Angiogenesis Inhibitors

Name	AC	CK
Ginsenosides	23	69
Curcumin	23	29
Cannabinoids	12	25
EGCG (Epigallocatechin gallate)	12	18
Melatonin	11	17
Resveratrol	13	16
Flavonoids	11	15
Delta-tetrahydrocannabinol (THC)	4	14
Quercetin	10	14
Tanshinone IIA	11	13
Thymoquinone	9	13
Diosmin	2	11
Fucoidan	9	11
Cannabidiol	8	10
Polyphenols	5	10
Vitamin C: Intravenous	1	10
Berberine	7	9
Genistein	7	9
Ginkgo biloba	5	8
Nobiletin	7	8
Baicalein	4	7
Emodin	4	7
Gold (nanoparticles)	5	7
Huaier (Trametes robiniophila murr)	6	7
Luteolin	6	7
Palmitoylethanolamide	4	7
Honokiol	6	6
Mangiferin	4	6
Myricetin	4	6
Nigella sativa (aka Black Seed)	5	6
Panax Notoginseng	4	6
Silibinin	5	6
Xanthohumol	4	6
Zerumbone	4	6
Apple Polyphenols	1	5
Bee Venom	3	5
Cucurbitacin B	4	5
Deguelin	4	5
Fenugreek	3	5
Icariin	2	5
Neem	4	5
Prunella vulgaris	3	5
Rice	1	5
Sesamin	2	5
Tetrahydrocurcumin	3	5
Zataria multiflora	1	5
Apigenin	4	4
Astaxanthin	2	4
Beta Sitosterol	2	4
Cannabis	4	4
Celastrol	3	4
Crocetin	3	4
Crocin	3	4
Fisetin	3	4
Garlic	3	4
Indole-3-Carbinol	3	4
Isoflavones	3	4
Lotus	3	4
Oridonin	2	4
Phloretin	3	4
Pomegranate	3	4
Vitamin E	3	4
Wogonin	3	4
Anthocyanins	3	3
Arctigenin	2	3
Asiatic Acid	2	3
Astragaloside	2	3
Banana	2	3
Beet	2	3
Cannabinoids: Synthetic	2	3
Chrysin	1	3
Citrus Triterpenoids	1	3
D-Limonene	2	3
Fucoxanthin	3	3
Ginseng	2	3
Goji	2	3
Green Tea	2	3
Lactoferrin	2	3
Lycopene	2	3
Mango	1	3
NAC (N-acetyl-L-cysteine)	2	3
Naringenin	3	3
Onion	2	3
Parthenolide	2	3
Piceatannol	2	3
Piperine	3	3
Sulforaphane	2	3
Vitamin D	3	3
Aloe Vera	1	2
Amygdalin	1	2
Andrographolide	2	2
Bee Propolis	1	2
Betaine	1	2
Black Pepper	1	2
Burdock	2	2
Caffeic acid phenethyl ester	2	2
Carotenoids	2	2
Carvacrol	1	2
Chamomile	2	2
Curcumol	2	2
Curry Leaves	1	2
Daidzein	1	2
Echinacea	2	2
Ellagic Acid	1	2
Formononetin	1	2
Geraniol	1	2
Ginger	2	2
Hesperidin	1	2
Holy Basil	2	2
Hops	2	2
Hydrogen Water	1	2
Isothiocyanates	1	2
Kaempferol	2	2
Krill	1	2
Lemon	1	2
Lemon Balm	1	2
Lupeol	1	2
Lychee	1	2
Maitake Mushroom	1	2
Miracle Fruit	1	2
Mulberry	1	2
Oleanolic acid	1	2
Oleuropein	1	2
Paeoniflorin	2	2
Palash	1	2
Phlorotannins	1	2
