Selective Cytotoxicity

Name	AC	CK	Focus
2,4-Dichlorophenoxyacetic acid	1	1

Name	AC	CK
Breast Cancer	43	62
Cancers: All	24	30
Breast Cancer: Triple Negative	16	25
Lung Cancer	14	23
Colon Cancer	15	21
Liver Cancer	15	17
Pancreatic Cancer	10	17
Prostate Cancer	11	14
Cancer Metastasis	4	13
Cervical Cancer	9	11
Bladder Cancer	6	10
Gastric Cancer	8	10
Oxidative Stress	5	10
Colorectal Cancer	5	8
Melanoma	7	8
Multiple Myeloma	3	8
Glioblastoma	7	7
Kidney Cancer	7	7
Lymphoma	3	7
Glioma	5	6
Cancers: Multi-Drug Resistant	1	5
Neuroblastoma	4	5
Tumors	5	5
Cancers: Drug Resistant	3	4
Carcinoma: Non-Small-Cell Lung	4	4
Oral Cancer	4	4
Skin Cancer	3	4
Cancer Stem Cells	3	3
Head and Neck Cancer	2	3
Leukemia	3	3
Leukemia: Acute myelogenous leukemia (AML)	3	3
Acute Myeloid Leukemia	2	2
Acute T cell Leukemias	1	2
Acute lymphoblastic leukemia (ALL)	2	2
Bone Cancer	1	2
Leishmaniasis	1	2
Lymphoma: B-Cell	2	2
Non-Small-Cell Lung Carcinoma	2	2
Ovarian Cancer	2	2
Pheochromocytoma	1	2
Simian virus 40 (SV40)	2	2
Skin Cancer: Squamous Cell	2	2
Smoldering multiple myeloma (SMM)	1	2
Squamous cell carcinoma	2	2
Bacterial Infections	1	1
Bladder Cancer: Prevention	1	1
Brain Cancer Stem Cells	1	1
Breast Cancer Stem Cells	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Chemotherapy-Induced Toxicity: Irinotecan	1	1
Chronic Lymphocytic Leukemia	1	1
Chronic Myeloid Leukemia	1	1
Colon Cancer Stem Cells	1	1
Encephalitis: Japanese	1	1
Endometrial Cancer	1	1
Esophageal Cancer	1	1
Fibrosarcoma	1	1
HIV Infections	1	1
Helicobacter Pylori Infection	1	1
Hepatoma	1	1
Human Papillomavirus (HPV)	1	1
Inflammation	1	1
Laryngeal Cancer	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Leukemia: Multi-Drug Resistant	1	1
Leukoplakia	1	1
Liver Cancer Stem Cells	1	1
Lung Cancer: Prevention	1	1
Malignant Melanoma	1	1
Myeloproliferative Disorders	1	1
Osteosarcoma	1	1
Ovarian Cancer Stem Cell	1	1
Promyelocytic leukemia	1	1
Protozoan Infections	1	1

