Wrinkles

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8 Diseases Researched for Wrinkles
NameACCKFocus
Wrinkles37318Locked
Aging Skin31277Locked
Ultraviolet Radiation Induced Damage314Locked
Melasma110Locked
Skin Diseases: Photo-Aging110Locked
Wound Healing13Locked
Hydrogen Peroxide Induced Toxicity11Locked
Oxidative Stress11Locked
26 Substances Researched for Wrinkles
NameACCKFocus
Almond220Locked
Gotu Kola120Locked
Cocoa418Locked
Cordyceps sinensis115Locked
Mushrooms: All 115Locked
Amla Fruit212Locked
Aloe Vera110Locked
Chicken extract110Locked
Dates110Locked
Fig110Locked
Fish110Locked
Fish Oil110Locked
Flavonoids110Locked
Ginkgo biloba110Locked
Hydrangea110Locked
Lingonberry110Locked
Orange: Mandarin110Locked
Pomegranate110Locked
Rose 110Locked
Rutin110Locked
White Mulberry 110Locked
Barley12Locked
Phlorotannins12Locked
Ginseng11Locked
Lactobacillus Brevis11Locked
Peppermint11Locked
5 Therapeutic Actions Researched for Wrinkles
NameACCKFocus
Photobiomodulation983Locked
Light Therapy: Red Colored550Locked
Electroacupuncture110Locked
Infrared Light110Locked
Sunlight exposure12Locked
12 Pharmacological Actions Researched for Wrinkles
NameACCKFocus
Antioxidants638Locked
Photoprotective632Locked
Matrix metalloproteinase-1 (MMP-1) inhibitor220Locked
Anti-Apoptotic110Locked
Anti-collagenase110Locked
MicroRNA modulator110Locked
Catalase Up-Regulation11Locked
Enzyme Inhibitors11Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor11Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor11Locked
Superoxide Dismutase Up-regulation11Locked
Tyrosinase Inhibition11Locked

View the Evidence:
37 Abstracts with Wrinkles Research

[+]

Efficacy and safety of Centella Asiatica on wrinkles.Oct 31, 2020

Pubmed Data : J Cosmet Sci. 2020 Nov-Dec;71(6):439-454. PMID: 33413787
Article Published Date : Oct 31, 2020
Study Type : Meta Analysis, Review
Additional Links
Substances : Gotu Kola
Diseases : Wrinkles
[+]

A study of facial wrinkles improvement effect of veratric acid from cauliflower mushroom.Mar 31, 2016

Pubmed Data : Arch Dermatol Res. 2016 Apr ;308(3):183-92. Epub 2016 Feb 25. PMID: 26914455
Article Published Date : Mar 31, 2016
Study Type : Human In Vitro, Human Study
Additional Links
Substances : Mushrooms: All
Diseases : Aging Skin, Wrinkles
Pharmacological Actions : Photoprotective
[+]

NAD-driven sirtuin activation by Cordyceps sinensis extract: exploring the adaptogenic aotential to promote skin longevity.Apr 11, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2024 Apr 12 ;25(8). Epub 2024 Apr 12. PMID: 38673866
Article Published Date : Apr 11, 2024
Study Type : Human In Vitro, Human Study
Additional Links
Substances : Cordyceps sinensis
Diseases : Aging Skin, Wrinkles
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts
[+]

A study to determine the efficacy of a novel handheld light-emitting diode device in the treatment of photoaged skin.Nov 30, 2008

Pubmed Data : J Cosmet Dermatol. 2008 Dec ;7(4):263-7. PMID: 19146602
Article Published Date : Nov 30, 2008
Study Type : Human Study
Additional Links
Diseases : Aging Skin, Wrinkles
Therapeutic Actions : Photobiomodulation
[+]

Aloe gel significantly improves wrinkles and elasticity in photoaged human skin.Feb 01, 2009

Pubmed Data : Ann Dermatol. 2009 Feb;21(1):6-11. Epub 2009 Feb 28. PMID: 20548848
Article Published Date : Feb 01, 2009
Study Type : Human Study
Additional Links
Substances : Aloe Vera
Diseases : Aging Skin, Skin Diseases: Photo-Aging, Wrinkles
Pharmacological Actions : Matrix metalloproteinase-1 (MMP-1) inhibitor
[+]

Anti-wrinkle and skin moisture efficacy of 7-MEGA.Jan 08, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2024 Jan 9 ;16(2). Epub 2024 Jan 9. PMID: 38257104
Article Published Date : Jan 08, 2024
Study Type : Human Study
Additional Links
Substances : Fish Oil
Diseases : Aging Skin, Wrinkles
[+]