Phyllanthus amarus	2	2
Phyllanthus niruri (Stonebreaker)	2	2
Phyllanthus urinaria	2	2
Piperlongumine	1	2
Proanthocyanidins	2	2
Procyanidin B2	2	2
Punicalagin	2	2
Red Clover	1	2
Reishi Mushroom	2	2
Rosemaric Acid	1	2
Salvia miltiorrhiza	2	2
Seaweed	2	2
Seaweed: Brown	2	2
Shark Cartilage	1	2
Shiitake Mushroom	1	2
Soy Protein	1	2
Spirulina	1	2
Stigmasterol	1	2
Thuja	1	2
Tocotrienol: Delta	1	2
Tomato	1	2
Traditional Chinese Medicine: Mylabris	1	2
Turmeric	2	2
Ursolic Acid	1	2
Velvet antler	1	2
Viruses: Beneficial	1	2
Vitamin B-3 (Niacin)	1	2
Vitamin K2	1	2
Yerba Santa	1	2
6-Shogaol	1	1
Allicin	1	1
Andrographis	1	1
Ashwagandha	1	1
Barberry	1	1
Berbamine	1	1
Beta-Caryophyllene	1	1
Beta-Elemene	1	1
Beta-glucan	1	1
Betulinic acid	1	1
Bitter Apple	1	1
Bitter Melon	1	1
Black Cohosh	1	1
Black Tea	1	1
Blueberry	1	1
Bufalin	1	1
Capsaicin	1	1
Catechin	1	1
Chinese Skullcap	1	1
Chlorogenic Acid	1	1
Cinnamon	1	1
Cissus quadrangularis	1	1
Citrus Peel	1	1
Citrus naringin	1	1
Cocoa	1	1
Coptidis rhizoma	1	1
Cordyceps Militaris	1	1
Cordyceps sinensis	1	1
Cranberry	1	1
Cruciferous Vegetables	1	1
Curcuminoids	1	1
Cyanidin 3-glucoside	1	1
DHA (Docosahexaenoic Acid)	1	1
Dandelion	1	1
Delphinidin	1	1
Demethoxycurcumin	1	1
Endocannabinoids	1	1
Epimedium	1	1
Eugenol	1	1
Fiber	1	1
Flaxseed	1	1
Folate	1	1
Fruit: All	1	1
Gallic Acid	1	1
Garcinia hanburyi	1	1
Geum japonicum	1	1
Grape	1	1
Harmine	1	1
Hazelnut	1	1
Hibiscus sabdariffa	1	1
Horse Chestnut	1	1
Hydrangea	1	1
Isoliquiritigenin	1	1
Isothiocyanate	1	1
Jujube	1	1
Lactobacillus rhamnosus GG	1	1
Licorice	1	1
Ligustrazine	1	1
Magnolol	1	1
Manuka Honey	1	1
Moringa oleifera	1	1
Noni	1	1
Nordihydroguaiaretic acid (NDGA)	1	1
Olive	1	1
Olive Oil	1	1
Olive leaf extract	1	1
Omega-3 Fatty Acids	1	1
Orthosiphon	1	1
Paeonol	1	1
Passion Flower	1	1
Persimmon	1	1
Poria cocos	1	1
Probiotics	1	1
Propolis: Bee	1	1
Pterostilbene	1	1
Radish	1	1
Safflower	1	1
Selenium	1	1
Shikonin	1	1
Silver (nanoparticles)	1	1
Spinach	1	1
Tangeretin	1	1
Tannic Acid	1	1
Tualang Honey	1	1
Ume (Japanese apricot)	1	1
Verbascoside	1	1
Vitamin A	1	1
Vitamin C	1	1
Walnut	1	1
Wormwood	1	1

