Pumpkin Seeds

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6 Diseases Researched for Pumpkin Seeds
NameACCKFocus
Inflammation110Locked
Kidney Failure110Locked
Breast Cancer11Locked
Colon Cancer11Locked
Prostate Cancer11Locked
Prostatic Hyperplasia: Benign11Locked
4 Substances Researched for Pumpkin Seeds
NameACCKFocus
Pumpkin Seeds211Locked
Flaxseed110Locked
Sesame Seeds110Locked
Pumpkin11Locked
5 Pharmacological Actions Researched for Pumpkin Seeds
NameACCKFocus
Anti Inflammatory110Locked
Hypoglycemic Agents110Locked
Interleukin-6 Downregulation110Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor110Locked
Antiproliferative 11Locked

View the Evidence:
42 Abstracts with Pumpkin Seeds Research

[+]

A dietary mixture of sesame, pumpkin and flax seed added to a habitual diet lowered triglyceride and CRP, TNF-alpha, IL-6 levelsDec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ScientificWorldJournal. 2014 ;2014:563576. Epub 2014 Jan 22. PMID: 24578648
Article Published Date : Dec 31, 2013
Study Type : Human Study
Additional Links
Substances : Flaxseed, Pumpkin Seeds, Sesame Seeds
Diseases : Inflammation, Kidney Failure
Pharmacological Actions : Anti Inflammatory, Hypoglycemic Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Supplementation
[+]

A mix of pumkin Seed, horsetail and flax is highly effective on stress urinary incontinence.Mar 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Tradit Complement Med. 2019 Apr ;9(2):138-142. Epub 2018 May 3. PMID: 30963048
Article Published Date : Mar 31, 2019
Study Type : Human Study
Additional Links
Substances : Flaxseed, Horsetail, Pumpkin Seeds
Diseases : Incontinence: Urinary
Additional Keywords : Significant Treatment Outcome
[+]

Oil-free hydroethanolic pumpkin seed extract could be beneficial for benign prostatic hyperplasia related symptoms.May 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Food. 2019 Jun ;22(6):551-559. Epub 2019 Apr 24. PMID: 31017505
Article Published Date : May 31, 2019
Study Type : Human Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Prostatic Hyperplasia: Benign
Additional Keywords : Plant Extracts
[+]

Pumpkin seed oil relieved benign prostatic hyperplasia symptoms with no side effectsOct 18, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Urol. 2021 Oct 19 ;21(1):147. Epub 2021 Oct 19. PMID: 34666728
Article Published Date : Oct 18, 2021
Study Type : Human Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Prostatic Hyperplasia: Benign
Additional Keywords : Natural Substances Versus Drugs
[+]

Pumpkin seed has potential as a hypoglycemic food.Jul 31, 2018

Pubmed Data : Nutr Res. 2018 Aug ;56:90-97. Epub 2018 Apr 26. PMID: 30055778
Article Published Date : Jul 31, 2018
Study Type : Human Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Hyperglycemia
Pharmacological Actions : Hypoglycemic Agents
[+]

Pumpkin seed oil improved arterial hemodynamics in postmenopausal women.Aug 07, 2019

Pubmed Data : Complement Ther Clin Pract. 2019 Aug 8 ;37:23-26. Epub 2019 Aug 8. PMID: 31445363
Article Published Date : Aug 07, 2019
Study Type : Human Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Hypertension, Postmenopausal Disorders
Pharmacological Actions : Antihypertensive Agents
[+]

The relationship between seeds consumption, lipid profile and body mass index among patients with cardiovascular diseases.Dec 31, 2020

Pubmed Data : Rocz Panstw Zakl Hig. 2021 ;72(2):145-153. PMID: 34114771
Article Published Date : Dec 31, 2020
Study Type : Human Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Cardiovascular Diseases
Pharmacological Actions : Cardioprotective, Hypolipidemic
[+]

Treatment with pumpkin seed led to a clinically relevant reduction in international prostate symptom score compared with placebo.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Urol Int. 2015 ;94(3):286-95. Epub 2014 Sep 5. PMID: 25196580
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Prostatic Hyperplasia
Additional Keywords : Plant Extracts
[+]

A diet rich in saturated fat to a diet rich in unsaturated fat can attenuate NAFLD and atherosclerosis development.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(9):e0139196. Epub 2015 Sep 25. PMID: 26405765
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Atherosclerosis, Dyslipidemias, Inflammation, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective
[+]

