Natural Substance/Drug Synergy

Name	AC	CK
Antibiotics	8	28
Fluoxetine (trade name Prozac)	4	24
Methotrexate	1	20
Sertraline	2	20
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	2	11
Acetaminophen	1	10
Antidepressants	1	10
Mesalamine	1	10
Paracetamol	1	10
Simvastatin	1	10
Statin Drugs	1	10
Doxorubicin	2	7
Cisplatin	2	4
Diclofenac	2	4
Indomethacin	2	3
Cadmium	1	2
Fluorouracil (5-FU or f5U)	1	2
Glibenclamide	1	2
Nicotine	1	2
Oseltamivir (trade name Tamiflu)	1	2
Paclitaxel	1	2
Paraquat	1	2
Prednisolone	1	2
Zoledronic Acid	1	2
Aspirin	1	1
Atorvastatin	1	1
Dexamethasone	1	1
Herceptin	1	1

Name	AC	CK
Breast Cancer	67	109
Helicobacter Pylori Infection	17	76
Depression	10	68
Colorectal Cancer	21	58
Alzheimer's Disease	10	44
Staphylococcus aureus infection	39	41
Rheumatoid Arthritis	8	40
Cancers: All	31	36
Liver Cancer	27	34
Escherichia coli Infections	24	33
Gastric Cancer	9	32
Candida Albicans	29	31
Chronic Pain	8	31
Ulcerative Colitis	4	31
Breast Cancer: Triple Negative	21	30
Lung Cancer	23	30
Oxidative Stress	13	30
Schizophrenia	3	30
Cancers: Drug Resistant	22	29
Staphylococcus aureus: Methicillin-resistant (MRSA)	26	29
Pseudomonas aeruginosa	24	27
Colon Cancer	19	26
Infection: Antibiotic Resistant	15	24
Coronavirus Infection	4	23
Ovarian Cancer	7	22
Bacterial Vaginosis	2	20
Depression: Postmenopausal	2	20
Diarrhea: Antibiotic-Associated	1	20
Graves Disease	2	20
High Cholesterol	2	20
Inflammation	13	20
Polycystic Ovary Syndrome	2	20
Melanoma	12	16
Epilepsy	4	15
Klebsiella Infections	12	15
Multiple Myeloma	12	15
Chemotherapy-Induced Toxicity: Cyclophosphamide	3	14
Diabetes Mellitus: Type 2	7	14
Glioblastoma	12	14
Neuropathic Pain	7	14
Atherosclerosis	3	13
Carcinoma: Non-Small-Cell Lung	10	13
Acute lymphoblastic leukemia (ALL)	3	12
Cervical Cancer	7	12
Hepatitis C	3	12
Prostate Cancer	10	12
Acinetobacter baumannii infection	9	11
Candida Infection	11	11
Allergic Rhinitis	1	10
Alopecia	1	10
Anxiety Disorders	1	10
Attention Deficit Disorder with Hyperactivity	1	10
Breast Cancer: Metastatic	1	10
C-Reactive Protein	1	10
Cholesterol: High	1	10
Colorectal Adenomas	1	10
Depressive Disorder	1	10
Diabetic Nephropathy	5	10
Drug-Induced Toxicity: Methotrexate	1	10
Fibromyalgia	1	10
Hearing Loss: Sudden	1	10
Leukemia	10	10
Myocarditis: Viral	1	10
Peripheral Arterial Disease	1	10
Prostatic Hyperplasia	1	10
Prostatitis: Bacterial	1	10
Rett Syndrome	1	10
Salmonella Infections	8	10
Silicosis	1	10
Tinea	1	10
Tonsillitis	1	10
Triglycerides: Elevated	1	10
Upper Respiratory Infections	1	10
Urinary Tract Infections	1	10
Arthritis	5	9
Skin Cancer	6	9
Glioma	6	8
Mycobacterium Tuberculosis	8	8
Sepsis	3	8
Chronic Lymphocytic Leukemia	3	7
Gram-Negative Bacterial Infections	5	7
Hyperalgesia	4	7
Hyperglycemia	4	7
Leishmaniasis	4	7
Lipopolysaccharide-Induced Toxicity	2	7
Osteosarcoma	7	7
Pancreatic Cancer	6	7
Allodynia	3	6
Breast Cancer Stem Cells	2	6
Breast Cancer: Drug Resistant	2	6
Esophageal Cancer	4	6
Glioblastoma Multiforme	2	6
Nonalcoholic fatty liver disease (NAFLD)	3	6
Seizures	3	6
Spinal Cord Injuries	3	6
Toxoplasma gondii Infection	3	6
Acute Myeloid Leukemia	5	5
Cognitive Decline/Dysfunction	3	5
Ebola Virus Infections	1	5
Endothelial Dysfunction	1	5
Kidney Cancer	5	5
Lymphoma: B-Cell	3	5
Morphine Tolerance/Dependence	3	5
Mycobacterium abscessus	3	5
Wound Healing	4	5
Candidiasis	3	4
Diabetic Complications	2	4
Gram-Positive Bacterial Infections	4	4
HIV Infections	4	4
High Fat Diet	2	4
Hyperlipidemia	2	4
Lipid Peroxidation	2	4
Liver Fibrosis	2	4
Malaria	3	4
Malignant Melanoma	2	4
Obesity	2	4
Promyelocytic leukemia	4	4