Assessment of the effect of extract formulation of date palm kernel on facial skin wrinkles.Dec 31, 2018

Pubmed Data : J Cosmet Sci. 2019 Nov/Dec;70(6):277-290. PMID: 31829921
Article Published Date : Dec 31, 2018
Study Type : Human Study
Additional Links
Substances : Dates
Diseases : Aging Skin, Wrinkles
Additional Keywords : Plant Extracts
[+]

Biological effects of rutin on skin aging.Jun 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2016 Jul ;38(1):357-63. Epub 2016 May 24. PMID: 27220601
Article Published Date : Jun 30, 2016
Study Type : Human Study
Additional Links
Substances : Rutin
Diseases : Aging Skin, Wrinkles
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Matrix metalloproteinase-1 (MMP-1) inhibitor, MicroRNA modulator
[+]

Daily almond consumption may reduce wrinkle severity in postmenopausal females to potentially have natural anti-aging benefits.Sep 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Phytother Res. 2019 Oct 1. Epub 2019 Oct 1. PMID: 31576607
Article Published Date : Sep 30, 2019
Study Type : Human Study
Additional Links
Substances : Almond
Diseases : Aging Skin, Wrinkles
[+]

Effects of radiofrequency, electroacupuncture, and low-level laser therapy on the wrinkles and moisture content of the forehead, eyes, and cheek.Jan 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Phys Ther Sci. 2017 Feb ;29(2):290-294. Epub 2017 Feb 24. PMID: 28265160
Article Published Date : Jan 31, 2017
Study Type : Human Study
Additional Links
Diseases : Aging Skin, Wrinkles
Therapeutic Actions : Electroacupuncture, Photobiomodulation
[+]

Green mandarins effectively improves UV-induced skin wrinkles.Mar 23, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2022 Mar 24 ;14(7). Epub 2022 Mar 24. PMID: 35405965
Article Published Date : Mar 23, 2022
Study Type : Human Study
Additional Links
Substances : Orange: Mandarin
Diseases : Aging Skin, Ultraviolet Radiation Induced Damage, Wrinkles
Pharmacological Actions : Photoprotective
Additional Keywords : Plant Extracts
[+]

Hot water extract of Hydrangea serrata leaves could be used as a health supplement for skin anti-aging.May 27, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 May 28 ;12(6). Epub 2020 May 28. PMID: 32481760
Article Published Date : May 27, 2020
Study Type : Human Study
Additional Links
Substances : Hydrangea
Diseases : Aging Skin, Wrinkles
[+]

In moderately photo-aged women, regular cocoa flavanol consumption had positive effects on facial wrinkles and elasticity.Nov 17, 2015

Pubmed Data : J Nutr. 2015 Nov 18. Epub 2015 Nov 18. PMID: 26581682
Article Published Date : Nov 17, 2015
Study Type : Human Study
Additional Links
Substances : Cocoa
Diseases : Wrinkles
[+]

Low-level laser therapy for skin rejuvenation: A safe and effective solution baked by data and visual evidence.May 29, 2024

Pubmed Data : J Cosmet Dermatol. 2024 May 30. Epub 2024 May 30. PMID: 38817003
Article Published Date : May 29, 2024
Study Type : Human Study
Additional Links
Diseases : Aging Skin, Melasma, Wrinkles
Therapeutic Actions : Photobiomodulation
[+]

Low-level light therapy using 660 nm LEDs or 411 to 777 nm LEDs significantly improved periocular wrinkles.Feb 28, 2017

Pubmed Data : Dermatol Surg. 2017 Mar ;43(3):371-380. PMID: 28195844
Article Published Date : Feb 28, 2017
Study Type : Human Study
Additional Links
Diseases : Aging Skin, Wrinkles
Therapeutic Actions : Light Therapy: Red Colored, Photobiomodulation
[+]

Male facial rejuvenation using a combination 633, 830, and 1072 nm LED face mask.Oct 31, 2023

Pubmed Data : Arch Dermatol Res. 2023 Nov ;315(9):2605-2611. Epub 2023 Jul 7. PMID: 37418018
Article Published Date : Oct 31, 2023
Study Type : Human Study
Additional Links
Diseases : Aging Skin, Wrinkles
Therapeutic Actions : Infrared Light, Light Therapy: Red Colored
[+]

Novel hydrolyzed chicken sternal cartilage extract improves facial epidermis and connective tissue in healthy adult females.Aug 31, 2019

Pubmed Data : Altern Ther Health Med. 2019 Sep ;25(5):12-29. PMID: 31221944
Article Published Date : Aug 31, 2019
Study Type : Human Study
Additional Links
Substances : Chicken extract
Diseases : Aging Skin, Wrinkles
[+]