Amelioration of related complications by the combined usage of Gymnadenia orchidis Lindl and pumpkin seed in type 2 diabetes.Dec 08, 2021

Pubmed Data : J Complement Integr Med. 2021 Dec 9. Epub 2021 Dec 9. PMID: 34883006
Article Published Date : Dec 08, 2021
Study Type : Animal Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ameliorative effect of pumpkin seed oil against emamectin induced toxicity in mice.Jan 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Feb ;98:242-251. Epub 2017 Dec 27. PMID: 29268245
Article Published Date : Jan 31, 2018
Study Type : Animal Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Pesticide Toxicity
Pharmacological Actions : Hepatoprotective, Renoprotective
Problem Substances : Pesticides
[+]

Antiparkinsonian activity of Cucurbita pepo seeds along with possible underlying mechanism.Mar 23, 2021

Pubmed Data : Metab Brain Dis. 2021 Mar 24. Epub 2021 Mar 24. PMID: 33759084
Article Published Date : Mar 23, 2021
Study Type : Animal Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Combined extracts of pumpkin seed and ginger might be used as a protective agent against cyclophosphamide induced reproductive toxicity.Aug 31, 2016

Pubmed Data : Anat Sci Int. 2016 Sep ;91(4):382-90. Epub 2015 Dec 29. PMID: 26714700
Article Published Date : Aug 31, 2016
Study Type : Animal Study
Additional Links
Substances : Ginger, Pumpkin Seeds
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Chemoprotective Agents
Additional Keywords : Plant Extracts
[+]

Cucurbita maxima seed oil may exert antiamnesic activity which may be attributed to the inhibition of AChE and inflammation.Aug 31, 2014

Pubmed Data : Z Naturforsch C. 2014 Sep-Oct;69(9-10):407-17. PMID: 25711042
Article Published Date : Aug 31, 2014
Study Type : Animal Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Amnesia, Inflammation, Oxidative Stress
Pharmacological Actions : Acetylcholinesterase Inhibitor, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Natural Substances Versus Drugs, Plant Extracts
[+]

Cucurbita maxima seeds oil might ameliorate high fat diet-induced obesity.Jun 30, 2019

Pubmed Data : Arch Physiol Biochem. 2019 Jul ;125(3):228-234. Epub 2018 Mar 19. PMID: 29553847
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Inflammation, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Hypolipidemic, Interleukin-6 Downregulation, MicroRNA modulator, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Anti-Obesity Agents
[+]

Cucurbita pepo L. effectively ameliorated the chronic stress-induced behavioral, biochemical, and adrenal structural changes.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:749766. Epub 2021 Nov 10. PMID: 34867356
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Depression
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Antioxidants, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Fluted pumpkin seeds protect against busulfan-induced oxidative stress and testicular injuries.Aug 29, 2019

Pubmed Data : Drug Chem Toxicol. 2019 Aug 30:1-11. Epub 2019 Aug 30. PMID: 31469002
Article Published Date : Aug 29, 2019
Study Type : Animal Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Chemotherapy and Radiation Toxicity, Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Antioxidants, Chemoprotective Agents
[+]

Pumpkin seed extract might be used as protective agent against cyclophosphamide induced reproductive toxicity.Sep 30, 2014

Pubmed Data : Andrologia. 2014 Oct ;46(8):927-35. Epub 2013 Oct 11. PMID: 24124763
Article Published Date : Sep 30, 2014
Study Type : Animal Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Chemoprotective Agents
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Pumpkin seed extracts may be used to control of gastrointestinal nematode infections.Aug 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 Sep 1 ;17(9). Epub 2016 Sep 1. PMID: 27598135
Article Published Date : Aug 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Parasitic Diseases
Pharmacological Actions : Antiparasitic Agents
Additional Keywords : Plant Extracts
[+]

Pumpkin seed has beneficial effects in atherogenic animals by reducing in serum concentrations of TC and LDL-C and increasing levels of HDL-C.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Afr J Tradit Complement Altern Med. 2012 ;9(1):131-7. Epub 2011 Oct 2. PMID: 23983330
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Atherosclerosis
Pharmacological Actions : Anti-atherogenic, Anticholesteremic Agents, Hepatoprotective, Hypolipidemic
Additional Keywords : Phytotherapy
[+]

Pumpkin seed oil alleviates oxidative stress and liver damage induced by sodium nitrate.Feb 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Afr Health Sci. 2020 Mar ;20(1):413-425. PMID: 33402930
Article Published Date : Feb 29, 2020
Study Type : Animal Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
Problem Substances : Sodium Nitrate
[+]