Seizures: Drug-Induced	2	4
Staphylococcal Infections	2	4
Toxoplasmosis	2	4
Bacillus subtilis infections	3	3
Bacterial Infections	3	3
Cachexia: Cancer	2	3
Campylobacter Infections	3	3
Cancer Metastasis	2	3
Cancers: Multi-Drug Resistant	3	3
Candida Glabrata	3	3
Chemotherapy-Induced Toxicity	2	3
Chemotherapy-Induced Toxicity: Bleomycin	2	3
Chemotherapy-Induced Toxicity: Cisplatin	2	3
Chronic Myeloid Leukemia	1	3
Cryptococcosis	2	3
Enterococcus Infections	3	3
Hepatitis B	2	3
Influenza A	2	3
Leukemia: Chronic Lymphocytic Leukemia (CLL)	1	3
Leukemia: Chronic myelogenous leukemia (CML)	3	3
Lymphoma	2	3
Mastocytosis	1	3
Schistosomiasis	2	3
Staphylococcus epidermidis	3	3
Steptococcus Mutans Infections	3	3
Trypanosomiasis	2	3
Acute T cell Leukemias	2	2
Anxiety	1	2
Aspirin-Induced Toxicity	1	2
Autism Spectrum Disorders	1	2
Bladder Cancer	2	2
Brain Ischemia	1	2
Burkitt Lymphoma	2	2
Candidiasis: Vulvovaginal	1	2
Cardiotoxicity: Chemotherapy-Induced	1	2
Chagas Disease	1	2
Chemically-Induced Liver Damage	1	2
Chemotherapy	2	2
Chemotherapy and Radiation Toxicity	1	2
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	2
Choriocarcinoma	2	2
Colitis	1	2
Dementia	2	2
Diabetes: Oxidative Stress	1	2
Drug-Induced Toxicity: Indomethacin	1	2
Dyslipidemias	1	2
Ehrlich carcinoma	1	2
Fatty Liver	1	2
Fibrosarcoma	1	2
Fungus Diseases	2	2
Gastric Ulcer	1	2
High Fructose Diet	1	2
Inflammatory Bowel Diseases	1	2
Influenza	1	2
Insulin Resistance	1	2
Kidney Damage: Chemically-Induced	1	2
Kidney Damage: Drug-Induced	1	2
Klesiella Pneumonia Infection	1	2
Laryngeal Cancer	2	2
Leukemia: Acute myelogenous leukemia (AML)	2	2
Liver Damage: Drug-Induced	1	2
Liver Metastasis From Colon Cancer	1	2
Memory Loss	1	2
Metabolic Diseases	1	2
Neurodegenerative Diseases	1	2
Osteoarthritis	1	2
Osteomyelitis	1	2
Osteoporosis	1	2
Parasitic Diseases	1	2
Prediabetes	1	2
Respiratory Infections	1	2
Sciatica	1	2
Sleep Disorders	1	2
Squamous cell carcinoma	2	2
Streptococcus Infections	2	2
Traumatic Brain Injury	1	2
Trichinosis	1	2
Tuberculosis Drug Induced Toxicity	1	2
AIDS	1	1
Animal Cancers	1	1
Aspergillosis	1	1
Asthma	1	1
Autoimmune Diseases	1	1
Bacillus Cereus infection	1	1
Bacterial Infections: Resistance/Biofilm Formation	1	1
Bone Cancer	1	1
Brain Cancer	1	1
Brain Inflammation	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Cancer: Pain	1	1
Cancers: Canine	1	1
Carcinosarcomas	1	1
Cardiovascular Disease	1	1
Chemotherapy-Induced Toxicity: Doxorubicin	1	1
Chemotherapy-Induced Toxicity: Tamoxifen	1	1
Cholangiocarcinoma	1	1
Coronavirus Disease (Covid-19)	1	1
Cystic Fibrosis	1	1
Cytomegalovirus Infections	1	1
Diabesity	1	1
Enterobacteriaceae Infections	1	1
Epileptic Seizures	1	1
Fungal Infection	1	1
Fungal Infections: Biofilm Formation/Resistance	1	1
Head and Neck Cancer	1	1
Headache	1	1
Hepatic Steatosis	1	1
Herpes Simplex Virus Type 1	1	1
Herpes Simplex Virus Type 2	1	1
Hypoglycemia	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Lipomucopolysaccharidosis	1	1
Listeria Infections	1	1
Lyme Borreliosis	1	1
Lyme Disease	1	1
Mastitis	1	1
Measles	1	1
Medulloblastoma	1	1
Melanoma: Metastatic	1	1
Memory Disorders	1	1
Multiple Sclerosis	1	1
Mycobacterium Infections	1	1
Nephritis	1	1
Neurofibromatosis	1	1
Non-Hodgkin's lymphoma: B Cell	1	1
Oral Cancer	1	1
Parkinson's Disease	1	1
Periodontal Diseases	1	1
Peripheral Neuropathies	1	1
Radiation Induced Illness	1	1
Retinoblastoma	1	1
Rhabdomyosarcoma	1	1
Schwannoma	1	1
Shigellosis	1	1
Sjogren's Syndrome	1	1
Spondylitis: Ankylosing	1	1
Streptococcus pyogenes	1	1
Tuberculosis: Drug Resistant	1	1