Oral consumption of Bonito fish-derived elastin peptide (VGPG Elastin® ) improves biophysical properties in aging skin.Feb 29, 2024

Pubmed Data : Skin Res Technol. 2024 Mar ;30(3):e13634. PMID: 38481080
Article Published Date : Feb 29, 2024
Study Type : Human Study
Additional Links
Substances : Fish
Diseases : Aging Skin, Wrinkles
[+]

Oral intake of lingonberry and amla fruit extract improves skin conditions in healthy female subjects.Aug 31, 2019

Pubmed Data : Biotechnol Appl Biochem. 2019 Sep ;66(5):870-879. Epub 2019 Aug 16. PMID: 31342566
Article Published Date : Aug 31, 2019
Study Type : Human Study
Additional Links
Substances : Amla Fruit, Lingonberry
Diseases : Aging Skin, Wrinkles
Additional Keywords : Plant Extracts
[+]

Photobiomodulation reduces periocular wrinkle volume by 30%Jan 31, 2023

Pubmed Data : Photobiomodul Photomed Laser Surg. 2023 Feb ;41(2):48-56. PMID: 36780572
Article Published Date : Jan 31, 2023
Study Type : Human Study
Additional Links
Diseases : Aging Skin, Wrinkles
Therapeutic Actions : Light Therapy: Red Colored, Photobiomodulation
[+]

Pycnogenol supplementation benefits human skin by increasing skin hydration and skin elasticity. Dec 31, 2011

Pubmed Data : Skin Pharmacol Physiol. 2012 ;25(2):86-92. Epub 2012 Jan 21. PMID: 22270036
Article Published Date : Dec 31, 2011
Study Type : Human Study
Additional Links
Substances : Flavonoids
Diseases : Aging Skin, Wrinkles
[+]

Safety and efficacy of a novel home-use device for light-potentiated (LED) skin treatment.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biophotonics. 2020 Dec ;13(12):e202000230. Epub 2020 Oct 5. PMID: 32949447
Article Published Date : Nov 30, 2020
Study Type : Human Study
Additional Links
Diseases : Aging Skin, Wrinkles
Therapeutic Actions : Light Therapy: Red Colored, Photobiomodulation
[+]

Safety, efficacy, and usage compliance of home-use device utilizing RF and light energies for treating periorbital wrinkles.Feb 28, 2017

Pubmed Data : J Cosmet Dermatol. 2017 Mar ;16(1):95-102. Epub 2016 Dec 2. PMID: 27910259
Article Published Date : Feb 28, 2017
Study Type : Human Study
Additional Links
Diseases : Aging Skin, Wrinkles
Therapeutic Actions : Photobiomodulation
[+]

The combined formulation of fruit extracts showed excellent antioxidative and anti-collagenase activity as well as a significant effect on anti-wrinkle activity on human skin.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Cosmet Investig Dermatol. 2015 ;8:389-96. Epub 2015 Jul 16. PMID: 26203268
Article Published Date : Dec 31, 2014
Study Type : Human Study, In Vitro Study
Additional Links
Substances : Fig, Ginkgo biloba, Pomegranate, White Mulberry
Diseases : Aging Skin, Wrinkles
Pharmacological Actions : Anti-collagenase, Antioxidants
Additional Keywords : Dose Response, Natural Substances Versus Drugs, Plant Extracts
[+]

The daily consumption of almonds may improve several aspects of photoaging such as facial wrinkles and pigment intensity in postmenopausal women.Feb 26, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2021 Feb 27 ;13(3). Epub 2021 Feb 27. PMID: 33673587
Article Published Date : Feb 26, 2021
Study Type : Human Study
Additional Links
Substances : Almond
Diseases : Aging Skin, Wrinkles
[+]

The effectiveness of a standardized rose hip powder, containing seeds and shells of Rosa canina, on cell longevity, skin wrinkles, moisture, and elasticity.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Interv Aging. 2015 ;10:1849-56. Epub 2015 Nov 19. PMID: 26604725
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Substances : Rose
Diseases : Aging Skin, Wrinkles
[+]

The efficacy of red and near-infrared light treatment in patient satisfaction, reduction of fine lines, wrinkles, skin roughness, and intradermal collagen density increase.Jan 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Photomed Laser Surg. 2014 Feb ;32(2):93-100. Epub 2013 Nov 28. PMID: 24286286
Article Published Date : Jan 31, 2014
Study Type : Human Study
Additional Links
Diseases : Aging Skin, Wrinkles
Therapeutic Actions : Light Therapy: Red Colored
Additional Keywords : Skin Rejuvenation
[+]

