Natural Substances Versus Drugs

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33 Problem Substances Researched for Natural Substances Versus Drugs

Name	AC	CK
Fluoxetine (trade name Prozac)	14	110
Mefenamic acid	5	50
Chlorhexidine gluconate	4	40
Diclofenac	5	34
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	5	28
Antibiotics	4	22
Ibuprofen	3	22
Statin Drugs	4	15
Simvastatin	2	12
Oseltamivir (trade name Tamiflu)	2	11
Acetaminophen	1	10
Gemfibrozil	1	10
Hydroxychloroquine sulfate	1	10
Memantine	1	10
Sertraline	1	10
Sodium Fluoride	1	10
Zanamivir	1	10
Indomethacin	2	4
Aspirin	2	3
Allopurinol	1	2
Atorvastatin	1	2
Benzene	1	2
Carrageenan	1	2
Cisplatin	2	2
Corticosteroid	1	2
Donepezil (trade name Aricept)	1	2
Methotrexate	1	2
Pioglitazone (trade Name Actos)	1	2
Rosiglitazone (trade name Avandia)	1	2
Uranium	1	2
Benzodiazepines	1	1
Prednisolone	1	1
Tamoxifen	1	1

342 Diseases Researched for Natural Substances Versus Drugs

Name	AC	CK
Depression	35	266
Dental Plaque	15	141
Osteoarthritis: Knee	13	130
Gingivitis	13	121
Osteoarthritis	12	95
Dysmenorrhea	9	90
Diabetes Mellitus: Type 2	22	80
Inflammation	31	76
Prostatic Hyperplasia: Benign	7	71
Alzheimer's Disease	12	53
Oxidative Stress	17	52
Steptococcus Mutans Infections	7	52
Hyperlipidemia	11	45
Dementia	5	44
Depressive Disorder	5	42
Dyspepsia	4	40
Obsessive-Compulsive Disorder	4	40
Urinary Tract Infections	4	40
Helicobacter Pylori Infection	8	38
Dental Caries	4	35
Pain	10	35
Allergic Rhinitis	5	34
Anxiety Disorders	4	34
Periodontal Diseases	6	33
Chronic Pain	3	32
Generalized Anxiety Disorder	2	30
Mastalgia	2	30
Menopausal Syndrome	4	30
Breast Cancer	13	29
Dyslipidemias	6	27
Hyperglycemia	15	27
Osteoporosis	5	26
Anxiety	5	25
Hypertension	4	24
Influenza	6	24
Depression	3	22
Gastric Ulcer	11	22
Insomnia	3	22
Acne	3	21
Periodontitis	3	21
Atrophic Vaginitis (Vaginal Atrophy)	2	20
Attention Deficit Disorder with Hyperactivity	2	20
Attention Deficit Hyperactivity Disorder	2	20
Candidiasis: Vulvovaginal	2	20
Clotting	2	20
Ear Infection	2	20
Epiphora	1	20
Head Lice	2	20
Hot Flash	2	20
Migraines	2	20
Otitis media	2	20
Postoperative Recovery	2	20
Radiation Induced Illness: Mucositis	2	20
Arthritis	10	19
Candida Albicans	8	18
Rheumatoid Arthritis	5	18
High Cholesterol	4	16
Liver Cancer	8	16
Staphylococcus aureus infection	6	16
Hypercholesterolemia	4	15
Obesity	4	15
Endothelial Dysfunction	3	14
Osteopenia	3	14
Thrombosis	3	14
Cardiovascular Diseases	4	13
Influenza A	4	13
Insulin Resistance	7	13
Arteriosclerosis	2	12
Bronchial Asthma	2	12
Bronchospasm: Acute	2	12
Depression: Postpartum	2	12
Diabetic Nephropathy	2	12
Gastroesophageal Reflux	2	12
Glaucoma	2	12
Gram-Negative Bacterial Infections	2	12
H1N1 Infection	3	12
Ocular Hypertension	2	12
Parkinson's Disease	2	12
Postmenopausal Disorders	3	12
Pulmonary Fibrosis	2	12
Uveitis	2	12
Cardiac Mortality	2	11
Clostridium Infections	2	11
Diarrhea	2	11
Fever	2	11
Giardiasis	2	11
Aging Skin	1	10
Alopecia: Androgenic	1	10
Amebiasis	1	10