Name	AC	CK
Curcumin	48	136
NAC (N-acetyl-L-cysteine)	9	51
Vitamin C	32	46
Berberine	29	42
Citicoline	8	39
EGCG (Epigallocatechin gallate)	22	39
Vitamin D	15	37
Probiotics	5	34
Ginkgo biloba	5	26
Palmitoylethanolamide	5	26
Prunella vulgaris	3	25
Cannabidiol	12	24
Ginseng	3	24
Honeysuckle	2	22
Pomegranate	10	22
Chinese Skullcap	2	21
Resveratrol	11	21
Astragalus	1	20
Cranberry	1	20
Hedyotis corymbosa	1	20
Peony	1	20
Silibinin	10	20
Soy	2	20
Ginsenosides	14	19
Quercetin	16	19
Fucoidan	6	18
Melatonin	8	18
Nigella sativa (aka Black Seed)	4	16
Bee Propolis	5	15
Garlic	6	15
Allicin	5	14
Coenzyme Q10	3	14
Pterostilbene	6	14
Bee Venom	10	13
Cannabis	4	13
Royal Jelly	4	13
Thymoquinone	11	13
Lavender	3	12
Lycopene	2	12
Piperine	8	12
Theanine	2	12
Bromelain	2	11
Echinacea	2	11
Gingerol	5	11
Green Tea	5	11
Honey	2	11
Piperidines	2	11
Acetyl-l-carnitine	1	10
Almond	1	10
Apple Cider Vinegar	1	10
B-complex	1	10
Barberry	1	10
Bee Products	1	10
Bifidobacterium Longum	1	10
Curcuminoids	1	10
Flavonoids	7	10
Flaxseed	1	10
Lactobacillus reuteri	1	10
Mangiferin	8	10
Myrtle	1	10
Naringenin	5	10
Saw Palmetto	1	10
Selenium	1	10
Syrian rue	1	10
Tocotrienol: Delta	1	10
Wogonin	6	10
Parthenolide	8	9
Sulforaphane	8	9
Ursolic Acid	4	9
Carnosic Acid	5	8
Catechin	4	8
Chrysin	5	8
Honokiol	7	8
Oridonin	7	8
Polyphenols	8	8
Ginger	5	7
Luteolin	6	7
Tanshinone IIA	5	7
Anthocyanins	4	6
Baicalein	5	6
Beet	3	6
Genistein	2	6
Indole-3-Carbinol	5	6
Lactoferrin	5	6
Punicalagin	4	6
6-Shogaol	1	5
Amurensin G	1	5
Beta-Elemene	5	5
Betulinic acid	4	5
Carrot	2	5
Dandelion	3	5
Deguelin	1	5
Emodin	5	5
Eugenol	3	5
Nordihydroguaiaretic acid (NDGA)	4	5
Plantago major	1	5
Puerarin	3	5
Amygdalin	3	4
Astragaloside	3	4
Cannabinoids	4	4
Cannabinoids: Synthetic	2	4
Cinnamaldehyde	3	4
Hesperidin	3	4
Licorice	3	4
Magnolol	4	4
Maitake Mushroom	2	4
Olive leaf extract	3	4
Paeoniflorin	3	4
Panax Notoginseng	2	4
Saffron	2	4
Salvia miltiorrhiza	2	4
Turmeric	4	4
Vitamin E: alpha tocopherol	2	4
Artesunate	3	3
Beta-Caryophyllene	2	3
Biochanin A	2	3
Caffeic Acid	3	3
Chlorogenic Acid	2	3
Cinnamon	3	3
Citrus naringin	2	3
Ellagic Acid	2	3
Formononetin	3	3
Gallic Acid	2	3
Guduchi	2	3
Isoflavones	3	3
Mangosteen	2	3
Manuka Honey	3	3
Myricetin	3	3
Nobiletin	2	3
Oleanolic acid	2	3
Oleocanthal	2	3
Organosulfur Compounds	2	3
Phenethyl isothiocyanate	2	3
Piperlongumine	3	3
Propolis: Bee	2	3
Rosmarinic acid	3	3
Seaweed: Brown	2	3
Shikonin	3	3
Tangeretin	3	3
Thymol	3	3
Tomatidine	2	3
Vanillin	3	3
Vitamin B-12	2	3
Vitamin E	2	3
Vitamin E: Gamma-tocotrienol	3	3
Vitamin K	3	3
Wheat Grass	2	3
Zinc	3	3
Achillea fragrantissima	1	2
Allspice	1	2
Aloe Vera	2	2
Alpha-Lipoic Acid	1	2
Andrographolide	2	2
Apigenin	2	2
Arctigenin	2	2
Artemisinin	2	2
Ashwagandha	1	2
Astaxanthin	2	2
Banana	1	2
Basil	2	2
Berbamine	2	2
Beta Sitosterol	1	2
Beta-glucan	1	2
Black Tea	2	2
Bufalin	2	2
Capsaicin	2	2
Chlorella (Algae)	1	2
Chrysanthemum Indicum	1	2
Corn Silk	1	2
Crocin	2	2
Curcumol	2	2
Cyanidin 3-glucoside	1	2
DHA (Docosahexaenoic Acid)	2	2
Devils Claw	1	2
Elecampane	2	2
Evening Primrose Oil	1	2
False Black Pepper	1	2
Ferulic acid	2	2
Feverfew	1	2
Fucoxanthin	2	2
Garlic: Aged	1	2
Genipin	1	2
Geraniol	2	2
Germanium	2	2
Glycyrrhiza uralensis	1	2
Grape Seed Extract	2	2
Grapefruit	1	2
Green Coffee Bean	1	2
Griffithsin	2	2
Holy Basil	1	2
Hyperforin	1	2
Inulin	1	2
Isothiocyanates	2	2
L-Carnitine	1	2
Lactobacillus casei	1	2
Lactobacillus probiotics	1	2
Lactobacillus rhamnosus	1	2
Lemon Balm	1	2
Lemongrass	1	2
Lupeol	1	2
Magnesium	1	2
Mulberry	2	2
Myrrh	1	2
Nettle	1	2
Nisin	2	2
Onion	2	2
Oregano	2	2
Paeonol	2	2
Piceatannol	2	2
Pycnogenol (Pine Bark)	1	2
Resistant Starch	1	2
Rhubarb	1	2
Rooibos	1	2
Rosemaric Acid	1	2
Safflower	1	2
Silver (nanoparticles)	2	2
Silymarin	2	2
Sinomenine	1	2
Spikenard	1	2
Tetrahydrocurcumin	1	2
Thiamine (B-1)	2	2
Tocotrienol: Gamma	1	2
Valerian	1	2
Adlay	1	1
Antrodia cinnamomea	1	1
Asparagus	1	1
Beans: All	1	1
Benzyl isothiocyanate	1	1
Bergamot orange	1	1
Beta-sesquiphellandrene	1	1
Betel	1	1
Bitter Melon	1	1
Bixin	1	1
Black Currant	1	1
Black Raspberry	1	1
Blueberry	1	1
Breast Milk	1	1
Buckwheat	1	1
Burdock	1	1
Cafestol	1	1
Caffeic acid phenethyl ester	1	1
Carnosol	1	1
Carvacrol	1	1
Catechols	1	1
Cayenne	1	1
Celastrol	1	1
Celery seed	1	1
Chia	1	1
Chokeberry	1	1
Citral	1	1
Cruciferous Vegetables	1	1
Cucurbitacin B	1	1
Delta-tetrahydrocannabinol (THC)	1	1
Demethoxycurcumin	1	1
Diosmin	1	1
Elderberry	1	1
Epicatechin	1	1
Erucin	1	1
Feijoa	1	1
Fennel	1	1
Folic Acid	1	1
Fruit: All	1	1
Galbanic Acid	1	1
Geranium	1	1
Ginseng (Korean)	1	1
Glycyrrhizin	1	1
Goji	1	1
Gold (nanoparticles)	1	1
Grape	1	1
Haritaki (Terminalia chebula)	1	1
Harmine	1	1
Hibiscus sabdariffa	1	1
Homeopathic Medicine: All	1	1
Honeybush	1	1
Horse Chestnut	1	1
Iodine	1	1
Isomangiferin	1	1
Isoquercitrin	1	1
Kaempferol	1	1
Kudzu	1	1
L-arginine	1	1
Lactobacillus plantarum	1	1
Lactobacillus salivarius	1	1
Lichens	1	1
Lotus	1	1
Lutein	1	1
Magnolia	1	1
Maple Syrup	1	1
Modified Arabinoxylan Rice Bran (MGN-3)	1	1
Modified Citrus Pectin	1	1
Moringa oleifera	1	1
Myrtenol	1	1
Neem	1	1
Oleuropein	1	1
Olive	1	1
Patchouli	1	1
Pelargonium graveolens	1	1
Peppermint	1	1
Perilla	1	1
Phellinus Linteus	1	1
Phloretin	1	1
Plum	1	1
Pyrogallol	1	1
Reishi Mushroom	1	1
Riboflavin (Vitamin B-2)	1	1
Rice Bran	1	1
Rosemary	1	1
Rutin	1	1
Saikosaponin	1	1
Sea buckthorn	1	1
Seaweed	1	1
Sesamol	1	1
Tannic Acid	1	1
Theaflavins	1	1
Thyme	1	1
Tocotrienols	1	1
Tomato	1	1
Tripterygium wilfordii	1	1
Vegetables: All	1	1
Verbascoside	1	1
Vitamin A	1	1
Vitamin B-6	1	1
Vitamin C: Intravenous	1	1
Vitamin K2	1	1
Water: Deuterium Depleted	1	1
Watercress	1	1
White Button Mushroom	1	1
White Tea	1	1
Wild Quinine	1	1
beta-Carotene	1	1

