Natural Substance/Drug Synergy

Name	AC	CK
Antibiotics	8	28
Fluoxetine (trade name Prozac)	2	20
Methotrexate	1	20
Sertraline	2	20
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	2	11
Antidepressants	1	10
Mesalamine	1	10
Simvastatin	1	10
Statin Drugs	1	10
Doxorubicin	2	7
Cisplatin	2	4
Diclofenac	2	4
Fluorouracil (5-FU or f5U)	1	2
Glibenclamide	1	2
Nicotine	1	2
Oseltamivir (trade name Tamiflu)	1	2
Paclitaxel	1	2
Prednisolone	1	2
Zoledronic Acid	1	2
Atorvastatin	1	1
Dexamethasone	1	1
Herceptin	1	1
Indomethacin	1	1

Name	AC	CK
Breast Cancer	52	87
Helicobacter Pylori Infection	12	69
Depression	8	56
Colorectal Cancer	19	47
Rheumatoid Arthritis	5	34
Staphylococcus aureus infection	29	31
Cancers: All	23	28
Escherichia coli Infections	17	26
Cancers: Drug Resistant	18	25
Lung Cancer	17	24
Oxidative Stress	10	24
Breast Cancer: Triple Negative	16	23
Candida Albicans	20	22
Liver Cancer	17	22
Infection: Antibiotic Resistant	12	21
Ovarian Cancer	6	21
Pseudomonas aeruginosa	20	21
Bacterial Vaginosis	2	20
Depression: Postmenopausal	2	20
Diarrhea: Antibiotic-Associated	1	20
Colon Cancer	14	17
Staphylococcus aureus: Methicillin-resistant (MRSA)	15	16
Chronic Pain	4	15
Chemotherapy-Induced Toxicity: Cyclophosphamide	3	14
Acute lymphoblastic leukemia (ALL)	3	12
Carcinoma: Non-Small-Cell Lung	9	12
Cervical Cancer	7	12
Melanoma	9	12
Multiple Myeloma	9	12
Ulcerative Colitis	2	11
Anxiety Disorders	1	10
Atherosclerosis	1	10
Breast Cancer: Metastatic	1	10
C-Reactive Protein	1	10
Cholesterol: High	1	10
Colorectal Adenomas	1	10
Depressive Disorder	1	10
Drug-Induced Toxicity: Methotrexate	1	10
Gastric Cancer	7	10
Hearing Loss: Sudden	1	10
High Cholesterol	1	10
Inflammation	7	10
Leukemia	10	10
Neuropathic Pain	5	10
Peripheral Arterial Disease	1	10
Prostate Cancer	8	10
Prostatic Hyperplasia	1	10
Prostatitis: Bacterial	1	10
Silicosis	1	10
Tonsillitis	1	10
Triglycerides: Elevated	1	10
Upper Respiratory Infections	1	10
Urinary Tract Infections	1	10
Candida Infection	8	8
Diabetes Mellitus: Type 2	4	8
Glioblastoma	7	8
Sepsis	3	8
Arthritis	4	7
Chronic Lymphocytic Leukemia	3	7
Glioma	5	7
Mycobacterium tuberculosis	7	7
Pancreatic Cancer	6	7
Acinetobacter baumannii infection	6	6
Allodynia	3	6
Breast Cancer Stem Cells	2	6
Breast Cancer: Drug Resistant	2	6
Glioblastoma Multiforme	2	6
Klebsiella Infections	5	6
Skin Cancer	4	6
Ebola Virus Infections	1	5
Endothelial Dysfunction	1	5
Lipopolysaccharide-Induced Toxicity	1	5
Acute Myeloid Leukemia	4	4
Alzheimer's Disease	3	4
Esophageal Cancer	3	4
Hyperalgesia	2	4
Hyperglycemia	2	4
Lipid Peroxidation	2	4
Lymphoma: B-Cell	2	4
Malignant Melanoma	2	4
Promyelocytic leukemia	4	4
Seizures: Drug-Induced	2	4
Toxoplasma gondii Infection	2	4
Bacterial Infections	3	3
Cachexia: Cancer	2	3
Cancer Metastasis	2	3
Cancers: Multi-Drug Resistant	3	3
Chemotherapy-Induced Toxicity	2	3
Chemotherapy-Induced Toxicity: Bleomycin	2	3
