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Risk Reduction
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40 Problem Substances Researched for Risk Reduction
Name
AC
CK
Focus
Sugar Sweetened Beverages
6
70
Infant Formula
5
23
Insulin
2
20
Pesticides
2
20
Sugary soda
2
20
Bisphenol A
4
15
Antipsychotic Drugs
3
14
Tamoxifen
2
12
Aromatase Inhibitors
2
11
Alcohol Consumption
1
10
Casein
1
10
Casein: A1
1
10
Cow Milk
1
10
Meat
1
10
Olanzapine
1
10
Organophosphate Pesticides
1
10
Oseltamivir (trade name Tamiflu)
1
10
Paclitaxel
1
10
Phthalates
1
10
Proton-Pump Inhibitors
1
10
Statin Drugs
1
10
Sucrose
1
10
Tobacco: Smoking
1
10
High Fructose Corn Syrup
4
7
Isoproterenol
2
3
Acrylamide
1
2
Alloxan
1
2
Aluminum Chloride
1
2
Antibiotics
1
2
Cypermethrin
1
2
Fluoxetine (trade name Prozac)
2
2
Hydrogenated Palm Oil
1
2
Lead
1
2
Methylphenidate
1
2
Artificial Sweeteners
1
1
Cadmium
1
1
Ethanol
1
1
Fluoroquinolone Antibiotic
1
1
Meat: Cooked
1
1
Triclosan
1
1
520 Diseases Researched for Risk Reduction
Name
AC
CK
Focus
Cardiovascular Diseases
178
1559
Cardiac Mortality
59
713
Diabetes Mellitus: Type 2
98
692
All-Cause Mortality
57
665
Diabetes Mellitus: Type 2: Prevention
75
651
Breast Cancer
70
648
Vitamin D Deficiency
61
608
Hypertension
60
588
Obesity
81
526
Depression
48
415
Coronary Artery Disease
34
386
Stroke
32
345
Metabolic Syndrome X
37
343
Inflammation
55
341
Cardiovascular Disease: Prevention
33
326
Cognitive Decline/Dysfunction
37
291
Insulin Resistance
43
290
Colorectal Cancer
27
286
Cancer Mortality
20
281
Cancers: All
32
271
Prostate Cancer
24
245
Dementia
29
236
Myocardial Infarction
27
231
Pancreatic Cancer
18
224
Esophageal Cancer
20
222
Alzheimer's Disease
44
220
Lung Cancer
19
215
Metabolic Diseases
29
209
Aging
23
199
Asthma
20
189
Gastric Cancer
18
188
Sepsis
18
184
Nonalcoholic fatty liver disease (NAFLD)
29
178
Liver Cancer
18
170
Prediabetes
20
166
Heart Failure
15
155
Magnesium Deficiency
13
151
Lung Cancer: Prevention
11
150
C-Reactive Protein
15
146
Endometrial Cancer
12
143
Mortality: All-Cause
14
141
Atherosclerosis
26
139
Oxidative Stress
32
137
Overweight
14
132
Prostate Cancer: Prevention
11
131
Gestational Diabetes
18
128
Breast Cancer: Prevention
12
120
Osteoporosis
14
120
Oral Cancer
10
115
Upper Respiratory Infections
12
113
Bone Fractures
11
112
Colorectal Cancer: Prevention
10
112
Smoking
12
112
Bladder Cancer
8
110
Coronavirus Infection
19
109
Endothelial Dysfunction
15
107
Pneumonia
14
106
Liver Cancer: Prevention
7
104
Ovarian Cancer
9
100
Cataract
11
96
Hypercholesterolemia
15
95
Influenza
13
90
Stroke: Ischemic
8
90
Colon Cancer
12
87
Respiratory Tract Infections
9
82
Macular Degeneration
9
81
Non-Hodgkin Lymphoma
7
81
Sitting Sickness
9
81
Peripheral Arterial Disease
8
80
Depressive Disorder
8
72
Chronic Kidney Disease (CKD)
7
71
Chronic Obstructive Pulmonary Disease
7
71
Gastric Cancer: Prevention
4
70
Heart Disease: Ischemic
4
70
Hyperlipidemia
11
69
Inflammatory Bowel Diseases
8
68
Parkinson's Disease
12
68
Multiple Sclerosis
11
66
Chronic Disease
9
65
Cardiovascular Disease
8
64
Preterm Birth: Prevention
6
62
Common Cold
7
61
Helicobacter Pylori Infection
5
61
Allergies
6
60
Gallstones
5
60
Head and Neck Cancer
6
60
Heart Disease
4
60
Hemodialysis
5
60
High Cholesterol
5
60
Hip Fracture
5
60
Lower Respiratory Infections
6
60
Peripheral Vascular Diseases
6
60
DNA damage
7
53
Infants: Low Birth Weight
7
53
Diabetes Mellitus: Type 1
11
52
Polycystic Ovary Syndrome
5
52
Postnatal Care: Breastfeeding
7
52
Alcohol Toxicity
5
51
Myocardial Infarction: Prevention
5
51
Atrial Fibrillation
3
50
Liver Cirrhosis
3
50
Liver Fibrosis
3
50
Necrotising enterocolitis
5
50
Oral Cancer: Prevention
3
50
Aging: Brain
6
44
Anxiety
6
44
Pregnancy Complications
6
44
Chemotherapy and Radiation Toxicity
5
43
Allergic Rhinitis
5
41
Colon Cancer: Prevention
5
41
Melanoma
4
41
Mood Disorders
4
41
Arteriosclerosis
4
40
Barrett Esophagus
3
40
Bladder Cancer: Prevention
2
40
Cholangiocarcinoma
4
40
High Fat Diet
20
40
Malignant Melanoma
3
40
Stroke: Hemorrhagic
3
40
Stroke: Prevention
4
40
Urinary Tract Infections
