diseases

Pharmacological Actions : Antiparasitic Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Additive antiangiogenesis effect of ginsenoside Rg3 with low-dose metronomic temozolomide on rat glioma cells both in vivo and in vitro.Feb 12, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Exp Clin Cancer Res. 2016 Feb 13 ;35:32. Epub 2016 Feb 13. PMID: 26872471

Article Published Date : Feb 12, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Glioblastoma

Pharmacological Actions : Anti-Angiogenic, Antiproliferative , Cell cycle arrest

Additional Keywords : Natural Substance/Drug Synergy

[+]

AGE showed synergistic effects with NTX on inhibition of tumor growth and increment of survival times.Jun 30, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacognosy Res. 2013 Jul ;5(3):189-94. PMID: 23901215

Article Published Date : Jun 30, 2013

Study Type : Animal Study

Additional Links

Substances : Garlic: Aged

Diseases : Fibrosarcoma

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Antiproliferative , Chemopreventive

Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts

[+]

Alleviation of fructose-induced Alzheimer's disease in rats by pioglitazone and decaffeinated green coffee bean extract.Apr 30, 2021

Click here to read the entire abstract

Pubmed Data : J Food Biochem. 2021 May ;45(5):e13715. Epub 2021 Mar 29. PMID: 33782984

Article Published Date : Apr 30, 2021

Study Type : Animal Study

Additional Links

Substances : Green Coffee Bean

Diseases : Alzheimer's Disease, High Fructose Diet

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Alpha-tocopherol attenuates the anti-tumor activity of crizotinib against cells transformed by NPM-ALK.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2017 ;12(8):e0183003. Epub 2017 Aug 14. PMID: 28806414

Article Published Date : Dec 31, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Vitamin E: alpha tocopherol

Pharmacological Actions : Antineoplastic Agents, Apoptotic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Ameliorative effect of Metformin / alpha-lipoic acid combination on diabetic nephropathy.Jun 29, 2024

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2024 Jun 30 ;135:112294. Epub 2024 May 21. PMID: 38776856

Article Published Date : Jun 29, 2024

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Diabetic Nephropathy

Pharmacological Actions : Cardioprotective, Renoprotective

Additional Keywords : Natural Substance/Drug Synergy

[+]

An extract of Allspice was shown to be effective in decreasing the growth of MB231 tumors by oral administration, and this effect was greater when pretreated with AAE as a chemo-preventive agent.Apr 13, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2015 Apr 14. Epub 2015 Apr 14. PMID: 25945840

Article Published Date : Apr 13, 2015

Study Type : Animal Study

Additional Links

Substances : Allspice

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : AKT-mammalian target of rapamycin (mTOR) pathway inhibitor, Apoptotic, Autophagy Up-regulation, Chemopreventive

Additional Keywords : Dietary Concentrations, Drug: Rapamycin, Natural Substance/Drug Synergy

[+]

Anthocyanins work in synergy with trastuzumab by induced apoptosis, inhibited cell growth and affected HER2 downstream signaling.Sep 30, 2014

Click here to read the entire abstract

Pubmed Data : Mol Med Rep. 2014 Oct ;10(4):1921-6. Epub 2014 Jul 22. PMID: 25070704

Article Published Date : Sep 30, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Anthocyanins, Cyanidin 3-glucoside

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Anti-Tumor, Antiproliferative , apoptosis

Additional Keywords : Drug: Trastuzumab, Natural Substance/Drug Synergy, Supplements

[+]

Anti-tumor activity of tanshinone IIA in combined with cyclophosphamide against Lewis mice with lung cancer.Jan 10, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Trop Med. 2016 11 ;9(11):1084-1088. Epub 2016 Oct 22. PMID: 27890369

Article Published Date : Jan 10, 2016

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Lung Cancer

Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Anticancer effects of combination of indole-3-carbinol and hydroxychloroquine on ehrlich ascites carcinoma.Aug 10, 2021

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2021 Aug 11:1-17. Epub 2021 Aug 11. PMID: 34379013

Article Published Date : Aug 10, 2021

Study Type : Animal Study

Additional Links

Substances : Indole-3-Carbinol

Diseases : Ehrlich carcinoma

Pharmacological Actions : Apoptotic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Antinociceptive synergy between metamizole and hesperidin. Jan 18, 2021