Chemotherapy-Induced Toxicity: Cisplatin	2	3
Coronavirus Infection	3	3
Epilepsy	2	3
HIV Infections	3	3
Leishmaniasis	2	3
Leukemia: Chronic Lymphocytic Leukemia (CLL)	1	3
Mastocytosis	1	3
Osteosarcoma	3	3
Salmonella Infections	2	3
Staphylococcus epidermidis	3	3
Trypanosomiasis	2	3
Wound Healing	2	3
Aspirin-Induced Toxicity	1	2
Campylobacter Infections	2	2
Candida Glabrata	2	2
Candidiasis	1	2
Candidiasis: Vulvovaginal	1	2
Cardiotoxicity: Chemotherapy-Induced	1	2
Chagas Disease	1	2
Chemotherapy and Radiation Toxicity	1	2
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	2
Choriocarcinoma	2	2
Cognitive Decline/Dysfunction	1	2
Colitis	1	2
Cryptococcosis	1	2
Diabetic Complications	1	2
Diabetic Nephropathy	1	2
Dyslipidemias	1	2
Enterococcus Infections	2	2
Fibrosarcoma	1	2
Gastric Ulcer	1	2
Gram-Negative Bacterial Infections	2	2
Gram-Positive Bacterial Infections	2	2
Hyperlipidemia	1	2
Inflammatory Bowel Diseases	1	2
Influenza	1	2
Influenza A	1	2
Kidney Cancer	2	2
Kidney Damage: Chemically-Induced	1	2
Kidney Damage: Drug-Induced	1	2
Klesiella Pneumonia Infection	1	2
Laryngeal Cancer	2	2
Leukemia: Chronic myelogenous leukemia (CML)	2	2
Liver Metastasis From Colon Cancer	1	2
Memory Loss	1	2
Morphine Tolerance/Dependence	1	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Osteoarthritis	1	2
Osteoporosis	1	2
Parasitic Diseases	1	2
Seizures	1	2
Sleep Disorders	1	2
Spinal Cord Injuries	1	2
Squamous cell carcinoma	2	2
Steptococcus Mutans Infections	2	2
Toxoplasmosis	1	2
AIDS	1	1
Animal Cancers	1	1
Autoimmune Diseases	1	1
Bacterial Infections: Resistance/Biofilm Formation	1	1
Bladder Cancer	1	1
Bone Cancer	1	1
Brain Cancer	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Cancer: Pain	1	1
Cancers: Canine	1	1
Carcinosarcomas	1	1
Cardiovascular Disease	1	1
Chemotherapy	1	1
Chemotherapy-Induced Toxicity: Doxorubicin	1	1
Chemotherapy-Induced Toxicity: Tamoxifen	1	1
Cystic Fibrosis	1	1
Cytomegalovirus Infections	1	1
Diabesity	1	1
Epileptic Seizures	1	1
Fungal Infection	1	1
Fungal Infections: Biofilm Formation/Resistance	1	1
Fungus Diseases	1	1
Head and Neck Cancer	1	1
Headache	1	1
Hepatitis B	1	1
Hepatitis C	1	1
Herpes Simplex Virus Type 1	1	1
Herpes Simplex Virus Type 2	1	1
Hypoglycemia	1	1
Leukemia: Acute myelogenous leukemia (AML)	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Listeria Infections	1	1
Lyme Borreliosis	1	1
Lyme Disease	1	1
Malaria	1	1
Measles	1	1
Medulloblastoma	1	1
Melanoma: Metastatic	1	1
Multiple Sclerosis	1	1
Mycobacterium abscessus	1	1
Neurofibromatosis	1	1
Non-Hodgkin's lymphoma: B Cell	1	1
Oral Cancer	1	1
Parkinson's Disease	1	1
Periodontal Diseases	1	1
Peripheral Neuropathies	1	1
Radiation Induced Illness	1	1
Retinoblastoma	1	1
Rhabdomyosarcoma	1	1
Schwannoma	1	1
Spondylitis: Ankylosing	1	1
Staphylococcal Infections	1	1
Streptococcus pyogenes	1	1
Tuberculosis: Drug Resistant	1	1