4
40
Dyslipidemias
9
39
Vitamin C Deficiency
6
39
Fatty Liver
7
38
Stroke: Attenuation/Recovery
8
37
Triglycerides: Elevated
5
34
Epstein-Barr Virus Infections
5
33
Asthma: Prevention
3
32
Diverticular Disease
4
31
Glioma
3
31
Headache: Migraine
4
31
Respiratory Diseases
4
31
Respiratory Tract Infections: Prevention
4
31
Septic Shock
4
31
Air Pollution Linked Toxicity
6
30
Arterial Hardening: Elasticity
3
30
Birth: Labor & Delivery
2
30
Brain Cancer
2
30
COPD
3
30
Cardiac Surgery
2
30
Cervical Neoplasia
2
30
Cesarean Section
2
30
Clostridium Infections
3
30
Depression
3
30
Diverticulitis
3
30
Elderly: Age Specific Diseases
2
30
Infant Infections
3
30
Kidney Cancer
3
30
Liver Diseases
2
30
Muscle Damage: Exercise-Induced
3
30
Myocardial Ischemia
2
30
Osteopenia
2
30
Postpartum Depression
3
30
Premature Birth
3
30
Hyperglycemia
6
27
Prenatal Nutrition: Health of the Offspring
5
25
Respiratory Infections
6
25
Osteoarthritis
3
24
Organ Transplantation: Liver
3
23
Periodontal Diseases
5
23
Pre-Eclampsia
4
23
Ulcerative Colitis
4
23
Depression: Postpartum
4
22
Diarrhea
3
22
Fractures: Bone
2
22
Liver Steatosis
2
22
Pesticide Toxicity
3
22
Psychiatric Disorders
3
22
Breast Cancer: Triple Negative
3
21
Delirium
2
21
Diabetic Retinopathy
3
21
Endothelial Damage
2
21
Infant Problems
3
21
Omega-3 Fatty Acid Deficiency
3
21
Rheumatoid Arthritis
3
21
Skin Cancer: Non-Melanoma
3
21
Acute Respiratory Distress Syndrome
1
20
African-American Specific Deficiencies/Diseases
2
20
Anemia
2
20
Atopic Dermatitis
2
20
Atopic Dermatitis: Infant & Childhood
2
20
Basal Cell Carcinoma
1
20
Bronchitis
1
20
Cardiac Arrhythmias
1
20
Cerebral Palsy
1
20
Child Mortality
1
20
Childhood Cognitive Disorders
2
20
Cholesterol: Oxidation
2
20
Cold: Common
2
20
Congenital Defects
1
20
Dengue
2
20
Diabetes: Gestational
2
20
Diarrhea: Antibiotic-Associated
1
20
Digestive System Cancer
1
20
Digestive System Neoplasms
1
20
Diverticulosis
2
20
Fibromyalgia
2
20
Food Allergies
2
20
Gastroesophageal Reflux
2
20
HDL: Low
2
20
Headache
2
20
Hepatitis C
2
20
High Homocysteine
2
20
Hyperthyroidism
2
20
Infant Mortality
1
20
Ischemic Disorders
1
20
Kaschin-Beck disease
2
20
Kidney Cancer: Prevention
1
20
Left Ventricular Dysfunction
2
20
Lymphoma
2
20
Mineral Deficiencies: Selenium
2
20
Neonatal Diseases and Abnormalities
2
20
Osteoporosis: Age-Related
1
20
Postmenopausal Complications
1
20
Postoperative Recovery
1
20
Rectal Cancer
2
20
Retinoblastoma
2
20
Spina Bifida
2
20
Thyroid Cancer
2
20
Vitamin B Deficiency
2
20
Wheezing: Infants
2
20
Diabetic Complications
6
19
Lipid Peroxidation
6
19
Diabetes Mellitus: Type 1: Prevention
6
18
Prenatal Chemical Exposures
5
18
Advanced Glycation End products (AGE)
4
15
Diabetes: Oxidative Stress
4
15
Dysbiosis
4
15
Alcoholic Liver Disease
3
14
Autism Spectrum Disorders
4
14
Bisphenol Toxicity
3
14
Influenza A
3
14
Sarcopenia
4
14
Autoimmune Diseases
4
13
Cancer Metastasis
3
13
Glaucoma
3
13
Hearing Loss
3
13
High Sugar Diet
3
13
Human Papillomavirus (HPV)
3
13
Otitis media
4
13
Schizophrenia
3
13
Stress
3
13
Amyotrophic lateral sclerosis (ALS)
2
12
Aneurysm: Aortic
2
12
Brain Inflammation
2
12
Cholesterol: High
2
12
Diabetic Neuropathy
2
12
Epilepsy
2
12
Fetal Origin of Adult Disease
6
12
Hepatitis: Autoimmune
2
12
Kidney Diseases
2
12
Kidney Stones
2
12
Learning disorders
2
12
Liver Disease
2
12
Lung Injury: Acute
2
12
Spinal Cord Injuries
2
12
Toxoplasma gondii Infection
2
12
Wound Healing
2
12
Complex Regional Pain Syndrome: Type I
2
11
Crohn's Disease
2
11
Diabetes
2
11
Drug-Induced Toxicity: Aromatase Inhibitors
2
11
Eczema
2
11
Folic Acid/Folate Deficiency
2
11
Graves Disease
2
11
Nasopharyngeal Cancer
2
11
Squamous cell carcinoma
2
11
Abortion: Spontaneous
1
10
Acute Myeloid Leukemia
1
10
Acute lymphoblastic leukemia (ALL)
1
10
Adiponectin: Low Levels
1
10
Alcohol Withdrawal
1
10
Alcoholism
1
10
Allergies: Childhood
1
10
Aneurysm
1
10
Angina Pectoris
1
10
Anxiety Disorders
1
10
Asthma: Bronchial
1
10
Attention Deficit Disorder with Hyperactivity
1
10
Benign Essential Tremor
1
10
Bile Duct Cancer
1
10
Birth Defects
1
10
Brain Ischemia