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Pubmed Data : Int J Biol Macromol. 2015 Apr ;75:115-20. Epub 2015 Jan 15. PMID: 25597429

Article Published Date : Mar 31, 2015

Study Type : Animal Study, In Vitro Study

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Substances : Huaier (Trametes robiniophila murr)

Diseases : Liver Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Apoptotic, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Vascular Endothelial Growth Factor Inhibitors

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A novel GP73-regulated oncolytic adenovirus may virtually represent an attractive therapeutic agent for targeting liver CSCs.May 16, 2016

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Pubmed Data : Melanoma Res. 2019 Oct 22. Epub 2019 Oct 22. PMID: 31651714

Article Published Date : Oct 21, 2019

Study Type : Animal Study, In Vitro Study

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Substances : Mangiferin

Diseases : Melanoma: Metastasis

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Anti-metastatic, Interferon Gamma Reducer, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Antitumor activity of ginsenoside Rg3 in melanoma through downregulation of the ERK and Akt pathways.May 31, 2019

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Pubmed Data : J Cell Mol Med. 2021 May 3. Epub 2021 May 3. PMID: 33939310

Article Published Date : May 02, 2021

Study Type : Animal Study

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Substances : Baicalein

Diseases : Osteoarthritis

Pharmacological Actions : Angiogenesis Inhibitors, Osteoprotective

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Baicalein might be an alternative treatment against refractory chronic inflammation.Nov 25, 2016

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Pubmed Data : FASEB J. 2006 Dec ;20(14):2633-5. Epub 2006 Oct 25. PMID: 17065222

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Pubmed Data : Int J Biol Macromol. 2020 Jan 28 ;149:600-608. Epub 2020 Jan 28. PMID: 32004612

Article Published Date : Jan 27, 2020

Study Type : Animal Study, In Vitro Study

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Substances : Fucoidan

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, NF-kappaB Inhibitor

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Pubmed Data : Int J Oncol. 2018 Jan ;52(1):127-138. Epub 2017 Nov 1. PMID: 29115601

Article Published Date : Dec 31, 2017

Study Type : Animal Study, In Vitro Study

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Substances : Ginsenosides

Diseases : Colorectal Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative

Additional Keywords : Cancer Stem Cells, Chemothapeutic Synergy: 5-flourouracil, Chemotherapeutic Synergy: Oxaliplatin

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Glabridin inhibits migration, invasion, and angiogenesis of human non-small cell lung cancer A549 cells.Nov 30, 2011

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Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:610-620. Epub 2018 Nov 3. PMID: 30399598

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Bee Propolis

Diseases : Alcohol Toxicity , Inflammation

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Identification of phenolics from miracle berry leaf extract and its antiangiogenesis and anticancer activities.Dec 31, 2021

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Pubmed Data : BMC Cancer. 2009 Jul 23 ;9:250. Epub 2009 Jul 23. PMID: 19624862

Article Published Date : Jul 22, 2009

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Lung Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Chemotherapeutic Synergy: Gemcitabine

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Krill oil supplementation reduces the growth of CT-26 orthotopic tumours.Feb 03, 2022

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Pubmed Data : Anticancer Agents Med Chem. 2016 May 20. Epub 2016 May 20. PMID: 27198988

Nimbolide inhibits 2D and 3D prostate cancer cells migration, affects microtubules and angiogenesis.Dec 31, 2021

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Pubmed Data : Phytomedicine. 2022 Jan ;94:153826. Epub 2021 Nov 1. PMID: 34775358

Article Published Date : Dec 31, 2021

Study Type : Animal Study

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Substances : Neem

Diseases : Prostate Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antiproliferative

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Norcantharidin, a compound found within the traditional Chinese medicine Mylabris, has an anti-angiogenic activity in human gallbladder cancer cells.Mar 14, 2006

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Pubmed Data : Zhonghua Yi Xue Za Zhi. 2006 Mar 14;86(10):693-9. PMID: 16681930

Article Published Date : Mar 14, 2006

Study Type : Animal Study

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Substances : Traditional Chinese Medicine: Mylabris

Diseases : Gallbladder Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Angiogenic, Apoptotic, Vascular Endothelial Growth Factor A Inhibitor

Additional Keywords : Drug: 5-flourouracil

[+]

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Pubmed Data : Eur J Pharmacol. 2016 Nov 15 ;791:669-674. Epub 2016 Oct 5. PMID: 27720681

Article Published Date : Nov 14, 2016

Study Type : Animal Study

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Substances : Palmitoylethanolamide

Diseases : Dermatitis: Contact, Inflammation

Pharmacological Actions : Angiogenesis Inhibitors

[+]