Name	AC	CK
Curcumin	39	95
NAC (N-acetyl-L-cysteine)	8	49
Vitamin C	30	44
Probiotics	3	31
Prunella vulgaris	3	25
EGCG (Epigallocatechin gallate)	17	24
Vitamin D	11	22
Berberine	19	21
Chinese Skullcap	2	21
Astragalus	1	20
Cranberry	1	20
Hedyotis corymbosa	1	20
Peony	1	20
Soy	2	20
Quercetin	15	18
Melatonin	7	17
Pomegranate	6	16
Ginsenosides	10	15
Silibinin	6	15
Bee Propolis	4	14
Nigella sativa (aka Black Seed)	3	14
Fucoidan	4	13
Pterostilbene	5	13
Cannabis	3	12
Lycopene	2	12
Bromelain	2	11
Echinacea	2	11
Green Tea	5	11
Barberry	1	10
Bee Products	1	10
Flaxseed	1	10
Honey	1	10
Lactobacillus reuteri	1	10
Lavender	1	10
Myrtle	1	10
Piperidines	1	10
Royal Jelly	1	10
Saw Palmetto	1	10
Selenium	1	10
Syrian rue	1	10
Tocotrienol: Delta	1	10
Bee Venom	7	9
Piperine	5	9
Thymoquinone	7	9
Cannabidiol	7	8
Catechin	4	8
Mangiferin	6	8
Oridonin	7	8
Parthenolide	7	8
Resveratrol	7	8
Gingerol	3	7
Honokiol	6	7
Polyphenols	7	7
Tanshinone IIA	5	7
Wogonin	4	7
Carnosic Acid	4	6
Genistein	2	6
Luteolin	5	6
Sulforaphane	5	6
6-Shogaol	1	5
Amurensin G	1	5
Carrot	2	5
Deguelin	1	5
Garlic	5	5
Nordihydroguaiaretic acid (NDGA)	4	5
Plantago major	1	5
Beet	2	4
Beta-Elemene	4	4
Cannabinoids	4	4
Cannabinoids: Synthetic	2	4
Emodin	4	4
Ginkgo biloba	3	4
Indole-3-Carbinol	4	4
Lactoferrin	3	4
Olive leaf extract	3	4
Turmeric	4	4
Vitamin E: alpha tocopherol	2	4
Anthocyanins	2	3
Artesunate	3	3
Baicalein	3	3
Beta-Caryophyllene	2	3
Betulinic acid	2	3
Biochanin A	2	3
Caffeic Acid	3	3
Chlorogenic Acid	2	3
Chrysin	2	3
Cinnamaldehyde	2	3
Cinnamon	3	3
Gallic Acid	2	3
Ginger	3	3
Guduchi	2	3
Hesperidin	2	3
Magnolol	3	3
Mangosteen	2	3
Nobiletin	2	3
Oleocanthal	2	3
Puerarin	2	3
Rosmarinic acid	3	3
Tomatidine	2	3
Vitamin E: Gamma-tocotrienol	3	3
Vitamin K	3	3
Achillea fragrantissima	1	2
Allicin	2	2
Allspice	1	2
Ashwagandha	1	2
Astaxanthin	2	2
Banana	1	2
Basil	2	2
Beta-glucan	1	2
Black Tea	2	2
Bufalin	2	2
Capsaicin	2	2
Chrysanthemum Indicum	1	2
Corn Silk	1	2
Curcumol	2	2
Cyanidin 3-glucoside	1	2
DHA (Docosahexaenoic Acid)	2	2
Dandelion	1	2
Devils Claw	1	2
Ellagic Acid	1	2
Eugenol	2	2
Evening Primrose Oil	1	2
False Black Pepper	1	2
Ferulic acid	2	2
Feverfew	1	2
Formononetin	2	2
Garlic: Aged	1	2
Genipin	1	2
Geraniol	2	2
Ginseng	1	2
Grape Seed Extract	2	2
Grapefruit	1	2
Honeysuckle	1	2