Ammonia: Elevated	1	10
Aphthous Ulcer	1	10
Apnea	1	10
Bipolar Disorder	1	10
Blood Coagulation Disorders	1	10
Breast: Mammographic Density	1	10
Bronchitis: Acute	1	10
Bronchoconstriction: Exercise-Induced	1	10
Bunion	1	10
C-Reactive Protein	1	10
Carpal Tunnel Syndrome	1	10
Colic	1	10
Colitis: Ulcerative	1	10
Colonic Spasm	1	10
Constipation	1	10
Cramp	1	10
Dental Caries: Children	1	10
Diverticular Disease	1	10
Diverticulitis	1	10
Ecchymosis	1	10
Eczema	1	10
Edema	1	10
Endodontics	1	10
Endoscopy	1	10
Erythema	1	10
Febrile Infections	1	10
Fibromyalgia	1	10
Fungal Infection	1	10
Gallbladder Surgery: Removal	1	10
Genital Warts	1	10
H3N2 Infection	1	10
Halitosis	1	10
Head and Neck Cancer	1	10
Headache: Migraine	1	10
Hepatic Encephalopathy	1	10
Heroin Addiction/Withdrawal	1	10
Herpes Simplex: Labial	1	10
Human Papilloma Virus	1	10
IgA Nephropathy	1	10
Inflammatory Bowel Diseases	1	10
Interstitial Lung Diseases	1	10
Intraocular hypertension	1	10
Liver Cirrhosis	1	10
Melasma	1	10
Menstrual Cramps	1	10
Mucositis	1	10
Nail Fungus	1	10
Oral Lichen Planus	1	10
Pain: Musculoskeletal	1	10
Post-Thrombotic Syndrome	1	10
Postpartum Blood Loss	1	10
Postpartum Hemorrhage	1	10
Pregnancy: Morning Sickness	1	10
Quality of Life: Poor	1	10
Rhinitis	1	10
Scabies	1	10
Septic Shock	1	10
Sexual Dysfunction	1	10
Sinusitis: Acute	1	10
Sleep Disorders	1	10
Sore Throat	1	10
Suicidal Behavior	1	10
Tendinitis	1	10
Tendinopathy	1	10
Tendinosis	1	10
Tinnitus	1	10
Tonsillitis	1	10
Upper Respiratory Tract Symptoms	1	10
Urinary Tract Infections: Children	1	10
Urogenital Symptoms	1	10
Vaginal Dryness	1	10
Vertigo	1	10
Vesicoureteral reflux	1	10
Warts	1	10
Wound Healing: Periodontal	1	10
Wrinkles	1	10
Colorectal Cancer	6	8
Triglycerides: Elevated	5	8
Diabetic Complications	4	7
Melanoma	4	7
Wound Healing	2	7
Alcohol Toxicity	3	6
Asthma	3	6
Cognitive Decline/Dysfunction	3	6
Coronavirus Infection	4	6
High Fat Diet	3	6
Hyperuricemia	3	6
Blastocystis hominis infections	1	5
Candidiasis	1	5
Chemotherapy-Induced Toxicity: Cisplatin	3	5
Diabetes Mellitus: Type 1	3	5
Diabetes: Oxidative Stress	3	5
Epilepsy	3	5
Escherichia coli Infections	4	5
Gram-Positive Bacterial Infections	3	5
Hypoglycemia	3	5
Lipopolysaccharide-Induced Toxicity	4	5
Lung Cancer	3	5
Amnesia	2	4
Cancers: All	3	4
Chemotherapy and Radiation Toxicity	2	4
Gastric Cancer	3	4
Gastroduodenal Ulcer	2	4
High Fructose Diet	2	4
Myocardial Ischemia	2	4
Neuropathic Pain	2	4
Ovarian Cancer	4	4
Spinal Cord Injuries	2	4
Ulcers	2	4
Advanced Glycation End products (AGE)	2	3
Atherosclerosis	2	3
Brain: Oxidative Stress	2	3
Colon Cancer	2	3
Crigler-Najjar syndrome	1	3
Cytomegalovirus Infections	2	3
Enterococcus Infections	3	3
Gout	2	3
HIV Infections	2	3
Hyperbilirubinemia: Hereditary	1	3
Kidney Damage	2	3
Leishmaniasis	2	3
Leukemia	2	3
Oral Cancer	2	3
Pseudomonas aeruginosa	3	3
Rheumatism	2	3
Squamous cell carcinoma	2	3
Staphylococcus epidermidis	2	3
Toxoplasma gondii Infection	2	3
Toxoplasmosis	2	3
Acid Reflux	1	2