Name	AC	CK
Exercise	1	10
Microbiota Transfer Therapy	1	10
Integrative Medicine	2	3
Dietary Modification: Low Carbohydrate/Ketogenic	1	2
Photobiomodulation	1	1

Name	AC	CK
Apoptotic	154	197
Anti-Bacterial Agents	121	196
Antiproliferative	153	195
Chemosensitizer	94	146
Anti-Inflammatory Agents	54	137
Chemotherapeutic	79	131
Antioxidants	48	123
Antidepressive Agents	10	68
Antiviral Agents	20	60
Neuroprotective Agents	20	60
Gastrointestinal Agents	14	57
Antimicrobial	43	53
Chemoprotective Agents	19	52
Hepatoprotective	13	52
Analgesics	15	50
Tumor Necrosis Factor (TNF) Alpha Inhibitor	14	48
Anti-metastatic	33	45
Antineoplastic Agents	35	44
Hypoglycemic Agents	14	41
Cell cycle arrest	32	40
Hypolipidemic	7	38
Antifungal Agents	25	36
NF-kappaB Inhibitor	22	34
Gastroprotective	9	32
Immunomodulatory	20	30
Interleukin-6 Downregulation	12	25
Renoprotective	13	25
Anticonvulsants	8	23
Chemopreventive	14	23
Interleukin-1 beta downregulation	9	22
Anticholesteremic Agents	3	21
Antinoceceptive	9	18
Bcl-2 protein down-regulation	11	18
Angiogenesis Inhibitors	13	17
Cyclooxygenase 2 Inhibitors	12	17
Cardioprotective	5	16
Matrix metalloproteinase-9 (MMP-9) inhibitor	10	15
Interleukin-8 downregulation	4	13
Vascular Endothelial Growth Factor Inhibitors	9	13
Anti-Angiogenic	8	12
Autophagy Up-regulation	6	11
Anti-atherogenic	1	10
Antiparasitic Agents	6	10
Insulin Sensitizers	1	10
Matrix metalloproteinase-2 (MMP-2) inhibitor	7	10
MicroRNA modulator	8	9
Anti-Ulcer Agents	4	8
Cyclin D1 Down-Regulation	3	8
Anti-Tumor	2	7
Leishmanicidal	4	7
Anti-Fibrotic	3	6
Malondialdehyde Down-regulation	3	6
Nrf2 activation	4	6
Anti-Retroviral Agents	1	5
Superoxide Dismutase Up-regulation	3	5
Tumor Suppressor Protein p53 Upregulation	5	5
Anticarcinogenic Agents	4	4
Brain-derived neurotrophic factor modulator	2	4
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	2	4
Interleukin-10 upregulation	2	4
Interleukin-12 upregulation	2	4
Osteoprotective	2	4
P21 Activation	3	4
Radiosensitizer	3	4
Anti-HIV Agents	3	3
Cyclooxygenase Inhibitors	2	3
Immunostimulatory	1	3
Vascular Endothelial Growth Factor A Inhibitor	2	3
AKT-mammalian target of rapamycin (mTOR) pathway inhibitor	1	2
Acetylcholinesterase Inhibitor	1	2
Alpha-glucosidase inhibitor	2	2
Angiogenesis Inducing Agents	1	2
Anthelmintics	1	2
Anti-Anxiety Agents	1	2
Anti-Apoptotic	2	2
Anti-Cachexic Agents	1	2
Catalase Up-Regulation	1	2
Cyclooxygenase 1 Inhibitor	1	2
Cytotoxic	2	2
Hypnotics and Sedatives	1	2
Interferon Gamma Reducer	1	2
Interleukin-10 downregulation	1	2
Interleukin-17 downregulation	1	2
Interleukin-4 downregulation	1	2
Multidrug Resistance Gene Modulators	2	2
Nitric Oxide Enhancer	1	2
Pancreato Protective Agents	1	2
Quorum Sensing Inhibition	2	2
Radioprotective	2	2
STAT3 Inhibitor	2	2
Survivin Down-Regulation	2	2
Vascular Endothelial Growth Factor C Inhibitor	1	2
Wnt/β-catenin signaling pathway modulation	2	2
apoptosis	1	2
Anti-Asthmatic Agents	1	1
Antimalarials	1	1
Appetite Stimulants	1	1
Bcl-xL down-regulation	1	1
Heat Shock Protein Inducer	1	1
Histone deacetylase inhibitor	1	1
Interleukin-12 downregulation	1	1
Interleukin-23 Downregulation	1	1
Photoprotective	1	1
Postaglandin PGE2 downregulation	1	1
Reactive Oxygen Species (ROS) attenuation	1	1
Reverse Transcriptase Inhibitors	1	1
SIRT1 Activator	1	1

Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Des Devel Ther. 2019 ;13:1969-1984. Epub 2019 Jun 17. PMID: 31354242

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Pubmed Data : Avicenna J Phytomed. 2017 Mar-Apr;7(2):129-136. PMID: 28348968

Article Published Date : Feb 28, 2017

Study Type : Human Study

Additional Links

Substances : Myrtle

Diseases : Bacterial Vaginosis

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Addition of epigallocatechin gallate 400 mg to sofosbuvir 400 mg + daclatisvir 60 mg in in treatment of patients with chronic hepatitis C.Jan 18, 2019

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Pubmed Data : Sci Rep. 2019 09 19 ;9(1):13593. Epub 2019 Sep 19. PMID: 31537880

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Pubmed Data : Pak J Med Sci. 2018 May-Jun;34(3):616-620. PMID: 30034426

Article Published Date : Apr 30, 2018

Study Type : Human In Vitro, Human Study

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Substances : Prunella vulgaris

Diseases : Escherichia coli Infections, Infection: Antibiotic Resistant, Urinary Tract Infections

Pharmacological Actions : Antimicrobial

Additional Keywords : Natural Substance/Drug Synergy

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Application of Peganum harmala seed can be useful in reducing urinary symptoms in patients with benign prostatic hyperplasia.Dec 31, 2016

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Helicobacter pylori eradication: Sequential therapy and Lactobacillus reuteri supplementation.Nov 20, 2012

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Pubmed Data : J Nutr. 2015 Apr ;145(4):749-57. Epub 2015 Feb 18. PMID: 25694068

Article Published Date : Mar 31, 2015

Study Type : Human Study

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Substances : Flaxseed

Diseases : Cholesterol: High, Peripheral Arterial Disease

Pharmacological Actions : Anticholesteremic Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

N-acetylcysteine combined with dexamethasone treatment improves sudden sensorineural hearing loss.Dec 31, 2020

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Pubmed Data : Am J Otolaryngol. 2020 Jul - Aug;41(4):102344. Epub 2019 Nov 12. PMID: 32487336

Article Published Date : Jul 31, 2020

Study Type : Human Study

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Substances : Echinacea

Diseases : Tonsillitis

Additional Keywords : Natural Substance/Drug Synergy

[+]

The effect of coenzyme Q10 plus trimetazidine on acute viral myocarditis treatment.Dec 31, 2020

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Pubmed Data : Mol Pharmacol. 2010 Nov ;78(5):855-64. Epub 2010 Aug 16. PMID: 20713551

Article Published Date : Oct 31, 2010

Study Type : Animal Study, Human In Vitro

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Substances : Amurensin G

Diseases : Breast Cancer: Drug Resistant, Cancers: Drug Resistant

Pharmacological Actions : Chemosensitizer

Additional Keywords : Gene Expression Regulation, Natural Substance/Drug Synergy, Plant Extracts

Problem Substances : Doxorubicin

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Pubmed Data : J Exp Clin Cancer Res. 2016 Feb 13 ;35:32. Epub 2016 Feb 13. PMID: 26872471

Article Published Date : Feb 12, 2016

Study Type : Animal Study, In Vitro Study

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Substances : Ginsenosides

Diseases : Glioblastoma

Pharmacological Actions : Anti-Angiogenic, Antiproliferative , Cell cycle arrest

Additional Keywords : Natural Substance/Drug Synergy

[+]

AGE showed synergistic effects with NTX on inhibition of tumor growth and increment of survival times.Jun 30, 2013

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Combination of curcumin and mitomycin C can synergistically inhibit tumor growth in MCF-7 breast cancer xenografts and induce apoptosis in breast cancer MCF-7 cells.Dec 31, 2013

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Pubmed Data : Int J Mol Sci. 2014 ;15(9):16284-301. Epub 2014 Sep 15. PMID: 25226537

Article Published Date : Dec 31, 2013

Study Type : Animal Study, In Vitro Study

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Substances : Curcumin

Diseases : Breast Cancer

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemotherapeutic

Additional Keywords : Drug: Mitomycin, Natural Substance/Drug Synergy

[+]

Combination of erythromycin and curcumin alleviates Staphylococcus aureus induced osteomyelitis.Dec 31, 2016

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Pubmed Data : Altern Ther Health Med. 2018 Sep ;24(5):33-43. PMID: 28987074