Hyperforin	1	2
Isothiocyanates	2	2
L-Carnitine	1	2
Lemongrass	1	2
Magnesium	1	2
Maitake Mushroom	1	2
Manuka Honey	2	2
Myricetin	2	2
Myrrh	1	2
Naringenin	1	2
Nettle	1	2
Onion	2	2
Oregano	2	2
Palmitoylethanolamide	1	2
Panax Notoginseng	1	2
Phenethyl isothiocyanate	1	2
Piperlongumine	2	2
Punicalagin	2	2
Resistant Starch	1	2
Rhubarb	1	2
Rooibos	1	2
Safflower	1	2
Silver (nanoparticles)	2	2
Silymarin	2	2
Spikenard	1	2
Tangeretin	2	2
Tetrahydrocurcumin	1	2
Theanine	1	2
Thiamine (B-1)	2	2
Tocotrienol: Gamma	1	2
Ursolic Acid	2	2
Valerian	1	2
Vanillin	2	2
Vitamin E	1	2
Zinc	2	2
Adlay	1	1
Aloe Vera	1	1
Antrodia cinnamomea	1	1
Arctigenin	1	1
Artemisinin	1	1
Asparagus	1	1
Astragaloside	1	1
Beans: All	1	1
Benzyl isothiocyanate	1	1
Bergamot orange	1	1
Beta-sesquiphellandrene	1	1
Bitter Melon	1	1
Black Currant	1	1
Blueberry	1	1
Breast Milk	1	1
Burdock	1	1
Cafestol	1	1
Caffeic acid phenethyl ester	1	1
Carnosol	1	1
Carvacrol	1	1
Cayenne	1	1
Celastrol	1	1
Celery seed	1	1
Chia	1	1
Chokeberry	1	1
Citral	1	1
Citrus naringin	1	1
Crocin	1	1
Cruciferous Vegetables	1	1
Cucurbitacin B	1	1
Delta-tetrahydrocannabinol (THC)	1	1
Demethoxycurcumin	1	1
Diosmin	1	1
Epicatechin	1	1
Erucin	1	1
Feijoa	1	1
Folic Acid	1	1
Fruit: All	1	1
Fucoxanthin	1	1
Galbanic Acid	1	1
Ginseng (Korean)	1	1
Glycyrrhizin	1	1
Gold (nanoparticles)	1	1
Grape	1	1
Griffithsin	1	1
Haritaki (Terminalia chebula)	1	1
Hibiscus sabdariffa	1	1
Homeopathic Medicine: All	1	1
Honeybush	1	1
Iodine	1	1
Isomangiferin	1	1
Isoquercitrin	1	1
Kaempferol	1	1
Kudzu	1	1
L-arginine	1	1
Lichens	1	1
Lutein	1	1
Magnolia	1	1
Maple Syrup	1	1
Modified Arabinoxylan Rice Bran (MGN-3)	1	1
Modified Citrus Pectin	1	1
Mulberry	1	1
Oleanolic acid	1	1
Oleuropein	1	1
Olive	1	1
Paeonol	1	1
Pelargonium graveolens	1	1
Peppermint	1	1
Perilla	1	1
Phellinus Linteus	1	1
Phloretin	1	1
Piceatannol	1	1
Plum	1	1
Propolis: Bee	1	1
Pyrogallol	1	1
Riboflavin (Vitamin B-2)	1	1
Rice Bran	1	1
Rosemary	1	1
Salvia miltiorrhiza	1	1
Sea buckthorn	1	1
Seaweed	1	1
Seaweed: Brown	1	1
Sesamol	1	1
Shikonin	1	1
Tannic Acid	1	1
Theaflavins	1	1
Thyme	1	1
Tocotrienols	1	1
Tomato	1	1
Vegetables: All	1	1
Vitamin A	1	1
Vitamin B-12	1	1
Vitamin B-6	1	1
Vitamin C: Intravenous	1	1
Vitamin K2	1	1
Watercress	1	1
Wheat Grass	1	1
White Tea	1	1
beta-Carotene	1	1