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Pubmed Data : Arch Med Res. 2021 Jan 19. Epub 2021 Jan 19. PMID: 33483148

Article Published Date : Jan 18, 2021

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Chronic Pain

Pharmacological Actions : Antinoceceptive

Additional Keywords : Natural Substance/Drug Synergy

[+]

Antitumor effect of epigallocatechin gallate and vincristine in mice with L5178Y lymphoma.Nov 01, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Plants (Basel). 2023 Nov 2 ;12(21). Epub 2023 Nov 2. PMID: 37960113

Article Published Date : Nov 01, 2023

Study Type : Animal Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Lymphoma

Pharmacological Actions : Bcl-2 protein down-regulation, Chemopreventive, Chemosensitizer

Additional Keywords : Natural Substance/Drug Synergy

[+]

Ascorbic acid protects against the nephrotoxicity and apoptosis caused by colistin and affects its pharmacokinetics.Jan 31, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Antimicrob Chemother. 2012 Feb ;67(2):452-9. Epub 2011 Nov 28. PMID: 22127588

Article Published Date : Jan 31, 2012

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Renoprotective

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Antibiotics

[+]

Aspalathin from rooibos improves the hypoglycemic potential of metformin in type 2 diabetic mice.Nov 13, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Physiol Res. 2018 Nov 14 ;67(5):813-818. Epub 2018 Jul 25. PMID: 30044119

Article Published Date : Nov 13, 2018

Study Type : Animal Study

Additional Links

Substances : Rooibos

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Hypoglycemic Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Baicalein enhances the effect of acarbose on the improvement of nonalcoholic fatty liver disease associated with prediabetes.Aug 31, 2021

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2021 Sep 1 ;69(34):9822-9836. Epub 2021 Aug 18. PMID: 34406004

Article Published Date : Aug 31, 2021

Study Type : Animal Study

Additional Links

Substances : Baicalein

Diseases : Nonalcoholic fatty liver disease (NAFLD), Prediabetes

Pharmacological Actions : Hepatoprotective

Additional Keywords : Natural Substance/Drug Synergy

[+]

Berberine might be a promising synergist to enhance the antimicrobial activity of azithromycin in vitro and in vivo.Jul 23, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell Physiol Biochem. 2017 Jul 24 ;42(4):1657-1669. Epub 2017 Jul 24. PMID: 28738346

Article Published Date : Jul 23, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : Pseudomonas aeruginosa

Pharmacological Actions : Antimicrobial

Additional Keywords : Natural Substance/Drug Synergy

[+]

Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells.Apr 18, 2004

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Br J Cancer. 2004 Apr 19 ;90(8):1672-8. PMID: 15083202

Article Published Date : Apr 18, 2004

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Betulinic acid

Diseases : Cancer Metastasis, Melanoma, Skin Cancer

Pharmacological Actions : Anti-metastatic, Chemosensitizer

Additional Keywords : Natural Substance/Drug Synergy

[+]

Binding of berberine to PEBP1 synergizes with sorafenib to induce the ferroptosis of hepatic stellate cells.Oct 08, 2023

Click here to read the entire abstract

Pubmed Data : Amino Acids. 2023 Oct 9. Epub 2023 Oct 9. PMID: 37814030

Article Published Date : Oct 08, 2023

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective

Additional Keywords : Natural Substance/Drug Synergy

[+]

Brazil nut (Bertholletia excelsa) and metformin abrogate cardiac complication in fructose/STZ-induced type 2 diabetic rats.Dec 31, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Food Nutr Res. 2024 ;68. Epub 2024 Aug 20. PMID: 39239455

Article Published Date : Dec 31, 2023

Study Type : Animal Study

Additional Links

Diseases : Diabetes: Oxidative Stress, Diabetes Mellitus: Type 2

Pharmacological Actions : Antioxidants

Additional Keywords : Natural Substance/Drug Synergy

[+]

Calcitriol enhanced the efficacy of irinotecan in growth inhibition and apoptosis induction.Jul 24, 2016

Click here to read the entire abstract

Pubmed Data : Mol Cancer Ther. 2016 Jul 25. Epub 2016 Jul 25. PMID: 27458137

Article Published Date : Jul 24, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Vitamin D