1
10
Breast Cancer: BRCA1
1
10
Breast Cancer: Estrogen
1
10
Burkitt Lymphoma
1
10
Burns: Severe
1
10
Caesarean section: Recovery
1
10
Calcification: Arterial
1
10
Carotid Artery Narrowing
1
10
Carpal Tunnel Syndrome
1
10
Cerebrovascular Disorders
1
10
Cervical Cancer
1
10
Cervical Dysplasia
1
10
Chemical Poisoning
1
10
Chemotherapy-Induced Toxicity: Doxorubicin
1
10
Chemotherapy-Induced Toxicity: Paclitaxel
1
10
Chemotherapy-Induced Toxicity: Peripheral Neuropathy
1
10
Child Behavior Disorders
1
10
Chronic Obstructive Lung Disease
1
10
Cirrhosis
1
10
Cleft Lip
1
10
Colic
1
10
Colon Polyps
1
10
Cystic Fibrosis
1
10
Cytomegalovirus Infections
1
10
Dental Caries
1
10
Dental Plaque
1
10
Diabetes: Cardiovascular Illness
1
10
Diabetic Ulcer
1
10
Diarrhea: in Children
1
10
Dyspnea
1
10
Eczema: Infant
1
10
Endocrine Cancer
1
10
Endometriosis
1
10
Enterocolitis: Necrotiziing
1
10
Essential Tremor
1
10
Fatigue
1
10
Fever
1
10
Fibroids: Uterine
1
10
Gallbladder Cancer
1
10
Gout
1
10
HIV Infections
1
10
Head Cancer
1
10
Heart Attack
1
10
Hematologic Diseases
1
10
Hemodialysis: Mortality
1
10
Hemorrhoids
1
10
Hodgkin Lymphoma
1
10
Homocysteine: Elevated
1
10
Hormone Imbalances: High Cortisol
1
10
Human Papilloma Virus
1
10
Hyperbilirubinemia: Hereditary
1
10
Incontinence
1
10
Incontinence: Fecal
1
10
Infants: Very Low Birth Weight/Low Birth Weight
1
10
Infertility: Female
1
10
Insect Bites: Repellent
1
10
Insomnia
1
10
Ischemic Heart Disease
1
10
Kawasaki Disease
1
10
Kidney Damage
1
10
Kidney Failure: Chronic
1
10
Kidney Transplant
1
10
Klebsiella Infections
1
10
Lactose Malabsorption
1
10
Laryngeal Cancer
1
10
Lymphoma: Follicular
1
10
Lymphoma: Non-Hodgkin
1
10
Maculopathy: Age-Related
1
10
Menopausal Syndrome
1
10
Mycobacterium tuberculosis
1
10
Myelodysplastic Syndromes
1
10
Myocardial Fibrosis
1
10
Nausea: Pregnancy-Associated
1
10
Neck Cancer
1
10
Nephropathy
1
10
Neurodegenerative Diseases
7
10
Non-Small-Cell Lung Carcinoma
1
10
Obesity: Abdominal
1
10
Obesity: Childhood
1
10
Obstructive uropathy
1
10
Organ Transplantation: Kidney
1
10
Pancreatitis
1
10
Perimenopausal Syndrome
1
10
Periodontitis
1
10
Pneumonitis
1
10
Postpartum Blood Loss
1
10
Postpartum Hemorrhage
1
10
Pregnancy: Prevention of Problems
1
10
Pregnancy: Urinary Tract Infections
1
10
Prehypertension
1
10
Prenatal Nutrition: Prevention of Problems
1
10
Psychological Well-Being
1
10
Psychoses
1
10
Pulmonary Fibrosis
1
10
Radiation
1
10
Respiratory Infections: Infants & Children
1
10
Retinopathy of Prematurity
1
10
Rhinovirus Infection
1
10
Sleep-Disordered Breathing: Infant/Child
1
10
Small-for-gestational-age infant
1
10
Spondylitis: Ankylosing
1
10
Stomach Cancer
1
10
Suicidal Behavior
1
10
Systemic Lupus Erythematosus
1
10
Thalassemia
1
10
Thrombocytopenia
1
10
Tuberculosis Drug Induced Toxicity
1
10
Tuberculosis: Drug Resistant
1
10
Tuberculosis: Spinal
1
10
Ulcers
1
10
Urolithiasis
1
10
Varicella
1
10
Venous Thromboembolism (VTE)
1
10
Vitamin B 12 Deficiency
1
10
Vitamin B6 Depletion
1
10
Vitamin E Deficiency
1
10
Weight Gain: Drug-Induced
1
10
Weight Problems
1
10
preeclampsia
1
10
High Fructose Diet
4
8
Lipopolysaccharide-Induced Toxicity
4
7
Diabetic Nephropathy
3
6
Neural Tube Defects
3
6
Glutathione Deficiency
1
5
Hyperinsulinism
3
5
Staphylococcus aureus infection
3
5
Cardiac Hypertrophy
2
4
Cerebral Ischemia
2
4
Colitis
2
4
Fructose-Induced Toxicity
2
4
Heat Stroke
2
4
Hepatic Steatosis
2
4
Myopia
2
4
Nicotine/Tobacco Toxicity
2
4
Streptococcus pneumoniae infection
2
4
Thrombosis
2
4
Antibiotic Toxicity
2
3
Autism
2
3
Escherichia coli Infections
2
3
Gingivitis
2
3
Graves Disease: Prevention
1
3
Leukemia
2
3
Liver Injury: Ischemia/reperfusion
2
3
Musculoskeletal Diseases
3
3
Neurodevelopmental Disorders
2
3
Osteomyelitis
1
3
Pertussis
1
3
Skin Cancer: Prevention
2
3
Ultraviolet Radiation Induced Damage
2
3
Whooping Cough
1
3
Acrylamide-induced toxicity
1
2
Aluminum Toxicity
1
2
Animal Diseases: Infectious
1
2
Arthritis
1
2
Bone Marrow Transplantation
1
2
Brain Injury: Traumatic
1
2
Cholesterol: LDL/HDL ratio
1
2
Circadian Dysregulation
2
2
Coronary Bypass Surgery