Name	AC	CK	Focus
Exercise	1	10
Integrative Medicine	2	3

Name	AC	CK
Antiproliferative	115	152
Apoptotic	115	150
Anti-Bacterial Agents	71	130
Chemotherapeutic	69	110
Chemosensitizer	68	109
Antioxidants	31	96
Anti-Inflammatory Agents	33	92
Antidepressive Agents	8	56
Antimicrobial	37	47
Antineoplastic Agents	31	39
Anti-metastatic	28	38
Cell cycle arrest	28	36
Hepatoprotective	4	34
Tumor Necrosis Factor (TNF) Alpha Inhibitor	9	31
Chemoprotective Agents	17	30
NF-kappaB Inhibitor	20	30
Gastroprotective	5	26
Antiviral Agents	14	25
Analgesics	8	21
Chemopreventive	11	19
Interleukin-6 Downregulation	8	18
Immunomodulatory	12	17
Angiogenesis Inhibitors	12	16
Interleukin-1 beta downregulation	5	16
Matrix metalloproteinase-9 (MMP-9) inhibitor	10	15
Antifungal Agents	12	14
Bcl-2 protein down-regulation	8	14
Cyclooxygenase 2 Inhibitors	10	14
Hypoglycemic Agents	8	14
Anti-Angiogenic	8	12
Antinoceceptive	6	12
Interleukin-8 downregulation	3	12
Vascular Endothelial Growth Factor Inhibitors	7	11
Anti-atherogenic	1	10
Anticholesteremic Agents	1	10
Hypolipidemic	1	10
Matrix metalloproteinase-2 (MMP-2) inhibitor	7	10
Neuroprotective Agents	7	10
Renoprotective	5	9
Cyclin D1 Down-Regulation	3	8
Anti-Tumor	2	7
Anticonvulsants	4	7
Antiparasitic Agents	4	7
MicroRNA modulator	5	6
Anti-Retroviral Agents	1	5
Gastrointestinal Agents	3	5
Tumor Suppressor Protein p53 Upregulation	5	5
Anticarcinogenic Agents	4	4
Brain-derived neurotrophic factor modulator	2	4
Cardioprotective	3	4
Interleukin-12 upregulation	2	4
Malondialdehyde Down-regulation	2	4
Osteoprotective	2	4
Anti-Ulcer Agents	2	3
Cyclooxygenase Inhibitors	2	3
Leishmanicidal	2	3
Nrf2 activation	2	3
Superoxide Dismutase Up-regulation	2	3
Vascular Endothelial Growth Factor A Inhibitor	2	3
AKT-mammalian target of rapamycin (mTOR) pathway inhibitor	1	2
Acetylcholinesterase Inhibitor	1	2
Angiogenesis Inducing Agents	1	2
Anti-Apoptotic	2	2
Anti-Cachexic Agents	1	2
Anti-HIV Agents	2	2
Autophagy Up-regulation	1	2
Cytotoxic	2	2
Hypnotics and Sedatives	1	2
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	2
Interferon Gamma Reducer	1	2
Interleukin-10 downregulation	1	2
Interleukin-10 upregulation	1	2
Interleukin-17 downregulation	1	2
Interleukin-4 downregulation	1	2
Multidrug Resistance Gene Modulators	2	2
Nitric Oxide Enhancer	1	2
P21 Activation	2	2
Radioprotective	2	2
Radiosensitizer	2	2
STAT3 Inhibitor	2	2
Survivin Down-Regulation	2	2
Vascular Endothelial Growth Factor C Inhibitor	1	2
Wnt/β-catenin signaling pathway modulation	2	2
apoptosis	1	2
Alpha-glucosidase inhibitor	1	1
Appetite Stimulants	1	1
Bcl-xL down-regulation	1	1
Heat Shock Protein Inducer	1	1
Histone deacetylase inhibitor	1	1
Interleukin-12 downregulation	1	1
Interleukin-23 Downregulation	1	1
Photoprotective	1	1
Postaglandin PGE2 downregulation	1	1
Quorum Sensing Inhibition	1	1
Reactive Oxygen Species (ROS) attenuation	1	1
Reverse Transcriptase Inhibitors	1	1

[+]

A review of the beneficial effects of antioxidants on Helicobacter pylori eradication.Nov 30, 2018

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Pubmed Data : Helicobacter. 2018 Dec ;23(6):e12535. Epub 2018 Sep 6. PMID: 30191635

Article Published Date : Nov 30, 2018

Study Type : Meta Analysis, Review

Additional Links

Substances : Cranberry, Curcumin, NAC (N-acetyl-L-cysteine)

Diseases : Helicobacter Pylori Infection

Pharmacological Actions : Anti-Bacterial Agents, Antioxidants

Additional Keywords : Natural Substance/Drug Synergy

[+]

Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis.Dec 31, 2018

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Pubmed Data : Drug Des Devel Ther. 2019 ;13:1969-1984. Epub 2019 Jun 17. PMID: 31354242

Article Published Date : Dec 31, 2018

Study Type : Meta Analysis

Additional Links

Substances : Peony

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Methotrexate

[+]

Specific combinations of traditional medicines appeared to produce higher contributions to tumor response rate than the TMs individually.Aug 05, 2015

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Pubmed Data : J Clin Psychopharmacol. 2015 Aug ;35(4):406-10. PMID: 26066335

Article Published Date : Jul 31, 2015

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Depression

Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance/Drug Synergy, Significant Treatment Outcome

Problem Substances : Antidepressants

[+]

Curcumin may be a safe and effective therapy for maintenance of remission in quiescent UC when given as adjunctive therapy along with mesalamine or sulfasalazine. Dec 31, 2011