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Cannabidiol enhances the antinociceptive effects of morphine and attenuates opioid-induced tolerance in the chronic constriction injury model.Oct 27, 2022

Click here to read the entire abstract

Pubmed Data : Behav Brain Res. 2022 Oct 28 ;435:114076. Epub 2022 Aug 24. PMID: 36028000

Article Published Date : Oct 27, 2022

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Morphine Tolerance/Dependence

Pharmacological Actions : Analgesics

Additional Keywords : Natural Substance/Drug Synergy

[+]

Chrysanthemum indicum could enhance the anti-cancer activity of bleomycin and reduce the its induced pulmonary injury in H22 tumor-bearing mice.Feb 23, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2017 Feb 24 ;18(3). Epub 2017 Feb 24. PMID: 28245556

Article Published Date : Feb 23, 2017

Study Type : Animal Study

Additional Links

Substances : Chrysanthemum Indicum

Diseases : Chemotherapy-Induced Toxicity: Bleomycin

Pharmacological Actions : Chemoprotective Agents, Chemosensitizer

Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts

[+]

Chrysin strengthened the therapeutic efficacy of docetaxel and diminished the adverse effect of it.May 04, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Integr Cancer Ther. 2016 May 5. Epub 2016 May 5. PMID: 27151585

Article Published Date : May 04, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Chrysin

Diseases : Carcinoma: Non-Small-Cell Lung, Chemotherapy and Radiation Toxicity, Gastric Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemoprotective Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Cinnamaldehyde enhances antimelanoma activity through covalently binding ENO1 and exhibits a promoting effect with dacarbazine.Jan 28, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancers (Basel). 2020 Jan 29 ;12(2). Epub 2020 Jan 29. PMID: 32013122

Article Published Date : Jan 28, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cinnamaldehyde

Diseases : Melanoma

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Co-administration of carrot fruit significantly enhanced both ulcer preventive effects and ulcer healing properties of the pantoprazole.Nov 12, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2020 Nov 13 ;25(22). Epub 2020 Nov 13. PMID: 33202703

Article Published Date : Nov 12, 2020

Study Type : Animal Study

Additional Links

Substances : Carrot

Diseases : Gastric Ulcer

Pharmacological Actions : Anti-Ulcer Agents, Gastroprotective

Additional Keywords : Natural Substance/Drug Synergy

[+]

Co-administration of chloroquine and coenzyme Q 10 improved treatment outcome during experimental cerebral malaria.May 31, 2022

Click here to read the entire abstract

Pubmed Data : J Parasit Dis. 2022 Jun ;46(2):466-475. Epub 2022 Jan 31. PMID: 35692470

Article Published Date : May 31, 2022

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10

Diseases : Malaria

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Co-administration of EGb 761 and donepezil exerted better anti-amnestic effect.Dec 24, 2020

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2020 Dec 25 ;269:113711. Epub 2020 Dec 25. PMID: 33352242

Article Published Date : Dec 24, 2020

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Co-administration of hyperforin and lanicemine induces long-lasting antidepressant effects.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Mol Neurosci. 2018 ;11:456. Epub 2018 Dec 12. PMID: 30618608

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Hyperforin

Diseases : Depression

Pharmacological Actions : Antidepressive Agents, Brain-derived neurotrophic factor modulator

Additional Keywords : Natural Substance/Drug Synergy

[+]

Co-delivery of deferoxamine and hydroxysafflor yellow A to accelerate diabetic wound healing via enhanced angiogenesis.Oct 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Deliv. 2018 Nov ;25(1):1779-1789. PMID: 30338719

Article Published Date : Oct 31, 2018

Study Type : Animal Study

Additional Links

Substances : Safflower

Diseases : Wound Healing

Pharmacological Actions : Angiogenesis Inducing Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Combination effects of metformin and a mixture of lemon balm and dandelion on high-fat diet-induced metabolic alterations.Mar 17, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antioxidants (Basel). 2022 Mar 18 ;11(3). Epub 2022 Mar 18. PMID: 35326230

Article Published Date : Mar 17, 2022

Study Type : Animal Study

Additional Links

Substances : Dandelion , Lemon Balm

Diseases : High Fat Diet, Insulin Resistance, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective

Additional Keywords : Natural Substance/Drug Synergy

[+]

Combination of berberine with pentoxifylline illustrated a synergistic effect in attenuation of diclofenac-induced acute kidney injury.Mar 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Crit Illn Inj Sci. 2019 Apr-Jun;9(2):69-74. PMID: 31334048

Article Published Date : Mar 31, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Kidney Damage: Drug-Induced

Pharmacological Actions : Renoprotective

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Diclofenac

[+]

Combination of curcumin and mitomycin C can synergistically inhibit tumor growth in MCF-7 breast cancer xenografts and induce apoptosis in breast cancer MCF-7 cells.Dec 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2014 ;15(9):16284-301. Epub 2014 Sep 15. PMID: 25226537

Article Published Date : Dec 31, 2013

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Breast Cancer

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemotherapeutic

Additional Keywords : Drug: Mitomycin, Natural Substance/Drug Synergy

[+]

Combination of erythromycin and curcumin alleviates Staphylococcus aureus induced osteomyelitis.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Cell Infect Microbiol. 2017 ;7:379. Epub 2017 Aug 24. PMID: 28884090

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Osteomyelitis, Staphylococcus aureus: Methicillin-resistant (MRSA)

Pharmacological Actions : Anti-Bacterial Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

Combination of Ocimum sanctum extract and Levetiracetam ameliorates cognitive dysfunction and hippocampal architecture in rat model of Alzheimer's disease.Dec 31, 2021

Click here to read the entire abstract

Pubmed Data : J Chem Neuroanat. 2022 03 ;120:102069. Epub 2021 Dec 29. PMID: 34973350

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Holy Basil

Diseases : Alzheimer's Disease, Neurodegenerative Diseases

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts

[+]

Combination of Panax notoginseng saponins and aspirin potentiates platelet inhibition with alleviated gastric injury.Dec 24, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2020 Dec 25 ;134:111165. Epub 2020 Dec 25. PMID: 33370633

Article Published Date : Dec 24, 2020

Study Type : Animal Study

Additional Links

Substances : Panax Notoginseng

Diseases : Aspirin-Induced Toxicity

Pharmacological Actions : Gastroprotective

Additional Keywords : Natural Substance/Drug Synergy

[+]

Combination of Rheum ribes and metformin against diabetes, thermal hyperalgesia, and tactile allodynia.Aug 31, 2018

Click here to read the entire abstract

Pubmed Data : Altern Ther Health Med. 2018 Sep ;24(5):33-43. PMID: 28987074

Article Published Date : Aug 31, 2018

Study Type : Animal Study

Additional Links

Substances : Rhubarb

Diseases : Allodynia, Hyperalgesia

Pharmacological Actions : Antinoceceptive , Antioxidants, Hypoglycemic Agents

Additional Keywords : Natural Substance/Drug Synergy, Phytotherapy, Plant Extracts

[+]

Combination therapy of carnosic acid and methotrexate effectively suppressed the inflammatory markers and oxidative stress in experimental arthritis.Oct 20, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2022 Oct 21 ;27(20). Epub 2022 Oct 21. PMID: 36296709

Article Published Date : Oct 20, 2022

Study Type : Animal Study

Additional Links

Substances : Carnosic Acid

Diseases : Inflammation, Oxidative Stress, Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

Additional Keywords : Natural Substance/Drug Synergy

[+]

Combinational treatment effect of tetrahydrocurcumin and celecoxib on cervical cancer cell-induced tumor growth and tumor angiogenesis.Jun 30, 2016

Click here to read the entire abstract

Pubmed Data : J Med Assoc Thai. 2016 Jul ;99 Suppl 4:S23-31. PMID: 29916670

Article Published Date : Jun 30, 2016

Study Type : Animal Study

Additional Links

Substances : Curcumin, Tetrahydrocurcumin

Diseases : Cervical Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Angiogenic, Apoptotic, Cyclooxygenase 2 Inhibitors

Additional Keywords : Natural Substance/Drug Synergy

[+]

Combinations of nobiletin with paclitaxel and carboplatin significantly suppressed the growth of subcutaneous A549 tumors xenografts in nude mice.Mar 31, 2014