1
2
Cryptosporidiosis
1
2
Diabetes: Cataract
1
2
Diabetes: Liver Disease
1
2
Diabetes: Reproductive
1
2
Diabetic Microangiopathy
1
2
Drug Abuse
1
2
Drug-Induced Toxicity: Epilepsy Drugs
1
2
Electron Transport Chain Deficiencies: Mitochondrial
1
2
Erectile Dysfunction
1
2
Fibrosis
1
2
Gastrointestinal Inflammation
1
2
Graft vs Host Disease
1
2
Gram-Negative Bacterial Infections
1
2
Heart Attack: Recovery
1
2
Hyperthyroidism: Prevention
1
2
Infant Nutrition
2
2
Infertility
1
2
Infertility: Male
1
2
Intestinal Ischemia
1
2
Lead Poisoning
1
2
Leukemia: Acute promyelocytic leukemia
1
2
Liver Damage
1
2
Liver Damage: Aflatoxin-Induced
1
2
Malnourishment
1
2
Mitochondrial Dysfunction
1
2
Muscle Atrophy
1
2
Osteoarthritis: Knee
1
2
Ovariectomy Associated Adverse Changes
1
2
Preneoplastic Conditions
1
2
Prostatic Hyperplasia: Benign
1
2
Pulmonary Emphysema
1
2
Rotavirus Infections
1
2
Seizures
1
2
Seizures: Drug-Induced
1
2
Snake Bite: Venom Toxicity
1
2
Surgery: Anesthesiology
1
2
Tendon Rupture
1
2
Uterine Cervical Neoplasms
1
2
Vitamin A Deficiency
1
2
Actinic Keratosis
1
1
Addison's Disease
1
1
Attention Deficit Disorder
1
1
Attention Deficit Hyperactivity Disorder
1
1
Bacterial Infections: Resistance/Biofilm Formation
1
1
Bisphenol-A Toxicity
1
1
Blood Transfusion
1
1
Brain: Oxidative Stress
1
1
Breast Cancer: Chemically-Induced
1
1
Cachexia: Cancer
1
1
Cancers
1
1
Cancers: Drug Resistant
1
1
Childhood Deficiencies
1
1
Chronic Fatigue Syndrome
1
1
Constipation
1
1
Coronavirus Disease
1
1
Dermatitis
1
1
Diabetes: Cognitive Dysfunction
1
1
Dry Eye Syndromes
1
1
Endocrine Diseases
1
1
Eye Diseases
1
1
Glioblastoma
1
1
Haemophilus influenzae
1
1
Hashimoto's thyroiditis
1
1
Herpes Zoster
1
1
High-Grade Prostatic Intraepithelial Neoplastic Lesions
1
1
Hydrogen Peroxide Induced Toxicity
1
1
Irritable Bowel Syndrome
1
1
Larynx Neoplasms
1
1
Legionella pneumophila
1
1
Leukoplakia
1
1
Neurological Conditions
1
1
Organ Transplantation
1
1
Post-Traumatic Stress Disorders (PTSD)
1
1
Pseudomonas aeruginosa
1
1
Salmonella Infections
1
1
Skin Cancer
1
1
Sudden Infant Death Syndrome (SIDS)
1
1
Sugar (Sucrose) Toxicity
1
1
Vitamin Deficiency
1
1
5 Problematic Actions Researched for Risk Reduction
Name
AC
CK
Focus
Electromagnetic Field Harms
2
20
Western Diet
5
18
Blue Light (400−495 nm)
1
10
Biopsy: Various Tissue
1
1
Cesarean Delivery
1
1
2 Adverse Pharmacological Actions Researched for Risk Reduction
Name
AC
CK
Focus
Cardiotoxic
1
2
Nephrotoxic
1
2
374 Substances Researched for Risk Reduction
Name
AC
CK
Focus
Fruit: All
131
1474
Vegetables: All
117
1274
Vitamin D
123
1184
Coffee
68
836
Vitamin C
76
709
Green Tea
49
501
Fiber
48
494
Magnesium
40
457
Nuts
40
447
Yoghurt
36
346
Vitamin E
33
338
Flavonoids
39
331
Probiotics
33
295
Carotenoids
25
282
Soy
28
271
Cruciferous Vegetables
19
261
Chocolate
20
251
Omega-3 Fatty Acids
30
251
Lycopene
25
232
Vitamin A
21
214
Black Tea
18
186
Folic Acid
19
176
Selenium
18
166
Polyphenols
25
157
Olive Oil
15
141
Zinc
19
140
Garlic
14
136
Fish
13
130
Lutein
15
124
Anthocyanins
16
123
Tomato
12
123
Folate
11
122
Green Leafy Vegetables
9
121
Isoflavones
11
120
Vitamin B-6
13
113
Cryptoxanthin
11
112
EPA (Eicosapentaenoic Acid)
10
112
Melatonin
18
108
Almond
11
104
Polyunsaturated Fatty Acids (PUFAs)
12
104
DHA (Docosahexaenoic Acid)
9
101
beta-Carotene
9
100
Coenzyme Q10
13
96
Vitamin B-12
10
93
Apples
9
92
Egg
9
92
Berries: All
9
83
Zeaxanthin
11
83
Strawberry
9
82
Onion
8
81
Thiamine (B-1)
9
81
Cocoa
14
79
Alpha-Lipoic Acid
11
78
Walnut
12
77
Calcium
8
71
Cannabis
8
71
Olive
7
70
Peanut
6
70
Broccoli
6
63
Breast Milk
8
62
Folate: Dietary
7
62
Lactoferrin
8
62
Nuts: All
7
62
Alpha-Carotene
6
60
Carrot
4
60
Vitamin K
6
60
Turmeric
8
55
Lactobacillus plantarum
7
54
Pomegranate
6
54
Blueberry
7
53
Legumes
6
53
Fish Oil
6
52
Lactobacillus rhamnosus GG
6
52
Pycnogenol (Pine Bark)
5
52
Tea
3
50
Fermented Foods and Beverages
9
47
Vitamin E: alpha tocopherol
6
46
Resveratrol
12
44
Apple
5
43
Lactobacillus rhamnosus
6
43
Catechin
5
42
Homeopathic Medicine: All
5
42
Caffeine
8
40
Dietary Modification: Mediterranean Diet.