Pumpkin seed oil has a protective effect against HCL aspiration lung injury most probably through its antioxidant activity.Feb 28, 2017

Pubmed Data : Acta Histochem. 2017 Mar ;119(2):161-171. Epub 2017 Jan 22. PMID: 28122663
Article Published Date : Feb 28, 2017
Study Type : Animal Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Lung Injury: Acute, Pneumonia
Pharmacological Actions : Antioxidants, Cytoprotective
Additional Keywords : Plant Extracts
[+]

Pumpkin seed oil prevents the high fat diet induced obesity by altering the markers important to lipid metabolism.Oct 18, 2017

Pubmed Data : Nat Prod Res. 2017 Oct 19:1-4. Epub 2017 Oct 19. PMID: 29047298
Article Published Date : Oct 18, 2017
Study Type : Animal Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents
[+]

Pumpkin seed oil rats showed alleviated endoplasmic reticulum stress accompanied by lowered unfolded protein response.Feb 28, 2017

Pubmed Data : J Sci Food Agric. 2017 Mar ;97(4):1158-1163. Epub 2016 Jul 1. PMID: 27293203
Article Published Date : Feb 28, 2017
Study Type : Animal Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Metabolic Diseases
Pharmacological Actions : Antioxidants
[+]

Pumpkin seeds protect against formaldehyde-induced major organ damages.Jul 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2020 Aug ;6(8):e04587. Epub 2020 Aug 20. PMID: 32904241
Article Published Date : Jul 31, 2020
Study Type : Animal Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Formaldehyde Toxicity
Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective
Problem Substances : Formaldehyde
[+]

The administration of pumpkin seed oil diminished aflatoxin-induced adverse effectsNov 30, 2013

Pubmed Data : Environ Toxicol. 2013 Dec ;28(12):681-8. Epub 2011 Aug 31. PMID: 24591108
Article Published Date : Nov 30, 2013
Study Type : Animal Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
Problem Substances : Aflatoxin
[+]

The potentials of the pumpkin seeds to manage erectile dysfunction was recommended.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biochem Biophys Rep. 2017 Dec ;12:5-11. Epub 2017 Aug 16. PMID: 28955786
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Erectile Dysfunction
Pharmacological Actions : Enzyme Inhibitors
[+]

The results obtained from this preclinical study indicated that the sunscreen formulation is non toxic and safe in animal models.Sep 30, 2017

Pubmed Data : Regul Toxicol Pharmacol. 2017 Oct ;89:1-12. Epub 2017 Jul 8. PMID: 28694170
Article Published Date : Sep 30, 2017
Study Type : Animal Study
Additional Links
Substances : Melatonin, Pumpkin Seeds
Diseases : Ultraviolet Radiation Induced Damage
Pharmacological Actions : Photoprotective
Additional Keywords : Sunscreen
[+]

The root Salep and pumpkin seed synergistically prevent diabetic complications and could be better supplementation against type-2 diabetes.Nov 30, 2018

Pubmed Data : Diabetes Res Clin Pract. 2018 Dec ;146:278-288. Epub 2018 Nov 10. PMID: 30423348
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective
Additional Keywords : Natural Substance Synergy
[+]

The seed extracts of C. maxima and C. sativus extracts were almost comparable to aspirin and brufen.Jul 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2021 Aug ;28(8):4334-4341. Epub 2021 Apr 17. PMID: 34354417
Article Published Date : Jul 31, 2021
Study Type : Animal Study
Additional Links
Substances : Cucumber, Pumpkin Seeds
Diseases : Chronic Pain, Inflammation
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents
Additional Keywords : Natural Substances Versus Drugs
[+]

These findings showed that the selected Cucurbitaceae seeds contained globulins with significant anti-hyperglycaemic activity.Mar 17, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2013 Mar 18 ;13:63. Epub 2013 Mar 18. PMID: 23506532
Article Published Date : Mar 17, 2013
Study Type : Animal Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Hyperglycemia
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Plant Extracts
[+]

These results provide pharmacological evidence of pumpkin seed extract as a botanical antihyperglycemic agent. Oct 31, 2013

Pubmed Data : J Formos Med Assoc. 2013 Nov ;112(11):676-90. PMID: 24344360
Article Published Date : Oct 31, 2013
Study Type : Animal Study
Additional Links
Substances : Pumpkin Seeds, Vitamin E
Diseases : Diabetes Mellitus: Type 2, Oxidative Stress
Pharmacological Actions : Antioxidants, Hypoglycemic Agents
Additional Keywords : Phytotherapy, Plant Extracts
[+]