Name	AC	CK
Curcumin	14	20
Vitamin C	10	14
Dandelion	5	11
Frankincense	3	11
Cannabinoids	3	8
Flavonoids	8	8
Genistein	4	8
Piperine	4	8
Cannabinoids: Synthetic	2	7
Lemongrass	2	7
Sulforaphane	3	7
Papaya	2	6
Piperlongumine	4	6
Achiote	1	5
Ashwagandha	5	5
Citral	1	5
Goji	1	5
Myricetin	4	5
NAC (N-acetyl-L-cysteine)	1	5
Polyphenols	5	5
Resveratrol	5	5
Apigenin	3	3
Artemisinin	2	3
Bee Propolis	3	3
Berberine	3	3
Carotenoids	2	3
Delta-tetrahydrocannabinol (THC)	2	3
Lichens	3	3
Neem	2	3
Olive Oil	3	3
Psychedelics:All	2	3
Sage	3	3
Shiitake Mushroom	2	3
Wogonin	2	3
Aloe Vera	2	2
Anthocyanins	2	2
Apple Polyphenols	2	2
Bamboo	1	2
Betulinic acid	2	2
Carrot	2	2
Catechin	2	2
Chaga Mushroom (Inonotus obliquus)	2	2
Cocoa	2	2
Cucumber	1	2
Cucurbitacin B	1	2
Curcumol	1	2
DHA (Docosahexaenoic Acid)	1	2
EGCG (Epigallocatechin gallate)	2	2
Fennel	2	2
Kaempferol	2	2
Nettle	2	2
Oak	1	2
Oleocanthal	2	2
Palash	1	2
Piceatannol	2	2
Quercetin	2	2
Rose	2	2
Saffron	1	2
Solanum nigrum (black nightshade)	1	2
Sumac	2	2
Turmeric: Topical	1	2
Verbascoside	1	2
Vitamin C: Intravenous	2	2
Whey	1	2
beta-Carotene	2	2
6-Shogaol	1	1
Arctigenin	1	1
Astaxanthin	1	1
Baicalein	1	1
Beet	1	1
Betanins	1	1
Bilberry	1	1
Biochanin A	1	1
Black Tea	1	1
Boswellia	1	1
Cafestol	1	1
Caffeic Acid	1	1
Caffeic acid phenethyl ester	1	1
Camel Milk	1	1
Cannabidiol	1	1
Cat's Claw	1	1
Chokeberry	1	1
Cleavers	1	1
Clove	1	1
Cranberry	1	1
Cruciferous Vegetables	1	1
Damnacanthal	1	1
Deguelin	1	1
Diosmetin	1	1
Elderberry	1	1
Elecampane	1	1
Ellagic Acid	1	1
Emodin	1	1
Feijoa	1	1
Feverfew	1	1
Fisetin	1	1
Fucoxanthin	1	1
Gallic Acid	1	1
Garlic	1	1
Gastrodin	1	1
Geranium	1	1
Gingerol	1	1
Guarana	1	1
Hemp Seed	1	1
Hibiscus	1	1
Honeydew (melon)	1	1
Horehound	1	1
Horse Chestnut	1	1
Indole-3-Carbinol	1	1
Kahweol	1	1
Kefir	1	1
Lactoferrin	1	1
Loquat	1	1
Lutein	1	1
Luteolin	1	1
Mulberry	1	1
Naringenin	1	1
Nobiletin	1	1
Noni	1	1
Okra	1	1
Oleuropein	1	1
Olive leaf extract	1	1
Oridonin	1	1
Orthosiphon	1	1
Patchouli	1	1
Peach	1	1
Phellinus Linteus	1	1
Pine Bark Extract	1	1
Pine Needle	1	1
Pinus Massoniana Bark	1	1
Piperidines	1	1
Plum	1	1
Prickly Pear Cactus	1	1
Pterocarpus marsupium	1	1
Rosemary	1	1
Sandalwood	1	1
Sesamol	1	1
Soursop	1	1
Sweet Cherry	1	1
Tannic Acid	1	1
Tea	1	1
Tea Tree	1	1
Theaflavins	1	1
Thyme	1	1
Thymoquinone	1	1
Tocotrienol: Gamma	1	1
Tomato	1	1
Vitamin D	1	1
Walnut	1	1
Xanthohumol	1	1
Zerumbone	1	1

Name	AC	CK	Focus
Ultrasound therapy	1	1

Name	AC	CK
Apoptotic	128	179
Antiproliferative	77	95
Cell cycle arrest	33	53
Antineoplastic Agents	22	33
Cytotoxic	22	24
Tumor Suppressor Protein p53 Upregulation	13	21
Chemopreventive	14	20
Antioxidants	18	18
Anti-metastatic	11	16
Chemosensitizer	10	16
Chemotherapeutic	13	15
Caspase-3 Activation	6	10
Anticarcinogenic Agents	8	9
Autophagy Up-regulation	5	9
Bcl-2 protein down-regulation	4	8
Angiogenesis Inhibitors	4	7
Caspase-9 Activation	2	6
Bax/Bcl2 ratio: Increase	1	5
Cytoprotective	1	5
Nrf2 activation	1	5
P38 Mitogen-Activated Protein Kinase Modulator	1	5
Anti-Angiogenic	3	3
Histone deacetylase inhibitor	3	3
Matrix metalloproteinase-2 (MMP-2) inhibitor	2	3
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	3
NF-kappaB Inhibitor	3	3
Radioprotective	2	3
Radiosensitizer	2	3
Anti-Bacterial Agents	2	2
Anti-Tumor	2	2
Autophagy Inhibitors	1	2
Cytotoxicity	1	2
Immunomodulatory	1	2
Leishmanicidal	1	2
Anti-HIV Agents	1	1
Anti-Infective Agents	1	1
Anti-Inflammatory Agents	1	1
Antifungal Agents	1	1
Antiprotozoal Agents	1	1
Antiviral Agents	1	1
Caspase-8 activation	1	1
Chemoprotective Agents	1	1
Cyclooxygenase 2 Inhibitors	1	1
Epidermal growth factor receptor (EGFR) inhibitor	1	1
Glucose transporter-1 (GLUT1) expression down-regulation	1	1
Heat Shock Protein Inducer	1	1
Hepatoprotective	1	1
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	1
Interleukin-6 Downregulation	1	1
Multidrug Resistance Gene Modulators	1	1
P21 Activation	1	1
Phase II Detoxification Enzyme Inducer	1	1
Photoprotective	1	1
Topoisomerase II Inhibitor	1	1
Tumor Necrosis Factor (TNF) Alpha Inhibitor	1	1
Tumor Suppressor Protein p73 Upregulation	1	1
Wnt/β-catenin pathway down-regulation	1	1