Air Pollution Linked Toxicity	1	2
Alcohol Withdrawal	1	2
Allergic Airway Diseases	1	2
Amnesia: Drug-Induced	1	2
Arthritis: Rheumatoid	1	2
Aspirin-Induced Toxicity	1	2
Atopic Dermatitis	1	2
Bacillus subtilis infections	2	2
Brain Inflammation	1	2
Breast Cancer: Triple Negative	2	2
Carcinoma: Non-Small-Cell Lung	1	2
Cardiomyopathy	1	2
Chemically-Induced Liver Damage	1	2
Chronic Kidney Disease (CKD)	1	2
Coccidiosis	1	2
Colitis	1	2
Colon Cancer: Prevention	1	2
Copper Toxicity	1	2
Corneal Diseases	1	2
Coronary Artery Spasm	1	2
DNA damage	2	2
Dandruff	1	2
Depression: Stress Related	1	2
Diabetes: Cognitive Dysfunction	1	2
Diabetes: Gestational	1	2
Diabetes: Glycation/A1C	1	2
Diabetes: Liver Disease	1	2
Diabetic Neuropathy	1	2
Diabetic Ulcer	1	2
Dog Diseases	1	2
Dry Eye Syndromes	1	2
Emesis	1	2
Estrogen Deficiency	1	2
Gastric Ulcers	1	2
Glioblastoma	1	2
Glioma	1	2
HDL: Low	1	2
Herpes Simplex Virus Type 1	2	2
High Sugar Diet	1	2
Hyperalgesia	1	2
Hyperinsulinism	1	2
Hyperthyroidism	2	2
Hypothyroidism	1	2
Incontinence: Urinary	1	2
Inflammation: Neutrophil-Mediated	1	2
Ischemia	1	2
Learning disorders	1	2
Liver Damage	1	2
Lung Injury: Acute	1	2
Lymphoma: Dalton's	1	2
Melanoma: Metastatic	1	2
Memory Disorders	1	2
Metabolic Diseases	1	2
Multiple Sclerosis	1	2
Myeloproliferative Disorders	1	2
Myointimal Hyperplasia	1	2
Neurodegenerative Diseases	1	2
Opiate Addiction/Withdrawal	1	2
Organ Transplantation: Heart	1	2
Osteoporosis: Male	1	2
Pain: General	1	2
Pancreatic Cancer	2	2
Parasitic Diseases	1	2
Parasitic Intestinal Diseases	1	2
Pica Syndrome	1	2
Prostatic Hyperplasia	1	2
Psoriasis	1	2
Pulmonary Hypertension	1	2
Right Ventricular Hypertrophy	1	2
Schistosomiasis	1	2
Schizophrenia	1	2
Sciatica	1	2
Skin Diseases	1	2
Smoking Cessation: Nicotine Addiction	1	2
Staphylococcus aureus: Methicillin-resistant (MRSA)	2	2
Stress	1	2
Stroke	1	2
Substance Withdrawal Syndrome	1	2
Thyroid Diseases	1	2
Traumatic Brain Injury	1	2
Trichinelliasis	1	2
Ulcerative Colitis	1	2
Uranium Poisoning	1	2
Uric Acid Nephropathy	1	2
Vaccination: Coronavirus	1	2
Actinomyces Infections	1	1
Acute lymphoblastic leukemia (ALL)	1	1
Aspergillosis	1	1
Avian Influenza	1	1
Bacterial Infections and Mycoses	1	1
Birth: Labor & Delivery	1	1
Breast Cancer: Estrogen	1	1
Breast Cancer: Metastatic	1	1
Cancers: Drug Resistant	1	1
Candida Glabrata	1	1
Candida Infection	1	1
Cough	1	1
Diabetes	1	1
Diabetes Mellitus: Type 2: Prevention	1	1
Diabetic Retinopathy	1	1
Epileptic Seizures	1	1
Fibrosis	1	1
Gastric Cancer: Prevention	1	1
Herpes Labialis	1	1
Infection: Antibiotic Resistant	1	1
Kidney Cancer	1	1
Lipid Peroxidation	1	1
Lymphoma	1	1
MRSA	1	1
Osteosarcoma	1	1
Post-Traumatic Stress Disorders (PTSD)	1	1
Prostate Cancer	1	1
Proteus Vulgaris Infections	1	1
Psychiatric Disorder: Conditioned Fear	1	1
Respiratory Syncytial Virus Infections	1	1
Respiratory Tract Infections	1	1
Salmonella Infections	1	1
Sterility	1	1
Thalassemia	1	1
Thyroid Cancer	1	1
Tumors	1	1
Venereal Diseases: Bacterial	1	1
Climacteric	1	0

