Natural Substance/Drug Synergy

Name	AC	CK
Antibiotics	8	28
Fluoxetine (trade name Prozac)	2	20
Methotrexate	1	20
Sertraline	2	20
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	2	11
Antidepressants	1	10
Mesalamine	1	10
Simvastatin	1	10
Statin Drugs	1	10
Doxorubicin	2	7
Cisplatin	2	4
Diclofenac	2	4
Fluorouracil (5-FU or f5U)	1	2
Glibenclamide	1	2
Nicotine	1	2
Oseltamivir (trade name Tamiflu)	1	2
Paclitaxel	1	2
Prednisolone	1	2
Zoledronic Acid	1	2
Atorvastatin	1	1
Dexamethasone	1	1
Herceptin	1	1
Indomethacin	1	1

Name	AC	CK
Breast Cancer	52	87
Helicobacter Pylori Infection	12	69
Depression	8	56
Colorectal Cancer	19	47
Rheumatoid Arthritis	5	34
Staphylococcus aureus infection	29	31
Cancers: All	23	28
Escherichia coli Infections	17	26
Cancers: Drug Resistant	18	25
Lung Cancer	17	24
Oxidative Stress	10	24
Breast Cancer: Triple Negative	16	23
Candida Albicans	20	22
Liver Cancer	17	22
Infection: Antibiotic Resistant	12	21
Ovarian Cancer	6	21
Pseudomonas aeruginosa	20	21
Bacterial Vaginosis	2	20
Depression: Postmenopausal	2	20
Diarrhea: Antibiotic-Associated	1	20
Colon Cancer	14	17
Staphylococcus aureus: Methicillin-resistant (MRSA)	15	16
Chronic Pain	4	15
Chemotherapy-Induced Toxicity: Cyclophosphamide	3	14
Acute lymphoblastic leukemia (ALL)	3	12
Carcinoma: Non-Small-Cell Lung	9	12
Cervical Cancer	7	12
Melanoma	9	12
Multiple Myeloma	9	12
Ulcerative Colitis	2	11
Anxiety Disorders	1	10
Atherosclerosis	1	10
Breast Cancer: Metastatic	1	10
C-Reactive Protein	1	10
Cholesterol: High	1	10
Colorectal Adenomas	1	10
Depressive Disorder	1	10
Drug-Induced Toxicity: Methotrexate	1	10
Gastric Cancer	7	10
Hearing Loss: Sudden	1	10
High Cholesterol	1	10
Inflammation	7	10
Leukemia	10	10
Neuropathic Pain	5	10
Peripheral Arterial Disease	1	10
Prostate Cancer	8	10
Prostatic Hyperplasia	1	10
Prostatitis: Bacterial	1	10
Silicosis	1	10
Tonsillitis	1	10
Triglycerides: Elevated	1	10
Upper Respiratory Infections	1	10
Urinary Tract Infections	1	10
Candida Infection	8	8
Diabetes Mellitus: Type 2	4	8
Glioblastoma	7	8
Sepsis	3	8
Arthritis	4	7
Chronic Lymphocytic Leukemia	3	7
Glioma	5	7
Mycobacterium tuberculosis	7	7
Pancreatic Cancer	6	7
Acinetobacter baumannii infection	6	6
Allodynia	3	6
Breast Cancer Stem Cells	2	6
Breast Cancer: Drug Resistant	2	6
Glioblastoma Multiforme	2	6
Klebsiella Infections	5	6
Skin Cancer	4	6
Ebola Virus Infections	1	5
Endothelial Dysfunction	1	5
Lipopolysaccharide-Induced Toxicity	1	5
Acute Myeloid Leukemia	4	4
Alzheimer's Disease	3	4
Esophageal Cancer	3	4
Hyperalgesia	2	4
Hyperglycemia	2	4
Lipid Peroxidation	2	4
Lymphoma: B-Cell	2	4
Malignant Melanoma	2	4
Promyelocytic leukemia	4	4
Seizures: Drug-Induced	2	4
Toxoplasma gondii Infection	2	4
Bacterial Infections	3	3
Cachexia: Cancer	2	3
Cancer Metastasis	2	3
Cancers: Multi-Drug Resistant	3	3
Chemotherapy-Induced Toxicity	2	3
Chemotherapy-Induced Toxicity: Bleomycin	2	3
Chemotherapy-Induced Toxicity: Cisplatin	2	3
Coronavirus Infection	3	3
Epilepsy	2	3
HIV Infections	3	3
Leishmaniasis	2	3
Leukemia: Chronic Lymphocytic Leukemia (CLL)	1	3
Mastocytosis	1	3
Osteosarcoma	3	3
Salmonella Infections	2	3
Staphylococcus epidermidis	3	3
Trypanosomiasis	2	3
Wound Healing	2	3
Aspirin-Induced Toxicity	1	2
Campylobacter Infections	2	2
Candida Glabrata	2	2
Candidiasis	1	2
Candidiasis: Vulvovaginal	1	2
Cardiotoxicity: Chemotherapy-Induced	1	2
Chagas Disease	1	2
Chemotherapy and Radiation Toxicity	1	2
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	2
Choriocarcinoma	2	2
Cognitive Decline/Dysfunction	1	2
Colitis	1	2
Cryptococcosis	1	2
Diabetic Complications	1	2
Diabetic Nephropathy	1	2
Dyslipidemias	1	2
Enterococcus Infections	2	2
Fibrosarcoma	1	2
Gastric Ulcer	1	2
Gram-Negative Bacterial Infections	2	2
Gram-Positive Bacterial Infections	2	2
Hyperlipidemia	1	2
Inflammatory Bowel Diseases	1	2
Influenza	1	2
Influenza A	1	2
Kidney Cancer	2	2
Kidney Damage: Chemically-Induced	1	2
Kidney Damage: Drug-Induced	1	2
Klesiella Pneumonia Infection	1	2
Laryngeal Cancer	2	2
Leukemia: Chronic myelogenous leukemia (CML)	2	2
Liver Metastasis From Colon Cancer	1	2
Memory Loss	1	2
Morphine Tolerance/Dependence	1	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Osteoarthritis	1	2
Osteoporosis	1	2
Parasitic Diseases	1	2
Seizures	1	2
Sleep Disorders	1	2
Spinal Cord Injuries	1	2
Squamous cell carcinoma	2	2
Steptococcus Mutans Infections	2	2
Toxoplasmosis	1	2
AIDS	1	1
Animal Cancers	1	1
Autoimmune Diseases	1	1
Bacterial Infections: Resistance/Biofilm Formation	1	1
Bladder Cancer	1	1
Bone Cancer	1	1
Brain Cancer	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Cancer: Pain	1	1
Cancers: Canine	1	1
Carcinosarcomas	1	1
Cardiovascular Disease	1	1
Chemotherapy	1	1
Chemotherapy-Induced Toxicity: Doxorubicin	1	1
Chemotherapy-Induced Toxicity: Tamoxifen	1	1
Cystic Fibrosis	1	1
Cytomegalovirus Infections	1	1
Diabesity	1	1
Epileptic Seizures	1	1
Fungal Infection	1	1
Fungal Infections: Biofilm Formation/Resistance	1	1
Fungus Diseases	1	1
Head and Neck Cancer	1	1
Headache	1	1
Hepatitis B	1	1
Hepatitis C	1	1
Herpes Simplex Virus Type 1	1	1
Herpes Simplex Virus Type 2	1	1
Hypoglycemia	1	1
Leukemia: Acute myelogenous leukemia (AML)	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Listeria Infections	1	1
Lyme Borreliosis	1	1
Lyme Disease	1	1
Malaria	1	1
Measles	1	1
Medulloblastoma	1	1
Melanoma: Metastatic	1	1
Multiple Sclerosis	1	1
Mycobacterium abscessus	1	1
Neurofibromatosis	1	1
Non-Hodgkin's lymphoma: B Cell	1	1
Oral Cancer	1	1
Parkinson's Disease	1	1
Periodontal Diseases	1	1
Peripheral Neuropathies	1	1
Radiation Induced Illness	1	1
Retinoblastoma	1	1
Rhabdomyosarcoma	1	1
Schwannoma	1	1
Spondylitis: Ankylosing	1	1
Staphylococcal Infections	1	1
Streptococcus pyogenes	1	1
Tuberculosis: Drug Resistant	1	1

Name	AC	CK
Curcumin	39	95
NAC (N-acetyl-L-cysteine)	8	49
Vitamin C	30	44
Probiotics	3	31
Prunella vulgaris	3	25
EGCG (Epigallocatechin gallate)	17	24
Vitamin D	11	22
Berberine	19	21
Chinese Skullcap	2	21
Astragalus	1	20
Cranberry	1	20
Hedyotis corymbosa	1	20
Peony	1	20
Soy	2	20
Quercetin	15	18
Melatonin	7	17
Pomegranate	6	16
Ginsenosides	10	15
Silibinin	6	15
Bee Propolis	4	14
Nigella sativa (aka Black Seed)	3	14
Fucoidan	4	13
Pterostilbene	5	13
Cannabis	3	12
Lycopene	2	12
Bromelain	2	11
Echinacea	2	11
Green Tea	5	11
Barberry	1	10
Bee Products	1	10
Flaxseed	1	10
Honey	1	10
Lactobacillus reuteri	1	10
Lavender	1	10
Myrtle	1	10
Piperidines	1	10
Royal Jelly	1	10
Saw Palmetto	1	10
Selenium	1	10
Syrian rue	1	10
Tocotrienol: Delta	1	10
Bee Venom	7	9
Piperine	5	9
Thymoquinone	7	9
Cannabidiol	7	8
Catechin	4	8
Mangiferin	6	8
Oridonin	7	8
Parthenolide	7	8
Resveratrol	7	8
Gingerol	3	7
Honokiol	6	7
Polyphenols	7	7
Tanshinone IIA	5	7
Wogonin	4	7
Carnosic Acid	4	6
Genistein	2	6
Luteolin	5	6
Sulforaphane	5	6
6-Shogaol	1	5
Amurensin G	1	5
Carrot	2	5
Deguelin	1	5
Garlic	5	5
Nordihydroguaiaretic acid (NDGA)	4	5
Plantago major	1	5
Beet	2	4
Beta-Elemene	4	4
Cannabinoids	4	4
Cannabinoids: Synthetic	2	4
Emodin	4	4
Ginkgo biloba	3	4
Indole-3-Carbinol	4	4
Lactoferrin	3	4
Olive leaf extract	3	4
Turmeric	4	4
Vitamin E: alpha tocopherol	2	4
Anthocyanins	2	3
Artesunate	3	3
Baicalein	3	3
Beta-Caryophyllene	2	3
Betulinic acid	2	3
Biochanin A	2	3
Caffeic Acid	3	3
Chlorogenic Acid	2	3
Chrysin	2	3
Cinnamaldehyde	2	3
Cinnamon	3	3
Gallic Acid	2	3
Ginger	3	3
Guduchi	2	3
Hesperidin	2	3
Magnolol	3	3
Mangosteen	2	3
Nobiletin	2	3
Oleocanthal	2	3
Puerarin	2	3
Rosmarinic acid	3	3
Tomatidine	2	3
Vitamin E: Gamma-tocotrienol	3	3
Vitamin K	3	3
Achillea fragrantissima	1	2
Allicin	2	2
Allspice	1	2
Ashwagandha	1	2
Astaxanthin	2	2
Banana	1	2
Basil	2	2
Beta-glucan	1	2
Black Tea	2	2
Bufalin	2	2
Capsaicin	2	2
Chrysanthemum Indicum	1	2
Corn Silk	1	2
Curcumol	2	2
Cyanidin 3-glucoside	1	2
DHA (Docosahexaenoic Acid)	2	2
Dandelion	1	2
Devils Claw	1	2
Ellagic Acid	1	2
Eugenol	2	2
Evening Primrose Oil	1	2
False Black Pepper	1	2
Ferulic acid	2	2
Feverfew	1	2
Formononetin	2	2
Garlic: Aged	1	2
Genipin	1	2
Geraniol	2	2
Ginseng	1	2
Grape Seed Extract	2	2
Grapefruit	1	2
Honeysuckle	1	2
Hyperforin	1	2
Isothiocyanates	2	2
L-Carnitine	1	2
Lemongrass	1	2
Magnesium	1	2
Maitake Mushroom	1	2
Manuka Honey	2	2
Myricetin	2	2
Myrrh	1	2
Naringenin	1	2
Nettle	1	2
Onion	2	2
Oregano	2	2
Palmitoylethanolamide	1	2
Panax Notoginseng	1	2
Phenethyl isothiocyanate	1	2
Piperlongumine	2	2
Punicalagin	2	2
Resistant Starch	1	2
Rhubarb	1	2
Rooibos	1	2
Safflower	1	2
Silver (nanoparticles)	2	2
Silymarin	2	2
Spikenard	1	2
Tangeretin	2	2
Tetrahydrocurcumin	1	2
Theanine	1	2
Thiamine (B-1)	2	2
Tocotrienol: Gamma	1	2
Ursolic Acid	2	2
Valerian	1	2
Vanillin	2	2
Vitamin E	1	2
Zinc	2	2
Adlay	1	1
Aloe Vera	1	1
Antrodia cinnamomea	1	1
Arctigenin	1	1
Artemisinin	1	1
Asparagus	1	1
Astragaloside	1	1
Beans: All	1	1
Benzyl isothiocyanate	1	1
Bergamot orange	1	1
Beta-sesquiphellandrene	1	1
Bitter Melon	1	1
Black Currant	1	1
Blueberry	1	1
Breast Milk	1	1
Burdock	1	1
Cafestol	1	1
Caffeic acid phenethyl ester	1	1
Carnosol	1	1
Carvacrol	1	1
Cayenne	1	1
Celastrol	1	1
Celery seed	1	1
Chia	1	1
Chokeberry	1	1
Citral	1	1
Citrus naringin	1	1
Crocin	1	1
Cruciferous Vegetables	1	1
Cucurbitacin B	1	1
Delta-tetrahydrocannabinol (THC)	1	1
Demethoxycurcumin	1	1
Diosmin	1	1
Epicatechin	1	1
Erucin	1	1
Feijoa	1	1
Folic Acid	1	1
Fruit: All	1	1
Fucoxanthin	1	1
Galbanic Acid	1	1
Ginseng (Korean)	1	1
Glycyrrhizin	1	1
Gold (nanoparticles)	1	1
Grape	1	1
Griffithsin	1	1
Haritaki (Terminalia chebula)	1	1
Hibiscus sabdariffa	1	1
Homeopathic Medicine: All	1	1
Honeybush	1	1
Iodine	1	1
Isomangiferin	1	1
Isoquercitrin	1	1
Kaempferol	1	1
Kudzu	1	1
L-arginine	1	1
Lichens	1	1
Lutein	1	1
Magnolia	1	1
Maple Syrup	1	1
Modified Arabinoxylan Rice Bran (MGN-3)	1	1
Modified Citrus Pectin	1	1
Mulberry	1	1
Oleanolic acid	1	1
Oleuropein	1	1
Olive	1	1
Paeonol	1	1
Pelargonium graveolens	1	1
Peppermint	1	1
Perilla	1	1
Phellinus Linteus	1	1
Phloretin	1	1
Piceatannol	1	1
Plum	1	1
Propolis: Bee	1	1
Pyrogallol	1	1
Riboflavin (Vitamin B-2)	1	1
Rice Bran	1	1
Rosemary	1	1
Salvia miltiorrhiza	1	1
Sea buckthorn	1	1
Seaweed	1	1
Seaweed: Brown	1	1
Sesamol	1	1
Shikonin	1	1
Tannic Acid	1	1
Theaflavins	1	1
Thyme	1	1
Tocotrienols	1	1
Tomato	1	1
Vegetables: All	1	1
Vitamin A	1	1
Vitamin B-12	1	1
Vitamin B-6	1	1
Vitamin C: Intravenous	1	1
Vitamin K2	1	1
Watercress	1	1
Wheat Grass	1	1
White Tea	1	1
beta-Carotene	1	1