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Pubmed Data : Pharmaceutics. 2021 Dec 14 ;13(12). Epub 2021 Dec 14. PMID: 34959435

Article Published Date : Dec 13, 2021

Study Type : Human Study

Additional Links

Substances : Apple Cider Vinegar, Garlic

Diseases : Alopecia

Additional Keywords : Natural Substance/Drug Synergy

[+]

Prunella vulgaris may be a potential adjuvant medicine for breast cancer treatment.Dec 31, 2017

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[+]

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Pubmed Data : J Exp Clin Cancer Res. 2016 Feb 13 ;35:32. Epub 2016 Feb 13. PMID: 26872471

Article Published Date : Feb 12, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Glioblastoma

Pharmacological Actions : Anti-Angiogenic, Antiproliferative , Cell cycle arrest

Additional Keywords : Natural Substance/Drug Synergy

[+]

AGE showed synergistic effects with NTX on inhibition of tumor growth and increment of survival times.Jun 30, 2013

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Pubmed Data : Mol Med Rep. 2014 Oct ;10(4):1921-6. Epub 2014 Jul 22. PMID: 25070704

Article Published Date : Sep 30, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Anthocyanins, Cyanidin 3-glucoside

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Anti-Tumor, Antiproliferative , apoptosis

Additional Keywords : Drug: Trastuzumab, Natural Substance/Drug Synergy, Supplements

[+]

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Pubmed Data : Drug Deliv. 2018 Nov ;25(1):1779-1789. PMID: 30338719

Article Published Date : Oct 31, 2018

Study Type : Animal Study

Additional Links

Substances : Safflower

Diseases : Wound Healing

Pharmacological Actions : Angiogenesis Inducing Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Combination of berberine with pentoxifylline illustrated a synergistic effect in attenuation of diclofenac-induced acute kidney injury.Mar 31, 2019

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Pubmed Data : Front Pharmacol. 2019 ;10:1249. Epub 2019 Oct 25. PMID: 31708779

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : False Black Pepper

Diseases : Seizures: Drug-Induced

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Endostar combined with ginsenoside Rg3 has stronger inhibiting effect on breast cancer tumor growth in tumor-bearing mice than single drug.Jan 31, 2016

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Pubmed Data : Cancer Cell Int. 2019 ;19:68. Epub 2019 Mar 21. PMID: 30948928

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Lycopene

Diseases : Lung Cancer

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

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Mangosteen ethanol extract alleviated the severity of collagen-induced arthritis in rats and produced synergistic effects with methotrexate.Nov 30, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharm Biol. 2018 Dec ;56(1):455-464. PMID: 31070537

Article Published Date : Nov 30, 2018

Study Type : Animal Study

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Substances : Mangosteen

Diseases : Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Interleukin-10 upregulation, Interleukin-17 downregulation

Additional Keywords : Natural Substance/Drug Synergy

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Synergistic effects of magnesium ions and simvastatin on attenuation of high-fat diet-induced bone loss.Jul 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Mol Carcinog. 2017 Mar 30. Epub 2017 Mar 30. PMID: 28370562

Article Published Date : Mar 29, 2017

Study Type : Animal Study

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Substances : Vitamin C

Diseases : Malignant Melanoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic

Additional Keywords : Natural Substance/Drug Synergy

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Vitamin C enhances the analgesic effect of gabapentin on rats with neuropathic pain.Jul 14, 2016

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Pubmed Data : Life Sci. 2016 Jul 15 ;157:25-31. Epub 2016 May 28. PMID: 27245275

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Pubmed Data : Expert Opin Investig Drugs. 2012 Jun ;21(6):819-31. Epub 2012 Apr 16. PMID: 22500582

Article Published Date : May 31, 2012

Study Type : Review

Additional Links

Substances : Melatonin

Diseases : Breast Canc

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View the Evidence: 528 Abstracts with Natural Substance/Drug Synergy Research

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A review of the beneficial effects of antioxidants on Helicobacter pylori eradication.Nov 30, 2018

Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis.Dec 31, 2018

Specific combinations of traditional medicines appeared to produce higher contributions to tumor response rate than the TMs individually.Aug 05, 2015

The addition of probiotics to standard therapy is associated with improved H. pylori eradication rates in both children and adults.Dec 31, 2015

Bee products are effective in symptomatic treatment of upper respiratory tract infections.Dec 31, 2019

"Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer."Feb 28, 2011

Adding Berberis vulgaris fruit extract on metronidazole improve the efficacy of bacterial vaginosis therapy.Jul 31, 2016

Adding M. communis extract to metronidazole increases the efficiency of bacterial vaginosis treatment.Feb 28, 2017

Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection.Nov 20, 2012

Antimicrobial activity of Prunella Vulgaris extracts against multi-drug resistant Escherichia Coli from patients of urinary tract infection.Apr 30, 2018

Application of Peganum harmala seed can be useful in reducing urinary symptoms in patients with benign prostatic hyperplasia.Dec 31, 2016

Black cumin seeds decreased Methotrexate hepatotoxicity and improved survival in children with ALLMar 19, 2015

Cannabis users report greater pain relief in combination with opioids than when opioids are used alone.Jan 31, 2015

Clinical efficacy of acetylcysteine combined with tetrandrine tablets on patients with silicosis.Jul 31, 2020

Curcumin could reverse the development of depression and enhance the outcome of antidepressants treatment in major depressive disorder.Jul 31, 2015

Curcumin may be a safe and effective therapy for maintenance of remission in quiescent UC when given as adjunctive therapy along with mesalamine or sulfasalazine. Dec 31, 2011

Curcuminoids with piperine may be used as a safe and effective add on to standard antidepressants in patients with major depressive disorders.Dec 31, 2014

Helicobacter pylori eradication: Sequential therapy and Lactobacillus reuteri supplementation.Nov 20, 2012

Lavandula angustifilia infusion has some positive therapeutic effects on depressed patients most importantly decreases mean depression score and might be used alone or as an adjunct to other anti-depressant drugs.Jul 31, 2013

Milled flaxseed lowers total and LDL cholesterol in patients with peripheral artery disease.Mar 31, 2015

N-acetylcysteine combined with dexamethasone treatment improves sudden sensorineural hearing loss.Dec 31, 2020

Preparation and optimization of garlic oil/apple vider vinegar nanoemulsion loaded with minoxidil to treat alopecia.Dec 13, 2021

Prunella vulgaris may be a potential adjuvant medicine for breast cancer treatment.Dec 31, 2017

Silibinin may improve the effects of methotrexate on certain biochemical and clinical markers of patients with active rheumatoid arthritis.Jun 30, 2016

Somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide led to an overall clinical benefit been achieved in 75% of cases.Dec 31, 2012

Synergism of allicin in combination with itraconazole and terbinafine, which could be a reference for the treatment of tinea capitis due to M. canis.Dec 31, 2020

The addition of POMx to simvastatin therapy in hypercholesterolemic patients improved oxidative stress and lipid status in the patient's serum and in their HMDM. Dec 31, 2013

The administration of soybean could enhance the response to SSRI anti depressants in menopausal women.Feb 28, 2014

The administration of soybean could enhance the response to SSRI anti depressants in menopausal women.Feb 28, 2014

The combination of bevacizumab and tocotrienol is potent in chemotherapy refractory ovarian cancer. Feb 28, 2019

The combination of serenoa repens, selenium, lycopene and bromelain are beneficial in patients with chronic bacterial prostatitis.Oct 04, 2016

The combined use of echinacea with azithromycin produced favourable outcome than azithromycin alone in pediatric patients with recurrent tonsillitis.Jul 31, 2020

6-shogaol, 6-gingerol and pterostilbene selectively killed breast cancer stem cells.Mar 10, 2015

Amurensin G. was a potent SIRT1 Inhibitor which led to the down regulation of multidrug resistance.Oct 31, 2010

Combinations of EGCG and anticancer compounds induced synergistic anticancer effects in vitro and in vivo experiments, and showed an average reduction in tumor volume by 70.3 %.Aug 31, 2015

Findings suggest that Plantago ovata husk could be a potentially useful adjuvant in chemotherapy for colorectal cancer.Jun 01, 2012

Hydrocortisone and ascorbic acid synergistically prevent and repair lipopolysaccharide-induced pulmonary endothelial barrier dysfunction.Jan 10, 2017

Piperine enhanced mitomycin-C therapy in human cervical cancer cells.Nov 19, 2017

Prunella vulgaris has potent anti-Ebola virus activity and may be developed as a novel antiviral approach against EBOV infection.Feb 29, 2016

Pterostilbene might be used to modulate two anticancer compounds in well-defined sets of GBM patients.Nov 07, 2016