Click here to read the entire abstract

Pubmed Data : Planta Med. 2014 Apr ;80(6):452-7. Epub 2014 Mar 31. PMID: 24687742

Article Published Date : Mar 31, 2014

Study Type : Animal Study

Additional Links

Substances : Nobiletin

Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Drug: Carboplatin, Natural Substance/Drug Synergy, Plant Extracts

[+]

Combined treatment of curcumin with low doses of prednisolone may find therapeutic use in arthritis.Dec 31, 2013

Click here to read the entire abstract

Pubmed Data : J Pharm Pharmacol. 2014 Jan ;66(1):133-44. Epub 2013 Oct 21. PMID: 24138213

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts

[+]

Combing sinomenine and gabapentin or ligustrazine hydrochloride could be highly beneficial in neuropathic pain therapies.Jul 04, 2019

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2019 Jul 5 ;854:101-108. Epub 2019 Apr 4. PMID: 30954565

Article Published Date : Jul 04, 2019

Study Type : Animal Study

Additional Links

Substances : Sinomenine

Diseases : Neuropathic Pain, Sciatica, Spinal Cord Injuries

Pharmacological Actions : Analgesics

Additional Keywords : Natural Substance/Drug Synergy

[+]

Corn silk polysaccharides have potent inhibitory effects on implanted H22 tumors.Sep 30, 2014

Click here to read the entire abstract

Pubmed Data : Zhong Yao Cai. 2014 Oct ;37(10):1833-6. PMID: 25895394

Article Published Date : Sep 30, 2014

Study Type : Animal Study

Additional Links

Substances : Corn Silk

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Liver Cancer

Pharmacological Actions : Chemoprotective Agents

Additional Keywords : Chemotherapeutic Agent: Cyclophosphamide, Natural Substance/Drug Synergy, Polysaccharides

[+]

Curcumin combined with metformin may act synergistically on dyslipidemia and oxidative stress, as well as increased PON 1 levels.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Diabetol Metab Syndr. 2019 ;11:33. Epub 2019 Apr 30. PMID: 31061679

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Dyslipidemias, Hyperglycemia

Pharmacological Actions : Antioxidants, Hypoglycemic Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Curcumin enhances the activity of fluconazole against Cryptococcus gattii-induced cryptococcosis infection in mice.Oct 06, 2015

Click here to read the entire abstract

Pubmed Data : J Appl Microbiol. 2015 Oct 7. Epub 2015 Oct 7. PMID: 26442997

Article Published Date : Oct 06, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cryptococcosis

Pharmacological Actions : Antifungal Agents

Additional Keywords : Drug: Fluconazole, Natural Substance/Drug Synergy

[+]

Curcumin sensitizes human colorectal cancer to capecitabine.Oct 31, 2009

Click here to read the entire abstract

Pubmed Data : Int J Cancer. 2009 Nov 1 ;125(9):2187-97. PMID: 19623659

Article Published Date : Oct 31, 2009

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

Dandelion and lemongrass extracts were able to significantly reduce the tumour burden in prostate cancer xenograft models.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:2951428. Epub 2019 Jul 17. PMID: 31391857

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Dandelion , Lemongrass

Diseases : Prostate Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Natural Substance/Drug Synergy, Selective Cytotoxicity

[+]

Distinct interactions of cannabidiol and morphine in three nociceptive behavioral models in mice.Mar 31, 2015

Click here to read the entire abstract

Pubmed Data : Behav Pharmacol. 2015 Apr ;26(3):304-14. PMID: 25485642

Article Published Date : Mar 31, 2015

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Additional Keywords : Natural Substance/Drug Synergy

[+]

Effects of azithromycin and Chlorella vulgaris treatment on certain cytokine values and NK cell activity in an acute murine toxoplasmosis model.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Mikrobiyol Bul. 2017 Jan ;51(1):52-61. PMID: 28283010

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Chlorella (Algae)

Diseases : Toxoplasma gondii Infection, Toxoplasmosis

Pharmacological Actions : Antiparasitic Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Effects of probiotics on pentylenetetrazol-induced convulsions.Jan 09, 2021

Click here to read the entire abstract

Pubmed Data : Epilepsy Res. 2021 10 ;176:106723. Epub 2021 Jul 12. PMID: 34304017