Name	AC	CK	Focus
Exercise	1	10
Integrative Medicine	2	3

Name	AC	CK
Antiproliferative	115	152
Apoptotic	115	150
Anti-Bacterial Agents	71	130
Chemotherapeutic	69	110
Chemosensitizer	68	109
Antioxidants	31	96
Anti-Inflammatory Agents	33	92
Antidepressive Agents	8	56
Antimicrobial	37	47
Antineoplastic Agents	31	39
Anti-metastatic	28	38
Cell cycle arrest	28	36
Hepatoprotective	4	34
Tumor Necrosis Factor (TNF) Alpha Inhibitor	9	31
Chemoprotective Agents	17	30
NF-kappaB Inhibitor	20	30
Gastroprotective	5	26
Antiviral Agents	14	25
Analgesics	8	21
Chemopreventive	11	19
Interleukin-6 Downregulation	8	18
Immunomodulatory	12	17
Angiogenesis Inhibitors	12	16
Interleukin-1 beta downregulation	5	16
Matrix metalloproteinase-9 (MMP-9) inhibitor	10	15
Antifungal Agents	12	14
Bcl-2 protein down-regulation	8	14
Cyclooxygenase 2 Inhibitors	10	14
Hypoglycemic Agents	8	14
Anti-Angiogenic	8	12
Antinoceceptive	6	12
Interleukin-8 downregulation	3	12
Vascular Endothelial Growth Factor Inhibitors	7	11
Anti-atherogenic	1	10
Anticholesteremic Agents	1	10
Hypolipidemic	1	10
Matrix metalloproteinase-2 (MMP-2) inhibitor	7	10
Neuroprotective Agents	7	10
Renoprotective	5	9
Cyclin D1 Down-Regulation	3	8
Anti-Tumor	2	7
Anticonvulsants	4	7
Antiparasitic Agents	4	7
MicroRNA modulator	5	6
Anti-Retroviral Agents	1	5
Gastrointestinal Agents	3	5
Tumor Suppressor Protein p53 Upregulation	5	5
Anticarcinogenic Agents	4	4
Brain-derived neurotrophic factor modulator	2	4
Cardioprotective	3	4
Interleukin-12 upregulation	2	4
Malondialdehyde Down-regulation	2	4
Osteoprotective	2	4
Anti-Ulcer Agents	2	3
Cyclooxygenase Inhibitors	2	3
Leishmanicidal	2	3
Nrf2 activation	2	3
Superoxide Dismutase Up-regulation	2	3
Vascular Endothelial Growth Factor A Inhibitor	2	3
AKT-mammalian target of rapamycin (mTOR) pathway inhibitor	1	2
Acetylcholinesterase Inhibitor	1	2
Angiogenesis Inducing Agents	1	2
Anti-Apoptotic	2	2
Anti-Cachexic Agents	1	2
Anti-HIV Agents	2	2
Autophagy Up-regulation	1	2
Cytotoxic	2	2
Hypnotics and Sedatives	1	2
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	2
Interferon Gamma Reducer	1	2
Interleukin-10 downregulation	1	2
Interleukin-10 upregulation	1	2
Interleukin-17 downregulation	1	2
Interleukin-4 downregulation	1	2
Multidrug Resistance Gene Modulators	2	2
Nitric Oxide Enhancer	1	2
P21 Activation	2	2
Radioprotective	2	2
Radiosensitizer	2	2
STAT3 Inhibitor	2	2
Survivin Down-Regulation	2	2
Vascular Endothelial Growth Factor C Inhibitor	1	2
Wnt/β-catenin signaling pathway modulation	2	2
apoptosis	1	2
Alpha-glucosidase inhibitor	1	1
Appetite Stimulants	1	1
Bcl-xL down-regulation	1	1
Heat Shock Protein Inducer	1	1
Histone deacetylase inhibitor	1	1
Interleukin-12 downregulation	1	1
Interleukin-23 Downregulation	1	1
Photoprotective	1	1
Postaglandin PGE2 downregulation	1	1
Quorum Sensing Inhibition	1	1
Reactive Oxygen Species (ROS) attenuation	1	1
Reverse Transcriptase Inhibitors	1	1

[+]

A review of the beneficial effects of antioxidants on Helicobacter pylori eradication.Nov 30, 2018

Click here to read the entire abstract

Pubmed Data : Helicobacter. 2018 Dec ;23(6):e12535. Epub 2018 Sep 6. PMID: 30191635

Article Published Date : Nov 30, 2018

Study Type : Meta Analysis, Review

Additional Links

Substances : Cranberry, Curcumin, NAC (N-acetyl-L-cysteine)

Diseases : Helicobacter Pylori Infection

Pharmacological Actions : Anti-Bacterial Agents, Antioxidants

Additional Keywords : Natural Substance/Drug Synergy

[+]

Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Des Devel Ther. 2019 ;13:1969-1984. Epub 2019 Jun 17. PMID: 31354242

Article Published Date : Dec 31, 2018

Study Type : Meta Analysis

Additional Links

Substances : Peony

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Methotrexate

[+]

Honeysuckle combined with conventional therapy may be beneficial for the treatment of COVID-19 in improving lung CT, clinical cure rate, clinical symptoms.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2021 ;12:708636. Epub 2021 Sep 15. PMID: 34603023

Article Published Date : Dec 31, 2020

Study Type : Meta Analysis, Review

Additional Links

Substances : Honeysuckle

Diseases : Coronavirus Infection

Pharmacological Actions : Antiviral Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Specific combinations of traditional medicines appeared to produce higher contributions to tumor response rate than the TMs individually.Aug 05, 2015

Click here to read the entire abstract

Pubmed Data : Integr Cancer Ther. 2015 Aug 6. Epub 2015 Aug 6. PMID: 26254190

Article Published Date : Aug 05, 2015

Study Type : Meta Analysis

Additional Links

Substances : Astragalus, Chinese Skullcap , Hedyotis corymbosa

Diseases : Colorectal Cancer

Additional Keywords : Drug: Oxaliplatin, Natural Substance/Drug Synergy

[+]

The addition of probiotics to standard therapy is associated with improved H. pylori eradication rates in both children and adults.Dec 31, 2015

Click here to read the entire abstract

Pubmed Data : Infect Drug Resist. 2016 ;9:275-289. Epub 2016 Dec 7. PMID: 27994474

Article Published Date : Dec 31, 2015

Study Type : Meta Analysis

Additional Links

Substances : Probiotics

Diseases : Diarrhea: Antibiotic-Associated, Helicobacter Pylori Infection

Pharmacological Actions : Gastroprotective

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Antibiotics

[+]

Bee products are effective in symptomatic treatment of upper respiratory tract infections.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Turk J Pediatr. 2020 ;62(4):634-640. PMID: 32779416

Article Published Date : Dec 31, 2019

Study Type : Human Study

Additional Links

Substances : Bee Products, Bee Propolis, Honey, Royal Jelly

Diseases : Upper Respiratory Infections

Pharmacological Actions : Anti-Bacterial Agents, Antiviral Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Probiotic Bifidobacterium longum supplied with methimazole improved the thyroid function of Graves' disease patients through the gut-thyroid axis Jan 06, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Commun Biol. 2021 09 7 ;4(1):1046. Epub 2021 Sep 7. PMID: 34493790

Article Published Date : Jan 06, 2021

Study Type : Human Study

Additional Links

Substances : Bifidobacterium Longum

Diseases : Graves Disease

Pharmacological Actions : Gastrointestinal Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

"Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer."Feb 28, 2011

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Lett. 2011 Mar ;2(2):319-322. Epub 2011 Jan 21. PMID: 22866084

Article Published Date : Feb 28, 2011

Study Type : Human Study

Additional Links

Substances : Fucoidan

Diseases : Colorectal Adenomas

Pharmacological Actions : Chemosensitizer

Additional Keywords : Natural Substance/Drug Synergy

[+]

Adding Berberis vulgaris fruit extract on metronidazole improve the efficacy of bacterial vaginosis therapy.Jul 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Electron Physician. 2016 Aug ;8(8):2818-2827. Epub 2016 Aug 25. PMID: 27757195

Article Published Date : Jul 31, 2016

Study Type : Human Study

Additional Links

Substances : Barberry

Diseases : Bacterial Vaginosis

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Adding M. communis extract to metronidazole increases the efficiency of bacterial vaginosis treatment.Feb 28, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Avicenna J Phytomed. 2017 Mar-Apr;7(2):129-136. PMID: 28348968

Article Published Date : Feb 28, 2017

Study Type : Human Study

Additional Links

Substances : Myrtle

Diseases : Bacterial Vaginosis

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Addition of epigallocatechin gallate 400 mg to sofosbuvir 400 mg + daclatisvir 60 mg in in treatment of patients with chronic hepatitis C.Jan 18, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2019 09 19 ;9(1):13593. Epub 2019 Sep 19. PMID: 31537880

Article Published Date : Jan 18, 2019

Study Type : Human Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Hepatitis C

Pharmacological Actions : Antiviral Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection.Nov 20, 2012

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : World J Gastroenterol. 2012 Nov 21 ;18(43):6302-7. PMID: 23180952

Article Published Date : Nov 20, 2012

Study Type : Human Study

Additional Links

Substances : Probiotics

Diseases : Helicobacter Pylori Infection

Additional Keywords : Natural Substance/Drug Synergy

[+]

Antimicrobial activity of Prunella Vulgaris extracts against multi-drug resistant Escherichia Coli from patients of urinary tract infection.Apr 30, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pak J Med Sci. 2018 May-Jun;34(3):616-620. PMID: 30034426

Article Published Date : Apr 30, 2018

Study Type : Human In Vitro, Human Study

Additional Links

Substances : Prunella vulgaris

Diseases : Escherichia coli Infections, Infection: Antibiotic Resistant, Urinary Tract Infections

Pharmacological Actions : Antimicrobial

Additional Keywords : Natural Substance/Drug Synergy

[+]

Application of Peganum harmala seed can be useful in reducing urinary symptoms in patients with benign prostatic hyperplasia.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Renal Inj Prev. 2017 ;6(2):127-131. Epub 2016 Dec 18. PMID: 28497089

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Substances : Syrian rue

Diseases : Prostatic Hyperplasia

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

Additional Keywords : Natural Substance/Drug Synergy

[+]

Black cumin seeds decreased Methotrexate hepatotoxicity and improved survival in children with ALLMar 19, 2015

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Pubmed Data : Infect Disord Drug Targets. 2015 Mar 20. Epub 2015 Mar 20. PMID: 25809628

Article Published Date : Mar 19, 2015

Study Type : Human Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Acute lymphoblastic leukemia (ALL), Drug-Induced Toxicity: Methotrexate