Breast cancer amelioration by Butea monosperma in-vitro and in-vivo.May 09, 2018

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Pubmed Data : J Ethnopharmacol. 2018 May 10 ;217:54-62. Epub 2018 Jan 31. PMID: 29366766

Article Published Date : May 09, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Palash

Diseases : Breast Cancer, Breast Cancer: Triple Negative , Cancer Metastasis

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antiproliferative , Apoptotic

Additional Keywords : Phytotherapy, Plant Extracts, Selective Cytotoxicity

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Cannabinoids inhibit the growth of melanoma cells but not of normal melanocytes.Nov 30, 2006

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Wogonin significantly sensitized resistant HNC cells to cisplatin both in vitro and in vivo. Aug 19, 2016

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Pubmed Data : Apoptosis. 2016 Aug 20. Epub 2016 Aug 20. PMID: 27544755

Article Published Date : Aug 19, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Wogonin

Diseases : Cancers: Drug Resistant, Head and Neck Cancer

Pharmacological Actions : Chemosensitizer

Additional Keywords : Selective Cytotoxicity

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Nobiletin selectively inhibits oral cancer cell growth by promoting apoptosis and DNA damage in vitro.Jul 03, 2020

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Pubmed Data : Fitoterapia. 2012 Sep ;83(6):1000-7. Epub 2012 Jun 12. PMID: 22698713

Article Published Date : Aug 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Orthosiphon

Diseases : Cancers: All

Pharmacological Actions : Anti-Angiogenic, Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Phytotherapy, Plant Extracts, Selective Cytotoxicity

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Antiviral therapies based on antioxidants are promising therapeutic agents against japanese encephalitis.Jun 30, 2014

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Pubmed Data : PLoS One. 2013 ;8(2):e56234. Epub 2013 Feb 12. PMID: 23424652

Article Published Date : Dec 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Betulinic acid

Diseases : Prostate Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Selective Cytotoxicity

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Biochanin A can selectively target cancer cells and inhibit multiple signaling pathways in HER-2-positive breast cancer cells.Dec 31, 2008

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Pubmed Data : J Ethnopharmacol. 2016 Jun 20 ;186:305-10. Epub 2016 Apr 13. PMID: 27085941

Article Published Date : Jun 19, 2016

Study Type : In Vitro Study

Additional Links

Substances : Cleavers

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Plant Extracts, Selective Cytotoxicity

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Combination therapy with vitamin C could eradicate cancer stem cells.Jan 02, 2020

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Hibiscus flower extract selectively induces apoptosis in breast cancer cells.May 05, 2019

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Pubmed Data : BMC Complement Altern Med. 2019 May 6 ;19(1):98. Epub 2019 May 6. PMID: 31060537

Article Published Date : May 05, 2019

Study Type : In Vitro Study

Additional Links

Substances : Hibiscus

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemotherapeutic

Additional Keywords : Plant Extracts, Selective Cytotoxicity

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In-vitro morphological assessment of apoptosis induced by nimbolide.Dec 31, 2018

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Naringenin induced apoptosis in human skin carcinoma cells with little affect in normal skin cells.Dec 31, 2013

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Pubmed Data : PLoS One. 2014 ;9(10):e110003. Epub 2014 Oct 16. PMID: 25330158

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The results showed that 80 µM apigenin could effectively induce apoptosis and overproduction of ROS in MCF-7 cells. Oct 31, 2014

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Pubmed Data : Scanning. 2014 Nov-Dec;36(6):622-31. Epub 2014 Oct 18. PMID: 25327419

Article Published Date : Oct 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Apigenin

Diseases : Breast Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic

Additional Keywords : Dose Response, Selective Cytotoxicity

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The use of phytochemicals may be a true therapeutic strategy for eradicating cancer through the elimination of CSCs.Dec 31, 2014

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Pubmed Data : Anticancer Agents Med Chem. 2014 Dec 3. Epub 2014 Dec 3. PMID: 25495463

Article Published Date : Dec 02, 2014

Study Type : Review

Additional Links

Substances : Catechin , Polyphenols, Tea

Diseases : Bladder Cancer, Bladder Cancer: Prevention

Pharmacological Actions : Anti-metastatic, Anticarcinogenic Agents, Antioxidants, Apoptotic, Cell cycle arrest

Additional Keywords : Selective Cytotoxicity

[+]