Article Published Date : Jan 09, 2021

Study Type : Animal Study

Additional Links

Substances : Probiotics

Diseases : Seizures

Pharmacological Actions : Anticonvulsants, Gastrointestinal Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Ellagic acid enhances morphine analgesia and attenuates the development of morphine tolerance and dependence.Oct 14, 2014

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2014 Oct 15 ;741:272-80. Epub 2014 Aug 30. PMID: 25179576

Article Published Date : Oct 14, 2014

Study Type : Animal Study

Additional Links

Substances : Ellagic Acid

Diseases : Morphine Tolerance/Dependence

Additional Keywords : Natural Substance/Drug Synergy

[+]

Embelin protects against acute pentylenetetrazole-induced seizures and positively modulates cognitive function.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2019 ;10:1249. Epub 2019 Oct 25. PMID: 31708779

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : False Black Pepper

Diseases : Seizures: Drug-Induced

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Endostar combined with ginsenoside Rg3 has stronger inhibiting effect on breast cancer tumor growth in tumor-bearing mice than single drug.Jan 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Trop Med. 2016 Feb ;9(2):180-3. Epub 2016 Jan 11. PMID: 26919952

Article Published Date : Jan 31, 2016

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Breast Cancer

Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor A Inhibitor, Vascular Endothelial Growth Factor C Inhibitor, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Natural Substance/Drug Synergy

[+]

Evening primrose oil significantly reduced the synovial hyperplasia and inflammatory cells invasion in joint tissues.Sep 30, 2014

Click here to read the entire abstract

Pubmed Data : Inflammopharmacology. 2014 Oct ;22(5):305-17. Epub 2014 Mar 25. PMID: 24664592

Article Published Date : Sep 30, 2014

Study Type : Animal Study

Additional Links

Substances : Evening Primrose Oil

Diseases : Arthritis, Inflammation, Lipid Peroxidation, Oxidative Stress, Rheumatoid Arthritis

Pharmacological Actions : Anti-Angiogenic, Anti-Inflammatory Agents, Antioxidants, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine.Apr 14, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Clin Cancer Res. 2012 Apr 15 ;18(8):2220-9. Epub 2012 Feb 20. PMID: 22351692

Article Published Date : Apr 14, 2012

Study Type : Animal Study

Additional Links

Substances : Tocotrienol: Gamma, Vitamin E

Diseases : Gastric Cancer

Pharmacological Actions : Anti-metastatic, Bcl-2 protein down-regulation, Chemosensitizer, Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

Flos Lonicera and metformin in combination exerts a synergistic effect on the improvement of hepatosteatosis and insulin sensitivity.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Microbiol. 2017 ;8:2271. Epub 2017 Nov 17. PMID: 29204141

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Honeysuckle

Diseases : Diabetes Mellitus: Type 2, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Gastrointestinal Agents, Hepatoprotective, Hypoglycemic Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Fluoxetine and wheatgrass combination demonstrated a more significant neuroprotective impact in treating Alzheimer's disease.Nov 07, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2021 Nov 8 ;26(21). Epub 2021 Nov 8. PMID: 34771159

Article Published Date : Nov 07, 2021

Study Type : Animal Study

Additional Links

Substances : Wheat Grass

Diseases : Alzheimer's Disease

Pharmacological Actions : Hepatoprotective, Neuroprotective Agents, Renoprotective

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Fluoxetine (trade name Prozac)

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View the Evidence: 704 Abstracts with Natural Substance/Drug Synergy Research

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Ginkgo biloba preparations plus donepezil can improve clinical effectiveness rate and vocabulary memory outcomes.Dec 31, 2022

Ginseng-containing traditional medicine preparations in combination with fluoropyrimidine-based chemotherapy for advanced gastric cancer.Dec 31, 2022

A review of the beneficial effects of antioxidants on Helicobacter pylori eradication.Nov 30, 2018

Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis.Dec 31, 2018

Honeysuckle combined with conventional therapy may be beneficial for the treatment of COVID-19 in improving lung CT, clinical cure rate, clinical symptoms.Dec 31, 2020

Specific combinations of traditional medicines appeared to produce higher contributions to tumor response rate than the TMs individually.Aug 05, 2015