Pharmacological Actions : Chemotherapeutic, Hepatoprotective

Additional Keywords : Natural Substance/Drug Synergy

[+]

Cannabis users report greater pain relief in combination with opioids than when opioids are used alone.Jan 31, 2015

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Pubmed Data : Drug Alcohol Depend. 2015 Feb 1 ;147:144-50. Epub 2014 Dec 10. PMID: 25533893

Article Published Date : Jan 31, 2015

Study Type : Human Study

Additional Links

Substances : Cannabis

Diseases : Chronic Pain

Pharmacological Actions : Analgesics

Additional Keywords : Natural Substance/Drug Synergy

[+]

Clinical efficacy of acetylcysteine combined with tetrandrine tablets on patients with silicosis.Jul 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Ther Med. 2020 Aug ;20(2):1285-1290. Epub 2020 Jun 10. PMID: 32765668

Article Published Date : Jul 31, 2020

Study Type : Human Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Silicosis

Therapeutic Actions : Exercise

Additional Keywords : Natural Substance/Drug Synergy

[+]

Curcumin could reverse the development of depression and enhance the outcome of antidepressants treatment in major depressive disorder.Jul 31, 2015

Click here to read the entire abstract

Pubmed Data : J Clin Psychopharmacol. 2015 Aug ;35(4):406-10. PMID: 26066335

Article Published Date : Jul 31, 2015

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Depression

Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance/Drug Synergy, Significant Treatment Outcome

Problem Substances : Antidepressants

[+]

Curcumin may be a safe and effective therapy for maintenance of remission in quiescent UC when given as adjunctive therapy along with mesalamine or sulfasalazine. Dec 31, 2011

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cochrane Database Syst Rev. 2012 ;10:CD008424. Epub 2012 Oct 17. PMID: 23076948

Article Published Date : Dec 31, 2011

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Ulcerative Colitis

Additional Keywords : Complementary Alternative Medicine, Natural Substance/Drug Synergy, Randomized Controlled Trials As Topic

Problem Substances : Mesalamine, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Curcuminoids with piperine may be used as a safe and effective add on to standard antidepressants in patients with major depressive disorders.Dec 31, 2014

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2015 Jan ;29(1):17-21. Epub 2014 Aug 4. PMID: 25091591

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Substances : Curcumin, Piperidines

Diseases : Anxiety Disorders, Depression, Depressive Disorder

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Helicobacter pylori eradication: Sequential therapy and Lactobacillus reuteri supplementation.Nov 20, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : World J Gastroenterol. 2012 Nov 21 ;18(43):6250-4. PMID: 23180945

Article Published Date : Nov 20, 2012

Study Type : Human Study

Additional Links

Substances : Lactobacillus reuteri

Diseases : Helicobacter Pylori Infection

Additional Keywords : Natural Substance/Drug Synergy

[+]

Lavandula angustifilia infusion has some positive therapeutic effects on depressed patients most importantly decreases mean depression score and might be used alone or as an adjunct to other anti-depressant drugs.Jul 31, 2013

Click here to read the entire abstract

Pubmed Data : Iran Red Crescent Med J. 2013 Aug ;15(8):734-9. Epub 2013 Aug 5. PMID: 24578844

Article Published Date : Jul 31, 2013

Study Type : Human Study

Additional Links

Substances : Lavender

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Milled flaxseed lowers total and LDL cholesterol in patients with peripheral artery disease.Mar 31, 2015

Click here to read the entire abstract

Pubmed Data : J Nutr. 2015 Apr ;145(4):749-57. Epub 2015 Feb 18. PMID: 25694068

Article Published Date : Mar 31, 2015

Study Type : Human Study

Additional Links

Substances : Flaxseed

Diseases : Cholesterol: High, Peripheral Arterial Disease

Pharmacological Actions : Anticholesteremic Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

N-acetylcysteine combined with dexamethasone treatment improves sudden sensorineural hearing loss.Dec 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Cell Dev Biol. 2021 ;9:659486. Epub 2021 Mar 18. PMID: 33816510

Article Published Date : Dec 31, 2020

Study Type : Human Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Hearing Loss: Sudden

Pharmacological Actions : Antioxidants

Additional Keywords : Natural Substance/Drug Synergy

[+]

Preparation and optimization of garlic oil/apple vider vinegar nanoemulsion loaded with minoxidil to treat alopecia.Dec 13, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmaceutics. 2021 Dec 14 ;13(12). Epub 2021 Dec 14. PMID: 34959435

Article Published Date : Dec 13, 2021

Study Type : Human Study

Additional Links

Substances : Apple Cider Vinegar, Garlic

Diseases : Alopecia

Additional Keywords : Natural Substance/Drug Synergy

[+]

Prunella vulgaris may be a potential adjuvant medicine for breast cancer treatment.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2018 ;9:806. Epub 2018 Aug 3. PMID: 30123125

Article Published Date : Dec 31, 2017

Study Type : Human Study

Additional Links

Substances : Prunella vulgaris

Diseases : Breast Cancer

Pharmacological Actions : Chemoprotective Agents, Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Silibinin may improve the effects of methotrexate on certain biochemical and clinical markers of patients with active rheumatoid arthritis.Jun 30, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oman Med J. 2016 Jul ;31(4):263-9. PMID: 27403238

Article Published Date : Jun 30, 2016

Study Type : Human Study

Additional Links

Substances : Silibinin

Diseases : C-Reactive Protein, Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

Somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide led to an overall clinical benefit been achieved in 75% of cases.Dec 31, 2012

Click here to read the entire abstract

Pubmed Data : Neuro Endocrinol Lett. 2013 ;34(7):660-8. PMID: 24464005

Article Published Date : Dec 31, 2012

Study Type : Human Study

Additional Links

Substances : Melatonin, Vitamin D

Diseases : Breast Cancer, Breast Cancer: Metastatic, Chemotherapy-Induced Toxicity: Cyclophosphamide

Additional Keywords : Natural Substance/Drug Synergy, Significant Treatment Outcome

[+]

Synergism of allicin in combination with itraconazole and terbinafine, which could be a reference for the treatment of tinea capitis due to M. canis.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Med (Lausanne). 2021 ;8:783086. Epub 2021 Nov 26. PMID: 34901093

Article Published Date : Dec 31, 2020

Study Type : Human Study

Additional Links

Substances : Allicin

Diseases : Tinea

Pharmacological Actions : Antifungal Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

The addition of POMx to simvastatin therapy in hypercholesterolemic patients improved oxidative stress and lipid status in the patient's serum and in their HMDM. Dec 31, 2013

Click here to read the entire abstract

Pubmed Data : Atherosclerosis. 2014 Jan ;232(1):204-10. Epub 2013 Nov 19. PMID: 24401239

Article Published Date : Dec 31, 2013

Study Type : Human Study

Additional Links

Substances : Pomegranate

Diseases : Atherosclerosis, High Cholesterol, Oxidative Stress, Triglycerides: Elevated

Pharmacological Actions : Anti-atherogenic, Antioxidants, Hypolipidemic

Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts

Problem Substances : Simvastatin, Statin Drugs

[+]

The administration of soybean could enhance the response to SSRI anti depressants in menopausal women.Feb 28, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Acta Pol Pharm. 2014 Mar-Apr;71(2):323-7. PMID: 25272653

Article Published Date : Feb 28, 2014

Study Type : Human Study

Additional Links

Substances : Soy

Diseases : Depression, Depression: Postmenopausal

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Fluoxetine (trade name Prozac) , Sertraline

[+]

The administration of soybean could enhance the response to SSRI anti depressants in menopausal women.Feb 28, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Acta Pol Pharm. 2014 Mar-Apr;71(2):323-7. PMID: 25272653

Article Published Date : Feb 28, 2014

Study Type : Human Study

Additional Links

Substances : Soy

Diseases : Depression, Depression: Postmenopausal

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Fluoxetine (trade name Prozac) , Sertraline

[+]

The combination of bevacizumab and tocotrienol is potent in chemotherapy refractory ovarian cancer. Feb 28, 2019

Click here to read the entire abstract

Pubmed Data : Pharmacol Res. 2019 Mar ;141:392-396. Epub 2019 Jan 9. PMID: 30639384

Article Published Date : Feb 28, 2019

Study Type : Human Study

Additional Links

Substances : Tocotrienol: Delta

Diseases : Ovarian Cancer

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

[+]

The combination of serenoa repens, selenium, lycopene and bromelain are beneficial in patients with chronic bacterial prostatitis.Oct 04, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Arch Ital Urol Androl. 2016 Oct 5 ;88(3):177-182. Epub 2016 Oct 5. PMID: 27711089

Article Published Date : Oct 04, 2016

Study Type : Human Study

Additional Links

Substances : Bromelain, Lycopene, Saw Palmetto, Selenium

Diseases : Prostatitis: Bacterial

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts

[+]

The combined use of echinacea with azithromycin produced favourable outcome than azithromycin alone in pediatric patients with recurrent tonsillitis.Jul 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Otolaryngol. 2020 Jul - Aug;41(4):102344. Epub 2019 Nov 12. PMID: 32487336

Article Published Date : Jul 31, 2020

Study Type : Human Study

Additional Links

Substances : Echinacea

Diseases : Tonsillitis

Additional Keywords : Natural Substance/Drug Synergy

[+]

The potential prebiotic berberine combined with methimazole improved the therapeutic effect of Graves' disease patients.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Immunol. 2021 ;12:826067. Epub 2022 Jan 10. PMID: 35082799

Article Published Date : Dec 31, 2020

Study Type : Human Study

Additional Links

Substances : Berberine

Diseases : Graves Disease

Pharmacological Actions : Gastrointestinal Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

6-shogaol, 6-gingerol and pterostilbene selectively killed breast cancer stem cells.Mar 10, 2015

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2015 Mar 11 ;63(9):2432-41. Epub 2015 Feb 25. PMID: 25686711

Article Published Date : Mar 10, 2015

Study Type : Human In Vitro

Additional Links

Substances : 6-Shogaol, Gingerol , Pterostilbene

Diseases : Breast Cancer, Breast Cancer Stem Cells

Pharmacological Actions : Chemosensitizer, Cyclin D1 Down-Regulation

Additional Keywords : Natural Substance/Drug Synergy

[+]

Amurensin G. was a potent SIRT1 Inhibitor which led to the down regulation of multidrug resistance.Oct 31, 2010

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Pharmacol. 2010 Nov ;78(5):855-64. Epub 2010 Aug 16. PMID: 20713551

Article Published Date : Oct 31, 2010

Study Type : Animal Study, Human In Vitro

Additional Links

Substances : Amurensin G

Diseases : Breast Cancer: Drug Resistant, Cancers: Drug Resistant

Pharmacological Actions : Chemosensitizer

Additional Keywords : Gene Expression Regulation, Natural Substance/Drug Synergy, Plant Extracts

Problem Substances : Doxorubicin

[+]

Combinations of EGCG and anticancer compounds induced synergistic anticancer effects in vitro and in vivo experiments, and showed an average reduction in tumor volume by 70.3 %.Aug 31, 2015

Click here to read the entire abstract

Pubmed Data : J Cancer Res Clin Oncol. 2015 Sep ;141(9):1511-22. Epub 2014 Dec 28. PMID: 25544670

Article Published Date : Aug 31, 2015

Study Type : Animal Study, Human In Vitro

Additional Links

Substances : Catechin , EGCG (Epigallocatechin gallate), Green Tea

Diseases : Cancers: All

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Cancer Stem Cells, Natural Substance/Drug Synergy

[+]

Findings suggest that Plantago ovata husk could be a potentially useful adjuvant in chemotherapy for colorectal cancer.Jun 01, 2012

Click here to read the entire abstract

Pubmed Data : Br J Nutr. 2012 Jun ;107(11):1591-602. Epub 2011 Sep 29. PMID: 22018732

Article Published Date : Jun 01, 2012

Study Type : Human In Vitro

Additional Links

Substances : Plantago major

Diseases : Colorectal Cancer

Additional Keywords : Natural Substance/Drug Synergy

[+]

Hydrocortisone and ascorbic acid synergistically prevent and repair lipopolysaccharide-induced pulmonary endothelial barrier dysfunction.Jan 10, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Chest. 2017 11 ;152(5):954-962. Epub 2017 Jul 21. PMID: 28739448

Article Published Date : Jan 10, 2017

Study Type : Human In Vitro

Additional Links

Substances : Vitamin C

Diseases : Endothelial Dysfunction, Lipopolysaccharide-Induced Toxicity, Sepsis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

Additional Keywords : Natural Substance/Drug Synergy

[+]

Piperine enhanced mitomycin-C therapy in human cervical cancer cells.Nov 19, 2017

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2017 Nov 20. Epub 2017 Nov 20. PMID: 29169726

Article Published Date : Nov 19, 2017

Study Type : Human In Vitro

Additional Links

Substances : Piperine

Diseases : Cervical Cancer

Pharmacological Actions : Bcl-2 protein down-regulation, Chemosensitizer

Additional Keywords : Natural Substance/Drug Synergy

[+]

Prunella vulgaris has potent anti-Ebola virus activity and may be developed as a novel antiviral approach against EBOV infection.Feb 29, 2016

Click here to read the entire abstract

Pubmed Data : Antiviral Res. 2016 Mar ;127:20-31. Epub 2016 Jan 9. PMID: 26778707