Panax notoginseng saponins prevent bone loss by promoting angiogenesis in an osteoporotic mouse model.Dec 31, 2019

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Protective effects of lycium barbarum polysaccharides on blood-retinal barrier via ROCK1 pathway in diabetic rats.Dec 31, 2018

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Pubmed Data : Am J Transl Res. 2019 ;11(10):6304-6315. Epub 2019 Oct 15. PMID: 31737184

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Goji

Diseases : Diabetic Complications, Diabetic Retinopathy

Pharmacological Actions : Angiogenesis Inhibitors, Cytoprotective

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Punica granatum pericarp extract suppressed tumor proliferation and angiogenesis in a model of melanoma.Dec 31, 2018

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Pubmed Data : Biomedicines. 2023 Jan 11 ;11(1). Epub 2023 Jan 11. PMID: 36672695

Article Published Date : Jan 10, 2023

Study Type : Animal Study

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Substances : Sesamin

Diseases : Cancers: All

Pharmacological Actions : Angiogenesis Inhibitors

[+]

Sika deer (Cervus nippon) velvet antler extract attenuates prostate cancer in xenograft model.Jan 31, 2019

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Pubmed Data : BMC Complement Altern Med. 2013 ;13:144. Epub 2013 Jun 24. PMID: 23800091

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Pubmed Data : PLoS One. 2013 ;8(1):e54795. Epub 2013 Jan 22. PMID: 23349970

Article Published Date : Dec 31, 2012

Study Type : Animal Study

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Substances : Cannabidiol, Cannabinoids , Delta-tetrahydrocannabinol (THC)

Diseases : Glioblastoma Multiforme

Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Apoptotic

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The inhibitory effect of Ginkgo biloba exocarp extracts on the growth of B16 melanoma transplant tumor in mice is related to inhibiting angiogenesis.Dec 31, 2018

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A narrative review of the pharmacology of ginsenoside compound K.Jan 31, 2022

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Pubmed Data : Ann Transl Med. 2022 Feb ;10(4):234. PMID: 35280413

Article Published Date : Jan 31, 2022

Study Type : Review

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Substances : Ginsenosides

Diseases : Allergies, Cancers: All, Inflammation

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Allergic Agents, Anti-Inflammatory Agents, Hepatoprotective, Neuroprotective Agents

[+]

A network pharmacology approach to reveal the underlying mechanisms of Artemisia annua on the treatment of hepatocellular carcinoma.Dec 31, 2020

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Pubmed Data : Mar Drugs. 2015 Apr ;13(4):2327-46. Epub 2015 Apr 14. PMID: 25874926

Article Published Date : Mar 31, 2015

Study Type : Review

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Substances : Fucoidan, Seaweed: Brown

Diseases : Cancers: All

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Anticarcinogenic Agents, Apoptotic, Cell cycle arrest

Additional Keywords : Natural Substance/Drug Synergy

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A review of recent applications of curcumin as anti-invasive and antimetastatic agent in in vitro and in vivo and ex vivo studies as well as associated molecular mechanisms.Dec 31, 2013

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Adjuvant role of Salvia miltiorrhiza bunge in cancer chemotherapy.Aug 09, 2023

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Pubmed Data : J Ethnopharmacol. 2023 Aug 10 ;318(Pt B):117022. Epub 2023 Aug 10. PMID: 37572929

Article Published Date : Aug 09, 2023

Study Type : Review

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Substances : Salvia miltiorrhiza

Diseases : Lung Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antiproliferative , Apoptotic, Autophagy Up-regulation, Chemotherapeutic

Additional Keywords : Tumor Microenvironment

[+]

Advances in the medical treatment of adolescent endometriosis.May 31, 2023

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Pubmed Data : Minerva Pediatr (Torino). 2023 Jun ;75(3):423-431. Epub 2021 Jul 26. PMID: 34309341

Article Published Date : May 31, 2023

Study Type : Review

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Substances : Curcumin, Melatonin, Vitamin D

Diseases : Dysmenorrhea, Endometriosis

Pharmacological Actions : Angiogenesis Inhibitors

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Anti-cancer effect of spinach glycoglycerolipids as angiogenesis inhibitors.Dec 31, 2010