The combination of centchroman with genistein has selective cytotoxic effect for human breast cancer cell lines.Oct 31, 2016

These results suggest deguelin could have potential for the treatment of human CLL.Dec 31, 2015

Beetroot-carrot juice can be used as an effective treatment for CLL alone or in combination with chlorambucil.Jun 14, 2015

Omalizumab ensures compatibility to bee venom immunotherapy (VIT) after VIT-induced anaphylaxis in a patient with systemic mastocytosis.Dec 31, 2020

Synergistic effect of oridonin and a PI3K/mTOR inhibitor on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma.Jan 22, 2016

The combination of Biochanin A and SB590885 potentiates the inhibition of tumour progression in hepatocellular carcinoma.Dec 31, 2019

The dual roles of ginsenosides in improving the anti-tumor efficiency of cyclophosphamide in mammary carcinoma mice. Aug 23, 2020

A combination of ascorbate with Amphotericin B is a potentially effective treatment that may reduce nephrotoxicity in patients with systemic candidiasis.Jul 31, 2015

Achillea fragrantissima, rich in flavonoids and tannins, potentiates the activity of diminazine aceturate against Trypanosoma evansi in rats.Feb 29, 2016

Additive antiangiogenesis effect of ginsenoside Rg3 with low-dose metronomic temozolomide on rat glioma cells both in vivo and in vitro.Feb 12, 2016

AGE showed synergistic effects with NTX on inhibition of tumor growth and increment of survival times.Jun 30, 2013

Alleviation of fructose-induced Alzheimer's disease in rats by pioglitazone and decaffeinated green coffee bean extract.Apr 30, 2021

Alpha-tocopherol attenuates the anti-tumor activity of crizotinib against cells transformed by NPM-ALK.Dec 31, 2016

An extract of Allspice was shown to be effective in decreasing the growth of MB231 tumors by oral administration, and this effect was greater when pretreated with AAE as a chemo-preventive agent.Apr 13, 2015

Anthocyanins work in synergy with trastuzumab by induced apoptosis, inhibited cell growth and affected HER2 downstream signaling.Sep 30, 2014

Anti-tumor activity of tanshinone IIA in combined with cyclophosphamide against Lewis mice with lung cancer.Jan 10, 2016

Antinociceptive synergy between metamizole and hesperidin. Jan 18, 2021

Ascorbic acid protects against the nephrotoxicity and apoptosis caused by colistin and affects its pharmacokinetics.Jan 31, 2012

Aspalathin from rooibos improves the hypoglycemic potential of metformin in type 2 diabetic mice.Nov 13, 2018

Baicalein enhances the effect of acarbose on the improvement of nonalcoholic fatty liver disease associated with prediabetes.Aug 31, 2021

Berberine might be a promising synergist to enhance the antimicrobial activity of azithromycin in vitro and in vivo.Jul 23, 2017

Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells.Apr 18, 2004

Calcitriol enhanced the efficacy of irinotecan in growth inhibition and apoptosis induction.Jul 24, 2016

Chrysanthemum indicum could enhance the anti-cancer activity of bleomycin and reduce the its induced pulmonary injury in H22 tumor-bearing mice.Feb 23, 2017

Chrysin strengthened the therapeutic efficacy of docetaxel and diminished the adverse effect of it.May 04, 2016

Cinnamaldehyde enhances antimelanoma activity through covalently binding ENO1 and exhibits a promoting effect with dacarbazine.Jan 28, 2020

Co-administration of carrot fruit significantly enhanced both ulcer preventive effects and ulcer healing properties of the pantoprazole.Nov 12, 2020

Co-administration of EGb 761 and donepezil exerted better anti-amnestic effect.Dec 24, 2020

Co-administration of hyperforin and lanicemine induces long-lasting antidepressant effects.Dec 31, 2017

Co-delivery of deferoxamine and hydroxysafflor yellow A to accelerate diabetic wound healing via enhanced angiogenesis.Oct 31, 2018

Combination of berberine with pentoxifylline illustrated a synergistic effect in attenuation of diclofenac-induced acute kidney injury.Mar 31, 2019

Combination of curcumin and mitomycin C can synergistically inhibit tumor growth in MCF-7 breast cancer xenografts and induce apoptosis in breast cancer MCF-7 cells.Dec 31, 2013

Natural Substance/Drug Synergy

View the Evidence:
528 Abstracts with Natural Substance/Drug Synergy Research