1 Problematic Actions Researched for Natural Substances Versus Drugs

Name	AC	CK	Focus
Low Dose Ionizing Radiation	1	2

335 Substances Researched for Natural Substances Versus Drugs

Name	AC	CK
Saffron	13	150
Curcumin	28	103
Turmeric	14	100
Ginkgo biloba	10	95
Ginger	8	82
Homeopathic Medicine: All	9	82
Chamomile	7	66
Aloe Vera	8	54
Fennel	6	47
Nigella sativa (aka Black Seed)	10	45
Triphala	7	45
Saw Palmetto	4	41
Dill	4	40
Probiotics	4	40
St. John's Wort	3	40
Melatonin	7	38
Garlic	7	37
Berberine	7	34
Red Yeast Rice	5	32
Tea Tree	4	31
Arnica	3	30
Hyaluronic Acid	3	30
Lavender: Essential Oil	2	30
Olive	3	30
St. Johns Wort	7	29
Green Tea	5	25
Thyme	5	25
Genistein	4	24
Licorice	4	24
Lavender	4	23
Coconut Oil	3	22
Omega-3 Fatty Acids	3	22
Pomegranate	4	22
Sage	3	22
Almond	3	21
Catechin	3	21
Cinnamon	3	21
Clove	3	21
Evening Primrose Oil	2	21
Fig	3	21
Peppermint	3	21
Breast Milk	1	20
Caffeine	2	20
Calendula	2	20
Kava Kava	1	20
Lactobacillus Brevis	2	20
Milk Thistle	2	20
Mullein	2	20
Psilocybin	2	20
Tryptophan	2	20
Holy Basil	7	18
Oregano	3	17
Anthocyanins	4	15
Bacopa	3	14
Cannabidiol	9	14
Cumin	3	14
Echinacea	3	14
Pumpkin Seeds	3	14
Vitamin C	3	14
Mango	3	13
Policosanol	3	13
Rose	3	13
Bitter Melon	3	12
Cannabis	2	12
Chinese Skullcap	2	12
Flaxseed	2	12
Garcinia kola	2	12
Hibiscus sabdariffa	2	12
Homeopathic Medicine: Ambra grisea	2	12
Horsetail	2	12
Mucuna pruriens (aka Velvet Beans)	2	12
NAC (N-acetyl-L-cysteine)	2	12
Pumpkin Seed Oil/Meal	2	12
Soy	2	12
Valerian	2	12
White Mulberry	2	12
Cannabinoids	2	11
Chokeberry	2	11
Crocin	2	11
Delta-tetrahydrocannabinol (THC)	2	11
Elderberry	2	11
Eucalyptus	2	11
Fish Oil	2	11
Flavonoids	5	11
Guava	2	11
Magnesium	2	11
Vegetables: All	2	11
5-HTP (5-Hydroxytryptophan)	1	10
Amla Fruit	1	10
Apricot Kernel	1	10
Ayahuasca	1	10
Ayurvedic Formulations	1	10
Biochanin A	1	10
Black Cohosh	1	10
Black Pepper	1	10
Boswellia	1	10
Butterbur	1	10
Cabbage	1	10
Cashew	1	10
Castor oil	1	10
Celadrin	1	10
Cetyl Myristoleate	1	10
Chinense Herbal Formula: Jinniu	1	10
Chinese Herbal Formula: Shuang Huang Lian Wan	1	10
Chlorella (Algae)	1	10
Chlorogenic Acid	1	10
Chrysin	5	10
Coenzyme Q10	1	10
Cranberry	1	10
Curry Tree	1	10
EPA (Eicosapentaenoic Acid)	1	10
Ephedra sinica (Ma Huang)	1	10
Fiber	1	10
Folic Acid	1	10
Frankincense	1	10
Ginseng	1	10
Guggul	1	10
Homeopathic Medicine: Anamirta cocculus	1	10
Homeopathic Medicine: Conium maculatum	1	10
Homeopathic Medicine: Petroleum rectificatum	1	10
Homeopathic Medicine: Traumeel	1	10
Hops	1	10
Horseradish	1	10
Iron	1	10
Kanuka Honey	1	10
Lactobacillus paracasei	1	10
Lactobacillus reuteri	1	10
Lemon Balm	1	10
Manuka Honey	1	10
Methionine	1	10
Nasturtium	1	10
Niacin	1	10
Olive leaf extract	1	10
Ornithine	1	10
Peony	1	10
Piperidines	1	10
Psyllium	1	10
Rhodiola (Tibetan Ginseng)	1	10
SAMe (S-adenosylmethionine)	1	10
Saccharomyces Boulardii	1	10
Salt	1	10
Sesame Seed Oil	1	10
Sesame Seeds	1	10
Sesame oil: topical	1	10
Sodium Bicarbonate	1	10
Thai Herbal Formulations	1	10
Thiamine (B-1)	1	10
Traditional Tibetan Medicine: Zhi Byed 11	1	10
Vitamin B-6	1	10
Vitamin E	1	10