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Pubmed Data : Molecules. 2024 Apr 18 ;29(8). Epub 2024 Apr 18. PMID: 38675663

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Pubmed Data : Eur J Pharmacol. 2022 Feb 5 ;916:174699. Epub 2021 Dec 14. PMID: 34919888

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Pubmed Data : Food Chem Toxicol. 2022 Aug 22:113385. Epub 2022 Aug 22. PMID: 36007853

Article Published Date : Aug 21, 2022

Study Type : Review

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Substances : Apigenin

Diseases : Cancers: All

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Apoptotic, Autophagy Inhibitors, Cell cycle arrest, Immunomodulatory

[+]

Apigenin inhibits angiogenesis in retinal microvascular endothelial cells.Jul 05, 2023

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Pubmed Data : BMC Ophthalmol. 2023 Jul 6 ;23(1):302. Epub 2023 Jul 6. PMID: 37415101

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Pubmed Data : Pharmacol Res. 2023 Dec 5 ;199:107032. Epub 2023 Dec 5. PMID: 38061594

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Pubmed Data : Food Sci Nutr. 2021 Nov ;9(11):6406-6420. Epub 2021 Sep 9. PMID: 34760270

Article Published Date : Oct 31, 2021

Study Type : Review

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Substances : Beet

Diseases : Cancers: All, Chronic Disease, Hypertension

Pharmacological Actions : Angiogenesis Inhibitors, Antihypertensive Agents, Antioxidants, Antiproliferative , Apoptotic, Hypoglycemic Agents, Hypolipidemic

[+]

Berberine exerts anti-cancer activity by modulating adenosine monophosphate-activated protein kinase.Sep 27, 2020

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Pubmed Data : Curr Pharm Des. 2020 Sep 28. Epub 2020 Sep 28. PMID: 32988344

Article Published Date : Sep 27, 2020

Study Type : In Vitro Study

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Substances : Berberine

Diseases : Cancers: All

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antiproliferative

[+]

Berberine: An inspiring resource for the treatment of colorectal diseases.Sep 24, 2023

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Pubmed Data : Biomed Pharmacother. 2023 Jul ;163:114882. Epub 2023 May 15. PMID: 37196541

Article Published Date : Jun 30, 2023

Study Type : Review

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Substances : Celastrol

Diseases : Cancers: All

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antineoplastic Agents, Antiproliferative , Apoptotic

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Pubmed Data : Phytother Res. 2019 Jan ;33(1):81-89. Epub 2018 Sep 25. PMID: 30251280

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

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Substances : Cyanidin 3-glucoside

Diseases : Breast Cancer

Pharmacological Actions : Angiogenesis Inhibitors, MicroRNA modulator, STAT3 Inhibitor, Vascular Endothelial Growth Factor Inhibitors

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D-limonene rich volatile oil from blood oranges inhibits angiogenesis, metastasis and cell death in human colon cancer cells.Oct 04, 2012

Pubmed Data : Toxicol Appl Pharmacol. 2022 Jan 21 ;437:115889. Epub 2022 Jan 21. PMID: 35065992

Article Published Date : Jan 20, 2022

Study Type : In Vitro Study

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Substances : Quercetin

Diseases : Liver Cancer

Pharmacological Actions : Angiogenesis Inhibitors

[+]

Dietary factors modify miRNA expression and their mRNA targets in various cancer processes.Oct 31, 2011

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Pubmed Data : Adv Nutr. 2011 Nov ;2(6):472-85. Epub 2011 Nov 3. PMID: 22332090

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Pubmed Data : Biomolecules. 2023 Feb 7 ;13(2). Epub 2023 Feb 7. PMID: 36830684

Article Published Date : Feb 06, 2023

Study Type : Review

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Substances : Horse Chestnut

Diseases : Cancers: All

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Anti-metastatic, Apoptotic

Additional Keywords : Plant Extracts

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Exploring molecular targets in cancer: Unveiling the anticancer potential of Paeoniflorin.Dec 31, 2023