Article Published Date : Feb 29, 2016

Study Type : Human In Vitro

Additional Links

Substances : Prunella vulgaris

Diseases : Ebola Virus Infections

Pharmacological Actions : Anti-Retroviral Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Pterostilbene might be used to modulate two anticancer compounds in well-defined sets of GBM patients.Nov 07, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2016 Nov 8 ;7(45):73200-73215. PMID: 27689322

Article Published Date : Nov 07, 2016

Study Type : Human In Vitro

Additional Links

Substances : Pterostilbene

Diseases : Glioblastoma Multiforme

Pharmacological Actions : Antiproliferative , Cell cycle arrest, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Gefitinib, Natural Substance/Drug Synergy

[+]

The combination of centchroman with genistein has selective cytotoxic effect for human breast cancer cell lines.Oct 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Indian J Pharmacol. 2016 Nov-Dec;48(6):637-642. PMID: 28066099

Article Published Date : Oct 31, 2016

Study Type : Human In Vitro

Additional Links

Substances : Genistein

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Chemosensitizer

Additional Keywords : Breast Cancer, Breast Cancer: Triple Negative, Chemosensitizer, Genistein, Natural Substance/Drug Synergy, Selective Cytotoxicity

[+]

These results suggest deguelin could have potential for the treatment of human CLL.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2016 ;11(4):e0154159. Epub 2016 Apr 21. PMID: 27101369

Article Published Date : Dec 31, 2015

Study Type : Animal Study, Human In Vitro

Additional Links

Substances : Deguelin

Diseases : Chronic Lymphocytic Leukemia

Pharmacological Actions : Apoptotic, NF-kappaB Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

Beetroot-carrot juice can be used as an effective treatment for CLL alone or in combination with chlorambucil.Jun 14, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Open Access Maced J Med Sci. 2015 Jun 15 ;3(2):331-6. Epub 2015 Jun 2. PMID: 27275246

Article Published Date : Jun 14, 2015

Study Type : Human: Case Report

Additional Links

Substances : Beet, Carrot

Diseases : Leukemia: Chronic Lymphocytic Leukemia (CLL)

Pharmacological Actions : Chemopreventive, Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Omalizumab ensures compatibility to bee venom immunotherapy (VIT) after VIT-induced anaphylaxis in a patient with systemic mastocytosis.Dec 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Allergol Select. 2021 ;5:128-132. Epub 2021 Mar 11. PMID: 33733040

Article Published Date : Dec 31, 2020

Study Type : Human: Case Report

Additional Links

Substances : Bee Venom

Diseases : Mastocytosis

Additional Keywords : Natural Substance/Drug Synergy

[+]

Synergistic effect of oridonin and a PI3K/mTOR inhibitor on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma.Jan 22, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Hematol Oncol. 2016 08 23 ;9(1):72. Epub 2016 Aug 23. PMID: 27554093

Article Published Date : Jan 22, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Oridonin

Diseases : Lymphoma: B-Cell

Pharmacological Actions : Apoptotic

Additional Keywords : Natural Substance/Drug Synergy

[+]

The combination of Biochanin A and SB590885 potentiates the inhibition of tumour progression in hepatocellular carcinoma.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Cell Int. 2020 ;20:371. Epub 2020 Aug 5. PMID: 32774165

Article Published Date : Dec 31, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Biochanin A

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Natural Substance/Drug Synergy

[+]

The dual roles of ginsenosides in improving the anti-tumor efficiency of cyclophosphamide in mammary carcinoma mice. Aug 23, 2020

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2020 Aug 24:113271. Epub 2020 Aug 24. PMID: 32853742

Article Published Date : Aug 23, 2020

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Breast Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemotherapeutic, Nrf2 activation

Additional Keywords : Natural Substance/Drug Synergy

[+]

A combination of ascorbate with Amphotericin B is a potentially effective treatment that may reduce nephrotoxicity in patients with systemic candidiasis.Jul 31, 2015

Click here to read the entire abstract

Pubmed Data : Am J Physiol Regul Integr Comp Physiol. 2015 Aug 1 ;309(3):R223-34. PMID: 25994956

Article Published Date : Jul 31, 2015

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Candida Albicans, Candidiasis, Sepsis

Pharmacological Actions : Renoprotective

Additional Keywords : Natural Substance/Drug Synergy

[+]

Achillea fragrantissima, rich in flavonoids and tannins, potentiates the activity of diminazine aceturate against Trypanosoma evansi in rats.Feb 29, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Trop Med. 2016 Mar ;9(3):228-34. Epub 2016 Jan 11. PMID: 26972392

Article Published Date : Feb 29, 2016

Study Type : Animal Study

Additional Links

Substances : Achillea fragrantissima

Diseases : Parasitic Diseases

Pharmacological Actions : Antiparasitic Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Additive antiangiogenesis effect of ginsenoside Rg3 with low-dose metronomic temozolomide on rat glioma cells both in vivo and in vitro.Feb 12, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Exp Clin Cancer Res. 2016 Feb 13 ;35:32. Epub 2016 Feb 13. PMID: 26872471

Article Published Date : Feb 12, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Glioblastoma

Pharmacological Actions : Anti-Angiogenic, Antiproliferative , Cell cycle arrest

Additional Keywords : Natural Substance/Drug Synergy

[+]

AGE showed synergistic effects with NTX on inhibition of tumor growth and increment of survival times.Jun 30, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacognosy Res. 2013 Jul ;5(3):189-94. PMID: 23901215

Article Published Date : Jun 30, 2013

Study Type : Animal Study

Additional Links

Substances : Garlic: Aged

Diseases : Fibrosarcoma

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Antiproliferative , Chemopreventive

Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts

[+]

Alleviation of fructose-induced Alzheimer's disease in rats by pioglitazone and decaffeinated green coffee bean extract.Apr 30, 2021

Click here to read the entire abstract

Pubmed Data : J Food Biochem. 2021 May ;45(5):e13715. Epub 2021 Mar 29. PMID: 33782984

Article Published Date : Apr 30, 2021

Study Type : Animal Study

Additional Links

Substances : Green Coffee Bean

Diseases : Alzheimer's Disease, High Fructose Diet

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Alpha-tocopherol attenuates the anti-tumor activity of crizotinib against cells transformed by NPM-ALK.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2017 ;12(8):e0183003. Epub 2017 Aug 14. PMID: 28806414

Article Published Date : Dec 31, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Vitamin E: alpha tocopherol

Pharmacological Actions : Antineoplastic Agents, Apoptotic

Additional Keywords : Natural Substance/Drug Synergy

[+]

An extract of Allspice was shown to be effective in decreasing the growth of MB231 tumors by oral administration, and this effect was greater when pretreated with AAE as a chemo-preventive agent.Apr 13, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2015 Apr 14. Epub 2015 Apr 14. PMID: 25945840

Article Published Date : Apr 13, 2015

Study Type : Animal Study

Additional Links

Substances : Allspice

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : AKT-mammalian target of rapamycin (mTOR) pathway inhibitor, Apoptotic, Autophagy Up-regulation, Chemopreventive

Additional Keywords : Dietary Concentrations, Drug: Rapamycin, Natural Substance/Drug Synergy

[+]

Anthocyanins work in synergy with trastuzumab by induced apoptosis, inhibited cell growth and affected HER2 downstream signaling.Sep 30, 2014

Click here to read the entire abstract

Pubmed Data : Mol Med Rep. 2014 Oct ;10(4):1921-6. Epub 2014 Jul 22. PMID: 25070704

Article Published Date : Sep 30, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Anthocyanins, Cyanidin 3-glucoside

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Anti-Tumor, Antiproliferative , apoptosis

Additional Keywords : Drug: Trastuzumab, Natural Substance/Drug Synergy, Supplements

[+]

Anti-tumor activity of tanshinone IIA in combined with cyclophosphamide against Lewis mice with lung cancer.Jan 10, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Trop Med. 2016 11 ;9(11):1084-1088. Epub 2016 Oct 22. PMID: 27890369

Article Published Date : Jan 10, 2016

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Lung Cancer

Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Anticancer effects of combination of indole-3-carbinol and hydroxychloroquine on ehrlich ascites carcinoma.Aug 10, 2021

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2021 Aug 11:1-17. Epub 2021 Aug 11. PMID: 34379013

Article Published Date : Aug 10, 2021

Study Type : Animal Study

Additional Links

Substances : Indole-3-Carbinol

Diseases : Ehrlich carcinoma

Pharmacological Actions : Apoptotic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Antinociceptive synergy between metamizole and hesperidin. Jan 18, 2021

Click here to read the entire abstract

Pubmed Data : Arch Med Res. 2021 Jan 19. Epub 2021 Jan 19. PMID: 33483148

Article Published Date : Jan 18, 2021

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Chronic Pain

Pharmacological Actions : Antinoceceptive

Additional Keywords : Natural Substance/Drug Synergy

[+]

Ascorbic acid protects against the nephrotoxicity and apoptosis caused by colistin and affects its pharmacokinetics.Jan 31, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Antimicrob Chemother. 2012 Feb ;67(2):452-9. Epub 2011 Nov 28. PMID: 22127588

Article Published Date : Jan 31, 2012

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Renoprotective

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Antibiotics

[+]

Aspalathin from rooibos improves the hypoglycemic potential of metformin in type 2 diabetic mice.Nov 13, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Physiol Res. 2018 Nov 14 ;67(5):813-818. Epub 2018 Jul 25. PMID: 30044119

Article Published Date : Nov 13, 2018

Study Type : Animal Study

Additional Links

Substances : Rooibos

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Hypoglycemic Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Baicalein enhances the effect of acarbose on the improvement of nonalcoholic fatty liver disease associated with prediabetes.Aug 31, 2021

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2021 Sep 1 ;69(34):9822-9836. Epub 2021 Aug 18. PMID: 34406004

Article Published Date : Aug 31, 2021

Study Type : Animal Study

Additional Links

Substances : Baicalein

Diseases : Nonalcoholic fatty liver disease (NAFLD), Prediabetes

Pharmacological Actions : Hepatoprotective

Additional Keywords : Natural Substance/Drug Synergy

[+]

Berberine might be a promising synergist to enhance the antimicrobial activity of azithromycin in vitro and in vivo.Jul 23, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell Physiol Biochem. 2017 Jul 24 ;42(4):1657-1669. Epub 2017 Jul 24. PMID: 28738346

Article Published Date : Jul 23, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : Pseudomonas aeruginosa

Pharmacological Actions : Antimicrobial

Additional Keywords : Natural Substance/Drug Synergy

[+]

Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells.Apr 18, 2004

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Br J Cancer. 2004 Apr 19 ;90(8):1672-8. PMID: 15083202

Article Published Date : Apr 18, 2004

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Betulinic acid

Diseases : Cancer Metastasis, Melanoma, Skin Cancer

Pharmacological Actions : Anti-metastatic, Chemosensitizer

Additional Keywords : Natural Substance/Drug Synergy

[+]

Calcitriol enhanced the efficacy of irinotecan in growth inhibition and apoptosis induction.Jul 24, 2016

Click here to read the entire abstract

Pubmed Data : Mol Cancer Ther. 2016 Jul 25. Epub 2016 Jul 25. PMID: 27458137

Article Published Date : Jul 24, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Vitamin D

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Chrysanthemum indicum could enhance the anti-cancer activity of bleomycin and reduce the its induced pulmonary injury in H22 tumor-bearing mice.Feb 23, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2017 Feb 24 ;18(3). Epub 2017 Feb 24. PMID: 28245556

Article Published Date : Feb 23, 2017

Study Type : Animal Study

Additional Links

Substances : Chrysanthemum Indicum

Diseases : Chemotherapy-Induced Toxicity: Bleomycin

Pharmacological Actions : Chemoprotective Agents, Chemosensitizer

Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts

[+]

Chrysin strengthened the therapeutic efficacy of docetaxel and diminished the adverse effect of it.May 04, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Integr Cancer Ther. 2016 May 5. Epub 2016 May 5. PMID: 27151585

Article Published Date : May 04, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Chrysin

Diseases : Carcinoma: Non-Small-Cell Lung, Chemotherapy and Radiation Toxicity, Gastric Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemoprotective Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Cinnamaldehyde enhances antimelanoma activity through covalently binding ENO1 and exhibits a promoting effect with dacarbazine.Jan 28, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancers (Basel). 2020 Jan 29 ;12(2). Epub 2020 Jan 29. PMID: 32013122

Article Published Date : Jan 28, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cinnamaldehyde

Diseases : Melanoma

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Co-administration of carrot fruit significantly enhanced both ulcer preventive effects and ulcer healing properties of the pantoprazole.Nov 12, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2020 Nov 13 ;25(22). Epub 2020 Nov 13. PMID: 33202703

Article Published Date : Nov 12, 2020

Study Type : Animal Study

Additional Links

Substances : Carrot

Diseases : Gastric Ulcer

Pharmacological Actions : Anti-Ulcer Agents, Gastroprotective

Additional Keywords : Natural Substance/Drug Synergy

[+]

Co-administration of EGb 761 and donepezil exerted better anti-amnestic effect.Dec 24, 2020

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2020 Dec 25 ;269:113711. Epub 2020 Dec 25. PMID: 33352242

Article Published Date : Dec 24, 2020

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Co-administration of hyperforin and lanicemine induces long-lasting antidepressant effects.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Mol Neurosci. 2018 ;11:456. Epub 2018 Dec 12. PMID: 30618608