4
40
Kale
3
40
Lactobacillus Acidophilus
4
40
Orange
4
40
Soy Protein
4
40
Prebiotics
8
37
Lactobacillus paracasei
5
34
Betaine
4
32
Krill
4
32
Raisins
4
32
Riboflavin (Vitamin B-2)
4
32
Watermelon
4
32
B-Carotene
4
31
Garlic: Aged
4
31
Genistein
3
31
Iron
4
31
Mushrooms: All
4
31
B-complex
3
30
Beans: All
3
30
Black Currant
3
30
Choline
3
30
Collards
2
30
Leek
2
30
Lignans
3
30
Magnesium Sulfate
2
30
Monounsaturated fatty acids
3
30
Pear
2
30
Potassium
3
30
Red Wine Extract
3
30
Seaweed
3
30
Water
3
30
Nigella sativa (aka Black Seed)
5
26
Quercetin
5
26
Cannabinoids
6
25
NAC (N-acetyl-L-cysteine)
5
24
Rice Bran
4
24
Cabbage
3
23
Vitamin B-3 (Niacin)
4
23
Avocado
3
22
Ayahuasca
3
22
Bifidobacterium animalis
3
22
Broccoli Sprouts
3
22
Flaxseed
3
22
Grape
3
22
Milk: Fermented
3
22
Rhubarb
2
22
Cheese
2
21
Curcumin
10
21
EGCG (Epigallocatechin gallate)
8
21
Linoleic acid
2
21
Psyllium
2
21
Saffron
3
21
Vitamin K2
3
21
Alcohol
2
20
Avacado
1
20
Banana
2
20
Bok Choy
1
20
Chamomile
2
20
Chives
1
20
Citrus Peel
1
20
Coffee: Decaffeinated
1
20
Cranberry
2
20
Daidzein
2
20
Flavan-3-ols
1
20
Grains: All
1
20
Grape Seed Extract
2
20
Kiwifruit
2
20
L-Carnitine
1
20
Lactobacillus delbrueckii Subsp
2
20
Lemon Juice
2
20
Miso
2
20
Multivitamin
2
20
Mustard Greens
1
20
Oolong tea
2
20
Pistachio nut
2
20
Potato
2
20
Sage
2
20
Shallot
1
20
Sodium Bicarbonate
2
20
Soup
1
20
Sugar
1
20
Sunflower Seeds
2
20
Tea: Black
1
20
Tea: Green
1
20
Vitamin C: Intravenous
1
20
phytoestrogens
2
20
Berberine
6
19
Cannabidiol
6
19
Spirulina
5
18
Apigenin
4
16
Chokeberry
3
14
Rose Hips
3
14
Carnitine
3
13
Myricetin
3
13
Sea buckthorn
3
13
Beta Sitosterol
2
12
Coconut Oil
2
12
Dates
3
12
Echinacea
3
12
Grapefruit
2
12
Hawthorn
2
12
Hydroxytyrosol
2
12
Isothiocyanates
3
12
Rosemary
2
12
ALA (Alpha-Linolenic Acid)
2
11
Caffeic Acid
2
11
Culinary Herbs and Spices
2
11
Ginger
2
11
Grapes
2
11
Hazelnut
2
11
Nicotinamide
2
11
Amla Fruit
1
10
Bacillus Clausii
1
10
Bacillus subtilis
1
10
Bergamot
1
10
Beta-glucan
1
10
Bifidobacterium Bifidum
1
10
Bifidobacterium Lactis
1
10
Bifidobacterium Longum
1
10
Carnosine
1
10
Chicory
1
10
Chlorophyll
1
10
Chondroitin Sulfate
1
10
Cow Milk
1
10
Creatine
1
10
Cruciferous
1
10
Eicosapentaenoic acid (EPA)
1
10
Enterodiol
1
10
Enterolactone
1
10
Fenugreek
1
10
Galacto-oligosaccharides
1
10
Galactooligosaccharides
1
10
Gelatin
1
10
Green Coffee Bean
1
10
Guduchi
1
10
Henna
1
10
Hibiscus sabdariffa
1
10
Homeopathic Medicine: Rhus Toxicodendron
1
10
Honey
1
10
Hyaluronic Acid
1
10
Isothiocyanate
1
10
Lactobacillus Brevis
1
10
Lactobacillus helveticus
1
10
Lactobacillus probiotics
1
10
Lactobacillus reuteri
1
10
Lemon
1
10
Lemon Balm
1
10
Lingonberry
1
10
Manganese
1
10
Methionine
1
10
Minerals
1
10
Modified Arabinoxylan Rice Bran (MGN-3)
1
10
Moringa oleifera
1
10
Natto
1
10
Oleanolic acid
1
10
Oleuropein
1
10
Olive leaf extract
1
10
Omega-6 Fatty Acids
1
10
Papaya
1
10
Peanuts
1
10
Pecan
1
10
Pelargonium sidoides
1
10
Phosphatidylcholine
1
10
Phytosterols
1
10
Pine Bark Extract
1
10
Potatoes
1
10
Psilocybin
1
10
Psychedelics:All
1
10
Pumpkin
1
10
Purslane
1
10
Red Yeast Rice
1
10
Rice
1
10
Royal Jelly
1
10
Ruta Graveolens
1
10
Rye
1
10
Saturated fatty acids
1
10
Strontium
1
10
Vitamin B12
1
10
Vitamin K2: Menaquinone-7
1
10
Wheat Grass
1
10
Whole Grains
1
10
Wine
1
10
Astaxanthin
4
6
Dandelion
3
5
Elderberry
1
5
Ferulic acid
3
5
Brown Rice: Pre-Germinated
2
4
Delta-tetrahydrocannabinol (THC)
2
4
Hydrogen Water
2
4
Piperine
2
4
Red Cabbage
2
4
Sweet Potato: Purple
2
4
Cafestol
2
3
Ginsenosides
2
3
Myo-inositol
3
3
Nobiletin
2
3
Reishi Mushroom
2
3
Sulforaphane
2
3
Tanshinone IIA
2
3
Ursolic Acid
2
3
Apple Cider Vinegar
1
2
Apple Polyphenols
1
2
Arctigenin
1
2
Astragaloside
1
2
Bai Zhu
1
2
Bamboo
1
2
Barley
1
2
Bee Propolis
1
2
Bifidobacterium Breve
1
2
Black Raspberry
1
2
Black Tea Theaflavins
1
2
Blue Honeysuckle
1
2
Brown Rice
1
2
Burdock
1
2
Camel Milk
1
2
Camu Camu
1
2
Carvacrol
1
2
Celery
1
2
Chrysin
1
2
Cinnamon
2
2
Citrulline
1
2
Crocetin
1
2
Diosmetin
1
2
Diosmin
1
2
FOS (Fructooligosaccharides)
1
2
Flaxseed Oil
1
2
Geraniol
1
2
Ginkgo biloba
1
2
Ginseng (Korean)
1
2
Grapefruit peel extract
1
2
Hesperidin
1
2
Honokiol
1
2
Indole-3-Carbinol
2
2
Lactobacillus fermentum
1
2
Lentils
1
2
Licorice
1
2
Lime
1
2
Linden (Tilia)
1
2
Mango
1
2
Modified Citrus Pectin
1
2
Nettle
1
2
Noni
1
2
Oligonol
1
2
Palmitoylethanolamide
1
2
Panax Notoginseng
1
2
Pectin
1
2
Potato: Pigmented
1
2
Punicalagin
1
2
Raspberry
1
2
Spinach
1
2
Sweet Orange
1
2
Theaflavins
1
2
Theanine