The use of light-emitting diode therapy in the treatment of photoaged skin.Aug 31, 2007

Pubmed Data : J Cosmet Dermatol. 2007 Sep ;6(3):189-94. PMID: 17760698
Article Published Date : Aug 31, 2007
Study Type : Human Study
Additional Links
Diseases : Aging Skin, Wrinkles
Therapeutic Actions : Photobiomodulation
[+]

Cocoa pod extracts help to reduce wrinkles on skin after 3 weeks of application.Apr 03, 2016

Pubmed Data : J Cosmet Dermatol. 2016 Apr 4. Epub 2016 Apr 4. PMID: 27041391
Article Published Date : Apr 03, 2016
Study Type : Human In Vitro
Additional Links
Substances : Cocoa
Diseases : Wrinkles
Additional Keywords : Plant Extracts
[+]

Exploring the safety and efficacy of organic light-emitting diode in skin rejuvenation and wound healing.Jan 31, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Yonsei Med J. 2024 Feb ;65(2):98-107. PMID: 38288650
Article Published Date : Jan 31, 2024
Study Type : Animal Study, In Vitro Study
Additional Links
Diseases : Wound Healing, Wrinkles
Therapeutic Actions : Photobiomodulation
[+]

Cacao extract may offer a protective effects against photo-aging.Feb 04, 2016

Pubmed Data : J Invest Dermatol. 2016 Feb 5. Epub 2016 Feb 5. PMID: 26854493
Article Published Date : Feb 04, 2016
Study Type : Animal Study
Additional Links
Substances : Cocoa
Diseases : Aging Skin, Ultraviolet Radiation Induced Damage, Wrinkles
Pharmacological Actions : Photoprotective
Additional Keywords : Plant Extracts
[+]

Dieckol isolated from Eisenia bicyclis ameliorates wrinkling and improves skin hydration.Dec 13, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mar Drugs. 2022 Dec 14 ;20(12). Epub 2022 Dec 14. PMID: 36547926
Article Published Date : Dec 13, 2022
Study Type : Animal Study
Additional Links
Substances : Phlorotannins
Diseases : Aging Skin, Wrinkles
Therapeutic Actions : Sunlight exposure
Pharmacological Actions : Photoprotective
[+]

Indian gooseberry and barley sprout complex prevent oxidative stress and photoaging of the skin.Apr 04, 2024

Pubmed Data : J Med Food. 2024 Apr 5. Epub 2024 Apr 5. PMID: 38579153
Article Published Date : Apr 04, 2024
Study Type : Animal Study
Additional Links
Substances : Amla Fruit, Barley
Diseases : Ultraviolet Radiation Induced Damage, Wrinkles
Pharmacological Actions : Photoprotective
[+]

Anti‑wrinkle effect of fermented black ginseng on human fibroblasts.Feb 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2017 Mar ;39(3):681-686. Epub 2017 Jan 16. PMID: 28098856
Article Published Date : Feb 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Ginseng
Diseases : Aging Skin, Wrinkles
Pharmacological Actions : Antioxidants, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords : Plant Extracts
[+]

Cocoa pod extract has high potential as a cosmetic ingredient due to its anti-wrinkle, skin whitening, and sunscreen effects.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2014 ;14:381. Epub 2014 Oct 7. PMID: 25292439
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Cocoa
Diseases : Aging Skin, Wrinkles
Pharmacological Actions : Antioxidants, Enzyme Inhibitors, Photoprotective, Tyrosinase Inhibition
Additional Keywords : Plant Extracts
[+]

Mentha piperita leaf extract suppresses the release of ATP from epidermal keratinocytes and reduces dermal thinning as well as wrinkle formation.Jul 24, 2024

Pubmed Data : Int J Cosmet Sci. 2024 Jul 25. Epub 2024 Jul 25. PMID: 39049707
Article Published Date : Jul 24, 2024
Study Type : In Vitro Study
Additional Links
Substances : Peppermint
Diseases : Aging Skin, Wrinkles
[+]

These results suggest the possibility of utilizing Levilactobacillus brevis BK3 as a functional ingredient with antioxidant and wrinkle-improving effects.Jul 27, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Microbiol Biotechnol. 2024 Jul 28 ;34(7):1401-1409. Epub 2024 May 24. PMID: 38881180
Article Published Date : Jul 27, 2024
Study Type : In Vitro Study
Additional Links
Substances : Lactobacillus Brevis
Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress, Wrinkles
Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Superoxide Dismutase Up-regulation

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