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Hyperforin

Diseases : Depression

Pharmacological Actions : Antidepressive Agents, Brain-derived neurotrophic factor modulator

Additional Keywords : Natural Substance/Drug Synergy

[+]

Co-delivery of deferoxamine and hydroxysafflor yellow A to accelerate diabetic wound healing via enhanced angiogenesis.Oct 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Deliv. 2018 Nov ;25(1):1779-1789. PMID: 30338719

Article Published Date : Oct 31, 2018

Study Type : Animal Study

Additional Links

Substances : Safflower

Diseases : Wound Healing

Pharmacological Actions : Angiogenesis Inducing Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Combination effects of metformin and a mixture of lemon balm and dandelion on high-fat diet-induced metabolic alterations.Mar 17, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antioxidants (Basel). 2022 Mar 18 ;11(3). Epub 2022 Mar 18. PMID: 35326230

Article Published Date : Mar 17, 2022

Study Type : Animal Study

Additional Links

Substances : Dandelion , Lemon Balm

Diseases : High Fat Diet, Insulin Resistance, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective

Additional Keywords : Natural Substance/Drug Synergy

[+]

Combination of berberine with pentoxifylline illustrated a synergistic effect in attenuation of diclofenac-induced acute kidney injury.Mar 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Crit Illn Inj Sci. 2019 Apr-Jun;9(2):69-74. PMID: 31334048

Article Published Date : Mar 31, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Kidney Damage: Drug-Induced

Pharmacological Actions : Renoprotective

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Diclofenac

[+]

Combination of curcumin and mitomycin C can synergistically inhibit tumor growth in MCF-7 breast cancer xenografts and induce apoptosis in breast cancer MCF-7 cells.Dec 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2014 ;15(9):16284-301. Epub 2014 Sep 15. PMID: 25226537

Article Published Date : Dec 31, 2013

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Breast Cancer

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemotherapeutic

Additional Keywords : Drug: Mitomycin, Natural Substance/Drug Synergy

[+]

Combination of erythromycin and curcumin alleviates Staphylococcus aureus induced osteomyelitis.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Cell Infect Microbiol. 2017 ;7:379. Epub 2017 Aug 24. PMID: 28884090

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Osteomyelitis, Staphylococcus aureus: Methicillin-resistant (MRSA)

Pharmacological Actions : Anti-Bacterial Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

Combination of Ocimum sanctum extract and Levetiracetam ameliorates cognitive dysfunction and hippocampal architecture in rat model of Alzheimer's disease.Dec 31, 2021

Click here to read the entire abstract

Pubmed Data : J Chem Neuroanat. 2022 03 ;120:102069. Epub 2021 Dec 29. PMID: 34973350

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Holy Basil

Diseases : Alzheimer's Disease, Neurodegenerative Diseases

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts

[+]

Combination of Panax notoginseng saponins and aspirin potentiates platelet inhibition with alleviated gastric injury.Dec 24, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2020 Dec 25 ;134:111165. Epub 2020 Dec 25. PMID: 33370633

Article Published Date : Dec 24, 2020

Study Type : Animal Study

Additional Links

Substances : Panax Notoginseng

Diseases : Aspirin-Induced Toxicity

Pharmacological Actions : Gastroprotective

Additional Keywords : Natural Substance/Drug Synergy

[+]

Combination of Rheum ribes and metformin against diabetes, thermal hyperalgesia, and tactile allodynia.Aug 31, 2018

Click here to read the entire abstract

Pubmed Data : Altern Ther Health Med. 2018 Sep ;24(5):33-43. PMID: 28987074

Article Published Date : Aug 31, 2018

Study Type : Animal Study

Additional Links

Substances : Rhubarb

Diseases : Allodynia, Hyperalgesia

Pharmacological Actions : Antinoceceptive , Antioxidants, Hypoglycemic Agents

Additional Keywords : Natural Substance/Drug Synergy, Phytotherapy, Plant Extracts

[+]

Combinational treatment effect of tetrahydrocurcumin and celecoxib on cervical cancer cell-induced tumor growth and tumor angiogenesis.Jun 30, 2016

Click here to read the entire abstract

Pubmed Data : J Med Assoc Thai. 2016 Jul ;99 Suppl 4:S23-31. PMID: 29916670

Article Published Date : Jun 30, 2016

Study Type : Animal Study

Additional Links

Substances : Curcumin, Tetrahydrocurcumin

Diseases : Cervical Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Angiogenic, Apoptotic, Cyclooxygenase 2 Inhibitors

Additional Keywords : Natural Substance/Drug Synergy

[+]

Combinations of nobiletin with paclitaxel and carboplatin significantly suppressed the growth of subcutaneous A549 tumors xenografts in nude mice.Mar 31, 2014

Click here to read the entire abstract

Pubmed Data : Planta Med. 2014 Apr ;80(6):452-7. Epub 2014 Mar 31. PMID: 24687742

Article Published Date : Mar 31, 2014

Study Type : Animal Study

Additional Links

Substances : Nobiletin

Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Drug: Carboplatin, Natural Substance/Drug Synergy, Plant Extracts

[+]

Combined treatment of curcumin with low doses of prednisolone may find therapeutic use in arthritis.Dec 31, 2013

Click here to read the entire abstract

Pubmed Data : J Pharm Pharmacol. 2014 Jan ;66(1):133-44. Epub 2013 Oct 21. PMID: 24138213

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts

[+]

Combing sinomenine and gabapentin or ligustrazine hydrochloride could be highly beneficial in neuropathic pain therapies.Jul 04, 2019

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2019 Jul 5 ;854:101-108. Epub 2019 Apr 4. PMID: 30954565

Article Published Date : Jul 04, 2019

Study Type : Animal Study

Additional Links

Substances : Sinomenine

Diseases : Neuropathic Pain, Sciatica, Spinal Cord Injuries

Pharmacological Actions : Analgesics

Additional Keywords : Natural Substance/Drug Synergy

[+]

Corn silk polysaccharides have potent inhibitory effects on implanted H22 tumors.Sep 30, 2014

Click here to read the entire abstract

Pubmed Data : Zhong Yao Cai. 2014 Oct ;37(10):1833-6. PMID: 25895394

Article Published Date : Sep 30, 2014

Study Type : Animal Study

Additional Links

Substances : Corn Silk

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Liver Cancer

Pharmacological Actions : Chemoprotective Agents

Additional Keywords : Chemotherapeutic Agent: Cyclophosphamide, Natural Substance/Drug Synergy, Polysaccharides

[+]

Curcumin combined with metformin may act synergistically on dyslipidemia and oxidative stress, as well as increased PON 1 levels.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Diabetol Metab Syndr. 2019 ;11:33. Epub 2019 Apr 30. PMID: 31061679

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Dyslipidemias, Hyperglycemia

Pharmacological Actions : Antioxidants, Hypoglycemic Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Curcumin enhances the activity of fluconazole against Cryptococcus gattii-induced cryptococcosis infection in mice.Oct 06, 2015

Click here to read the entire abstract

Pubmed Data : J Appl Microbiol. 2015 Oct 7. Epub 2015 Oct 7. PMID: 26442997

Article Published Date : Oct 06, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cryptococcosis

Pharmacological Actions : Antifungal Agents

Additional Keywords : Drug: Fluconazole, Natural Substance/Drug Synergy

[+]

Curcumin sensitizes human colorectal cancer to capecitabine.Oct 31, 2009

Click here to read the entire abstract

Pubmed Data : Int J Cancer. 2009 Nov 1 ;125(9):2187-97. PMID: 19623659

Article Published Date : Oct 31, 2009

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

Dandelion and lemongrass extracts were able to significantly reduce the tumour burden in prostate cancer xenograft models.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:2951428. Epub 2019 Jul 17. PMID: 31391857

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Dandelion , Lemongrass

Diseases : Prostate Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Natural Substance/Drug Synergy, Selective Cytotoxicity

[+]

Distinct interactions of cannabidiol and morphine in three nociceptive behavioral models in mice.Mar 31, 2015

Click here to read the entire abstract

Pubmed Data : Behav Pharmacol. 2015 Apr ;26(3):304-14. PMID: 25485642

Article Published Date : Mar 31, 2015

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Additional Keywords : Natural Substance/Drug Synergy

[+]

Effects of probiotics on pentylenetetrazol-induced convulsions.Jan 09, 2021

Click here to read the entire abstract

Pubmed Data : Epilepsy Res. 2021 10 ;176:106723. Epub 2021 Jul 12. PMID: 34304017

Article Published Date : Jan 09, 2021

Study Type : Animal Study

Additional Links

Substances : Probiotics

Diseases : Seizures

Pharmacological Actions : Anticonvulsants, Gastrointestinal Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Ellagic acid enhances morphine analgesia and attenuates the development of morphine tolerance and dependence.Oct 14, 2014

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2014 Oct 15 ;741:272-80. Epub 2014 Aug 30. PMID: 25179576

Article Published Date : Oct 14, 2014

Study Type : Animal Study

Additional Links

Substances : Ellagic Acid

Diseases : Morphine Tolerance/Dependence

Additional Keywords : Natural Substance/Drug Synergy

[+]

Embelin protects against acute pentylenetetrazole-induced seizures and positively modulates cognitive function.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2019 ;10:1249. Epub 2019 Oct 25. PMID: 31708779

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : False Black Pepper

Diseases : Seizures: Drug-Induced

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Endostar combined with ginsenoside Rg3 has stronger inhibiting effect on breast cancer tumor growth in tumor-bearing mice than single drug.Jan 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Trop Med. 2016 Feb ;9(2):180-3. Epub 2016 Jan 11. PMID: 26919952

Article Published Date : Jan 31, 2016

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Breast Cancer

Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor A Inhibitor, Vascular Endothelial Growth Factor C Inhibitor, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Natural Substance/Drug Synergy

[+]

Evening primrose oil significantly reduced the synovial hyperplasia and inflammatory cells invasion in joint tissues.Sep 30, 2014

Click here to read the entire abstract

Pubmed Data : Inflammopharmacology. 2014 Oct ;22(5):305-17. Epub 2014 Mar 25. PMID: 24664592

Article Published Date : Sep 30, 2014

Study Type : Animal Study

Additional Links

Substances : Evening Primrose Oil

Diseases : Arthritis, Inflammation, Lipid Peroxidation, Oxidative Stress, Rheumatoid Arthritis

Pharmacological Actions : Anti-Angiogenic, Anti-Inflammatory Agents, Antioxidants, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine.Apr 14, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Clin Cancer Res. 2012 Apr 15 ;18(8):2220-9. Epub 2012 Feb 20. PMID: 22351692

Article Published Date : Apr 14, 2012

Study Type : Animal Study

Additional Links

Substances : Tocotrienol: Gamma, Vitamin E

Diseases : Gastric Cancer

Pharmacological Actions : Anti-metastatic, Bcl-2 protein down-regulation, Chemosensitizer, Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

Flos Lonicera and metformin in combination exerts a synergistic effect on the improvement of hepatosteatosis and insulin sensitivity.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Microbiol. 2017 ;8:2271. Epub 2017 Nov 17. PMID: 29204141

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Honeysuckle

Diseases : Diabetes Mellitus: Type 2, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Gastrointestinal Agents, Hepatoprotective, Hypoglycemic Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Gallic acid potentiate the antihyperglycemic effect of acarbose and metformin.Jan 23, 2020

Click here to read the entire abstract

Pubmed Data : Arch Physiol Biochem. 2020 Jan 24:1-9. Epub 2020 Jan 24. PMID: 31979987

Article Published Date : Jan 23, 2020

Study Type : Animal Study

Additional Links

Substances : Gallic Acid

Diseases : Hyperglycemia

Pharmacological Actions : Hypoglycemic Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Genipin enhances the antitumor effect of elesclomol in A549 lung cancer cells.Nov 30, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Lett. 2020 Dec ;20(6):374. Epub 2020 Oct 21. PMID: 33154772

Article Published Date : Nov 30, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Genipin

Diseases : Lung Cancer

Pharmacological Actions : Chemosensitizer

Additional Keywords : Natural Substance/Drug Synergy

[+]

Gentamicin in combination with ascorbic acid regulates the severity of Staphylococcus aureus infection-induced septic arthritis in mice.Nov 30, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Scand J Immunol. 2012 Dec ;76(6):528-40. PMID: 22924656

Article Published Date : Nov 30, 2012

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Oxidative Stress, Staphylococcus aureus infection

Pharmacological Actions : Antioxidants, Interferon Gamma Reducer, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Antioxidants, Natural Substance/Drug Synergy, oxidative stress, Staphylococcus aureus infection, Vitamin C

[+]

Ginsenoside 20(S)-Rh2 enhanced the antibacterial effects of ciprofloxacin in vitro and in vivo.Oct 04, 2014

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2014 Oct 5 ;740:277-84. Epub 2014 Jul 20. PMID: 25054686

Article Published Date : Oct 04, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Staphylococcus aureus infection

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Ginsenoside Rg3 significantly inhibited growth and angiogenesis of ovarian cancer when used alone or combined with cyclophosphamide.Apr 04, 2007

Click here to read the entire abstract

Pubmed Data : Chin Med J (Engl). 2007 Apr 5 ;120(7):584-8. PMID: 17442207

Article Published Date : Apr 04, 2007

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Ovarian Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Natural Substance/Drug Synergy

[+]