The addition of probiotics to standard therapy is associated with improved H. pylori eradication rates in both children and adults.Dec 31, 2015

Bee products are effective in symptomatic treatment of upper respiratory tract infections.Dec 31, 2019

Probiotic Bifidobacterium longum supplied with methimazole improved the thyroid function of Graves' disease patients through the gut-thyroid axis Jan 06, 2021

"Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer."Feb 28, 2011

Adding 100 g of almonds daily to chronic statin therapy for 4 weeks significantly reduced non-HDL-C.Dec 31, 2014

Adding Berberis vulgaris fruit extract on metronidazole improve the efficacy of bacterial vaginosis therapy.Jul 31, 2016

Adding M. communis extract to metronidazole increases the efficiency of bacterial vaginosis treatment.Feb 28, 2017

Addition of epigallocatechin gallate 400 mg to sofosbuvir 400 mg + daclatisvir 60 mg in in treatment of patients with chronic hepatitis C.Jan 18, 2019

Adjuvant palmitoylethanolamide therapy with risperidone improves negative symptoms in patients with schizophrenia.Sep 30, 2022

Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection.Nov 20, 2012

Antimicrobial activity of Prunella Vulgaris extracts against multi-drug resistant Escherichia Coli from patients of urinary tract infection.Apr 30, 2018

Application of Peganum harmala seed can be useful in reducing urinary symptoms in patients with benign prostatic hyperplasia.Dec 31, 2016

Black cumin seeds decreased Methotrexate hepatotoxicity and improved survival in children with ALLMar 19, 2015

Cannabis users report greater pain relief in combination with opioids than when opioids are used alone.Jan 31, 2015

Clinical efficacy of acetylcysteine combined with tetrandrine tablets on patients with silicosis.Jul 31, 2020

Curcumin could reverse the development of depression and enhance the outcome of antidepressants treatment in major depressive disorder.Jul 31, 2015

Curcumin may be a safe and effective therapy for maintenance of remission in quiescent UC when given as adjunctive therapy along with mesalamine or sulfasalazine. Dec 31, 2011

Curcuminoids with piperine may be used as a safe and effective add on to standard antidepressants in patients with major depressive disorders.Dec 31, 2014

Effective analgesic between acetominophen + B vitamins vs. acetominophen in pediatric ambulatory surgery.Dec 31, 2009

Efficacy and tolerance of cannabidiol in the treatment of epilepsy in patients with Rett syndrome.Jul 23, 2023

Fecal microbiota transplantation plus tislelizumab and fruquintinib in refractory microsatellite stable metastatic colorectal cancer.Nov 30, 2023

Helicobacter pylori eradication: Sequential therapy and Lactobacillus reuteri supplementation.Nov 20, 2012

L-Theanine adjunct to risperidone in the treatment of chronic schizophrenia inpatients.Nov 30, 2023

Lavandula angustifilia infusion has some positive therapeutic effects on depressed patients most importantly decreases mean depression score and might be used alone or as an adjunct to other anti-depressant drugs.Jul 31, 2013

Milled flaxseed lowers total and LDL cholesterol in patients with peripheral artery disease.Mar 31, 2015

N-acetylcysteine combined with dexamethasone treatment improves sudden sensorineural hearing loss.Dec 31, 2020

Novel bioenhanced curcumin with mesalamine for induction of clinical and endoscopic remission in mild-to-moderate ulcerative colitis.Aug 31, 2021

Palmitoylethanolamide and acetyl-L-carnitine act synergistically with duloxetine and pregabalin in fibromyalgia.May 31, 2023

Preparation and optimization of garlic oil/apple vider vinegar nanoemulsion loaded with minoxidil to treat alopecia.Dec 13, 2021

Prunella vulgaris may be a potential adjuvant medicine for breast cancer treatment.Dec 31, 2017

Resveratrol adjunct to methylphenidate improves symptoms of attention-deficit/hyperactivity disorder.Apr 30, 2021

Silibinin may improve the effects of methotrexate on certain biochemical and clinical markers of patients with active rheumatoid arthritis.Jun 30, 2016

Somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide led to an overall clinical benefit been achieved in 75% of cases.Dec 31, 2012

Synergism of allicin in combination with itraconazole and terbinafine, which could be a reference for the treatment of tinea capitis due to M. canis.Dec 31, 2020