1
2
Thymoquinone
1
2
Tongkat Ali
1
2
Toona sinensis
1
2
Vitamin E: Gamma-tocotrienol
1
2
Whey
1
2
White Tea
1
2
Xanthohumol
1
2
Apricot
1
1
Artemisinin
1
1
Ashwagandha
1
1
Bacopa
1
1
Beet
1
1
Black Pepper
1
1
Blackberries
1
1
Chlorophyllin
1
1
Chrysanthemum Indicum
1
1
Cilantro
1
1
Diosgenin
1
1
Eggplant
1
1
Emodin
1
1
Essential Fatty Acids
1
1
Essential Oils: Unspecified
1
1
Genipin
1
1
Gingerol
1
1
Glycyrrhizin
1
1
Hops
1
1
Inositol
1
1
Kaempferol
1
1
Kefir
1
1
Kimchi
1
1
Lemon Verbena
1
1
Medicinal Mushrooms
1
1
Naringenin
1
1
Rooibos
1
1
Rosemary: Essential Oil
1
1
Silymarin
1
1
Vitamin E: Gamma-Tocopherol
1
1
Zerumbone
1
1
56 Therapeutic Actions Researched for Risk Reduction
Name
AC
CK
Focus
Exercise
89
653
Dietary Modification: Mediterranean Diet
65
636
Breastfeeding
37
273
Dietary Modification: Vegetarian
27
253
Exercise: Cycling
22
232
Yoga
18
153
Tai Chi
10
111
Exercise: Aerobic
12
94
Sunlight exposure
17
92
Whole-Body Vibration
5
70
Exercise: Green
5
60
Exercise: Resistance Training
6
52
Dietary Modification: Low Carbohydrate/Ketogenic
5
51
Meditation
6
42
Shinrin-yoku (taking in the atmosphere of the forest)
4
41
Acupressure
3
40
Exercise: Running
4
34
Acupuncture
5
32
Light Therapy
4
32
Dietary Modification: Vegan Diet
2
30
Grounding: Contact with the Earth
3
30
Fasting/Caloric Restriction
5
24
Hyperbaric Treatment
4
24
Mediterranean diet
5
23
Mindfullness Training
3
21
Dietary Modification: Non-Western Diet
2
20
Music
2
20
Qigong
1
20
Integrative Medicine
2
11
Microbiota Transfer Therapy
2
11
Sauna Therapy
2
11
Thermal Therapy: Far-Infrared
2
11
Biofeedback
1
10
Blue Light Blocking
1
10
Cognitive Behavioural Approaches
1
10
Cryotherapy
1
10
Dietary Modification: Low Carbohydrate
1
10
Dietary Modification: Low Glycemic Diet
1
10
Dietary Modification: Low Starch/Low Dairy
1
10
Dietary Modification: Raw Food
1
10
Emotional Freedom Technique
1
10
Exercise: Endurance
1
10
Exercise: Swimming
1
10
Homeopathic Treatment
1
10
Massage/Therapeutic Touch
1
10
Nasal Irrigation
1
10
Organic Farming
1
10
Yogic Technique: Sudarshan kriya
1
10
Kundalini Yoga
1
3
Lifestyle Changes: Positive
1
3
Sunlight Exposure: UVB Light
2
3
Dietary Modification: Grain-Free/Grain-Reduced Diet
1
2
Dietary Modification: Low Fat Diet
1
2
Dietary Modification: Soy Free
1
2
Electroacupuncture
1
2
Laser Treatment: Low-Level
1
2
113 Pharmacological Actions Researched for Risk Reduction
Name
AC
CK
Focus
Chemopreventive
160
1588
Cardioprotective
129
1079
Antioxidants
110
600
Anti-Inflammatory Agents
107
521
Hypolipidemic
60
456
Antihypertensive Agents
45
443
Neuroprotective Agents
69
416
Antidepressive Agents
46
357
Anticholesteremic Agents
30
294
Anticarcinogenic Agents
40
263
Prophylactic Agents
30
223
Hypoglycemic Agents
32
217
Hepatoprotective
34
203
Gastrointestinal Agents
25
143
Interleukin-6 Downregulation
17
98
Immunomodulatory
19
97
Renoprotective
11
80
Tumor Necrosis Factor (TNF) Alpha Inhibitor
23
76
Anti-Bacterial Agents
7
71
Antiviral Agents
11
66
Cardiovascular Agents
4
60
Anti-Asthmatic Agents
6
54
NF-kappaB Inhibitor
12
46
Anti-Anxiety Agents
7
45
Antiproliferative
8
45
Osteoprotective
7
38
Anti-atherogenic
7
37
Chemoprotective Agents
4
32
Gastroprotective
4
32
Malondialdehyde Down-regulation
4
32
Chemotherapeutic
4
31
Matrix metalloproteinase-2 (MMP-2) inhibitor
4
23
Matrix metalloproteinase-9 (MMP-9) inhibitor
4
23
Anti-Allergic Agents
3
22
Alpha-amylase inhibitor
2
20
Genoprotective
2
20
Insulin Sensitizers
2
20
MicroRNA modulator
6
19
Anti-Glycation Agents
5
17
Cyclooxygenase 2 Inhibitors
5
17
Interleukin-1 beta downregulation
5
17
Apoptotic
4
15
Cytoprotective
4
14
Superoxide Dismutase Up-regulation
3
13
Alpha-glucosidase inhibitor
2
12
Anti-Tumor
2
12
Catalase Up-Regulation
2
12
Cell cycle arrest
2
12
Interleukin-10 downregulation
2
12
Interleukin-4 downregulation
2
12
Interleukin-5 downregulation
2
12
Nitric Oxide Enhancer
2
12
DNA Repair Up-regulation
2
11
Immunostimulatory
2
11
Interleukin-8 downregulation
2
11
Anti-Fibrotic
1
10
Antidiarrheals
1
10
Appetite Suppresant
1
10
Disinfectants
1
10
Enzyme Inhibitors
1
10
Estrogen Receptor Modulators
1
10
Insulin-Like Growth Factor Inhibition/Downregulation
1
10
Interleukin-23 Downregulation
1
10
Malonaldehyde (MDA) Down-Regulation
1
10
Nitric Oxide Inhibitor
1
10
Radioprotective
1
10
Telomere Protective
1
10
Uricosuric Agents
1
10
Wnt/β-catenin pathway down-regulation
1
10
Anti-Apoptotic
5
9
Heme oxygenase-1 up-regulation
3
6
Interferon Gamma Reducer
3
6
Glucagon Like peptide 1 (GLP-1) Up-regulation
1
5