Glioma progression is suppressed by Naringenin and APO2L combination therapy.Aug 06, 2020

Click here to read the entire abstract

Pubmed Data : Invest New Drugs. 2020 Aug 7. Epub 2020 Aug 7. PMID: 32767162

Article Published Date : Aug 06, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Naringenin

Diseases : Glioma

Pharmacological Actions : Apoptotic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Green tea extract synergistically enhances the effectiveness of an antiresorptive drug on management of osteoporosis.Mar 31, 2021

Click here to read the entire abstract

Pubmed Data : Exp Ther Med. 2021 Apr ;21(4):328. Epub 2021 Feb 5. PMID: 33732301

Article Published Date : Mar 31, 2021

Study Type : Animal Study

Additional Links

Substances : Green Tea

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

Additional Keywords : Natural Substance/Drug Synergy

[+]

H. procumbens cooperates synergistically with morphine in resolving hyperalgesia and allodynia.May 31, 2016

Click here to read the entire abstract

Pubmed Data : Nat Prod Res. 2016 Jun ;30(11):1248-55. Epub 2015 Jul 20. PMID: 26189616

Article Published Date : May 31, 2016

Study Type : Animal Study

Additional Links

Substances : Devils Claw

Diseases : Allodynia, Hyperalgesia, Neuropathic Pain

Additional Keywords : Natural Substance/Drug Synergy

[+]

High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model.Jan 06, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Proc Natl Acad Sci U S A. 2020 Jan 7. Epub 2020 Jan 7. PMID: 31911474

Article Published Date : Jan 06, 2020

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Lymphoma: B-Cell

Pharmacological Actions : Chemotherapeutic, Immunomodulatory

Additional Keywords : Natural Substance/Drug Synergy

[+]

HU-331 was more active on cancer growth and less toxic for the tumor-bearing host than doxorubicin.Jul 31, 2007

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Pharmacol Exp Ther. 2007 Aug ;322(2):646-53. Epub 2007 May 3. PMID: 17478614

Article Published Date : Jul 31, 2007

Study Type : Animal Study

Additional Links

Substances : Cannabinoids: Synthetic

Diseases : Cancers: All, Lipid Peroxidation

Pharmacological Actions : Antineoplastic Agents, Malondialdehyde Down-regulation

Additional Keywords : Natural Substance/Drug Synergy

[+]

Hydrogen sulfide inhibits inflammatory pain and enhances the analgesic properties of delta opioid receptors.Dec 10, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antioxidants (Basel). 2021 Dec 11 ;10(12). Epub 2021 Dec 11. PMID: 34943080

Article Published Date : Dec 10, 2021

Study Type : Animal Study

Additional Links

Substances : Organosulfur Compounds

Diseases : Chronic Pain, Inflammation

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Antioxidants, Nrf2 activation

Additional Keywords : Natural Substance/Drug Synergy

[+]

L-Carnitine potentiates the anti-inflammatory and antinociceptive effects of diclofenac sodium.Jul 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Basic Med Sci. 2020 Aug ;23(8):1035-1044. PMID: 32952950

Article Published Date : Jul 31, 2020

Study Type : Animal Study

Additional Links

Substances : L-Carnitine

Diseases : Inflammation, Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Diclofenac

[+]

Lactobacillus rhamnosus R0011 treatment enhanced efficacy of capecitabine against colon cancer.Dec 16, 2021

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2021 Dec 17:1-10. Epub 2021 Dec 17. PMID: 34918611

Article Published Date : Dec 16, 2021

Study Type : Animal Study

Additional Links

Substances : Lactobacillus rhamnosus

Diseases : Colon Cancer

Pharmacological Actions : Chemosensitizer

Additional Keywords : Natural Substance/Drug Synergy

[+]

Lactoferrin modified daunorubicin plus honokiol liposomes could be used as a potential therapy for treatment of brain glioma.Jun 02, 2017

Click here to read the entire abstract

Pubmed Data : Eur J Pharm Sci. 2017 Jun 3 ;106:185-197. Epub 2017 Jun 3. PMID: 28583810

Article Published Date : Jun 02, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Honokiol

Diseases : Glioma

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Drug: Daunorubicin, Natural Substance/Drug Synergy

[+]

Luteolin could restore sensitivity of oxaliplatin resistant cell lines to chemotherapeutic drugs.Dec 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Cancer Prev. 2014 ;15(6):2911-6. PMID: 24761924

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Luteolin

Diseases : Cancers: Drug Resistant, Colorectal Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Drug: Oxaliplatin, Natural Substance/Drug Synergy

[+]

Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cells.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Cell Int. 2019 ;19:68. Epub 2019 Mar 21. PMID: 30948928

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Lycopene

Diseases : Lung Cancer

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Mangosteen ethanol extract alleviated the severity of collagen-induced arthritis in rats and produced synergistic effects with methotrexate.Nov 30, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharm Biol. 2018 Dec ;56(1):455-464. PMID: 31070537

Article Published Date : Nov 30, 2018

Study Type : Animal Study

Additional Links

Substances : Mangosteen

Diseases : Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Interleukin-10 upregulation, Interleukin-17 downregulation

Additional Keywords : Natural Substance/Drug Synergy

[+]

Melatonin augments the effects of fluoxetine on depression.Oct 30, 2017

Click here to read the entire abstract

Pubmed Data : Neurosci Bull. 2017 Oct 31. Epub 2017 Oct 31. PMID: 29086908

Article Published Date : Oct 30, 2017

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Depression

Pharmacological Actions : Antidepressive Agents, Brain-derived neurotrophic factor modulator

Additional Keywords : Natural Substance/Drug Synergy

[+]

Metformin in combination with curcumin inhibits the growth, metastasis and angiogenesis of hepatocellular carcinoma.Aug 18, 2017

Click here to read the entire abstract

Pubmed Data : Mol Carcinog. 2017 Aug 19. Epub 2017 Aug 19. PMID: 28833603

Article Published Date : Aug 18, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Natural Substance/Drug Synergy

[+]

N-acetylcysteine dose-dependently improves the analgesic effect of acetaminophen.Jan 06, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Pharmacol Toxicol. 2021 Jan 7 ;22(1):4. Epub 2021 Jan 7. PMID: 33413696

Article Published Date : Jan 06, 2021

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Chronic Pain

Pharmacological Actions : Analgesics, Antinoceceptive

Additional Keywords : Medication Reduction, Natural Substance/Drug Synergy

[+]

N-acetylcysteine synergizes with oseltamivir in protecting mice from lethal influenza infection.Mar 31, 2007

Click here to read the entire abstract

Pubmed Data : Int J Immunopathol Pharmacol. 2007 Apr-Jun;20(2):349-54. PMID: 17624247

Article Published Date : Mar 31, 2007

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Influenza

Pharmacological Actions : Antiviral Agents

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Oseltamivir (trade name Tamiflu)

[+]

NAC restores T-cell numbers in tumors and increases the ability of M30 and aOX40 to slow tumor growth in mice.Sep 29, 2020

Click here to read the entire abstract

Pubmed Data : Gastroenterology. 2020 Sep 30. Epub 2020 Sep 30. PMID: 33010248

Article Published Date : Sep 29, 2020

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Liver Cancer

Pharmacological Actions : Immunomodulatory

Additional Keywords : Natural Substance/Drug Synergy

[+]

Nardostachys jatamansi root extract could increase in the protective index of phenytoin.Nov 30, 2005

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2005 Dec 1 ;102(3):351-6. Epub 2005 Aug 10. PMID: 16095854

Article Published Date : Nov 30, 2005

Study Type : Animal Study

Additional Links

Substances : Spikenard

Diseases : Seizures

Pharmacological Actions : Anticonvulsants

Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts

[+]

Neuroprotective effect of combining tanshinone IIA with low-dose methylprednisolone following acute spinal cord injury.Apr 30, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Ther Med. 2017 May ;13(5):2193-2202. Epub 2017 Mar 28. PMID: 28565827

Article Published Date : Apr 30, 2017

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Spinal Cord Injuries

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Nordihydroguaiaretic acid enhances the activities of aminoglycosides against methicillin- sensitive and resistant Staphylococcus aureus.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Microbiol. 2015 ;6:1195. Epub 2015 Oct 27. PMID: 26579101

Article Published Date : Dec 31, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Nordihydroguaiaretic acid (NDGA)

Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Oleanolic acid combined with olaparib enhances radiosensitization in triple negative breast cancer and hypoxia.Apr 24, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2022 Apr 25 ;150:113007. Epub 2022 Apr 25. PMID: 35483190

Article Published Date : Apr 24, 2022

Study Type : Animal Study

Additional Links

Substances : Oleanolic acid

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Radiosensitizer

Additional Keywords : Natural Substance/Drug Synergy

[+]

Oleocanthal combined with lapatinib treatment synergized against HER-2 positive breast cancer.Feb 14, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2019 Feb 15 ;11(2). Epub 2019 Feb 15. PMID: 30781364

Article Published Date : Feb 14, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Oleocanthal

Diseases : Breast Cancer

Pharmacological Actions : Anti-metastatic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment.Aug 01, 2019

Click here to read the entire abstract

Pubmed Data : Cell Oncol (Dordr). 2019 Aug 2. Epub 2019 Aug 2. PMID: 31376137

Article Published Date : Aug 01, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Phenethyl isothiocyanate

Diseases : Breast Cancer, Ovarian Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Cancer Stem Cells, Natural Substance/Drug Synergy

[+]

Phloretin potentiates polymyxin E activity against gram-negative bacteria.Dec 14, 2021

Click here to read the entire abstract

Pubmed Data : Life Sci. 2021 Dec 15 ;287:120085. Epub 2021 Oct 23. PMID: 34699905

Article Published Date : Dec 14, 2021

Study Type : Animal Study

Additional Links

Diseases : Salmonella Infections

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Pioglitazone plus nettle has synergistic protective effects against STZ-induced nephropathy.Apr 30, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Basic Med Sci. 2017 May ;20(5):497-502. PMID: 28656084

Article Published Date : Apr 30, 2017

Study Type : Animal Study

Additional Links

Substances : Nettle

Diseases : Diabetic Nephropathy

Pharmacological Actions : Antioxidants, Renoprotective

Additional Keywords : Natural Substance/Drug Synergy

[+]

Propolis acted synergistically with cefixime and enhanced the efficacy of antibiotic and reduced its effective dose in combined therapy.Nov 24, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2016 Nov 25 ;16(1):485. Epub 2016 Nov 25. PMID: 27887651

Article Published Date : Nov 24, 2016

Study Type : Animal Study

Additional Links

Substances : Bee Propolis

Diseases : Salmonella Infections

Additional Keywords : Medication Reduction, Natural Substance/Drug Synergy

[+]

Puerarin and 5 FU combined exhibited a significantly greater effect than either drug alone, with the tumor inhibition rate reaching 89.06%.Oct 31, 2014

Click here to read the entire abstract

Pubmed Data : Mol Med Rep. 2014 Nov ;10(5):2535-41. Epub 2014 Sep 5. PMID: 25189132

Article Published Date : Oct 31, 2014

Study Type : Animal Study

Additional Links

Substances : Puerarin

Diseases : Esophageal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Drug: 5-flourouracil, Natural Substance/Drug Synergy

[+]

Quercetin could be a favourable antifungal agent and a promising synergist with fluconazole.Nov 29, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell Physiol Biochem. 2016 Nov 30 ;40(3-4):727-742. Epub 2016 Nov 30. PMID: 27915337

Article Published Date : Nov 29, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Quercetin

Diseases : Candida Albicans, Candidiasis: Vulvovaginal

Pharmacological Actions : Antifungal Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Quercetin enhances the antitumor effect of trichostatin A and prevents its induced muscle wasting.Jan 01, 2018

Click here to read the entire abstract

Pubmed Data : Food Funct. 2018 Jan 2. Epub 2018 Jan 2. PMID: 29292417

Article Published Date : Jan 01, 2018

Study Type : Animal Study

Additional Links

Substances : Quercetin

Diseases : Cachexia: Cancer, Lung Cancer

Pharmacological Actions : Anti-Cachexic Agents, Chemosensitizer

Additional Keywords : Natural Substance/Drug Synergy

[+]

Quercetin has anti-myeloma activity both in vitro and in vivo.Jun 13, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2016 Jun 14. Epub 2016 Jun 14. PMID: 27329589

Article Published Date : Jun 13, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Quercetin

Diseases : Multiple Myeloma

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Drug: Dexamethasone, Natural Substance/Drug Synergy

[+]

Recombinant human lactoferrin enhances the efficacy of triple therapy in mice infected with Helicobacter pylori.Jul 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Med. 2015 Aug ;36(2):363-8. Epub 2015 Jun 17. PMID: 26080893

Article Published Date : Jul 31, 2015

Study Type : Animal Study

Additional Links

Substances : Lactoferrin

Diseases : Helicobacter Pylori Infection, Inflammation

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Resistance to cetuximab in human colon cancer patients with a mutant KRAS can be bypassed by L-ascorbic acid in an SVCT-2-dependent manner.Mar 21, 2016

Click here to read the entire abstract

Pubmed Data : Free Radic Biol Med. 2016 Mar 22 ;95:200-208. Epub 2016 Mar 22. PMID: 27012422

Article Published Date : Mar 21, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Vitamin C