Wintergreen	1	10
Thymoquinone	5	9
Moringa oleifera	4	8
Polyphenols	5	8
Safflower	4	8
EGCG (Epigallocatechin gallate)	5	7
Pomegranate Peel	2	7
Purslane	4	7
Quercetin	4	7
Syrian rue	4	7
Banana	3	6
Bee Propolis	3	6
Coconut	3	6
Cucurbitacin B	3	6
Lotus	3	6
Allicin	3	5
Fucoidan	3	5
Guduchi	3	5
Rutin	3	5
Spirulina	3	5
Xanthones	3	5
Apigenin	3	4
Cissus quadrangularis	2	4
Coconut Water	2	4
Cordyceps Militaris	2	4
Dates	2	4
Equol	2	4
Fenugreek	3	4
Garden Cress (Lepidium sativum)	2	4
Henna	2	4
Krill	3	4
Lettuce	2	4
Naringenin	2	4
Palash	2	4
Plantago	2	4
Tanshinone IIA	2	4
Astaxanthin	2	3
Crocetin	2	3
Gotu Kola	2	3
Grapefruit Seed Extract	2	3
Graviola	2	3
Neem	3	3
Nettle	2	3
Nobiletin	2	3
Oyster Mushroom	2	3
Piperine	2	3
Propolis: Bee	2	3
Propolis: Brazillian	3	3
Puerarin	2	3
Tannic Acid	2	3
Vitamin D	2	3
Acai	1	2
Acorus calamus	1	2
Anise	1	2
Arginine	1	2
Arjuna	1	2
Artemisinin	2	2
Artesunate	1	2
Ashwagandha	1	2
Asiatic Acid	1	2
Baccharis dracunculifolia	1	2
Bael	1	2
Bay leaf	1	2
Beet	1	2
Beta-Caryophyllene	1	2
Black Tea	1	2
Carnosol	1	2
Carvacrol	1	2
Chicory	1	2
Cinnamaldehyde	1	2
Coconut Milk	1	2
Coriandrum sativum	1	2
Cucumber	1	2
Fermented Foods and Beverages	1	2
Fisetin	1	2
Fucoidan: topical	1	2
Gac	1	2
Gardenia	1	2
Gingerol	1	2
Goji	1	2
Grape	1	2
Guarana	1	2
Hawthorn	1	2
Hesperidin	1	2
Homeopathic Treatment: Pulsatilla nigricans	1	2
Hydrogen Water	1	2
Isoflavones	1	2
Jujube	1	2
Justicia gendarussa	1	2
Linden (Tilia)	1	2
Lycopene	1	2
Muskmelon	1	2
Mussel: Green-lipped (Perna canaliculus)	1	2
Myrrh	1	2
Noni	1	2
Onion	2	2
P-Coumaric Acid	1	2
Paeoniflorin	1	2
Panax Ginseng	1	2
Panax Notoginseng	1	2
Papaya	1	2
Parsley	1	2
Pineapple	1	2
Plantain	1	2
Potato: Pigmented	1	2
Prebiotics	1	2
Raspberry ketone	1	2
Reishi Mushroom	1	2
Rice	1	2
Rice Bran	1	2
Rosemaric Acid	1	2
Rosemary	1	2
Rosmarinic acid	1	2
Salvia divinorum	1	2
Seaweed: Brown	1	2
Sessile Joyweed	1	2
Shark Cartilage	1	2
Shiitake Mushroom	1	2
Shikonin	1	2
Shilajit	1	2
Silymarin	1	2
Spearmint	1	2
Tart Cherry	1	2
Tongkat Ali	1	2
Toona sinensis	1	2
Tribulus	1	2
Ursolic Acid	1	2
Verbascoside	1	2
Virgin Coconut Oil	1	2
Vitamin B-12	1	2
Vitamin E: Gamma-tocotrienol	1	2
Vitex Agnus	1	2
Vitex negundo	1	2
Water: Deuterium Depleted	1	2
Watermelon	1	2
Wheat Grass	1	2
White Tea	1	2
Wild Lettuce	1	2
phytoestrogens	1	2
Andrographolide	1	1
Astragalus	1	1
Bacillus subtilis	1	1
Blackberry	1	1
Blueberry	1	1
Burdock	1	1
Caffeoylquinic Acids	1	1
Carpolobia lutea	1	1
Cloudberry	1	1
Elecampane	1	1
Evodia ruteacarpa	1	1
Fish	1	1
Fruit: All	1	1
Gallic Acid	1	1
Garcinia Mangostana	1	1
Gold	1	1
Honeydew (melon)	1	1
Honokiol	1	1
Isoliquiritigenin	1	1
Kratom	1	1
Lemongrass: Essential Oil	1	1
Lime	1	1
Maca	1	1
Magnolol	1	1
Mango Seed	1	1
Mangosteen	1	1
Marshmallow Root	1	1
Mosla scabra	1	1
Mung Bean	1	1
Nutmeg	1	1
Phenethyl isothiocyanate	1	1
Proprietary Nutrient Formulas	1	1
Psychedelics:All	1	1
Radix Isatidis	1	1
Raspberry	1	1
Resveratrol	1	1
Rhubarb	1	1
Salicylic acid	1	1
Sea buckthorn	1	1
Strawberry	1	1
Thymol	1	1
Vitexins	1	1
Willow Bark	1	1
Wine	1	1
Zinc	1	1
Blue-Green Algae	1	0