This study has given for the first time scientific evidence of the healing efficiency of pumpkin and linseed oils on burn-wounds.Dec 31, 2015

Pubmed Data : Pharm Biol. 2016 ;54(4):581-7. Epub 2015 Jul 17. PMID: 26186459
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Flaxseed, Pumpkin Seeds
Diseases : Burns, Wound Healing
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A carotenoid extract from a cultivar of pumpkin triggers nonprotective autophagy in malignant cells.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2017 ;2017:7468538. Epub 2017 Dec 21. PMID: 29430284
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Colon Cancer, Osteosarcoma
Pharmacological Actions : Antiproliferative , Autophagy Up-regulation
[+]

A review of edible seeds from Cucurbitaceae family as potential functional foods.Jun 30, 2017

Pubmed Data : Biomed Pharmacother. 2017 Jul ;91:330-337. Epub 2017 May 2. PMID: 28463796
Article Published Date : Jun 30, 2017
Study Type : Review
Additional Links
Substances : Pumpkin Seeds
Diseases : Cancers: All, Hypertension, Oxidative Stress
Pharmacological Actions : Antihypertensive Agents, Antioxidants, Cardioprotective, Genoprotective, Hypoglycemic Agents
[+]

Biochemical proximates of pumpkin and their beneficial effects on the general well-being of poultry species.Feb 02, 2017

Pubmed Data : J Anim Physiol Anim Nutr (Berl). 2017 Feb 3. Epub 2017 Feb 3. PMID: 28158900
Article Published Date : Feb 02, 2017
Study Type : Review
Additional Links
Substances : Pumpkin Seeds
Pharmacological Actions : Anti-Inflammatory Agents, Antifungal Agents, Antimicrobial, Antiparasitic Agents, Immunomodulatory
[+]

Preliminary investigation showed that pumpkin seeds possess hypoglycemic properties and could assist in maintaining glycemic control.Dec 31, 2013

Pubmed Data : Crit Rev Food Sci Nutr. 2014 ;54(10):1322-9. PMID: 24564589
Article Published Date : Dec 31, 2013
Study Type : Review
Additional Links
Substances : Pumpkin Seeds, Trigonelline
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents
[+]

Pumpkin seed extract had growth inhibition effects on hyperplastic and some cancer cell lines. Mar 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Fitoterapia. 2016 Apr ;110:150-6. Epub 2016 Mar 11. PMID: 26976217
Article Published Date : Mar 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Pumpkin, Pumpkin Seeds
Diseases : Breast Cancer, Colon Cancer, Prostate Cancer, Prostatic Hyperplasia: Benign
Pharmacological Actions : Antiproliferative
Additional Keywords : Plant Extracts
[+]

Pumpkin seed extracts inhibit proliferation and induce autophagy in PC-3 androgen insensitive prostate cancer cells.May 10, 2021

Pubmed Data : J Med Food. 2021 May 11. Epub 2021 May 11. PMID: 33978471
Article Published Date : May 10, 2021
Study Type : In Vitro Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Cancer: Prostate
Pharmacological Actions : Antiproliferative , Autophagy Up-regulation
[+]

Pumpkin seed's lignans could have a potential role in breast cancer prevention and treatment.Dec 31, 2012

Pubmed Data : Nutr Cancer. 2013 ;65(5):739-45. PMID: 23859042
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Chemopreventive, Estrogen Receptor Modulators
Additional Keywords : Estrogen Receptor Beta, Plant Extracts
[+]

Seeds from ancient food crops with the potential for antiobesity promotion.Jan 27, 2021

Pubmed Data : Crit Rev Food Sci Nutr. 2021 Jan 28:1-8. Epub 2021 Jan 28. PMID: 33506693
Article Published Date : Jan 27, 2021
Study Type : Review
Additional Links
Substances : Chia, Flaxseed, Nigella sativa (aka Black Seed), Pumpkin Seeds, Sesame Seeds, Sunflower Seeds
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents
[+]

The current study highlight the anti-inflammatory property of pumpkin, linseed, and prickly pear oils on carrageenan-induced acute inflammation.Dec 31, 2019

Pubmed Data : Biomed Res Int. 2020 ;2020:5643465. Epub 2020 Aug 2. PMID: 32802857
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Prickly Pear Cactus, Pumpkin Seeds
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

Copyright: alexraths / 123RF Stock Photo

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