Diseases : Cancers: Drug Resistant, Colon Cancer

Pharmacological Actions : Apoptotic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Resveratrol improved the effect of sulfamethoxazole-trimethoprim in reducing oxidative damage, liver damage and the number of cysts in the brain.Apr 03, 2016

Click here to read the entire abstract

Pubmed Data : Microb Pathog. 2016 Apr 4 ;95:166-174. Epub 2016 Apr 4. PMID: 27057672

Article Published Date : Apr 03, 2016

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Toxoplasma gondii Infection

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Natural Substance/Drug Synergy

[+]

Silibinin augments the effect of clopidogrel on atherosclerosis.Sep 30, 2021

Click here to read the entire abstract

Pubmed Data : Clin Hemorheol Microcirc. 2021 Oct 1. Epub 2021 Oct 1. PMID: 34602463

Article Published Date : Sep 30, 2021

Study Type : Animal Study

Additional Links

Substances : Silibinin

Diseases : Atherosclerosis

Additional Keywords : Natural Substance/Drug Synergy

[+]

Soluble β-glucan from Grifola frondosa induces tumor regression in synergy with TLR9 agonist.Nov 30, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Leukoc Biol. 2015 Dec ;98(6):1015-25. Epub 2015 Aug 21. PMID: 26297795

Article Published Date : Nov 30, 2015

Study Type : Animal Study

Additional Links

Substances : Beta-glucan, Maitake Mushroom

Diseases : Colon Cancer

Pharmacological Actions : Immunomodulatory, Interleukin-12 upregulation

Additional Keywords : Natural Substance/Drug Synergy

[+]

Standardised ginseng extract potentiates the antidepressant-like properties of fluoxetine.Jan 21, 2021

Click here to read the entire abstract

Pubmed Data : Acta Neuropsychiatr. 2021 Jan 22:1-7. Epub 2021 Jan 22. PMID: 33478610

Article Published Date : Jan 21, 2021

Study Type : Animal Study

Additional Links

Substances : Ginseng

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Supplementation of vitamin E may improve the efficacy of standard and experimental cancer therapies by subsiding the toxic effect of the antineoplastic agent.Mar 31, 2015

Click here to read the entire abstract

Pubmed Data : Hum Exp Toxicol. 2015 Apr ;34(4):380-9. Epub 2014 Oct 10. PMID: 25304969

Article Published Date : Mar 31, 2015

Study Type : Animal Study

Additional Links

Substances : Vitamin E: alpha tocopherol

Diseases : Cardiotoxicity: Chemotherapy-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Cardioprotective, Chemoprotective Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Synergistic actions of vitamin D and metformin on skeletal muscles and insulin resistance of type 2 diabetic rats.Dec 01, 2017

Click here to read the entire abstract

Pubmed Data : J Cell Physiol. 2017 Dec 2. Epub 2017 Dec 2. PMID: 29205344

Article Published Date : Dec 01, 2017

Study Type : Animal Study

Additional Links

Substances : Vitamin D

Diseases : Diabetes Mellitus: Type 2

Additional Keywords : Natural Substance/Drug Synergy

[+]

Synergistic combination of N-acetylcysteine and ribavirin to protect from lethal influenza viral infection in a mouse model.Dec 31, 2003

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Immunopathol Pharmacol. 2004 Jan-Apr;17(1):99-102. PMID: 15000873

Article Published Date : Dec 31, 2003

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Influenza A

Pharmacological Actions : Antioxidants, Antiviral Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Synergistic effect of chlorogenic acid and levofloxacin against Klebsiella pneumonia infection.Jan 16, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2020 11 17 ;10(1):20013. Epub 2020 Nov 17. PMID: 33203903

Article Published Date : Jan 16, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Chlorogenic Acid

Diseases : Klebsiella Infections, Klesiella Pneumonia Infection

Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

Synergistic effect of polyphenol-rich complex of plant and green propolis extracts with antibiotics against respiratory Infections causing bacteria.Jan 25, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antibiotics (Basel). 2022 Jan 26 ;11(2). Epub 2022 Jan 26. PMID: 35203763

Article Published Date : Jan 25, 2022

Study Type : Animal Study

Additional Links

Substances : Propolis: Bee

Diseases : Respiratory Infections

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Synergistic effects of combined anthocyanin and metformin treatment for hyperglycemia.Jan 18, 2022

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2022 Jan 19. Epub 2022 Jan 19. PMID: 35044756

Article Published Date : Jan 18, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Anthocyanins

Diseases : Hyperglycemia

Pharmacological Actions : Gastrointestinal Agents, Hypoglycemic Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Synergistic effects of magnesium ions and simvastatin on attenuation of high-fat diet-induced bone loss.Jul 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Bioact Mater. 2021 Aug ;6(8):2511-2522. Epub 2021 Feb 3. PMID: 33665494

Article Published Date : Jul 31, 2021

Study Type : Animal Study

Additional Links

Substances : Magnesium

Diseases : Hyperlipidemia

Pharmacological Actions : Osteoprotective

Additional Keywords : Natural Substance/Drug Synergy

[+]

Synergistic inhibition of lung cancer cells by EGCG and NF-κB inhibitor BAY11-7082.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Cancer. 2019 ;10(26):6543-6556. Epub 2019 Oct 21. PMID: 31777584

Article Published Date : Dec 31, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Pharmacological Actions : Antiproliferative , NF-kappaB Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

Tanacetum parthenium enhances pentobarbital-induced sleeping behaviors.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Avicenna J Phytomed. 2020 Jan-Feb;10(1):70-77. PMID: 31921609

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Feverfew

Diseases : Sleep Disorders

Pharmacological Actions : Hypnotics and Sedatives

Additional Keywords : Natural Substance/Drug Synergy

[+]

The addition of curcumin to FOLFOX based chemotherapy enhances efficacy in patient derived CRLM cultures.Aug 09, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Lett. 2015 Aug 10 ;364(2):135-41. Epub 2015 May 12. PMID: 25979230

Article Published Date : Aug 09, 2015

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Colorectal Cancer, Liver Metastasis From Colon Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemotherapeutic

Additional Keywords : Cancer Stem Cells, Drug: Oxaliplatin, Natural Substance/Drug Synergy

[+]

The administration of EGCG after sunitinib treatment represents a promising strategy for the treatment of cancer.Jan 04, 2016

Click here to read the entire abstract

Pubmed Data : Tumour Biol. 2016 Jan 5. Epub 2016 Jan 5. PMID: 26733173

Article Published Date : Jan 04, 2016

Study Type : Animal Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Breast Cancer, Lung Cancer

Pharmacological Actions : Antiproliferative , Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Natural Substance/Drug Synergy

[+]

The combination of auranofin and vitamin C could be efficient against triple-negative breast cancer.Nov 19, 2018

Click here to read the entire abstract

Pubmed Data : J Natl Cancer Inst. 2018 Nov 20. Epub 2018 Nov 20. PMID: 30462268

Article Published Date : Nov 19, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Vitamin C

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Chemosensitizer, Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

[+]

The combination of CS plus metronomic ZOL demonstrated significant antitumor, anti-metastatic and anti-osteolytic effects against breast cancerMay 19, 2015

Click here to read the entire abstract

Pubmed Data : Oncol Rep. 2015 May 20. Epub 2015 May 20. PMID: 25998578

Article Published Date : May 19, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Green Tea

Diseases : Breast Cancer

Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Zoledronic Acid

[+]

The combination of nigella sativa oil and pyrimethamine had a synergistic effect in the treatment of toxoplasmosis.Oct 06, 2015

Click here to read the entire abstract

Pubmed Data : Parasitol Res. 2015 Oct 7. Epub 2015 Oct 7. PMID: 26446086

Article Published Date : Oct 06, 2015

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Toxoplasma gondii Infection, Toxoplasmosis

Therapeutic Actions : Integrative Medicine

Pharmacological Actions : Antioxidants

Additional Keywords : Natural Substance/Drug Synergy

[+]

The combination of pomegranate juice and tolbutamide exhibited profound protection compared to tolbutamide alone against diabetic complications.Nov 30, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Integr Med Res. 2017 Dec ;6(4):354-360. Epub 2017 Aug 1. PMID: 29296562

Article Published Date : Nov 30, 2017

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Diabetic Complications

Pharmacological Actions : Antinoceceptive

Additional Keywords : Natural Substance/Drug Synergy

[+]

The combination of ursolic acid and empagliflozin relieves diabetic nephropathy.Oct 05, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2021 Oct 6 ;144:112267. Epub 2021 Oct 6. PMID: 34624679

Article Published Date : Oct 05, 2021

Study Type : Animal Study

Additional Links

Substances : Ursolic Acid

Diseases : Diabetic Nephropathy

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Renoprotective

Additional Keywords : Natural Substance/Drug Synergy

[+]

the combination of vitamin C with benznidazole could be considered as an alternative treatment for Chagas' disease.Sep 20, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS Negl Trop Dis. 2018 Sep 21 ;12(9):e0006764. Epub 2018 Sep 21. PMID: 30240395

Article Published Date : Sep 20, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Vitamin C

Diseases : Chagas Disease

Pharmacological Actions : Antiparasitic Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

The dietary use of the green dwarf banana flour constitutes an important dietary supplement and complementary medicine product for the prevention and treatment of human inflammatory bowel disease.Feb 29, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutr Res. 2012 Mar ;32(3):202-9. PMID: 22464807

Article Published Date : Feb 29, 2012

Study Type : Animal Study

Additional Links

Substances : Banana, Resistant Starch

Diseases : Colitis, Inflammatory Bowel Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Gastrointestinal Agents

Additional Keywords : Dietary Modification, Natural Substance/Drug Synergy

Problem Substances : Prednisolone

[+]

The effect of coenzyme Q10 on liver injury induced by valproic acid and its antiepileptic activity.Jan 12, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomedicines. 2022 Jan 13 ;10(1). Epub 2022 Jan 13. PMID: 35052847

Article Published Date : Jan 12, 2022

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Anticonvulsants

Additional Keywords : Natural Substance/Drug Synergy

[+]

The overall results suggest that combination of mangiferin with both metformin and gliclazide alleviates diabetic conditions.Mar 21, 2019

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Pubmed Data : Phytomedicine. 2019 Mar 22 ;59:152901. Epub 2019 Mar 22. PMID: 30981189

Article Published Date : Mar 21, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Mangiferin

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Hypoglycemic Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

The results of this study indicate that dry olive leaf extract possesses strong antimelanoma potential.Apr 14, 2011

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Cancer. 2011 Apr 15 ;128(8):1955-65. PMID: 20568104

Article Published Date : Apr 14, 2011

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Diseases : Chemotherapy-Induced Toxicity, Malignant Melanoma, Melanoma, Skin Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Chemotherapeutic

Additional Keywords : Natural Substance/Drug Antagonism, Natural Substance/Drug Synergy, Plant Leaves, Temozolomide

Problem Substances : Cisplatin, Doxorubicin, Paclitaxel

[+]

The role of beetroot extract in overcoming chemoresistance of neoadjuvant adriamycin cyclophosphamide regimen.Feb 28, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Cancer Prev. 2022 Mar 1 ;23(3):1061-1068. Epub 2022 Mar 1. PMID: 35345381

Article Published Date : Feb 28, 2022

Study Type : Animal Study

Additional Links

Substances : Beet

Diseases : Breast Cancer

Pharmacological Actions : Chemosensitizer, Immunomodulatory

Additional Keywords : Chemotherapeutic Agent: Cyclophosphamide, Natural Substance/Drug Synergy, Tumor Microenvironment

[+]

The therapeutic effects of berberine plus sitagliptin in a rat model of fatty liver disease.Mar 31, 2021

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Pubmed Data : Iran J Basic Med Sci. 2021 Apr ;24(4):451-459. PMID: 34094026

Article Published Date : Mar 31, 2021

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Fatty Liver, Hyperlipidemia

Pharmacological Actions : Hypolipidemic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Theanine significantly enhanced the repression of liver cancer cell growth in combination with anticancer drug pirarubicin.Sep 08, 2016

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Pubmed Data : J Agric Food Chem. 2016 Sep 9. Epub 2016 Sep 9. PMID: 27569455

Article Published Date : Sep 08, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Theanine

Diseases : Liver Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , NF-kappaB Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

Therapeutic potentials of 6-gingerol in combination with amphotericin B for treatment of Leishmania major infection.Nov 30, 2021

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Pubmed Data : Int Immunopharmacol. 2021 Dec ;101(Pt B):108274. Epub 2021 Oct 21. PMID: 34688150

Article Published Date : Nov 30, 2021

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Gingerol

Diseases : Leishmaniasis

Pharmacological Actions : Leishmanicidal

Additional Keywords : Natural Substance/Drug Synergy

[+]

There is a close interaction between curcumin and cholinergic system, and curcumin may have protective effects on cholinergic system.Mar 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Basic Med Sci. 2015 Apr ;18(4):398-403. PMID: 26019804

Article Published Date : Mar 31, 2015

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Cognitive Decline/Dysfunction, Memory Loss

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Nicotine

[+]

There was a synergistic and potentiating effect of grapefruit juice and aripriprazole.Mar 22, 2018

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Pubmed Data : BMC Complement Altern Med. 2018 Mar 23 ;18(1):106. Epub 2018 Mar 23. PMID: 29566693

Article Published Date : Mar 22, 2018

Study Type : Animal Study

Additional Links

Substances : Grapefruit

Diseases : Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

Additional Keywords : Natural Substance/Drug Synergy

[+]