11 Therapeutic Actions Researched for Natural Substances Versus Drugs

Name	AC	CK
Homeopathic Treatment	5	42
Photobiomodulation	2	15
Acupressure	1	10
Acupuncture	1	10
Light Therapy	1	10
Massage/Therapeutic Touch	1	10
Moxibustion	1	10
Oil Pulling	1	10
Weight Reduction	1	10
Electroacupuncture	1	2
Exercise	1	2

140 Pharmacological Actions Researched for Natural Substances Versus Drugs

Name	AC	CK
Anti-Inflammatory Agents	81	269
Analgesics	37	251
Antidepressive Agents	32	212
Antimicrobial	23	147
Anti-Bacterial Agents	31	142
Antioxidants	58	133
Hypoglycemic Agents	34	96
Antiproliferative	36	70
Tumor Necrosis Factor (TNF) Alpha Inhibitor	21	69
Hypolipidemic	20	53
Antiviral Agents	15	52
Apoptotic	26	48
Neuroprotective Agents	21	47
Anti-Anxiety Agents	6	44
Antifungal Agents	8	40
Immunomodulatory	9	32
Anti-Ulcer Agents	11	30
Anticholesteremic Agents	8	30
Interleukin-6 Downregulation	9	30
anti-inflammatory	3	30
Prophylactic Agents	3	22
Anti-Platelet	2	20
Platelet Aggregation Inhibitors	2	20
Vasodilator Agents	2	20
Cardioprotective	5	17
Antihypertensive Agents	4	16
Osteoprotective	4	16
Gastroprotective	8	15
Hepatoprotective	8	15
Interleukin-1 beta downregulation	8	15
Malondialdehyde Down-regulation	7	14
NF-kappaB Inhibitor	9	14
Anticarcinogenic Agents	3	13
Antineoplastic Agents	7	13
Anti-Allergic Agents	2	12
Gastrointestinal Agents	2	12
Hypotensive	2	12
Anti-pyretic	2	11
Antiparasitic Agents	5	11
Cyclooxygenase 2 Inhibitors	7	11
Cyclooxygenase Inhibitors	2	11
Interleukin-8 downregulation	2	11
Adrenergic alpha-Antagonists	1	10
Anti-Androgen	1	10
Anti-collagenase	1	10
Antinoceceptive	5	10
Antioxidant	1	10
Cardiovascular Agents	1	10
Cytotoxic	6	10
Dermatologic Agents	1	10
Diuretics	1	10
Enzyme Inhibitors	1	10
Estrogens	1	10
Insulin Down-Regulation	1	10
Postaglandin PGE2 downregulation	1	10
Regenerative	1	10
Sedative effects	1	10
Uterotonic	1	10
Renoprotective	5	9
Superoxide Dismutase Up-regulation	5	9
Chemotherapeutic	5	7
Analgesics: Non-Narcotic	3	6
Angiogenesis Inhibitors	4	6
Anti-metastatic	4	6
Chemopreventive	5	6
Chemoprotective Agents	3	6
Nrf2 activation	3	6
Radioprotective	3	6
Insulin Sensitizers	3	5
Matrix metalloproteinase-9 (MMP-9) inhibitor	3	5
Acetylcholinesterase Inhibitor	2	4
Anti-Apoptotic	2	4
Antipsychotic Agents	2	4
Cell cycle arrest	3	4
Interleukin-10 downregulation	2	4
Leishmanicidal	3	4
Anticonvulsants	2	3
Antiprotozoal Agents	2	3
Calcium Channel Blockers	2	3
Matrix metalloproteinase-2 (MMP-2) inhibitor	2	3
Nitric Oxide Inhibitor	2	3
5-Lipoxygenase Inhibitor	1	2
Adrenergic alpha-Agonists	1	2
Alpha-amylase inhibitor	2	2
Alpha-glucosidase inhibitor	2	2
Anti-Angiogenic	1	2
Anti-Asthmatic Agents	1	2
Anti-Inflammatory Agents: Non-Steroidal	1	2
Anticoagulants	1	2
Antispasmodic	1	2
Anxiolytic	1	2
Brain-derived neurotrophic factor modulator	1	2
Bronchoconstrictor Agents	1	2
Caspase-3 Activation	2	2
Chemosensitizer	2	2
Cholinesterase Inhibitors	1	2
Cyclooxygenase 1 Inhibitor	1	2
Cytoprotective	1	2
Detoxifier	1	2
Heme oxygenase-1 up-regulation	1	2
Hypnotics and Sedatives	1	2
Interferon Gamma Reducer	1	2
Interleukin-10 upregulation	1	2
Interleukin-12 downregulation	1	2
Interleukin-2 upregulation	1	2
Interleukin-4 upregulation	1	2
Lipoxygenase Inhibitors	1	2
Neurogenesis	1	2
Nootropic Agents	1	2
Pancreato Protective Agents	1	2
Proton Pump Inhibitor	1	2
Radiosensitizer	1	2
Schistosomicides	1	2
Tumor Suppressor Protein p53 Upregulation	2	2
Vascular Endothelial Growth Factor A Inhibitor	1	2
Wnt/β-catenin pathway down-regulation	1	2
apoptosis	1	2
AMP-activated protein kinase modulation	1	1
Anti-Glycation Agents	1	1
Anti-HIV Agents	1	1
Antidiarrheals	1	1
Antigiardial agents	1	1
Caspase-8 activation	1	1
Catalase Up-Regulation	1	1
Cyclin D1 Down-Regulation	1	1
Gluconeogenesis Inhibitor	1	1
Heat Shock Protein Down-Regulation	1	1
Histone deacetylase inhibitor	1	1
Insulin-releasing	1	1
Lactate Dehydrogenase A Inhibitor	1	1
MicroRNA modulator	1	1
Neurominidase Inhibitor	1	1
P21 Activation	1	1
Prostaglandin PGE2 downregulation	1	1
Reverse Transcriptase Inhibitors	1	1
SIRT1 Activator	1	1
Telomerase Inhibitor	1	1
Vascular Cell Adhesion Molecule-1 Inhibitor	1	1
Vascular Endothelial Growth Factor Inhibitors	1	1
Viral Hemagglutinin Inhibitor	1	1

Research Articles 557
Cumulative Knowledge Score 901
Overall Research Rating EXCELLENT