Article Published Date : Aug 31, 2018

Study Type : Animal Study

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Substances : Rhubarb

Diseases : Allodynia, Hyperalgesia

Pharmacological Actions : Antinoceceptive , Antioxidants, Hypoglycemic Agents

Additional Keywords : Natural Substance/Drug Synergy, Phytotherapy, Plant Extracts

[+]

Combination therapy of carnosic acid and methotrexate effectively suppressed the inflammatory markers and oxidative stress in experimental arthritis.Oct 20, 2022

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Distinct interactions of cannabidiol and morphine in three nociceptive behavioral models in mice.Mar 31, 2015

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Pubmed Data : Behav Pharmacol. 2015 Apr ;26(3):304-14. PMID: 25485642

Article Published Date : Mar 31, 2015

Study Type : Animal Study

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Substances : Cannabidiol

Additional Keywords : Natural Substance/Drug Synergy

[+]

Effect of curcumin-donepezil combination on spatial memory, astrocyte activation, and cholinesterase expressions in brain of scopolamine-treated rats.Jul 28, 2024

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Pubmed Data : Mol Biol Rep. 2024 Jul 29 ;51(1):864. Epub 2024 Jul 29. PMID: 39073463

Article Published Date : Jul 28, 2024

Study Type : Animal Study

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Substances : Curcumin

Diseases : Cognitive Decline/Dysfunction, Oxidative Stress

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Effects of azithromycin and Chlorella vulgaris treatment on certain cytokine values and NK cell activity in an acute murine toxoplasmosis model.Dec 31, 2016

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Pubmed Data : Mikrobiyol Bul. 2017 Jan ;51(1):52-61. PMID: 28283010

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Pubmed Data : Eur J Pharmacol. 2014 Oct 15 ;741:272-80. Epub 2014 Aug 30. PMID: 25179576

Article Published Date : Oct 14, 2014

Study Type : Animal Study

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Substances : Ellagic Acid

Diseases : Morphine Tolerance/Dependence

Additional Keywords : Natural Substance/Drug Synergy

[+]

Embelin protects against acute pentylenetetrazole-induced seizures and positively modulates cognitive function.Dec 31, 2018

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Pubmed Data : Front Pharmacol. 2019 ;10:1249. Epub 2019 Oct 25. PMID: 31708779

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : False Black Pepper

Diseases : Seizures: Drug-Induced

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Endostar combined with ginsenoside Rg3 has stronger inhibiting effect on breast cancer tumor growth in tumor-bearing mice than single drug.Jan 31, 2016

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Pubmed Data : Front Microbiol. 2017 ;8:2271. Epub 2017 Nov 17. PMID: 29204141

Article Published Date : Dec 31, 2016

Study Type : Animal Study

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Substances : Honeysuckle

Diseases : Diabetes Mellitus: Type 2, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Gastrointestinal Agents, Hepatoprotective, Hypoglycemic Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Fluoxetine and wheatgrass combination demonstrated a more significant neuroprotective impact in treating Alzheimer's disease.Nov 07, 2021

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Pubmed Data : Molecules. 2021 Nov 8 ;26(21). Epub 2021 Nov 8. PMID: 34771159

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Pubmed Data : Iran J Basic Med Sci. 2020 Aug ;23(8):1035-1044. PMID: 32952950

Article Published Date : Jul 31, 2020

Study Type : Animal Study

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Substances : L-Carnitine

Diseases : Inflammation, Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Diclofenac

[+]

Lactobacillus casei improve anti-tuberculosis drugs-induced intestinal adverse reactions.Apr 16, 2022

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Pubmed Data : Cancer Cell Int. 2019 ;19:68. Epub 2019 Mar 21. PMID: 30948928

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Lycopene

Diseases : Lung Cancer

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Mangosteen ethanol extract alleviated the severity of collagen-induced arthritis in rats and produced synergistic effects with methotrexate.Nov 30, 2018

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Pubmed Data : Life Sci. 2021 Dec 15 ;287:120085. Epub 2021 Oct 23. PMID: 34699905

Article Published Date : Dec 14, 2021

Study Type : Animal Study

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Diseases : Salmonella Infections

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Pioglitazone plus nettle has synergistic protective effects against STZ-induced nephropathy.Apr 30, 2017

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Pubmed Data : Iran J Basic Med Sci. 2017 May ;20(5):497-502. PMID: 28656084

Article Published Date : Apr 30, 2017

Study Type : Animal Study

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Substances : Nettle

Diseases : Diabetic Nephropathy

Pharmacological Actions : Antioxidants, Renoprotective

Additional Keywords : Natural Substance/Drug Synergy

[+]

Pomegranate peel extract, N-Acetylcysteine and their combination with Ornipural alleviate Cadmium-induced toxicity.Sep 06, 2023

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Pubmed Data : Gen Physiol Biophys. 2022 Sep ;41(5):473-481. PMID: 36222345

Article Published Date : Aug 31, 2022

Study Type : Animal Study

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Substances : Flavonoids, Pycnogenol (Pine Bark)

Diseases : Drug-Induced Toxicity: Indomethacin

Pharmacological Actions : Anti-Inflammatory Agents, Anti-Ulcer Agents, Cyclooxygenase 1 Inhibitor, Gastrointestinal Agents, Gastroprotective, Malondialdehyde Down-regulation

Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts

Problem Substances : Indomethacin

[+]

Quercetin could be a favourable antifungal agent and a promising synergist with fluconazole.Nov 29, 2016

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Pubmed Data : Int J Mol Med. 2015 Aug ;36(2):363-8. Epub 2015 Jun 17. PMID: 26080893

Article Published Date : Jul 31, 2015

Study Type : Animal Study

Additional Links

Substances : Lactoferrin

Diseases : Helicobacter Pylori Infection, Inflammation

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Renoprotective effect of a novel combination of 6-gingerol and metformin in high-fat diet/streptozotocin-induced diabetic nephropathy.Jul 19, 2024