These data suggest that the gabapentin and mangiferin combination produces a synergistic interaction at the peripheral level.Nov 30, 2017

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Pubmed Data : Drug Dev Res. 2017 Dec ;78(8):390-402. Epub 2017 Sep 20. PMID: 28940250

Article Published Date : Nov 30, 2017

Study Type : Animal Study

Additional Links

Substances : Mangiferin

Diseases : Neuropathic Pain

Additional Keywords : Mangiferin, Natural Substance/Drug Synergy, Neuropathic Pain

[+]

These findings support the rationale of using natural remedies in conjunction with classical pharmacological agents to treat chronic neuropathic pain.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2019 ;10:711. Epub 2019 Jun 27. PMID: 31316381

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Beta-Caryophyllene, Carnosic Acid, Myrrh, Palmitoylethanolamide

Diseases : Neuropathic Pain

Pharmacological Actions : Analgesics

Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts

[+]

These initial results indicate a potential for the combination of posaconazole with tomatidine against T. cruzi.Dec 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Cell Infect Microbiol. 2021 ;11:617917. Epub 2021 Mar 4. PMID: 33747979

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Tomatidine

Diseases : Trypanosomiasis

Pharmacological Actions : Antiparasitic Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

These results demonstrate that parthenolide potentiates the efficacy of balsalazide.Jan 31, 2017

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Pubmed Data : Mol Cancer Res. 2017 Feb ;15(2):141-151. Epub 2016 Nov 14. PMID: 28108625

Article Published Date : Jan 31, 2017

Study Type : Animal Study

Additional Links

Substances : Parthenolide

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative , NF-kappaB Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

This study demonstrated the results of interactions between ascorbic acid and tramadol or morphine.Jul 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Anesth Pain Med. 2014 Aug ;4(3):e19529. Epub 2014 Jun 22. PMID: 25289375

Article Published Date : Jul 31, 2014

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Pharmacological Actions : Analgesics, Antinoceceptive

Additional Keywords : Dose Response, Natural Substance/Drug Synergy

[+]

This study established a new mechanism for using EGCG as an adjuvant chemotherapy agent through modifying microvasculature and microenvironments. Apr 30, 2013

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Pubmed Data : Chin J Nat Med. 2013 May ;11(3):245-53. PMID: 23725836

Article Published Date : Apr 30, 2013

Study Type : Animal Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Carcinoma: Non-Small-Cell Lung, Chemotherapy-Induced Toxicity: Cisplatin, Lung Cancer

Pharmacological Actions : Anti-Angiogenic, Antineoplastic Agents, Antiproliferative , Chemosensitizer, Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Cisplatin

[+]

This study highlights the potential therapeutic usefulness of curcumin as an adjunct in patients with chemoresistant advanced CRC. Feb 28, 2015

Click here to read the entire abstract

Pubmed Data : Carcinogenesis. 2015 Mar ;36(3):355-67. Epub 2015 Feb 4. PMID: 25653233

Article Published Date : Feb 28, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cancers: Drug Resistant, Chemotherapy-Induced Toxicity: 5-fluorouracil , Colorectal Cancer

Pharmacological Actions : Chemosensitizer, MicroRNA modulator

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Fluorouracil (5-FU or f5U)

[+]

This study shows for the first time that carnosic acid and trastuzumab cooperate in inhibiting breast cancer cell migration and survival.Nov 02, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Exp Clin Cancer Res. 2017 Nov 3 ;36(1):154. Epub 2017 Nov 3. PMID: 29100552

Article Published Date : Nov 02, 2017

Study Type : Animal Study

Additional Links

Substances : Carnosic Acid

Diseases : Breast Cancer

Pharmacological Actions : Cell cycle arrest, Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Thymoquinone can enhance the anticancer activity of bortezomib in vitro and in vivoFeb 14, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2014 Feb 15 ;5(3):634-48. PMID: 24504138

Article Published Date : Feb 14, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Thymoquinone

Diseases : Multiple Myeloma

Pharmacological Actions : Antiproliferative , Apoptotic, NF-kappaB Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

Thymoquinone increased the potency of valproate in both PTZ and MES models.Dec 31, 2007

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Health Sci (Qassim). 2008 Jan ;2(1):15-25. PMID: 21475467

Article Published Date

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View the Evidence: 562 Abstracts with Natural Substance/Drug Synergy Research

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A review of the beneficial effects of antioxidants on Helicobacter pylori eradication.Nov 30, 2018

Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis.Dec 31, 2018

Honeysuckle combined with conventional therapy may be beneficial for the treatment of COVID-19 in improving lung CT, clinical cure rate, clinical symptoms.Dec 31, 2020

Specific combinations of traditional medicines appeared to produce higher contributions to tumor response rate than the TMs individually.Aug 05, 2015

The addition of probiotics to standard therapy is associated with improved H. pylori eradication rates in both children and adults.Dec 31, 2015

Bee products are effective in symptomatic treatment of upper respiratory tract infections.Dec 31, 2019

Probiotic Bifidobacterium longum supplied with methimazole improved the thyroid function of Graves' disease patients through the gut-thyroid axis Jan 06, 2021

"Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer."Feb 28, 2011

Adding Berberis vulgaris fruit extract on metronidazole improve the efficacy of bacterial vaginosis therapy.Jul 31, 2016

Adding M. communis extract to metronidazole increases the efficiency of bacterial vaginosis treatment.Feb 28, 2017

Addition of epigallocatechin gallate 400 mg to sofosbuvir 400 mg + daclatisvir 60 mg in in treatment of patients with chronic hepatitis C.Jan 18, 2019

Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection.Nov 20, 2012

Antimicrobial activity of Prunella Vulgaris extracts against multi-drug resistant Escherichia Coli from patients of urinary tract infection.Apr 30, 2018

Application of Peganum harmala seed can be useful in reducing urinary symptoms in patients with benign prostatic hyperplasia.Dec 31, 2016

Black cumin seeds decreased Methotrexate hepatotoxicity and improved survival in children with ALLMar 19, 2015

Cannabis users report greater pain relief in combination with opioids than when opioids are used alone.Jan 31, 2015

Clinical efficacy of acetylcysteine combined with tetrandrine tablets on patients with silicosis.Jul 31, 2020

Curcumin could reverse the development of depression and enhance the outcome of antidepressants treatment in major depressive disorder.Jul 31, 2015

Curcumin may be a safe and effective therapy for maintenance of remission in quiescent UC when given as adjunctive therapy along with mesalamine or sulfasalazine. Dec 31, 2011

Curcuminoids with piperine may be used as a safe and effective add on to standard antidepressants in patients with major depressive disorders.Dec 31, 2014

Helicobacter pylori eradication: Sequential therapy and Lactobacillus reuteri supplementation.Nov 20, 2012

Lavandula angustifilia infusion has some positive therapeutic effects on depressed patients most importantly decreases mean depression score and might be used alone or as an adjunct to other anti-depressant drugs.Jul 31, 2013

Milled flaxseed lowers total and LDL cholesterol in patients with peripheral artery disease.Mar 31, 2015

N-acetylcysteine combined with dexamethasone treatment improves sudden sensorineural hearing loss.Dec 31, 2020

Preparation and optimization of garlic oil/apple vider vinegar nanoemulsion loaded with minoxidil to treat alopecia.Dec 13, 2021

Prunella vulgaris may be a potential adjuvant medicine for breast cancer treatment.Dec 31, 2017

Silibinin may improve the effects of methotrexate on certain biochemical and clinical markers of patients with active rheumatoid arthritis.Jun 30, 2016

Somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide led to an overall clinical benefit been achieved in 75% of cases.Dec 31, 2012

Synergism of allicin in combination with itraconazole and terbinafine, which could be a reference for the treatment of tinea capitis due to M. canis.Dec 31, 2020

The addition of POMx to simvastatin therapy in hypercholesterolemic patients improved oxidative stress and lipid status in the patient's serum and in their HMDM. Dec 31, 2013

The administration of soybean could enhance the response to SSRI anti depressants in menopausal women.Feb 28, 2014

The administration of soybean could enhance the response to SSRI anti depressants in menopausal women.Feb 28, 2014

The combination of bevacizumab and tocotrienol is potent in chemotherapy refractory ovarian cancer. Feb 28, 2019

The combination of serenoa repens, selenium, lycopene and bromelain are beneficial in patients with chronic bacterial prostatitis.Oct 04, 2016

The combined use of echinacea with azithromycin produced favourable outcome than azithromycin alone in pediatric patients with recurrent tonsillitis.Jul 31, 2020

The potential prebiotic berberine combined with methimazole improved the therapeutic effect of Graves' disease patients.Dec 31, 2020

6-shogaol, 6-gingerol and pterostilbene selectively killed breast cancer stem cells.Mar 10, 2015

Amurensin G. was a potent SIRT1 Inhibitor which led to the down regulation of multidrug resistance.Oct 31, 2010

Combinations of EGCG and anticancer compounds induced synergistic anticancer effects in vitro and in vivo experiments, and showed an average reduction in tumor volume by 70.3 %.Aug 31, 2015

Findings suggest that Plantago ovata husk could be a potentially useful adjuvant in chemotherapy for colorectal cancer.Jun 01, 2012

Hydrocortisone and ascorbic acid synergistically prevent and repair lipopolysaccharide-induced pulmonary endothelial barrier dysfunction.Jan 10, 2017

Piperine enhanced mitomycin-C therapy in human cervical cancer cells.Nov 19, 2017

Prunella vulgaris has potent anti-Ebola virus activity and may be developed as a novel antiviral approach against EBOV infection.Feb 29, 2016

Pterostilbene might be used to modulate two anticancer compounds in well-defined sets of GBM patients.Nov 07, 2016

The combination of centchroman with genistein has selective cytotoxic effect for human breast cancer cell lines.Oct 31, 2016

These results suggest deguelin could have potential for the treatment of human CLL.Dec 31, 2015

Beetroot-carrot juice can be used as an effective treatment for CLL alone or in combination with chlorambucil.Jun 14, 2015

Omalizumab ensures compatibility to bee venom immunotherapy (VIT) after VIT-induced anaphylaxis in a patient with systemic mastocytosis.Dec 31, 2020

Synergistic effect of oridonin and a PI3K/mTOR inhibitor on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma.Jan 22, 2016

The combination of Biochanin A and SB590885 potentiates the inhibition of tumour progression in hepatocellular carcinoma.Dec 31, 2019

The dual roles of ginsenosides in improving the anti-tumor efficiency of cyclophosphamide in mammary carcinoma mice. Aug 23, 2020

A combination of ascorbate with Amphotericin B is a potentially effective treatment that may reduce nephrotoxicity in patients with systemic candidiasis.Jul 31, 2015

Achillea fragrantissima, rich in flavonoids and tannins, potentiates the activity of diminazine aceturate against Trypanosoma evansi in rats.Feb 29, 2016

Additive antiangiogenesis effect of ginsenoside Rg3 with low-dose metronomic temozolomide on rat glioma cells both in vivo and in vitro.Feb 12, 2016

AGE showed synergistic effects with NTX on inhibition of tumor growth and increment of survival times.Jun 30, 2013

Alleviation of fructose-induced Alzheimer's disease in rats by pioglitazone and decaffeinated green coffee bean extract.Apr 30, 2021

Alpha-tocopherol attenuates the anti-tumor activity of crizotinib against cells transformed by NPM-ALK.Dec 31, 2016

An extract of Allspice was shown to be effective in decreasing the growth of MB231 tumors by oral administration, and this effect was greater when pretreated with AAE as a chemo-preventive agent.Apr 13, 2015

Anthocyanins work in synergy with trastuzumab by induced apoptosis, inhibited cell growth and affected HER2 downstream signaling.Sep 30, 2014

Anti-tumor activity of tanshinone IIA in combined with cyclophosphamide against Lewis mice with lung cancer.Jan 10, 2016

Anticancer effects of combination of indole-3-carbinol and hydroxychloroquine on ehrlich ascites carcinoma.Aug 10, 2021

Antinociceptive synergy between metamizole and hesperidin. Jan 18, 2021

Ascorbic acid protects against the nephrotoxicity and apoptosis caused by colistin and affects its pharmacokinetics.Jan 31, 2012

Aspalathin from rooibos improves the hypoglycemic potential of metformin in type 2 diabetic mice.Nov 13, 2018

Baicalein enhances the effect of acarbose on the improvement of nonalcoholic fatty liver disease associated with prediabetes.Aug 31, 2021

Berberine might be a promising synergist to enhance the antimicrobial activity of azithromycin in vitro and in vivo.Jul 23, 2017

Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells.Apr 18, 2004

Calcitriol enhanced the efficacy of irinotecan in growth inhibition and apoptosis induction.Jul 24, 2016

Chrysanthemum indicum could enhance the anti-cancer activity of bleomycin and reduce the its induced pulmonary injury in H22 tumor-bearing mice.Feb 23, 2017

Chrysin strengthened the therapeutic efficacy of docetaxel and diminished the adverse effect of it.May 04, 2016

Cinnamaldehyde enhances antimelanoma activity through covalently binding ENO1 and exhibits a promoting effect with dacarbazine.Jan 28, 2020

Co-administration of carrot fruit significantly enhanced both ulcer preventive effects and ulcer healing properties of the pantoprazole.Nov 12, 2020

Natural Substance/Drug Synergy

View the Evidence:
562 Abstracts with Natural Substance/Drug Synergy Research