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Pubmed Data : Oncol Lett. 2020 Aug ;20(2):1239-1244. Epub 2020 May 28. PMID: 32724364

Article Published Date : Jul 31, 2020

Study Type : In Vitro Study

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Substances : Fisetin

Diseases : Retinoblastoma

Pharmacological Actions : Angiogenesis Inhibitors, Vascular Endothelial Growth Factor Inhibitors

[+]

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Pubmed Data : J Tradit Complement Med. 2018 Apr ;8(2):278-281. Epub 2017 Apr 25. PMID: 29736382

Article Published Date : Mar 31, 2018

Study Type : In Vitro Study

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Substances : Genistein

Diseases : Endometriosis

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Superiority of Natural Substances versus Drugs

Problem Substances : Leuprorelin (Lupron)

[+]

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Pubmed Data : Mol Nutr Food Res. 2011 Feb ;55(2):318-27. PMID: 20626003

Article Published Date : Jan 31, 2011

Study Type : In Vitro Study

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Substances : Isoflavones, Licorice

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic

[+]

Gold nanoparticles disrupt tumor microenvironment.Jun 18, 2019

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Pubmed Data : Bioconjug Chem. 2019 Jun 19 ;30(6):1724-1733. Epub 2019 May 22. PMID: 31067032

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Pubmed Data : Biosci Rep. 2019 May 31 ;39(5). Epub 2019 May 2. PMID: 30910851

Article Published Date : May 30, 2019

Study Type : In Vitro Study

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Substances : Harmine

Diseases : Bladder Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Apoptotic, Vascular Endothelial Growth Factor Inhibitors

[+]

Honokiol could enhancing the anti-glioma therapy of doxorubicin.Feb 26, 2017

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Pubmed Data : Sci Rep. 2017 Feb 27 ;7:43501. Epub 2017 Feb 27. PMID: 28240249

Article Published Date : Feb 26, 2017

Study Type : In Vitro Study

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Substances : Honokiol

Diseases : Glioma

Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Chemotherapeutic

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

[+]

Honokiol inhibits interleukin-induced angiogenesis in the NSCLC microenvironment.Dec 01, 2022

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Pubmed Data : Chem Biol Interact. 2022 Dec 2 ;370:110295. Epub 2022 Dec 2. PMID: 36470525

Article Published Date : Dec 01, 2022

Study Type : In Vitro Study

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Substances : Honokiol

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, NF-kappaB Inhibitor

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Pubmed Data : Phytother Res. 2022 Jun ;36(6):2416-2433. Epub 2022 May 18. PMID: 35583746

Article Published Date : May 31, 2022

Study Type : Review

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Substances : Curcumin, Quercetin, Resveratrol

Diseases : Endometriosis

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Antioxidants, Antiproliferative

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Improved anticancer activity of betulinic acid on breast cancer through a grafted copolymer-based micelles system.Nov 30, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Deliv. 2021 Dec ;28(1):1962-1971. PMID: 34565273

Article Published Date : Nov 30, 2021

Study Type : In Vitro Study

Additional Links

Substances : Betulinic acid

Diseases : Breast Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Hypoxia-inducible factor-1 (HIF-1) inhibitor

Additional Keywords : Hypoxia-Inducible Factor 1

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View the Evidence: 474 Abstracts with Angiogenesis Inhibitors Research

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A meta-analysis of ginsenoside Rg3 combined with chemotherapy for digestive system cancer in China.Dec 31, 2018

The efficacy of ginsenoside Rg3 combined with first-line chemotherapy in the treatment of advanced non-small cell lung cancer. Dec 31, 2019

Delta9-tetrahydrocannabinol administration led to the inhibition of the VEGF Pathway in Two Patients with Glioblastoma Multiforme.Aug 14, 2004

Effect of diosmin administration in patients with chronic venous disorders on selected factors affecting angiogenesis.Sep 11, 2019

Vitamin C therapy can down-regulate angiogenesis and inflammation promoting cytokines in some cancer patients.Dec 31, 2015