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Synergistic effect of chlorogenic acid and levofloxacin against Klebsiella pneumonia infection.Jan 16, 2020

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Pubmed Data : J Agric Food Chem. 2022 Jan 19. Epub 2022 Jan 19. PMID: 35044756

Article Published Date : Jan 18, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Anthocyanins

Diseases : Hyperglycemia

Pharmacological Actions : Gastrointestinal Agents, Hypoglycemic Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Synergistic effects of magnesium ions and simvastatin on attenuation of high-fat diet-induced bone loss.Jul 31, 2021

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Pubmed Data : Parasitol Res. 2015 Oct 7. Epub 2015 Oct 7. PMID: 26446086

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Pubmed Data : J Microbiol Immunol Infect. 2022 Aug ;55(4):757-765. Epub 2022 May 17. PMID: 35654701

Article Published Date : Jul 31, 2022

Study Type : Animal Study

Additional Links

Substances : Wogonin

Diseases : Schistosomiasis

Pharmacological Actions : Anthelmintics

Additional Keywords : Natural Substance/Drug Synergy

[+]

Valerenic acid and valerian extracts have anticonvulsant properties in adult zebrafish. Jul 13, 2015

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A lethal synergy induced by phellinus linteus and camptothecin11 in colon cancer cells.Jan 18, 2018

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Pubmed Data : Eur J Pharmacol. 2015 Jun 3 ;762:283-292. Epub 2015 Jun 3. PMID: 26048310

Article Published Date : Jun 02, 2015

Study Type : In Vitro Study

Additional Links

Substances : Emodin

Diseases : Melanoma, Melanoma: Metastatic

Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemotherapeutic, Immunomodulatory

Additional Keywords : Natural Substance/Drug Synergy

[+]

Amygdalin exerts antitumor activity in taxane-resistant prostate cancer cells. Jun 23, 2022

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Pubmed Data : Cancer Biother Radiopharm. 2008 Oct ;23(5):647-53. PMID: 18999937

Article Published Date : Sep 30, 2008

Study Type : In Vitro Study

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Substances : Ginsenosides

Diseases : Breast Cancer

Pharmacological Actions : Anti-Angiogenic, Chemotherapeutic, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Natural Substance/Drug Synergy

[+]

Antibacterial activities of Agaricus bisporus extracts and their synergistic effects with the antistaphylococcal drug AFN-1252.May 29, 2024

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Pubmed Data : Foods. 2024 May 30 ;13(11). Epub 2024 May 30. PMID: 38890946

Article Published Date : May 29, 2024

Study Type : In Vitro Study

Additional Links

Substances : White Button Mushroom

Diseases : Bacillus subtilis infections, Escherichia coli Infections, Staphylococcus aureus: Methicillin-resistant (MRSA), Staphylococcus aureus infection

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy

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View the Evidence: 729 Abstracts with Natural Substance/Drug Synergy Research

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Ginkgo biloba preparations plus donepezil can improve clinical effectiveness rate and vocabulary memory outcomes.Dec 31, 2022

Ginseng-containing traditional medicine preparations in combination with fluoropyrimidine-based chemotherapy for advanced gastric cancer.Dec 31, 2022

A review of the beneficial effects of antioxidants on Helicobacter pylori eradication.Nov 30, 2018

Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis.Dec 31, 2018

Honeysuckle combined with conventional therapy may be beneficial for the treatment of COVID-19 in improving lung CT, clinical cure rate, clinical symptoms.Dec 31, 2020

Specific combinations of traditional medicines appeared to produce higher contributions to tumor response rate than the TMs individually.Aug 05, 2015

The addition of probiotics to standard therapy is associated with improved H. pylori eradication rates in both children and adults.Dec 31, 2015

Bee products are effective in symptomatic treatment of upper respiratory tract infections.Dec 31, 2019

Probiotic Bifidobacterium longum supplied with methimazole improved the thyroid function of Graves' disease patients through the gut-thyroid axis Jan 06, 2021

"Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer."Feb 28, 2011

Adding 100 g of almonds daily to chronic statin therapy for 4 weeks significantly reduced non-HDL-C.Dec 31, 2014

Adding Berberis vulgaris fruit extract on metronidazole improve the efficacy of bacterial vaginosis therapy.Jul 31, 2016

Adding M. communis extract to metronidazole increases the efficiency of bacterial vaginosis treatment.Feb 28, 2017

Addition of epigallocatechin gallate 400 mg to sofosbuvir 400 mg + daclatisvir 60 mg in in treatment of patients with chronic hepatitis C.Jan 18, 2019

Adjuvant palmitoylethanolamide therapy with risperidone improves negative symptoms in patients with schizophrenia.Sep 30, 2022

Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection.Nov 20, 2012

Antimicrobial activity of Prunella Vulgaris extracts against multi-drug resistant Escherichia Coli from patients of urinary tract infection.Apr 30, 2018

Application of Peganum harmala seed can be useful in reducing urinary symptoms in patients with benign prostatic hyperplasia.Dec 31, 2016

Black cumin seeds decreased Methotrexate hepatotoxicity and improved survival in children with ALLMar 19, 2015

Cannabis users report greater pain relief in combination with opioids than when opioids are used alone.Jan 31, 2015

Citicoline add-on therapy to risperidone can effectively improve the primary negative symptoms of patients with schizophrenia.Jun 30, 2018

Citicoline was an effective adjuvant to citalopram in the therapy of major depressive disorder.Dec 31, 2016

Clinical efficacy of acetylcysteine combined with tetrandrine tablets on patients with silicosis.Jul 31, 2020

Curcumin could reverse the development of depression and enhance the outcome of antidepressants treatment in major depressive disorder.Jul 31, 2015

Curcumin may be a safe and effective therapy for maintenance of remission in quiescent UC when given as adjunctive therapy along with mesalamine or sulfasalazine. Dec 31, 2011

Curcuminoids with piperine may be used as a safe and effective add on to standard antidepressants in patients with major depressive disorders.Dec 31, 2014