Thymoquinone is a potential anticancer agent targeting HIF-1α.Mar 02, 2019

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Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2016 ;62(2):62-7. Epub 2016 Feb 29. PMID: 26950453

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Nettle

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Plant Extracts, Selective Cytotoxicity

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View the Evidence: 200 Abstracts with Selective Cytotoxicity Research

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Curcumin and citral in combination may be a useful therapeutic intervention for breast cancer.Aug 31, 2015

Dandelion root induces selective apoptosis and autophagy in human pancreatic cancer cells in a dose and time dependent manner.Sep 30, 2012

Goji berry extracts have chemopreventive potential in breast cancer treatment.Nov 01, 2015

Human bladder cancer cells and immortalized normal bladder cells were studied using Frankincense oil; Frankincense oil appears to distinguish cancerous from normal bladder cells and suppress cancer cell viability. Dec 31, 2008

Piperine was found to exert selective cytotoxic effects against A549 cells in a dose-dependent manner.Mar 31, 2014

Sulforaphane regulates xenobiotic metabolism phase II and III enzymes differently in colorectal cancer and untransformed epithelial colon cells.Oct 31, 2016

The annatto constituent cis-bixin has intriguing selective anti-myeloma activity.Sep 30, 2010

The combination of centchroman with genistein has selective cytotoxic effect for human breast cancer cell lines.Oct 31, 2016

The present data suggest that targeting CB(1)/CB(2) may have therapeutic potential for the treatment of mantle cell lymphoma.Oct 31, 2006

This study compares Boswellia sacra essential oil hydrodistilled at 100 °C vs 78 °C in inducing cancer cell death in cultured breast cancer cells; the oil prepared at 100 °C was more potent in inducing breast cancer cell-specific cytotoxicity.Dec 31, 2010

"A Novel Curcumin-based Vaginal Cream Vacurin Selectively Eliminates Apposed Human Cervical Cancer Cells.:Dec 08, 2012

A nanoformulation of THC revealed a statistically significant selective cytotoxic effect towards lung cancer cell lines.Jun 19, 2015

An ethanol extract of Shitake (Lentinula elodes) selectively kills skin cancer cells in mice. Mar 18, 2005

Artesunate, a novel derivative of artemisin, has in vitro and in vivo anticancer activity against pancreatic cancer. It exhibits selective cytotoxicity and has in vivo antitumor activity similar to that of gemcitabine.Apr 01, 2010

Ascorbate combined with ionizing radiation decreased tumor growth and increased survival, without damaging the gastrointestinal tract.Jun 15, 2015

Breast cancer amelioration by Butea monosperma in-vitro and in-vivo.May 09, 2018

Cannabinoids inhibit the growth of melanoma cells but not of normal melanocytes.Nov 30, 2006

Crocin from Saffron (Crocus sativus) possesses significant anti-proliferation effects on human colorectal cancer cells.Sep 01, 2007

Cucurbitacin B significantly and specifically inhibited prostate cancer cell growth with a low IC50 value of 0.3 μM in PC-3 and LNCaP cells accompanied by marked apoptosis.Jul 09, 2014

Curcumol exhibited time and concentration dependent anti-proliferative and apoptosis-inductive activities in SPC-A-1human lung adenocarcinoma cells.Dec 31, 2014

Dandelion and lemongrass extracts were able to significantly reduce the tumour burden in prostate cancer xenograft models.Dec 31, 2018

Docosahexaenoic acid selectively induces apoptosis in tumor-derived cells and suppress tumor growth in gastric cancer.Jan 24, 2021

Extracts of Neem leaf were effective in inducing apoptosis in leukemia and colon cancer cells.Oct 31, 2015

Functional characterization of a potent anti-tumor polysaccharide in a mouse model of gastric cancer.Feb 14, 2019

Harmines inhibit cancer cell growth through coordinated activation of apoptosis and inhibition of autophagy.Jan 24, 2018

Hepatomas are exquisitely sensitive to pharmacologic ascorbate.Dec 31, 2018

Liposomal curcumin dry powders are a promising medication for inhalation treatment of lung cancer with high therapeutic efficiency.Apr 30, 2018

Multiple myeloma tumor cells are selectively killed by pharmacologically-dosed ascorbic acid.Mar 31, 2017

Myricetin effectively represses the malignant progression of prostate cancer.Jul 24, 2018

Oral administration of dandelion root extract inhibited the growth of human colon xenograft models by more than 90%.Aug 21, 2016

Piperlongumine a promising potential candidate for use as a therapeutic option for patients with PHEO/PGL and SDHB mutations.May 25, 2016

Piperlongumine-induced nuclear translocation of the FOXO3A transcription factor triggers BIM-mediated apoptosis in cancer cells.Apr 30, 2019