Makgeolli reduced the tumor size and volume in gastric adenocarcinoma tumor xenografts.Aug 31, 2015

Melatonin has anti-angiogenic effects at different steps of the angiogenic process in SH-SY5Y neuroblastoma cells.Feb 13, 2017

VEGF is a key molecular target for specific polyphenols found in tea, apples and cocoa which potently inhibit VEGF signalling and angiogenesis at physiological concentrations.Feb 28, 2015

Z. multiflora could be introduced as a significant angiogenesis inhibitor for angiogenesis-dependent diseasesMar 31, 2017

Acacetin inhibits in vitro and in vivo angiogenesis and downregulates Stat signaling and VEGF expression.Sep 30, 2013

Alpha-mangostin alleviated HIF-1α-mediated angiogenesis in rats with adjuvant-induced arthritis.Dec 31, 2020

Chrysin-induced regression of angiogenesis in models of melanoma.Jun 05, 2023

Icariin alleviates oxygen-induced retinopathy by targeting microglia hexokinase 2.May 27, 2024

Limonin inhibits angiogenesis and metastasis of human breast cancer cells.Oct 31, 2020

Sesamin inhibits hypoxia-stimulated angiogenesis.Aug 29, 2022

β-sitosterol inhibits rheumatoid synovial angiogenesis.Dec 31, 2020

Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription.Dec 31, 2019

A Huaier polysaccharide restrains hepatocellular carcinoma growth and metastasis.Mar 31, 2015

A novel GP73-regulated oncolytic adenovirus may virtually represent an attractive therapeutic agent for targeting liver CSCs.May 16, 2016

A steroidal derivative from Trigonella foenum graecum L. that induces apoptosis in vitro and in vivo.Dec 31, 2018

Activation of cannabinoid receptors could be a new therapeutic approach for the treatment of skin tumors.Dec 31, 2002

Allyl isothiocyanate ameliorates angiogenesis and inflammation in dextran sulfate sodium-induced acute colitis.Dec 31, 2013

Amygdalin inhibits angiogenesis in the cultured endothelial cells of diabetic rats.Mar 31, 2012

An extract of Thuja orientalis L. inhibited angiogenesis in zebra fish and suppressed the growth of human lung cancer cells.Sep 30, 2018

Anti-angiogenic effects of mangiferin and mechanism of action in metastatic melanoma.Oct 21, 2019

Antitumor activity of ginsenoside Rg3 in melanoma through downregulation of the ERK and Akt pathways.May 31, 2019

Anti‑angiogenic effect of mountain ginseng in vitro and in vivo.Jul 31, 2021

Astaxanthin inhibits the hallmarks of cancer.Jun 27, 2019

Astaxanthin that functions as a potent inhibitor of tumour development and progression.Dec 31, 2013

Baicalein alleviates osteoarthritis by protecting subchondral bone, inhibiting angiogenesis and synovial proliferation.May 02, 2021

Baicalein might be an alternative treatment against refractory chronic inflammation.Nov 25, 2016

Bee venom and its major constituent melittin might represent a potential therapeutic strategy for increasing the radiation response of solid tumors.Dec 31, 2019

Berberine inhibited angiogenesis in glioblastoma xenografts.Nov 30, 2018

Berberine prevents non-alcoholic steatohepatitis-derived hepatocellular carcinoma.Dec 31, 2018

Betanin significantly inhibits lung tumorigenesis in A/J mice and induces apoptosis in lung cancer cells. Aug 31, 2013

Both curcumin and carvacrol showed a great efficacy against hepatocellular carcinoma.Dec 31, 2014

Breast cancer amelioration by Butea monosperma in-vitro and in-vivo.May 09, 2018

Cannabinoids inhibit the growth of gliomas in vivo by targeting both tumor cells and vascular endothelial cells.Feb 28, 2003

Cannabinoids inhibit the growth of melanoma cells but not of normal melanocytes.Nov 30, 2006

Celastrol inhibits angiogenesis and the biological processes of MDA-MB-231 cells.Apr 24, 2024