Neurogenesis
3
5
Pancreato Protective Agents
3
5
Vasoprotective
1
5
Insulin Down-Regulation
2
4
Insulin-releasing
3
4
Interleukin-2 Downregulation
2
4
SIRT1 Activator
2
4
Anti-Platelet
2
3
Antineoplastic Agents
2
3
Autophagy Inhibitors
2
3
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
2
3
Nrf2 activation
2
3
Photoprotective
2
3
Prostaglandin PGE2 downregulation
2
3
Adiponectin Down-Regulation
1
2
Antimicrobial
2
2
Antinoceceptive
1
2
Antiparasitic Agents
1
2
Appetite Depressants
1
2
Autophagy Up-regulation
1
2
Chelating Agents
1
2
Fibroblast growth factor 21 upregulation
1
2
Heat Shock Protein Inducer
1
2
Interleukin-12 downregulation
1
2
Matrix Metalloproteinase-12 (MMP-12) Inhibitor
1
2
Tumor Suppressor Protein p53 Upregulation
1
2
anti-inflammatory
1
2
Adiponectin upregulation
1
1
Angiogenesis Inducing Agents
1
1
Angiogenesis Inhibitors
1
1
Anti-Estrogenic
1
1
Anti-metastatic
1
1
Anti-thrombotic
1
1
Anticonvulsants
1
1
Antimutagenic Agents
1
1
Cholinesterase Inhibitors
1
1
Glucose Uptake Optimization
1
1
Interleukin-17 downregulation
1
1
Platelet Aggregation Inhibitors
1
1
Wnt/β-catenin signaling pathway modulation
1
1
Research Articles
1708
Cumulative Knowledge Score
2763
Overall Research Rating
EXCELLENT
View the Evidence:
1818 Abstracts with Risk Reduction Research
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[+]
Adjunctive melatonin supplementation can significantly improve the periodontal status after non-surgical treatment.
Mar 14, 2022
Click here to read the entire abstract
Pubmed Data
: Inflammopharmacology. 2022 Mar 15. Epub 2022 Mar 15. PMID:
35290552
Article Published Date
: Mar 14, 2022
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Melatonin
Diseases
:
Periodontitis
Additional Keywords
:
Risk Reduction
[+]
The association of garlic intake and cardiovascular risk factors.
Mar 28, 2022
Click here to read the entire abstract
Pubmed Data
: Crit Rev Food Sci Nutr. 2022 Mar 29:1-19. Epub 2022 Mar 29. PMID:
35348024
Article Published Date
: Mar 28, 2022
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Garlic
Diseases
:
Cardiovascular Diseases
Pharmacological Actions
:
Cardioprotective
Additional Keywords
:
Risk Reduction
[+]
A 10 g/d increment in dietary fiber intake was associated with a 31% reduction in Barrett's esophagus and esophageal cancer risk.
Oct 12, 2015
Click here to read the entire abstract
Pubmed Data
: Crit Rev Food Sci Nutr. 2015 Oct 13:0. Epub 2015 Oct 13. PMID:
26462851
Article Published Date
: Oct 12, 2015
Study Type
: Meta Analysis
Additional Links
Substances
:
Fiber
Diseases
:
Barrett Esophagus
,
Esophageal Cancer
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Risk Reduction
[+]
A high intake of dietary fiber was associated with a reduced risk of pancreatic cancer.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Asia Pac J Clin Nutr. 2017 Jan ;26(1):89-96. PMID:
28049267
Article Published Date
: Dec 31, 2016
Study Type
: Meta Analysis
Additional Links
Substances
:
Fiber
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Risk Reduction
[+]
A high level of vitamin E might be a protective factor for populations at risk for pancreatic cancer.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Med Sci Monit. 2015 ;21:1249-55. Epub 2015 May 1. PMID:
25929754
Article Published Date
: Dec 31, 2014
Study Type
: Meta Analysis
Additional Links
Substances
:
Vitamin E
Diseases
:
Pancreatic Cancer
Additional Keywords
:
Risk Reduction
[+]
A higher adherence to Mediterranean diet is associated with a lower risk of frailty in old people.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: J Nutr Health Aging. 2018 ;22(5):613-618. PMID:
29717762
Article Published Date
: Dec 31, 2017
Study Type
: Meta Analysis, Review
Additional Links
Diseases
:
Aging
Therapeutic Actions
:
Dietary Modification: Mediterranean Diet
Additional Keywords
:
Risk Reduction
[+]
A higher intake of sugar-sweetened fruit juice was significantly associated with risk of type 2 diabetes, while intake of 100% fruit juice was not associated with risk of developing type 2 diabetes.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2014 ;9(3):e93471. Epub 2014 Mar 28. PMID:
24682091
Article Published Date
: Dec 31, 2013
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Fruit: All
Diseases
:
Diabetes Mellitus: Type 2
,
Diabetes Mellitus: Type 2: Prevention
Additional Keywords
:
Fruit Juice
,
Risk Reduction
Problem Substances
:
Sugar Sweetened Beverages
[+]
A meta-analysis coffee consumption and all-cause and cause-specific mortality.