The addition of POMx to simvastatin therapy in hypercholesterolemic patients improved oxidative stress and lipid status in the patient's serum and in their HMDM. Dec 31, 2013

The administration of soybean could enhance the response to SSRI anti depressants in menopausal women.Feb 28, 2014

The administration of soybean could enhance the response to SSRI anti depressants in menopausal women.Feb 28, 2014

The combination of bevacizumab and tocotrienol is potent in chemotherapy refractory ovarian cancer. Feb 28, 2019

The combination of serenoa repens, selenium, lycopene and bromelain are beneficial in patients with chronic bacterial prostatitis.Oct 04, 2016

The combined use of echinacea with azithromycin produced favourable outcome than azithromycin alone in pediatric patients with recurrent tonsillitis.Jul 31, 2020

The effect of coenzyme Q10 plus trimetazidine on acute viral myocarditis treatment.Dec 31, 2020

The efficacy of curcuminoids in improvement of ulcerative colitis symptoms and patients' self-reported well-being.Oct 31, 2018

The potential prebiotic berberine combined with methimazole improved the therapeutic effect of Graves' disease patients.Dec 31, 2020

Therapeutic effect of curcumin in women with polycystic ovary syndrome receiving metformin.Dec 31, 2020

Vitamin D supplementation improves the therapeutic effect of mometasone on allergic rhinitis.Sep 15, 2023

6-shogaol, 6-gingerol and pterostilbene selectively killed breast cancer stem cells.Mar 10, 2015

Amurensin G. was a potent SIRT1 Inhibitor which led to the down regulation of multidrug resistance.Oct 31, 2010

Combinations of EGCG and anticancer compounds induced synergistic anticancer effects in vitro and in vivo experiments, and showed an average reduction in tumor volume by 70.3 %.Aug 31, 2015

Findings suggest that Plantago ovata husk could be a potentially useful adjuvant in chemotherapy for colorectal cancer.Jun 01, 2012

Hydrocortisone and ascorbic acid synergistically prevent and repair lipopolysaccharide-induced pulmonary endothelial barrier dysfunction.Jan 10, 2017

Piperine enhanced mitomycin-C therapy in human cervical cancer cells.Nov 19, 2017

Prunella vulgaris has potent anti-Ebola virus activity and may be developed as a novel antiviral approach against EBOV infection.Feb 29, 2016

Pterostilbene might be used to modulate two anticancer compounds in well-defined sets of GBM patients.Nov 07, 2016

The combination of centchroman with genistein has selective cytotoxic effect for human breast cancer cell lines.Oct 31, 2016

These results suggest deguelin could have potential for the treatment of human CLL.Dec 31, 2015

Ursolic acid enhances the sensitivity of MCF-7 and MDA-MB-231 cells to epirubicin.May 24, 2022

Baicalin acts as an adjuvant to potentiate the activity of azithromycin against Staphylococcus saprophyticus biofilm: an in vitro, in vivo, and molecular study.Oct 11, 2022

Beetroot-carrot juice can be used as an effective treatment for CLL alone or in combination with chlorambucil.Jun 14, 2015

Dihydrotanshinone I is effective against drug-resistant Helicobacter pylori.Feb 16, 2021

Eugenol works synergistically with colistin against colistin-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae.Sep 13, 2023

Fucoidan enhances the chemotherapeutic sensitivity of capecitabine in colon cancer Sep 24, 2022

In vitro and in vivo synergistic effect of chrysin in combination with colistin against Acinetobacter baumannii.Dec 31, 2021

Naringenin restores colistin activation against colistin-resistant gram-negative bacteria in vitro and in vivo.Dec 31, 2021

Omalizumab ensures compatibility to bee venom immunotherapy (VIT) after VIT-induced anaphylaxis in a patient with systemic mastocytosis.Dec 31, 2020

Oxidative lipid damage by naringenin selectively sensitizes chronic myeloid leukemia cell lines.Sep 02, 2024

Synergistic effect of oridonin and a PI3K/mTOR inhibitor on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma.Jan 22, 2016

Natural Substance/Drug Synergy

View the Evidence:
704 Abstracts with Natural Substance/Drug Synergy Research