Combinational treatment effect of tetrahydrocurcumin and celecoxib on cervical cancer cell-induced tumor growth and tumor angiogenesis.Jun 30, 2016

Crocetin and crocin are potential natural biomedicines for the management of diseases associated with abnormal blood vessel growth.Dec 31, 2020

Cucurbitacin B inhibited breast cancer metastasis and angiogenesis.May 18, 2016

Curcumin could be used as an adjuvant agent to chemotherapy in treatment of triple negative breast cancer.Dec 31, 2014

Curcumin-C3complex®/Bioperine® treatment strongly reduces in vitro tumorigenic properties of mesothelioma cells.Aug 15, 2019

Deguelin inhibits human hepatocellular carcinoma by antiangiogenesis and apoptosis.Jun 30, 2008

Dietary oleuropein inhibits tumor angiogenesis and lymphangiogenesis in the B16F10 melanoma allograft model.Mar 30, 2017

Effect of gold nanoparticles treatment on the testosterone-induced benign prostatic hyperplasia in rats.Dec 31, 2018

EGCG can be developed into a potential agent for the prevention and treatment of smoking‑associated NSCLC.May 31, 2015

Electroacupuncture had beneficial effects on chronic obstructive pulmonary disease.Feb 24, 2022

Ellagic acid exerted protective effects against carbon tetrachloride-induced cirrhosis through the inhibition of ROS formation and angiogenesis.Sep 30, 2017

Emodin suppresses angiogenesis and metastasis in anaplastic thyroid cancer.Nov 30, 2018

Fisetin induces the upregulation of AKAP12 mRNA and anti-angiogenesis in a patient-derived organoid xenograft model.Oct 02, 2023

Formononetin, a novel FGFR2 inhibitor, potently inhibits angiogenesis and tumor growth in preclinical models.Dec 28, 2015

Fucoidan from Laminaria japonica exerts antitumor effects on angiogenesis and micrometastasis in triple-negative breast cancer cells.Jan 27, 2020

Fucoidan was able to interfere with angiogenesis of multiple myeloma cells both in vitro and in vivo.Sep 30, 2016

Galangin inhibits epithelial-mesenchymal transition and angiogenesis by downregulating CD44 in glioma.Dec 31, 2018

Geraniol is an attractive candidate for the anti-angiogenic treatment of tumors.Dec 31, 2014

Ginsenoside Rg1 shows significant anticancer properties against breast cancer in experimental models.Dec 31, 2019

Ginsenoside Rg3 prolongs survival of the orthotopic hepatocellular carcinoma model.Dec 31, 2018

Ginsenoside Rg3 significantly inhibited growth and angiogenesis of ovarian cancer when used alone or combined with cyclophosphamide.Apr 04, 2007

Ginsenoside Rg3 targets cancer stem cells and tumor angiogenesis to inhibit colorectal cancer progression in vivo.Dec 31, 2017

Glabridin inhibits migration, invasion, and angiogenesis of human non-small cell lung cancer A549 cells.Nov 30, 2011

Gold nanoparticles carrying quercetin inhibited EMT, angiogenesis and metastasis of the breast cancer cells.Nov 30, 2016

Hesperidin suppressed metastasis, angiogenesis and tumour growth in Balb/c mice model of breast cancer.Aug 31, 2023

Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet.Dec 31, 2018

Identification of phenolics from miracle berry leaf extract and its antiangiogenesis and anticancer activities.Dec 31, 2021

In vitro and in vivo antitumor activity of Yerba Mate extract in colon cancer models.Jun 30, 2020

In vivo attenuation of angiogenesis in hepatocellular carcinoma by Nigella sativa.Feb 22, 2018

Indole-3-carbinol enhances the sensitivity of murine breast adenocarcinoma cells to doxorubicin.Jun 24, 2018

Inhalant cannabidiol impedes tumor growth through decreased tumor stemness.Apr 30, 2023

Inhibition of angiogenesis and inflammation by an extract of red clover.Nov 30, 2009

Angiogenesis Inhibitors

View the Evidence:
474 Abstracts with Angiogenesis Inhibitors Research