May 03, 2019
Click here to read the entire abstract
Pubmed Data
: Eur J Epidemiol. 2019 May 4. Epub 2019 May 4. PMID:
31055709
Article Published Date
: May 03, 2019
Study Type
: Meta Analysis
Additional Links
Substances
:
Coffee
Diseases
:
All-Cause Mortality
,
Cardiac Mortality
Additional Keywords
:
Risk Reduction
[+]
A systematic review and meta-analysis running to lower resting blood pressure.
Feb 29, 2020
Click here to read the entire abstract
Pubmed Data
: Sports Med. 2020 Mar ;50(3):531-541. PMID:
31677122
Article Published Date
: Feb 29, 2020
Study Type
: Meta Analysis, Review
Additional Links
Diseases
:
Hypertension
Therapeutic Actions
:
Exercise
,
Exercise: Running
Pharmacological Actions
:
Antihypertensive Agents
Additional Keywords
:
Risk Reduction
[+]
A vegetarian diet could lower the incidence and mortality from ischemic heart disease and reduced risk of incidence from total cancer.
Feb 05, 2016
Click here to read the entire abstract
Pubmed Data
: Crit Rev Food Sci Nutr. 2016 Feb 6:0. Epub 2016 Feb 6. PMID:
26853923
Article Published Date
: Feb 05, 2016
Study Type
: Meta Analysis, Review
Additional Links
Diseases
:
Cancers: All
,
Heart Disease: Ischemic
Therapeutic Actions
:
Dietary Modification: Vegan Diet
,
Dietary Modification: Vegetarian
Additional Keywords
:
Risk Reduction
[+]
Acupressure could have a role in reducing the rate of caesarean delivery and decreasing the duration of labor in parturient women.
Jul 28, 2016
Click here to read the entire abstract
Pubmed Data
: Int J Gynaecol Obstet. 2016 Jul 29. Epub 2016 Jul 29. PMID:
27569023
Article Published Date
: Jul 28, 2016
Study Type
: Meta Analysis
Additional Links
Diseases
:
Birth: Labor & Delivery
,
Cesarean Section
Therapeutic Actions
:
Acupressure
Additional Keywords
:
Risk Reduction
[+]
Adoption of a Mediterranean dietary pattern was associated with lower risk of the MetS.
Aug 24, 2016
Click here to read the entire abstract
Pubmed Data
: Int J Food Sci Nutr. 2016 Aug 25:1-11. Epub 2016 Aug 25. PMID:
27557591
Article Published Date
: Aug 24, 2016
Study Type
: Meta Analysis
Additional Links
Diseases
:
Metabolic Syndrome X
Therapeutic Actions
:
Dietary Modification: Mediterranean Diet
Additional Keywords
:
Risk Reduction
[+]
Almond consumption may reduce the risk of cardiovascular disease.
Jun 26, 2019
Click here to read the entire abstract
Pubmed Data
: Adv Nutr. 2019 Jun 27. Epub 2019 Jun 27. PMID:
31243439
Article Published Date
: Jun 26, 2019
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Almond
Diseases
:
Cardiovascular Diseases
Pharmacological Actions
:
Cardioprotective
,
Hypolipidemic
Additional Keywords
:
Risk Reduction
[+]
Alpha-Lipoic acid supplementation significantly reduces the risk of obesity.
Feb 23, 2020
Click here to read the entire abstract
Pubmed Data
: Int J Clin Pract. 2020 Feb 24:e13493. Epub 2020 Feb 24. PMID:
32091656
Article Published Date
: Feb 23, 2020
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Alpha-Lipoic Acid
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
,
Risk Reduction
[+]
An increased consumption of coffee may reduce the risk of liver cancer.
May 01, 2007
Click here to read the entire abstract
Pubmed Data
: Gastroenterology. 2007 May ;132(5):1740-5. Epub 2007 Mar 24. PMID:
17484871
Article Published Date
: May 01, 2007
Study Type
: Meta Analysis
Additional Links
Substances
:
Coffee
Diseases
:
Liver Cancer: Prevention
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Risk Reduction
[+]
Any form of cycling seems to be associated with lower cardiovascular disease risk.
Jun 30, 2019
Click here to read the entire abstract
Pubmed Data
: Br J Sports Med. 2019 Jul ;53(14):870-878. Epub 2019 May 31. PMID:
31151937
Article Published Date
: Jun 30, 2019
Study Type
: Meta Analysis
Additional Links
Diseases
:
Cardiac Mortality
,
Cardiovascular Diseases
Therapeutic Actions
:
Exercise: Cycling
Pharmacological Actions
:
Cardioprotective
Additional Keywords
:
Risk Reduction
[+]
Association of cycling with risk of all-cause and cardiovascular disease mortality
Mar 27, 2021
Click here to read the entire abstract
Pubmed Data
: Sports Med. 2021 Mar 28. Epub 2021 Mar 28. PMID:
33774807
Article Published Date
: Mar 27, 2021
Study Type
: Meta Analysis, Review
Additional Links
Diseases
:
Cardiac Mortality
,
Cardiovascular Diseases
Therapeutic Actions
:
Exercise: Cycling
Additional Keywords
:
Risk Reduction
[+]
Association of high amounts of physical activity with mortality risk.
Aug 11, 2019
Click here to read the entire abstract
Pubmed Data
: Br J Sports Med. 2019 Aug 12. Epub 2019 Aug 12. PMID:
31406017
Article Published Date
: Aug 11, 2019
Study Type
: Meta Analysis, Review
Additional Links
Diseases
:
Cardiac Mortality
Therapeutic Actions
:
Exercise
Additional Keywords
:
Physical Activity
,
Risk Reduction
[+]
Associations of vegetable and fruit consumption with metabolic syndrome.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Public Health Nutr. 2018 06 ;21(9):1693-1703. Epub 2018 Mar 6. PMID:
29506604
Article Published Date
: Dec 31, 2017
Study Type
: Meta Analysis
Additional Links
Substances
:
Fruit: All
,
Vegetables: All
Diseases
:
Metabolic Syndrome X
Additional Keywords
:
Risk Reduction
[+]
Associations show no clear association between egg intake and increased or decreased risk of coronary heart disease.
Oct 05, 2016