View the Evidence:
557 Abstracts with Natural Substances Versus Drugs Research

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View the Evidence: 557 Abstracts with Natural Substances Versus Drugs Research

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A systematic review of the literature showed that Permixon was effective for relieving urinary symptoms due to prostate enlargement.Nov 30, 2016

Evening primrose oil is a safe medication with similar efficacy for pain control in women with mastalgia to topical NSAIDS, danazol, or vitamin E.Jun 09, 2021

Ginkgo biloba, chamomile and kava kava exhibit therapeutic potential in generalizaed anxiety disorder.Oct 15, 2010

Saffron was effective in the treatment of major depressive disorder and had comparable efficacy to synthetic antidepressants.Dec 31, 2017

The findings of this study showed that saffron administration was well comparable with fluoxetine and placebo.Dec 31, 2018

The results confirm the efficacy of the three herbal active substances in elderly patients with anxiety, depression, and dementia.Jun 19, 2015

Topical mother's milk may provide an effective alternative to topical antibiotics in infant epiphora. Feb 01, 2007

Zingiberaceae extracts are clinically effective hypoalgesic agents and the available data show a better safety profile than non steroidal anti inflammatory drugs.Dec 31, 2014

The intraluminal administration of peppermint oil by using a hand pump is a simple, safe, and convenient alternative to the systemic injection of a cholinergic blocking agent or glucagon during colonoscopy.Feb 01, 2001

2% dill vaginal suppositories were as effective as 100 mg clotrimazole vaginal tablets in reducing both the clinical and microbiological symptoms.Mar 18, 2018

A combination of baicalin (a compound found within Chinese skullcap) and catechin (a polyphenol plant antioxidant) are as effective as naproxen in treating osteoarthritis of the knee. Dec 01, 1985

A combination of garlic, mullein, calendula, st. johns wort and olive oil is as effective as an anesthetic drug for the management of acute otitis media-associated pain. Jul 01, 2001

A combination of nasturtium herb and horseradish root is as effetive in treating acute sinusitis, acute bronchitis and acute urinary tract infections as comparable to treatment with standard antibiotics. Jan 01, 2006

A Comparative study on the efficacy of coenzyme Q10 and amitriptyline in the prophylactic treatment of migraine headaches.Dec 31, 2021

A diet high in plant sterols, vegetable proteins, viscous fibers and almonds is as effective as the statin drug lovastatin in managing hypercholesterolemia. Jul 23, 2003

A homeopathic combination (Vertigoheel) reduced the frequency, duration, and intensity of vertigo attacks and compared favorably to the drug betahistine hydrochloride. Aug 01, 1998

A homeopathic gel compares favorably to NSAID gel for treating osteoarthritis of the knee.Jul 01, 2000

A homeopathic ointment preparation compares favorably with 1% diclofenac gel for acute symptomatic treatment of tendinopathy.Nov 01, 2005

A horsetail extract produced a diuretic effect that was stronger than that of the negative control and was equivalent to that of hydrochlorothiazide.Dec 31, 2013

A randomized, double-blind, split-face study of topical silymarin vs 2% hydroquinone cream in melasmas.Nov 30, 2022

A standardized preparation of curcuminoids compares favorably with atorvastatin on endothelial dysfunction in association with reductions in inflammatory cytokines and markers of oxidative stress. Jan 01, 2008

Acupuncture is as effective as low-dose prednisolone for mild-to-moderate carpal tunnel syndrome. May 01, 2009

Administration of olive oil followed by a low volume of polyethylene glycol-electrolyte lavage solution improves patient satisfaction with right-side colonic cleansing over conventional preparation. Sep 01, 2009

Administration of saffron capsules was comparable with memantine in reducing cognitive decline in patients with moderate to severe AD.Jun 30, 2014

Aloe vera and tea tree oil mouthwashes can decrease plaque, gingivitis and S. mutans in the oral cavity in children.May 19, 2019

Aloe vera gel has been shown to be as effective as benzyl benzoate in the treatment of scabies. Mar 09, 2009

Aloe vera may prove an effective mouthwash due to its ability in reducing dental plaque.Mar 31, 2014

Aloe vera mouthwash has comparable antiplaque efficacy as the gold standard 0.2% chlorhexidine gluconate with fewer side effects.Apr 30, 2016

Aloe vera mouthwash was as beneficial as benzydamine mouthwash in alleviating the severity of radiation-induced mucositis.Dec 31, 2014

An extract of saw palmetto compares favorably with the drug tamsulosin in the treatment of benign prostatic hyperplasia. Jun 01, 2002

An herbal extract combination (Biochanin A, Acetyl tetrapeptide-3, and ginseng extracts) versus 3% minoxidil solution for the treatment of androgenetic alopecia.Sep 30, 2020

Arnica is superior to steroids for reducing adverse effects, e.g. bruising, from rhinoplastic surgery. Jul 01, 2007

Arnica montana is efficacious in healing wound associated with Hallux valgus (bunion) surgery. Jan 01, 2008

Berberine is a potent oral hypoglycemic agent with benefical effects on lipid metabolism, comparable in efficacy to metformin. May 01, 2008

Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.Oct 06, 2009

Bioavailable turmeric extract is as effective as paracetamol in reducing pain and other symptoms of knee osteoarthritis.Jan 29, 2021

Black chokeberry juice lowered the incidence of Urinary tract infections by 55% and a reduction in antibiotics use in patients. May 31, 2014

Black cohosh compares favorably to fluoxetine in the treatment of postmenopausal symptoms.Feb 28, 2007

Black cumin possesses clinical useful anti-H. pylori activity compared to triple therapy.Jul 01, 2010

Both hyaluronic acid vaginal gel and estriol cream can significantly improve the clinical symptoms of vaginal dryness in postmenopausal women, with improvement rate of 84.44% and 89.42%, respectively, after 10 applications, without statistically significaMay 31, 2013

Bright light treatment, both as monotherapy and in combination with fluoxetine, was efficacious and well tolerated in the treatment of adults with nonseasonal Nonseasonal Major Depressive Disorder.Dec 31, 2015

Butterbur is as effective as fexofenadine in attenuating nasal symptoms in patients with perennial allergic rhinitis. Apr 01, 2004

Cabbage leaf application and cooling gel pad application showed similar improvements in reducing osteoarthritis symptoms.Dec 31, 2021

Caffeine compares favorably to amphetamine in reducing the symptoms of treatment-resistant obsessive-compulsive disorder.Nov 01, 2009

Caffeine is as effective as aminophylline, while it is superior to aminophylline regarding its overall safety.Dec 31, 2017

Castor oil is safe and effective in the treatment of patients wtih osteoarthritis. Oct 01, 2009

Celadrin, a proprietary formula containing Cetyl Myristoleate, improves knee function in patients with osteoarthritisAug 01, 2002

Chamomile extract produced a clinically meaningful reduction in generalized anxiety disorder symptoms over 8 weeks.Dec 14, 2016

Chamomile extract reduced biofilm accumulation and gingival bleeding in patients with gingivitis.Dec 31, 2015

Chamomile is as effective as clotrimazole in vulvovaginal candidiasis treatment.Dec 30, 2021

Cinnamon as compared significantly reduces the severity and duration of pain during menstruation, but this effect is less compared to that of Ibuprofen.Mar 31, 2015

Clove is as effective as benzocaine as a topical anesthesic.Nov 01, 2006

Coconut oil gargling is as effective as using chlorhexidine mouthwash for the reduction of S. mutans.Aug 31, 2016

Comparable efficacy of standardized Ayurveda formulation and hydroxychloroquine sulfate (HCQS) in the treatment of rheumatoid arthritis (RA).Jan 31, 2012

Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.Jan 31, 2013

Comparison of the effect of melatonin, dexmedetomidine, and gabapentin on reduction of postoperative pain and anxiety following laminectomy.Oct 14, 2022

Consumption of rose oil soft capsule alleviates cardinal GERD symptoms similar to omeprazole.Apr 30, 2021

Continual intake of a probiotic drink containing Lactobacillus brevis led to a reduction in the incidence of influenza, especially in subjects not inoculated with influenza vaccine.Nov 30, 2014

Cranberry compares favorably to the drug trimethoprim in the prevention of recurrent urinary tract infections in older women, without increasing the risk of antibiotic resistance/super-infection and/or fungal infection. Feb 01, 2009

Crocin is effective in treatment of patients with mild to moderate OCD with possibly fewer adverse effects compared to fluoxetine.Feb 17, 2021

Crocus sativus compares favorably in the treatment of mild to moderate depression. Feb 27, 2005

Curcuma longa Linn can improve dyspeptic symptoms, improve quality of life, and provide satisfaction equivalent to omeprazole.Oct 14, 2021

Curcumin compares favorably with corticosteroid therapy in the management of chronic anterior uveitis.Jun 01, 1999

Curcumin is comparable to chlorhexidine as an anti-inflammatory mouthwash. Thus, it can be considered as an effective adjunct to mechanical periodontal therapy.Dec 31, 2012

Curcumin is safe and efficacious in treating major depressive disorder.Jul 05, 2013

Cyclic antibiotic therapy in combination with fiber for diverticular disease results in very little benefit in comparison to fiber alone.Sep 01, 2010

Dietary flaxseed lignan improves lower urinary tract symptoms in benign prostatic hyperplasia subjects as well as drug therapy. Jan 01, 2007

Dietary soy supplementation constitutes an effective alternative therapy for somatic and urogenital symptoms of the menopause.Nov 01, 2010

Dill might be beneficial for hypercholesterolemic and hypertriglycemic patients.Jul 31, 2014

Dill was as effective as mefenamic acid in reducing the pain severity in primary dysmenorrhea.Mar 31, 2014

Echinacea/sage is at least as effective as chlorhexidine/lidocaine for treating acute sore throats. Sep 01, 2009

Effectiveness of Bromelain in the control of postoperative pain after periodontal surgery.Dec 31, 2022

Natural Substances Versus Drugs

View the Evidence:
557 Abstracts with Natural Substances Versus Drugs Research