Effective analgesic between acetominophen + B vitamins vs. acetominophen in pediatric ambulatory surgery.Dec 31, 2009

Effects of metformin and curcumin in women with polycystic ovary syndrome.Nov 30, 2024

Efficacy and tolerance of cannabidiol in the treatment of epilepsy in patients with Rett syndrome.Jul 23, 2023

Fecal microbiota transplantation plus tislelizumab and fruquintinib in refractory microsatellite stable metastatic colorectal cancer.Nov 30, 2023

Helicobacter pylori eradication: Sequential therapy and Lactobacillus reuteri supplementation.Nov 20, 2012

L-Theanine adjunct to risperidone in the treatment of chronic schizophrenia inpatients.Nov 30, 2023

Lavandula angustifilia infusion has some positive therapeutic effects on depressed patients most importantly decreases mean depression score and might be used alone or as an adjunct to other anti-depressant drugs.Jul 31, 2013

Milled flaxseed lowers total and LDL cholesterol in patients with peripheral artery disease.Mar 31, 2015

N-acetylcysteine combined with dexamethasone treatment improves sudden sensorineural hearing loss.Dec 31, 2020

Novel bioenhanced curcumin with mesalamine for induction of clinical and endoscopic remission in mild-to-moderate ulcerative colitis.Aug 31, 2021

Palmitoylethanolamide and acetyl-L-carnitine act synergistically with duloxetine and pregabalin in fibromyalgia.May 31, 2023

Preparation and optimization of garlic oil/apple vider vinegar nanoemulsion loaded with minoxidil to treat alopecia.Dec 13, 2021

Prunella vulgaris may be a potential adjuvant medicine for breast cancer treatment.Dec 31, 2017

Resveratrol adjunct to methylphenidate improves symptoms of attention-deficit/hyperactivity disorder.Apr 30, 2021

Silibinin may improve the effects of methotrexate on certain biochemical and clinical markers of patients with active rheumatoid arthritis.Jun 30, 2016

Somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide led to an overall clinical benefit been achieved in 75% of cases.Dec 31, 2012

Synergism of allicin in combination with itraconazole and terbinafine, which could be a reference for the treatment of tinea capitis due to M. canis.Dec 31, 2020

The addition of POMx to simvastatin therapy in hypercholesterolemic patients improved oxidative stress and lipid status in the patient's serum and in their HMDM. Dec 31, 2013

The administration of soybean could enhance the response to SSRI anti depressants in menopausal women.Feb 28, 2014

The administration of soybean could enhance the response to SSRI anti depressants in menopausal women.Feb 28, 2014

The combination of bevacizumab and tocotrienol is potent in chemotherapy refractory ovarian cancer. Feb 28, 2019

The combination of serenoa repens, selenium, lycopene and bromelain are beneficial in patients with chronic bacterial prostatitis.Oct 04, 2016

The combined use of echinacea with azithromycin produced favourable outcome than azithromycin alone in pediatric patients with recurrent tonsillitis.Jul 31, 2020

The effect of coenzyme Q10 plus trimetazidine on acute viral myocarditis treatment.Dec 31, 2020

The efficacy of curcuminoids in improvement of ulcerative colitis symptoms and patients' self-reported well-being.Oct 31, 2018

The potential prebiotic berberine combined with methimazole improved the therapeutic effect of Graves' disease patients.Dec 31, 2020

The present study encourages the role of combined administration in disease management by slowing disease progression.Dec 31, 2016

Therapeutic effect of curcumin in women with polycystic ovary syndrome receiving metformin.Dec 31, 2020

Vitamin D supplementation improves the therapeutic effect of mometasone on allergic rhinitis.Sep 15, 2023

6-shogaol, 6-gingerol and pterostilbene selectively killed breast cancer stem cells.Mar 10, 2015

Amurensin G. was a potent SIRT1 Inhibitor which led to the down regulation of multidrug resistance.Oct 31, 2010

Combinations of EGCG and anticancer compounds induced synergistic anticancer effects in vitro and in vivo experiments, and showed an average reduction in tumor volume by 70.3 %.Aug 31, 2015

Findings suggest that Plantago ovata husk could be a potentially useful adjuvant in chemotherapy for colorectal cancer.Jun 01, 2012

Hydrocortisone and ascorbic acid synergistically prevent and repair lipopolysaccharide-induced pulmonary endothelial barrier dysfunction.Jan 10, 2017

Piperine enhanced mitomycin-C therapy in human cervical cancer cells.Nov 19, 2017

Prunella vulgaris has potent anti-Ebola virus activity and may be developed as a novel antiviral approach against EBOV infection.Feb 29, 2016

Pterostilbene might be used to modulate two anticancer compounds in well-defined sets of GBM patients.Nov 07, 2016

The combination of centchroman with genistein has selective cytotoxic effect for human breast cancer cell lines.Oct 31, 2016

These results suggest deguelin could have potential for the treatment of human CLL.Dec 31, 2015

Ursolic acid enhances the sensitivity of MCF-7 and MDA-MB-231 cells to epirubicin.May 24, 2022

Baicalin acts as an adjuvant to potentiate the activity of azithromycin against Staphylococcus saprophyticus biofilm: an in vitro, in vivo, and molecular study.Oct 11, 2022

Beetroot-carrot juice can be used as an effective treatment for CLL alone or in combination with chlorambucil.Jun 14, 2015

Curcumin enhances bedaquiline's efficacy against Mycobacterium abscessus.Mar 17, 2025

Dihydrotanshinone I is effective against drug-resistant Helicobacter pylori.Feb 16, 2021

Eugenol works synergistically with colistin against colistin-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae.Sep 13, 2023

Fucoidan enhances the chemotherapeutic sensitivity of capecitabine in colon cancer Sep 24, 2022

Natural Substance/Drug Synergy

View the Evidence:
729 Abstracts with Natural Substance/Drug Synergy Research